Imperial Confidence in Concept: ICIC6
Lead Research Organisation:
Imperial College London
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
- Imperial College London, United Kingdom (Collaboration, Lead Research Organisation)
- Oxford Optronix Ltd, United Kingdom (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Institute of Research in Health Sciences (Collaboration)
- University of Dundee, United Kingdom (Collaboration)
- William Harvey Hospital Kent (Collaboration)
- Imperial College Healthcare NHS Trust (Collaboration)
- Northwick Park Hospital (Collaboration)
- University of Cambridge (Collaboration)
- St Georges Hospital (Collaboration)
- AstraZeneca plc (Collaboration)
- University of Alberta (Collaboration)
- Diamond Light Source, United Kingdom (Collaboration)
- University of Nottingham (Collaboration)
- St Bartholomew's Hospital (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Nestlé (Global) (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- Brigham and Women's Hospital (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- Guy's and St Thomas' NHS Foundation Trust, London (Collaboration)
- University College Hospital Ibadan (Collaboration)
- JICHI MEDICAL UNIVERSITY (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
Publications
Allegretti J
(2019)
The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications
in The Lancet
Allegretti J
(2019)
185 Evaluating Dynamics of Bile Acid Metabolism to Predict Recurrence of Clostridioides difficile Infection
in American Journal of Gastroenterology
Allegretti J
(2019)
7 - The Icon Study: Inflammatory Bowel Disease and Recurrent Clostridium Difficile Infection: Outcomes After Fecal Microbiota Transplantation
in Gastroenterology
Allegretti J
(2019)
837 Short Chain Fatty Acid Profiles Are Altered by Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease and Recurrent Clostridioides difficile Infection
in American Journal of Gastroenterology
Allegretti JR
(2020)
Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients.
in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Allegretti JR
(2019)
Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial.
in The American journal of gastroenterology
Blakney AK
(2019)
Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA.
in Gene therapy
Chen L
(2019)
Self-supervised learning for medical image analysis using image context restoration.
in Medical image analysis
| Title | ICiC 6 - Picinali - BEARS applications prototypes video |
| Description | Video created from PPI event organised within the project. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| Impact | No notable impact up to now, except for a generally higher visibility for the project. |
| URL | https://www.youtube.com/watch?v=cvPReMtBGlk&t=100s |
| Title | ICiC 6 - Picinali - Developing the BEARs virtual reality training package (short version) |
| Description | Video created from PPI events organised within the project. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | No notable impact up to now, except for a generally higher visibility for the project. |
| URL | https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s |
| Title | ICiC 6 - Picinali - Hearing devices for music listening |
| Description | Video created from PPI events organised within the project. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | No notable impact up to now, except for a generally higher visibility for the project. |
| URL | https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s |
| Description | ICiC 6 - Clarke - Nestle PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | Nestlé (Global) |
| Sector | Private |
| Country | Switzerland |
| Start | 09/2019 |
| End | 09/2022 |
| Description | ICiC 6 - Edwards - MRC Centre for Molecular Bacteriology and Infection - Studentship |
| Amount | £96,400 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 03/2023 |
| Description | ICiC 6 - Isalan - BBSRC DTP PhD studentship |
| Amount | £80,726 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2022 |
| Description | ICiC 6 - Larrouy-Maumus - "Onestep intact cell lipids for the diagnostics and genotyping of the emerging pathogens nonTuberculous Mycobacteria |
| Amount | £35,017 (GBP) |
| Organisation | Higher Education Funding Council for England |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | ICiC 6 - Mann - Selective irreversible allosteric inhibition of MCL-1 to potentiate apoptosis in sarcomas |
| Amount | £119,873 (GBP) |
| Organisation | Sarcoma UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 08/2023 |
| Description | ICiC 6 - Matthews - MRC project grant (MR/S021191/1) |
| Amount | £650,000 (GBP) |
| Funding ID | MR/S021191/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 06/2022 |
| Description | ICiC 6 - Picinali - William Demant Foundation grant |
| Amount | £350,000 (GBP) |
| Funding ID | NDAA P79471 |
| Organisation | William Demant Holding Group |
| Sector | Private |
| Country | Denmark |
| Start | 06/2019 |
| End | 05/2022 |
| Description | ICiC 6 - Scott - Capital Award Emphasising Support for Early Career Researchers, EPSRC Internal Scheme |
| Amount | £98,373 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 03/2020 |
| Description | ICiC 6 - Tate - Dr Rita Petracca MSCA Marie-Curie fellowship |
| Amount | € 183,454 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2019 |
| End | 08/2021 |
| Description | ICiC 6 - Tate - Imperial College London Institute of Chemical Biology CDT MRes/PhD studentship. |
| Amount | £125,000 (GBP) |
| Organisation | Imperial College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | ICiC 6 - Tate - Imperial College London President's PhD Scholarship. |
| Amount | £181,000 (GBP) |
| Organisation | Imperial College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Description | ICiC 6 - Tate - Small Molecule Drug Discovery Project Award |
| Amount | £313,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2022 |
| Description | ICiC 6 - Virdyawan - _Rodriguez y Baena_Knowledge Transfer Secondment |
| Amount | £37,036 (GBP) |
| Funding ID | EP/R511547/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2020 |
| Description | ICiC 6 - Virdyawan_Rodriguez y Baena - The Global Challenges Research Fund |
| Amount | £25,500 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Department | Global Challenges Research Fund |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 07/2020 |
| Title | ICiC 6 - Bentley - Automated quantification of clinically-relevant features on brain CT |
| Description | We have developed imaging analytic software allowing for rapid, automated quantification of features on brain CT that facilitate management decisions. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Our method has been cited by an influential Government report, as an example of cost-effective medical AI technology that can improve clinical decision making and improved healthcare outcomes (Chief Medical Officer 2018). |
| Title | ICiC 6 - O'Hare - Clickable viruses |
| Description | This tool is a modified virus containing small chemical tags in its structural proteins. Such tags will provide extremely useful and versatile in many fields, but especially for the project here, in the field of novel vaccines. The aim, partly validated, is to tag these new virus particles in a completely specific manner, with desirable adducts that will inactivate infectivity while persevering immunogenicity |
| Type Of Material | Biological samples |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | None yet. |
| Title | ICiC 6 - Tate - Covalent fragment ligands for Rab27a |
| Description | A total of 56 derivatives from Series A and Series B have been synthesised, leading to an improvement in the REF for labelling Rab27a up to 140x compared to glutathione. These molecules are the starting points for on-going ligand growth/elaboration work either through secondary screening or PROTAC development. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The successful development of these tools has been a substantial factor in securing follow-on funding and studentships to continue the project beyond the duration of the current Imperial Confidence in Concept award. |
| Title | ICiC 6 - Tate - Methods for assessing reaction between covalent fragments and target molecules. |
| Description | New methods have been developed to assess the rate of covalent modification of a protein using a fluorescence anisotropy readout (rather than fluorescence intensity in the original QIT assay). This new method allows from more sensitive detection of labelling in more dilute protein samples. Secondary confirmation assays (intact protein mass spectrometry, peptide mass fingerprinting, differential scanning fluorimetry) have also been integrated into the QIT screen. These methods have allowed assessment of newly synthesised ligands at lower concentrations which are closer to those required for cellular assays. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | These methods have allowed assessment of newly synthesised ligands at lower concentrations which are closer to those required for cellular assays and allowed for a more streamline and robust analysis of ligands. The development of these methods has been key in demonstrating the quality of our ligands and supporting future development of improved ligands, an important factor in securing follow-on funding |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | Imperial College Healthcare NHS Trust |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | Northwick Park Hospital |
| Department | Stroke services |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | St Bartholomew's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | St Georges Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | University College Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Bentley - NIHR CRN stroke |
| Organisation | William Harvey Hospital Kent |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Partner organisations are provided with administrative costs and credit for research accruals by NIHR |
| Collaborator Contribution | Identification, extraction, collation of imaging and clinical data |
| Impact | Publication: Chen et al 2018, Radiology. Rapid automated quantification of leukoaraiosis on brain CT. Our project involves collaboration with 15 UK and 1 Indian academic partners from whom we are recruiting and collecting prospective and retrospective data from via NIHR CRN. This allows us to build one of the largest global stroke imaging databases. |
| Start Year | 2014 |
| Description | ICiC 6 - Blagborough - Field-Assessment of Novel Native GPI-Anchored-Protein Based Anti-Malarial Vaccines |
| Organisation | Institute of Research in Health Sciences |
| Country | Burkina Faso |
| Sector | Public |
| PI Contribution | Coordination of experimental planning, support in writing grant applications and coordination of experimental activities. |
| Collaborator Contribution | Support in writing grant applications and coordination of experimental activities. |
| Impact | 1. Multiple grant applications to MRC, currently awaiting outcome 2. Award of Alborada Trust Grant to both collaborators to continue research. 3. Successful Stage 1 application to NIHR |
| Start Year | 2018 |
| Description | ICiC 6 - Clarke - Probiotic approaches to combat antibiotic associated diarrhea and enteric infection |
| Organisation | Nestlé (Global) |
| Department | Nestlé UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We will supervise a PhD student. |
| Collaborator Contribution | Provided funding for PhD student |
| Impact | None as yet. |
| Start Year | 2018 |
| Description | ICiC 6 - Edwards - ICiC partnership |
| Organisation | University of Dundee |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We developed tools for drug screening to discover new antibacterial molecules. |
| Collaborator Contribution | They provided expertise, facilities and a compound library for the screening. |
| Impact | None yet |
| Start Year | 2019 |
| Description | ICiC 6 - Larrouy-Maumus - Colistin resistant at Imperial NHS Trust |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide access to MALDxin and expertise in lipidomics (Department of Life Sciences) |
| Collaborator Contribution | Provide clinical isolates and expertise in infectious diseases (NHLI and Department of Infectios Disease [formally Department of Medicine]) |
| Impact | No outputs so far. Clinical and basic science collaborators. |
| Start Year | 2019 |
| Description | ICiC 6 - Larrouy-Maumus - Colistin resistant at Imperial NHS Trust |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide access to MALDxin and expertise in lipidomics (Department of Life Sciences) |
| Collaborator Contribution | Provide clinical isolates and expertise in infectious diseases (NHLI and Department of Infectios Disease [formally Department of Medicine]) |
| Impact | No outputs so far. Clinical and basic science collaborators. |
| Start Year | 2019 |
| Description | ICiC 6 - Larrouy-Maumus - Colistin resistant at Imperial NHS Trust |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide access to MALDxin and expertise in lipidomics (Department of Life Sciences) |
| Collaborator Contribution | Provide clinical isolates and expertise in infectious diseases (NHLI and Department of Infectios Disease [formally Department of Medicine]) |
| Impact | No outputs so far. Clinical and basic science collaborators. |
| Start Year | 2019 |
| Description | ICiC 6 - Marchesi - Bile salt hydrolase and valerate: novel treatments to prevent and treat Clostridium difficile infection |
| Organisation | Brigham and Women's Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | We provided metabolic profiling expertise |
| Collaborator Contribution | Both partners provided biological samples that we analysed using our metabolic profiling expertise |
| Impact | 3 papers have been published:- Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR. Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print] PMID: 30816855 Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. Allegretti JR, Kassam Z, Carrellas M, Mullish BH, Marchesi JR, Pechlivanis A, Smith M, Gerardin Y, Timberlake S, Pratt DS, Korzenik JR. Am J Gastroenterol. 2019 Jan 31. doi: 10.14309/ajg.0000000000000115. [Epub ahead of print] PMID: 30730351 Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota. McDonald JAK, Mullish BH, Pechlivanis A, Liu Z, Brignardello J, Kao D, Holmes E, Li JV, Clarke TB, Thursz MR, Marchesi JR. Gastroenterology. 2018 Nov;155(5):1495-1507.e15. doi: 10.1053/j.gastro.2018.07.014. Epub 2018 Jul 17. PMID: 30025704 |
| Start Year | 2015 |
| Description | ICiC 6 - Marchesi - Bile salt hydrolase and valerate: novel treatments to prevent and treat Clostridium difficile infection |
| Organisation | University of Alberta |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We provided metabolic profiling expertise |
| Collaborator Contribution | Both partners provided biological samples that we analysed using our metabolic profiling expertise |
| Impact | 3 papers have been published:- Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR. Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print] PMID: 30816855 Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial. Allegretti JR, Kassam Z, Carrellas M, Mullish BH, Marchesi JR, Pechlivanis A, Smith M, Gerardin Y, Timberlake S, Pratt DS, Korzenik JR. Am J Gastroenterol. 2019 Jan 31. doi: 10.14309/ajg.0000000000000115. [Epub ahead of print] PMID: 30730351 Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota. McDonald JAK, Mullish BH, Pechlivanis A, Liu Z, Brignardello J, Kao D, Holmes E, Li JV, Clarke TB, Thursz MR, Marchesi JR. Gastroenterology. 2018 Nov;155(5):1495-1507.e15. doi: 10.1053/j.gastro.2018.07.014. Epub 2018 Jul 17. PMID: 30025704 |
| Start Year | 2015 |
| Description | ICiC 6 - Matthews - Medicinal Chemistry Collaborations - Prof Brennan (Oxford) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide chemical lead hits for derivitisation |
| Collaborator Contribution | Chemistry of bound hits to provide an expanded library. Using fragment screening experience background to contribute to the choice of fragments used in the second round of XChem fragment screening |
| Impact | N/A |
| Start Year | 2019 |
| Description | ICiC 6 - Matthews - Medicinal Chemistry Collaborations - Prof Tate's group (Imperial Chemistry Department) |
| Organisation | Imperial College London |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide chemical lead hits for derivitisation |
| Collaborator Contribution | Chemistry of bound hits to provide an expanded library. Their experience in small molecule design will be utilised to develop initial hits found from XChem screens |
| Impact | None as yet |
| Start Year | 2019 |
| Description | ICiC 6 - McKay - Optimization of Modular, Exteriorly-Loaded Lipid Nanoparticles for mRNA Delivery in Human Skin Explants |
| Organisation | AstraZeneca |
| Department | Pharmaceutical Technology & Development |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We prepare formulations and test for stability, in vitro and in vivo efficacy. |
| Collaborator Contribution | They provide components of the materials as well as expertise in certain applications for the formulations. |
| Impact | This collaboration has resulted in generation of data but no formal outputs to date. It is multidisciplinary; AstraZeneca: pharmaceutical development, Imperial College: formulation science, immunology, vaccinology |
| Start Year | 2018 |
| Description | ICiC 6 - Overby - A collaboration between a bioengineer and a cancer doctor. |
| Organisation | Imperial College London |
| Department | Department of Bioengineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The engineer aims to design a device to take a biopsy specimen from a tumour (provided by the cancer doctor) and put the biopsy specimen within a microfluidics device. The goal is to maintain the viability of the specimen ex vivo for cancer screening applications. Viability is accomplished via perfusion of nutrient-containing medium through the specimen. We (Department of Bioengineering) have developed the research programme, designed the experiments to test the hypothesis and designed the device that allows us to do this. |
| Collaborator Contribution | They (Department of Surgery & Cancer) have provided tumour biopsy material. We are currently using material from mice, but will be beginning to include material from human patients. |
| Impact | We are currently gathering data necessary to for publication and IP disclosure. Collaboration is multi-disciplinary. Bioengineer and a clinician specilaising in cancer. |
| Start Year | 2018 |
| Description | ICiC 6 - Overby - A collaboration between a bioengineer and a cancer doctor. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The engineer aims to design a device to take a biopsy specimen from a tumour (provided by the cancer doctor) and put the biopsy specimen within a microfluidics device. The goal is to maintain the viability of the specimen ex vivo for cancer screening applications. Viability is accomplished via perfusion of nutrient-containing medium through the specimen. We (Department of Bioengineering) have developed the research programme, designed the experiments to test the hypothesis and designed the device that allows us to do this. |
| Collaborator Contribution | They (Department of Surgery & Cancer) have provided tumour biopsy material. We are currently using material from mice, but will be beginning to include material from human patients. |
| Impact | We are currently gathering data necessary to for publication and IP disclosure. Collaboration is multi-disciplinary. Bioengineer and a clinician specilaising in cancer. |
| Start Year | 2018 |
| Description | ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. |
| Organisation | Guy's and St Thomas' NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing. |
| Impact | Successful Stage 1 application to NIHR Programme Grants for Applied Research |
| Start Year | 2017 |
| Description | ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing. |
| Impact | Successful Stage 1 application to NIHR Programme Grants for Applied Research |
| Start Year | 2017 |
| Description | ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing. |
| Impact | Successful Stage 1 application to NIHR Programme Grants for Applied Research |
| Start Year | 2017 |
| Description | ICiC 6 - Picinali - Both EARS training package (BEARS) to maximise hearing abilities in teenage bilateral cochlear implant users. |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing. |
| Impact | Successful Stage 1 application to NIHR Programme Grants for Applied Research |
| Start Year | 2017 |
| Description | ICiC 6 - Picinali - Music and Hearing Impairment |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grand writing. |
| Collaborator Contribution | support in writing grant application, coordination in grand writing. |
| Impact | Successful proposal, research funded by the William Demant Foundation, project started in June 2019 |
| Start Year | 2018 |
| Description | ICiC 6 - Picinali - Music and Hearing Impairment |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing |
| Impact | Submission of an EPSRC responsive mode proposal (submitted 30th of January 2020) |
| Start Year | 2018 |
| Description | ICiC 6 - Picinali - Music and Hearing Impairment |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing |
| Impact | Submission of an EPSRC responsive mode proposal (submitted 30th of January 2020) |
| Start Year | 2018 |
| Description | ICiC 6 - Picinali - Music and Hearing Impairment |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Support in writing grant application, coordination of early PPI stage, early development of prototypes and coordination in grant writing. |
| Collaborator Contribution | Support in writing grant application, coordination in grant writing |
| Impact | Submission of an EPSRC responsive mode proposal (submitted 30th of January 2020) |
| Start Year | 2018 |
| Description | ICiC 6 - Rodriguez y Baena - Imperial College London and Oxford Optronix Ltd. SHINE collaboration |
| Organisation | Oxford Optronix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The team from Imperial College London contributes in the development of the vessel detection and reconstruction method and subsequent avoidance strategy using Programmable Bevel-tip Steerable Needle system. The method will be based on the measurements of a laser Doppler flowmetry (LDF) monitor that is developed by Oxford Optronix Ltd. |
| Collaborator Contribution | Since no commercial LDF monitor is suitable for the purpose of the SHINE project, Oxford Optronix is providing an upgraded version of their commercial, four-channel LDF system. This upgrade includes the ability to 'gate' reading from each channel, increased dynamic range in support of higher blood flow velocity, and a new type of LDF probe. |
| Impact | Currently, there is no outcome yet. |
| Start Year | 2018 |
| Description | ICiC 6 - Tate - Access to the XChem Fragment Screening Platform at the Diamond Light Source |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Identification of hit ligands, production of purified recombinant protein, and production of protein crystals labelled with hit ligand for screening on the XChem platform. |
| Collaborator Contribution | 1. Diamond Light Source has given access to the XChem screening platform, training and supervision for users, access to beamtime on I04-1 to collect data. 2. Protein Crystallography Facility at Imperial has provided training and supervision on the XChem screening platform, performing of XChem screen, assistance and training in data collection and analysis. |
| Impact | Identification of a new non-covalent fragment that binds to target protein (termed X01) labelled with the B01 ligand. The BAG proposal for beam time between April and October 2019 was successful and will allow a further 1-2 rounds of XChem fragment screening to grow existing covalent ligands. Collaboration is multi-disciplinary between organic chemical synthesis, biochemistry, and structural biology. |
| Start Year | 2018 |
| Description | ICiC 6 - Tate - Access to the XChem Fragment Screening Platform at the Diamond Light Source |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identification of hit ligands, production of purified recombinant protein, and production of protein crystals labelled with hit ligand for screening on the XChem platform. |
| Collaborator Contribution | 1. Diamond Light Source has given access to the XChem screening platform, training and supervision for users, access to beamtime on I04-1 to collect data. 2. Protein Crystallography Facility at Imperial has provided training and supervision on the XChem screening platform, performing of XChem screen, assistance and training in data collection and analysis. |
| Impact | Identification of a new non-covalent fragment that binds to target protein (termed X01) labelled with the B01 ligand. The BAG proposal for beam time between April and October 2019 was successful and will allow a further 1-2 rounds of XChem fragment screening to grow existing covalent ligands. Collaboration is multi-disciplinary between organic chemical synthesis, biochemistry, and structural biology. |
| Start Year | 2018 |
| Description | ICiC 6 - Wigneshweraraj - Host environment dependent delivery of antibacterials by engineered phage |
| Organisation | Jichi Medical University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Imperial: Resources |
| Collaborator Contribution | School of Medicine, Jichi Medical University, Japan: Training and resources |
| Impact | N/A |
| Start Year | 2018 |
| Title | USE OF AXL, CCL19 AND/OR BMP-6 FOR PROMOTING WOUND HEALING |
| Description | The invention relates to the treatment of a wound, and in particular to uses of polypeptides (or genetic constructs or vectors encoding such peptides) to promote wound healing and/or reduce, prevent or inhibit scarring. The invention extends to pharmaceutical compositions comprising such polypeptides or constructs, for treating wounds, and for reducing scarring, and cosmetic formulations for improving the appearance of skin. The invention also extends to wound dressings, formulations and bandages comprising such polypeptides. |
| IP Reference | WO2019180419 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | No |
| Impact | Helena Topouzi, co-inventor on the patent has secured 3 months funding to be a techcelerate fellow at Imperial College. We have started a collaboration with Dr Kyle Quinn, to evaluate the efficacy of sAXL in murine wounds in vivo. |
| Title | ICiC 6 - Rodriguez - LDF for Deep Brain Vessel Detection |
| Description | In the next seven months, we will perform animal trials to optimise the performance of the vessel detection system developed in this Confidence in Concept. Together with the programmable bevel-tip needle that has been developed in the EDEN2020 project. |
| Type | Support Tool - For Medical Intervention |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2020 |
| Development Status | Under active development/distribution |
| Impact | The device is still under development. |
| Title | ICiC 6 - Rodriguez Y Baena - Vessel Detection method using a steerable needle system |
| Description | A laser Doppler flowmetry sensor is embedded within each segment of a programmable bevel-tip needle to detect a blood vessel. A type of machine learning network was used to interpret sensor data. Using this method, information with regards to vessel size and pose can be extracted. |
| Type Of Technology | Detection Devices |
| Year Produced | 2018 |
| Impact | A programmable bevel-tip needle embedded with optical sensors to detect and predict vessel pose in front of it can be used to perform haemorrhage free intervention. This method is useful for minimally invasive brain surgery since haemorrhage during this procedure can be life-threatening. |
| Description | ICiC 6 - Blagborough - Cambridge Science Festival and Imperial Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 300 people attended multiple events designed to showcase our research - engagement sparked multiple questions and discussion, with multiple requests for people to attend and get involved with the research in the future. |
| Year(s) Of Engagement Activity | 2017,2018,2019,2020 |
| Description | ICiC 6 - Edwards - Great exhibition Rd festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | >2000 people visited the infection zone at the festival. We used a variety of games and props to explain the work, including a 'DNA repair Jenga' game. This led to questions and discussions about our work from members of the public. |
| Year(s) Of Engagement Activity | 2019 |
| Description | ICiC 6 - Larrouy-Maumus - Imperial College Alumni |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Generate enthusiasm in infectious diseases and awareness on the growing concern of AMR |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.imperial.ac.uk/news/194088/thank-from-professor-tom-welton-dean/ |
| Description | ICiC 6 - Larrouy-Maumus - Imperial College Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Generate enthusiasm in infectious diseases and awareness on the growing concern of antimicrobial resistance |
| Year(s) Of Engagement Activity | 2019 |
| Description | ICiC 6 - Marchesi - BBC Radio 5 discussion |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussion of the gut microbiome |
| Year(s) Of Engagement Activity | 2019 |
| Description | ICiC 6 - Marchesi - Tortoise ThinkIn - Go with your gut - Discussion |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | General discussion of the gut and gut microbiota, with a Q and A |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=31wE_TD_vqI&feature=youtu.be |
| Description | ICiC 6 - Matthews - School talk at Harris Academy St John's Wood |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Talk about research field at local school |
| Year(s) Of Engagement Activity | 2019 |
| Description | ICiC 6 - McKay - Optimization of Modular, Exteriorly-Loaded Lipid Nanoparticles for mRNA Delivery in Human Skin Explants |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 20 pupils attended an after-school science club to participate in a hands-on outreach activity and learn about preparing vaccines in the event of an outbreak. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | ICiC 6 - Picinali - Evaluating the BEARS package |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Evaluating the BEARS package. This was the final event of the PPI work carried out with teenager bilateral cochlear implantees. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=E-Rn7ipiJAg&t=10s |
| Description | ICiC 6 - Picinali - Hearing Futures II (in collaboration with the V&A Museum). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | • Hearing Futures II (in collaboration with the V&A Museum). This was an event organised to explore the need for additional research in the area of hearing assistive devices and music listening. This event fostered further networking activities, which brough to a further workshop held at Imperial College in January 2019, and consequent work for funding applications (EPSRC - Music and Hearing Impairment) |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=Dze5oBgwTxc&t=16s |
| Description | ICiC 6 - Rodriguez - The Great Exhibition Road Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | During the Great Exhibition Road Festival, we presented a simulation of a steerable needle with a vessel avoidance system. In the simulation, audiences controlled the movement of the needle with a joystick, which emulates a pc game. This format of presentation attracted many children to try. After they played the 'game', we then explained how the system works. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.imperial.ac.uk/news/191848/eden2020-the-great-exhibition-road-festival/ |
| Description | ICiC6 - Stevens - Presentation at SPIE conference (Jelle Penders) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Jelle Penders presented at SPIE Photonics West (The International Society for Optics and Photonics) conference in San Francisco, relevant to this project. |
| Year(s) Of Engagement Activity | 2019 |
| Description | IiC 6 - Marchesi - Interview for TV as gut expert |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Short interview on gut health and the impact of eating junk food |
| Year(s) Of Engagement Activity | 2018,2019 |