China kadoorie biobank - University of Oxford
Lead Research Organisation:
University of Oxford
Department Name: UNLISTED
Abstract
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Technical Summary
China has undergone a rapid transition in disease patterns, with chronic non-communicable diseases such as stroke, ischaemic heart disease (IHD), cancer and emphysema (COPD) accounting for most of the remaining mortality and disability. For these diseases, there are still large unexplained variations in the age specific rates between different countries and between different regions in China, indicating that important causes remain to be discovered. Heterogeneity in disease rates, non-genetic risk factors and genetic architecture, between Chinese and Western populations, and between different parts of China, helps identify new risk factors and explore known causes more comprehensively. This is particularly true for stroke, which is much less well understood in terms of genetic and non-genetic determinants than IHD.2,5,6 Stroke can be investigated particularly effectively in China, as disease rates are high and widespread use of CT/MRI allows reliable determination of stroke subtypes. Better understanding of the genetic and environmental causes of disease can lead to improvements in disease prevention, risk prediction and development of new therapies. Although retrospective case-control studies suffice for studying purely genetic factors, large bloodbased prospective studies are required for studying many non-genetic causes, and many interactions.
Genome-wide association studies (GWAS) in Caucasian have identified many disease correlates. However, some loci extend over hundreds of kilobases, involving several genes and many variants that are indistinguishable because of linkage disequilibrium (LD). Comparisons of GWAS data from the Chinese and Caucasian populations will provide opportunities to exploit local LD structure in different ethnic groups, leading to finer mapping of these known loci.
To maximise the potential of the CKB as a comprehensive and unique biomedical research resource, we wish to undertake cohort-wide genotyping, using a custom-designed 700K SNP array (Affymetrix) optimised for Chinese populations. Newton Fund support would be used exclusively for genotyping and imputation, and will allow up to 100,000 participants to be genotyped within two years. To complete genotyping of the entire CKB cohort of 0.5 million participants, additional funding will be sought from other sources in the UK and elsewhere. Because extensive baseline information and follow-up information already exists, and planned multi-omics assays of the stored biological samples is likely to be funded from other sources, information from the proposed genotyping would create a uniquely powerful and rich resource for biomedical research over the next decade or more.
Genome-wide association studies (GWAS) in Caucasian have identified many disease correlates. However, some loci extend over hundreds of kilobases, involving several genes and many variants that are indistinguishable because of linkage disequilibrium (LD). Comparisons of GWAS data from the Chinese and Caucasian populations will provide opportunities to exploit local LD structure in different ethnic groups, leading to finer mapping of these known loci.
To maximise the potential of the CKB as a comprehensive and unique biomedical research resource, we wish to undertake cohort-wide genotyping, using a custom-designed 700K SNP array (Affymetrix) optimised for Chinese populations. Newton Fund support would be used exclusively for genotyping and imputation, and will allow up to 100,000 participants to be genotyped within two years. To complete genotyping of the entire CKB cohort of 0.5 million participants, additional funding will be sought from other sources in the UK and elsewhere. Because extensive baseline information and follow-up information already exists, and planned multi-omics assays of the stored biological samples is likely to be funded from other sources, information from the proposed genotyping would create a uniquely powerful and rich resource for biomedical research over the next decade or more.
Organisations
- University of Oxford (Lead Research Organisation)
- Olink AB (Collaboration)
- University of Colorado Boulder (Collaboration)
- Nanjing Medical University (Collaboration)
- Novo Nordisk (Collaboration)
- Massachusetts General Hospital (Collaboration)
- Broad Institute (Collaboration)
- Nightingale Health Ltd. (Collaboration)
- ReproGen Consortium (Collaboration)
- Global Lipids Genetic Consortium (GLGC) (Collaboration)
- University of Bristol (Collaboration)
- University College London (Collaboration)
- UNIVERSITY OF LEICESTER (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- McGill University (Collaboration)
- Social Science Genetics Association Consortium (Collaboration)
- University of Kuopio (Collaboration)
- University of North Carolina at Chapel Hill (Collaboration)
- Peking University (Collaboration)
- Beijing Genomics Institute (Collaboration)
- University of Oulu (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Bayer (Collaboration)
- SomaLogic (Collaboration)
People |
ORCID iD |
Zhengming Chen (Principal Investigator) |
Publications
Yang S
(2023)
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
in Stroke and Vascular Neurology
Poorthuis MHF
(2022)
Risks of Stroke and Heart Disease Following Hysterectomy and Oophorectomy in Chinese Premenopausal Women.
in Stroke
Karim MA
(2020)
Systemic inflammation is associated with incident stroke and heart disease in East Asians.
in Scientific reports
Hamilton E
(2022)
Conventional and genetic risk factors for chronic Hepatitis B virus infection in a community-based study of 0.5 million Chinese adults
in Scientific Reports
Bovijn J
(2021)
Response to comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics".
in Science translational medicine
Bovijn J
(2020)
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
in Science Translational Medicine
Wang X
(2023)
Life-course adiposity and severe liver disease: a Mendelian randomization analysis
in Obesity
Wang W
(2021)
Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses.
in Nutrition, metabolism, and cardiovascular diseases : NMCD
Yu C
(2023)
A high-resolution haplotype-resolved Reference panel constructed from the China Kadoorie Biobank Study
in Nucleic Acids Research
Jaworek T
(2022)
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke.
in Neurology
Im PK
(2023)
Alcohol consumption and risks of more than 200 diseases in Chinese men.
in Nature medicine
Sun L
(2019)
Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults.
in Nature medicine
Shrine N
(2019)
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
in Nature genetics
Bakker MK
(2020)
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
in Nature genetics
Howe L
(2022)
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
in Nature Genetics
Mahajan A
(2022)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
in Nature genetics
Ding C
(2023)
Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.
in Nature communications
Laisk T
(2020)
The genetic architecture of sporadic and multiple consecutive miscarriage.
in Nature communications
Description | There is a considerable and well-recognised gap in health genetics research whereby European populations are greatly over-represented by comparison with other ancestries. This award supported the genotyping of 100k China Kadoorie Biobank participants. To date 10K participants samples have also undergone whole genome sequencing and a further expansion of this is planned for 2024. Thanks to this award, CKB is now a major - and growing - resource in combating the gap in genomic and other health-focused research as it impacts populations of East Asian ancestry worldwide. This award has had many notable findings as can be observed in the large number of paper that have been published using the data generated. The award has resulted in collaborations with 100+ global genomics consortia and research partners as well as stand alone papers on the China Kadoorie Biobank. Research insights are helping to improve health equity for persons with Chinese heritage across Asia, Africa and the US, as well as globally. |
Exploitation Route | The resulting dataset will continue to be a productive and highly valuable global resource for years to come. |
Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
Description | BHF Centre for Research Excellence |
Amount | £198,595 (GBP) |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2016 |
End | 10/2018 |
Title | China Kadoorie Biobank - Research Database |
Description | China Kadoorie Biobank (CKB) is a blood-based prospective cohort study of 512,000 adults, recruited from 10 diverse areas across China (during 2004-08), with extensive data collection at baseline and subsequent resurveys and long-term storage of biological samples. These exposure and outcome data are complemented by separately funded genotyping (currently for 102,000 participants), whole genome sequencing, and conventional and multi-omics assays for nested case-control studies of specific diseases. |
Type Of Material | Database/Collection of data |
Year Produced | 2015 |
Provided To Others? | Yes |
Impact | Group staff and collaborating institution have published over 400 papers using the CKB database. Since opening CKB data up for open access in September 2015, over 800 researchers have registered on the CKB Data Access System. By February 2023 over 200 datasets had been approved and delivers to external collaborators and open access researchers. |
URL | https://www.ckbiobank.org/site/Data+Access |
Description | BDI |
Organisation | University of Oxford |
Department | Big Data Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analyses of CKB data conducted according to group protocols and summary results supplied. |
Collaborator Contribution | Development of Anlaysis protocol for GWAS for miscarriage. |
Impact | GWAS of miscarriage traits complete, results supplied, published in Nature Communications 2020, PMID: 33239672 |
Start Year | 2017 |
Description | Bayer - CKB Collaborative Research Programme |
Organisation | Bayer |
Country | Germany |
Sector | Private |
PI Contribution | Joint initiative to: Investigation of chymase gene variants in CKB; reformat plasma samples for future multiomics assays ; conduct analyses of pilot proteomics data; perform quality control and characterisation of ~80,000 putative loss-of-function, missense, or other functionally-significant variants; develop phenome-wide and bioinformatics analyses pipelines for future work. |
Collaborator Contribution | Selection of variants of interest w.r.t drug targets; review of ongoing progress; |
Impact | Initial results for Chymase investigation in CKB; selection of CKB samples for reformatting from freezer storage initiated. |
Start Year | 2019 |
Description | Beijing Genomics Institute |
Organisation | Beijing Genomics Institute |
Country | China |
Sector | Academic/University |
PI Contribution | In kind contributions to assay costs for various DNA projects. CKB are working with BGI on various research projects including DNA extraction and large-scale GWAS of 100,000 CKB samples. We are also collaborating with BGI's Research organisation on a Mitochondrial DNA Project. This Project involves a pilot project of high-coverage sequencing of the mitochondrial genomes of up to 100 parent-offspring trios (300 samples) from the China Kadoorie Biobank, followed by the main project of sequencing of 15,000 additional samples. These results can be used to assess the inheritance patterns of mitochondrial genomes, including the extent of heteroplasmy and paternal inheritance. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and are awaiting signature. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and being finalised |
Collaborator Contribution | BGI are providing the facilities and technical infrastructure for the conduct of genomic assays including data handling and shared analysis |
Impact | Large scale GWAS of 100,000 CKB samples complete data available for analysis. Lookup of GWAS association for ~1900 SNPs provided. Manuscript published in Cell for BMI and height GWAS Whole Genome Sequencing of 10,000k CKB Sample underway. |
Start Year | 2015 |
Description | Broad Institute |
Organisation | Broad Institute |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Sitting/standing height ratio GWAS |
Collaborator Contribution | Sitting/standing height ratio GWAS |
Impact | Analysis plan complete. Summary statistics for 4 traits, 100k individuals supplied, initial analyses complete. Supplementary analyses in progress |
Start Year | 2018 |
Description | CARDIOGRAMplusC4D |
Organisation | University of Oxford |
Department | Medical Sciences Division |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of GWAS Summary Statistics |
Collaborator Contribution | GWAS of myocardial infarction |
Impact | Data Shared Analysis in progress. |
Start Year | 2021 |
Description | Cambridge Cardiology |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Metaanalysis of NMR metabolomics GWAS |
Collaborator Contribution | Metaanalysis of NMR metabolomics GWAS |
Impact | NMR metabolomics GWAS complete, data supplied |
Start Year | 2019 |
Description | GIANT: Genetic Investigation of ANthropometric Traits |
Organisation | Broad Institute |
Department | The Genetic Investigation of ANthropometric Traits (GIANT) |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS Data for ~28k subjects supplied to assist various meta analyses being conducted by this group. CKB involved in convening the trans-ethnic analysis sub-group. |
Collaborator Contribution | Large meta-analysis of Height, BMI, WHR, WHRadjBMI; Joint / consortium publications |
Impact | papers under preparation |
Start Year | 2017 |
Description | GLGC |
Organisation | Global Lipids Genetic Consortium (GLGC) |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | GWAS Data for ~18k subjects supplied to assist various meta analyses being conducted by this group. |
Collaborator Contribution | Large meta-analysis of TC, LDL-c, HDL-c, TG |
Impact | Metaanalysis complete, first manuscript to be submitted soon |
Start Year | 2017 |
Description | GWAS & Sequencing Consortium of Alcohol and Nicotine |
Organisation | University of Colorado |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS of smoking, alcohol, U Colorado, for the GENESCAN consortium |
Collaborator Contribution | GWAS results supplied. Metanalysis ongoing |
Impact | Summary statistics supplied, paper in preparation |
Start Year | 2018 |
Description | International Stroke Genetics Consortium |
Organisation | Massachusetts General Hospital |
Department | International Stroke Genetics Consortium |
Country | United States |
Sector | Hospitals |
PI Contribution | CKB plans to share genomics data or contribute to GWAS meta-analyses being conducted by this group. Summary statistics have been shared for GWAS of: (i) sub-arachnoid haemorrhage/ unruptured intracranial aneurysm; (ii) incident all stroke; (iii) fatal stroke, and mortality of incident stroke. Results of other analyses will only be shared after publication of CKB specific stroke genetics paper. |
Collaborator Contribution | Long-term collaboration. Access to additional GWAS data to increase the likelihood of novel significant findings. |
Impact | In Progress |
Start Year | 2016 |
Description | Investigation of proteomics in the China Kadoorie Biobank. |
Organisation | Novo Nordisk |
Country | Denmark |
Sector | Private |
PI Contribution | 1) To generate proteomic data covering 384 proteins, using the OLINK Explore 384 Cardiometabolic assay, in 2000 MI cases and 2000 population-based controls; 2) To investigate the genetic architecture of a panel of 384 proteins through GWAS.; 2) To undertake PheWAS of particular genetic variants for specific proteins with lifestyle factors, quantitative traits and disease outcomes. |
Collaborator Contribution | Contributions to funding for the project and provision of technical support and advice to CKB regarding any drug targets under investigation. and input on the statistical analysis plan and support for the GWAS of the proteins |
Impact | Proteomics data generated using the Olink Explore 1536 Platform |
Start Year | 2021 |
Description | McGill University |
Organisation | McGill University |
Department | Genetic Epidemiology Richards Lab |
Country | Canada |
Sector | Academic/University |
PI Contribution | Validation of genetic risk score for bone mineral density |
Collaborator Contribution | List of variants and weights supplied. |
Impact | Association results from up to 102K individuals for a BMD risk score with BMD and endpoints, published in Genome Medicine 2021, PMID: 33536041 |
Start Year | 2018 |
Description | Nanjing Medical University |
Organisation | Nanjing Medical University |
Country | China |
Sector | Academic/University |
PI Contribution | Access to data resulting from genotyping. |
Collaborator Contribution | Contributing research and analystical expertise. CKB/ Oxford hosted a post-doctoral researcher from Nanjing who is continuing to work on this project since his return. |
Impact | Papers currently being drafted. |
Start Year | 2015 |
Description | Nightingale Health, Finland |
Organisation | Nightingale Health Ltd. |
Country | Finland |
Sector | Private |
PI Contribution | Metaanalysis of SNPs and gene-specific GRSs with lipid/NMR data. Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples. |
Collaborator Contribution | academic partnership |
Impact | Paper published in Circulation |
Start Year | 2018 |
Description | Novo Nordisk - Oxford : Fellowship |
Organisation | University of Oxford |
Department | Novo Nordisk – Oxford Fellowship Programme |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Support for a 3-year post doctoral fellowship investigating "Genomic approaches to improve understanding of T2D molecular phenotypes, mechanisms, and development of major complications in diverse populations" CKB team will be providing access to CKB data and expert supervision and guidance. |
Collaborator Contribution | Novo Nordiask Fellowship scheme will provide financial support alongside expert supervision and training from their research and development teams. |
Impact | None to date ( early stages) |
Start Year | 2022 |
Description | OLINK Proteomics Expansion Analysis |
Organisation | Olink AB |
Country | Sweden |
Sector | Private |
PI Contribution | Provision of CKB samples for analysis and permission to agreed usage of a subset of the resulting data and additional pre-existing CKB study data (Questionnaire, Physical Measurement and Olink data). CKB will use the resulting data to investigate the associations of novel proteomic markers with risk of IHD (and other diseases) and to identify novel biomarkers for risk prediction and potentially modifiable targets for treatment and prevention of IHD; |
Collaborator Contribution | The multiplex biomarker panel, Olink® EXPLORE Expansion Analysis (1536), is to be used to measure 1472 high-quality assays for proteins important for inflammation or related biological processes.. OLINK agreed to provide these services free of charge contingent on the agreed usage of a subset of the resulting data and additional pre-existing CKB study data (Questionnaire, Physical Measurement and Olink data). |
Impact | Data has been delivered to CKB and initial publication have been drafted for submission to peer reviewed journals. |
Start Year | 2022 |
Description | Peking University PKU |
Organisation | Peking University |
Country | China |
Sector | Academic/University |
PI Contribution | Replication of fingerprint GWAS. Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided. Results of GWAS provided for metaanalysis. |
Collaborator Contribution | academic partnership |
Impact | Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided, full GWAS provided for metaanalysis, paper in preparation |
Start Year | 2018 |
Description | Pilot study for evaluation of polygenic risk scores in Chinese adults |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | University of Oxford parties will implement the analyses in CKB and assess the associations of six PGS scores with six CVD risk factors and six disease outcomes. The analyses will also assess the discrimination and calibration of the PGS scores for each trait. At least for total CVD, total stroke and total IHD, the analyses will compare discrimination and calibration of established non-genetic scores with PGS scores |
Collaborator Contribution | Cambridge will provide to Oxford parties PGS scores for six CVD risk factors and six CVD outcomes with appropriate instructions to complete the scores for the six continuous and six dichotomous traits in CKB. Tasks: • To provide genetic instruments for six quantitative traits in CKB and instructions ion their use • To provide Genetic instruments for six disease outcomes in CKB and instructions ion their use |
Impact | Initial datasets shared |
Start Year | 2022 |
Description | Reprogen |
Organisation | ReproGen Consortium |
Country | Global |
Sector | Academic/University |
PI Contribution | Conducting GWAS of reproductive traits. |
Collaborator Contribution | GWAS analyses complete. Currently doing lookup of existing (known) hits, and various heritability analyses. In discussion about future joint analyses/papers |
Impact | Association results from 31177 individuals for 247 variants supplied, revised manuscript submitted to Nature |
Start Year | 2017 |
Description | Social Science Genetics Association Consortium |
Organisation | Social Science Genetics Association Consortium |
Country | Global |
Sector | Charity/Non Profit |
PI Contribution | GWAS of socioeconomic traits, USC, USA, for the SSGAC consortium |
Collaborator Contribution | GWAS results supplied for ~10 different traits. |
Impact | ~12 sets of summary stats supplied. Manuscript to be submitted soon |
Start Year | 2018 |
Description | Somalogic Proteomics |
Organisation | SomaLogic |
Country | United States |
Sector | Private |
PI Contribution | Access to CKB samples to SomaLogic's SOMAscan® Assay. Evaluation of the performance of the following SomaSignal tests (SSTs) for prediction of cardiovascular risk; ii. Evaluate the SSTs for metabolic health compared to relevant clinical measures in the CKB. Investigate proteomic associations with CV risk and cardiometabolic health in the Chinese population. Evaluate the performance of SomaLogic Data compared to data generated using a differing proteomic platform in the Samples |
Collaborator Contribution | SomaLogic will evaluate the Samples using its SOMAscan Assay (including the Restricted SOMAmer Content) utilizing reagents and protocols developed and standardized by SomaLogic. SomaLogic will advise Oxford on issues related to data processing, normalization, transformation, and QC check; Somalogic and Oxford will will collaborate on submission of the Research Results to a peer-reviewed publication and plan follow-on studies and/or additional analyses |
Impact | Data has been generated by Somalogic and delivered to Oxford for analysis. |
Start Year | 2022 |
Description | Spirometer/BiLEVE |
Organisation | University of Leicester |
Department | Department of Health Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analysis in CKB of associations between spirometry measures/COPD and genetic loci identified by the Leicester group. |
Collaborator Contribution | Ongoing long-term collaboration. |
Impact | Two papers published in Nature Genetics "Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets", "New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries" |
Start Year | 2015 |
Description | UCL - Lipid traits - KK |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Signals of natural selection for lipid traits |
Collaborator Contribution | Signals of natural selection for lipid traits |
Impact | Summary stats provided, data access provided to KK as visiting researcher, paper published in Nature Communications 2019, PMID: 31551420 |
Start Year | 2019 |
Description | UCL - Lipid traits - KK |
Organisation | University College London |
Department | Division of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Signals of natural selection for lipid traits |
Collaborator Contribution | Signals of natural selection for lipid traits |
Impact | Summary stats provided, data access provided to KK as visiting researcher, paper published in Nature Communications 2019, PMID: 31551420 |
Start Year | 2019 |
Description | UNC School of Medicine - Psychiatric Genomes Consortium |
Organisation | University of North Carolina at Chapel Hill |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS of various psychiatric and related traits, |
Collaborator Contribution | Analysis plan received for GWAS of Major Depression and for Depressive Symptoms. GWAS completed, summary statistics supplied. |
Impact | Summary stats supplied, manuscript submitted to Nature Genetics, data access provided for supplementary analyses to KK as visitiing researcher from UCL under the Psychiatric Genomes Consortium |
Start Year | 2018 |
Description | University of Bristol |
Organisation | University of Bristol |
Department | MRC Integrative Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Three projects: 1) GWAS of alcohol-related flushing and flushing 2) Within families GWAS of multiple traits 3) Mendelian randomisation of education |
Collaborator Contribution | Visiting researcher from Bristol working within CKB. |
Impact | Access to data for all three projects provided to visiting researcher. Analysese ongoing, Within families GWAS analyses completed for priority traits, manuscript submitted to Nature Genetics |
Start Year | 2018 |
Description | University of Cambridge - Dept of Medicine |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of controls data (300 CKB samples) for GWAS of ANCA vasculitis being conducted by Cambridge. |
Collaborator Contribution | The genotype data suppliedto Oxford is being used to compare the performance of the China Kadoorie Biobank and UK BioBank arrays in ethnically distinct cohorts. |
Impact | Joint research papers. |
Start Year | 2016 |
Description | University of Nottingham Malaysia/Cancer Research Malaysia |
Organisation | University of Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of Risk score association results for Meta analysis |
Collaborator Contribution | Leadership of project and aggregations of other data sources |
Impact | Association results provided for 4 risk scores. Manuscript submitted to Nature Communications |
Start Year | 2020 |
Description | University of Oulu |
Organisation | University of Oulu |
Country | Finland |
Sector | Academic/University |
PI Contribution | Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples |
Collaborator Contribution | Meta-analysis of SNPs and gene-specific GRSs with lipid/NMR data. Also providing expertise on MNR metabolomics platform and analysis of CKB samples (stroke case-control study and Pancreatic cancer case-control study). |
Impact | paper published in Circulation: Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment |
Start Year | 2017 |
Description | University of Oxford - OCDEM |
Organisation | University of Oxford |
Department | Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Access to relevant CKB data including genomics data and diabetes outcome data. Paper drafting and internal genomics expertise and supervision. |
Collaborator Contribution | Provision of a post graduate research assistant working on the the identification and characterization of genetic variants that influence predisposition to type 2 diabetes and related traits. |
Impact | Contributed several novel and interesting findings including published research papers |
Start Year | 2014 |
Description | Urine NMR Metabolomics |
Organisation | University of Kuopio |
Country | Finland |
Sector | Academic/University |
PI Contribution | Provision of 25,000 CKB Urine samples and associated participant data for quantification of metabolites, |
Collaborator Contribution | Kuopio will employ a NMR-spectroscopy protocol that has been developed, optimized and validated by them to measure up to 50 biomarkers in all ~25,000 samples. Kuopio will quantify metabolite peaks and generate metabolite concentrations. Data will be available in absolute concentrations (?mol/L), as well as referenced to creatinine concentration. Data resultsin all ~25,000 samples will be shared with Oxford. As additional information for other metabolites becomes available using the NMR spectra, these will be provided to Oxford. |
Impact | Samples shipped, analyses being conducted |
Start Year | 2020 |
Description | Wellcome Trust Centre for Human Genetics |
Organisation | University of Oxford |
Department | Wellcome Trust Centre for Human Genetics |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Access to data resulting from genotyping. |
Collaborator Contribution | Collaborated in the design of a customised genotyping array for genome-wide analysis, which is complementary to the UK Biobank array, and will facilitate future joint projects in the genomics of common diseases. |
Impact | Groups at the WTCHG work closely with the CKB team in genome wide data imputation and analysis, for work on stroke, as well as the partial cohort-wide genotyping funded by the MRC-Newton fund. |
Start Year | 2015 |
Description | Alcohol Phewas paper engagement |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Becky Im responded to queries from press on the Nat Med 2023 CKB alcohol PheWAS paper (Fox News in June 2023; Norway's newspaper VG in September 2023); She also co-wrote (with Iona Millwood) a blog with Iona Millwood on the CKB alcohol PheWAS paper on the Institute of Alcohol Studies website (June 2023). |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ias.org.uk/2023/06/13/unveiling-the-hidden-health-hazards-of-alcohol-use/ |
Description | Alcohol and CVD paper engangement activities |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Media coverage of publication of alcohol and CVD, including BBC TV and radio interviews, and a press conference for national newspapers, April 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | BBC World Service = Science In Action |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview on the BBC World Service programme Science in Action - Professor Zhengming Chen explained how the seed of an idea grew into one of the world's largest prospective studies. "In 2004, about a year after the first human genome was sequenced, the China Kadoorie Biobank received funding to start collecting blood samples from over half a million people in ten regions of China. Samples were put into long-term storage and now, nearly 20 years later, the technology is available to analyse tiny samples of blood for thousands of proteins and metabolites. The millions of stored blood samples are bar-coded and linked to other data collected from the study participants including genetic data and information on lifestyle factors and health conditions. Professor Chen and colleagues from the NDPH Wolfson Laboratories described how this unique resource provides opportunities for endless research. Professor Chen predicted that over the next five to ten years the CKB will generate a huge amount of information that will enable a better understanding of the prevention and treatment of many diseases." (starts:11.40 ends:18.53) |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.bbc.co.uk/programmes/w3ct369l |
Description | Coverage on study in Pharmaceutical industry trade journal |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Some coverage of paper on LPa2 emphasising the implications for drug target discovery and pharmaceutical inductrial practice. https://www.drugtargetreview.com/news/12376/prospective-biobank-studies/ |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.drugtargetreview.com/news/12376/prospective-biobank-studies/ |
Description | Human Proteome and Public Health Symposium (Researchers and Industry Partners) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 200+ people attended this one-day symposium which brought together academic researchers, biobank managers and a range of proteomics industry partners to discuss emerging analysis results and assay platforms developments. The event helped |
Year(s) Of Engagement Activity | 2023 |
Description | Research paper press releases x 7 Covering Tobacco Control; Alcohol Consumption and Disease Risk; Blood Proteins and Heart Disease Drug Targets; Folic Acid and Stroke; Blood Proteins and Obesity Treatment Targets; Genotyping and Populations Characteristics in CKB |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Seven separate press releases prepared and circulated via central Oxford Press office, Journal Press Offices , OxPop and CKB Websites during 2023 covering a range of topics to accompany major publication outputs |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ckbiobank.org/news-1 |
Description | UK Parliament POST note on "Diet, nutrition and cancer " |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Contribution to the recent UK Parliament POSTnote on "Diet, nutrition and cancer" offering views and evidence on alcohol and cancer via an interview (20th Feb 2024). This work aims to summarise the existing evidence, research methods, public health trends and interventions surrounding diet nutrition and cancer. |
Year(s) Of Engagement Activity | 2024 |
URL | https://post.parliament.uk/approved-work-diet-nutrition-and-cancer/ |