Integrative genomic, epigenetic and functional studies in diabetic kidney disease
Lead Research Organisation:
Queen's University Belfast
Department Name: UNLISTED
Abstract
Kidney disease is a common and devastating complication of diabetes, and represents a major public health problem worldwide. The inherited, genetic factors that play a role in determining who will get this complication are beginning to be discovered, creating opportunities to understand the underlying biological basis of diabetic kidney disease, which will guide the development of improved treatments and preventive measures. We will combine and integrate data from several complementary approaches (genetics, epigenetics, gene expression analysis and studies in model systems) to identify genes and biological processes that influence the development of diabetic kidney disease.
Technical Summary
Diabetic kidney disease (DKD) is a leading cause of kidney failure and end stage renal disease, and brings a substantial burden of early mortality and accompanying health care costs. Genetic factors contribute to the risk of DKD. If we could identify these genetic factors, we could better understand the mechanisms by which DKD occurs, and thereby accelerate the development of better therapies. We established the GENIE consortium, a collaboration between Queen's University Belfast, University of Dublin, University of Helsinki, and the Broad Institute. Together, we completed the largest genetic study to date of DKD, and successfully identified the first two robust genetic risk factors for DKD. In a separately funded genetic study, we are collaborating with additional groups to extend our efforts and encompass larger samples. To better understand the underlying biology and pathophysiology of DKD, we propose to complement and build on our past and ongoing genetic studies in several critical ways. We will leverage a co-funding mechanism between Ireland, Northern Ireland and the US to carry out a multidisciplinary investigation of DKD. We will assemble and jointly analyze all available genetic data pertinent to DKD, to begin the process of discovering rarer variants with stronger effects on DKD. We will also generate DNA methylation data in kidney and blood, and in patients with and without DKD, and also expression data in samples relevant to DKD. We use a novel and powerful method to integrate the genetic, epigenetic and genomic data to generate hypotheses about the biological causes of DKD, and test these hypotheses with further genetic studies (sequencing in a large follow-up sample) and with functional studies in models of DKD. This international, multidisciplinary collaboration will build on genetic discoveries to help decipher the underlying biology and pathophysiology of DKD and thereby guide the prevention and treatment of this important disease.
Organisations
- Queen's University Belfast (Lead Research Organisation)
- Public Health Agency (PHA) (Collaboration)
- Wellcome Trust (Collaboration)
- Department for Employment and Learning (DEL) (Collaboration)
- University of Galway (Collaboration)
- Science Foundation Ireland (SFI) (Collaboration)
- Health Research Board (HRB) (Collaboration)
People |
ORCID iD |
A Maxwell (Principal Investigator) |
Publications
Anderson K
(2019)
The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.
in Frontiers in genetics
Bailie C
(2017)
Development of next generation sequencing panel for UMOD and association with kidney disease.
in PloS one
Benson KA
(2017)
Design and implementation of a custom next generation sequencing panel for selected vitamin D associated genes.
in BMC research notes
Browne D
(2019)
Serum xanthophyll carotenoids are associated with estimated glomerular filtration rate in an aged cohort.
in Scientific reports
Cappa R
(2020)
"Mitochondrial Toolbox" - A Review of Online Resources to Explore Mitochondrial Genomics.
in Frontiers in genetics
Cañadas-Garre M
(2019)
Proteomic and metabolomic approaches in the search for biomarkers in chronic kidney disease.
in Journal of proteomics
Cañadas-Garre M
(2018)
Genomic approaches in the search for molecular biomarkers in chronic kidney disease.
in Journal of translational medicine
Cañadas-Garre M
(2019)
Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.
in Frontiers in genetics
Title | STEAMing Kidneys - Where Science and Art Collide |
Description | An event, as part of the Northern Ireland Science Festival, in the Accidental Theatre, Belfast that celebrates science, technology, art and music related to kidney disease. |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2023 |
Impact | Brief science updates from PhD students and postdocs. Presentations from nursing academics and administrator for the Renal Arts Group Overview of three kidney charities (NIKPA, NIKRF and Kidney Care UK) from local representatives of these organisations. Music from Ragbone, a rhythm and blues band. A collaboration between the Renal Arts Group, scientists, clinicians and local charities |
URL | https://nisciencefestival.com/events/steaming-kidneys-where-science-and-art-collide |
Title | The Art Health and Wellbeing (an evening of art, performance and discussion with patients, clinicians and academics) |
Description | ESRC Festival of Social Science at Sunflower Bar, Belfast, 6th November 2019 (an evening of art, performance and discussion with patients, clinicians and academics) |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2019 |
Impact | Renal Arts Group is now established as a collaboration between patients, carers, clinicians, academics and artists to develop a programme of research with the ultimate aim of improving the physical and psychological quality of life of those living with kidney disease |
URL | https://www.facebook.com/renalartsgroupqub/ |
Title | The future of kidney research is STEAM powered |
Description | An event in the Crescents Art Centre as part of the Northern Ireland Science Festival. A collaboration between university researchers, kidney patient charities (NIKPA and NIKRF), Renal Arts Group and local musicians. A showcase for current research and the interface between STEM subjects and the Arts https://www.qub.ac.uk/sites/renal-arts-group/ |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2022 |
Impact | An interactive event leading to cross disciplinary working and better partnership with patient organisations |
URL | https://www.qub.ac.uk/sites/renal-arts-group/ |
Description | Guidelines for the Treatment of Hyperkalaemia in Hospitalised Adults |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Participation in a guidance/advisory committee |
Impact | The new guidelines for hyperkalaemia have been adopted by all healthcare trusts and are integrated into undergraduate curricula and postgraduate training. |
URL | https://www.rqia.org.uk/RQIA/files/e7/e7a80cc0-f8d5-4344-a210-350de196a8bd.pdf#:~:text=10-,Is%20urge... |
Description | A multi-centre, multidimensional approach to New Onset Diabetes After Transplantation (NODAT) |
Amount | £164,383 (GBP) |
Funding ID | KS_RP_007_20190919 |
Organisation | Kidney Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2020 |
End | 05/2022 |
Description | Aldosterone bloCkade for Health ImproVement Evaluation in end-stage renal disease - a randomised double blind placebo-controlled trial in the United Kingdom (ACHIEVE-UK) |
Amount | £650,557 (GBP) |
Funding ID | C S/20/2/34731 |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2024 |
Description | European Union Horizon 2020 |
Amount | € 5,900,000 (EUR) |
Organisation | European Union |
Sector | Public |
Country | European Union (EU) |
Start | 07/2015 |
End | 07/2020 |
Description | Irish Clinical Academic Training programme |
Amount | £12,000,000 (GBP) |
Funding ID | EAT/5304/16 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2018 |
End | 07/2025 |
Description | Northern Ireland Kidney Research Fund - Clinical Research Fellowship |
Amount | £149,000 (GBP) |
Organisation | Northern Ireland Kidney Research Fund |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2017 |
End | 07/2019 |
Title | Northern Ireland Kidney Transplant Research Database |
Description | Prospectively collected data on renal transplantation since 1968 with clinical information on >2800 kidney transplants. IRAS Project ID: 239344 This database received favourable REC opinion in 2013 and was renewed as a research database in 2018 and again in 2023. |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | Integration of anonymised clinical and genomic data from this research database has been used in meta-analyses of kidney transplant outcomes. Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study. Hernandez-Fuentes MP, Franklin C, Rebollo-Mesa I, Mollon J, Delaney F, Perucha E, Stapleton C, Borrows R, Byrne C, Cavalleri G, Clarke B, Clatworthy M, Feehally J, Fuggle S, Gagliano SA, Griffin S, Hammad A, Higgins R, Jardine A, Keogan M, Leach T, MacPhee I, Mark PB, Marsh J, Maxwell P, McKane W, McLean A, Newstead C, Augustine T, Phelan P, Powis S, Rowe P, Sheerin N, Solomon E, Stephens H, Thuraisingham R, Trembath R, Topham P, Vaughan R, Sacks SH, Conlon P, Opelz G, Soranzo N, Weale ME, Lord GM; United Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3. Am J Transplant. 2018 Jun;18(6):1370-1379. doi: 10.1111/ajt.14594. Epub 2018 Feb 1. PMID: 29392897 Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort. Stapleton CP, Birdwell KA, McKnight AJ, Maxwell AP, Mark PB, Sanders ML, Chapman FA, van Setten J, Phelan PJ, Kennedy C, Jardine A, Traynor JP, Keating B, Conlon PJ, Cavalleri GL. Am J Transplant. 2018 Aug 7. doi: 10.1111/ajt.15057. [Epub ahead of print] PMID: 30085400 |
Description | Discovery of an integrated risk profile for chronic kidney disease and development of a clinical biomarker panel for personalising medicine (Stratified medicine for chronic kidney disease) |
Organisation | Department for Employment and Learning (DEL) |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | This application was founded on the original data obtained from research grants supported by the US Ireland R&D Partnership. There has been a long term strategic collaboration between Prof Catherine Godson (UCD) and my research group at QUB. This collaboration supported by the US Ireland R&D Partnership has been fundamental in generating new genomic data for diabetic kidney disease and more generally for chronic kidney disease. This data was integral to the successful application to the SFI-DfE partnership scheme. |
Collaborator Contribution | We have used a combination of genome-wide association studies and epigenome-wide association studies to generate data for up to 20,000 individuals with kidney disease. These data were coupled with original in vitro observations in diabetic kidney disease models developed by our colleagues in UCD. This integrated data was used to secure the 5 year programme grant (SFI-DfE RoI-NI funding) |
Impact | Grant started in August 2016 with recruitment of post-doctoral research fellow in January 2017 and postgraduate research student (commencing September 2017) |
Start Year | 2016 |
Description | Discovery of an integrated risk profile for chronic kidney disease and development of a clinical biomarker panel for personalising medicine (Stratified medicine for chronic kidney disease) |
Organisation | Science Foundation Ireland (SFI) |
Country | Ireland |
Sector | Charity/Non Profit |
PI Contribution | This application was founded on the original data obtained from research grants supported by the US Ireland R&D Partnership. There has been a long term strategic collaboration between Prof Catherine Godson (UCD) and my research group at QUB. This collaboration supported by the US Ireland R&D Partnership has been fundamental in generating new genomic data for diabetic kidney disease and more generally for chronic kidney disease. This data was integral to the successful application to the SFI-DfE partnership scheme. |
Collaborator Contribution | We have used a combination of genome-wide association studies and epigenome-wide association studies to generate data for up to 20,000 individuals with kidney disease. These data were coupled with original in vitro observations in diabetic kidney disease models developed by our colleagues in UCD. This integrated data was used to secure the 5 year programme grant (SFI-DfE RoI-NI funding) |
Impact | Grant started in August 2016 with recruitment of post-doctoral research fellow in January 2017 and postgraduate research student (commencing September 2017) |
Start Year | 2016 |
Description | NOVEL STROMAL CELL THERAPY FOR DIABETIC KIDNEY DISEASE (NEPHSTROM Study) |
Organisation | University of Galway |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Clinical trial of mesenchymal stem cells for diabetic kidney disease Primary Objective The primary objective of this trial is to establish the safety and tolerability of a single intravenous infusion of NEPHSTROM ORBCEL-M in study participants with T2D and progressive DKD. Secondary Objective The secondary objectives of this study are to evaluate the potential efficacy of an intravenous infusion of NEPHSTROM ORBCEL-M to halt or slow the progression of DKD and to acquire mechanistic data regarding the anti-inflammatory and immune-modulatory activity of NEPHSTROM ORBCEL-M in these study participants. Belfast City Hospital is a clinical trial recruitment site and the laboratory site for anti-HLA testing |
Collaborator Contribution | This is a Horizon2020 EU grant lead by National University of Ireland, Galway and in partnership with Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Nephrology and Dialysis Unit Piazza OMS, 1 - Bergamo, Italy Clinical Research Centre for Rare Diseases Aldo e Cele Daccò IRCCS-Istituto di Ricerche Farmacologiche Mario Negri Via G.B. Camozzi, 3 - 24020 Ranica, Bergamo, Italy Principal Investigator: Prof. Giuseppe Remuzzi Clinical Trial Coordinating Centre Belfast Health and Social Care Trust Belfast City Hospital Belfast, UK Principal Investigator: Prof. Peter Maxwell University Hospital Birmingham NHS Foundation Trust Queen Elizabeth Medical Centre Birmingham, UK Principal Investigator: Prof. Paul Cockwell National University of Ireland & Galway University Hospital Galway, Ireland Principal Investigator: Prof. Matthew Griffin |
Impact | Chronic kidney disease, health-related quality of life and their associated economic burden among a nationally representative sample of community dwelling adults in England. Nguyen NTQ, Cockwell P, Maxwell AP, Griffin M, O'Brien T, O'Neill C. PLoS One. 2018 Nov 26;13(11):e0207960. doi: 10.1371/journal.pone.0207960. eCollection 2018. PMID: 30475893 |
Start Year | 2014 |
Description | Wellcome Trust-HRB Irish Clinical Academic Training (ICAT) Programme |
Organisation | Health Research Board (HRB) |
Country | Ireland |
Sector | Public |
PI Contribution | Wellcome Trust in combination with Health Research Board (RoI) and Public Health Agency R&D Division have invested in an Irish Clinical Academic Training (ICAT) Programme involving six partner universities in Ireland (QUB, UCD, RSCI, TCD, UCC and NUI Galway). I am the director of the Clinical Academic Training Programme in Northern Ireland (QUB and NIMDTA). Wellcome Trust, HRB and PHA R&D Division investment is more than £10 million over the next 5 years. Eight ICAT fellows will be recruited each year up to at least 2021. Each fellowship is for 4 years (Year 1 - clinical academic training; Years 2-4 postgraduate research for PhD). US Ireland R&D Partnership grants have enabled high quality genomics research projects to be completed through collaborations between QUB, UCD, Broad Institute (MIT & Harvard) and University of Helsinki. This high quality research underpins several projects offered within the ICAT programme in Ireland. |
Collaborator Contribution | Queen's University is a full partner in the Wellcome ICAT programme which involves six universities in Ireland (Trinity College Dublin, University College Dublin, Royal College of Surgeons Ireland, NUI Galway, Queens University Belfast and University College Cork) |
Impact | Eight ICAT programme clinical research fellowships have been awarded in the first round of applications (2016-17) with starting date for these clinical academic trainees in July 2017 |
Start Year | 2016 |
Description | Wellcome Trust-HRB Irish Clinical Academic Training (ICAT) Programme |
Organisation | Public Health Agency (PHA) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Wellcome Trust in combination with Health Research Board (RoI) and Public Health Agency R&D Division have invested in an Irish Clinical Academic Training (ICAT) Programme involving six partner universities in Ireland (QUB, UCD, RSCI, TCD, UCC and NUI Galway). I am the director of the Clinical Academic Training Programme in Northern Ireland (QUB and NIMDTA). Wellcome Trust, HRB and PHA R&D Division investment is more than £10 million over the next 5 years. Eight ICAT fellows will be recruited each year up to at least 2021. Each fellowship is for 4 years (Year 1 - clinical academic training; Years 2-4 postgraduate research for PhD). US Ireland R&D Partnership grants have enabled high quality genomics research projects to be completed through collaborations between QUB, UCD, Broad Institute (MIT & Harvard) and University of Helsinki. This high quality research underpins several projects offered within the ICAT programme in Ireland. |
Collaborator Contribution | Queen's University is a full partner in the Wellcome ICAT programme which involves six universities in Ireland (Trinity College Dublin, University College Dublin, Royal College of Surgeons Ireland, NUI Galway, Queens University Belfast and University College Cork) |
Impact | Eight ICAT programme clinical research fellowships have been awarded in the first round of applications (2016-17) with starting date for these clinical academic trainees in July 2017 |
Start Year | 2016 |
Description | Wellcome Trust-HRB Irish Clinical Academic Training (ICAT) Programme |
Organisation | Wellcome Trust |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Wellcome Trust in combination with Health Research Board (RoI) and Public Health Agency R&D Division have invested in an Irish Clinical Academic Training (ICAT) Programme involving six partner universities in Ireland (QUB, UCD, RSCI, TCD, UCC and NUI Galway). I am the director of the Clinical Academic Training Programme in Northern Ireland (QUB and NIMDTA). Wellcome Trust, HRB and PHA R&D Division investment is more than £10 million over the next 5 years. Eight ICAT fellows will be recruited each year up to at least 2021. Each fellowship is for 4 years (Year 1 - clinical academic training; Years 2-4 postgraduate research for PhD). US Ireland R&D Partnership grants have enabled high quality genomics research projects to be completed through collaborations between QUB, UCD, Broad Institute (MIT & Harvard) and University of Helsinki. This high quality research underpins several projects offered within the ICAT programme in Ireland. |
Collaborator Contribution | Queen's University is a full partner in the Wellcome ICAT programme which involves six universities in Ireland (Trinity College Dublin, University College Dublin, Royal College of Surgeons Ireland, NUI Galway, Queens University Belfast and University College Cork) |
Impact | Eight ICAT programme clinical research fellowships have been awarded in the first round of applications (2016-17) with starting date for these clinical academic trainees in July 2017 |
Start Year | 2016 |
Description | A talk for Association of Clinical Biochemists on Diabetic Kidney Disease |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Approx 50 Clinical Biochemists attended a regional meeting and I made a presentation on diabetic kidney disease (DKD) including genetic and epigenetic risk factors associated with DKD. This triggered broader interest in the application of "-omics" approaches to clinical chemistry populations |
Year(s) Of Engagement Activity | 2017 |
Description | Annual general meeting - Northern Ireland Kidney Patients Association |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Talk about the translation of research into improved services for patients and families |
Year(s) Of Engagement Activity | 2017 |
Description | Clinical academic training presentation at national meeting (UK Kidney Week) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A workshop on encouraging clinical trainees to consider academic pathways and longer term scholarly projects including all aspects of clinical research |
Year(s) Of Engagement Activity | 2018 |
Description | European Renal Association - European Dialysis & Transplant Association (ERA-EDTA), annual scientific meeting, Madrid 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited lecture on Genetics of Diabetic Kidney Disease at ERA-EDTA annual conference in Madrid, Spain |
Year(s) Of Engagement Activity | 2017 |
Description | Hyperkalaemia revisited |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on the evidence base for management of hyperkalaemia in end-stage renal disease |
Year(s) Of Engagement Activity | 2018 |
Description | International Society of Nephrology Forefronts Meeting, Shenzhen, China |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | I presented a talk on epigenetic mechanisms and their role in diabetic kidney disease which triggered an extensive discussion at the meeting and has generated new research ideas Multiple requests from international collaborators to consider new research studies |
Year(s) Of Engagement Activity | 2015 |
Description | Irish Clinical Academic Training (ICAT) programme workshop for ICAT fellows, hosted by Queen's University Belfast |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Greater awareness of ICAT fellows on the varied routes through integrated clinical academic training to positions of leadership |
Year(s) Of Engagement Activity | 2020 |
Description | NIMDTA-Queens University Belfast-Ulster Medical Society: Trainee Research Day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | A conference for clinical trainees to showcase all aspects of integrated clinical and academic training and opportunities for research in clinical education as well as basic science to clinical trials |
Year(s) Of Engagement Activity | 2018 |
Description | Northern Ireland Science Festival: The future of Kidney Research is STEAM powered |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Mixed programme of science talks from myself and postdoctoral research fellow plus arts-based therapy for dialysis patients. Introduction to a play written by an organ transplant recipient. Music from blues band to finish the event (monies raised to kidney patient support charities). |
Year(s) Of Engagement Activity | 2022 |
URL | https://pure.qub.ac.uk/en/activities/the-future-of-kidney-research-is-steam-powered-public-engagemen... |
Description | Patient and carers fundraising group |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Report to Northern Ireland Kidney Research Fund illustrated by the research highlights 2017-18 |
Year(s) Of Engagement Activity | 2018 |
Description | Patient group workshop |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation and discussion of funded research programme, postgraduate research student activity, post-doctoral research training and the implications for service development. Talk and discussion included the impact of genomics on diagnosis and management of renal disease with special focus on diabetic kidney disease |
Year(s) Of Engagement Activity | 2017 |
Description | Patient workshop exploring choices in renal replacement therapy |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Workshop supported by Kidney Care UK and Northern Ireland Kidney Research Fund with an international faculty. The workshop had multiple elements exploring choices of renal replacement therapy for persons with end-stage renal disease |
Year(s) Of Engagement Activity | 2018 |
Description | Research Workshop |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | NEPHSTROM Plenary Meeting in Belfast with delegates from UK, RoI, Italy, Germany and Netherlands discussing next steps in genetic and cell therapies for diabetic kidney disease. |
Year(s) Of Engagement Activity | 2017 |
Description | Research for Clinicians |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Research for Clinicians - Conference and workshop for clinical trainees, students and senior doctors Sponsors - Queen's University; Northern Ireland Medical and Dental Training Agency; Ulster Medical Society Guest lecture - Professor Fionnaula Ni Ainle and patient representative promoting PPI |
Year(s) Of Engagement Activity | 2019 |
Description | Royal College of Physicians of Edinburgh - Regional Update in Medicine |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | ~80 clinicians attended Regional Update in Medicine meeting organised by Royal College of Physicians. I presented a talk on the rising epidemic of Diabetic Kidney Disease (illustrated in part with examples of the research supported by this award) |
Year(s) Of Engagement Activity | 2018 |
Description | STEAMING KIDNEYS: WHERE ART AND SCIENCE COLLIDE |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Engagement between public, patients, clinicians and researchers leading to interest in further collaborative research and dissemination events. Presentations from scientists, clinicians, nursing academics and administrator for the Renal Arts Group Overview of three kidney charities (NIKPA, NIKRF and Kidney Care UK) from local representatives of these organisations. |
Year(s) Of Engagement Activity | 2023 |
URL | https://accidentaltheatre.co.uk/box-office/steaming-kidneys |
Description | Using Evidence in Research and Clinical Practice |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Research ethics and governance talk to clinical trainees as part of a 1-day workshop on Using Evidence sponsored by the Northern Ireland Postgraduate Deanery and open to medical and dental graduates |
Year(s) Of Engagement Activity | 2018 |
Description | Wellcome-HRB Irish Clinical Academic Training programme induction meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Tutorials on undertaking a PhD, designing a project, research governance and ethics, skills gap analysis |
Year(s) Of Engagement Activity | 2018 |