Efficacy and mechanism of thyroxine treatment on pregnancy and neonatal outcomes in women with thyroid antibodies:
Lead Research Organisation:
Birmingham Women’s & Children’s NHS FT
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Scientific Abstract|We conducted a systematic review exploring the association between thyroid antibodies and adverse pregnancy outcomes. For miscarriage, we identified 29 studies (9817 women), and 26 of these showed a positive association. Meta-analysis of the 29 studies showed more than doubling in the odds of miscarriage in the presence of thyroid antibodies (OR:2.4, 95% CI: 1.9, 3.1). For preterm birth, we identified 4 studies (2896 women). All studies showed a positive association and meta-analysis found more than doubling in the odds of preterm birth in the presence of thyroid antibodies (OR: 2.7, 95% CI: 1.9, 3.9). The two dominant hypotheses for these observations are that a) thyroid antibodies represent a state of global immune dysfunction and b) thyroid antibodies are associated with relative thyroid insufficiency. There is evidence that thyroxine treatment can alter global immune response directly, and it can also correct any relative thyroid insufficiency. We carried out another systematic review to identify studies of thyroxine replacement to improve pregnancy outcomes in women with thyroid antibodies: two randomised trials, including a total of 187 women, were identified; the studies showed a reduction in miscarriages (RR: 0.48, 95% CI:0.25, 0.92) and preterm birth (RR:0.31; 95% CI:0.11, 0.90) with levothyroxine treatment. However, our UK clinician survey (n=183) found that only 8% (15/183) of clinicians use or intend to use levothyroxine for the prevention of miscarriages in thyroid antibody positive women and that 85% (155/183) do not currently use levothyroxine, but would be willing to recruit into a randomised study.|We, therefore, propose a randomised, placebo-controlled, double-blind, multi-centre trial to test the hypothesis that in euthyroid women with thyroid peroxidase antibodies, levothyroxine (50mcg, oral, once daily), started pre-conceptually and continued to the end of pregnancy, compared with placebo, increases live births beyond 34 completed weeks of gestation by at least 10%. Nested within the trial, we will evaluate cytokine levels in the maternal circulation and decidua. We plan to randomise 900 women (450 participants in each arm): To detect a 10% difference in live birth beyond 34 weeks, for an alpha of 5% and power of 80%, 380 women will need to be randomised to each group. However, assuming and adjusting for a worst case scenario of a 15% attrition, the total number of participants required will be 900. The analysis will be by intention to treat, and according to a pre-specified analysis plan. The trial will be co-ordinated by an Accredited Clinical Trials Unit. Twenty one hospitals in the UK will participate in this trial, which will be led by a strong team of researchers with track record in conducting multicentre trials as well as miscarriage, preterm birth and thyroid research. The trial is supported by patients (78 interviewed), Miscarriage Association, British Thyroid Foundation, British Thyroid Association, the RCOG and others. If our study confirms the benefits shown in the existing trials, the NHS can save over £215 million/year.|
Organisations
- Birmingham Women’s & Children’s NHS FT (Lead Research Organisation)
- Miscarriage Association (Collaboration)
- University of Warwick (Collaboration)
- Furness General Hospital (Collaboration)
- Association of Early Pregnancy Units (Collaboration)
- Birmingham Heartlands Hospital (Collaboration)
- Derriford Hospital (Collaboration)
- New Cross Hospital (Collaboration)
- University College Hospital (Collaboration)
- Burnley General Hospital (Collaboration)
- Birthrights (Collaboration)
- Watford General Hospital (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- Warrington and Halton Hospitals NHS Foundation Trust (Collaboration)
- Princess Royal Hospital (Collaboration)
- North Cumbria University Hospitals NHS Trust (Collaboration)
- COUNTY DURHAM AND DARLINGTON NHS FOUNDATION TRUST (Collaboration)
- Heart of England NHS Foundation Trust (Collaboration)
- Guy's Hospital (Collaboration)
- Royal College of Nursing (Collaboration)
- Countess of Chester Hospital (Collaboration)
- James Lind Alliance (Collaboration)
- Royal Derby Hospital (Collaboration)
- Saint Mary's Hospital, Manchester (Collaboration)
- Imperial College Healthcare NHS Trust (Collaboration)
- Frimley Park Hospital (Collaboration)
- Royal Devon and Exeter Hospital (Collaboration)
- International Society of Ultrasound in Obstetrics and Gynecology (Collaboration)
- BOLTON NHS FOUNDATION TRUST (Collaboration)
- St Thomas' Hospital (Collaboration)
- St Mary's Hospital, London (Collaboration)
- West Middlesex University Hospital (Collaboration)
- ASHFORD AND ST. PETER'S HOSPITALS NHS FOUNDATION TRUST (Collaboration)
- Crosshouse Hospital (Collaboration)
- Wirral University Teaching Hospital NHS Foundation Trust (Collaboration)
- TOMMY'S (Collaboration)
- Queen's Medical Centre (Collaboration)
- UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST (Collaboration)
- University Hospital Coventry (Collaboration)
- St James's University Hospital (Jimmy's) (Collaboration)
- Liverpool Womens NHS Foundation Trust (Collaboration)
- Sunderland Royal Hospital (Collaboration)
- Birmingham Women's and Children's NHS Foundation Trust (Collaboration)
- Birmingham Women's Hospital (Collaboration)
- Ectopic Pregnancy Trust (Collaboration)
- Ealing Hospital (Collaboration)
- Colchester Hospital University NHS Foundation Trust (Collaboration)
- Bradford Teaching Hospitals NHS Foundation Trust (Collaboration)
- St Michael's Hospital (Collaboration)
- Queen Charlotte's and Chelsea Hospital (Collaboration)
- Netmums Ltd (Collaboration)
- King's College Hospital (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- Royal United Hospital (Collaboration)
- Birmingham City Hospital (Collaboration)
- BARTS HEALTH NHS TRUST (Collaboration)
- Scottish Care & Information On Miscarriage (Collaboration)
- The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust (Collaboration)
- Nurture Fertility (Collaboration)
- Basildon University Hospital (Collaboration)
- Mumsnet (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- James Cook University Hospital (Collaboration)
- Royal Victoria Infirmary (Collaboration)
- North Manchester General Hospital (Collaboration)
- Wellbeing of Women (Collaboration)
- Royal College of Obstetricians and Gynaecologists (RCOG) (Collaboration)
- Royal College of General Practitioners (Collaboration)
- ROYAL CORNWALL HOSPITALS NHS TRUST (Collaboration)
- Wrightington, Wigan and Leigh NHS Foundation Trust (Collaboration)
People |
ORCID iD |
Aravinthan Coomarasamy (Principal Investigator) |
Publications
Dhillon-Smith RK
(2020)
TPO antibody positivity and adverse pregnancy outcomes.
in Best practice & research. Clinical endocrinology & metabolism
Dhillon-Smith RK
(2020)
The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility.
in The Journal of clinical endocrinology and metabolism
Craciunas L
(2023)
The metabolomic profile of endometrial receptivity in recurrent miscarriage.
in Minerva obstetrics and gynecology
Dhillon-Smith RK
(2022)
Subclinical hypothyroidism and antithyroid autoantibodies in women with subfertility or recurrent pregnancy loss: Scientific Impact Paper No. 70 June 2022: Scientific Impact Paper No. 70 June 2022.
in BJOG : an international journal of obstetrics and gynaecology
Dhillon-Smith R
(2019)
Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCT
in Efficacy and Mechanism Evaluation
Dhillon-Smith RK
(2019)
Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.
in The New England journal of medicine
Gill S
(2023)
Evaluating the Progression to Hypothyroidism in Preconception Euthyroid Thyroid Peroxidase Antibody-Positive Women
in The Journal of Clinical Endocrinology & Metabolism
Holt-Kentwell A
(2022)
Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review.
in Human reproduction update
Smith P
(2017)
Core Outcome Sets in Miscarriage Trials (COSMisT) study: a study protocol.
in BMJ open
Thangaratinam S
(2011)
Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence.
in BMJ (Clinical research ed.)
Title | Digital Awareness Raising Campaign for Miscarriage Research |
Description | My team produced a series of videos, outdoor advertisements and digital promotions under the "Birmingham Heroes" brand, to raise awareness of our efforts to target the challenges and misconceptions of miscarriage research. |
Type Of Art | Film/Video/Animation |
Year Produced | 2016 |
Impact | Between April and June 2016, maternal health research became the highest scoring press theme of the academic year at the University of Birmingham. Overall, the campaign delivered approximately 1,200 website link clicks from 550,000 impressions. Facebook advertising was particularly effective, with over 600 link clinks generated from 50,000 impressions. On average people visited 2 webpages per session. The Twitter advertisement was retweeted 95 times. Our most popular advertisement strapline was "we are leading the largest early miscarriage centre in Europe." The campaign received praise and support on a variety of social media sites, from a variety of stakeholders including patients and families, students, academic peers, charities, professional practitioners and the Minister for Care Quality Ben Gummer. |
Title | Forget Me Not campaign item 1 |
Description | In 2017 my team collaborated with colleagues at the University of Birmingham to coordinate a campaign to raise more than £70,000 in support of miscarriage studies. The campaign included personalised electronic and hard copy letters to alumni all over the world, three videos (hundreds of views) and specially produced seed papers to grow forget-me-not flowers in honour of pregnancies ended too soon. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
Impact | Many alumni responded by sending in letters of appreciation or writing about their own stories. We not only achieved more than £70,000 income to pursue more life-changing research that could not otherwise be realised: the team also brought hope to thousands of families affected by the heartache of pregnancy loss and demonstrated our commitment to challenge the social stigma of miscarriage. One of the couples who participated in the project said "knowing there are people out there researching early miscarriage gives couples hope and belief when sometimes there are no answers available." One of the alumni who donated to the project said "I am full of admiration for their work and wish them continued success." |
URL | http://www.birmingham.ac.uk/alumni/Giving/Health-and-medical-research/Miscarriage.aspx |
Title | Forget Me Not campaign item 2 |
Description | In 2017 my team collaborated with colleagues at the University of Birmingham to coordinate a campaign to raise more than £70,000 in support of miscarriage studies. The campaign included personalised electronic and hard copy letters to alumni all over the world, three videos (hundreds of views) and specially produced seed papers to grow forget-me-not flowers in honour of pregnancies ended too soon. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
Impact | Many alumni responded by sending in letters of appreciation or writing about their own stories. We not only achieved more than £70,000 income to pursue more life-changing research that could not otherwise be realised: the team also brought hope to thousands of families affected by the heartache of pregnancy loss and demonstrated our commitment to challenge the social stigma of miscarriage. One of the couples who participated in the project said "knowing there are people out there researching early miscarriage gives couples hope and belief when sometimes there are no answers available." One of the alumni who donated to the project said "I am full of admiration for their work and wish them continued success." |
URL | https://www.youtube.com/watch?v=vqg0gv-8XlA |
Title | Forget Me Not campaign item 3 |
Description | In 2017 my team collaborated with colleagues at the University of Birmingham to coordinate a campaign to raise more than £70,000 in support of miscarriage studies. The campaign included personalised electronic and hard copy letters to alumni all over the world, three videos (hundreds of views) and specially produced seed papers to grow forget-me-not flowers in honour of pregnancies ended too soon. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
Impact | Many alumni responded by sending in letters of appreciation or writing about their own stories. We not only achieved more than £70,000 income to pursue more life-changing research that could not otherwise be realised: the team also brought hope to thousands of families affected by the heartache of pregnancy loss and demonstrated our commitment to challenge the social stigma of miscarriage. One of the couples who participated in the project said "knowing there are people out there researching early miscarriage gives couples hope and belief when sometimes there are no answers available." One of the alumni who donated to the project said "I am full of admiration for their work and wish them continued success." |
URL | https://www.youtube.com/watch?v=ooDv-yojo2E |
Title | Tommys National Centre for Miscarriage Research |
Description | We created a film, animation and soundtrack to explain the key questions asked by women and couples who experience a miscarriage: Why did it happen? Will it happen again? Can we prevent it happening again? How can we come to terms with this? |
Type Of Art | Film/Video/Animation |
Year Produced | 2015 |
Impact | This video contributed to the successful application of my team to lead Tommy's National Centre for Miscarriage Research. |
Description | House of Commons roundtable discussion |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | I delivered a Tommy's charity petition to Downing Street. The petition has over 250,000 signatures and is calling for the following recommendations from the Lancet series to be built into the women's health strategy: • Support should be available after every miscarriage in line with the graded model of care. • Mental health support should be available after each loss, as those who have suffered miscarriage are at a higher risk of developing anxiety, depression, post-traumatic stress disorder, and of suicide. • An end to the postcode lottery: tests and treatments must be standardised across the UK. • All miscarriages must be formally recorded as this information is required to inform our research. |
Description | Pregnancy Loss Review Oversight Committee |
Geographic Reach | National |
Policy Influence Type | Participation in a guidance/advisory committee |
Impact | The Committee is responsible for enacting recommendations of the Pregnancy Loss Review, which involved the piloting and potential national roll out of a graded model of care for miscarriage, being developed and piloted by Prof Coomarasamy's team. The Committee is led by Parliamentary Under-Secretary of State for Health and Social Care, Maria Caulfield MP |
URL | https://www.parallelparliament.co.uk/debate/2023-10-19/commons/written-statements/pregnancy-loss-rev... |
Description | Pregnancy Loss Review Panel |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | The Pregnancy Loss Review panel will publish in Q2 of 2023, and will incorporate recommendations from The Lancet miscarriage series. |
Description | Tommy's Miscarriage Support Tool |
Geographic Reach | National |
Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
Impact | Provides personalised information and support to women at risk of miscarriage to raise awareness and reduce risk of miscarriage which affects 15% of pregnancies. Information within the tool is based on research from the Tommy's National Centre for Miscarriage Research, of which Prof Coomarasamy is the Director |
URL | https://www.miscarriagetool.tommys.org/?gad_source=1&gclid=EAIaIQobChMI8OHC7I_dhAMVK0t_AB3PGgBwEAAYA... |
Description | DARO Forget-Me-Not |
Amount | £72,000 (GBP) |
Organisation | University of Birmingham |
Sector | Academic/University |
Country | United Kingdom |
Start | 07/2017 |
Description | Evaluating the use of levothyroxine treatment to reduce miscarriage in women with mild thyroid dysfunction: an individual patient data meta-analysis. |
Amount | £14,972,253 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
Description | Tommy's National Centre for Miscarriage Research 2023-2024 |
Amount | £500,000 (GBP) |
Organisation | Tommy's |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2023 |
End | 03/2024 |
Title | Miscarriage PSP |
Description | I was involved in the Miscarriage Priority Setting Partnership (PSP). This project aimed to establish what miscarriage research topics are important to women and those affected by miscarriage, as well as what miscarriage research topics are important to professionals. |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | The results of the project are shaping the miscarriage research agenda and acting as a catalyst for more funding opportunities for research in this area. |
URL | http://miscarriagepsp.org/ |
Description | Miscarriage PSP |
Organisation | Association of Early Pregnancy Units |
Country | United Kingdom |
Sector | Learned Society |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Birthrights |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Ectopic Pregnancy Trust |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Heart of England NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | International Society of Ultrasound in Obstetrics and Gynecology |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | James Lind Alliance |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Miscarriage Association |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Mumsnet |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Netmums Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Nurture Fertility |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Royal College of General Practitioners |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Royal College of Nursing |
Country | United Kingdom |
Sector | Private |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Royal College of Obstetricians and Gynaecologists (RCOG) |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Scottish Care & Information On Miscarriage |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | St Mary's Hospital, London |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Sunderland Royal Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Tommy's |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | University of Birmingham |
Department | Department of Finance |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | University of Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | Miscarriage PSP |
Organisation | Wellbeing of Women |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | I contributed to several meetings of the Miscarriage Priority Setting Partnership (PSP) steering group committee, offering expertise and opinion, to establish what miscarriage research topics are most important for those affected by miscarriage. |
Collaborator Contribution | The Miscarriage Priority Setting Partnership (PSP) helped women and those affected by miscarriage to work together with clinicians, to agree which are the most important questions that need to be answered by miscarriage research. |
Impact | The questions prioritised by stakeholders were published in 2017: DOI 10.1136/bmjopen-2017-016571. |
Start Year | 2016 |
Description | TABLET |
Organisation | Ashford and St. Peter's Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Barts Health NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Barts Health NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Barts Health NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Barts Health NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Basildon University Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Birmingham City Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Birmingham Heartlands Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Birmingham Women's and Children's NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Bolton NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Burnley General Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Colchester Hospital University NHS Foundation Trust |
Department | Colchester General Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Countess of Chester Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | County Durham and Darlington NHS Foundation Trust |
Department | University Hospital of North Durham |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Crosshouse Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Derriford Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Ealing Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Frimley Park Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Furness General Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Guy's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Imperial College Healthcare NHS Trust |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | James Cook University Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | King's College Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Liverpool Womens NHS Foundation Trust |
Department | Liverpool Women's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | New Cross Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | North Cumbria University Hospitals NHS Trust |
Department | Cumberland Infirmary |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | North Manchester General Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Princess Royal Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Queen's Medical Centre |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Royal Cornwall Hospitals NHS Trust |
Department | Royal Cornwall Hospital (Treliske) |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Royal Derby Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Royal Devon and Exeter Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Royal United Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Royal Victoria Infirmary |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Saint Mary's Hospital, Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | St James's University Hospital (Jimmy's) |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | St Mary's Hospital, London |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | St Michael's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | St Thomas' Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust |
Department | Royal Bournemouth Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Tommy's |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | University College Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | University Hospital Coventry |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Warrington and Halton Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Watford General Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | West Middlesex University Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Wirral University Teaching Hospital NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | TABLET |
Organisation | Wrightington, Wigan and Leigh NHS Foundation Trust |
Department | Wrightington Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | My research team provided all the coordination necessary to conduct this clinical trial, including site initiation and governance. |
Collaborator Contribution | Each research site provided the staff and clinical resources to recruit patients and collect research data. Tommy's provides a platform for collaboration and dissemination. |
Impact | In 2011 my team published a meta-analysis of evidence to suggest association between thyroid autoantibodies and miscarriage and preterm birth: DOI 10.1136/bmj.d2616. We expect to publish the findings of the TABLET trial designed in response to this evidence in the coming years. |
Start Year | 2011 |
Description | Tommys |
Organisation | Birmingham Women's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Description | Tommys |
Organisation | Imperial College London |
Department | Department of Earth Science & Engineering |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Description | Tommys |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Description | Tommys |
Organisation | Queen Charlotte's and Chelsea Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Description | Tommys |
Organisation | Tommy's |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Description | Tommys |
Organisation | University Hospitals Coventry and Warwickshire NHS Trust |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Description | Tommys |
Organisation | University of Warwick |
Department | Warwick Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | As the Director of Tommy's National Centre for Miscarriage Research, I drive an innovative programme of people-based research to deliver meaningful clinical impact, leveraging major institutional investment alongside that of Tommy's to enable new collaborative, multidisciplinary working. The research is designed to focus of 4 key themes emerging from the questions asked by those who suffer miscarriages: Why did it happen? Will it happen again? Can we prevent it happening again? How can we bear it emotionally and move forward from here? |
Collaborator Contribution | Tommy's National Centre for Miscarriage Research brings together 3 universities and 4 hospitals. Each site provides the staff, research infrastructure and facilities to recruit patients and collect research data. Tommy's provides professional assistance to raise national awareness of the research, promoting recruitment to the clinical studies and fundraising widely for maternal health studies. |
Impact | Outputs are listed in other sections of the form. |
Start Year | 2015 |
Title | Levothyroxine to reduce miscarriage risk in euthyroid women with thyroid auto-antibodies |
Description | Financially supported by the NIHR EME competition, the TABLET trial (ISRCTN 15948785, EudraCT 2011-000719-19) sought to evaluate the effects of thyroxine to prevent miscarriage in women with thyroid antibodies but normal thyroid function. The trial was carried out at more than 30 centres across the UK. |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2011 |
Development Status | Under active development/distribution |
Impact | Please refer to other sections of the portfolio for further details. |
URL | http://www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/womens/tablet/index |
Description | AEPU 2015 - TABLET |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The AEPU conference is an annual event that brings together hundreds of researchers, healthcare practitioners and policy makers to build collaborations and raise the profile of early pregnancy care. In 2015 I presented the work of my team to conference delegates, and other team members operated a stall to promote the TABLET trial. |
Year(s) Of Engagement Activity | 2015 |
Description | AEPU 2016 - TABLET |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The AEPU conference is an annual event that brings together hundreds of researchers, healthcare practitioners and policy makers to build collaborations and raise the profile of early pregnancy care. In 2016 my team presented TABLET news to conference delegates and operated a stall to promote the trial. |
Year(s) Of Engagement Activity | 2016 |
Description | AEPU 2017 - Miscarriage Trials |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The AEPU conference is an annual event that brings together hundreds of researchers, healthcare practitioners and policy makers to build collaborations and raise the profile of early pregnancy care. In 2017 my team presented news of all our active clinical trials (in the United Kingdom) to conference delegates, and operated a stall to promote the studies. |
Year(s) Of Engagement Activity | 2017 |
Description | BBC Yorkshire interview about miscarriage 2018 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Steve Bailey, BBC Journalist for Radio Yorkshire, interviewed Professor Coomarasamy for a feature about miscarriage experiences and management. |
Year(s) Of Engagement Activity | 2018 |
Description | British Thyroid Foundation - TABLET |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | News of the TABLET trial was reported via the British Thyroid Foundation website. The British Thyroid Foundation website brings news of the TABLET Trial to patient groups and the public. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016 |
URL | http://www.btf-thyroid.org/ |
Description | CRNs - TABLET |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | My research team engages with CRNs across the UK. CLRNs are providing support to the TABLET Trial. Many CLRNs are contributing to the costs of clinical testing, and some CLRNs are contributing nursing support, and/or assisting my research team to identify appropriate healthcare staff to work with us. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017,2018 |
Description | Clinical Trials Presentation at IMSR Away Day 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I was invited to deliver a presentation entitled "Translating Science into Health - Clinical Trials" to the Institute of Metabolism and Systems Research (IMSR) at the University of Birmingham. Questions and discussions increased awareness and interest in the subject. |
Year(s) Of Engagement Activity | 2016 |
Description | Debate for British Thyroid Association - TABLET |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | In October 2010 at the Annual Meeting of the British Thyroid Association in London, Professor Mark Kilby took part in a national debate to contest whether the reproductive health of women with anti-TPO antibodies may be improved by treatment with thyroxine prior and during pregnancy. Professor Mark Kilby argued for this motion, and Professor Tony Weetman argued against it. The debate sparked audience participation and discussion afterwards. The debate stimulated thinking and active consideration of the hypothesis among professional practitioners. |
Year(s) Of Engagement Activity | 2010 |
Description | Early Pregnancy Research Presentation to the Gynaecology Club |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | The Gynaecology Club hosts a series of events and meetings attended by consultants, junior doctors and researchers from across the Midlands. I was invited to deliver a presentation about early pregnancy research. |
Year(s) Of Engagement Activity | 2016 |
Description | Facebook - TABLET 1 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | News of the TABLET trial was reported via facebook during the early period of the study. The study gained hundreds of 'likes' from assorted participants in the research and other supporters. The TABLET Trial has gained 59 'Likes' from assorted participants in the research and other supporters. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014 |
URL | https://www.facebook.com/TabletTrial?ref=stream |
Description | Facebook - TABLET 2 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Between October and November 2015 we harnessed facebook to increase participant recruitment (using a web platform www.tabletstudy.co.uk as a screening tool) nationwide. |
Year(s) Of Engagement Activity | 2015 |
URL | https://www.tabletstudy.co.uk |
Description | Infertility UK - TABLET |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | News of the TABLET trial was reported via the Infertility UK website. The Infertility UK website brings news of the TABLET Trial to patient groups and the public. |
Year(s) Of Engagement Activity | 2006,2011,2012,2013,2014,2015 |
URL | http://www.infertilitynetworkuk.com/ |
Description | Meeting of Collaborators - TABLET 2015 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | The TABLET Collaborators' Meeting in 2015 brought together researchers from across the UK to share news and ideas, and gain inspiration to reach the culmination of the study. |
Year(s) Of Engagement Activity | 2015 |
Description | Midlands Academy of Medical Sciences Research Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote lecture on miscarriage |
Year(s) Of Engagement Activity | 2022 |
Description | Miscarriage Association - TABLET |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | A representative of the Miscarriage Association - who participates in meetings of the TABLET Trial Steering Committee - regularly reports our news of the project via the Miscarriage Association website and meetings of this organisation. The Miscarriage Association brings news of the TABLET Trial to patient groups and the public. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017,2018 |
URL | http://www.miscarriageassociation.org.uk/ |
Description | Miscarriage presentation to the RCOG World Congress in Obstetrics and Gynaecology 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The RCOG World Congress welcomes scientific and healthcare practitioners from the UK and overseas with a programme of lectures, lively debates and networking opportunities. I was invited to deliver a presentation about the "Mechanisms and Trials of Recurrent Miscarriage" within the early pregnancy workstream. |
Year(s) Of Engagement Activity | 2016 |
Description | Miscarriage research presentation to Tommy's Charity trustees |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Miscarriage research presentation to Tommy's Charity trustees on 19-Sept-2023 |
Year(s) Of Engagement Activity | 2023 |
Description | Newsletters - TABLET |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | Newsletters were issued regularly to TABLET researchers, to keep everybody abreast of progress and build staff morale. Participants have expressed appreciation of newsletters and researchers have engaged in friendly competition in rates of recruitment between sites (performance in the TABLET Olympics reported in each issue), boosting our overall rate of progress. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016 |
Description | Northern Nurses conference presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on 'How to prevent a miscarriage' at the Northern Nurses conference, Leeds (28-Jul-2023). |
Year(s) Of Engagement Activity | 2023 |
Description | PREIS School conference, Florence, Italy - Latest evidence on miscarriage care |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Latest evidence on miscarriage care |
Year(s) Of Engagement Activity | 2022 |
Description | Participant Contact - TABLET |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | I telephoned ladies who have declined to participate in the TABLET trial, to gain an understanding of the reasons. Our improved understanding of the reasons for potential participants to decline to join the TABLET Trial is enabling us to better address and overcome these issues, to improve our recruitment rates. |
Year(s) Of Engagement Activity | 2012,2013,2014,2015 |
Description | Patient Information Sheet - TABLET |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | A lay representative of the Miscarriage Association assisted the design and contents of our Patient Information Sheets. The feedback of a lay representative of the Miscarriage Association has improved the design and contents of our Patient Information Sheets, to enable participants to better understand the TABLET Trial. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016 |
Description | Prediction and Prevention of Miscarriage Presentation to the British Fertility Society (BFS), Edinburgh |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Organised by the Association of Clinical Embryologists (ACE), the British Fertility Society (BFS) and the Society for Reproduction and Fertility (SRF), this fertility conference drew an audience of scientists, clinicians, embryologists, nurses and counsellors. The conference encouraged networking, collaboration and discussion. I presented a keynote speech entitled "Prediction and Prevention of Miscarriage" to conference delegates. |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation of Lancet series findings to the Maternity Transformation Stakeholder Council- July 2021 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Presentation of Lancet series findings to the Maternity Transformation Stakeholder Council- July 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Presentation to GVS - TABLET |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 40 members of the Gynaecological Visiting Society attended a talk about the prevalence of thyroid antibodies and thyroid dysfunction of women of reproductive age in the UK. Conference delegates congratulated the TABLET team for determination, positivity and persistance in the face of practical challenges to meet recruitment targets. |
Year(s) Of Engagement Activity | 2014 |
Description | Presentations to the Specialists in Sharing Expertise, Education and Data (SEED) Conference, Australia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | SEED is a highly respected symposium for fertility doctors. I presented "Recurrent Miscarriage: Definitions and Management" and "Progesterone in the Management of Miscarriage" at the annual meeting in Sydney, Australia. |
Year(s) Of Engagement Activity | 2017 |
Description | Press activities surrounding miscarriage research |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Tommy's Centre for Miscarriage Research has achieved considerable local, national and international press coverage to raise awareness and engagement in miscarriage research. Examples of media exposure include: BBC Breakfast; BBC Radio 4; BBC Five Live; Articles in the Daily Mail Newspaper and The Daily Mirror Newspaper. |
Year(s) Of Engagement Activity | 2016,2017,2018 |
Description | RCOG Virtual World Congress June 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation given on - Miscarriage, where are we going ? |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.rcog.org.uk/en/courses-exams-events/rcog-world-congress/virtual-world-congress/programme... |
Description | RCOG World Congress 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on the latest evidence for miscarriage care |
Year(s) Of Engagement Activity | 2022 |
Description | REACH Newsletters - TABLET |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | Yes |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | The TABLET trial was regularly mentioned in REACH newsletters. The REACH network also provided leadership and support in engaging with CRNs. Health professionals across the region are aware of the TABLET Trial, and several new healthcare institutions have volunteered to become involved in the study. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015 |
URL | http://www.crncc.nihr.ac.uk/about_us/ccrn/bbc/lsg/reproductive_health |
Description | Roundtable discussion event in the House of Commons about miscarriage care |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | The purpose of the event was to bring together a group of parliamentarians to inform them about the issue of miscarriage, tell them about the work Tommy's does, and to inspire them to take action by calling on the government to improve the support available for families. |
Year(s) Of Engagement Activity | 2022 |
Description | Scientific meeting of Tommys National Centre for Miscarriage Research, February 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | My team hosted a scientific meeting for early pregnancy researchers from Tommy's sites around the country. The event enabled junior and senior colleagues in disparate locations to share knowledge, ideas and peer support. |
Year(s) Of Engagement Activity | 2017 |
Description | Tommy's Scientific Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Tommy's Scientific Meeting |
Year(s) Of Engagement Activity | 2022 |
Description | Tommys National Centre for Miscarriage Research Launch |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | In April 2016 we launched Tommy's National Centre for Miscarriage Research. Events in London and Coventry were spearheaded by academic team leaders, celebrity guest speakers and patrons of Tommy's charity. We gained tremendous national media exposure and raised awareness of our efforts to understand miscarriage. |
Year(s) Of Engagement Activity | 2016 |
Description | Tommys misCOURAGE campaign |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Despite one in four pregnancies ending in miscarriage, the silence around the subject means that many couples who have lost babies harbour unexpressed feelings of failure, isolation and guilt. This campaign seeks to tell the stories of all those who have experienced miscarriage. |
Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
URL | https://www.tommys.org/miscourage |
Description | Twitter - TABLET |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Regular tweets - whenever a new patient was randomised - kept our study participants abreast of progress. This engagement builds staff morale and helps to maintain recruitment momentum. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015 |
Description | Website - TABLET |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The TABLET trial maintains an active website. Participants in the TABLET Trial and any other interested members of the public are able to verify the details of the project easily at any time. |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017,2018 |
URL | http://www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/womens/tablet/index.aspx |