Establishment of a National Network on Musculoskeletal Ageing
Lead Research Organisation:
University of Southampton
Department Name: UNLISTED
Abstract
Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government “Grand Challenge” target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.
Technical Summary
Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government “Grand Challenge” target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.
People |
ORCID iD |
Cyrus Cooper (Principal Investigator) |
Publications
Kanis JA
(2023)
Adjusting conventional FRAX estimates of fracture probability according to the number of prior falls in the preceding year.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kanis JA
(2022)
Adjusting conventional FRAX estimates of fracture probability according to the number of prior fractures.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kanis JA
(2022)
Intervention thresholds and diagnostic thresholds in the management of osteoporosis.
in Aging clinical and experimental research
Kanis JA
(2023)
Primary hyperparathyroidism and fracture probability.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kanis JA
(2023)
The need to distinguish intervention thresholds and diagnostic thresholds in the management of osteoporosis.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kanis JA
(2023)
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Khalid S
(2022)
Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Kline GA
(2023)
General Comorbidity Indicators Contribute to Fracture Risk Independent of FRAX: Registry-Based Cohort Study.
in The Journal of clinical endocrinology and metabolism
Kowo-Nyakoko F
(2023)
Evaluation of two methods of bone age assessment in peripubertal children in Zimbabwe.
in Bone
Krstic N
(2022)
Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice.
in Genes & nutrition
Ladang A
(2023)
Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of
in Calcified tissue international
Laskou F
(2022)
Relationships Between Muscle Parameters and History of Falls and Fractures in the Hertfordshire Cohort Study: Do All Muscle Components Relate Equally to Clinical Outcomes?
in Calcified tissue international
Laskou F
(2022)
Functional capacity, sarcopenia, and bone health.
in Best practice & research. Clinical rheumatology
Laskou F
(2022)
A study of diet in older community-dwelling adults in the UK during the COVID-19 pandemic: Findings from the Southampton Longitudinal Study of Ageing (SaLSA).
in Frontiers in nutrition
Leslie W
(2022)
FREM predicts 10-year incident fracture risk independent of FRAX® probability: a registry-based cohort study
in Osteoporosis International
Leslie WD
(2022)
The Effect of Fracture Recency on Observed 10-Year Fracture Probability: A Registry-Based Cohort Study.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Leslie WD
(2022)
Effect of Discordant Hip Bone Density on Incident Fracture Risk: A Registry-Based Cohort Study.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Lorentzon M
(2022)
Menopausal hormone therapy reduces the risk of fracture regardless of falls risk or baseline FRAX probability-results from the Women's Health Initiative hormone therapy trials.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Lyons-Reid J
(2022)
Cross-calibration of two dual-energy X-ray absorptiometry devices for the measurement of body composition in young children.
in Scientific reports
McCloskey E
(2022)
Trabecular Bone Score Adjustment for the Fracture Risk Assessment Tool (FRAX®).
in Calcified tissue international
McCloskey EV
(2022)
Population screening for fracture risk in postmenopausal women - a logical step in reducing the osteoporotic fracture burden?
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Moon R
(2024)
Feldman and Pike' s Vitamin D
Moon RJ
(2022)
Is the skull responsive to bone mineralisation stimuli in children?
in Bone
Moon RJ
(2023)
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Moon RJ
(2023)
Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial.
in Journal of public health (Oxford, England)
Moon RJ
(2022)
Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D.
in The Journal of clinical endocrinology and metabolism
Moon RJ
(2023)
Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study.
in The Journal of clinical endocrinology and metabolism
NCD Risk Factor Collaboration (NCD-RisC)
(2023)
Diminishing benefits of urban living for children and adolescents' growth and development.
in Nature
Parsons CM
(2022)
Assessment of Activity Profiles in Older Adults and Lower Limb Bone Parameters: Observations from the Hertfordshire Cohort Study.
in Calcified tissue international
Pinedo-Villanueva R
(2023)
Expected Benefits and Budget Impact From a Microsimulation Model Support the Prioritization and Implementation of Fracture Liaison Services.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Pinto D
(2022)
The global approach to rehabilitation following an osteoporotic fragility fracture: A review of the rehabilitation working group of the International Osteoporosis Foundation (IOF) committee of scientific advisors.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Raisi-Estabragh Z
(2022)
Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank.
in Heart (British Cardiac Society)
Raisi-Estabragh Z
(2022)
Estimation of biological heart age using cardiovascular magnetic resonance radiomics.
in Scientific reports
Raisi-Estabragh Z
(2023)
Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer.
in Heart (British Cardiac Society)
Raisi-Estabragh Z
(2023)
Incident Clinical and Mortality Associations of Myocardial Native T1 in the UK Biobank.
in JACC. Cardiovascular imaging
Raisi-Estabragh Z
(2023)
Lower birth weight is linked to poorer cardiovascular health in middle-aged population-based adults.
in Heart (British Cardiac Society)
Raisi-Estabragh Z
(2022)
Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study.
in European heart journal. Cardiovascular Imaging
Rambukwella R
(2023)
Hospital admissions and mortality over 20 years in community-dwelling older people: findings from the Hertfordshire Cohort Study.
in Aging clinical and experimental research
Remfry E
(2023)
Sex-based differences in risk factors for incident myocardial infarction and stroke in the UK Biobank.
in European heart journal. Quality of care & clinical outcomes
Saleh YAL
(2022)
Incidence of hip fracture in Saudi Arabia and the development of a FRAX model.
in Archives of osteoporosis
Salih AM
(2023)
Image-Based Biological Heart Age Estimation Reveals Differential Aging Patterns Across Cardiac Chambers.
in Journal of magnetic resonance imaging : JMRI
Shaw S
(2023)
Influences of the community and consumer nutrition environment on the food purchases and dietary behaviors of adolescents: A systematic review.
in Obesity reviews : an official journal of the International Association for the Study of Obesity
Sing CW
(2023)
Global Epidemiology of Hip Fractures: Secular Trends in Incidence Rate, Post-Fracture Treatment, and All-Cause Mortality.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Skjødt MK
(2024)
Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Skjødt MK
(2023)
Healthcare costs associated with opportunistically identifiable vertebral fractures.
in Bone
Description | European guidance on very high fracture risk (NCH, CC) |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | National Osteoporosis Guideline Group Advisory Committee (NCH, CC) |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture |
Amount | £36,000 (GBP) |
Organisation | University of Southampton |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2022 |
End | 09/2025 |
Description | Preventing broken bones in older people: from research to policy to practice |
Amount | £29,566 (GBP) |
Funding ID | MRF-145-0011-DG-HARV-C0913 |
Organisation | Medical Research Council (MRC) |
Department | Medical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 09/2022 |
Description | AUGMENT UK Biobank collaboration |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | AUGMENT UK Biobank collaboration |
Collaborator Contribution | AUGMENT UK Biobank collaboration |
Impact | AUGMENT UK Biobank collaboration |
Start Year | 2017 |
Description | AUGMENT UK Biobank collaboration |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | AUGMENT UK Biobank collaboration |
Collaborator Contribution | AUGMENT UK Biobank collaboration |
Impact | AUGMENT UK Biobank collaboration |
Start Year | 2017 |
Description | Abstract Writing Masterclass |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Nick Harvey presented the MRC National Musculoskeletal Ageing Network abstract writing seminar, which took place on December 13th 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Article written by Nick Harvey in UoS Enews |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Nick Harvey wrote an article for the University of Southampton Enews in which he wrote about the welcome return to face-face- meetings; the opportunity for in-person participation in the American Society for Bone and Mineral Research Annual Scientific Conference in Austin, Texas and to be able to catch up with colleagues and friends from all over the world. He also mentioned that the new term brings progression of a major initiative in UK musculoskeletal science with the consolidation of the strategic framework for our UKRI MRC National Musculoskeletal Ageing Network. The network will be led by the University of Southampton. He also added that it was great to see the exciting news of the UK Biobank Repeat Imaging Study recently made public. |
Year(s) Of Engagement Activity | 2022 |
Description | ESCEO Working Group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus Cooper attended the ESCEO Working Group on September 9th 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Gestational vitamin D supplementation: observation mechanism and intervention in the MAVIDOS trial. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Nick Harvey gave a talk at the BSR Science Forum on 18th February 2022. Up to 50 people attended. |
Year(s) Of Engagement Activity | 2022 |
Description | Launch of the MRC Lifecourse Epidemiology Centre & MRC National Musculoskeletal Group |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | The launch of the MRC Lifecourse Epidemiology Centre and the MRC National Musculoskeletal Ageing Network was an online event. |
Year(s) Of Engagement Activity | 2022 |
URL | https://us06web.zoom.us/rec/play |
Description | Lay presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Nick Harvey delivered a lay presentation on Osteoporosis to the Patient Partner Group at the St Francis Surgery in Hedge End, Southampton. Around 100 people attended. |
Year(s) Of Engagement Activity | 2023 |
Description | Presentation given at ESCEO Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus gave a presentation entitled "Optamising the prescription of oral Bisphosphonates" |
Year(s) Of Engagement Activity | 2022 |
Description | Press Release and publication of paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Press release for the paper entitled "Is the skull responsive to bone mineralisation stimuli in children? published in the journal Bone. There was some media attention following the publication of this paper. The press release was entitled "Skulls stay strong despite worse diets" |
Year(s) Of Engagement Activity | 2022 |
Description | Press Release of published paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | There were a number of online citings following a press release entitled "Three coffees a day could help keep the doctor away." This was to do with an article published in European Journal of Preventive Cardiology entitled: Light to moderated coffee consumption is associated with lower risk of death: UK Biobank Study. Simon J, Fung K, et al. |
Year(s) Of Engagement Activity | 2022 |
Description | Preventing broken bones in older people: from research to policy to practice |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | The University Faculty of Medicine print a Research Roundup Newsletter. These newsletters aim to celebrate success, provide research updates and give information on upcoming opportunities. The second of these newsletters was written by Professor Nick Harvey. |
Year(s) Of Engagement Activity | 2022 |
Description | REF 2021 University Results Presentation |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus attended the REF2021 University Results Presentation meeting on 9th May 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Southampton Women's Survey Celebration Event |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | As part of the 50th Anniversary of the NIHR BRC, the Southampton Women's Survey were chosen to represent some of the research that has taken place in Southampton. The BRC funded an evening at the City Art Gallery in Southampton for 50 SWS participants and their family or friends. The speakers who talked about the study findings were Prof. Cyrus Copper, Prof Keith Godfrey, Prof Janis Baird and Prof Hazel Inskip who wrote and sang a song at the end of the presentation whilst playing her ukulele. SWS staff in attendance and who organised the logistics for the event were research nurses, Julia Hammond, Nicole Minette, Karen McGill and Tina Horsfall. They received requests about further participation or involvement, the audience reported change in views, opinions or behaviours, requests for further information. Children were also recruited for PPI for the BRC. |
Year(s) Of Engagement Activity | 2022 |
Description | University of Southampton Science and Engineering Day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Nick Harvey was part of a team from the MRC LEU that took part in this event. The event was well attended with members of the public showing great interest. |
Year(s) Of Engagement Activity | 2022 |
Description | WCO-IOF-ESCEO Conference - Virtual |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Nick Harvey, Deputy Director of MRC LEU gave the Plenary Lecture 2 entitled 'Update of the management of patients at imminent fracture risk at the WCO-IOF-ESCEO conference on 24th March 2022, which was held virtually. This was attended by over 1,000 people. |
Year(s) Of Engagement Activity | 2022 |