Imaging perfusion deficits and thrombolysis safety and efficacy in acute ischaemic stroke. The Third International
Lead Research Organisation:
University of Edinburgh
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Scientific Abstract|Design: Main trial: IST-3 is an international, prospective, randomised, open, blinded end-point (PROBE) controlled trial of i.v. rt-PA within 6 hours of onset of acute ischaemic stroke (www.ist3.com). Plain CT brain scanning is the prime imaging modality for the main trial. Perfusion study: In centres where MR or CT perfusion are part of routine acute stroke care, the data from patients who have MR diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI), or CT with perfusion (CTP) imaging at baseline before entry in IST3 will be collected and analysed centrally in addition to their non-contrast CT or MR DWI. We will measure infarct growth between baseline and 24-48 hour follow-up imaging, among patients with versus without DWI/PWI or CTP mismatch, with rt-PA versus control in patients with perfusion data. |Setting: Main trial: Hospitals in the UK, Europe, North America, Australia, with stroke units where evidence-based care pathways for stroke (including for administration of rt-PA) are in use. IST-3 currently has 97 active centres (+ 86 who may join) in 12 countries worldwide. Perfusion study: Of these, 12 centres are using MR for baseline assessment instead of CT, eight have already sent 12 MR PWI data and five have sent 23 CTP scans in acute stroke. |Project timetables including recruitment rate: IST-3 Main trial: stops recruitment in late 2011. Recruitment is on target. All regulatory approvals (including Human Research Ethics Committee approvals in 97 centres in 12 countries), randomisation, central data collection are in place. The IST-3-perfusion study: can start immediately. The centres that are already using perfusion imaging are some of the most active in IST-3. |Therefore we estimate that over the next 3 years, in 15 active centres, recruiting between four and eight patients per year each, the perfusion study will include between 100 and 300 patients. Based on scan data received so far, we anticipate a rate of two CTP to one MR PWI although a higher rate of four CTP to one MR DWI is possible. Both will provide valuable data. |Ultimately, we will contribute the perfusion data to an international collaboration performing an individual patient data metaanalysis of perfusion imaging.
Organisations
- University of Edinburgh (Lead Research Organisation)
- Medical University of Warsaw (Collaboration)
- UNIVERSITY OF LEICESTER (Collaboration)
- University of Calgary (Collaboration)
- The Children's Hospital at Westmead (Collaboration)
- John Hunter Hospital (Collaboration)
- Medical University of Gdansk (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- University Hospital Carl Gustav Carus Dresden (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- University of Florence (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- UNIVERSITY OF SYDNEY (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Wintermark M
(2013)
Acute Stroke Imaging Research Roadmap II.
in Stroke
Wardlaw, Joanna
Affordable evidence-based imaging assessment in acute stroke
in 8th World Stroke Conference, 13th October 2012, Brasilia
Alzahrani A
(2023)
Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic Stroke.
in Stroke
Wang X
(2023)
Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial.
in Journal of neurology
Dickie DA
(2018)
Blood pressure variability and leukoaraiosis in acute ischemic stroke.
in International journal of stroke : official journal of the International Stroke Society
Wardlaw, J
Brain imaging and biological markers: can they improve prognostic models to prevent strokes after TIAs? (invited talk)
in 9th World Stroke Conference, 22-25 October 2014, Istanbul, Turkey
Arba F
(2017)
Cerebral White Matter Hypoperfusion Increases with Small-Vessel Disease Burden. Data From the Third International Stroke Trial.
in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Description | STAIR VIII (Stroke Treatment Academic Industry Roundtable) |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a guidance/advisory committee |
Description | Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2) |
Amount | £1,000,000 (GBP) |
Funding ID | TSABHF2015/01 |
Organisation | Stroke Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 02/2016 |
End | 01/2021 |
Description | Cohen Charitable Trust |
Amount | £10,000 (GBP) |
Organisation | The Cohen Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Doctor of Medicine |
Amount | £815 (GBP) |
Organisation | University of Edinburgh |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2012 |
End | 09/2015 |
Description | Enhanced Control of Hypertension and Thrombolysis Stroke Study (STAY ENCHANTED) |
Amount | £209,999 (GBP) |
Funding ID | TSA2015/01 |
Organisation | Stroke Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2016 |
End | 03/2018 |
Description | NIHR EME |
Amount | £1,243,488 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2013 |
End | 06/2016 |
Description | PhD studentship (MRC/CCBS, SINAPSE, Anthony Watson Bequest) |
Amount | £17,078 (GBP) |
Organisation | University of Edinburgh |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | PhD studentship (MRC/CCBS, SINAPSE, Anthony Watson Bequest) |
Amount | £17,078 (GBP) |
Organisation | Government of Scotland |
Department | Scottish Funding Council |
Sector | Public |
Country | United Kingdom |
Start |
Description | Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2): Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial |
Amount | £1,449,092 (GBP) |
Funding ID | CS/14/4/30972 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2015 |
End | 04/2018 |
Description | Real-world Independent Testing of eASPECTS Software (RITeS) |
Amount | £83,716 (GBP) |
Funding ID | STA CR 2017/01 |
Organisation | Stoke Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2019 |
End | 07/2019 |
Description | TSA Clinical Trial Project Grant: "Real-world Independent Testing of eASPECTS Software (RITeS)" |
Amount | £51,716 (GBP) |
Funding ID | TSA CR 2017/01 |
Organisation | Stroke Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2018 |
End | 12/2018 |
Description | TSA Edith Murphy Foundation Senior Clinical Lectureship for Medical Professionals: "Realising the full potential of routinely-available brain imaging to improve treatment of patients with acute stroke." |
Amount | £234,841 (GBP) |
Funding ID | SAL-SMP18/1000 |
Organisation | Stroke Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2018 |
End | 04/2023 |
Title | RapidBrain |
Description | Brain imaging researchers execute complex multistep workflows in their computational analysis. Those workflows often include applications that have very different user interfaces and sometimes use different data formats. A good example is the brain perfusion quantification workflow used at the BRIC (Brain Research Imaging Centre) in Edinburgh. Rapid provides an easy method for creating portlets for computational jobs, and at the same it is extensible. We have exploited this extensibility with additions that stretch the functionality beyond the original limits. These changes can be used by other projects to create their own portals, but it should be noted that the development of such portals involve a greater effort than the required in the regular use of Rapid for creating portlets. In our case it has been used to provide a user-friendly interface for perfusion analysis that covers from volume. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2011 |
Provided To Others? | Yes |
Impact | None as yet. |
URL | http://www.neuroimage.co.uk/SIRS/ |
Title | Systematic Image Review System 2 (SIRS 2) web-based image reading tool |
Description | The Systematic Image Review System (SIRS) Tool is suitable for performing: a) large observer reliability studies of image interpretation b) independent image review for trials or observational studies c) continuing professional development (CPD) and eLearning. Its functionality derives from the need to answer key research or educational issues and to meet the usability criteria defined by professional users of imaging, e.g. radiologists. Although originally designed for radiological images such as CT or MR brain scans, the same technology could be used for the reasons given above for situations where other types of images are used, eg histology, photographs of skin rashes or faces. http://www.neuroimage.co.uk/sirsinfo/ |
Type Of Material | Biological samples |
Year Produced | 2008 |
Provided To Others? | Yes |
Impact | Used to facilitate image reading for multiple studies. |
URL | http://www.neuroimage.co.uk/sirsinfo/ |
Description | ENCHANTED Trial Investigation |
Organisation | University of Leicester |
Department | Department of Health Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Expertise and analysis tools |
Collaborator Contribution | Trial organisation |
Impact | No outcomes or outputs yet because the collaboration only started in 2016. |
Start Year | 2016 |
Description | ENCHANTED Trial Investigation |
Organisation | University of Sydney |
Country | Australia |
Sector | Academic/University |
PI Contribution | Expertise and analysis tools |
Collaborator Contribution | Trial organisation |
Impact | No outcomes or outputs yet because the collaboration only started in 2016. |
Start Year | 2016 |
Description | Francesco Arba, Florence |
Organisation | University of Florence |
Country | Italy |
Sector | Academic/University |
PI Contribution | Access to data, training, supervision of analysis |
Collaborator Contribution | Assessed scans and analysis. |
Impact | Paper submitted to Stroke. Abstract submitted to ESO conference. Submitting PhD thesis including the work. |
Start Year | 2015 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | John Hunter Hospital |
Department | Neurology Clinic |
Country | Australia |
Sector | Hospitals |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | Medical University of Gdansk |
Country | Poland |
Sector | Academic/University |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | Medical University of Warsaw |
Department | Institute of Psychiatry and Neurology |
Country | Poland |
Sector | Academic/University |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | Medical University of Warsaw |
Department | Institute of Psychiatry and Neurology |
Country | Poland |
Sector | Academic/University |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | The Children's Hospital at Westmead |
Country | Australia |
Sector | Hospitals |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | University Hospital Carl Gustav Carus Dresden |
Department | Department of Neuroradiology |
Country | Germany |
Sector | Academic/University |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | Investigator Meeting World Stroke Conference, Brasilia |
Organisation | University of Edinburgh |
Department | School of Molecular and Clinical Medicine Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Collaborator Contribution | Participating in multi-centre scan reading project, processing image data, and testing new analysis methods. |
Impact | Publications as listed |
Start Year | 2011 |
Description | PRACTISE Trial Collaboration |
Organisation | King's College London |
Department | Stroke Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Secured funding for trial of CT angiography and perfusion in routine practice. |
Collaborator Contribution | Design of trial, secured funding, study set up. Please note that amount of contribution currently not known. |
Impact | N/A |
Start Year | 2013 |
Description | PRACTISE Trial Collaboration |
Organisation | University of Glasgow |
Department | Institute of Neuroscience and Psychology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Secured funding for trial of CT angiography and perfusion in routine practice. |
Collaborator Contribution | Design of trial, secured funding, study set up. Please note that amount of contribution currently not known. |
Impact | N/A |
Start Year | 2013 |
Description | STIR Collaboration on Standards for Imaging |
Organisation | National Institutes of Health (NIH) |
Department | National Institute of Neurological Disorders and Stroke (NINDS) |
Country | United States |
Sector | Public |
PI Contribution | Chaired workgroup on revascularisation imaging; drafted text; collected responses; prepared final papers for publication (x2) |
Collaborator Contribution | Contributed data or discussed analyses |
Impact | 2x STIR papers |
Start Year | 2012 |
Description | STIR Collaboration on Standards for Imaging |
Organisation | University of Glasgow |
Department | Stroke Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Chaired workgroup on revascularisation imaging; drafted text; collected responses; prepared final papers for publication (x2) |
Collaborator Contribution | Contributed data or discussed analyses |
Impact | 2x STIR papers |
Start Year | 2012 |
Description | Stroke Thrombolysis Trialists Collaboration |
Organisation | University of Calgary |
Department | The Calgary Stroke Program |
Country | Canada |
Sector | Academic/University |
PI Contribution | data |
Collaborator Contribution | Individual patient data and analysis |
Impact | Three publications: Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Tilley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, del Zoppo GJ, Baigent C, Sandercock P, Hacke W, for the Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014;384: 1929-1935. Whiteley WN, Emberson J, Lees KR, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Olivot JM, Parsons M, Toni D, Toyoda K, Wahlgren N, Wardlaw J, del Zoppo GJ, Sandercock P, Hacke W, Baigent C. Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurol 2016;15:925-933. Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, Grotta JC, Kaste M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Murray GD, Sandercock PAG, Toni D, Toyoda K, Wardlaw JM, Whiteley WN, Baigent C, Hacke W, Howard G. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of nine trials. Stroke 2016;47:2373-2379. |
Start Year | 2013 |
Description | Stroke Thrombolysis Trialists Collaboration |
Organisation | University of Oxford |
Department | Department of Biochemistry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | data |
Collaborator Contribution | Individual patient data and analysis |
Impact | Three publications: Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Tilley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, del Zoppo GJ, Baigent C, Sandercock P, Hacke W, for the Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014;384: 1929-1935. Whiteley WN, Emberson J, Lees KR, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Olivot JM, Parsons M, Toni D, Toyoda K, Wahlgren N, Wardlaw J, del Zoppo GJ, Sandercock P, Hacke W, Baigent C. Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurol 2016;15:925-933. Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, Grotta JC, Kaste M, von Kummer R, Lansberg MG, Lindley RI, Lyden P, Murray GD, Sandercock PAG, Toni D, Toyoda K, Wardlaw JM, Whiteley WN, Baigent C, Hacke W, Howard G. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of nine trials. Stroke 2016;47:2373-2379. |
Start Year | 2013 |
Description | "Alteplase (recombinant tissue Plasminogen Activator, rt-PA) for the Treatment of Acute Ischemic Stroke", Inclusion of a new individual medicine in the 21st edition of the World Health Organization Model List of Essential Medicines (EML) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | "Alteplase (recombinant tissue Plasminogen Activator, rt-PA) for the Treatment of Acute Ischemic Stroke", Inclusion of a new individual medicine in the 21st edition of the World Health Organization Model List of Essential Medicines (EML). Comments from the WHO appraisal Committee are at: https://www.who.int/selection_medicines/committees/expert/22/applications/alteplase/en/ Supporting document to WHO appraisal committee submitted by WSO: https://www.who.int/selection_medicines/committees/expert/22/applications/s12.5.2_alteplase.pdf |
Year(s) Of Engagement Activity | 2018 |
URL | https://apps.who.int/iris/handle/10665/325771 |
Description | "Artificial intelligence software for stroke radiology - Knowledge gaps and issues arising" Royal College of Radiologists Webinar 23 Sept 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | virtual meeting |
Year(s) Of Engagement Activity | 2021 |
Description | "Neurology and Neuroradiology Collaborations to Detect cSVD" 13th World Stroke Organisation Conference 2021, 29 October 2021, virtual. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | virtual meeting |
Year(s) Of Engagement Activity | 2021 |
Description | 'Imaging for vessels and stroke' ERA-NET NEURON Foresight Symposium on Brain-Blood Barrier and Cerebrovascular Diseases. Virtual. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | virtual meeting |
Year(s) Of Engagement Activity | 2021 |
Description | 11° Congresso Português do AVC, talk by Prof Joanna Wardlaw: "Imaging studies in vascular cognitive impairment" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw was invited to give a talk at the 11° Congresso Português do AVC (11th Portuguese Stroke Congress) in Porto, Portugal, on 2 February 2016; the talk was "Imaging studies in vascular cognitive impairment". |
Year(s) Of Engagement Activity | 2017 |
Description | 16th Belgian Stroke Council International Symposium - Prof Joanna Wardlaw participated in a deabte on "Should we still perform a perfusion-CT?" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | At the 16th Belgian Stroke Council International Symposium - a joint symposium of the Belgian Neurological Society and the Belgian Stroke Council, endorsed by the European Stroke Organisation (ESO) - Prof Joanna Wardlaw was asked to participate in a debate on "Should we still perform a perfusion-CT?". Prof Wardlaw advocated for "no". The symposium took place on 2 December 2017 in Leuvan, Belgium. |
Year(s) Of Engagement Activity | 2017 |
Description | Alzheimer's Research UK Manchester and NorthWest Network Centre Science Day, talk by Prof Joanna Wardlaw: "Vascular disease and neurodegeneration - structural and functional insights from neuroimaging in humans" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw was invited to give at talk at the Alzheimer's Research UK Manchester and NorthWest Network Centre Science Day on 18 May 2016, in Manchester, UK. The talk was entitled: "Vascular disease and neurodegeneration - structural and functional insights from neuroimaging in humans". |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.alzheimersresearchuk.org/research-projects/alzheimers-research-uk-manchester-north-west-n... |
Description | American Society of Neuroradiology Annual Meeting, talk by Dr Grant Mair: "CT angiography in acute stroke: a subgroup analysis of the Third International Stroke Trial." |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Grant Mair gave a talk, CT angiography in acute stroke: a subgroup analysis of the Third International Stroke Trial, at the American Society of Neuroradiology Annual Meeting in San Diego, USA in 2013. |
Year(s) Of Engagement Activity | 2013 |
Description | British Institute of Radiology, invited lecture by Dr Grant Mair: "Stroke Imaging: What does the future hold?" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Grant Mair was invited to give a lecture at the British Institute of Radiology, London, UK, in June 2016. The title of the lecture was: "Stroke Imaging: What does the future hold?" |
Year(s) Of Engagement Activity | 2016 |
Description | British Society of Neuroradiologists Annual Meeting, talk by Dr Grant Mair: "Response to intravenous rt-PA in ischaemic stroke patients with and without arterial occlusion on CTA: The Third International Stroke Trial (IST-3)" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Grant Mair gave a talk on "Response to intravenous rt-PA in ischaemic stroke patients with and without arterial occlusion on CTA: The Third International Stroke Trial (IST-3)" at the British Society of Neuroradiologists Annual Meeting in Oxford, UK, in October 2013. |
Year(s) Of Engagement Activity | 2013 |
Description | European Stroke Organisation Conference (ESOC), poster presented by Dr Grant Mair: 'Feasibility of using brain attenuation changes on CT to accurately predict time of ischaemic stroke onset' |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Grant Mair presented a poster at the European Stroke Organisation Conference (ESOC) in Prague, from 16-18 May 2017: Mair G, Sandercock PAG, Wardlaw JM. Feasibility of using brain attenuation changes on CT to accurately predict time of ischaemic stroke onset. European Stroke Journal 2017; 2(IS):252. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.eso-conference.com/2018/useful-links/previous-esoc-conferences#.WldThmsUlHg |
Description | International Centre for Mathematical Sciences Information Geometry Workshop, Dr Grant Mair gave the plenary lecture on: "Medical Imaging of the brain" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Grant Mair gave the plenary lecture at the International Centre for Mathematical Sciences Information Geometry Workshop in Edinburgh, UK, in September 2015. The title of the lecture was: "Medical Imaging of the brain." |
Year(s) Of Engagement Activity | 2015 |
Description | Invited talk - Gdansk Dept of Neurology Festival, 19 May 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited lecture by Professor Wardlaw - "Major Developments in Clinical Neurology" Gdansk Dept of Neurology Festival, 19 May 2022,Virtual. |
Year(s) Of Engagement Activity | 2022 |
Description | Microvascular dysfunction in cerebral small vessel disease: implications for therapeutic approaches, 71st Annual British Microcirculation and Vascular Biology Society Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | virtual seminar |
Year(s) Of Engagement Activity | 2017,2021 |
Description | Prof Joanna Wardlaw feature in Health Matters magazine |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | A feature in Health Matters magazine, Winter 2018-2019 issue, P 24-25. Wardlaw, JM. "MRI scans of the brain". |
Year(s) Of Engagement Activity | 2019 |
Description | Prof Joanna Wardlaw lecture "Brain Health: a small matter of the blood vessels" in Edinburgh, UK. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Edinburgh Neuroscience Public Christmas Lecture 2018 |
Year(s) Of Engagement Activity | 2018 |
Description | Prof Joanna Wardlaw lecture "Neuroimaging in acute ischaemic stroke: history, current and future" in Stockholm, Sweden. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw gave a special lecture on "Neuroimaging in acute ischaemic stroke: history, current and future" at the ESO-Karolinska Stroke Update Conference in Stockholm, Sweden on November 12, 2018. |
Year(s) Of Engagement Activity | 2018 |
Description | Prof Joanna Wardlaw lecture "Where next for stroke research?" in Edinburgh, UK |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | 6th Edinburgh Stroke Winter School, 18th-20th February 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | Prof Joanna Wardlaw talk "What makes a good paper and how to prepare it? Suggestions based on my person experience",Beijing, China |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw talk "What makes a good paper and how to prepare it? Suggestions based on my person experience", at the Tiantan International Stroke Conference 2019, 28 June 2019, Beijing, China |
Year(s) Of Engagement Activity | 2019 |
Description | Prof Joanna Wardlaw talk "Where next for stroke research?" in Edinburgh, UK. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw talk "Where next for stroke research?"at the 6th Edinburgh Stroke Winter School, 19th February 2019, Edinburgh, UK. |
Year(s) Of Engagement Activity | 2019 |
Description | Professor Wardlaw talk titled "Practical brain imaging to identify patients for reperfusion therapies in acute ischaemic stroke", (2019) Tiantan International Stroke Conference, Beijing, China |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Wardlaw talk titled "Practical brain imaging to identify patients for reperfusion therapies in acute ischaemic stroke", (2019) Tiantan International Stroke Conference, Beijing, China |
Year(s) Of Engagement Activity | 2019 |
Description | Recognized as an Expertscape World Expert in the Blood-Brain Barrier. Expertscape's PubMed-based algorithms placed Joanna in the top 0.1% of scholars writing about the Blood-Brain Barrier over the past 10years |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | https://twitter.com/Daily_Experts/status/1417385315556335616 |
Year(s) Of Engagement Activity | 2021 |
Description | Royal College of Physicians 'Women in medicine: a celebration' project |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Royal College of Physicians (RCP)'s 'Women in medicine: a celebration' project is a free exhibition of specially commissioned photographic portraits to honour contemporary and historical women in medicine. The project showcased a number of today's leading female clinicians and the women from the history of medicine who have inspired them. Prof Joanna Wardlaw is featured in the project alongside someone who inspired her, Marie Sklodowska Curie: https://www.rcplondon.ac.uk/projects/outputs/women-medicine-joanna-wardlaw-and-marie-curie |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.rcplondon.ac.uk/events/women-medicine-celebration |
Description | Royal College of Radiologists Research Day, talk by Prof Joanna Wardlaw: "A day in the life of an academic radiologist" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw was invited to give at talk at the Royal College of Radiologists Research Day on 15 November 2016 in London, UK. The talk was entitled, "A day in the life of an academic radiologist". |
Year(s) Of Engagement Activity | 2016 |
Description | SVD Research LinkedIn |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | SVD Research LinkedIn social media channel promoting work of the University of Edinburgh SVD Research groups, including publications, awards, press releases, recent vacancies and other associated activities, aiming to build an international network of professionals specialising in the SVD Research and promote the research to funding bodies, policy makers and industry professionals. |
Year(s) Of Engagement Activity | 2021 |
URL | https://uk.linkedin.com/in/svd-research-5aaa27199 |
Description | Scottish Church Theology Society, talk by Prof Joanna Wardlaw: "The challenges of modern biology - the brain" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Prof Joanna Wardlaw was invited to give a talk at The Scottish Church Theology Society on 12 January 2016 in Peebles, UK. The talk was entitled: "The Challenge of Modern Biology - The Brain". |
Year(s) Of Engagement Activity | 2016 |
Description | Scottish Radiological Society Annual General Meeting, talk by Prof Joanna Wardlaw: "The Role of Acute Imaging in Stroke" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw was invited to give at talk at the Scottish Radiological Society's Annual General Meeting on 11 November 2016 in Dundee, UK. The talk was "The role of acute imaging in stroke". |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.radiology.co.uk/meetings |
Description | Stroke Association's Keynote Lecture given by Prof Joanna Wardlaw "One small vessel stroke? One giant problem for humankind" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | The Stroke Association's Keynote Lecture is a prestigious event that showcases the latest advancements being made in stroke research. In 2016, the Keynote Lecture was held at Lancaster House. Professor Wardlaw addressed 'small vessel disease' which is the most common cause of vascular dementia. Although vascular dementia is the second most common form of dementia, for too long there has been insufficient research into this disease. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.stroke.org.uk/news/keynote-lecture-2016 |
Description | The Row Fogo Centre for Research into Ageing and the Brain website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Being officially recognised as a Research Centre in 2018, The Row Fogo Centre for Research into Ageing and the Brain launched a new website. The website is directed in multiple audiences. Content includes a comprehensive description of the Centre research activity, updates on recent publications, news and organised events. The website contains information for PhD candidates and medical imaging researchers about related programmes and courses, and for visiting staff and students on how to join SVD Research Groups. The website gives a breadth of ways to fundraise and donate to support SVD research. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.ed.ac.uk/clinical-brain-sciences/research/row-fogo-centre |
Description | UK Stroke Assembly, talk by Prof Joanna Wardlaw: "Stroke and dementia: what research tells us" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Joanna Wardlaw was invited to give a talk at the UK Stroke Assembly from 13-14 June 2016 in Nottingham, UK. the talk was entitled: "Stroke and dementia: what research tells us". |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.stroke.org.uk/take-action/uk-stroke-assembly |
Description | UK Stroke Forum Conference, invited lecture by Dr Grant Mair: "Should imaging appearances influence the decision to give alteplase?" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Dr Grant Mair was invited to give a lecture at the UK Stroke Forum Conference in Liverpool, UK, in December 2015. The title of the lecture was: "Should imaging appearances influence the decision to give alteplase?". |
Year(s) Of Engagement Activity | 2015 |
Description | World Stroke Organisation Women in Stroke Initiative, 2021, showcasing the work of women who have made major contributions to advancing care of patients with stroke |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | https://www.world-stroke.org/news-and-blog/blogs/womeninstroke-initiative-our-nominees |
Year(s) Of Engagement Activity | 2021 |