MRC Lifecourse Epidemiology Centre - Core Support
Lead Research Organisation:
University of Southampton
Department Name: UNLISTED
Abstract
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Technical Summary
MRC Lifecourse Epidemiology Centre: Technical Summary
Overview
The MRC will use lifecourse epidemiological methods to reduce the population burden of chronic musculoskeletal disease and disability. These approaches will optimize musculoskeletal health (bone, muscle and joint) through the development and testing of lifestyle, behavioural and pharmacological interventions informed by a series of observational studies; and by using these findings to influence health policy.
The specific aims of the MRC Lifecourse Epidemiology Centre will be to:
• Delineate the environmental influences, throughout the lifecourse, of age-related musculoskeletal diseases (osteoporosis, osteoarthritis and sarcopenia).
• Use findings to develop and test population based and targeted interventions to improve musculoskeletal health throughout the lifecourse.
• Maintain and develop the long-term cohorts/trials assembled in Southampton as national and international resources to explore the mechanisms underlying the developmental origins and later causes of musculoskeletal and metabolic health and disease.
• Minimise the adverse impact of musculoskeletal disorders on ability to work, by undertaking a programme running alongside the Versus Arthritis-MRC Centre for Musculoskeletal Health and Work.
• Provide data management and statistical support for a series of preconceptual and pregnancy-based cardiometabolic intervention studies maintained at the fore-running MRC Lifecourse Epidemiology Unit (HeLTI, TALENT, NiPPeR, EACH-B and WRAPPED).
• Inform health policy and promote training, research capacity development, knowledge transfer and public engagement in lifecourse epidemiology.
The aims of the MRC Lifecourse Epidemiology Centre will be delivered through three linked scientific programmes:
1. Musculoskeletal health in later life (PI: Professor Cyrus Cooper)
2. Determinants of musculoskeletal health in the mid-lifecourse (PI: Professor Karen Walker-Bone)
3. Early development and risk of adult musculoskeletal disease (PI: Professor Nicholas Harvey)
Overview
The MRC will use lifecourse epidemiological methods to reduce the population burden of chronic musculoskeletal disease and disability. These approaches will optimize musculoskeletal health (bone, muscle and joint) through the development and testing of lifestyle, behavioural and pharmacological interventions informed by a series of observational studies; and by using these findings to influence health policy.
The specific aims of the MRC Lifecourse Epidemiology Centre will be to:
• Delineate the environmental influences, throughout the lifecourse, of age-related musculoskeletal diseases (osteoporosis, osteoarthritis and sarcopenia).
• Use findings to develop and test population based and targeted interventions to improve musculoskeletal health throughout the lifecourse.
• Maintain and develop the long-term cohorts/trials assembled in Southampton as national and international resources to explore the mechanisms underlying the developmental origins and later causes of musculoskeletal and metabolic health and disease.
• Minimise the adverse impact of musculoskeletal disorders on ability to work, by undertaking a programme running alongside the Versus Arthritis-MRC Centre for Musculoskeletal Health and Work.
• Provide data management and statistical support for a series of preconceptual and pregnancy-based cardiometabolic intervention studies maintained at the fore-running MRC Lifecourse Epidemiology Unit (HeLTI, TALENT, NiPPeR, EACH-B and WRAPPED).
• Inform health policy and promote training, research capacity development, knowledge transfer and public engagement in lifecourse epidemiology.
The aims of the MRC Lifecourse Epidemiology Centre will be delivered through three linked scientific programmes:
1. Musculoskeletal health in later life (PI: Professor Cyrus Cooper)
2. Determinants of musculoskeletal health in the mid-lifecourse (PI: Professor Karen Walker-Bone)
3. Early development and risk of adult musculoskeletal disease (PI: Professor Nicholas Harvey)
Organisations
- University of Southampton (Lead Research Organisation)
- UNIVERSITY OF OXFORD (Collaboration)
- World Health Organization (WHO) (Collaboration)
- University of Manchester (Collaboration)
- University of Sheffield (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- University of Gothenburg (Collaboration)
- University College Dublin (Collaboration)
- University of South Carolina (Collaboration)
- Erasmus University Rotterdam (Collaboration)
- University of Bristol (Collaboration)
Publications
Kanis JA
(2022)
Intervention thresholds and diagnostic thresholds in the management of osteoporosis.
in Aging clinical and experimental research
Kanis JA
(2023)
The need to distinguish intervention thresholds and diagnostic thresholds in the management of osteoporosis.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kanis JA
(2023)
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kankowski L
(2022)
The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review
in Frontiers in Endocrinology
Khalid S
(2021)
Predicting Imminent Fractures in Patients With a Recent Fracture or Starting Oral Bisphosphonate Therapy: Development and International Validation of Prognostic Models.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Khalid S
(2022)
Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kidd SP
(2022)
Reverse-Transcription Loop-Mediated Isothermal Amplification Has High Accuracy for Detecting Severe Acute Respiratory Syndrome Coronavirus 2 in Saliva and Nasopharyngeal/Oropharyngeal Swabs from Asymptomatic and Symptomatic Individuals.
in The Journal of molecular diagnostics : JMD
Kowo-Nyakoko F
(2023)
Evaluation of two methods of bone age assessment in peripubertal children in Zimbabwe.
in Bone
Krstic N
(2022)
Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice.
in Genes & nutrition
Kumar M
(2022)
Population-centric risk prediction modeling for gestational diabetes mellitus: A machine learning approach.
in Diabetes research and clinical practice
Kway YM
(2021)
Automated Segmentation of Visceral, Deep Subcutaneous, and Superficial Subcutaneous Adipose Tissue Volumes in MRI of Neonates and Young Children.
in Radiology. Artificial intelligence
Ladang A
(2023)
Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of
in Calcified tissue international
Laskou F
(2022)
A study of diet in older community-dwelling adults in the UK during the COVID-19 pandemic: Findings from the Southampton Longitudinal Study of Ageing (SaLSA).
in Frontiers in nutrition
Laskou F
(2022)
Functional capacity, sarcopenia, and bone health.
in Best practice & research. Clinical rheumatology
Laskou F
(2022)
Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study.
in Journal of cachexia, sarcopenia and muscle
Laskou F
(2022)
A pas de deux of osteoporosis and sarcopenia: osteosarcopenia.
in Climacteric : the journal of the International Menopause Society
Lau HX
(2021)
Role of maternal tryptophan metabolism in allergic diseases in the offspring.
in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Lee YQ
(2022)
Tracking of dietary patterns between pregnancy and 6 years post-pregnancy in a multiethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study.
in European journal of nutrition
Lems WF
(2021)
Vertebral fracture: epidemiology, impact and use of DXA vertebral fracture assessment in fracture liaison services.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Leyland KM
(2021)
Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data.
in Aging clinical and experimental research
Lim IY
(2022)
Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome.
in The Journal of clinical endocrinology and metabolism
Lim SX
(2021)
Identification and reproducibility of dietary patterns assessed with a FFQ among women planning pregnancy.
in Public health nutrition
Lim SX
(2022)
Prepregnancy adherence to plant-based diet indices and exploratory dietary patterns in relation to fecundability.
in The American journal of clinical nutrition
Loo EXL
(2021)
Cohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO).
in European journal of epidemiology
Loo EXL
(2021)
House dust mite sensitization, eczema, and wheeze increase risk of shellfish sensitization.
in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Loy SL
(2022)
Metabolic health status and fecundability in a Singapore preconception cohort study.
in American journal of obstetrics and gynecology
Loy SL
(2021)
Influence of red blood cell indices on HbA1c performance in detecting dysglycaemia in a Singapore preconception cohort study.
in Scientific reports
Loy SL
(2021)
Fecundability in reproductive aged women at risk of sexual dysfunction and associated risk factors: a prospective preconception cohort study.
in BMC pregnancy and childbirth
McCloskey E
(2021)
Short time horizons for fracture prediction tools: time for a rethink
in Osteoporosis International
McCloskey EV
(2022)
Population screening for fracture risk in postmenopausal women - a logical step in reducing the osteoporotic fracture burden?
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Mensink-Bout SM
(2022)
Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children.
in The European respiratory journal
Mitchell PJ
(2022)
Quality improvement initiatives in the care and prevention of fragility fractures in the Asia Pacific region.
in Archives of osteoporosis
Moon R
(2024)
Feldman and Pike' s Vitamin D
Moon RJ
(2021)
The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial.
in Therapeutic advances in musculoskeletal disease
Moon RJ
(2023)
Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial.
in Journal of public health (Oxford, England)
Moon RJ
(2023)
Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study.
in The Journal of clinical endocrinology and metabolism
Moon RJ
(2022)
Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D.
in The Journal of clinical endocrinology and metabolism
Moon RJ
(2022)
Is the skull responsive to bone mineralisation stimuli in children?
in Bone
Moon RJ
(2023)
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Morris TT
(2021)
Consistency of noncognitive skills and their relation to educational outcomes in a UK cohort.
in Translational psychiatry
Murray R
(2021)
Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years.
in Hypertension (Dallas, Tex. : 1979)
NCD Risk Factor Collaboration (NCD-RisC)
(2023)
Diminishing benefits of urban living for children and adolescents' growth and development.
in Nature
NCD Risk Factor Collaboration (NCD-RisC)
(2021)
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight.
in eLife
Nevola KT
(2021)
Pharmacogenomic Effects of ß-Blocker Use on Femoral Neck Bone Mineral Density.
in Journal of the Endocrine Society
Nonterah EA
(2022)
Children born during the hunger season are at a higher risk of severe acute malnutrition: Findings from a Guinea Sahelian ecological zone in Northern Ghana.
in Maternal & child nutrition
Ong J
(2021)
Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study
in BMC Pregnancy and Childbirth
Description | European guidance on very high fracture risk (NCH, CC) |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | National Osteoporosis Guideline Group Advisory Committee (NCH, CC) |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture |
Amount | £36,000 (GBP) |
Organisation | University of Southampton |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2022 |
End | 09/2025 |
Description | Preventing broken bones in older people: from research to policy to practice |
Amount | £29,566 (GBP) |
Funding ID | MRF-145-0011-DG-HARV-C0913 |
Organisation | Medical Research Council (MRC) |
Department | Medical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 09/2022 |
Description | UKRI WCL Capital funding 2020 2021 DXA and MSK Scanning Suite |
Amount | £216,857 (GBP) |
Funding ID | 4050801857 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2020 |
End | 03/2021 |
Title | Novel seasonal adjustment for vitamin D concentrations |
Description | Novel method for adjusting the vitamin D concentrations for season, independent of assays used. |
Type Of Material | Model of mechanisms or symptoms - human |
Provided To Others? | No |
Impact | Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation. Moon RJ, Crozier SR, Dennison EM, Davies JH, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Harvey NC. Am J Clin Nutr. 2015 Nov;102(5):1081-7. doi: 10.3945/ajcn.115.115295. |
Description | ALPHABET |
Organisation | Erasmus University Rotterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | National Institute of Health and Medical Research (INSERM) |
Department | Center for Epidemiological and Bio Statistics Research at Sorbonne |
Country | France |
Sector | Public |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | University College Dublin |
Department | School of Physics |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | University College Dublin |
Country | Ireland |
Sector | Academic/University |
PI Contribution | WP5, bone outcomes |
Collaborator Contribution | Consortium |
Impact | Ongoing |
Start Year | 2017 |
Description | ALPHABET |
Organisation | University of Bristol |
Department | Biomedical Research Unit in Nutrition, Diet and Lifestyle |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | WP5, bone outcomes |
Collaborator Contribution | Consortium |
Impact | Ongoing |
Start Year | 2017 |
Description | ALPHABET |
Organisation | University of South Carolina |
Department | Arnold School of Public Health |
Country | United States |
Sector | Academic/University |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALSPAC placenta |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Placental determinants of bone mass |
Collaborator Contribution | Placental determinants of bone mass |
Impact | Ongoing |
Start Year | 2013 |
Description | AUGMENT UK Biobank collaboration |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | AUGMENT UK Biobank collaboration |
Collaborator Contribution | AUGMENT UK Biobank collaboration |
Impact | AUGMENT UK Biobank collaboration |
Start Year | 2017 |
Description | AUGMENT UK Biobank collaboration |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | AUGMENT UK Biobank collaboration |
Collaborator Contribution | AUGMENT UK Biobank collaboration |
Impact | AUGMENT UK Biobank collaboration |
Start Year | 2017 |
Description | MAVIDOS Childhood Follow up |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Recruitment to MAVIDOS 6 year follow-up in Sheffield |
Collaborator Contribution | Recruitment to MAVIDOS six-year follow-up in Sheffield |
Impact | N/A |
Start Year | 2016 |
Description | MAVIDOS Childhood Follow-up Oxford |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Recruitment of children to MAVIDOS six-year follow-up in Oxford |
Collaborator Contribution | Recruitment of children to MAVIDOS six-year follow-up in Oxford |
Impact | N/A |
Start Year | 2016 |
Description | MAVIDOS Oxford CVD |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Vitamin D in pregnancy and offspring cardiac structure and function |
Collaborator Contribution | Vitamin D in pregnancy and offspring cardiac structure and function |
Impact | Ongoing |
Start Year | 2015 |
Description | SARCOFRAX |
Organisation | University of Gothenburg |
Country | Sweden |
Sector | Academic/University |
PI Contribution | Developing sarcopenia outcome risk calculator |
Collaborator Contribution | Developing sarcopenia outcome risk calculator |
Impact | ongoing |
Start Year | 2020 |
Description | SARCOFRAX |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developing sarcopenia outcome risk calculator |
Collaborator Contribution | Developing sarcopenia outcome risk calculator |
Impact | ongoing |
Start Year | 2020 |
Description | WHO Clinical Consortium on Health Ageing |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Contribution to World Report on Ageing and Health, and project to operationalise concept of intrinsic capacity |
Collaborator Contribution | Organisation of WHO workshop on intrinsic capacity |
Impact | WHO Global Report on Ageing and Health |
Start Year | 2016 |
Title | PHENOTYPE PREDICTION BY DETERMINING THE METHYLATION STATUS OF GENES |
Description | Phenotypic characteristics selected from obesity and/or adiposity, bone health, and cardiovascular disease, may be predicted by determining the methylation status of one or more CpG dinucleotides of the, SLC6A4, CDKN2A, FEN1 and BACH1 genes. |
IP Reference | WO2015067952 |
Protection | Patent application published |
Year Protection Granted | 2015 |
Licensed | No |
Impact | EpiGen Consortium |
Title | PREDICTIVE USE OF CPG METHYLATION |
Description | RXRA for obesity or adiposity, body mass index and limb fat as an indicator of body fat distribution |
IP Reference | EP2391730 |
Protection | Patent application published |
Year Protection Granted | 2011 |
Licensed | No |
Impact | EpiGen Consortium |
Title | Phenotype prediction |
Description | Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual. |
IP Reference | EP2194143 |
Protection | Patent application published |
Year Protection Granted | 2010 |
Licensed | No |
Impact | EpiGen Consortium |
Description | ESCEO Working Group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus Cooper attended the ESCEO Working Group on September 9th 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Launch of the MRC Lifecourse Epidemiology Centre & MRC National Musculoskeletal Group |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | The launch of the MRC Lifecourse Epidemiology Centre and the MRC National Musculoskeletal Ageing Network was an online event. |
Year(s) Of Engagement Activity | 2022 |
URL | https://us06web.zoom.us/rec/play |
Description | Presentation given at ESCEO Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus gave a presentation entitled "Optamising the prescription of oral Bisphosphonates" |
Year(s) Of Engagement Activity | 2022 |
Description | REF 2021 University Results Presentation |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus attended the REF2021 University Results Presentation meeting on 9th May 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Southampton Women's Survey Celebration Event |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | As part of the 50th Anniversary of the NIHR BRC, the Southampton Women's Survey were chosen to represent some of the research that has taken place in Southampton. The BRC funded an evening at the City Art Gallery in Southampton for 50 SWS participants and their family or friends. The speakers who talked about the study findings were Prof. Cyrus Copper, Prof Keith Godfrey, Prof Janis Baird and Prof Hazel Inskip who wrote and sang a song at the end of the presentation whilst playing her ukulele. SWS staff in attendance and who organised the logistics for the event were research nurses, Julia Hammond, Nicole Minette, Karen McGill and Tina Horsfall. They received requests about further participation or involvement, the audience reported change in views, opinions or behaviours, requests for further information. Children were also recruited for PPI for the BRC. |
Year(s) Of Engagement Activity | 2022 |