The Innovative Targets Portfolio: Basic Life Sciences Research to Novel Therapies, through a Portfolio of Small Molecule Translational Projects (CiC 2017)
Lead Research Organisation:
University of Dundee
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Publications
Petit AP
(2018)
A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot.
in The Journal of biological chemistry
| Description | Defining the role of PKN2 in cancer-associated fibroblasts |
| Amount | £99,773 (GBP) |
| Funding ID | SBF001\1004 |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2016 |
| End | 08/2019 |
| Description | Development of a novel treatment for pancreatic cancer by targeting normal cells within the pancreas, which help cancer to develop |
| Amount | £24,000 (GBP) |
| Funding ID | M483 |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2019 |
| Description | Discovery of specific inhibitors of the cellular response to interferon |
| Amount | £50,000 (GBP) |
| Organisation | Newcastle University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 12/2018 |
| Description | tau seeding collaboration with Takeda |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | DDU screened an assay deriveing 6 series of novel chemotypes. The chemotypes were expanded using medicinal chamistry to show cell based activity in parallel with good CNS penetration and DMPK properties. The DDU will move these series forward to idnetify targets and deliver compounds ready for pre-candidate selection. |
| Collaborator Contribution | Partners provided a screening assay for interrogating tau seeding. Partners will support profiling of molecules in secondary assays and, if appropriate, in animal models of disease. |
| Impact | None as yet |
| Start Year | 2019 |
| Description | tau seeding collaboration with Takeda |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | DDU screened an assay deriveing 6 series of novel chemotypes. The chemotypes were expanded using medicinal chamistry to show cell based activity in parallel with good CNS penetration and DMPK properties. The DDU will move these series forward to idnetify targets and deliver compounds ready for pre-candidate selection. |
| Collaborator Contribution | Partners provided a screening assay for interrogating tau seeding. Partners will support profiling of molecules in secondary assays and, if appropriate, in animal models of disease. |
| Impact | None as yet |
| Start Year | 2019 |