University of Manchester Momentum Award - Dementias
Lead Research Organisation:
University of Manchester
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The University of Manchester (UoM) has significant strengths in dementias research but we also have a wealth of expertise across the University in other disciplines and/or new technologies. The aim of this Momentum Award application is to unlock UoM’s untapped potential for dementias research, open up new scientific areas, encourage innovative high risk projects, and bring high level expertise and novel ideas/technologies from other disciplines (e.g. nanomedicine, materials, bioengineering, vascular biology, cell matrix biology, physics, health informatics) in to the dementia field. Through bringing new ways of thinking and new approaches across disciplinary interfaces we aim to open up new scientific avenues for dementias research, involving novel science and technology, and the creation of enabling platforms.
We request £700k from the Momentum Award, matched with £380k of internal UoM funds, to pump-prime innovative cross-disciplinary biomedical dementia research. We will allocate this funding across a small number of projects (approx. 8) with particular emphasis on bringing new approaches to dementia research aligned with our areas of key strengths in proteostasis dysfunction, neuroinflammation, neurovascular dysfunction, cognitive-clinical neuroscience and neuroimaging, and discovery of endotypes, targets and biomarkers. Priority will be given to projects that bring innovative science, new approaches and/or someone new to dementia research and which are cross-disciplinary, involve new technology and/or create enabling infrastructure. We are keen to encourage the development of high flyers (both permanent and fixed term staff). The Momentum Award will enable us to build both capacity and connectivity in dementia research in UoM through rapidly accelerating the introduction of new ways of thinking, novel approaches and new technology into our core areas of dementia research strength, which ultimately will benefit the dementia research community in the UK.
We request £700k from the Momentum Award, matched with £380k of internal UoM funds, to pump-prime innovative cross-disciplinary biomedical dementia research. We will allocate this funding across a small number of projects (approx. 8) with particular emphasis on bringing new approaches to dementia research aligned with our areas of key strengths in proteostasis dysfunction, neuroinflammation, neurovascular dysfunction, cognitive-clinical neuroscience and neuroimaging, and discovery of endotypes, targets and biomarkers. Priority will be given to projects that bring innovative science, new approaches and/or someone new to dementia research and which are cross-disciplinary, involve new technology and/or create enabling infrastructure. We are keen to encourage the development of high flyers (both permanent and fixed term staff). The Momentum Award will enable us to build both capacity and connectivity in dementia research in UoM through rapidly accelerating the introduction of new ways of thinking, novel approaches and new technology into our core areas of dementia research strength, which ultimately will benefit the dementia research community in the UK.
Organisations
Publications
Fox S
(2022)
Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study.
in JMIR mHealth and uHealth
Hadjidemetriou M
(2021)
Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease.
in ACS nano
Haley MJ
(2019)
Microglial Priming as Trained Immunity in the Brain.
in Neuroscience
Jarosz-Griffiths H
(2019)
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-ß oligomers
in Journal of Biological Chemistry
Lea-Carnall CA
(2020)
GABA Modulates Frequency-Dependent Plasticity in Humans.
in iScience
Lea-Carnall CA
(2019)
Effect of tACS on frequency-dependent cortical plasticity
Moxon SR
(2019)
Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation.
in Materials science & engineering. C, Materials for biological applications
Potjewyd G
(2018)
Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.
in Trends in biotechnology
Redondo-Castro E
(2018)
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
in Scientific reports
Rowland HA
(2018)
Modelling Sporadic Alzheimer's Disease Using Induced Pluripotent Stem Cells.
in Neurochemical research
Strangward P
(2018)
Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.
in Proceedings of the National Academy of Sciences of the United States of America
Zhang W
(2023)
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
in Frontiers in cellular neuroscience
Description | Understanding the biophysical basis of functional Magnetic Resonance Spectroscopy measurements in the human brain. |
Amount | £100,000 (GBP) |
Funding ID | 2453604 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 03/2024 |
Description | what role do microglia play in C9orf72-linked frontotemporal dementia |
Amount | £210,334 (GBP) |
Organisation | Alzheimer's Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2022 |
Description | 'Effect of tACS on frequency-dependent cortical plasticity' Organisation for human brain mapping conference proceedings 2019, Rome |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 'Effect of tACS on frequency-dependent cortical plasticity' Organisation for human brain mapping conference proceedings 2019, Rome |
Year(s) Of Engagement Activity | 2019 |
Description | A total of four successful PPI events took place during the project. Software development work for the MyMindCheck app was completed successfully and this is an important output from the project. Laura Brown gave an oral presentation about MyMindCheck at both the IAGG-ER 2019 Congress and the British Society of Gerontology 48th Annual Conference. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A total of four successful PPI events took place during the project. Software development work for the MyMindCheck app was completed successfully and this is an important output from the project. Laura Brown gave an oral presentation about MyMindCheck at both the IAGG-ER 2019 Congress and the British Society of Gerontology 48th Annual Conference. |
Year(s) Of Engagement Activity | 2019 |