Imperial Confidence in Concept
Lead Research Organisation:
Imperial College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Imperial Confidence in Concept: ICIC7
Organisations
- Imperial College London (Lead Research Organisation)
- CAIRN Research Ltd (Collaboration)
- Tropical Gastroenterology & Nutrition group (TROPGAN) (Collaboration)
- Photonamic (Collaboration)
- National Health Service (Collaboration)
- Brucker (Collaboration)
- Indian Institute of Technology Guwahati (Collaboration)
- University of Cape Town (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
Publications
Leiloglou M
(2020)
Snapshot Hyperspectral System for Breast Conserving Surgery Guidance
Walsh K
(2021)
Development of a legume-enriched feed for treatment of severe acute malnutrition.
in Wellcome open research
Garcia E
(2021)
Application of direct stochastic optical reconstruction microscopy (dSTORM) to the histological analysis of human glomerular disease.
in The journal of pathology. Clinical research
Higham SL
(2023)
Intranasal immunization with outer membrane vesicles (OMV) protects against airway colonization and systemic infection with Acinetobacter baumannii.
in The Journal of infection
Kedrzycki MS
(2023)
Guidance in breast-conserving surgery: tumour localization versus identification.
in The British journal of surgery
Farhan F
(2023)
Extracellular matrix modulates the spatial hepatic features in hepatocyte-like cells derived from human embryonic stem cells.
in Stem cell research & therapy
Leiloglou M
(2022)
Indocyanine green fluorescence image processing techniques for breast cancer macroscopic demarcation.
in Scientific reports
Mielcarek M
(2021)
Polyglutamine diseases: looking beyond the neurodegenerative universe.
in Neural regeneration research
McHugh D
(2023)
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
in Nature cell biology
Blight J
(2021)
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.
in Life science alliance
Leiloglou M
(2021)
Tissue texture extraction in indocyanine green fluorescence imaging for breast-conserving surgery
in Journal of Physics D: Applied Physics
Lightley J
(2023)
openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation.
in Journal of microscopy
Lightley J
(2022)
Robust deep learning optical autofocus system applied to automated multiwell plate single molecule localization microscopy.
in Journal of microscopy
Yan J
(2022)
Super-Resolution Ultrasound Through Sparsity-Based Deconvolution and Multi-Feature Tracking.
in IEEE transactions on medical imaging
Koutsoftidis S
(2022)
Myolink: A 128-Channel, [Formula: see text], Embedded Recording System, Optimized for High-Density Surface Electromyogram Acquisition.
in IEEE transactions on bio-medical engineering
Zielonka D
(2020)
Prevalence of Non-psychiatric Comorbidities in Pre-symptomatic and Symptomatic Huntington's Disease Gene Carriers in Poland.
in Frontiers in medicine
Kedrzycki M
(2021)
P053. Prospective single-centre qualitative service evaluation on magseed for wide local excision
in European Journal of Surgical Oncology
Teh J
(2021)
392 Magseed-Guided Wide Local Excision During the COVID-19 Pandemic: A Tenable Solution to Barriers in Accessing Elective Breast Cancer Surgery
in British Journal of Surgery
Leiloglou M
(2021)
ASO Author Reflections: Towards Fluorescence Guided Tumor Identification for Precision Breast Conserving Surgery
in Annals of Surgical Oncology
Kedrzycki MS
(2021)
Meta-analysis Comparing Fluorescence Imaging with Radioisotope and Blue Dye-Guided Sentinel Node Identification for Breast Cancer Surgery.
in Annals of surgical oncology
Kedrzycki MS
(2021)
ASO Author Reflections: Fluorescence-Guided Sentinel Node Biopsy for Breast Cancer.
in Annals of surgical oncology
| Title | ICiC 7 - Maitland - MIMBLE film local made nutrition feeds for malnutrition |
| Description | Film about nutrition feeds |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2023 |
| Impact | none- film still in draft mode |
| URL | https://vimeo.com/784346152/4223ef8c98 |
| Description | DT-Prime award - Isalan - ICiC 7 |
| Amount | £101,856 (GBP) |
| Organisation | Imperial College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2022 |
| End | 07/2022 |
| Description | ICiC - Masouros - EPSRC Impact Accelerator Award |
| Amount | £70,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2021 |
| Description | ICiC 7 - Farina - H2020 EUROBENCH FSTP-2 |
| Amount | € 59,992 (EUR) |
| Funding ID | P90050 |
| Organisation | Spanish National Research Council (CSIC) |
| Sector | Public |
| Country | Spain |
| Start | 08/2021 |
| End | 05/2022 |
| Description | ICiC 7 - French - CRUK Convergence Science Centre Clinical Academic Training Programme Intercalated PhD Award in 2020 |
| Amount | £117,019 (GBP) |
| Funding ID | C309/A31316 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 06/2023 |
| Description | ICiC 7 - French - Knowledge Transfer Secondment (KTS) from EPSRC Impact Acceleration Account at Imperial |
| Amount | £15,126 (GBP) |
| Funding ID | EP/R511547/1 |
| Organisation | Imperial College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 12/2019 |
| Description | ICiC 7 - French - Silicon Valley Community Foundation - CZI Advancing Imaging Through Collaborative Projects Progress Report |
| Amount | $349,871 (USD) |
| Organisation | Silicon Valley Community Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2023 |
| End | 02/2025 |
| Description | ICiC 7 - Leff - The Hamlyn Accelerator for Surgical Innovation |
| Amount | £49,888 (GBP) |
| Funding ID | PSZo87 NQHAM |
| Organisation | Imperial College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 04/2022 |
| Description | ICiC 7 - Maitland - Research England - International Science Partnerships Fund (ISPF) 2023/24 Global Development Hub ODA Project Accelerator |
| Amount | £60,200 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2024 |
| End | 07/2024 |
| Description | ICiC 7 - Maitland - UKRI GCRF and Newton Consolidation Accounts GNCA |
| Amount | £50,411 (GBP) |
| Funding ID | PSO023_WRDN |
| Organisation | Imperial College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 03/2023 |
| Description | ICiC 7 - Masouros - Impact Accelerator Award UKRI (EPSRC) |
| Amount | £80,606 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2024 |
| Title | Effect of ECM on zonal hepatocyte maturation and function - ICiC 7 - Baum |
| Description | We found that collagen and matrigel affect hESC-derived hepatocytes to have distinct functions reflecting hepatocytes of different spatial location in the liver lobule. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | our findings, together with tissue engineering technology, could facilitate the generation of liver tissues that resemble the liver lobular structure by applying different ECMs along the periportal-pericentral axis. |
| Title | ICIC 7 - French - Super-resolved immunofluorescence applied to histopathology of kidney disease |
| Description | We demonstrated the potential to use super-resolved immunofluorescence for the diagnosis of kidney disease, viewing ultrastructure not accessible with conventional immunofluorescence |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Super-resolved immunofluorescence may provide a low-cost alternative to electron microscopy for histopathology - potentially enhancing the diagnosis of kidney disease where EM is not available. |
| Title | ICiC 7 - Farina - MyoLink High Density sEMG recording system |
| Description | Multi-channel sEMG recording device with noise floor of <0.4uVrms - lower than currently available commercial systems. (Feb 2023) |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Increased number of observed neural activity |
| URL | https://pubmed.ncbi.nlm.nih.gov/35468056/ |
| Title | ICiC 7 - French - OpenFrame |
| Description | We have continued to develop open-source microscopes |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | paper, online resources |
| URL | https://www.imperial.ac.uk/photonics/research/biophotonics/instruments--software/fluorescence-micros... |
| Title | ICiC 7 - Tate - Assay development |
| Description | We developed a time course cell-based assay to assess the ability of compounds to inhibit CD59 function |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | We developed a time course cell-based assay to assess the ability of compounds to inhibit CD59 function |
| Description | ICiC 7 - French - Carin Research Ltd |
| Organisation | CAIRN Research Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We worked with Cairn Research Instruments in developing our open source microscopy tools, including the openFrame platform. Cairn also manufacture and sell components that can be used to assemble the low-cost histoSTORM microscope that we developed. This enables other laboratories to replicate our work. |
| Collaborator Contribution | Cairn worked with us to finalise the design of the openFrame microscope, which they now sell. The design is open source and CAD files are freely available. |
| Impact | Cairn are able to manufacture and sell components to customers wishing to assemble their own microscope systems |
| Start Year | 2019 |
| Description | ICiC 7 - French - IITG |
| Organisation | Indian Institute of Technology Guwahati |
| Country | India |
| Sector | Academic/University |
| PI Contribution | We sent an openFrame microscope system to IITG supported by a parallel Imperial GCRF grant and we will transfer expertise developed during this ICiC project to IITG to apply this to (super-resolved immunofluorescence) histopathology |
| Collaborator Contribution | N/A |
| Impact | IITG will be able to undertake research into the development and application of cost-effective microscope systems for histopathology, including super-resolved immunofluorescence, which could be useful, e.g. to help diagnose kidney disease where clinical electron microscopy is not available. |
| Start Year | 2019 |
| Description | ICiC 7 - French - openScopes Africa |
| Organisation | University of Cape Town |
| Department | Institute of Infectious Disease and Molecular Medicine (IIDMM) |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Developing open-source cost-effective research-grade microscopes for Africa, including for pathology and study of TB |
| Collaborator Contribution | They are the end users and experts in TB |
| Impact | N/A |
| Start Year | 2023 |
| Description | ICiC 7 - Larrouy-Maumus - Consolidate collaboration agreement with Bruker microbiology |
| Organisation | Brucker |
| Country | United States |
| Sector | Private |
| PI Contribution | MALDI measurements |
| Collaborator Contribution | MALDI knowledge and access to MALDI equipment hosted in my laboratory |
| Impact | N/A |
| Start Year | 2023 |
| Description | ICiC 7 - Leff - "AHA" |
| Organisation | Photonamic |
| Country | Germany |
| Sector | Private |
| PI Contribution | We have offered to trial the ALA in a 40-patient feasibility study. |
| Collaborator Contribution | Photonamic GmbH have contributed 60 vials of ALA. |
| Impact | N/A |
| Start Year | 2021 |
| Description | ICiC 7 - Maitland - MIMBLE 3 trial grant |
| Organisation | Tropical Gastroenterology & Nutrition group (TROPGAN) |
| Country | Zambia |
| Sector | Charity/Non Profit |
| PI Contribution | Development of a trial grant |
| Collaborator Contribution | Expertise in gut health and biomakers |
| Impact | None |
| Start Year | 2022 |
| Description | ICiC 7 - Masouros - UoS |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | N/A |
| Collaborator Contribution | They provided advice for us, and carried out tests with our device. We applied together (with me as the PI) to NIHR for further funding. |
| Impact | N/A |
| Start Year | 2019 |
| Description | ICiC 7 - Masouros - tissue viability nurse |
| Organisation | National Health Service |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | none |
| Collaborator Contribution | Research nurse time |
| Impact | none |
| Start Year | 2022 |
| Title | ACTIVE DELIVERY OF NUCLEIC ACIDS AND PEPTIDES, METHODS AND USES |
| Description | Disclosed herein are polypeptides for use in treating diseases. Therapeutic uses and methods for treating diseases are also disclosed. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro. |
| IP Reference | WO2022003363 |
| Protection | Patent application published |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | We are looking to using it to set up a start-up |
| Title | CELL THERAPY |
| Description | The present invention relates to methods for the production of immune cells and immunomodulatory cells expressing a transgene of interest, using lentiviral vectors. The invention also relates to populations of cells produced by such methods and uses thereof. |
| IP Reference | WO2022219336 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | N/A |
| Title | DEVICE FOR SUPPORTING A BODY PART |
| Description | A method of supporting a body part (16), comprising providing a device (100) comprising: a first portion (105) configured to support a body part, wherein, in use, the body part applies a first pressure to the first portion in a first direction; means for detecting the first pressure; and a second portion (115) having means (212) for applying a second pressure to the body part in a second direction substantially perpendicular to the first direction; detecting the first pressure; determining the second pressure based on a user parameter; and applying the second pressure to the body part in the second direction at a pre-determined ratio relative to the first pressure using said means for applying the second pressure. |
| IP Reference | WO2020053586 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | N/A |
| Title | NMT INHIBITORS FOR TREATING SENESCENCE-ASSOCIATED DISEASES OR DISORDERS |
| Description | The present invention provides a NMT inhibitor for use in the prophylaxis or treatment of a senescence-associated disease or disorder. |
| IP Reference | WO2022090746 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | Yes |
| Impact | N/A |
| Title | POLY(L-LYSINE ISOPHTHALAMIDE) (PLP) POLYMERS WITH HYDROPHOBIC PENDANT CHAINS |
| Description | The present disclosure relates to the provision of novel biodegradable amphiphilic peptides and peptide analogues based on poly(L-lysine isophthalamide)(PLP) derivatives comprising hydrophobic chains and their use in the permeabilization of mammalian cells and delivery of agents, for example therapeutic agents, imaging agents and cell preservation agents. |
| IP Reference | WO2018011580 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | N/A |
| Title | THERAPEUTIC NUCLEIC ACIDS, PEPTIDES AND USES I |
| Description | Disclosed herein are polypeptides for use in treating diseases associated with pathogenic genomic repeat sequences, such as neurological disorders. Also disclosed are nucleic acid molecules and vectors that encode such polypeptides. Therapeutic uses and methods for treating such diseases are also disclosed; in particular, therapeutic uses and methods comprising complementary pairs and combinations of therapeutic polypeptides, nucleic acids or vectors. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro. |
| IP Reference | WO2022003361 |
| Protection | Patent application published |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | We are looking to using it to set up a start-up |
| Title | THERAPEUTIC NUCLEIC ACIDS, PEPTIDES AND USES II |
| Description | Disclosed herein are polypeptides for use in treating diseases associated with pathogenic genomic repeat sequences, such as neurological disorders. Also disclosed are nucleic acid molecules and vectors that encode such polypeptides. Therapeutic uses and methods for treating such diseases are also disclosed; in particular, therapeutic uses and methods comprising complementary pairs and combinations of therapeutic polypeptides, nucleic acids or vectors. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro. |
| IP Reference | WO2022003362 |
| Protection | Patent application published |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | We are looking to using it to set up a start-up |
| Title | ICiC 7 - French - Open source microscope applied to histopathology using super-resolved immunofluorescence: histoSTORM |
| Description | We developed an open source super-resolving immunofluorescence microscope and protocols to process frozen or FFPE histological sections. We performed STORM microscopy to obtain super-resolved immunofluorescence images of clinical histology sections from kidney tissue biopsies, which were compared to diagnostic EM images of tissue from the same biopsy. We demonstrated that histoSTORM provided added value to the standard brightfield and immunofluorescence images, indicting to replace EM in some situations - and to be useful where clinical diagnostic EM is not available |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2021 |
| Development Status | Actively seeking support |
| Impact | We will apply for an NIHR i4i grant to develop the instrument for a clinical trial |
| Title | ICiC 7 - Stevens - SPARTA® platform development |
| Description | SPARTAÒ is a novel nanoparticle characterisation technology that enables the analysis of viral vectors for gene therapy applications. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2022 |
| Development Status | Under active development/distribution |
| Impact | N/A |
| Title | ICiC 7 - French - openFrame |
| Description | open-source microscope |
| Type Of Technology | New/Improved Technique/Technology |
| Year Produced | 2022 |
| Open Source License? | Yes |
| Impact | in use in India and South Africa |
| URL | https://www.imperial.ac.uk/photonics/research/biophotonics/instruments--software/fluorescence-micros... |
| Company Name | SPARTA Biodiscovery |
| Description | SPARTA Biodiscovery develops the technology to research nanoparticles enabling nanoformulations for therapeutics. |
| Year Established | 2022 |
| Impact | n/a |
| Website | https://spartabiodiscovery.com/ |
| Description | ICiC 7 - French - Half term outreach activity for families |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | My group, including ICiC employed PDRA and my PhD students, have developed an activity to introduce the public - and specifically school children to microscopy and its application to medicine. We held a successful engagement event with primary school children and their families at White City on 02/06/2021, where this event had the highest attendance (30 children and parents) across a programme of half term activities. |
| Year(s) Of Engagement Activity | 2021 |
| Description | ICiC 7 - French - Imperial Lates |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | We had a stand as part of Imperial Lates and members of public stopped by |
| Year(s) Of Engagement Activity | 2023 |
| Description | ICiC 7 - Larrouy-Maumus - Invited speaker at national conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | invited speaker at 22nd conference in Genomics and Proteomics at Middlesex University |
| Year(s) Of Engagement Activity | 2023 |
| Description | ICiC 7 - Maitland - Severe malnutrition Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Closed meeting to discuss management of severe malnutrition with international experts |
| Year(s) Of Engagement Activity | 2023 |
| Description | ICiC 7 - Maitland - We met with WHO, World Food Programme and UNICEF about our philosophy for redesigning nutritional feeds which could be manufactured locally in African countries rather than being obtained from Europe/elsewhere |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | We held a teleconference with the policy makers and had a closed meeting in January 2023 which a number of stakeholders attended including WHO |
| Year(s) Of Engagement Activity | 2023 |