Manchester – Confidence in Concept 2019

Lead Research Organisation: University of Manchester
Department Name: UNLISTED


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Technical Summary

The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.


10 25 50
Description Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy.
Amount € 2,345,625 (EUR)
Funding ID 884952 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2021 
End 12/2025
Description Wellcome Trust A2E
Amount £25,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Description iMATCH 
Organisation Innovate UK
Country United Kingdom 
Sector Public 
PI Contribution This project has built upon our pre-clinical data in the MPSII mouse model and takes the treatment a step closer to the clinic. We now have funding through Avrobio to run a clinical trial in 21/22 for 5 patients with MPSII. This treatment could revolutionise the treatment of MPSII.
Collaborator Contribution as aboe
Impact publications
Start Year 2021
Description Spinout company formed 'Polynerve': currently applying for grant funding to progress to regulatory approvals in US/EU/UK and partner with a manufacturer. 
Year Established 2022 
Impact Currently applying for funding