Imaging perfusion deficits and thrombolysis safety and efficacy in acute ischaemic stroke. The Third International

Lead Research Organisation: University of Edinburgh

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Scientific Abstract|Design: Main trial: IST-3 is an international, prospective, randomised, open, blinded end-point (PROBE) controlled trial of i.v. rt-PA within 6 hours of onset of acute ischaemic stroke (www.ist3.com). Plain CT brain scanning is the prime imaging modality for the main trial. Perfusion study: In centres where MR or CT perfusion are part of routine acute stroke care, the data from patients who have MR diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI), or CT with perfusion (CTP) imaging at baseline before entry in IST3 will be collected and analysed centrally in addition to their non-contrast CT or MR DWI. We will measure infarct growth between baseline and 24-48 hour follow-up imaging, among patients with versus without DWI/PWI or CTP mismatch, with rt-PA versus control in patients with perfusion data. |Setting: Main trial: Hospitals in the UK, Europe, North America, Australia, with stroke units where evidence-based care pathways for stroke (including for administration of rt-PA) are in use. IST-3 currently has 97 active centres (+ 86 who may join) in 12 countries worldwide. Perfusion study: Of these, 12 centres are using MR for baseline assessment instead of CT, eight have already sent 12 MR PWI data and five have sent 23 CTP scans in acute stroke. |Project timetables including recruitment rate: IST-3 Main trial: stops recruitment in late 2011. Recruitment is on target. All regulatory approvals (including Human Research Ethics Committee approvals in 97 centres in 12 countries), randomisation, central data collection are in place. The IST-3-perfusion study: can start immediately. The centres that are already using perfusion imaging are some of the most active in IST-3. |Therefore we estimate that over the next 3 years, in 15 active centres, recruiting between four and eight patients per year each, the perfusion study will include between 100 and 300 patients. Based on scan data received so far, we anticipate a rate of two CTP to one MR PWI although a higher rate of four CTP to one MR DWI is possible. Both will provide valuable data. |Ultimately, we will contribute the perfusion data to an international collaboration performing an individual patient data metaanalysis of perfusion imaging.

Publications

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Arba F (2017) Cerebral White Matter Hypoperfusion Increases with Small-Vessel Disease Burden. Data From the Third International Stroke Trial. in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

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Dickie DA (2018) Blood pressure variability and leukoaraiosis in acute ischemic stroke. in International journal of stroke : official journal of the International Stroke Society

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El-Tawil S (2017) Penumbra and re-canalization acute computed tomography in ischemic stroke evaluation: PRACTISE study protocol. in International journal of stroke : official journal of the International Stroke Society

 
Description STAIR VIII (Stroke Treatment Academic Industry Roundtable)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2)
Amount £1,000,000 (GBP)
Funding ID TSABHF2015/01 
Organisation Stroke Association 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2016 
End 01/2021
 
Description Cohen Charitable Trust
Amount £10,000 (GBP)
Organisation The Cohen Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Doctor of Medicine
Amount £815 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 10/2012 
End 09/2015
 
Description Enhanced Control of Hypertension and Thrombolysis Stroke Study (STAY ENCHANTED)
Amount £209,999 (GBP)
Funding ID TSA2015/01 
Organisation Stroke Association 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2018
 
Description NIHR EME
Amount £1,243,488 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2013 
End 06/2016
 
Description PhD studentship (MRC/CCBS, SINAPSE, Anthony Watson Bequest)
Amount £17,078 (GBP)
Organisation Government of Scotland 
Department Scottish Funding Council
Sector Public
Country United Kingdom
Start  
 
Description PhD studentship (MRC/CCBS, SINAPSE, Anthony Watson Bequest)
Amount £17,078 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start  
 
Description Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial
Amount £1,449,092 (GBP)
Funding ID CS/14/4/30972 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 04/2018
 
Description Real-world Independent Testing of eASPECTS Software (RITeS)
Amount £83,716 (GBP)
Funding ID STA CR 2017/01 
Organisation Stoke Association 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 07/2019
 
Description TSA Clinical Trial Project Grant: "Real-world Independent Testing of eASPECTS Software (RITeS)"
Amount £51,716 (GBP)
Funding ID TSA CR 2017/01 
Organisation Stroke Association 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 12/2018
 
Description TSA Edith Murphy Foundation Senior Clinical Lectureship for Medical Professionals: "Realising the full potential of routinely-available brain imaging to improve treatment of patients with acute stroke."
Amount £234,841 (GBP)
Funding ID SAL-SMP18/1000 
Organisation Stroke Association 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 04/2023
 
Title RapidBrain 
Description Brain imaging researchers execute complex multistep workflows in their computational analysis. Those workflows often include applications that have very different user interfaces and sometimes use different data formats. A good example is the brain perfusion quantification workflow used at the BRIC (Brain Research Imaging Centre) in Edinburgh. Rapid provides an easy method for creating portlets for computational jobs, and at the same it is extensible. We have exploited this extensibility with additions that stretch the functionality beyond the original limits. These changes can be used by other projects to create their own portals, but it should be noted that the development of such portals involve a greater effort than the required in the regular use of Rapid for creating portlets. In our case it has been used to provide a user-friendly interface for perfusion analysis that covers from volume. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact None as yet. 
URL http://www.neuroimage.co.uk/SIRS/
 
Title Systematic Image Review System 2 (SIRS 2) web-based image reading tool 
Description The Systematic Image Review System (SIRS) Tool is suitable for performing: a) large observer reliability studies of image interpretation b) independent image review for trials or observational studies c) continuing professional development (CPD) and eLearning. Its functionality derives from the need to answer key research or educational issues and to meet the usability criteria defined by professional users of imaging, e.g. radiologists. Although originally designed for radiological images such as CT or MR brain scans, the same technology could be used for the reasons given above for situations where other types of images are used, eg histology, photographs of skin rashes or faces. http://www.neuroimage.co.uk/sirsinfo/ 
Type Of Material Biological samples 
Year Produced 2008 
Provided To Others? Yes  
Impact Used to facilitate image reading for multiple studies. 
URL http://www.neuroimage.co.uk/sirsinfo/
 
Description ENCHANTED Trial Investigation 
Organisation University of Leicester
Department Department of Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise and analysis tools
Collaborator Contribution Trial organisation
Impact No outcomes or outputs yet because the collaboration only started in 2016.
Start Year 2016
 
Description ENCHANTED Trial Investigation 
Organisation University of Sydney
Country Australia 
Sector Academic/University 
PI Contribution Expertise and analysis tools
Collaborator Contribution Trial organisation
Impact No outcomes or outputs yet because the collaboration only started in 2016.
Start Year 2016
 
Description Francesco Arba, Florence 
Organisation University of Florence
Country Italy 
Sector Academic/University 
PI Contribution Access to data, training, supervision of analysis
Collaborator Contribution Assessed scans and analysis.
Impact Paper submitted to Stroke. Abstract submitted to ESO conference. Submitting PhD thesis including the work.
Start Year 2015
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation John Hunter Hospital
Department Neurology Clinic
Country Australia 
Sector Hospitals 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation Medical University of Gdansk
Country Poland 
Sector Academic/University 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation Medical University of Warsaw
Department Institute of Psychiatry and Neurology
Country Poland 
Sector Academic/University 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation Medical University of Warsaw
Department Institute of Psychiatry and Neurology
Country Poland 
Sector Academic/University 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation The Children's Hospital at Westmead
Country Australia 
Sector Hospitals 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation University Hospital Carl Gustav Carus Dresden
Department Department of Neuroradiology
Country Germany 
Sector Academic/University 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description Investigator Meeting World Stroke Conference, Brasilia 
Organisation University of Edinburgh
Department School of Molecular and Clinical Medicine Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Collaborator Contribution Participating in multi-centre scan reading project, processing image data, and testing new analysis methods.
Impact Publications as listed
Start Year 2011
 
Description PRACTISE Trial Collaboration 
Organisation King's College London
Department Stroke Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Secured funding for trial of CT angiography and perfusion in routine practice.
Collaborator Contribution Design of trial, secured funding, study set up. Please note that amount of contribution currently not known.
Impact N/A
Start Year 2013
 
Description PRACTISE Trial Collaboration 
Organisation University of Glasgow
Department Institute of Neuroscience and Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Secured funding for trial of CT angiography and perfusion in routine practice.
Collaborator Contribution Design of trial, secured funding, study set up. Please note that amount of contribution currently not known.
Impact N/A
Start Year 2013
 
Description STIR Collaboration on Standards for Imaging 
Organisation National Institutes of Health (NIH)
Department National Institute of Neurological Disorders and Stroke (NINDS)
Country United States 
Sector Public 
PI Contribution Chaired workgroup on revascularisation imaging; drafted text; collected responses; prepared final papers for publication (x2)
Collaborator Contribution Contributed data or discussed analyses
Impact 2x STIR papers
Start Year 2012
 
Description STIR Collaboration on Standards for Imaging 
Organisation University of Glasgow
Department Stroke Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Chaired workgroup on revascularisation imaging; drafted text; collected responses; prepared final papers for publication (x2)
Collaborator Contribution Contributed data or discussed analyses
Impact 2x STIR papers
Start Year 2012
 
Description Stroke Thrombolysis Trialists Collaboration 
Organisation University of Calgary
Department The Calgary Stroke Program
Country Canada 
Sector Academic/University 
PI Contribution data
Collaborator Contribution Individual patient data and analysis
Impact Three publications: Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Tilley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, del Zoppo GJ, Baigent C, Sandercock P, Hacke W, for the Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014;384: 1929-1935. Whiteley WN, Emberson J, Lees KR, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Olivot JM, Parsons M, Toni D, Toyoda K, Wahlgren N, Wardlaw J, del Zoppo GJ, Sandercock P, Hacke W, Baigent C. Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurol 2016;15:925-933. Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, Grotta JC, Kaste M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Murray GD, Sandercock PAG, Toni D, Toyoda K, Wardlaw JM, Whiteley WN, Baigent C, Hacke W, Howard G. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of nine trials. Stroke 2016;47:2373-2379.
Start Year 2013
 
Description Stroke Thrombolysis Trialists Collaboration 
Organisation University of Oxford
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution data
Collaborator Contribution Individual patient data and analysis
Impact Three publications: Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Tilley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, del Zoppo GJ, Baigent C, Sandercock P, Hacke W, for the Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014;384: 1929-1935. Whiteley WN, Emberson J, Lees KR, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Olivot JM, Parsons M, Toni D, Toyoda K, Wahlgren N, Wardlaw J, del Zoppo GJ, Sandercock P, Hacke W, Baigent C. Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurol 2016;15:925-933. Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, Grotta JC, Kaste M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Murray GD, Sandercock PAG, Toni D, Toyoda K, Wardlaw JM, Whiteley WN, Baigent C, Hacke W, Howard G. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of nine trials. Stroke 2016;47:2373-2379.
Start Year 2013
 
Description "Alteplase (recombinant tissue Plasminogen Activator, rt-PA) for the Treatment of Acute Ischemic Stroke", Inclusion of a new individual medicine in the 21st edition of the World Health Organization Model List of Essential Medicines (EML) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Alteplase (recombinant tissue Plasminogen Activator, rt-PA) for the Treatment of Acute Ischemic Stroke", Inclusion of a new individual medicine in the 21st edition of the World Health Organization Model List of Essential Medicines (EML).

Comments from the WHO appraisal Committee are at:
https://www.who.int/selection_medicines/committees/expert/22/applications/alteplase/en/

Supporting document to WHO appraisal committee submitted by WSO:
https://www.who.int/selection_medicines/committees/expert/22/applications/s12.5.2_alteplase.pdf
Year(s) Of Engagement Activity 2018
URL https://apps.who.int/iris/handle/10665/325771
 
Description 11° Congresso Português do AVC, talk by Prof Joanna Wardlaw: "Imaging studies in vascular cognitive impairment" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give a talk at the 11° Congresso Português do AVC (11th Portuguese Stroke Congress) in Porto, Portugal, on 2 February 2016; the talk was "Imaging studies in vascular cognitive impairment".
Year(s) Of Engagement Activity 2017
 
Description 16th Belgian Stroke Council International Symposium - Prof Joanna Wardlaw participated in a deabte on "Should we still perform a perfusion-CT?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact At the 16th Belgian Stroke Council International Symposium - a joint symposium of the Belgian Neurological Society and the Belgian Stroke Council, endorsed by the European Stroke Organisation (ESO) - Prof Joanna Wardlaw was asked to participate in a debate on "Should we still perform a perfusion-CT?". Prof Wardlaw advocated for "no". The symposium took place on 2 December 2017 in Leuvan, Belgium.
Year(s) Of Engagement Activity 2017
 
Description Alzheimer's Research UK Manchester and NorthWest Network Centre Science Day, talk by Prof Joanna Wardlaw: "Vascular disease and neurodegeneration - structural and functional insights from neuroimaging in humans" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give at talk at the Alzheimer's Research UK Manchester and NorthWest Network Centre Science Day on 18 May 2016, in Manchester, UK. The talk was entitled: "Vascular disease and neurodegeneration - structural and functional insights from neuroimaging in humans".
Year(s) Of Engagement Activity 2016
URL http://www.alzheimersresearchuk.org/research-projects/alzheimers-research-uk-manchester-north-west-n...
 
Description American Society of Neuroradiology Annual Meeting, talk by Dr Grant Mair: "CT angiography in acute stroke: a subgroup analysis of the Third International Stroke Trial." 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Grant Mair gave a talk, CT angiography in acute stroke: a subgroup analysis of the Third International Stroke Trial, at the American Society of Neuroradiology Annual Meeting in San Diego, USA in 2013.
Year(s) Of Engagement Activity 2013
 
Description British Institute of Radiology, invited lecture by Dr Grant Mair: "Stroke Imaging: What does the future hold?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Grant Mair was invited to give a lecture at the British Institute of Radiology, London, UK, in June 2016. The title of the lecture was: "Stroke Imaging: What does the future hold?"
Year(s) Of Engagement Activity 2016
 
Description British Society of Neuroradiologists Annual Meeting, talk by Dr Grant Mair: "Response to intravenous rt-PA in ischaemic stroke patients with and without arterial occlusion on CTA: The Third International Stroke Trial (IST-3)" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Grant Mair gave a talk on "Response to intravenous rt-PA in ischaemic stroke patients with and without arterial occlusion on CTA: The Third International Stroke Trial (IST-3)" at the British Society of Neuroradiologists Annual Meeting in Oxford, UK, in October 2013.
Year(s) Of Engagement Activity 2013
 
Description European Stroke Organisation Conference (ESOC), poster presented by Dr Grant Mair: 'Feasibility of using brain attenuation changes on CT to accurately predict time of ischaemic stroke onset' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Grant Mair presented a poster at the European Stroke Organisation Conference (ESOC) in Prague, from 16-18 May 2017: Mair G, Sandercock PAG, Wardlaw JM. Feasibility of using brain attenuation changes on CT to accurately predict time of ischaemic stroke onset. European Stroke Journal 2017; 2(IS):252.
Year(s) Of Engagement Activity 2017
URL http://www.eso-conference.com/2018/useful-links/previous-esoc-conferences#.WldThmsUlHg
 
Description International Centre for Mathematical Sciences Information Geometry Workshop, Dr Grant Mair gave the plenary lecture on: "Medical Imaging of the brain" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Grant Mair gave the plenary lecture at the International Centre for Mathematical Sciences Information Geometry Workshop in Edinburgh, UK, in September 2015. The title of the lecture was: "Medical Imaging of the brain."
Year(s) Of Engagement Activity 2015
 
Description Prof Joanna Wardlaw feature in Health Matters magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A feature in Health Matters magazine, Winter 2018-2019 issue, P 24-25. Wardlaw, JM. "MRI scans of the brain".
Year(s) Of Engagement Activity 2019
 
Description Prof Joanna Wardlaw lecture "Brain Health: a small matter of the blood vessels" in Edinburgh, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Edinburgh Neuroscience Public Christmas Lecture 2018
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw lecture "Neuroimaging in acute ischaemic stroke: history, current and future" in Stockholm, Sweden. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw gave a special lecture on "Neuroimaging in acute ischaemic stroke: history, current and future" at the ESO-Karolinska Stroke Update Conference in Stockholm, Sweden on November 12, 2018.
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw lecture "Where next for stroke research?" in Edinburgh, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 6th Edinburgh Stroke Winter School, 18th-20th February 2019.
Year(s) Of Engagement Activity 2019
 
Description Prof Joanna Wardlaw talk "What makes a good paper and how to prepare it? Suggestions based on my person experience",Beijing, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw talk "What makes a good paper and how to prepare it? Suggestions based on my person experience", at the Tiantan International Stroke Conference 2019, 28 June 2019, Beijing, China
Year(s) Of Engagement Activity 2019
 
Description Prof Joanna Wardlaw talk "Where next for stroke research?" in Edinburgh, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw talk "Where next for stroke research?"at the 6th Edinburgh Stroke Winter School, 19th February 2019, Edinburgh, UK.
Year(s) Of Engagement Activity 2019
 
Description Professor Wardlaw talk titled "Practical brain imaging to identify patients for reperfusion therapies in acute ischaemic stroke", (2019) Tiantan International Stroke Conference, Beijing, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Wardlaw talk titled "Practical brain imaging to identify patients for reperfusion therapies in acute ischaemic stroke", (2019) Tiantan International Stroke Conference, Beijing, China
Year(s) Of Engagement Activity 2019
 
Description Royal College of Physicians 'Women in medicine: a celebration' project 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal College of Physicians (RCP)'s 'Women in medicine: a celebration' project is a free exhibition of specially commissioned photographic portraits to honour contemporary and historical women in medicine. The project showcased a number of today's leading female clinicians and the women from the history of medicine who have inspired them. Prof Joanna Wardlaw is featured in the project alongside someone who inspired her, Marie Sklodowska Curie: https://www.rcplondon.ac.uk/projects/outputs/women-medicine-joanna-wardlaw-and-marie-curie
Year(s) Of Engagement Activity 2017
URL https://www.rcplondon.ac.uk/events/women-medicine-celebration
 
Description Royal College of Radiologists Research Day, talk by Prof Joanna Wardlaw: "A day in the life of an academic radiologist" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give at talk at the Royal College of Radiologists Research Day on 15 November 2016 in London, UK. The talk was entitled, "A day in the life of an academic radiologist".
Year(s) Of Engagement Activity 2016
 
Description SVD Research LinkedIn 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SVD Research LinkedIn social media channel promoting work of the University of Edinburgh SVD Research groups, including publications, awards, press releases, recent vacancies and other associated activities, aiming to build an international network of professionals specialising in the SVD Research and promote the research to funding bodies, policy makers and industry professionals.
Year(s) Of Engagement Activity 2021
URL https://uk.linkedin.com/in/svd-research-5aaa27199
 
Description Scottish Church Theology Society, talk by Prof Joanna Wardlaw: "The challenges of modern biology - the brain" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Joanna Wardlaw was invited to give a talk at The Scottish Church Theology Society on 12 January 2016 in Peebles, UK. The talk was entitled: "The Challenge of Modern Biology - The Brain".
Year(s) Of Engagement Activity 2016
 
Description Scottish Radiological Society Annual General Meeting, talk by Prof Joanna Wardlaw: "The Role of Acute Imaging in Stroke" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give at talk at the Scottish Radiological Society's Annual General Meeting on 11 November 2016 in Dundee, UK. The talk was "The role of acute imaging in stroke".
Year(s) Of Engagement Activity 2016
URL http://www.radiology.co.uk/meetings
 
Description Stroke Association's Keynote Lecture given by Prof Joanna Wardlaw "One small vessel stroke? One giant problem for humankind" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact The Stroke Association's Keynote Lecture is a prestigious event that showcases the latest advancements being made in stroke research. In 2016, the Keynote Lecture was held at Lancaster House.

Professor Wardlaw addressed 'small vessel disease' which is the most common cause of vascular dementia. Although vascular dementia is the second most common form of dementia, for too long there has been insufficient research into this disease.
Year(s) Of Engagement Activity 2016
URL https://www.stroke.org.uk/news/keynote-lecture-2016
 
Description The Row Fogo Centre for Research into Ageing and the Brain website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Being officially recognised as a Research Centre in 2018, The Row Fogo Centre for Research into Ageing and the Brain launched a new website. The website is directed in multiple audiences. Content includes a comprehensive description of the Centre research activity, updates on recent publications, news and organised events. The website contains information for PhD candidates and medical imaging researchers about related programmes and courses, and for visiting staff and students on how to join SVD Research Groups. The website gives a breadth of ways to fundraise and donate to support SVD research.
Year(s) Of Engagement Activity 2020
URL https://www.ed.ac.uk/clinical-brain-sciences/research/row-fogo-centre
 
Description UK Stroke Assembly, talk by Prof Joanna Wardlaw: "Stroke and dementia: what research tells us" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give a talk at the UK Stroke Assembly from 13-14 June 2016 in Nottingham, UK. the talk was entitled: "Stroke and dementia: what research tells us".
Year(s) Of Engagement Activity 2016
URL https://www.stroke.org.uk/take-action/uk-stroke-assembly
 
Description UK Stroke Forum Conference, invited lecture by Dr Grant Mair: "Should imaging appearances influence the decision to give alteplase?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dr Grant Mair was invited to give a lecture at the UK Stroke Forum Conference in Liverpool, UK, in December 2015. The title of the lecture was: "Should imaging appearances influence the decision to give alteplase?".
Year(s) Of Engagement Activity 2015