King’s College London Confidence in Concept

Lead Research Organisation: King's College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Coolen A (2017) Replica analysis of overfitting in regression models for time-to-event data in Journal of Physics A: Mathematical and Theoretical

 
Description Co-opted onto BTS council to represent Basic Science
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description BBSRC research grant
Amount £442,305 (GBP)
Funding ID BB/S005560/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 12/2021
 
Description BHF Translational Award (First-phase ejection fraction as a diagnostic marker and therapeutic target in cardiac disease)
Amount £146,961 (GBP)
Funding ID TG/17/2/33054 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 07/2019
 
Description CAR T-cell mediated co-targeting of MUC1 and HER2 to achieve precision immunotherapy of breast cancer
Amount £229,844 (GBP)
Organisation Breast Cancer Now 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2022
 
Description CDT student
Amount £96,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 09/2020
 
Description Chemistry and medicinal chemistry of tris(hydroxypyridinone) (THP) and derivatives thereof
Amount £50,000 (GBP)
Organisation Theragnostics Limited 
Start 06/2018 
End 05/2019
 
Description Clinical Research Training Fellowship (Hannah Wilkinson)
Amount £270,889 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Enabling clinical translation of a novel activation-repolarisation time metric for improved identification of optimal catheter ablation sites
Amount £287,947 (GBP)
Funding ID PG/16/81/32441 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2017 
End 04/2020
 
Description Multidisciplinary project award
Amount £501,608 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description Research Grants
Amount £5,180,000 (GBP)
Funding ID MR/R014043/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2018 
End 05/2022
 
Description Analysis of Swedish national cancer data 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution My research team contribute innovative statistical methodology and know-how, implemented in software.
Collaborator Contribution My partner contributed large scale Swedish national epidemiological cancer data.
Impact There are no outcomes yet. Outcomes will take the form of research publications and possibly joint grant applications.
Start Year 2017
 
Description Analysis of complex epidemiological data from AMD patients 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution My research team contribute innovative statistical methodology and know-how, implemented in software.
Collaborator Contribution My partner provided clinical and epidemiological data from AMD patients (the Rotterdam Study and the EU network Eye-Risk)
Impact There are no outcomes yes. Outcomes will take the form of joint publications and possible joint grant applications.
Start Year 2017
 
Description Els 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Perform experiments
Collaborator Contribution Provides expert advice
Impact Provides expert advice on genetic manipulation of stem cells
Start Year 2017
 
Description Interdisciplinary research collaboration towards clinical implementation 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution The MRI research sequence for fast 3D T2 mapping is implemented on several MRI scanners at the Guy's and St Thomas Hospital Trust to be used in collaborative research projects towards clinical implementation. To extend the research to application in radiotherapy, diagnostic multi-parametric cancer imaging.
Collaborator Contribution Use the new research sequence as an add on in their clinical research studies, compare to standard imaging methods towards clinical implementation. Give feedback on image quality, robustness measures.
Impact Conference proceedings published, journal publications and grant proposals in preparation
Start Year 2016
 
Description Latent class analysis of data from colorectal cancer trials 
Organisation Mayo Clinic Hospital
PI Contribution My research team contribute innovative statistical methodology and know-how, implemented in software.
Collaborator Contribution My partners contribute data from clinical trials.
Impact This is a multidisciplinary collaboration. Outputs will take the form of clinical research papers and possible joint grant applications.
Start Year 2017
 
Description Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology 
Organisation Jagiellonian University
Country Poland 
Sector Academic/University 
PI Contribution Organiser and chair of the Task Force
Collaborator Contribution Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report.
Impact n/a
Start Year 2017
 
Description Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Organiser and chair of the Task Force
Collaborator Contribution Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report.
Impact n/a
Start Year 2017
 
Description Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Organiser and chair of the Task Force
Collaborator Contribution Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report.
Impact n/a
Start Year 2017
 
Description Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology 
Organisation University of Groningen
Country Netherlands 
Sector Academic/University 
PI Contribution Organiser and chair of the Task Force
Collaborator Contribution Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report.
Impact n/a
Start Year 2017
 
Description Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology 
Organisation University of Milan
Country Italy 
Sector Academic/University 
PI Contribution Organiser and chair of the Task Force
Collaborator Contribution Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report.
Impact n/a
Start Year 2017
 
Description Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology 
Organisation University of Vienna
Country Austria 
Sector Academic/University 
PI Contribution Organiser and chair of the Task Force
Collaborator Contribution Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report.
Impact n/a
Start Year 2017
 
Description Tetramer 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution We will use the reagents provided for the development of the research project
Collaborator Contribution Provide unique reagents required for the project
Impact The reagents provided by NIH are necessary for the progress and development of the research project
Start Year 2014
 
Title Bur with Bioactive Materials 
Description 'Biobur': a new instrument for minimum intervention dentistry 
IP Reference GB1713166.5 
Protection Patent application published
Year Protection Granted
Licensed No
Impact pending
 
Title Measurement of cardiac first phase ejection fraction 
Description detection of early stage heart failure 
IP Reference GB1603216.1 
Protection Patent application published
Year Protection Granted
Licensed No
Impact None yet
 
Title Accelerated 3D 1 mm isotropic T2w-Imaging of the Prostate in less than 3 min 
Description T2-weighted imaging is a key contrast in magnetic resonance imaging (MRI) for prostate cancer diagnostics and stratification. Three dimensional (3D), isotropic T2-weighted imaging of the prostate requires a long acquisition time. We have developed a 3D T2-prepared multi- shot bSSFP acquisition with a variable density undersampled trajectory and TV-SENSE reconstruction. We have published results from a healthy volunteer study and demonstrated that 3D 1 mm isotropic resolution T2-weighted images of the prostate can be acquired in 2 min 45 s, with image quality that is comparable to the clinical standard turbo spin echo sequences but only takes 1/3 of the acquisition time. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact This sequence is currently implemented at the hospital and tested in a pilot patient study. 
URL https://www.ismrm.org/18/program_files/Tu03.htm
 
Title Accelerated 3D and quantitative T2-mapping with dictionarybased matching for prostate cancer imaging 
Description Prostate cancer (PCa) is one of the most frequent types of cancer in men. Multiparametric MRI (mpMRI) of the prostate, which consists of the acquisition of 2D T2weighted (T2w), dif- fusionweighted and gadoliniumbased dynamic contrast enhanced images, has shown great potential for diagnosis of PCa and has been shown to correlate with pathological Gleason score. Whereas 2D T2w images are evaluated in a qualitative manner, quantitative MRI directly relates the MR signals to quantitative tissue 
Type Diagnostic Tool - Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2019
Development Status Under active development/distribution
Impact We have published results from an initial healthy volunteer pilot study that accurate and rapid 3D T2mapping of the prostate is feasible in under 3 minutes and can be used in an mpMRI protocol for PCa detection and characterization. We have implemented the sequence on clinical scanners throughout the hospital to acquire pilot patient data towards clinical translation. 
URL https://onlinelibrary.wiley.com/doi/10.1002/mrm.27540
 
Description Debate at National British Society for Histocompatibility and Immunogenetics meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at Keynote debate
Year(s) Of Engagement Activity 2017
URL http://www.bshi.org.uk/html/bshi_2017.html
 
Description Frontiers in Transplantation Course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation workshop facilitator
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A course for clinicians and scientists interested in translational transplantation research. Attended by more than 80 people in 2014. I was highest rated speaker in 2015 and 2017
Second URL relating to 2013 course: https://www.youtube.com/watch?v=ZlzUAzOj47A

Extremely good feedback scores form participants has ensured we will make this an annual event
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
URL https://www.youtube.com/watch?v=dRnOEYs9hCQ
 
Description Give me six hours to chop down a tree ... statistical tools to meet the challenges of modern medical data 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited seminar at the Mayo Clinic (Rochester, USA)
Year(s) Of Engagement Activity 2016
URL https://nms.kcl.ac.uk/ton.coolen/seminars/Mayo2016.pdf
 
Description Heterogeneity and competing risks in cancer survival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I was invited by the University of Umea in Sweden to give a seminar.
Year(s) Of Engagement Activity 2017
 
Description How can we bond and repair carious dentine? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote presentation at the International Association for Dental Research General Session in San Francisco
Year(s) Of Engagement Activity 2017
 
Description Systems biomedicine graduate programme 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact An annual series of lectures on a wide variety of biomedical topics, for a multidisciplinary audience of postgraduate students. The aim is to break down barriers between the biomedical and the mathematical/physical sciences, and encourage young scientists to engage in multidisciplinary research.
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016
 
Description Theory of overfitting in Cox regression 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I was speaking at a conference organised at King's College London.
Year(s) Of Engagement Activity 2017
 
Description Theragnostics Annual Update 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Postgraduate students, postdocs and PIs met at Theragnostics LTD headquarter in Bracknell (February 2018) to discuss outcomes of the KCL/Theragnostics collaborative research. The full day consisted of open debates and powerpoint presentations from various participants. This was the first annual update and it was decided to run the event annually.
Year(s) Of Engagement Activity 2018
 
Description Towards a theory of overfitting in proportional hazards regression for survival data 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited research seminar at the Department of Statistics of Columbia University (New York, USA)
Year(s) Of Engagement Activity 2016
URL https://nms.kcl.ac.uk/ton.coolen/seminars/NYC2016.pdf
 
Description Undergraduate event talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Presentation in a career-event for undergraduate students from KCL and the Crick Institute
Year(s) Of Engagement Activity 2018
 
Description What data bases and statistics do we need? Meeting the challenges of data-driven precision medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk for the annual meeting of the German Opthamological Society (Berlin)
Year(s) Of Engagement Activity 2016
 
Description Workshop lectures Havana 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact International Workshop `Statistical Approaches to Systems Biology' in Havana, for young researchers mainly from Latin America and Europe. I gave a series of lectures on mathematical and statistical topics in survival analysis, and their application to cancer data analytics.
Year(s) Of Engagement Activity 2019
URL http://www.fisica.uh.cu/statphys/
 
Description Youtube video: What is an MRI scan? 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact > 700 views to date on youtube
Year(s) Of Engagement Activity 2016
URL https://youtu.be/eQoONNpKGJk