MOSAIC - cohort of hospitalised H1N1 patients
Lead Research Organisation:
Imperial College London
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
We have assembled a team of 42 investigators from England and Scotland, bringing their combined expertise to the intensive study of a group of hospitalised patients with influenza. The integration and coordination of all the studies is a logistic challenge, and case ascertainment, definition and sample collection underpins the collaborative network. On this base, some of the UKs best clinical and basic research groups will conduct an integrated|study of influenza virology, host RNA transcriptome and of cellular and humoral immune responses to influenza viral infection. The same patients will also be tested for levels of soluble mediators (cytokines and chemokines) in various body fluids, so allowing the crosscorrelation of the clinical features, virology and RNA transcription profiles on a population|basis. All of this will be linked to the study of the host genome and the bacterial and viral|microbiota present in the respiratory tract as disease evolves, using 16s RNA methods to characterise bacterial populations without the need for culture. The collaborative study of a single set of hospitalised individuals will lead to a wealth of information and the cross correlations between different research outputs will provide|unprecedented opportunities for understanding the pathogenesis of influenza.Research Framework, the Health Protection Agency, London School of Hygiene and Tropical Medicine and the Sanger Institute.|
Organisations
- Imperial College London, United Kingdom (Lead Research Organisation)
- Public Health England (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Public Health England, Salisbury (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- NHS Greater Glasgow and Clyde (NHSGGC) (Collaboration)
- European Scientific Working group on Influenza (ESWI) (Collaboration)
- Royal Liverpool University NHS Hospitals, United Kingdom (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- The Global Health Network (Collaboration)
- Liverpool School of Tropical Medicine (Collaboration)
- University of Nottingham (Collaboration)
Publications
Barclay W
(2018)
The 1918 Influenza Pandemic: one hundred years of progress, but where now?
in The Lancet. Respiratory medicine
Butler CC
(2020)
Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial.
in Lancet (London, England)
Chiu C
(2013)
Cross-reactive humoral responses to influenza and their implications for a universal vaccine.
in Annals of the New York Academy of Sciences
Chiu C
(2015)
Antiviral B cell and T cell immunity in the lungs.
in Nature immunology
Dunning J
(2020)
Seasonal and pandemic influenza: 100 years of progress, still much to learn.
in Mucosal immunology
Dunning J
(2018)
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.
in Nature immunology
Dunning J
(2011)
Doctors accepting flu vaccination is the sensible and responsible choice.
in BMJ (Clinical research ed.)
Dunning J
(2019)
Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.
in Nature immunology
Dunning J
(2010)
Impact of the 2009 influenza pandemic.
in Thorax
| Title | How to Catch Flu |
| Description | We commissioned the famous illustrator Steven Appleby and animator Pete Bishop to create a video 'How to Catch Flu' and an interactive stand exemplifying MOSAIC's research. A novel flu dominoes game was created with a range of 100 hand-drawn characters, including the 'at-risk' groups (elderly, obsess, pregnant, asthmatic etc.); some dominoes were 'vaccinated' (unable to topple). A table-top city scape was designed which allowed members of the public to create outbreaks. Participants were also invited to sketch their own virus. https://www.flickr.com/photos/123813534@N03/sets/ 'How to Catch Flu' was developed with a wide age range in mind. It conveys clear but subtle messages about how to prevent flu and what to do if you catch it. It has been shown to focus groups of children, to planners from Health Protection England, to groups of paediatricians and others and has been acclaimed as a highly engaging and memorable output from the grant. https://www.youtube.com/watch?v=nTtCBzOV0BY http://www.mediafire.com/download/39pocth3p6i0jcv/Happy720p.mp4.zip See also: http://www1.imperial.ac.uk/mosaic/ https://twitter.com/MOSAICStudy |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2014 |
| Impact | Video has since been uploaded onto National STEM database as a resource for teachers |
| URL | http://www1.imperial.ac.uk/mosaic/howtocatchflu/ |
| Description | BSI President |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | The British Society for Immunology (BSI) is the largest immunology society in Europe and the second largest in the world. We are a learned society representing the interests of members working in academia, clinical medicine, and industry. Our main objective is to promote and support excellence in research, scholarship and clinical practice in immunology for the benefit of human and animal health. |
| URL | https://immunology.org/resources-careers--education/policy-and-public-affairs/--bsi-resources-policy... |
| Description | European Scientific Working Group on Influenza (ESWI) |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | I am Vice-President of ESWI, which works to promote understanding of influenza as a disease, and to increas the use of vaccines and antiviral drugs in order to lessen the impact of flu in Europe. |
| Description | ISARIC |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Large consortium of consortia, co-ordinating pandemic research internationally. |
| Description | Invitation to participate in International Influenza Networks Meeting |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Joint Committee on Vaccination and Immunisation (influenza/RSV) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | PREPARE |
| Geographic Reach | Asia |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Scientific Advisory Group in Emergencies |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Part of small advisory group, chaired by the Government Chief Scientist, advising the Cabinet on pandemic responses. This committee took a central role in steering the pandemic response. |
| Description | Biomedical Research |
| Amount | £400,000 (GBP) |
| Organisation | Imperial College Healthcare NHS Trust |
| Sector | Hospitals |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 03/2015 |
| Description | Biomedical Research Centre (BRC) |
| Amount | £568,695 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 03/2016 |
| Description | FP7 |
| Amount | € 1,352,200 (EUR) |
| Funding ID | 602525 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2014 |
| End | 12/2018 |
| Description | MRC EMINENT grant |
| Amount | £8,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 01/2021 |
| Description | NIHR Imperial Biomedical Research Centre |
| Amount | £90,008,747 (GBP) |
| Organisation | Barts Health NHS Trust |
| Department | NIHR Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2022 |
| Description | PREPARE |
| Amount | € 1,000,000 (EUR) |
| Funding ID | 60525 |
| Organisation | University of Antwerp |
| Sector | Academic/University |
| Country | Belgium |
| Start | 02/2014 |
| End | 01/2019 |
| Description | Respiratory Infection Health Protection Unit (HPRU) |
| Amount | £3,427,262 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 03/2019 |
| Description | Senior Investigator |
| Amount | £75,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 03/2019 |
| Description | Wellcome Trust Translational Fund |
| Amount | £2,550,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2018 |
| Title | Clinical information |
| Description | We have an extensive database of clinical information from 256 cases of influenza-like illness, mostly from pH1N1 influenza but also from control groups. |
| Type Of Material | Biological samples |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | Extensive material that can be cross-correlated with laboratory outputs |
| Title | Dataset |
| Description | The team within MOSAIC has produced a database linking all the outputs from MOSAIC in searchable form. This unique resource contains all data collected or generated in MOSAIC. Additionally, it contains detailed documentation about what is located within the databases, methods for generating the information and other methodological details. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | No impacts yet |
| Title | Diverse timed samples collected from cases of influenza-like illness |
| Description | We have 8000 samples archived. Processing almost complete |
| Type Of Material | Biological samples |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | Laboratory analysis across the consortium is approaching conclusion having encompassed multiple disciplines. These inlcude host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses. |
| Title | FLU-CIN |
| Description | The Influenza Clinical Information Network (FLU-CIN) surveillance network was established by the Department of Health in England on 11 May 2009. We have used the FLUCIN data collection form as the principal method of collecting clinical data from the study recruits |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | Using this tool has enabled us to build a rich clinical dataset to complement the laboratory gerenated data from the biological samples that the study recruits provided. We have implemented rigourous validation and quality control procedures to ensure that this information is correct and in a format that will be flexible and easy to use in analysis |
| Title | Dataset |
| Description | The data team within MOSAIC has produced a database linking all the outputs from MOSAIC in searchable form. This unique resource contains all data collected or generated in MOSAIC. Additionally, it contains detailed documentation about what is located within the databases, methods for generating the information and other methodological details. These data were centrally managed in our core data team, headed by a researcher with over 10 years' experience collecting, managing and analysing clinical information. All data were validated and where appropriate double entered/double checked for accuracy. Documentation and clinical decisions regarding how patients should be classified were organised by the data team through documented expert meetings and assessment of the data. These data are shared across the MOSAIC investigator teams and with other researchers through a data request scheme. Once checked and mined by MOSAIC investigators, these data will be available to any researcher on request. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | N/A |
| Description | ESWI |
| Organisation | European Scientific Working group on Influenza (ESWI) |
| Country | Belgium |
| Sector | Charity/Non Profit |
| PI Contribution | Openshaw served as ESWI's vice-president for 5 years, stepping down in September 2014. |
| Collaborator Contribution | ESWI ()European Scientific Working Group on Influenza) was established in 1993. Along with the main stakeholders ESWI aims to educe the burden of influenza in Europe. The Members are twelve scientific experts, health care professionals, public health officials, at-risk patients and the elderly. ESWI collaborates with the World Health Organisation to enhance vaccine coverage of people at high risk of getting severe complications when infected with influenza. |
| Impact | Openshaw acted as vice president |
| Start Year | 2009 |
| Description | HPRU |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Health Protection Research Unit on Respiratory Viruses, Openshaw is lead on 'RSV theme' and a member of the management committee. |
| Collaborator Contribution | Building on research done by MOSAIC |
| Impact | Continuing research already undertaken by MOSAIC |
| Start Year | 2013 |
| Description | HPRU |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Health Protection Research Unit on Respiratory Viruses, Openshaw is lead on 'RSV theme' and a member of the management committee. |
| Collaborator Contribution | Building on research done by MOSAIC |
| Impact | Continuing research already undertaken by MOSAIC |
| Start Year | 2013 |
| Description | ISARIC |
| Organisation | The Global Health Network |
| Department | International Severe Acute Respiratory Infection Consortium (ISARIC) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | MOSAIC contributed to the initial set up of the project with core document development and refinement, as well as suggesting ways to measure nCoV cytokines. Openshaw, Dunning and Semple are ISARIC Council members |
| Collaborator Contribution | ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) is a global initiative aiming to ensure that clinical researchers have the open access protocols and data-sharing processes needed to facilitate a rapid response to emerging diseases that may turn into epidemics or pandemics https://isaric.tghn.org |
| Impact | MOSAIC assisted in initial set up of of ISARIC and MOSAIC members are active in Council |
| Start Year | 2012 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | Health Protection Agency |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | Liverpool School of Tropical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Department | Gartnaval West of Scotland Specialist Virology Centre |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | Royal Liverpool University Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | University of Nottingham |
| Department | School of Community Health Sciences Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | MOSAIC (Mechanisms of Severe Acute Influenza Consortium |
| Organisation | University of Oxford |
| Department | Weatherall Institute of Molecular Medicine (WIMM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections. |
| Collaborator Contribution | MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input. |
| Impact | The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis. |
| Start Year | 2009 |
| Description | PREPARE |
| Organisation | Public Health England |
| Department | Centre for Emergency Preparedness and Response Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Openshaw is active in several of the work packages |
| Collaborator Contribution | PREPARE (Platform foR European Preparedness Against (RE-) emerging Epidemics) was funded by the EU commission in 2013. It is a consortium of 21 organisations that aims to identify and implement solutions to roadblocks against rapid implementation of clinical research during severe outbreaks http://www.prepare-europe.eu |
| Impact | Openshaw is a co-applicant and receives funding to do work that builds on the findings of MOSAIC |
| Start Year | 2014 |
| Description | PREPARE |
| Organisation | Public Health England |
| Department | Centre for Emergency Preparedness and Response Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Openshaw is active in several of the work packages |
| Collaborator Contribution | PREPARE (Platform foR European Preparedness Against (RE-) emegering Epidemics) was funded by the EU commission in 2013. It is a consortium of 21 organisations that aims to identify and implement solutions to roadblocks against rapid implementation of clinical research during severe outbreakshttp://www.prepare-europe.eu |
| Impact | Openshaw is a co-applicant and receives funding to do work that builds on the findings of MOSAIC |
| Start Year | 2014 |
| Title | Synthetic adsorbative matrix (SAM) strips |
| Description | The adsorbative strips are placed in the nose or lung to obtain fluid samples for prognostic and diagnostic use. These were developed by Dr Hansel (a MOSAIC investigator) and have been tested experimentally in asthma and hay fever, but not on the scale used in MOSAIC. |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2008 |
| Development Status | Under active development/distribution |
| Impact | The novel sampling method is expected to have clinical impact once the experimental phase is completed. |
| Description | BBC Newsnight feature |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Part of a BBC Newsnight feature on pH1N1 influenza, the impact it was having during the winter of 2010/11 and research efforts to understand pathogenesis. N/A |
| Year(s) Of Engagement Activity | 2011 |
| Description | British Society of Immunology response to annual vaccination statistics for England |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Peter Openshaw quoted in BBC News Online, Daily Telegraph and Huffington Post - 22nd September 2016 |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cafe' Scientifique |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The presentation was given in relation to the H1N1 Influenza Pandemic Students were interested in the discussion |
| Year(s) Of Engagement Activity | 2011 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Openshaw also delivered a talk on 'Flu A Pandemic In Waiting?' at the Festival N/A |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www1.imperial.ac.uk/mosaic/events/cheltenham2014/ |
| Description | Croonian lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Croonian Lecture RCP Croonian lecture in 2013 |
| Year(s) Of Engagement Activity | 2013 |
| Description | How to Catch Flu film |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We commissioned the famous illustrator Steven Appleby and animator Pete Bishop to create a video 'How to Catch Flu' and an interactive stand exemplifying MOSAIC's research. A novel flu dominoes game was created with a range of 100 hand-drawn cahracters, including 'at risk' groups (elderly, obese, pregnant, asthmatic, etc); some dominoes were 'vaccinated' (unable to topple). A table-top cityscape was designed which allowed members of the public to vreate outbreaks. Participants were also invited to sketch their own virus. http://www.flickr.com/photos/123813534@N03/sets 'How to Catch Flu' was developed with a wide range in mind. It conveys clear but subtle messages about how to rpevent flu and what to do if you catch it. It has been shown to focus groups of children, to planners from Health Protection England, to groups of paediatricians and others and has been acclaimed as a highly engaging and memorable output. It has been added to the National STEM Centre database for teaching tools |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www1.imperial.ac.uk/mosaic/howtocatchflu/ |
| Description | Imperial Festival of Science |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Festival attended by over 10,000 people and the MOSAIC stall was one of the most popular with visitors. Openshaw also gave a talk 'Spanish Flu to Swine Flu' which was open to the public N/A |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/eventssummary/event_30-4-2014-10-44-37 |
| Description | Interview on BBC Radio 2 - immune system |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Peter Openshaw interviewed about how to keep your immune system healthy. You can listen to the interview - 4th January 2016 at 16 min 40 sec into this recording. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Live Presentation in Brussels |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Last year I gave a 30 minute stage performance in a theatre in Brussels (the Albert Hall) to a public audience, recounting anecdotes and describing my sources of scientific inspiration. N/A |
| Year(s) Of Engagement Activity | 2012 |
| Description | Medical marvels: how vaccines protect, and what can go wrong |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 120 staff, pupils and parents attened this talk, which aimed to entertain and inform about the science, policy and pitfalls behind vaccines. Several enquiries about internships and university applications. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Natural History Museum Science Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | MOSAIC stand at Natural History Museum Science Uncovered event N/A |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www1.imperial.ac.uk/mosaic/events/scienceuncovered/ |
| Description | Openshaw lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stimulate conversation as part of RSV talks N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Openshaw plenary lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | EFIS Lecture Award: "Protective and inflammatory responses in respiratory virus infections." N/A |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.irishimmunology.ie/ISI%20Programme%202014.pdf |
| Description | Openshaw talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Openshaw gave keynote lecture N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Openshaw talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The BSI Summer School is a unique learning experience aimed primarily at individuals who are new to the field of immunology or who want to enhance their immunological knowledge. To be held within the historic city of Edinburgh, the 2014 BSI summer school will feature presentations from leading immunologists who will teach the fundamental principles of immunology in the context of cutting edge research. • Immunology taught by world-leading Immunologists • Fundamental and current topics in Immunology • Interactive tutorials and workshops • Immunology 'Dragon's Den' • Fantastic Social activities. N/A |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://immunology.org/events--meetings/summer-schoo-2014/--bsi-events--meeting-edinburgh-summer-sch... |
| Description | Openshaw talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Openshaw Chaired sessions at conference as well as giving talks on RSV N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Openshaw talk (open to public) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on influenza outbreaks, open to members of the public Raise public awareness |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.friendsofimperial.org.uk/FOIC-Index.php?pg=FullEvent&from=Past-Events&yr=13&ev=130 |
| Description | Openshaw talks |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Openshaw Chaired sessions and gave keynote speeches during conference N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Panel discussion |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | International Influenza Networks Meeting (Arizona) We would like you to participate in the Panel on "Clinical/Research Networks" on Monday, January 14, 2013. During the panel discussion, you would present on the Mechanisms of Severe Acute Influenza Consortium (MOSAIC) - their goals, unique attributes, information gathered, and current strengths/gaps. A preliminary meeting agenda is attached for your review. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Press conference, Wellcome Trust |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Excellent turnout of specialist science journalists and those looking for a flu story. About 30 attenees Several national newspapers published stories mentioning ongoing studies, contributing to the awareness for the need for seasonal flu vaccines |
| Year(s) Of Engagement Activity | 2010,2011 |
| Description | Press release (Sanger Isntitute) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | News release outlined major findings from a consortium publication. The work described identified a human gene (IFITM3) that influences how we respond to influenza infection. People who carry a particular variant are significantly more likely to be hospitalised when they fall ill with influenza than those who carry other variants Significant media interest followed this release including and interview on BBC radio 4's today programme |
| Year(s) Of Engagement Activity | 2012 |
| Description | Radio Interview (Today Programme, BBC R4) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Following a press release from the Sanger institute that outlined the findings from a consortium publication on a genetic correlate of influenza severity, the Today programme ran a report on the subject which featured interviews with the head of the consortium and the PI from the Sanger. The report also showcased the scope and originality of the MOSAIC consortium and it's potential impact on the study and treatment of future pandemics. This activity raised the profile of MOSAIC and it's output to a non-scientific audience. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Rule that patients must finish antibiotics course is wrong, study says - Interview for the Guardian |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Comments in relation to the article on antibiotics |
| Year(s) Of Engagement Activity | 2017 |
| Description | Science Inspired Tales |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Video edited and put online Asked if I would do another on a different topic |
| Year(s) Of Engagement Activity | 2012 |
| Description | Society for General Microbiology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public outreach for MOSAIC study N/A |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www1.imperial.ac.uk/mosaic/events/sgm2014/ |
| Description | TV interview |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | TV appearance on "Daybreak" Asked to speak on flu vaccines |
| Year(s) Of Engagement Activity | 2013 |
| Description | Talk about research on MOSAIC to the Imperial College Academic Health Science Centre |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | To speak at the AHSC seminar series about the research into influenza and the MOSAIC project. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Understanding and treating the flu virus AHSC Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Peter Openshaw will discuss the MOSAIC project which collected data from over 250 flu patients to inform new treatments |
| Year(s) Of Engagement Activity | 2016 |
| Description | Wellcome Trust Masterclass |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We hosted a publically accessible immunology 'Masterclass' last year at the Wellcome Trust at which Jonathan Yewdell inspired an audience that included many students from London schools. N/A |
| Year(s) Of Engagement Activity | 2011 |
| Description | Why some people catch every cold going and others none: Genetics, stress and even childhood can all affect immune system |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Peter Openshaw quoted in Daily Mail article - 18th January 2016 |
| Year(s) Of Engagement Activity | 2016 |