UCL Application for a Mental Health Data Pathfinder award

Lead Research Organisation: University College London

Abstract

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Technical Summary

UCL’s cross-disciplinary mental health research is world leading, with current mental health grant activity in excess of £100M. Our Mental Health Data Pathfinder proposal brings together research leaders from across our mental health and neuroscience Divisions and Institutes, and integrates our unparalleled infrastructure and expertise in Population Health Sciences and Health Informatics. The application builds on our track record in neurosciences, epidemiology and mental health database research. Our four projects are ambitious and deliverable, representing a range of research disciplines that will meet several pathfinder data challenges, and will deliver real impact on data quality and methods in mental health research.
Project 1 will exploit national psychology service (IAPT) data, enrich it with new cognitive data, and use novel methods to predict treatment responses and mechanisms underlying prognosis.
Project 2 will integrate UCL BRC BioResource data into Mental Health Electronic Health Records in North London to generate novel longitudinal datasets suitable for genetic, neuroimaging and biological research. The proof-of-concept pilot project includes pharmacogenetics and neuroimaging.
Project 3 will capitalise on UCL’s extensive cohort resource. We will apply new methods to harmonise variables in cohorts facilitating novel longitudinal mental health research across the life-course.
Project 4 enhances UCL’s Electronic Mental Health Record capacity through new linkage, new data discovery methods, involving large databases of adults and/or children in primary and secondary care. This will determine the effectiveness, precision and safety of mental health interventions.
UCL is actively prioritising mental health research capacity, including its new Institute for Mental Health. This Pathfinder application has cross-Faculty support and includes an Institutional commitment of £1.2M to support research, which will contribute to the National Mental Health Data Platform.

Publications

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