Manchester – Confidence in Concept 2019
Lead Research Organisation:
University of Manchester
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
People |
ORCID iD |
Publications
Horgan C
(2022)
Current and Future Treatment of Mucopolysaccharidosis (MPS) Type II: Is Brain-Targeted Stem Cell Gene Therapy the Solution for This Devastating Disorder?
in International Journal of Molecular Sciences
Smith TAD
(2022)
Comparison of multiple gene expression platforms for measuring a bladder cancer hypoxia signature.
in Molecular medicine reports
Vitale M
(2022)
Incorporation of Natural and Recombinant Collagen Proteins within Fmoc-Based Self-Assembling Peptide Hydrogels.
in Gels (Basel, Switzerland)
Wood SR
(2022)
Delivering gene therapy for mucopolysaccharide diseases.
in Frontiers in molecular biosciences
| Description | Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy. |
| Amount | € 2,345,625 (EUR) |
| Funding ID | 884952 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 01/2021 |
| End | 12/2025 |
| Description | Wellcome Trust A2E |
| Amount | £25,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | iMATCH |
| Organisation | Innovate UK |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | This project has built upon our pre-clinical data in the MPSII mouse model and takes the treatment a step closer to the clinic. We now have funding through Avrobio to run a clinical trial in 21/22 for 5 patients with MPSII. This treatment could revolutionise the treatment of MPSII. |
| Collaborator Contribution | as aboe |
| Impact | publications |
| Start Year | 2021 |
| Company Name | POLYNERVE LTD |
| Description | Spinout company formed 'Polynerve': currently applying for grant funding to progress to regulatory approvals in US/EU/UK and partner with a manufacturer. |
| Year Established | 2022 |
| Impact | Currently applying for funding |