King’s College London Confidence in Concept

Lead Research Organisation: King's College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

10 25 50

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Bortolomeazzi M (2019) Identification of non-cancer cells from cancer transcriptomic data in Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

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Chubb H (2018) The reproducibility of late gadolinium enhancement cardiovascular magnetic resonance imaging of post-ablation atrial scar: a cross-over study. in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

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Chubb H (2018) Optimization of late gadolinium enhancement cardiovascular magnetic resonance imaging of post-ablation atrial scar: a cross-over study. in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

 
Title COver figure for Advanced Materials 
Description We prepared an artistic cover image for the Gopal et al. publication on advanced materials, which was selected for cover display. 
Type Of Art Image 
Year Produced 2019 
Impact Broader dissemination of our research through the community. 
 
Description A miniaturised laser isotope ratiometer for early diagnosis of sepsis by exhaled breath analysis
Amount £298,000 (GBP)
Funding ID ST/S000690/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 09/2020
 
Description Asthma UK Career Development Award
Amount £250,000 (GBP)
Funding ID AUK-CDA-2019-412 
Organisation Asthma UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 10/2022
 
Description Critical role for purinergic receptors in Candida albicans infection
Amount £20,000 (GBP)
Funding ID M680 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 09/2019
 
Description ERC Starting Grant
Amount € 1,495,430 (EUR)
Funding ID 759577 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 02/2018 
End 01/2023
 
Description EU H2020 MSCA-ITN
Amount € 3,000,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2018 
End 12/2022
 
Description Fungal peptide toxins in pathogenicity and immunity
Amount £2,076,915 (GBP)
Funding ID 214229/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 04/2024
 
Description GENEPATTERN: A nanotextured platform for large-scale patterned gene delivery with single-cell resolution
Amount £12,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description Health and Environmental Sciences Institute internal fund
Amount £52,935 (GBP)
Organisation Health and Environmental Sciences Institute (HESI) 
Sector Public
Country United States
Start 02/2018 
End 01/2019
 
Description Induced nutritional ketosis to improve FDG PET-CT scanning sensitivity in cancer
Amount £73,840 (GBP)
Funding ID MC_PC_17164 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2019 
End 01/2020
 
Description Israeli Fellowship
Amount £2,550 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description KCL Application for a Mental Health Data Pathfinder award
Amount £1,497,000 (GBP)
Funding ID MC_PC_17214 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Montelukast actions in the brain; potential therapy for perinatal brain injury
Amount £30,000 (GBP)
Funding ID M833 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 02/2021
 
Description NanoCol: A nanoneedle bandage for topical intracellular COL7A1 gene therapy to accelerate wound healing in recessive dystrophic epidermolysis bullosa
Amount £320,110 (GBP)
Organisation Sohana Research Fund 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2020 
End 03/2022
 
Description Next generation molecular imaging and therapy with radionuclides
Amount £6,437,105 (GBP)
Funding ID EP/S032789/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2024
 
Description PROSPER Study
Amount £60,000 (GBP)
Organisation Theragnostics Limited 
Sector Private
Country United Kingdom
Start 01/2019 
End 12/2020
 
Description PhD Studentship
Amount £69,888 (GBP)
Funding ID A1501 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Project Grant
Amount £192,952 (GBP)
Funding ID NC/R001006/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Shedding light on platinum chemotherapy: a new mechanistic approach
Amount £250,000 (GBP)
Funding ID 209173/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 06/2022
 
Description Using Electronic Health Registers Phenotyping For The Automatic Detection of Individuals At Risk and Prediction of Psychosis
Amount £31,521 (GBP)
Funding ID RE14597 
Organisation H. Lundbeck A/S 
Sector Private
Country Denmark
Start 09/2018 
End 09/2019
 
Description Violence, Abuse and Mental Health: Opportunities for Change
Amount £1,020,181 (GBP)
Funding ID ES/S004424/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2022
 
Title Natural Language Processing (NLP) application to identify instances of violence and abuse in electronic health records from secondary mental health care 
Description The South London and Maudsley NHS Foundation Trust (SLaM) is the largest provider of secondary mental healthcare in Europe, serving a population of approximately 1.2 million people. Fully electronic health records (EHRs) were implemented in SLaM during 2006. Between 2007 and 2008, the Clinical Record Interactive Search (CRIS) application was developed to generate a psuedonymised version of SLaM's EHRs for use as a live-updated research database; CRIS data has since been extended through the development of NLP applications. The current project therefore sought to develop an NLP tool to identify instances of violence and abuse. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact One manuscript is in preparation describing the development process of the NLP application, and another is planned to break down the results of the NLP work in further detail. 
 
Title Training files for THP-PSMA PET/CT 
Description Developed set of training cases in preparation for training investigators for a phase 3 study. Each scan read by 2 experts and consensus obtained. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact Abstract at BNMS 2020 Inter-reader reliability of 68Ga-THP-PSMA PET/CT interpretation in patients with prostate cancer 
 
Description Candidalysin molecular dynamics 
Organisation Masaryk University
Country Czech Republic 
Sector Academic/University 
PI Contribution We provide the Candidalysin sequence
Collaborator Contribution Determine Candidalysin structure via molecular dynamic simulations
Impact Currently onging
Start Year 2017
 
Description Charles River Labs - validation of SPAR on respiratory data 
Organisation Charles River UK Limited
Country United Kingdom 
Sector Private 
PI Contribution Analysis of respiratory waveform data from different models/drug treatments assessing respiratory function.
Collaborator Contribution Provision of GLP respiratory plethysmography data in a model of lung fibrosis.
Impact Project grant application currently under review at NC3R. Multidisciplinary -pharmacology, physiology and mathematics.
Start Year 2018
 
Description Collaboration with Andrew Beavil and Sophia Karagiannis 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We defined the concept and grant application
Collaborator Contribution Provoded expertise on antibody cloning
Impact No outputs as yet as collaboration only commenced in February 2018
Start Year 2018
 
Description Collaboration with Jo Spencer (KCL), Susanne Heck (GSTT-BRC), Fuidigm 
Organisation Fluidigm Canada Inc
Country United States 
Sector Private 
PI Contribution Validated IHC antibodies on appendix and colorectal cancer samples to be tagged for use on Hyperion
Collaborator Contribution Fluidigm provided a panel of tagged antibodies to test on appendix; Susanne Heck and her team at the BRC mass cytometry facilities provided expertise for tritration and tagging; Jo Spencer is co-I on the grant and is the expert on gastrointenstinal immunology
Impact The collaboration is highly disciplinary and involves mucosal immunology (Jo Spencer); Time of Flight Mass Cytometry (CyTOF; Susanne Heck, Fluidigm); Genomics and data analysis (Francesca Ciccarelli)
Start Year 2018
 
Description Engineering extracellular vesicles 
Organisation University of Brescia
Country Italy 
Sector Academic/University 
PI Contribution We developed an approach to engineer the payload of extracellular vesicles by generating topgraphical substrates that stimulate endocytosis and regulate exocytosis of nanoparticle payloads.
Collaborator Contribution The group of Professor Bergese in Italy has a strong expertise in the characterisation of extracellular vesicles and is providing protocols, expertise and instrumentation for characterisation of the engineered vescicles.
Impact Collaboration just started
Start Year 2019
 
Description Fungal peptide toxins 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution We provide the Candidalysin sequence
Collaborator Contribution Undertake computational analysis to identify similar fungal peptide toxins
Impact Identified approx 2,000 possible toxins
Start Year 2016
 
Description GENEPATTERN: A nanotextured platform for large-scale patterned gene delivery with single-cell resolution 
Organisation National Research Council
Country Italy 
Sector Public 
PI Contribution We engineered nanotextured substrates that stimulate cellular uptake to mediate the patterned delivery of payloads by patterning the payload themselves on the substrates.
Collaborator Contribution The group of Dr DeStefano at CNR Napoli has expertise in patterned polymeric coatings for the controlled release of payloads. They developed a PEG coating strategy for the sustained release of the DNA loaded within the nanotextured substrates.
Impact Oral presentations of the progress from this work by Dr Valeria Caprettini from the Chiappini group at BSNM 2019, PSST 2020 and WBC 2020.
Start Year 2018
 
Description Local drug delivery for cornea endothelium 
Organisation University of Parma
Country Italy 
Sector Academic/University 
PI Contribution We demonstrated that nanoneedles can directly deliver nucleic acids to the endothelium of the cornea, which we are now planning to use for therapeutic purposes.
Collaborator Contribution The partner provided expertise in cornea disease, the cell biology expertise and the access to clinical samples.
Impact The collaboration has recently been established. We have determined the feasibility of the approach and move forward to translating it. The collaboration is multidisciplinary, it involves our expertise in biomaterials and drug delivery with the partners expertise in medical practice, regenerative medicine and cell/molecular biology.
Start Year 2017
 
Description PET lead in multicentre PSMA Trial 
Organisation Beatson Institute for Cancer Research
Department Beatson Advanced Imaging Resource
Country United Kingdom 
Sector Academic/University 
PI Contribution Imaging (PET) lead for the trial
Collaborator Contribution Prof H leung is PI at the Beatson
Impact study in start up
Start Year 2018
 
Description The transcriptome of bone marrow and nasal polyp plasma cells. 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution I provided the RNA isolated from various bone marrow and nasal polyp cell population for microarray analysis
Collaborator Contribution Generated cDNA, labeled the the cDNA and hybridised onto a human genome U133 plus 2.0 array.
Impact None to report yet
Start Year 2018
 
Description Theragnostics Ltd (PROSPER Study) 
Organisation Theragenetics Ltd
Country United Kingdom 
Sector Private 
PI Contribution PI and research fellow running the trial
Collaborator Contribution Theragnostics Ltd have provided tracer FoC and have part funded a research fellow
Impact PROSPER Study in setup awaiting final R&D approval
Start Year 2018
 
Description Theragnostics Ltd collaboration in THP-PSMA PET imaging 
Organisation Theragnostics Limited
Country United Kingdom 
Sector Private 
PI Contribution PI and PhD student leading research
Collaborator Contribution Theragnostics have provided research funding and tracer kits
Impact Publications Training case file
Start Year 2018
 
Description University of Nottingham - Cardiotoxicity screening platform 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution We have been analysing cardiomyocyte data under different drug treatment regimens and have revealed altered characteristics in the shape of the contractility waveform which may increase the sensitivity of detecting cardiotoxic effects of new drugs in development.
Collaborator Contribution Provision of cardiomyocyte data
Impact Data is being collected for grant application. We have also discussed the data with the Health and Environmental Sciences Institute who partner with industry tobring technological advancements to drug efficacy and safety screening.
Start Year 2019
 
Title Identification of novel fungal peptide toxin activating epithelial cells 
Description Claims based around candidalysin, a 31 amino acid sequence in a Candida albicans hypha specific protein that acts as a cytolytic peptide toxin, together with antibodies and small molecules targeting candidalysin. 
IP Reference WO2014167335 
Protection Patent granted
Year Protection Granted 2019
Licensed No
Impact US Patent No.: 9,969,796, EU patent No: 984103. Applications pending in China (CN 201480033206.2) and USA (US 15/933,660)
 
Title LARA manual for mental health professionals 
Description This manual was developed in a stakeholder workshop and built on our previous work on domestic violence and abuse experienced by mental health service users. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2019
Licensed No
Impact Resource downloaded for use by NHS Mental Health Trusts and available on RCN WEBSITE
 
Title Galliprost (68Ga-TH-PSMA) 
Description Phase 2 trial complete. Phase 3 trial in preparation. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2019
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Publications 
 
Title Galliprost (68Ga-THP-PSMA) 
Description Evaluation of Prostate-Specific Membrane Antigen (68Ga) PET/CT as a tool to guide treatment choice in patients with high risk prostate cancer in progress 
Type Diagnostic Tool - Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2020
Development Status Closed
Clinical Trial? Yes
Impact Publications. Galliprost is in clinical use in several UK departments. A phase 2 trial is completed. A training case file has been formed for training for a phase 3 study. 
 
Title Electronic automatic screening tool to detect individuals at risk of psychosis in secondary mental health care 
Description An automatic risk calculator which is embedded with Electronic Health Records to screen large NHS databases and detect individuals who might be at risk of developing psychosis 
Type Of Technology Detection Devices 
Year Produced 2019 
Impact -The detection tool has attracteed industrial interest and a specific industry funded grant -The tool has been endorsed by a national (NIHR MH TRC EP Workstream) and international (ECNP TWG PMD-MHP) infrastructures -The tool is being used to support ongoing large-scale grant applications (EUNIA) 
URL http://psychosis-risk.net/
 
Title Gazele: Microscale Brain Network Dynamics 
Description Software package for the complete study, data manipulation and modelling of the dynamics and structure of complex brain networks. It requires zero knowledge of programming or scripting and consists of two standalone applications, Gazele and Coconi. 
Type Of Technology Webtool/Application 
Year Produced 2019 
Impact None yet as still undergoing release. 
 
Company Name NEUROGNOSTICS LTD 
Description Company aimed to provide services for the investigation of complicated neurological cases such as in the case of epilepsy. 
Year Established 2017 
Impact NA
 
Description Asthma UK Centre in Allergic Mechanisms of Asthma Science day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I gave a talk at the science day of Asthma UK Centre in Allergic Mechanisms of Asthma. The science day was organised by Imperial college and King's College London at St Mary's Campus, Imperial College.
Year(s) Of Engagement Activity 2019
 
Description A formal workshop with Healthy London Partnership and NHS England 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact A one-day workshop with NHS England and Healthy London Partnership to promote innovative models of care for young people with emerging mental disorders. The workshop is shaping the national strategy to implement the NHS Long Term Plans for early detection and treatment of mental disorders.
Year(s) Of Engagement Activity 2019
URL https://www.healthylondon.org
 
Description BioDynamics 2018: Dynamic network characterisation of icEEG interictal spike events in TLE patients may associate with surgical outcome (DS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Purpose
Microstructural EEG elements and their functional networks relate to many neurophysiological functions of the brain and may reveal abnormalities. The Interictal Epileptiform Discharge (IED), a hallmark graphoelement of epileptic EEG, is thought to play a key role in the formation and evolution of pathogenic networks in epilepsy. Although IEDs have previously been studied, their network attributes are still to be fully elucidated. Here, we perform a dynamic network characterisation of IEDs with high temporal selectivity, regarding this as a readily available window into the epileptic brain state.

Methods

Commonly, brain connectivity studies of epilepsy using  EEG analyse either entire recordings, including pathogenic but also normal brain activities, or lengthy rare events, such as epileptic seizures. For the first time here, we estimate pathogenic networks that characterise very brief IEDs lasting a few 10's of milliseconds, alone. We use an inverse power method for estimation of sparse principal component analysis in order to reveal connectivity properties that are consistent across subjects. Finally, we employ centrality measures (eg. betweenness, eigencentrality, closeness) to identify areas that are either influential or play an important role in the IED network function.

Results

In a preliminary analysis of four exemplar patients, we examined their first EEG at initial epilepsy onset; subsequently, two proved to be treatment-responsive and two were treatment-resistant. We show a difference in their network features. Specifically, IED networks differ in their modularity.

Conclusion

We conclude that network investigation of IEDs may reveal predictive biomarkers for early identification of treatment outcome.
Year(s) Of Engagement Activity 2018
 
Description Bioindustry Association Webinar: AI solutions for earlier disease detection 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invitation to give a webinar as part of International Women's Day for the Bioindustry Association. This gave me the opportunity to present the work to a wider audience within the Bioindustry sector.
Year(s) Of Engagement Activity 2019
URL https://www.youtube.com/watch?v=c4VJGlFDN-8
 
Description Biological Surfaces and Interfaces FEBS workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Around 160 international leading experts interested in biological surfaces gathered to discuss the latest development on the subject. I was selected among few early career researcher to give an oral presentation on my research followed by Q&A. This raised the awareness and interest of my work and future engagements with the conference organization.
Year(s) Of Engagement Activity 2017
URL https://mimeresearch.com/biointerfaces2017/
 
Description British Association of Urological Surgeons 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact British Association of Urological Surgeons
Lecture on state-of-the-art PET imaging in prostate cancer and update on PROSPER Study
Year(s) Of Engagement Activity 2018
 
Description British Society of Allergy and Clinical Immunology Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The organising commute of the BSACI 2019 conference invited me to give a talk at the 2019 conference held in Harrogate, UK. My talk was in the session called "What is new in IgE?". The invitation to give a talk at the conference was made to replace another speaker that had to pull out of the conference. This was after the final program was printed.
Year(s) Of Engagement Activity 2019
URL https://bsacimeeting.org
 
Description Computational Biomarkers in Early Identification and Prediction of Intractable Epilepsy (DS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Purpose
Microstructural EEG elements and their functional networks relate to many neurophysiological functions of the brain and may reveal abnormalities. The Interictal Epileptiform Discharge (IED), a hallmark graphoelement of epileptic EEG, is thought to play a key role in the formation and evolution of pathogenic networks in epilepsy. Although IEDs have previously been studied, their network attributes are still to be fully elucidated. Here, we perform a dynamic network characterisation of IEDs with high temporal selectivity, regarding this as a readily available window into the epileptic brain state.

Methods

Commonly, brain connectivity studies of epilepsy using EEG analyse either entire recordings, including pathogenic but also normal brain activities, or lengthy rare events, such as epileptic seizures. For the first time here, we estimate pathogenic networks that characterise very brief IEDs lasting a few 10's of milliseconds, alone. We use an inverse power method for estimation of sparse principal component analysis in order to reveal connectivity properties that are consistent across subjects. Finally, we employ centrality measures (eg. betweenness, eigencentrality, closeness) to identify areas that are either influential or play an important role in the IED network function.

Results

In a preliminary analysis of four exemplar patients, we examined their first EEG at initial epilepsy onset; subsequently, two proved to be treatment-responsive and two were treatment-resistant. We show a difference in their network features. Specifically, IED networks differ in their modularity.

Conclusion

We conclude that network investigation of IEDs may reveal predictive biomarkers for early identification of treatment outcome.
Year(s) Of Engagement Activity 2018
 
Description Eureka Blog for Charles River Labs: 'Big Data is all around us, but we're not using it...' 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact This science blog was written as part of the Eureka Series by Charles River Labs - an international CRO leading in medicines efficacy and safety assessment. This showcased a pilot project that we undertook with the company.
Year(s) Of Engagement Activity 2019
URL https://eureka.criver.com/big-data-is-all-around-us-but-were-not-using-it/
 
Description Europhysiology 2018: Lunchtime lecture: Maths in medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lunchtime lecture at Europhysiology 2018 -international physiology conference. This led to a number of research questions and publicised the method to a wider audience.
Year(s) Of Engagement Activity 2018
URL https://static.physoc.org/app/uploads/2019/03/22193716/Europhysiology-2018-PROG-ONLINE.pdf
 
Description Featured Scientist: ADInstruments Science Heroes 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was featured as part of the 'Science Heroes' campaign by ADInstruments - showcasing physiology research to a wider audience. This video has been shared widely and has been a useful way to publicise the method to support research collaboration and commercialization discussions.
Year(s) Of Engagement Activity 2018
URL https://www.adinstruments.com/manasi-nandi
 
Description Fungal infections - Poland Press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview with local journalist and article published in local Press
Year(s) Of Engagement Activity 2018
 
Description Heads Up 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Faculty organised a showcase of artistic collaborations leading to performances and work of art. Our group exhibited artwork generated from our research. The exhibit was open for 1 month in the Gallery at Bush House, and was visited by the general public, students and staff from King's.
Year(s) Of Engagement Activity 2019
 
Description Invited talk: Addenbrookes Hospital and Cambridge University Cardiovascular Centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Clinicians and academic researchers attended this lecture. As a result, i have established a number of ongoing collaborations. In particular, links with Addenbrookes hospital from where we will be able to access patient data for proof of concept studies about the utility of the mathematical method.
Year(s) Of Engagement Activity 2018
 
Description Keynote presentation: British Heart Foundation/NC3R Cardiovascular Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote presentation at BHF/NC3R showcase describing our mathematical method and application to the earlier detection of disease or drug effects. This talk led to new collaborations from both academic and industry labs which are ongoing.
Year(s) Of Engagement Activity 2018
URL https://nc3rs.org.uk/events/nc3rs-cardiovascular-showcase-event
 
Description Keynote: Dx Toxicology: Strategies for Success in Discovery and Development 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote lecture describing our research and its applications to drug discovery. This led to a number of questions and valuable feedback.
Year(s) Of Engagement Activity 2019
URL https://www.apconix.com/symposium-dx-toxicology-strategies-for-success-in-discovery-and-development/
 
Description Keynote: Eurotoxicology meeting 2018: Health and Environmental Sciences Institute CITE lecturer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Nominated as the HESI-CITE (Combining Interdisciplinary and Translational Expertise) lecturer. Audience consisted primarily of industry and academic scientists working in the field of drug safety assessment. This led to a number of questions and new industry collaborations and interaction with key opinion leaders in this field.
Year(s) Of Engagement Activity 2018
URL http://www.eurotox-congress.com/2018/?s=detailed-programmeClone
 
Description LARA-VP workshop (Addressing domestic violence in mental health services) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact We held a workshop on the information mental health practitioners need in order to respond to domestic violence victimisation and perpetration safely. A draft contents of a potential manual for mental health services was provided for the participants to comment on and presentations were given on current evidence base. The workshop was attended by safeguarding nurses, directors of nursing, chief executives of domestic violence charities, senior practitioners at number of different mental health trusts, policymakers at the Department of Health and Social Care, academics and mental health service users. There was agreement that an up-to-date valuable would be helpful for mental health trusts and the lead for domestic violence at the Department of Health and Social Care agreed to disseminated to all mental health trusts. NHS Improvement and the CQC have also expressed interest and details of the manual have been widely disseminated within our own organisation e.g. King's Health Partners newsletter, NHS England, CQC, DHSC etc.
Year(s) Of Engagement Activity 2018
URL https://www.kcl.ac.uk/ioppn/depts/hspr/research/ceph/wmh/lara-vp-download-form
 
Description Meeting with NHS England (Heather Caudle, Director of Nursing for Improvement) to discuss LARA-VP intervention 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact This meeting was set-up in order for Louise Howard and Emma Yapp to explain the LARA intervention, both in terms of the pilot intervention and current progress, to Heather Caudle, Director of Nursing for Improvement at NHS England. Heather Caudle expressed concern about overall lack of identification of domestic violence within mental health services, and about the failure of nurses in both primary and secondary care to assist in this practice. LH stressed the importance of working with the domestic violence sector in delivering interventions, and summarised the LARA pilot, leading to further discussion of improved the response to domestic violence within nursing. Louise Howard and Emma Yapp to attend next meeting of Strategic Leads recently set up across the Home Office, DoH and the NHS.
Year(s) Of Engagement Activity 2018
 
Description MyCoL 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The aim is to enable the fungal community (e.g. researchers, academics, clinicians, podiatrists, etc) in London to get together on a regular basis to discuss their work and exchange ideas, in order to facilitate research collaborations, apply for funding, promote student exchanges and undertake public engagement activities.
Year(s) Of Engagement Activity 2020
URL https://www.eventbrite.co.uk/e/mycol-mycology-community-of-london-second-meeting-tickets-97717645107...
 
Description Patient group workshop " Discover Science through Art" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact This activity was to relate our MRC funded research to patients through art. After describing our work and hosting a lab visit the patients were taught to express their understanding of the research in art. The designs they achieved were then printed into scarves that each patients could keep.
The patients really enjoyed the workshop and the interaction with the scientist. To quote one patient " I just wanted to reiterate how much I enjoyed Tuesday's workshop, I absolutely believe that it's such a great thg for both patients and researchers to have more interaction with each other"
Moreover this workshop really allowed patients to understand our research as exemplified by the quote 'Cells are so influenced by the environment, aren't they?'
Year(s) Of Engagement Activity 2019
URL https://twitter.com/SweetBiology
 
Description Public engagement - Soapbox Science, Brighton 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Soapbox science in a national public outreach platform for promoting women scientists and their work. I co-presented our mathematical method and its application to health care with the post doc who was employed by the KHP R&D challenge fund (MRC confidence in concept award). This took place on a soapbox on Brighton beach and members of the public were able to gather and listen to the different speakers. Questions spanned from the value of big data in healthcare to how our work may help patients in critical care. Through this exhibition, i was contacted by a lead for STEM girls club and have since participated in a number of school events around STEM including a career workshop about STEM subjects and a further schools talk about the work we do.
Year(s) Of Engagement Activity 2018
URL http://soapboxscience.org/soapbox-science-2018-brighton/
 
Description Visit of CRUK donors 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Visit by donors to CRUK. Our MRC funded research was describe by myself and the members of the lab showed the participants some simple experiments.
Year(s) Of Engagement Activity 2018
 
Description Workshop on CyTOF 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Together with Jo Spencer and Susanne Heck we organised a workshop on solid cyTOF to introduce the technique and its potentials to the broader audience of research groups at KCL. The event was organised in collaboration with the Cancer Research UK KHP Centre and the Quantitative Genomics Programme of the School of Cancer and Pharmaceutical Sciences at King's College London.
Year(s) Of Engagement Activity 2017