University of Birmingham MRC Proximity to Discovery: Open Innovation Through Local Integration

Lead Research Organisation: University of Birmingham

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The MRC Proximity to Discovery scheme awards universities funds to help develop new collaborations, and ways of exchanging knowledge and skills.  The awards can be used to support activities that promote the value of academic-industry partnership, and enhance academic and industry researchers’ understanding of each other’s needs and capabilities.  This may be through people exchanges, creation of technology demonstrators, showcase events, commercialisation workshops and ‘entrepreneurs in residence’ schemes.  Such exchanges of knowledge and skills will boost the most fruitful collaborations between UK universities and life science companies.

Publications

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Parker R (2018) CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease. in American journal of physiology. Gastrointestinal and liver physiology

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Marttila-Ichihara F (2017) Amine oxidase activity regulates the development of pulmonary fibrosis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

 
Description Mechanistic Insights Into Aberrant Transcriptional Programming In Acute Myeloid Leukaemia
Amount £1,543,859 (GBP)
Organisation Bloodwise 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2015 
End 12/2020
 
Description NIHR Biomedical Research Centre
Amount £12,120,962 (GBP)
Organisation Government of Catalonia 
Department Department of Health
Sector Public
Country Spain
Start 04/2017 
End 03/2022
 
Description BCTI 
Organisation Bio-Cancer Treatment International
Country Hong Kong 
Sector Private 
PI Contribution Scientific rationale for preclinical studies and clinical trials Processing of samples from clinical trials Biology
Collaborator Contribution Gift of BCT-100 drug Sponsorship / participation/ provision of drug for patients in US FDA Solid Tumour Phase I trial, LI1 AML Phase II trial, PARC Phase II trial
Impact US FDA Solid Tumour Phase I trial LI1 AML Phase II trial PARC Phase II trial Fultang et al. Can Res 2019 Mussai et al. Int J Cancer 2019 De Santo et al. Int J Cancer 2018 Vardon et al. Oncotarget 2017
Start Year 2016
 
Description Communicate novel UoB purification methodology and its applications for membrane protein research/drug discovery 
Organisation Sanofi
Country Global 
Sector Private 
PI Contribution Established good working relationships with three research groups within Sanofi Genzyme (including proof-of-principle experiments) Successfully co-applied for EPSRC/HEIF funding to dedicate 6 months of post-doctoral time to these efforts (£65k) Findings were presented at internal North American Sanofi Genzyme conference (Sept '16)
Collaborator Contribution Agreement-in-principle to apply jointly for a MIBTP iCASE PhD studentship
Impact Established good working relationships with three research groups within Sanofi Genzyme (including proof-of-principle experiments) Successfully co-applied for EPSRC/HEIF funding to dedicate 6 months of post-doctoral time to these efforts (£65k) Findings were presented at internal North American Sanofi Genzyme conference (Sept '16)
Start Year 2015
 
Description Research fellowship 
Organisation Albert Ludwig University of Freiburg
Country Germany 
Sector Academic/University 
PI Contribution EU funded research fellowship for Nico Buettner to visit our laboratory for 2 years
Collaborator Contribution Funded research fellow
Impact Conference presentation Publications in preparation
Start Year 2014
 
Title Antimicrobial surface 
Description Provided is a nitrided metal surface functionalized with molecules, each molecule comprising at least one binding group and an antimicrobial moiety. The molecules are immobilized on the surface by only covalent interactions between the binding groups of the molecules and nitrogen atoms within the nitrided metal surface. Articles comprising the functionalized nitrided surface find use in inhibiting or reducing the growth of microorganisms on surfaces that are frequently touched. A method for preparing the functionalized nitrided surface comprises contacting a nitrided metal surface with molecules so as to form covalent bonds between the binding groups of the molecules and the nitrogen atoms in the surface, thereby immobilising the molecules on the metal surface. 
IP Reference WO2017006139 
Protection Patent application published
Year Protection Granted 2017
Licensed Commercial In Confidence
Impact Discussions taking place with industrial collaborator around formation of spin out company. Enterprise Fellowship awarded.