King’s College London Confidence in Concept

Lead Research Organisation: King's College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Chubb H (2018) The reproducibility of late gadolinium enhancement cardiovascular magnetic resonance imaging of post-ablation atrial scar: a cross-over study. in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

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Fusar-Poli P (2018) The Science of Prognosis in Psychiatry: A Review. in JAMA psychiatry

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Fusar-Poli P (2018) Ten simple rules for conducting umbrella reviews. in Evidence-based mental health

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Gopal S (2019) Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads. in Advanced materials (Deerfield Beach, Fla.)

 
Title COver figure for Advanced Materials 
Description We prepared an artistic cover image for the Gopal et al. publication on advanced materials, which was selected for cover display. 
Type Of Art Image 
Year Produced 2019 
Impact Broader dissemination of our research through the community. 
 
Description A miniaturised laser isotope ratiometer for early diagnosis of sepsis by exhaled breath analysis
Amount £298,000 (GBP)
Funding ID ST/S000690/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 09/2020
 
Description Critical role for purinergic receptors in Candida albicans infection
Amount £20,000 (GBP)
Funding ID M680 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 09/2019
 
Description ERC Starting Grant
Amount € 1,495,430 (EUR)
Funding ID 759577 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 02/2018 
End 01/2023
 
Description EU H2020 MSCA-ITN
Amount € 3,000,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2018 
End 12/2022
 
Description Health and Environmental Sciences Institute internal fund
Amount £52,935 (GBP)
Organisation Health and Environmental Sciences Institute (HESI) 
Sector Public
Country United States
Start 02/2018 
End 01/2019
 
Description Induced nutritional ketosis to improve FDG PET-CT scanning sensitivity in cancer
Amount £73,840 (GBP)
Funding ID MC_PC_17164 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 01/2020
 
Description Israeli Fellowship
Amount £2,550 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description KCL Application for a Mental Health Data Pathfinder award
Amount £1,497,000 (GBP)
Funding ID MC_PC_17214 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description PROSPER Study
Amount £60,000 (GBP)
Organisation Theragnostics Limited 
Start 01/2019 
End 12/2020
 
Description PhD Studentship
Amount £69,888 (GBP)
Funding ID A1501 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Project Grant
Amount £192,952 (GBP)
Funding ID NC/R001006/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
Country United Kingdom
Start  
 
Description Candidalysin molecular dynamics 
Organisation Masaryk University
Country Czech Republic 
Sector Academic/University 
PI Contribution We provide the Candidalysin sequence
Collaborator Contribution Determine Candidalysin structure via molecular dynamic simulations
Impact Currently onging
Start Year 2017
 
Description Collaboration with Andrew Beavil and Sophia Karagiannis 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We defined the concept and grant application
Collaborator Contribution Provoded expertise on antibody cloning
Impact No outputs as yet as collaboration only commenced in February 2018
Start Year 2018
 
Description Collaboration with Jo Spencer (KCL), Susanne Heck (GSTT-BRC), Fuidigm 
Organisation Fluidigm Canada Inc
PI Contribution Validated IHC antibodies on appendix and colorectal cancer samples to be tagged for use on Hyperion
Collaborator Contribution Fluidigm provided a panel of tagged antibodies to test on appendix; Susanne Heck and her team at the BRC mass cytometry facilities provided expertise for tritration and tagging; Jo Spencer is co-I on the grant and is the expert on gastrointenstinal immunology
Impact The collaboration is highly disciplinary and involves mucosal immunology (Jo Spencer); Time of Flight Mass Cytometry (CyTOF; Susanne Heck, Fluidigm); Genomics and data analysis (Francesca Ciccarelli)
Start Year 2018
 
Description Fungal peptide toxins 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution We provide the Candidalysin sequence
Collaborator Contribution Undertake computational analysis to identify similar fungal peptide toxins
Impact Identified approx 2,000 possible toxins
Start Year 2016
 
Description Local drug delivery for cornea endothelium 
Organisation University of Parma
Country Italy 
Sector Academic/University 
PI Contribution We demonstrated that nanoneedles can directly deliver nucleic acids to the endothelium of the cornea, which we are now planning to use for therapeutic purposes.
Collaborator Contribution The partner provided expertise in cornea disease, the cell biology expertise and the access to clinical samples.
Impact The collaboration has recently been established. We have determined the feasibility of the approach and move forward to translating it. The collaboration is multidisciplinary, it involves our expertise in biomaterials and drug delivery with the partners expertise in medical practice, regenerative medicine and cell/molecular biology.
Start Year 2017
 
Description PET lead in multicentre PSMA Trial 
Organisation Beatson Institute for Cancer Research
Department Beatson Advanced Imaging Resource
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Imaging (PET) lead for the trial
Collaborator Contribution Prof H leung is PI at the Beatson
Impact study in start up
Start Year 2018
 
Description The transcriptome of bone marrow and nasal polyp plasma cells. 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution I provided the RNA isolated from various bone marrow and nasal polyp cell population for microarray analysis
Collaborator Contribution Generated cDNA, labeled the the cDNA and hybridised onto a human genome U133 plus 2.0 array.
Impact None to report yet
Start Year 2018
 
Description Theragnostics Ltd (PROSPER Study) 
Organisation Theragenetics Ltd
Country United Kingdom 
Sector Private 
PI Contribution PI and research fellow running the trial
Collaborator Contribution Theragnostics Ltd have provided tracer FoC and have part funded a research fellow
Impact PROSPER Study in setup awaiting final R&D approval
Start Year 2018
 
Title Identification of novel fungal peptide toxin activating epithelial cells 
Description Novel fungal peptide toxin activating epithelial cells 
IP Reference WO2014167335 
Protection Patent granted
Year Protection Granted 2014
Licensed No
Impact N/A
 
Title Gazele: Microscale Brain Network Dynamics 
Description Software package for the complete study, data manipulation and modelling of the dynamics and structure of complex brain networks. It requires zero knowledge of programming or scripting and consists of two standalone applications, Gazele and Coconi. 
Type Of Technology Webtool/Application 
Year Produced 2019 
Impact None yet as still undergoing release. 
 
Description BioDynamics 2018: Dynamic network characterisation of icEEG interictal spike events in TLE patients may associate with surgical outcome (DS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Purpose
Microstructural EEG elements and their functional networks relate to many neurophysiological functions of the brain and may reveal abnormalities. The Interictal Epileptiform Discharge (IED), a hallmark graphoelement of epileptic EEG, is thought to play a key role in the formation and evolution of pathogenic networks in epilepsy. Although IEDs have previously been studied, their network attributes are still to be fully elucidated. Here, we perform a dynamic network characterisation of IEDs with high temporal selectivity, regarding this as a readily available window into the epileptic brain state.

Methods

Commonly, brain connectivity studies of epilepsy using  EEG analyse either entire recordings, including pathogenic but also normal brain activities, or lengthy rare events, such as epileptic seizures. For the first time here, we estimate pathogenic networks that characterise very brief IEDs lasting a few 10's of milliseconds, alone. We use an inverse power method for estimation of sparse principal component analysis in order to reveal connectivity properties that are consistent across subjects. Finally, we employ centrality measures (eg. betweenness, eigencentrality, closeness) to identify areas that are either influential or play an important role in the IED network function.

Results

In a preliminary analysis of four exemplar patients, we examined their first EEG at initial epilepsy onset; subsequently, two proved to be treatment-responsive and two were treatment-resistant. We show a difference in their network features. Specifically, IED networks differ in their modularity.

Conclusion

We conclude that network investigation of IEDs may reveal predictive biomarkers for early identification of treatment outcome.
Year(s) Of Engagement Activity 2018
 
Description Biological Surfaces and Interfaces FEBS workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Around 160 international leading experts interested in biological surfaces gathered to discuss the latest development on the subject. I was selected among few early career researcher to give an oral presentation on my research followed by Q&A. This raised the awareness and interest of my work and future engagements with the conference organization.
Year(s) Of Engagement Activity 2017
URL https://mimeresearch.com/biointerfaces2017/
 
Description British Association of Urological Surgeons 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact British Association of Urological Surgeons
Lecture on state-of-the-art PET imaging in prostate cancer and update on PROSPER Study
Year(s) Of Engagement Activity 2018
 
Description Computational Biomarkers in Early Identification and Prediction of Intractable Epilepsy (DS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Purpose
Microstructural EEG elements and their functional networks relate to many neurophysiological functions of the brain and may reveal abnormalities. The Interictal Epileptiform Discharge (IED), a hallmark graphoelement of epileptic EEG, is thought to play a key role in the formation and evolution of pathogenic networks in epilepsy. Although IEDs have previously been studied, their network attributes are still to be fully elucidated. Here, we perform a dynamic network characterisation of IEDs with high temporal selectivity, regarding this as a readily available window into the epileptic brain state.

Methods

Commonly, brain connectivity studies of epilepsy using EEG analyse either entire recordings, including pathogenic but also normal brain activities, or lengthy rare events, such as epileptic seizures. For the first time here, we estimate pathogenic networks that characterise very brief IEDs lasting a few 10's of milliseconds, alone. We use an inverse power method for estimation of sparse principal component analysis in order to reveal connectivity properties that are consistent across subjects. Finally, we employ centrality measures (eg. betweenness, eigencentrality, closeness) to identify areas that are either influential or play an important role in the IED network function.

Results

In a preliminary analysis of four exemplar patients, we examined their first EEG at initial epilepsy onset; subsequently, two proved to be treatment-responsive and two were treatment-resistant. We show a difference in their network features. Specifically, IED networks differ in their modularity.

Conclusion

We conclude that network investigation of IEDs may reveal predictive biomarkers for early identification of treatment outcome.
Year(s) Of Engagement Activity 2018
 
Description Fungal infections - Poland Press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview with local journalist and article published in local Press
Year(s) Of Engagement Activity 2018
 
Description LARA-VP workshop (Addressing domestic violence in mental health services) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact We held a workshop on the information mental health practitioners need in order to respond to domestic violence victimisation and perpetration safely. A draft contents of a potential manual for mental health services was provided for the participants to comment on and presentations were given on current evidence base. The workshop was attended by safeguarding nurses, directors of nursing, chief executives of domestic violence charities, senior practitioners at number of different mental health trusts, policymakers at the Department of Health and Social Care, academics and mental health service users. There was agreement that an up-to-date valuable would be helpful for mental health trusts and the lead for domestic violence at the Department of Health and Social Care agreed to disseminated to all mental health trusts. NHS Improvement and the CQC have also expressed interest and details of the manual have been widely disseminated within our own organisation e.g. King's Health Partners newsletter, NHS England, CQC, DHSC etc.
Year(s) Of Engagement Activity 2018
URL https://www.kcl.ac.uk/ioppn/depts/hspr/research/ceph/wmh/lara-vp-download-form
 
Description Meeting with NHS England (Heather Caudle, Director of Nursing for Improvement) to discuss LARA-VP intervention 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact This meeting was set-up in order for Louise Howard and Emma Yapp to explain the LARA intervention, both in terms of the pilot intervention and current progress, to Heather Caudle, Director of Nursing for Improvement at NHS England. Heather Caudle expressed concern about overall lack of identification of domestic violence within mental health services, and about the failure of nurses in both primary and secondary care to assist in this practice. LH stressed the importance of working with the domestic violence sector in delivering interventions, and summarised the LARA pilot, leading to further discussion of improved the response to domestic violence within nursing. Louise Howard and Emma Yapp to attend next meeting of Strategic Leads recently set up across the Home Office, DoH and the NHS.
Year(s) Of Engagement Activity 2018
 
Description Visit of CRUK donors 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Visit by donors to CRUK. Our MRC funded research was describe by myself and the members of the lab showed the participants some simple experiments.
Year(s) Of Engagement Activity 2018
 
Description Workshop on CyTOF 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Together with Jo Spencer and Susanne Heck we organised a workshop on solid cyTOF to introduce the technique and its potentials to the broader audience of research groups at KCL. The event was organised in collaboration with the Cancer Research UK KHP Centre and the Quantitative Genomics Programme of the School of Cancer and Pharmaceutical Sciences at King's College London.
Year(s) Of Engagement Activity 2017