Zika: A prospective case-control study to examine the role of Zika virus in Guillain-Barré syndrome in Brazil

Lead Research Organisation: University of Liverpool

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Guillain-Barré Syndrome (GBS) is an acute immune-mediated disease of the peripheral
nervous system which can lead to death or debilitating neurological disability. The number of
GBS cases in Zika-affected areas is rising sharply, but the WHO has urged caution in
attributing them to the virus. Through the Zika Neurology Network, established in 2015, we
will conduct a prospective case-control study of GBS in Rio de Janeiro, focusing on Zika as a
risk factor. The project builds on Liverpool expertise in flavivirus neurological disease, Public
Health England’s diagnostic capabilities, flavivirus research at the Oswaldo Cruz Foundation
(Fiocruz), Rio di Janeiro, and the International GBS Outcome Study’s experience.
We will recruit 60 adults with GBS referred to major hospitals in the Network, with scope to
expand if needed. GBS will be defined through recognised clinical and electrophysiological
criteria, and Zika infection diagnosed with investigations already established at Fiocruz,
including PCR of blood and urine, and IgM and IgG ELISA of blood. Outcome will be assessed
at 2 months. Four community controls will be recruited for each case.
Underpinned by the NIHR Health Protection Research Unit in Emerging and Zoonotic
Infections, which already has team members in Rio supporting protocol, case record form,
and diagnostic developments, the project provides excellent value for money, and is ready to
deliver in a timely manner. Within nine months our study will define the role of Zika as a risk
factor for GBS, to help individual patient management, and importantly to support public
health and policy decisions.

Publications

10 25 50
publication icon
Birley HD (2018) Comment on CME Infectious diseases. in Clinical medicine (London, England)

publication icon
Brasil P (2016) Guillain-Barré syndrome associated with Zika virus infection. in Lancet (London, England)

publication icon
Ellul M (2018) Acute encephalitis - diagnosis and management. in Clinical medicine (London, England)

publication icon
Fernandez C (2016) Neurotropic Viral Infections

publication icon
Gadama YG (2017) Challenges of stroke management in resource-limited settings: A case-based reflection. in Malawi medical journal : the journal of Medical Association of Malawi

publication icon
Griffiths M (2018) Response in Clinical Medicine

publication icon
Griffiths MJ (2018) Management of acute meningitis. in Clinical medicine (London, England)

 
Description 2016-present Member, WHO Consultation on Considerations for Regulatory Expectations of Zika vaccines for use during an Emergency
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact WHO policy on Zika, especially in relation to requirements for vaccine development
URL http://www.who.int/immunization/research/development/WHO_UNICEF_Zikavac_TPP_Feb2017.pdf
 
Description Member, UK Government's Zika Outbreak Precautionary Scientific Advisory Group for Emergencies (preSAGE)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Member, UK Government's Zika Outbreak Precautionary Scientific Advisory Group for Emergencies (preSAGE) Supported policy on travel, risks assessments, developing diagnosis, etc
URL https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/584350/160203_PreSAGE_Zika...
 
Description A phase I study of recombinant poxvirus Zika vaccine. Co-applicant
Amount £4,700,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2017 
End 05/2021
 
Description Adjuvant free vaccines and companion diagnostics to control emerging flaviviruses. Co-applicant
Amount £382,974 (GBP)
Funding ID 971526 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 01/2017 
End 01/2018
 
Description Clinical Research Career Development Fellowship (to Lance Turtle): Understanding cross-reactive immunity to Japanese encephalitis
Amount £573,824 (GBP)
Funding ID 205228/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 07/2019
 
Description Development of a novel blood test to aid the diagnosis of bacterial meningitis.
Amount £791,702 (GBP)
Funding ID MR/R015406/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 05/2021
 
Description European Union Horizon 2020
Amount € 11,000,000 (EUR)
Organisation European Union 
Sector Public
Country European Union (EU)
Start 10/2016 
End 09/2020
 
Description Global Challenges Research Fund. One Health Regional Network for the Horn of Africa (HORN). Co-applicant
Amount £7,700,000 (GBP)
Funding ID BB/P027954/1 
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 11/2017 
End 10/2020
 
Description Global Health Research Group in Acute Brain Infections Principle Investigator
Amount £1,999,761 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 08/2018 
End 07/2021
 
Description Health Protection Research Unit in Emerging and Zoonotic Infections - Extension. Chief Investigator / Director
Amount £781,973 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2019 
End 05/2020
 
Description Improving diagnosis of brain infections in Indonesia using novel and established molecular diagnostic tools. Co-applicant
Amount £330,149 (GBP)
Funding ID MR/S019960/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 01/2022
 
Description NIHR Senior Investigator
Amount £15,000 (GBP)
Funding ID NF-SI-0514-10177 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2020
 
Description A*STAR Singapore 
Organisation Agency for Science, Technology and Research (A*STAR)
Department Singapore Immunology Network (SIgN)
Country Singapore 
Sector Academic/University 
PI Contribution Partnership with Prof Lisa Ng on EV71
Collaborator Contribution Partnership with Prof Lisa Ng on EV71
Impact Non
Start Year 2012
 
Description Brain Infections Global 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Department Fiocruz Pernambuco
Country Brazil 
Sector Hospitals 
PI Contribution Collaboration on NIHR Global health Research Group
Collaborator Contribution Collaboration on NIHR Global health Research Group
Impact see publications
Start Year 2019
 
Description Fast Track Diagnostics 
Organisation Fast Track Diagnostics Ltd.
Country Malta 
Sector Private 
PI Contribution A new partnership where we evalutae new diagnostics
Collaborator Contribution Development of kits
Impact none yet
Start Year 2014
 
Description Fundação Oswaldo Cruz, (FIOCRUZ) collaboration on Zika 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Country Brazil 
Sector Public 
PI Contribution Collaboration on Zika
Collaborator Contribution Collaboration on Zika
Impact New publications, and grants, see other sections
Start Year 2016
 
Description Public Health England 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Collaborative work on Encephalitis since 2007
Collaborator Contribution Collaborative work on Encephalitis since 2007
Impact Lancet ID publication 2010 New National Guidelines New Programme Grant
Start Year 2007
 
Title University of Liverpool (Mike Griffiths/Tom Solomon) 
Description Diagnosing acute bacterial meningitis Our novel approach to distinguishing bacterial from viral brain infections by measuring host response genes in the blood has been patented and is due to be licenced soon with SME industrial partner with Fast Track Diagnostics 
IP Reference GB1606537.7 
Protection Patent application published
Year Protection Granted 2016
Licensed Yes
Impact Strengthened collaboration with industrial partner FastTrack Diagnostics
 
Description Published book: Roald Dahl's Marvellous Medicine 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Popular Science Book, with associated tom radio, newspaper coverage
talks, lectures, schools
Year(s) Of Engagement Activity 2016
URL http://www.tomsolomon.co.uk
 
Description Roald Dahl's Marvellous Medicine, Family Show, presented at Edinburgh Festival Fringe 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Roald Dahl's Marvellous Medicine, Family Show, presented at Edinburgh Festival Fringe, and BBC, and West Ed Theatre (Leicester Square) . Audience >2000 in person. A chance to use a novel approach to explain some of our research (and other aspects of medical science) to a new audience.
Year(s) Of Engagement Activity 2017