Maximising patient benefit: Leeds’ Interdisciplinary approach to translation
Lead Research Organisation:
University of Leeds
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
Publications
Ajjan R
(2022)
Oral 11ß-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial
in European Journal of Endocrinology
Arafat M
(2019)
In-situ crosslinked wet spun collagen triple helices with nanoscale-regulated ciprofloxacin release capability
in Materials Letters
Clayton RN
(2016)
Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study.
in The lancet. Diabetes & endocrinology
Crowley RK
(2016)
SFRP2 Is Associated with Increased Adiposity and VEGF Expression.
in PloS one
Dineen R
(2017)
Acromegaly.
in QJM : monthly journal of the Association of Physicians
El-Sherbiny YM
(2020)
B Cell Tetherin: A Flow Cytometric Cell-Specific Assay for Response to Type I Interferon Predicts Clinical Features and Flares in Systemic Lupus Erythematosus.
in Arthritis & rheumatology (Hoboken, N.J.)
Hardy RS
(2016)
11ß-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.
in The Journal of pathology
Jenkinson C
(2016)
High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum.
in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Larner DP
(2016)
Male 11ß-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease.
in Endocrinology
Macleod T
(2019)
Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response.
in Frontiers in immunology
Mahmoud K
(2017)
Musculoskeletal manifestations of systemic lupus erythmatosus.
in Current opinion in rheumatology
Md Yusof MY
(2017)
Predicting and managing primary and secondary non-response to rituximab using B-cell biomarkers in systemic lupus erythematosus.
in Annals of the rheumatic diseases
Md Yusof MY
(2018)
Prediction of autoimmune connective tissue disease in an at-risk cohort: prognostic value of a novel two-score system for interferon status.
in Annals of the rheumatic diseases
Morgan SA
(2016)
Glucocorticoids and 11ß-HSD1 are major regulators of intramyocellular protein metabolism.
in The Journal of endocrinology
Owston HE
(2020)
Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities.
in International journal of molecular sciences
Psarras A
(2020)
Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity.
in Nature communications
Psarras A
(2021)
TNF-a Regulates Human Plasmacytoid Dendritic Cells by Suppressing IFN-a Production and Enhancing T Cell Activation.
in Journal of immunology (Baltimore, Md. : 1950)
Stewart PM
(2016)
Exploring Inpatient Hospitalizations and Morbidity in Patients With Adrenal Insufficiency.
in The Journal of clinical endocrinology and metabolism
Wang Y
(2023)
Automated quantification of 3D wound morphology by machine learning and optical coherence tomography in type 2 diabetes.
in Skin health and disease
Weigel M
(2017)
Immediate versus modified release hydrocortisone in mitotane-treated patients with adrenocortical cancer.
in Clinical endocrinology
Yin J
(2021)
Hierarchically Assembled Type I Collagen Fibres as Biomimetic Building Blocks of Biomedical Membranes.
in Membranes
Zayat A
(2019)
Defining inflammatory musculoskeletal manifestations in systemic lupus erythematosus
in Rheumatology