Imperial Confidence in Concept: ICIC6

Lead Research Organisation: Imperial College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Allegretti JR (2020) Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients. in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

 
Title ICiC 6 - Picinali - BEARS applications prototypes video 
Description Video created from PPI event organised within the project. 
Type Of Art Film/Video/Animation 
Year Produced 2019 
Impact No notable impact up to now, except for a generally higher visibility for the project. 
URL https://www.youtube.com/watch?v=cvPReMtBGlk&t=100s
 
Title ICiC 6 - Picinali - Developing the BEARs virtual reality training package (short version) 
Description Video created from PPI events organised within the project. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact No notable impact up to now, except for a generally higher visibility for the project. 
URL https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s
 
Title ICiC 6 - Picinali - Hearing devices for music listening 
Description Video created from PPI events organised within the project. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact No notable impact up to now, except for a generally higher visibility for the project. 
URL https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s
 
Description ICiC 6 - Edwards - MRC Centre for Molecular Bacteriology and Infection - Studentship
Amount £96,400 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 03/2023
 
Description ICiC 6 - Isalan - BBSRC DTP PhD studentship
Amount £80,726 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description ICiC 6 - Mann - Selective irreversible allosteric inhibition of MCL-1 to potentiate apoptosis in sarcomas
Amount £119,873 (GBP)
Organisation Sarcoma UK 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2020 
End 08/2023
 
Description ICiC 6 - Matthews - MRC project grant (MR/S021191/1)
Amount £650,000 (GBP)
Funding ID MR/S021191/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2019 
End 06/2022
 
Description ICiC 6 - Picinali - William Demant Foundation grant
Amount £350,000 (GBP)
Funding ID NDAA P79471 
Organisation William Demant Holding Group 
Sector Private
Country Denmark
Start 06/2019 
End 05/2022
 
Description ICiC 6 - Scott - Capital Award Emphasising Support for Early Career Researchers, EPSRC Internal Scheme
Amount £98,373 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 03/2020
 
Description ICiC 6 - Tate - Imperial College London Institute of Chemical Biology CDT MRes/PhD studentship.
Amount £125,000 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 09/2022
 
Description ICiC 6 - Tate - Imperial College London President's PhD Scholarship.
Amount £181,000 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 09/2019 
End 09/2023
 
Description ICiC 6 - Tate - Small Molecule Drug Discovery Project Award
Amount £313,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2022
 
Title ICiC 6 - Bentley - Automated quantification of clinically-relevant features on brain CT 
Description We have developed imaging analytic software allowing for rapid, automated quantification of features on brain CT that facilitate management decisions. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? Yes  
Impact Our method has been cited by an influential Government report, as an example of cost-effective medical AI technology that can improve clinical decision making and improved healthcare outcomes (Chief Medical Officer 2018). 
 
Title ICiC 6 - O'Hare - Clickable viruses 
Description This tool is a modified virus containing small chemical tags in its structural proteins. Such tags will provide extremely useful and versatile in many fields, but especially for the project here, in the field of novel vaccines. The aim, partly validated, is to tag these new virus particles in a completely specific manner, with desirable adducts that will inactivate infectivity while persevering immunogenicity 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact None yet. 
 
Title ICiC 6 - Tate - Covalent fragment ligands for Rab27a 
Description A total of 56 derivatives from Series A and Series B have been synthesised, leading to an improvement in the REF for labelling Rab27a up to 140x compared to glutathione. These molecules are the starting points for on-going ligand growth/elaboration work either through secondary screening or PROTAC development. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact The successful development of these tools has been a substantial factor in securing follow-on funding and studentships to continue the project beyond the duration of the current Imperial Confidence in Concept award. 
 
Title ICiC 6 - Tate - Methods for assessing reaction between covalent fragments and target molecules. 
Description New methods have been developed to assess the rate of covalent modification of a protein using a fluorescence anisotropy readout (rather than fluorescence intensity in the original QIT assay). This new method allows from more sensitive detection of labelling in more dilute protein samples. Secondary confirmation assays (intact protein mass spectrometry, peptide mass fingerprinting, differential scanning fluorimetry) have also been integrated into the QIT screen. These methods have allowed assessment of newly synthesised ligands at lower concentrations which are closer to those required for cellular assays. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact These methods have allowed assessment of newly synthesised ligands at lower concentrations which are closer to those required for cellular assays and allowed for a more streamline and robust analysis of ligands. The development of these methods has been key in demonstrating the quality of our ligands and supporting future development of improved ligands, an important factor in securing follow-on funding 
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation Northwick Park Hospital
Department Stroke services
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation St Bartholomew's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation St Georges Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University College London Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation William Harvey Hospital Kent
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases.
Start Year 2014
 
Description ICiC 6 - Blagborough - Field-Assessment of Novel Native GPI-Anchored-Protein Based Anti-Malarial Vaccines 
Organisation Institute of Research in Health Sciences
Country Burkina Faso 
Sector Public 
PI Contribution Coordination of experimental planning, support in writing grant applications and coordination of experimental activities.
Collaborator Contribution Support in writing grant applications and coordination of experimental activities.
Impact 1. Multiple grant applications to MRC, currently awaiting outcome 2. Award of Alborada Trust Grant to both collaborators to continue research. 3. Successful Stage 1 application to NIHR
Start Year 2018
 
Description ICiC 6 - Clarke - Probiotic approaches to combat antibiotic associated diarrhea and enteric infection 
Organisation Nestlé UK
Country United Kingdom 
Sector Private 
PI Contribution We will supervise a PhD student.
Collaborator Contribution Provided funding for PhD student
Impact None as yet.
Start Year 2018
 
Description ICiC 6 - Edwards - ICiC partnership 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution We developed tools for drug screening to discover new antibacterial molecules.
Collaborator Contribution They provided expertise, facilities and a compound library for the screening.
Impact None yet
Start Year 2019
 
Description ICiC 6 - Larrouy-Maumus - Colistin resistant at Imperial NHS Trust 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide access to MALDxin and expertise in lipidomics (Department of Life Sciences)
Collaborator Contribution Provide clinical isolates and expertise in infectious diseases (NHLI and Department of Infectios Disease [formally Department of Medicine])
Impact No outputs so far. Clinical and basic science collaborators.
Start Year 2019
 
Description ICiC 6 - Larrouy-Maumus - Colistin resistant at Imperial NHS Trust 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide access to MALDxin and expertise in lipidomics (Department of Life Sciences)
Collaborator Contribution Provide clinical isolates and expertise in infectious diseases (NHLI and Department of Infectios Disease [formally Department of Medicine])
Impact No outputs so far. Clinical and basic science collaborators.
Start Year 2019
 
Description ICiC 6 - Larrouy-Maumus - Colistin resistant at Imperial NHS Trust 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide access to MALDxin and expertise in lipidomics (Department of Life Sciences)
Collaborator Contribution Provide clinical isolates and expertise in infectious diseases (NHLI and Department of Infectios Disease [formally Department of Medicine])
Impact No outputs so far. Clinical and basic science collaborators.
Start Year 2019
 
Description ICiC 6 - Marchesi - Bile salt hydrolase and valerate: novel treatments to prevent and treat Clostridium difficile infection 
Organisation Brigham and Women's Hospital
Country United States 
Sector Hospitals 
PI Contribution We provided metabolic profiling expertise
Collaborator Contribution Both partners provided biological samples that we analysed using our metabolic profiling expertise
Impact 3 papers have been published:- Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR. Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print] PMID: 30816855 Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. Allegretti JR, Kassam Z, Carrellas M, Mullish BH, Marchesi JR, Pechlivanis A, Smith M, Gerardin Y, Timberlake S, Pratt DS, Korzenik JR. Am J Gastroenterol. 2019 Jan 31. doi: 10.14309/ajg.0000000000000115. [Epub ahead of print] PMID: 30730351 Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota. McDonald JAK, Mullish BH, Pechlivanis A, Liu Z, Brignardello J, Kao D, Holmes E, Li JV, Clarke TB, Thursz MR, Marchesi JR. Gastroenterology. 2018 Nov;155(5):1495-1507.e15. doi: 10.1053/j.gastro.2018.07.014. Epub 2018 Jul 17. PMID: 30025704
Start Year 2015
 
Description ICiC 6 - Marchesi - Bile salt hydrolase and valerate: novel treatments to prevent and treat Clostridium difficile infection 
Organisation University of Alberta
Country Canada 
Sector Academic/University 
PI Contribution We provided metabolic profiling expertise
Collaborator Contribution Both partners provided biological samples that we analysed using our metabolic profiling expertise
Impact 3 papers have been published:- Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR. Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print] PMID: 30816855 Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. Allegretti JR, Kassam Z, Carrellas M, Mullish BH, Marchesi JR, Pechlivanis A, Smith M, Gerardin Y, Timberlake S, Pratt DS, Korzenik JR. Am J Gastroenterol. 2019 Jan 31. doi: 10.14309/ajg.0000000000000115. [Epub ahead of print] PMID: 30730351 Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota. McDonald JAK, Mullish BH, Pechlivanis A, Liu Z, Brignardello J, Kao D, Holmes E, Li JV, Clarke TB, Thursz MR, Marchesi JR. Gastroenterology. 2018 Nov;155(5):1495-1507.e15. doi: 10.1053/j.gastro.2018.07.014. Epub 2018 Jul 17. PMID: 30025704
Start Year 2015
 
Description ICiC 6 - Matthews - Medicinal Chemistry Collaborations - Prof Brennan (Oxford) 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide chemical lead hits for derivitisation
Collaborator Contribution Chemistry of bound hits to provide an expanded library. Using fragment screening experience background to contribute to the choice of fragments used in the second round of XChem fragment screening
Impact N/A
Start Year 2019
 
Description ICiC 6 - Matthews - Medicinal Chemistry Collaborations - Prof Tate's group (Imperial Chemistry Department) 
Organisation Imperial College London
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide chemical lead hits for derivitisation
Collaborator Contribution Chemistry of bound hits to provide an expanded library. Their experience in small molecule design will be utilised to develop initial hits found from XChem screens
Impact None as yet
Start Year 2019
 
Description ICiC 6 - McKay - Optimization of Modular, Exteriorly-Loaded Lipid Nanoparticles for mRNA Delivery in Human Skin Explants 
Organisation AstraZeneca
Department Pharmaceutical Technology & Development
Country United Kingdom 
Sector Private 
PI Contribution We prepare formulations and test for stability, in vitro and in vivo efficacy.
Collaborator Contribution They provide components of the materials as well as expertise in certain applications for the formulations.
Impact This collaboration has resulted in generation of data but no formal outputs to date. It is multidisciplinary; AstraZeneca: pharmaceutical development, Imperial College: formulation science, immunology, vaccinology
Start Year 2018
 
Description ICiC 6 - Overby - A collaboration between a bioengineer and a cancer doctor. 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution The engineer aims to design a device to take a biopsy specimen from a tumour (provided by the cancer doctor) and put the biopsy specimen within a microfluidics device. The goal is to maintain the viability of the specimen ex vivo for cancer screening applications. Viability is accomplished via perfusion of nutrient-containing medium through the specimen. We (Department of Bioengineering) have developed the research programme, designed the experiments to test the hypothesis and designed the device that allows us to do this.
Collaborator Contribution They (Department of Surgery & Cancer) have provided tumour biopsy material. We are currently using material from mice, but will be beginning to include material from human patients.
Impact We are currently gathering data necessary to for publication and IP disclosure. Collaboration is multi-disciplinary. Bioengineer and a clinician specilaising in cancer.
Start Year 2018
 
Description ICiC 6 - Overby - A collaboration between a bioengineer and a cancer doctor. 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution The engineer aims to design a device to take a biopsy specimen from a tumour (provided by the cancer doctor) and put the biopsy specimen within a microfluidics device. The goal is to maintain the viability of the specimen ex vivo for cancer screening applications. Viability is accomplished via perfusion of nutrient-containing medium through the specimen. We (Department of Bioengineering) have developed the research programme, designed the experiments to test the hypothesis and designed the device that allows us to do this.
Collaborator Contribution They (Department of Surgery & Cancer) have provided tumour biopsy material. We are currently using material from mice, but will be beginning to include material from human patients.
Impact We are currently gathering data necessary to for publication and IP disclosure. Collaboration is multi-disciplinary. Bioengineer and a clinician specilaising in cancer.
Start Year 2018
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation Guy's and St Thomas' NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grand writing.
Collaborator Contribution support in writing grant application, coordination in grand writing.
Impact Successful proposal, research funded by the William Demant Foundation, project started in June 2019
Start Year 2018
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing
Impact Submission of an EPSRC responsive mode proposal (submitted 30th of January 2020)
Start Year 2018
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing
Impact Submission of an EPSRC responsive mode proposal (submitted 30th of January 2020)
Start Year 2018
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing
Impact Submission of an EPSRC responsive mode proposal (submitted 30th of January 2020)
Start Year 2018
 
Description ICiC 6 - Rodriguez y Baena - Imperial College London and Oxford Optronix Ltd. SHINE collaboration 
Organisation Oxford Optronix Ltd
Country United Kingdom 
Sector Private 
PI Contribution The team from Imperial College London contributes in the development of the vessel detection and reconstruction method and subsequent avoidance strategy using Programmable Bevel-tip Steerable Needle system. The method will be based on the measurements of a laser Doppler flowmetry (LDF) monitor that is developed by Oxford Optronix Ltd.
Collaborator Contribution Since no commercial LDF monitor is suitable for the purpose of the SHINE project, Oxford Optronix is providing an upgraded version of their commercial, four-channel LDF system. This upgrade includes the ability to 'gate' reading from each channel, increased dynamic range in support of higher blood flow velocity, and a new type of LDF probe.
Impact Currently, there is no outcome yet.
Start Year 2018
 
Description ICiC 6 - Tate - Access to the XChem Fragment Screening Platform at the Diamond Light Source 
Organisation Diamond Light Source
Country United Kingdom 
Sector Private 
PI Contribution Identification of hit ligands, production of purified recombinant protein, and production of protein crystals labelled with hit ligand for screening on the XChem platform.
Collaborator Contribution 1. Diamond Light Source has given access to the XChem screening platform, training and supervision for users, access to beamtime on I04-1 to collect data. 2. Protein Crystallography Facility at Imperial has provided training and supervision on the XChem screening platform, performing of XChem screen, assistance and training in data collection and analysis.
Impact Identification of a new non-covalent fragment that binds to target protein (termed X01) labelled with the B01 ligand. The BAG proposal for beam time between April and October 2019 was successful and will allow a further 1-2 rounds of XChem fragment screening to grow existing covalent ligands. Collaboration is multi-disciplinary between organic chemical synthesis, biochemistry, and structural biology.
Start Year 2018
 
Description ICiC 6 - Tate - Access to the XChem Fragment Screening Platform at the Diamond Light Source 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification of hit ligands, production of purified recombinant protein, and production of protein crystals labelled with hit ligand for screening on the XChem platform.
Collaborator Contribution 1. Diamond Light Source has given access to the XChem screening platform, training and supervision for users, access to beamtime on I04-1 to collect data. 2. Protein Crystallography Facility at Imperial has provided training and supervision on the XChem screening platform, performing of XChem screen, assistance and training in data collection and analysis.
Impact Identification of a new non-covalent fragment that binds to target protein (termed X01) labelled with the B01 ligand. The BAG proposal for beam time between April and October 2019 was successful and will allow a further 1-2 rounds of XChem fragment screening to grow existing covalent ligands. Collaboration is multi-disciplinary between organic chemical synthesis, biochemistry, and structural biology.
Start Year 2018
 
Description ICiC 6 - Wigneshweraraj - Host environment dependent delivery of antibacterials by engineered phage 
Organisation Jichi Medical University
Country Japan 
Sector Academic/University 
PI Contribution Imperial: Resources
Collaborator Contribution School of Medicine, Jichi Medical University, Japan: Training and resources
Impact N/A
Start Year 2018
 
Title USE OF AXL, CCL19 AND/OR BMP-6 FOR PROMOTING WOUND HEALING 
Description The invention relates to the treatment of a wound, and in particular to uses of polypeptides (or genetic constructs or vectors encoding such peptides) to promote wound healing and/or reduce, prevent or inhibit scarring. The invention extends to pharmaceutical compositions comprising such polypeptides or constructs, for treating wounds, and for reducing scarring, and cosmetic formulations for improving the appearance of skin. The invention also extends to wound dressings, formulations and bandages comprising such polypeptides. 
IP Reference WO2019180419 
Protection Patent application published
Year Protection Granted 2019
Licensed No
Impact Helena Topouzi, co-inventor on the patent has secured 3 months funding to be a techcelerate fellow at Imperial College. We have started a collaboration with Dr Kyle Quinn, to evaluate the efficacy of sAXL in murine wounds in vivo.
 
Title ICiC 6 - Rodriguez - LDF for Deep Brain Vessel Detection 
Description In the next seven months, we will perform animal trials to optimise the performance of the vessel detection system developed in this Confidence in Concept. Together with the programmable bevel-tip needle that has been developed in the EDEN2020 project. 
Type Support Tool - For Medical Intervention
Current Stage Of Development Initial development
Year Development Stage Completed 2020
Development Status Under active development/distribution
Impact The device is still under development. 
 
Title ICiC 6 - Rodriguez Y Baena - Vessel Detection method using a steerable needle system 
Description A laser Doppler flowmetry sensor is embedded within each segment of a programmable bevel-tip needle to detect a blood vessel. A type of machine learning network was used to interpret sensor data. Using this method, information with regards to vessel size and pose can be extracted. 
Type Of Technology Detection Devices 
Year Produced 2018 
Impact A programmable bevel-tip needle embedded with optical sensors to detect and predict vessel pose in front of it can be used to perform haemorrhage free intervention. This method is useful for minimally invasive brain surgery since haemorrhage during this procedure can be life-threatening. 
 
Description ICiC 6 - Blagborough - Cambridge Science Festival and Imperial Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 300 people attended multiple events designed to showcase our research - engagement sparked multiple questions and discussion, with multiple requests for people to attend and get involved with the research in the future.
Year(s) Of Engagement Activity 2017,2018,2019,2020
 
Description ICiC 6 - Edwards - Great exhibition Rd festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact >2000 people visited the infection zone at the festival. We used a variety of games and props to explain the work, including a 'DNA repair Jenga' game. This led to questions and discussions about our work from members of the public.
Year(s) Of Engagement Activity 2019
 
Description ICiC 6 - Larrouy-Maumus - Imperial College Alumni 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Generate enthusiasm in infectious diseases and awareness on the growing concern of AMR
Year(s) Of Engagement Activity 2019
URL https://www.imperial.ac.uk/news/194088/thank-from-professor-tom-welton-dean/
 
Description ICiC 6 - Larrouy-Maumus - Imperial College Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Generate enthusiasm in infectious diseases and awareness on the growing concern of antimicrobial resistance
Year(s) Of Engagement Activity 2019
 
Description ICiC 6 - Marchesi - BBC Radio 5 discussion 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Discussion of the gut microbiome
Year(s) Of Engagement Activity 2019
 
Description ICiC 6 - Marchesi - Tortoise ThinkIn - Go with your gut - Discussion 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact General discussion of the gut and gut microbiota, with a Q and A
Year(s) Of Engagement Activity 2019
URL https://www.youtube.com/watch?v=31wE_TD_vqI&feature=youtu.be
 
Description ICiC 6 - Matthews - School talk at Harris Academy St John's Wood 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Talk about research field at local school
Year(s) Of Engagement Activity 2019
 
Description ICiC 6 - McKay - Optimization of Modular, Exteriorly-Loaded Lipid Nanoparticles for mRNA Delivery in Human Skin Explants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 20 pupils attended an after-school science club to participate in a hands-on outreach activity and learn about preparing vaccines in the event of an outbreak.
Year(s) Of Engagement Activity 2018,2019
 
Description ICiC 6 - Picinali - Evaluating the BEARS package 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Evaluating the BEARS package. This was the final event of the PPI work carried out with teenager bilateral cochlear implantees.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s
 
Description ICiC 6 - Picinali - Hearing Futures II (in collaboration with the V&A Museum). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact • Hearing Futures II (in collaboration with the V&A Museum). This was an event organised to explore the need for additional research in the area of hearing assistive devices and music listening. This event fostered further networking activities, which brough to a further workshop held at Imperial College in January 2019, and consequent work for funding applications (EPSRC - Music and Hearing Impairment)
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s
 
Description ICiC 6 - Rodriguez - The Great Exhibition Road Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact During the Great Exhibition Road Festival, we presented a simulation of a steerable needle with a vessel avoidance system. In the simulation, audiences controlled the movement of the needle with a joystick, which emulates a pc game. This format of presentation attracted many children to try. After they played the 'game', we then explained how the system works.
Year(s) Of Engagement Activity 2019
URL https://www.imperial.ac.uk/news/191848/eden2020-the-great-exhibition-road-festival/
 
Description ICiC6 - Stevens - Presentation at SPIE conference (Jelle Penders) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Jelle Penders presented at SPIE Photonics West (The International Society for Optics and Photonics) conference in San Francisco, relevant to this project.
Year(s) Of Engagement Activity 2019
 
Description IiC 6 - Marchesi - Interview for TV as gut expert 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Short interview on gut health and the impact of eating junk food
Year(s) Of Engagement Activity 2018,2019