Mary Lyon Centre, International Facility for Mouse Genetics, at MRC Harwell
Lead Research Organisation:
MRC Harwell Institute
Department Name: UNLISTED
Abstract
The Mary Lyon Centre provides both scientific and technical services for UK researchers needing to use the mouse to study the impact of genes on human health. The portfolio of services include generating new mouse strains which have genes altered in a way that is either the same as seen in humans with disease or will inform scientists on the function of that gene. We have a large team of experienced animal care workers who focus on the care of our animals, ensuring that any welfare concerns are attended to and that we only breed the minimum numbers needed for the researcher. The Mary Lyon Centre is also the central hub of the National Mouse Genetics Network, a consortia of many laboratories using the mouse to understand and develop therapies for diseases such as cancer and neurological disorders. A significant proportion of our work is targeted towards training and disseminating best practice in genetics research and integrity in laboratory animal science.
Technical Summary
The mouse remains the model organism of choice for many genetic studies. With the onset of large scale genomic studies such as Genomics England and the increased drive for more standardised and robust experiments involving laboratory animals, the Mary Lyon Centre (MLC) offers high quality and accessible services in mouse genetics to the UK Biomedical community. The MLC is a state of the art animal facility with specific pathogen free (SPF) health status which provides animal care and technical services for in excess of 50k mice at any one time. In doing so, it supports the research of the National Mouse Genetics Network as well as many academic and commercial partners.
The MLC is operationally divided into 4 departments: • Husbandry and Phenotyping (animal husbandry, phenotyping, technical support, facilities management) • Biological Resources (line generation, archiving and dissemination of genetically altered (GA) lines • Molecular and Cellular Biology (design, preparation, quality control of genomic alteration; expression studies and developmental imaging) • Training (offering taught practical and theory course from the Advance training centre) . Although animal care and welfare is at the centre of the MLC service, we have extended the support we offer to researchers using laboratory animals by providing extensive technical and scientific expertise in laboratory animal science. Our intention is to provide science-led service delivery, developing and improving scientific and technical laboratory animal services within a culture of animal care. The great advantage of a unit the size of the MLC is that at any one time we retain the critical mass of trained and skilled personnel to be able to sustain a continuous service to our users. The collective experience and training of the MLC staff means that it is able to offer proficient, effective and well performed animal procedures, thereby ensuring good animal welfare and efficient animal use. Involvement in national and international activities and training: We believe that good animal science can only be done in close collaboration with other institutes and organisations, giving us exposure to new practices and benchmarking opportunities. We also recognise that as a mature facility, with a team containing significant expertise and experience, we have a considerable amount to offer the animal science community. To this end, the senior management team of the MLC are involved in many national and international committees and groups. In addition, MLC staff frequently act in an advisory capacity, within their specialist areas, to new facilities or services or those under review. Furthermore, as the use of mouse models has become more sophisticated and complex, MLC staff have become increasingly involved in training and organisations such as the Wellcome Trust, EMMA, NC3Rs and RSPCA which have looked to Harwell for expertise and leadership. The commitment to these activities involves a significant amount of staff time and resources. Moreover, we plan to continue to extend our influence and involvement in UK animal science in the coming years, especially in the areas of the 3Rs, legislative control, pathology, archiving and dissemination of mouse lines and training in mouse genetics.
The MLC is operationally divided into 4 departments: • Husbandry and Phenotyping (animal husbandry, phenotyping, technical support, facilities management) • Biological Resources (line generation, archiving and dissemination of genetically altered (GA) lines • Molecular and Cellular Biology (design, preparation, quality control of genomic alteration; expression studies and developmental imaging) • Training (offering taught practical and theory course from the Advance training centre) . Although animal care and welfare is at the centre of the MLC service, we have extended the support we offer to researchers using laboratory animals by providing extensive technical and scientific expertise in laboratory animal science. Our intention is to provide science-led service delivery, developing and improving scientific and technical laboratory animal services within a culture of animal care. The great advantage of a unit the size of the MLC is that at any one time we retain the critical mass of trained and skilled personnel to be able to sustain a continuous service to our users. The collective experience and training of the MLC staff means that it is able to offer proficient, effective and well performed animal procedures, thereby ensuring good animal welfare and efficient animal use. Involvement in national and international activities and training: We believe that good animal science can only be done in close collaboration with other institutes and organisations, giving us exposure to new practices and benchmarking opportunities. We also recognise that as a mature facility, with a team containing significant expertise and experience, we have a considerable amount to offer the animal science community. To this end, the senior management team of the MLC are involved in many national and international committees and groups. In addition, MLC staff frequently act in an advisory capacity, within their specialist areas, to new facilities or services or those under review. Furthermore, as the use of mouse models has become more sophisticated and complex, MLC staff have become increasingly involved in training and organisations such as the Wellcome Trust, EMMA, NC3Rs and RSPCA which have looked to Harwell for expertise and leadership. The commitment to these activities involves a significant amount of staff time and resources. Moreover, we plan to continue to extend our influence and involvement in UK animal science in the coming years, especially in the areas of the 3Rs, legislative control, pathology, archiving and dissemination of mouse lines and training in mouse genetics.
Organisations
- MRC Harwell Institute (Lead Research Organisation)
- UK HEALTH SECURITY AGENCY (Collaboration)
- Foundation for Prader-Willi Research (FPWR) (Collaboration)
- DIAMOND LIGHT SOURCE (Collaboration)
- University of Dundee (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- University of Sheffield (Collaboration)
- Science and Technologies Facilities Council (STFC) (Collaboration)
- THE PIRBRIGHT INSTITUTE (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Rosalind Franklin Institute (Collaboration)
- University of Bristol (Collaboration)
People |
ORCID iD |
| Sara Wells (Principal Investigator) |
Publications
Akula SK
(2023)
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
in Proceedings of the National Academy of Sciences of the United States of America
Bai Y
(2023)
Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Cacheiro P
(2022)
Mendelian gene identification through mouse embryo viability screening.
in Genome medicine
Caulder A
(2022)
Presenting the genotyping services at the Mary Lyon Centre at MRC Harwell; a high-throughput mouse genotyping pipeline
in Transgenic Research
Chee JM
(2023)
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
in BMC biology
Cheng C
(2022)
Early embryonic lethality in complex I associated p.L104P Nubpl mutant mice
in Orphanet Journal of Rare Diseases
Fower A
(2022)
Genome editing mice for medicine: generating and distributing in vivo mouse models of human disease for developing therapeutic strategies
in Transgenic Research
Groza T
(2023)
The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease.
in Nucleic acids research
Hannan F
(2022)
Hypercalcaemic mice harbouring a germline ablation of G-protein subunit alpha-11 have anaemia that is corrected by treatment with erythropoietin
in Endocrine Abstracts
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UP_2201/1 | 01/04/2022 | 31/03/2027 | £29,145,137 | ||
| MC_UP_2201/2 | Transfer | MC_UP_2201/1 | 01/04/2022 | 31/03/2027 | £3,403,200 |
| MC_UP_2201/3 | Transfer | MC_UP_2201/2 | 01/04/2022 | 31/03/2027 | £2,116,432 |
| Description | Animal Science Group |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Examines issues around animla research |
| URL | https://www.rsb.org.uk/policy/groups-and-committees/asg |
| Description | DTP- GW4 |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Training GW4 students |
| Description | Discussions across national interest parties - NA3Rs/COST |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to new or improved professional practice |
| Impact | Improved 3Rs dissemination |
| Description | Membership of KTN for Microbiome |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | Improved dissemination of national infrastructures |
| URL | https://iuk.ktn-uk.org/agrifood/microbiome/ |
| Description | Opinion in Trends in Genetics |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Opinion of Standards for validation of animal models generated by genome editing |
| URL | https://www.sciencedirect.com/science/article/pii/S016895252030247X |
| Description | Participation in COST -Action: CA211139 IMPROVE |
| Geographic Reach | Europe |
| Policy Influence Type | Contribution to new or improved professional practice |
| URL | https://www.cost.eu/actions/CA21139/ |
| Description | Using both sexes |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Working group on inclusion of both sexes in experimental design |
| URL | https://www.ukri.org/councils/mrc/guidance-for-applicants/policies-and-guidance-for-researchers/sex-... |
| Description | Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data. |
| Amount | $6,945,466 (USD) |
| Funding ID | 2UM1HG006370-11 |
| Organisation | National Human Genome Center; Howard University |
| Sector | Academic/University |
| Country | United States |
| Start | 09/2022 |
| End | 08/2027 |
| Description | Solve-rd |
| Amount | € 20,000 (EUR) |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | 08/2021 |
| End | 07/2023 |
| Title | 10 x shipments of strains expressing Cre recombinase under control of ERT2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 12 x shipments of strains carrying conditional allele |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 129SvJ.Cg-Tg(Th-ALK*F1174L)2Loch/ICR |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 129SvJ.Cg-Tg(Th-MYCN)41Waw/ICR |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 19 x shipments of strains carrying CRISPR/Cas9 generated null alleles |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x import shipments - C57BL/6JEiJ ND6-P25L |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x import shipments -C57Bl/6J-mt-tA m.A5019G |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x import shipments -C57Bl/6J-mt-tA m.A5019G |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x import shipments -Cys421Ser/Cys424Ser RSK1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 2 x import shipments -Pdx1-Cre; LSL-KRas |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x import shipments -mt-Ta |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x shipments sent out - B6.cerox1-Exon2CRISPR KO/J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x shipments sent out - C57BL/6J-Acan |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 2 x shipments sent out - C57BL/6J-Htra1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 2 x shipments sent out - CHRX-DEL57KB-EM1-B6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x shipments sent out - MYLK3-RS-EM1-B6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x shipments sent out - PN dKO PGC-ESC F8 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 2 x shipments sent out - Vangl2flox |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 24 x shipment of wildtype mouse strains |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 27 x shipment of strains carrying an IKMC knockout-first allele |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 3 x shipments sent out - CD1; B6D2-Tg(Prm1-EGFP)#Ltku/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 5 x import shipments of wildtype mice |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 5 x shipments of strains carrying an ENU induced point mutation |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 5 x shipments of strains carrying an IKMC null allele |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 7 x shipments sent out - CCPG1OS-DEL321-EM1-B6N |
| Description | Facilities Research - Import |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 8HUM, Rag2 KO, IL2 KO |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | 8HUM_IL2 KO |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | APTX |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | ATX-DGK |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | ATX-GK-B6N |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | ATX-K |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | ATX-L4 |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | ATX-dG |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | ATX-pGK |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | AZ-LILRB2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Abca12 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | AhCre |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Mouse models |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | AppKI(AppNL.G.F) x C57BL/6J.129P2-Dp(16Mis18a-Runx1)2TybEmcf |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Arl15-INDEL-CAS-B6N |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Arl15-INDEL-CAS-B6N |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Atp2b2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6(Cg)-Chd8tm1.2Mabn/H |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6(D2)-TardbpRgsc2223/RgscH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6(SJL)-Tardbp |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | B6-Cg-Sdhb |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6-Nlrp3tm1.1Aztc |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | B6-Nlrp3tm1.1Aztc |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | B6.129-S100A10tm1Jnw/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.129-Sod1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.129P2-Cxcl12 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | B6.129S6-Dp(16Cbr1-Fam3b)1Rhr/NimrH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6.Cg-Ddx5 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.Cg-Ndrg1 |
| Description | Mouse model |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.Cg-Tg(Cdh5-cre)1Spe/J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | B6.cerox1-Exon2CRISPR KO/J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6;129-Tardbp |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;129P2-Anxa6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;129P2-Ccr9 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6;129P2-Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;129X1-Chm |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;CBACa-Tg(PMP22)C22Clh/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;Cg-Fus |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6J(D2)-Tardbp |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6J.129-Siglec1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6J.129P2-Ercc6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6J.B6N-C9orf72 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | B6J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6JFVBF1-3p del |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Brca2M |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C17S PKA RIa |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C195S PKG |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C230A EPHX 2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H.Cg-Ankrd11 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H/HeH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export (second) |
| URL | http://www.mousebook.org |
| Title | C3H/HeH-Pkhd1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H101H-Dp(15)5H/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | C3H101H-Pax3 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H101HF1 x STOCK Dp(14)2H/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | C57BL/6-App |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | C57BL/6-Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-Hlf tm1Yoko |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6-SpastinN384K knock-in |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-Tg(Cdh5-cre/ERT2)1Rha |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-Zfp382 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-App |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Cx3cr1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Rock1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Taf1em2Ems/Mmjax |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6J-Tg(Bmx-cre/ERT2)1Rha |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Zfp667 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J.129P2-Dp(16Dyrk1a-B3galt5)5TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | C57BL/6J.129P2-Dp(16Igsf5-Zbtb21)6TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6J.129P2-Dp(16Lipi-Hunk)9TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J.129P2-Dp(16Mir802-Dscr3)4TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6J.129P2-Dp(16Mir802-Zbtb21)3TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6J.129P2-Dp(16Mis18a-Runx1)2TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6J.129P2-Dp(16lfnar1-Runx1)8TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6JNimr.129P2-Dp(16Mis18a-Il10rb)7TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6N-A |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6N-Gpx3 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6N-Rgl3 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6NTac-Cd276tm718(CD276)/Tac |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57BL/6NTac-Cx3cl1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6NTac-Grb10em1H/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57Bl/6J-mt-tA m.A5019G |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | C57Bl/6N PolGY933C |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | CCR2-DEL938-EM1-B6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | CD19(cre/wt); EZH2(Y641F/wt) |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | CD19(cre/wt); EZH2(Y641F/wt) |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | CD19(cre/wt); EZH2(fl/fl) |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Clic1-EM2-DEL |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Cys42Ser PKG1a |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Cys436Ser/Cys439Ser RSK2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Cys564Gly Rsk1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | DBA.Cg-Fus |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Del(10Map3k5-Map7)2Kcl/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Del(18Ctxn3-Ccdc192)1Kcl/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Espn |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Ezh2(fl/fl), Nes-CreERT2/+ |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | FUS-DELTA-DBA-B6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | FVB-Tg(ARR2/Pbsn-MYC)7Key/Nci |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | GldcGT1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Grk1-SaCas9-B6J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | H11tm1(Cag mCherry, Top1g1)Jtu |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | H3.3K27M/wt |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | HNF1A-FLOX-EM1-B6N |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Hes7-CRE |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Hprt |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Hprttm1(CAG-mCherry Top1)Jtu |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Lck-LMO2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | MPC1 tetO KI |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | MPC2 tetO KI |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | MRP-14 (S100a9 - /-) |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mll-AF4 invertor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mll3-flox/Mll3-flox; Nf1-flox/Nf1-flox; Mx1-Cre/+ |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mybbp1a f/f Mx1-Cre |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | NCX1 Flox C770A |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | NCX1 Flox C770A |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | NFASC-P694T-EM1-B6N |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Nkx2.2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Nphs2pod.T2A.ciCre.T2A.mTomato |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | PLP-GalNAc T-CFP |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Pcdh15 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Polgtm1.1Lrsn |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Pten-R173C |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Publication of a research article involving clinical chemistry carried out on mouse samples at MRC Harwell |
| Description | Publication of article "Dystrophin myonuclear domain restoration governs treatment efficacy in dystrophic muscle" in Proceedings of the National Academy of Sciences USA, describing clinical chemistry carried out on mouse samples at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to have clinical chemistry carried out on samples from experimental mice at the MLC. |
| URL | https://www.pnas.org/doi/abs/10.1073/pnas.2206324120?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org... |
| Title | Publication of a research article involving clinical chemistry carried out on mouse samples at MRC Harwell |
| Description | Publication of article "Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-Like Autoimmunity" in the Journal of Immunology, describing clinical chemistry carried out on mouse samples at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to have clinical chemistry carried out on samples from experimental mice at the MLC. |
| URL | https://journals.aai.org/jimmunol/article/210/5/547/237656/Prolidase-Deficiency-Causes-Spontaneous-T... |
| Title | Publication of a research article involving mice derived from frozen sperm obtained from MRC Harwell |
| Description | Publication of article "GOT1 constrains T(H)17 cell differentiation, while promoting iT(reg) cell differentiation" in Nature, describing the use of the Got1 knockout mouse line, made possible by receipt of frozen sperm from Got1-floxed mice from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Biological samples |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.nature.com/articles/s41586-022-05602-3.pdf |
| Title | Publication of a research article involving mice derived from frozen sperm obtained from MRC Harwell |
| Description | Publication of article "GOT1 regulates CD8(+) effector and memory T cell generation" in Cell Reports, describing the use of the Got1 knockout mouse line, made possible by receipt of frozen sperm from Got1-floxed mice from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Biological samples |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.sciencedirect.com/science/article/pii/S2211124722018915?via%3Dihub |
| Title | Publication of a research article involving mice housed at MRC Harwell |
| Description | Publication of article "Activation of the myosin motors in fast-twitch muscle of the mouse is controlled by mechano-sensing in the myosin filaments" in The Journal of Physiology, describing the use of the C57BL/6J mouse line, which was housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC. |
| URL | https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP283048?download=true |
| Title | Publication of a research article involving mice housed at MRC Harwell |
| Description | Publication of article "Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities" in Genetics in Medicine, describing the use of C57BL/6J mice, which were housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC. |
| URL | https://www.gimjournal.org/article/S1098-3600(22)00870-X/pdf |
| Title | Publication of a research article involving mice housed at MRC Harwell |
| Description | Publication of article "Gadd45g is required for timely Sry expression independently of RSPO1 activity" in Reproduction, describing the use of the several experimental mouse lines, which were housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC. |
| URL | https://rep.bioscientifica.com/downloadpdf/journals/rep/aop/rep-21-0443/rep-21-0443.pdf |
| Title | Publication of a research article involving mice housed at MRC Harwell |
| Description | Publication of article "Shift work-like patterns effect on female and male mouse behavior" in the journal "Neurobiology of sleep and circadian rhythms", describing the use of C57BL/6J mice, which were housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC. |
| URL | https://www.sciencedirect.com/science/article/pii/S2451994422000086?via%3Dihub |
| Title | Publication of a research article involving mice housed at MRC Harwell |
| Description | Publication of article "TissUExM enables quantitative ultrastructural analysis in whole vertebrate embryos by expansion microscopy", involving the use of the C57BL/6N mouse line, which was housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include the increased awareness to the research community of the ability to house experimental mice at the MLC. |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606133/pdf/main.pdf |
| Title | Publication of a research article involving mice housed at MRC Harwell |
| Description | Publication of research article "Mendelian gene identification through mouse embryo viability screening" in Genome Medicine, involving mice that were housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC, and of the technique described in the publication, carried out by MLC staff. |
| URL | https://genomemedicine.biomedcentral.com/counter/pdf/10.1186/s13073-022-01118-7.pdf |
| Title | Publication of a research article involving mice obtained from MRC Harwell |
| Description | Publication of article "Balanced gene dosage control rather than parental origin underpins genomic imprinting" in Nature Communications, describing the use of the CAST/EiJ mouse line, which was provided by the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to provide this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338321/pdf/41467_2022_Article_32144.pdf |
| Title | Publication of a research article involving oocytes provided by MRC Harwell |
| Description | Publication of article "A program of successive gene expression in mouse one-cell embryos" in Cell Reports, describing the use of the oocytes from the CAST/EiJ mouse line, which were provided by the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Biological samples |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to source oocytes of experimental mice from the MLC. |
| URL | https://www.sciencedirect.com/science/article/pii/S2211124723000347?via%3Dihub |
| Title | Publication of a research article involving phenotyping and housing of mice produced at MRC Harwell |
| Description | Publication of article "Genome-wide screening reveals the genetic basis of mammalian embryonic eye development" in BMC Biology, describing the phenotyping of IMPC mouse lines generated at MRC Harwell, which was carried out at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce these mouse strains, and increased awareness of their availability to the research community, as well as information regarding their phenotypes. |
| URL | https://bmcbiol.biomedcentral.com/counter/pdf/10.1186/s12915-022-01475-0.pdf |
| Title | Publication of a research article involving phenotyping of mice carried out at MRC Harwell |
| Description | Publication of article "Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes" in Scientific Reports, describing the phenotyping of mice carried out at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness among the research community of the ability to have phenotyping of experimental mice carried out at the MLC. |
| URL | https://www.nature.com/articles/s41598-022-19710-7.pdf |
| Title | Publication of a research article involving phenotyping of mice carried out at MRC Harwell |
| Description | Publication of article "Early embryonic lethality in complex I associated p.L104P Nubpl mutant mice" in Orphanet journal of rare diseases, which includes phenotyping of the mice at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness among the research community of the ability to have phenotyping of experimental mice carried out at the MLC. |
| URL | https://ojrd.biomedcentral.com/counter/pdf/10.1186/s13023-022-02446-y.pdf |
| Title | Publication of a research article relating to the IL19-/- mouse model |
| Description | Publication of article "IL-24 intrinsically regulates Th17 cell pathogenicity in mice" in the Journal of Experimental Medicine, describing the use of Il19-/- (C57BL/6N-Il19tm2e(EUCOMM)Hmgu/H) mice, which were sourced from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://rupress.org/jem/article-pdf/219/8/e20212443/1435623/jem_20212443.pdf |
| Title | Publication of a research article relating to the Nuf mouse model |
| Description | Publication of article "Differential parathyroid and kidney Ca(2+)-sensing receptor activation in autosomal dominant hypocalcemia 1" in EBioMedicine, describing the use of the Nuf (C3;102-CasrNuf/H; RRID:MGI:3603347) mouse line, which was provided by the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935519/pdf/main.pdf |
| Title | Publication of a research article relating to the Tmem161b null mouse model |
| Description | Publication of article "TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system" in Proceedings of the National Academy of Sciences USA, describing the use of the Tmem161b null mouse line, which was housed at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC. |
| URL | https://www.pnas.org/doi/pdf/10.1073/pnas.2209964120?download=true |
| Title | Publication of research article relating to AKr1d1-/- mouse model |
| Description | Publication of article "AKR1D1 knockout mice develop a sex dependent metabolic phenotype" in Journal of Endocrinology, describing the use of the Akr1d1 null mouse line, which was re-derived and maintained at the Mary Lyon Center at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://joe.bioscientifica.com/view/journals/joe/253/3/JOE-21-0280.xml |
| Title | Publication of research article relating to MTG8 mouse model |
| Description | Publication of article "MTG8 interacts with LHX6 to specify cortical interneuron subtype identity" in Nature Communications, describing the use of the Mtg8 conditional mutant (C57BL/6N-Runx1t1tm1a(EUCOMM)Hmgu/H) mouse line, which was generated by the IMPC at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.nature.com/articles/s41467-022-32898-6.pdf |
| Title | Publication of research article relating to investigating audible and ultrasonic noise in animal facilities |
| Description | Publication of article "Investigating audible and ultrasonic noise in modern animal facilities" in F1000Research, describing the testing of ultrasonic recording systems which was carried out at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include the increased awareness of the acoustic environment in animal facilities and the minimisation of disruption to animal welfare and perturbations in scientific research. |
| URL | https://f1000research.com/articles/11-651/v1 |
| Title | Publication of research article relating to mice housed and phenotyped at MRC Harwell |
| Description | Publication of article "Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen" in Pain, describing the use of 27 experimental mouse strains, which were housed and phenotyped at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the ability to house experimental mice at the MLC. |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100450/pdf/jop-163-1139.pdf |
| Title | Publication of research article relating to the GDF15 mouse model |
| Description | Publication of article "Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice" in Molecular Metabolism, describing the use of mice carrying the GDF15 knockout-first "tm1a allele [C57BL/6N-Gdf15tm1a(KOMP)Wtsi/H], which were sourced from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include increased awareness in the research community of the availability of this mouse line, and the ability of the researchers involved to use this to create a "conditional ready GDF15 Tm1c" allele expressing mouse. |
| URL | https://www.sciencedirect.com/science/article/pii/S2212877822001582?via%3Dihub |
| Title | Publication of research article relating to the Mxra7 mouse strain |
| Description | Publication of article "Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions" in Inflammation and Regeneration, describing the use of the Mxra7 heterozygous founder mice, which were provided by the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://inflammregen.biomedcentral.com/counter/pdf/10.1186/s41232-023-00256-8.pdf |
| Title | Publication of research article relating to the Nrxn1 alpha mouse strain |
| Description | Publication of article "Allelic contribution of Nrxn1a to autism-relevant behavioral phenotypes in mice" in PLoS Genetics, describing the use of the Nrxn1 alpha mouse line, sourced from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010659&type=printable |
| Title | Publication of research article relating to the Ramp1 mouse strain |
| Description | Publication of article "Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion" in Nature, describing the use of Ramp1fl/fl (C57BL/6N - Ramp1tm1c(EUCOMM)Wtsi/H) mice, which were sourced from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.nature.com/articles/s41586-023-05753-x.pdf |
| Title | Publication of research article relating to the Retreg3 knockout mouse model |
| Description | Publication of article "Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy" in Science Advances, describing the use of the Retreg3 KO mouse line, which was generated using the (EUCOMM/KOMP)-CSD ES cell resource at the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.science.org/doi/10.1126/sciadv.abo1215?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&r... |
| Title | Publication of research article relating to the Wars2V117L/V117L mouse model |
| Description | Publication of article "A Wars2 mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning" in Frontiers in Physiology, describing the use of the Wars2V117L/V117L mouse line, which was previously established at the Mary Lyon Centre at MRC Harwell, and was housed there during this study. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.frontiersin.org/articles/10.3389/fphys.2022.953199/full |
| Title | RNaseH2b |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Rag2_8Hum |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | RosaCreERT2/+; KRAS |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | RosaCreERT2/+; Mll3-flox/+;NRAS |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | STOCK Adcy1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| Title | STOCK Cftr |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | STOCK Igf2tm4Wrk/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | STOCK Lhx1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | STOCK Tg(Cspg4-DsRed.T1)1Akik/J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Six2 conditional |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Sod1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | T178A PKGI |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | TRN0001/0002/0005 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | TRN0011/0002/0005 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | TRN0029 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | TRN0030 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | TRN0034/0029/0030 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | TS1-TYB-DYRK1AKO-B6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Tbx1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Tbx5 K339R cKI/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Tg21/Bx |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Tg66/CBA |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Thy1-GalNAc T-CFP |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Trib1 Rosa TG (Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Mouse models |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Utytm1(Flag-Cas9-EGFP)jtu |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | VilinCre |
| Description | Facilities Research - Import |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | VillinCre |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | VillinCre |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | VillinCre |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | ZFHX3-FLOX-EM1-B6N |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Zfp189 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp248 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp263 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp263 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Mouse models |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp263 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Mouse models |
| Title | Zik1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | cAtm |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Mouse models |
| Title | cTop1(T720A) |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | hC9ORF72 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Description | Biological Sample Collection - Diamond Light Source |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Pathology team provided a weekly supply of samples including kidney, lung, skin, and brain, for concept validation and protocol development. |
| Collaborator Contribution | None |
| Impact | None as yet. |
| Start Year | 2022 |
| Description | Biological Sample Collection - STFC |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Eye samples were collected using a PluriSTEM Dispase collection technique. Samples were dissected, incubated and processed before being collected by staff at STFC for downstream experiments. |
| Collaborator Contribution | Protocol development was established by both parties. |
| Impact | Feedback on sample dissection was used to make minor adjustments to the protocol. |
| Start Year | 2022 |
| Description | Biological Sample Collection - The Pirbright Institute |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Peritoneal macrophages were collected from the abdominal cavity of multiple mice using a FCS/PBS solution. |
| Collaborator Contribution | Protocol development was managed by both parties. |
| Impact | Protocol development is still underway, collated feedback is positive so far. Adaptations to the protocol will be made if required. |
| Start Year | 2022 |
| Description | Biological Sample collection - RFI Michael Grange |
| Organisation | Rosalind Franklin Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | The Pathology department provide a monthly supply of brain tissue to the Tomography Group Leader at the Rosalind Franklin institute. These samples are used in the structural biology group as proof of concept and validation for protocol development purposes. |
| Collaborator Contribution | The researchers have provided valuable feedback on the dissection process. |
| Impact | No outcomes at present. |
| Start Year | 2022 |
| Description | Biological sample collection - RFI |
| Organisation | Rosalind Franklin Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Snap frozen liver/brain/kidney samples were supplied to a scientist at the RFI for method and instrument validation purposes. This is an ongoing project which will require sporadic supply. |
| Collaborator Contribution | None as yet. |
| Impact | No outcomes have been generated to date. |
| Start Year | 2022 |
| Description | CL - University of Sheffield |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Breeding plans and provision of animals |
| Collaborator Contribution | Discussion and funding |
| Impact | None yet |
| Start Year | 2022 |
| Description | FH- WRH Oxford |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Breeding and experimental design, phenotyping and testing of samples |
| Collaborator Contribution | Study design |
| Impact | Non yet |
| Start Year | 2022 |
| Description | FPWR - PCAN |
| Organisation | Foundation for Prader-Willi Research (FPWR) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Production and phenotyping of new and existing mouse models |
| Collaborator Contribution | Provided data from patients and collaborated in planning animal studies |
| Impact | Phenotyping and expression data |
| Start Year | 2019 |
| Description | NATA- delivery of nucleic acids |
| Organisation | Medical Research Council (MRC) |
| Department | Nucleic Acids Therapeutics Accelerator (NATA) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Delivery of nucleic acids to mice |
| Collaborator Contribution | formulation of nucleic acids |
| Impact | data |
| Start Year | 2022 |
| Description | Notch 1 variants |
| Organisation | University of Dundee |
| Department | College of Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Productions and management of mouse research |
| Collaborator Contribution | ideas from other model organisms |
| Impact | mouse strains data publications |
| Start Year | 2021 |
| Description | RC - Bristol |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experimental design and production of transgenic mice. breeding complex transgenics of mice |
| Collaborator Contribution | expertise |
| Impact | New mouse models generated export mice |
| Start Year | 2016 |
| Description | Supply to UK-HSA |
| Organisation | UK Health Security Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Organisation of breeding schemes and supply of mice |
| Collaborator Contribution | On-going study on mice supplied |
| Impact | Non yet |
| Start Year | 2022 |
| Description | TG - Edinburgh |
| Organisation | University of Edinburgh |
| Department | Edinburgh Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Phenotyping and data |
| Collaborator Contribution | Clinical data and experimental design |
| Impact | None yet |
| Start Year | 2022 |
| Description | VS - QMUL |
| Organisation | Queen Mary University of London |
| Department | Queen Mary Innovation |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Breeding, experimental design, phenotyping and analysis. Advice on appropriate phenotyping pipeline. |
| Collaborator Contribution | Discussion, clinical information, experimental design. |
| Impact | None yet |
| Start Year | 2022 |
| Description | 7th UK-China Seminar discussion session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 7th UK-China Seminar discussion session- talk to Chinese animal researchers |
| Year(s) Of Engagement Activity | 2022 |
| Description | Advanced Mouse Genetics Courses held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 16 delegates attended the Advanced Mouse Genetics course. This course explores more complex genetic topics, including multiple allele crosses, complex disease models and will inform breeding strategies and experimental design rather than give a complete guide to the molecular biology. Our team of experienced trainers will support you to examine how different modifications lead to different breeding strategies, the importance of genetic consistency and integrity, different modes of inheritance and troubleshooting issues of reproducibility. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Aureus school career event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | school career fair participation |
| Year(s) Of Engagement Activity | 2023 |
| Description | Breeding strategies- 3Rs |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | online 3Rs event of the Universities of St Andrews, Dundee and Aberdeen: main topic: breeding strategies |
| Year(s) Of Engagement Activity | 2022 |
| Description | Changing UK workforce- challenges with skills and knowledge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Changing UK workforce- challenges with skills and knowledge |
| Year(s) Of Engagement Activity | 2022 |
| Description | Changing working practices |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk and debate on changing working practices in animal research in the UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Conditional Transgenics Course held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 9 delegates attended the Conditional Transgenics course. This course is designed to introduce the principles behind conditional genetic modifications, experimental design and analysis. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Ethics of using laboratory animals in research talk at ISDB - Algarve - Prtugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | talk on the subject |
| Year(s) Of Engagement Activity | 2022 |
| Description | FELASA - Student presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk about research reproducibility for animal technicians at FELASA |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genome editing and model validation at IMGC conference - Vancouver |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | poster on the subject |
| Year(s) Of Engagement Activity | 2022 |
| Description | Germ Free Workshop held at Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 8 delegates attended the Advance Training Centre for a workshop entitled: Establishing and Maintaining a Mouse Germ-Free Facility. This course is designed to provide a comprehensive introduction into how germ-free facilities can be run on a day-to-day basis and will be led by experts in gnotobiology (both academic and industry partners) using a 'hands-on' approach to establishing and maintaining a germ-free facility. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Harwell campus maangement meeting with Japanese industry delegation. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Approximately 30 people from more than 15 Japanese scale up companies in life-sciences and AI visited the Harwell Campus to gain an insight into how the campus operated and to explore the opportunities for collaboration with the industry/academic partners based at the Harwell Campus |
| Year(s) Of Engagement Activity | 2023 |
| Description | Harwell campus meeting with Japanese embassy delegation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | A delegation from the Japanese embassy visited the Harwell Campus to gain an insight into how industry/academic partners on site collaborated with each other and across the UK's private and industrial sectors |
| Year(s) Of Engagement Activity | 2023 |
| Description | Infrafrontier AWEX (animal welfare expert group) meeeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | This meeting was set up by the Infrafrontier animal welfare expert group to promote and champion best practice in the use and dissemination of mouse models of human disease/gene function across the European consortium |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.infrafrontier.eu |
| Description | Infrafrontier EMMA - quality management meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This meeting was set up by the Infrafrontier expert group to review best practice in cryopreservation and dissemination of mouse models of human disease/gene function across the European consortium |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.infrafrontier.eu |
| Description | Infrafrontier general meeting -Oulu, Finland |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This meeting was held to present specific updates on Infrafrontier's recent activities and to discuss the future direction and scope of the Infrafrontier project |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.infrafrontier.eu |
| Description | Introduction to Editing the Mouse Genome course held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 4 delegates attended the Introduction to Editing the Mouse Genome course. This course is designed to introduce the principles of design of genome editing, efficient strategies for screening of founder animals and comprehensive validation of newly established lines. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.har.mrc.ac.uk/training/course-portfolio/ |
| Description | Introduction to Genetically Altered Mice Course held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 11 delegates attended the Introduction to Genetically Altered Mice course. This course introduces animal technicians and researchers to the background of mouse genetics and will cover topics such as Mendelian gene inheritance and genetic crosses, as well as aspects of more complex genetics intended to inform breeding strategies in establishing new genetically altered lines. |
| Year(s) Of Engagement Activity | 2022 |
| Description | King Alfred's School career event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | partecipation at school career event |
| Year(s) Of Engagement Activity | 2023 |
| Description | LASA- National Mouse Genetics Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | LASA presentation introducing the Mouse Genetics Network |
| Year(s) Of Engagement Activity | 2022 |
| Description | Launch of the new Mary Lyon Centre website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | the new Mary Lyon Centre website was launched as the MRC Harwell Insitute ceased to exist and its website was archived. The new site, apart from the usual service provision, has a whole section dedicated to training where the new Advance training centre takes centre stage and allows people from various level of experience and education to join our expert led training courses. The site also encourages campus entities to use our facilities for their own training , networking and other events. Work experience programmes are also advertised using this channel |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://har.mrc.ac.uk |
| Description | Luxembourg 3R's symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Spoke at the 3R's symposium about best practice in research using GA mice. Discussion with researchers, as well as politicians and students. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Microinjection and Electroporation Course held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 8 delegates attended the Microinjection and Electroporation course. The Microinjection and Electroporation course provides tailored and hands-on training in embryo harvesting, set up and operation of microinjection rigs, pronuclear and cytoplasmic microinjection and the process of electroporation to introduce CRISPR-Cas9 reagents to embryos. In addition, this course offers a demonstration of surgical embryo transfer and the opportunity to meet and discuss your specific requirements with experts in IVF technology, CRISPR-Cas9 design and mouse colony management. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.har.mrc.ac.uk/training/course-portfolio/ |
| Description | Mouse Embryo and Sperm Cryopreservation Course held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 11 delegates attended the Mouse Embryo and Sperm Cryopreservation course. Cryopreservation allows long-term storage of embryos and sperm, providing a convenient way to preserve, protect and transport mouse strains used in biomedical research. Archiving scientifically relevant mouse lines also adheres to good animal welfare practices by removing the need for continued animal breeding and is integral to any comprehensive colony management programme. Running bi-annually since 2004, this course provides practical experience in murine embryo and spermatozoa freezing techniques routinely used at MRC Harwell and a simple, robust in vitro fertilisation procedure. The course will also cover the basic laboratory skills required when working in an assisted reproductive biology environment such as pipetting, weighing, microscope use and embryo handling. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.har.mrc.ac.uk/training/course-portfolio/ |
| Description | Mouse Genetics cours at FELASA conference - Marseille |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | mouse genetics course |
| Year(s) Of Engagement Activity | 2022 |
| Description | Mouse phenotyping- Institute de pasteur |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on phenotyping to masters students and supervisors |
| Year(s) Of Engagement Activity | 2022 |
| Description | Practical Laboratory Skills courses held at the Advance Training Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 51 delegates attended the Practical Laboratory Skills courses. This course will cover basic theoretical and practical laboratory skills including preparing COSHH risk assessments, good laboratory practice, use of fume hoods/biosafety cabinets, centrifuges and other laboratory equipment, pipetting skills, using balances and preparing reagents and solutions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.har.mrc.ac.uk/training/course-portfolio/ |
| Description | RAL career fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Rutherford and Appleton Laboratories career fair participation |
| Year(s) Of Engagement Activity | 2023 |
| Description | Revealing the full picture- scandinavia 3Rs |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Revealing the full picture: How continuous and comprehensive phenotyping enhance phenotyping and welfare assessment |
| Year(s) Of Engagement Activity | 2022 |
| Description | Sex- inclusion in experimental design |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-presented data to support the inclusion of both sexes in life science experiments |
| Year(s) Of Engagement Activity | 2022 |
| Description | Validation of Genetic alterations workshop at ISTT - Helsinki |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | workshop on the subject |
| Year(s) Of Engagement Activity | 2022 |
| Description | general visits by 16 people for outreach activities |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | these were visits organised as outlreach for people with a general interest in what we do |
| Year(s) Of Engagement Activity | 2022 |
| Description | rebranding of the MRC Harwell LinkedIn account to Mary Lyon Centre |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | refocused the channel to attract wider audience |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.linkedin.com/company/3356237 |
| Description | rebranding of the MRC Harwell Twitter account to Mary Lyon Centre |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | the account has been relaunched with a new focus on MLC activities and engaging with a wider audience |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/MRCHarwell |
| Description | visits and tours of our facility |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Science related visits and tours of our facility by external current and prospective collaborators and colleagues from other scientific establishements who felt it beneficial to observe our spaces and activities and discuss our practices and methods |
| Year(s) Of Engagement Activity | 2022 |
| Description | visits by 77 people for training and sharing of practices used at the MLC |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | visits and tours organised for people wanting to observe our practices and methods and getting training in some of our protocols |
| Year(s) Of Engagement Activity | 2022 |