Imperial Confidence in Concept: ICIC6

Lead Research Organisation: Imperial College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Allegretti JR (2019) Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients. in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

 
Title ICiC 6 - Picinali - Developing the BEARs virtual reality training package (short version) 
Description video we created from two separate PPI events organised within the project. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact No notable impact up to now, except for a generally higher visibility for the project. 
URL https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s
 
Title ICiC 6 - Picinali - Hearing devices for music listening 
Description Video we created from two separate PPI events organised within the project. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact No notable impact up to now, except for a generally higher visibility for the project. 
URL https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s
 
Description ICiC 6 - Clarke - PhD studentship from industrial sponsor
Amount £100,000 (GBP)
Organisation Nestlé UK 
Start 10/2019 
End 10/2022
 
Description ICiC 6 - Isalan - BBSRC DTP PhD studentship
Amount £30,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description ICiC 6 - Matthews - MRC project grant (MR/S021191/1)
Amount £650,000 (GBP)
Funding ID MR/S021191/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2019 
End 06/2022
 
Description ICiC 6 - Scott - Capital Award Emphasising Support for Early Career Researchers, EPSRC Internal Scheme
Amount £98,373 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 03/2020
 
Description ICiC 6 - Tate - Imperial College London Institute of Chemical Biology CDT MRes/PhD studentship.
Amount £125,000 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 09/2022
 
Description ICiC 6 - Tate - Imperial College London President's PhD Scholarship.
Amount £181,000 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 09/2019 
End 09/2023
 
Description ICiC 6 - Tate - Small Molecule Drug Discovery Project Award
Amount £313,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2022
 
Title ICiC 6 - Bentley - Automated quantification of clinically-relevant features on brain CT 
Description We have developed imaging analytic software allowing for rapid, automated quantification of features on brain CT that facilitate management decisions. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? Yes  
Impact Our method has been cited by an influential Government report, as an example of cost-effective medical AI technology that can improve clinical decision making and improved healthcare outcomes (Chief Medical Officer 2018). 
 
Title ICiC 6 - O'Hare - Clickable viruses 
Description This tool is a modified virus containing small chemical tags in its structural proteins. Such tags will provide extremely useful and versatile in many fields, but especially for the project here, in the field of novel vaccines. The aim, partly validated, is to tag these new virus particles in a completely specific manner, with desirable adducts that will inactivate infectivity while persevering immunogenicity 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact None yet. 
 
Title ICiC 6 - Tate - Covalent fragment ligands for Rab27a 
Description A total of 56 derivatives from Series A and Series B have been synthesised, leading to an improvement in the REF for labelling Rab27a up to 140x compared to glutathione. These molecules are the starting points for on-going ligand growth/elaboration work either through secondary screening or PROTAC development. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact The successful development of these tools has been a substantial factor in securing follow-on funding and studentships to continue the project beyond the duration of the current Imperial Confidence in Concept award. 
 
Title ICiC 6 - Tate - Methods for assessing reaction between covalent fragments and target molecules. 
Description New methods have been developed to assess the rate of covalent modification of a protein using a fluorescence anisotropy readout (rather than fluorescence intensity in the original QIT assay). This new method allows from more sensitive detection of labelling in more dilute protein samples. Secondary confirmation assays (intact protein mass spectrometry, peptide mass fingerprinting, differential scanning fluorimetry) have also been integrated into the QIT screen. These methods have allowed assessment of newly synthesised ligands at lower concentrations which are closer to those required for cellular assays. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact These methods have allowed assessment of newly synthesised ligands at lower concentrations which are closer to those required for cellular assays and allowed for a more streamline and robust analysis of ligands. The development of these methods has been key in demonstrating the quality of our ligands and supporting future development of improved ligands, an important factor in securing follow-on funding 
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation Imperial College Healthcare NHS Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation Northwick Park Hospital
Department Stroke services
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation St Bartholomew's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation St Georges Hospital
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University College London Hospital
Country United Kingdom 
Sector Public 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Bentley - NIHR CRN stroke 
Organisation William Harvey Hospital Kent
Country United Kingdom 
Sector Hospitals 
PI Contribution Partner organisations are provided with administrative costs and credit for research accruals by NIHR
Collaborator Contribution Identification, extraction, collation of imaging and clinical data
Impact Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT
Start Year 2014
 
Description ICiC 6 - Blagborough - Field-Assessment of Novel Native GPI-Anchored-Protein Based Anti-Malarial Vaccines 
Organisation Institute of Research in Health Sciences
Country Burkina Faso 
Sector Public 
PI Contribution Coordination of experimental planning, support in writing grant applications and coordination of experimental activities.
Collaborator Contribution Support in writing grant applications and coordination of experimental activities.
Impact Successful Stage 1 application to NIHR
Start Year 2018
 
Description ICiC 6 - Clarke - Probiotic approaches to combat antibiotic associated diarrhea and enteric infection 
Organisation Nestlé UK
PI Contribution We will supervise a PhD student.
Collaborator Contribution Provided funding for PhD student
Impact None as yet.
Start Year 2018
 
Description ICiC 6 - Marchesi - Bile salt hydrolase and valerate: novel treatments to prevent and treat Clostridium difficile infection 
Organisation Brigham and Women's Hospital
Country United States 
Sector Hospitals 
PI Contribution We provided metabolic profiling expertise
Collaborator Contribution Both partners provided biological samples that we analysed using our metabolic profiling expertise
Impact 3 papers have been published:- Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR. Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print] PMID: 30816855 Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. Allegretti JR, Kassam Z, Carrellas M, Mullish BH, Marchesi JR, Pechlivanis A, Smith M, Gerardin Y, Timberlake S, Pratt DS, Korzenik JR. Am J Gastroenterol. 2019 Jan 31. doi: 10.14309/ajg.0000000000000115. [Epub ahead of print] PMID: 30730351
Start Year 2015
 
Description ICiC 6 - Marchesi - Bile salt hydrolase and valerate: novel treatments to prevent and treat Clostridium difficile infection 
Organisation University of Alberta
Country Canada 
Sector Academic/University 
PI Contribution We provided metabolic profiling expertise
Collaborator Contribution Both partners provided biological samples that we analysed using our metabolic profiling expertise
Impact 3 papers have been published:- Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR. Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print] PMID: 30816855 Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. Allegretti JR, Kassam Z, Carrellas M, Mullish BH, Marchesi JR, Pechlivanis A, Smith M, Gerardin Y, Timberlake S, Pratt DS, Korzenik JR. Am J Gastroenterol. 2019 Jan 31. doi: 10.14309/ajg.0000000000000115. [Epub ahead of print] PMID: 30730351
Start Year 2015
 
Description ICiC 6 - Matthews - Medicinal Chemistry Collaborations - Prof Brennan (Oxford) 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide chemical lead hits for derivitisation
Collaborator Contribution Chemistry of bound hits to provide an expanded library. Using fragment screening experience background to contribute to the choice of fragments used in the second round of XChem fragment screening
Impact N/A
Start Year 2019
 
Description ICiC 6 - Matthews - Medicinal Chemistry Collaborations - Prof Tate's group (Imperial Chemistry Department) 
Organisation Imperial College London
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide chemical lead hits for derivitisation
Collaborator Contribution Chemistry of bound hits to provide an expanded library. Their experience in small molecule design will be utilised to develop initial hits found from XChem screens
Impact None as yet
Start Year 2019
 
Description ICiC 6 - McKay - Optimization of Modular, Exteriorly-Loaded Lipid Nanoparticles for mRNA Delivery in Human Skin Explants 
Organisation AstraZeneca
Department Pharmaceutical Technology & Development
Country United Kingdom 
Sector Private 
PI Contribution We prepare formulations and test for stability, in vitro and in vivo efficacy.
Collaborator Contribution They provide components of the materials as well as expertise in certain applications for the formulations.
Impact This collaboration has resulted in generation of data but no formal outputs to date. It is multidisciplinary; AstraZeneca: pharmaceutical development, Imperial College: formulation science, immunology, vaccinology
Start Year 2018
 
Description ICiC 6 - Overby - A collaboration between a bioengineer and a cancer doctor. 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution We (Department of Bioengineering) have developed the research programme, designed the experiments to test the hypothesis and designed the device that allows us to do this.
Collaborator Contribution They (Department of Surgery & Cancer) have provided tumour biopsy material. We are currently using material from mice, but will be beginning to include material from human patients.
Impact We are currently gathering data necessary to for publication and IP disclosure.
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation Guy's and St Thomas' NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing.
Impact Successful Stage 1 application to NIHR Programme Grants for Applied Research
Start Year 2017
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing
Impact None to date
Start Year 2018
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing
Impact None to date
Start Year 2018
 
Description ICiC 6 - Picinali - Music and Hearing Impairment 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing.
Collaborator Contribution Support in writing grant application, coordination in grant writing
Impact None to date
Start Year 2018
 
Description ICiC 6 - Rodriguez y Baena - Imperial College London and Oxford Optronix Ltd. SHINE collaboration 
Organisation Oxford Optronix Ltd
Country United Kingdom 
Sector Private 
PI Contribution The team from Imperial College London contributes in the development of the vessel detection and reconstruction method and subsequent avoidance strategy using Programmable Bevel-tip Steerable Needle system. The method will be based on the measurements of a laser Doppler flowmetry (LDF) monitor that is developed by Oxford Optronix Ltd.
Collaborator Contribution Since no commercial LDF monitor is suitable for the purpose of the SHINE project, Oxford Optronix is providing an upgraded version of their commercial, four-channel LDF system. This upgrade includes the ability to 'gate' reading from each channel, increased dynamic range in support of higher blood flow velocity, and a new type of LDF probe.
Impact Currently, there is no outcome yet.
Start Year 2018
 
Description ICiC 6 - Tate - Access to the XChem Fragment Screening Platform at the Diamond Light Source 
Organisation Diamond Light Source
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification of hit ligands, production of purified recombinant protein, and production of protein crystals labelled with hit ligand for screening on the XChem platform.
Collaborator Contribution 1. Diamond Light Source has given access to the XChem screening platform, training and supervision for users, access to beamtime on I04-1 to collect data. 2. Protein Crystallography Facility at Imperial has provided training and supervision on the XChem screening platform, performing of XChem screen, assistance and training in data collection and analysis.
Impact Identification of a new non-covalent fragment that binds to target protein (termed X01) labelled with the B01 ligand. The BAG proposal for beam time between April and October 2019 was successful and will allow a further 1-2 rounds of XChem fragment screening to grow existing covalent ligands. Collaboration is multi-disciplinary between organic chemical synthesis, biochemistry, and structural biology.
Start Year 2018
 
Description ICiC 6 - Tate - Access to the XChem Fragment Screening Platform at the Diamond Light Source 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification of hit ligands, production of purified recombinant protein, and production of protein crystals labelled with hit ligand for screening on the XChem platform.
Collaborator Contribution 1. Diamond Light Source has given access to the XChem screening platform, training and supervision for users, access to beamtime on I04-1 to collect data. 2. Protein Crystallography Facility at Imperial has provided training and supervision on the XChem screening platform, performing of XChem screen, assistance and training in data collection and analysis.
Impact Identification of a new non-covalent fragment that binds to target protein (termed X01) labelled with the B01 ligand. The BAG proposal for beam time between April and October 2019 was successful and will allow a further 1-2 rounds of XChem fragment screening to grow existing covalent ligands. Collaboration is multi-disciplinary between organic chemical synthesis, biochemistry, and structural biology.
Start Year 2018
 
Description ICiC 6 - Wigneshweraraj - Host environment dependent delivery of antibacterials by engineered phage 
Organisation Jichi Medical University
Country Japan 
Sector Academic/University 
PI Contribution Imperial: Resources
Collaborator Contribution School of Medicine, Jichi Medical University, Japan: Training and resources
Impact N/A
Start Year 2018
 
Description ICiC 6 - Matthews - School talk at Harris Academy St John's Wood 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Talk about research field at local school
Year(s) Of Engagement Activity 2019
 
Description ICiC 6 - McKay - Optimization of Modular, Exteriorly-Loaded Lipid Nanoparticles for mRNA Delivery in Human Skin Explants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 20 pupils attended an after-school science club to participate in a hands-on outreach activity and learn about preparing vaccines in the event of an outbreak.
Year(s) Of Engagement Activity 2018,2019
 
Description ICiC 6 - Picinali - Evaluating the BEARS package 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s - Evaluating the BEARS package. This was the final event of the PPI work carried out with teenager bilateral cochlear implantees.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s
 
Description ICiC 6 - Picinali - Hearing Futures II (in collaboration with the V&A Museum). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact • https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s - Hearing Futures II (in collaboration with the V&A Museum). This was an event organised to explore the need for additional research in the area of hearing assistive devices and music listening. This event fostered further networking activities, which brough to a further workshop held at Imperial College in January 2019, and consequent work for funding applications (EPSRC - Music and Hearing Impairment)
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s
 
Description ICiC6 - Stevens - Presentation at SPIE conference (Jelle Penders) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Jelle Penders presented at SPIE Photonics West conference in San Francisco, relevant to this project.
Year(s) Of Engagement Activity 2019
 
Description IiC 6 - Marchesi - Interview for TV as gut expert 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Short interview on gut health and the impact of eating junk food
Year(s) Of Engagement Activity 2018,2019