Leicester – Confidence in Concept 2019

Lead Research Organisation: University of Leicester

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.

Publications

10 25 50
 
Description Developing a Prototype Artificial Intelligence-based Eye Tracker (A-EYE) for the Diagnosis and Monitoring of Eye Movement Disorders
Amount £14,884 (GBP)
Organisation Fight for Sight 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2020 
 
Description University of Leicester Staff and Student Covid-19 screening programme
Amount £450,000 (GBP)
Organisation University of Leicester 
Sector Academic/University
Country United Kingdom
Start 05/2020 
 
Description Breath sampler for clinical diagnostics and stratified medicine 
Organisation Loughborough University
Country United Kingdom 
Sector Academic/University 
PI Contribution The research team are able to utilise the knowledge and expertise of clinicians and academics within the EMBER consortium - focused on Mass Spectrometer analysis of volatile compounds found in breath. The research team also provide access to patients and patient samples with a broad range of respiratory conditions.
Collaborator Contribution Renfrew Group International (RGi) are an award winning design consultancy company, who provide specific know-how and expertise for innovative product design. RGi have provided design services, electronics manufacturing and rapid prototyping facilities to enable the production of a novel breath collection system. Loughborough University provide access to Mass Spectrometer expertise and equipment complimentary to the expertise in breath analysis at Leicester.
Impact University of Leicester and Renfrew Group engaged in a series of meetings and staff placements (supported by P2D) to establish the feasibility and potential scope of use for a robust novel breath collection system that would provide the ability to offer disposable (sterile) patient contact surfaces, multi channel collection and applicability to normal clinical practice. University of Loughborough, University of Loughborough and Renfrew Group have now produced 3 prototype devices ready to test in a clinical setting. In the process of the project University of Loughborough have contributed £70,000 in funding to the prototype development The project has also benefited from the placement of one of the academic leads into the iCURE commercialisation training programme (estimated £50,000 in-kind contribution) to promote commercial development of the new collection system. The project is in the process of being 'pitched' to a panel of investors through Innovate UK (March 2021) and Mercia Venture Fund (April 2021). (reviewed March 2021 - updated March 2021)
Start Year 2019
 
Description Breath sampler for clinical diagnostics and stratified medicine 
Organisation Renfrew Group International
Country United Kingdom 
Sector Private 
PI Contribution The research team are able to utilise the knowledge and expertise of clinicians and academics within the EMBER consortium - focused on Mass Spectrometer analysis of volatile compounds found in breath. The research team also provide access to patients and patient samples with a broad range of respiratory conditions.
Collaborator Contribution Renfrew Group International (RGi) are an award winning design consultancy company, who provide specific know-how and expertise for innovative product design. RGi have provided design services, electronics manufacturing and rapid prototyping facilities to enable the production of a novel breath collection system. Loughborough University provide access to Mass Spectrometer expertise and equipment complimentary to the expertise in breath analysis at Leicester.
Impact University of Leicester and Renfrew Group engaged in a series of meetings and staff placements (supported by P2D) to establish the feasibility and potential scope of use for a robust novel breath collection system that would provide the ability to offer disposable (sterile) patient contact surfaces, multi channel collection and applicability to normal clinical practice. University of Loughborough, University of Loughborough and Renfrew Group have now produced 3 prototype devices ready to test in a clinical setting. In the process of the project University of Loughborough have contributed £70,000 in funding to the prototype development The project has also benefited from the placement of one of the academic leads into the iCURE commercialisation training programme (estimated £50,000 in-kind contribution) to promote commercial development of the new collection system. The project is in the process of being 'pitched' to a panel of investors through Innovate UK (March 2021) and Mercia Venture Fund (April 2021). (reviewed March 2021 - updated March 2021)
Start Year 2019
 
Description Diagnosis of Covid-19 by MS 
Organisation Waters Corporation
Department Waters Corporation
Country United Kingdom 
Sector Private 
PI Contribution My research group has developed high fidelity MS proteomics techniques applicable to detection of low concentrations of specific peptides.
Collaborator Contribution Waters created a set of research reagents for the generation of peptides from Covid-19 virus particles and an enrichment capture system to enable MS detection of the virus specific peptides. Waters provided access to these research tools free of charge for my research group to evaluate in clinical samples.
Impact Preliminary results show that MS can detect Covid-19 particles in spiked samples, swab samples and in blood. There is a publication in draft at the moment. (Reviewed March 2021 - Updated March 2021)
Start Year 2020
 
Description Myocardial infarction detection and quantification based on Convolution neural network with error correction. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Xin Li gave an oral presentation at the IEEE WORLD CONGRESS ON COMPUTATIONAL INTELLIGENCE (WCCI) 2020, 19 - 24th July, 2020, Glasgow (UK), "Myocardial infarction detection and quantification based on Convolution neural network with error correction."
Year(s) Of Engagement Activity 2020