Entero-endocrinology including the effects of bariatric surgery

Lead Research Organisation: University of Cambridge

Abstract

The gut releases signals that coordinate how it handles food, how nutrients are distributed in the body and how much food is consumed. Modifying these signals presents an opportunity to treat obesity and high blood sugar and it is thought that changes in these signals are important in the positive effects of bariatric surgery. We use mice that have been genetically altered to either label the cells that produce these signals or the cells that receive the signals, enabling us to identify and characterise changes when these mice undergo bariatric surgery. We hope that understanding these changes will, in the long term, enable us to modify gut-derived signals to treat metabolic diseases in humans without the need of surgical intervention.

Technical Summary

The enteroendocrine system is a key player in the control of postprandial nutrient homeostasis, modulating the transit and digestion of nutrients within the intestine, the disposal of nutrients in peripheral organs and affecting future feeding behaviour/appetite. Some peptide hormones, notably glucagon-like peptide-1, are already exploited to treat diabetes and obesity, whilst changes in enteroendcrine responses are thought to contribute to the beneficial metabolic outcomes of bariatric surgery. This programme uses genetically modified mouse models to address the mechanisms underlying enteroendocrine changes in response to bariatric surgery with the aim to modulate the enteroendocrine system for the treatment of metabolic disease. We compare in vivo results in mice after vertical sleeve gastrectomy with observations in human volunteers, which have undergone gastrectomy with Roux-en-Y type reconstruction of the upper small intestine and in vitro studies with primary mixed epithelial cultures and intestinal organoids of both human and murine origin. Transcriptomic, mass-spec-based peptidomic, optical single cell second messenger dynamic and electrophysiological investigations are combined with pharmacological and/or genetic manipulations to identify and characterise signalling mechanisms underlying enteroendocrine hormone release and action.

Publications

10 25 50

publication icon
Arora T (2018) Microbial regulation of the L cell transcriptome. in Scientific reports

 
Description EASD travel grant
Amount € 300 (EUR)
Organisation European Association for the Study of Diabetes (EASD) 
Sector Charity/Non Profit
Country Germany
Start 10/2018 
End 10/2018
 
Description Jo Lewis, BSN symposium support for Physiology 2019, Aberdeen, UK
Amount £2,000 (GBP)
Organisation British Society for Neuroendocrinology 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2019
 
Description Jo Lewis, BSN symposium support for the ECR day at the BSN's annual conference, Glasgow, UK
Amount £5,000 (GBP)
Organisation British Society for Neuroendocrinology 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 01/2019
 
Description Jo Lewis, The Physiological Society satellite support for Physiology 2019, Aberdeen, UK
Amount £20,000 (GBP)
Organisation Physiological Society 
Sector Charity/Non Profit
Country Global
Start 08/2019 
End 08/2019
 
Description Jo Lewis, The Physiological Society symposium support for Experimental Biology, Orlando,
Amount £2,000 (GBP)
Organisation Physiological Society 
Sector Charity/Non Profit
Country Global
Start 06/2019 
End 06/2019
 
Description Wellcome PhD studentship to Elisabeth O'Flaherty
Amount £180,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description Wellcome PhD studentship to Emily Miedzybrodzka
Amount £180,824 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 09/2021
 
Title Gipr-Cre transgenic mouse 
Description GIPR-Cre mouse enabling identification and manipulation of cells expressing Gipr 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2016 
Provided To Others? Yes  
Impact Collaborations and publications. Research collaboration with Eli Lilly, investigating MOA of GLP1/GIP dual agonists (currently in phase 3 clinical trials) 
 
Title Glu-CreERT2 
Description Tamoxifen-inducible cre expression driven by the proglucagon promoter 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2017 
Provided To Others? Yes  
Impact Shared with academic collaborators and licensed to industry 
 
Title Guanylin-Venus transgenic mouse 
Description Guanylin-venus mouse, enabling identification and characterisation of cells expressing guanylin 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2019 
Provided To Others? Yes  
Impact Publication 
 
Title Insl5-rtTA mouse 
Description transgenic mouse Insl5-rtTA allowing identification and manipulation of INSL5-expressing cells 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? Yes  
Impact publications 
 
Title Rxfp4-Cre transgenic mouse 
Description Rxfp4-Cre transgenic mouse 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? No  
Impact BBSRC-iCASE studentship joint with AstraZeneca to investigate central signalling involving Rxfp4 
 
Description Acosta 
Organisation Mayo Clinic
Country United States 
Sector Charity/Non Profit 
PI Contribution Training provided to Acosta's group
Collaborator Contribution Analysis of patient samples
Impact None
Start Year 2018
 
Description Brubaker lab 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Mouse models and discussion
Collaborator Contribution Experimentation and project design
Impact Publication
Start Year 2015
 
Description G/R Bertie Goettgens, Single Cell RNAseq 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Experiments
Collaborator Contribution Experiments
Impact none yet
Start Year 2015
 
Description GIP receptor localisation and function 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution We generated a gipr knockin mouse, which has been shipped to Toronto
Collaborator Contribution Analysis of the genetically modified mouse in Toronto
Impact None to date
Start Year 2016
 
Description Gastrectomy clinicians 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples
Collaborator Contribution Identification of suitable patients
Impact Publications
Start Year 2015
 
Description Generation of organoids from transgenic models 
Organisation Royal Netherlands Academy of Arts and Sciences
Department Hubrecht Institute
Country Netherlands 
Sector Academic/University 
PI Contribution We provided tissue from transgenic mouse models
Collaborator Contribution Collaborators will generate organoids for use in their research programme
Impact None to date
Start Year 2016
 
Description Heisler. CNS appetite circuitry 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Transgenic mouse models
Collaborator Contribution Data analysis
Impact Publication
Start Year 2019
 
Description Holst perfused pancreas 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Ideas for experiments
Collaborator Contribution Perfused pancreas to test ideas developed in Cambridge
Impact Publication
Start Year 2015
 
Description LGC peptidomics 
Organisation LGC Ltd
Country Global 
Sector Private 
PI Contribution Supporting a BBSRC iCASE studentship
Collaborator Contribution Analysis and training
Impact One publication to date
Start Year 2017
 
Description Larraufie Paris lab 
Organisation French National Institute of Agricultural Research
Country France 
Sector Academic/University 
PI Contribution Experimentation
Collaborator Contribution Experimentation and project planning
Impact Publications
Start Year 2016
 
Description Lilly GIPR 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution Research in the field of central GIPR signalling
Collaborator Contribution Tool compounds and unpublished data
Impact None yet
Start Year 2018
 
Description Medimmune BBSRC iCASE (Galvin) 
Organisation MedImmune
Department MedImmune Cambridge
Country United Kingdom 
Sector Private 
PI Contribution Supervision of PhD student
Collaborator Contribution Joint supervision of student, training, peptide synthesis
Impact None yet
Start Year 2016
 
Description Mercodia assay validation 
Organisation Mercodia AB
Country Sweden 
Sector Private 
PI Contribution Mass spec analysis to validate Mercodia's glucagon assay. Measurement of patient samples using glucagon and glicentin assays to establish the cause of assay cross reactivity
Collaborator Contribution Provision of assays and suggestions for protocol changes to remove cross-reactivity
Impact Mercodia published a white paper outlining the collaboration and how it has impacted on the use of the glucagon assay
Start Year 2018
 
Description Moffett. Trophoblast physiology 
Organisation University of Cambridge
Department Department of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution Application of LC-MS/MS peptidomics to analysis of trophoblast organoids
Collaborator Contribution Development of trophoblast organoids
Impact Publication
Start Year 2018
 
Description Rinaman, Fadool, Williams. Central GLP-1 signalling 
Organisation Florida State University
Country United States 
Sector Academic/University 
PI Contribution Provision of transgenic mouse models
Collaborator Contribution Dissection of CNS appetite circuitry
Impact multiple publications
Start Year 2013
 
Description Ulster, transgenic mice 
Organisation Ulster University
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster
Collaborator Contribution Collaborators will work with the transgenic model
Impact None to date
Start Year 2016
 
Description Valverde. PTP1B in GLP-1 secretion 
Organisation Autonomous University of Madrid
Country Spain 
Sector Academic/University 
PI Contribution Hosted visiting student and provided training
Collaborator Contribution Visiting student brought project
Impact Publication
Start Year 2017
 
Description Yuki Oka 
Organisation California Institute of Technology
Department Division of Biology and Biological Engineering (BBE)
Country United States 
Sector Academic/University 
PI Contribution Provision of mouse models
Collaborator Contribution Research contribution
Impact Nature publication
Start Year 2017
 
Title GIP-Cre 
Description GIP-Cre genetically modified mouse model 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact MTAs in place for sharing with academic collaborators
 
Title GLP1R Ab 
Description Joint development of anti-GLP1R antibody together with MedImmune 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed Yes
Impact Sharing with academic groups
 
Description 13th annual Biomarkers Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact An industrial congress bringing together a variety of industrial technologies for the measurement of biomarkers
Year(s) Of Engagement Activity 2018
 
Description AEA. Oral presentation at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands.
Year(s) Of Engagement Activity 2019
 
Description AEA. Oral presentation at BSN Neuroendocrinology Celebrate Symposium for ECRs; Glasgow, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk at BSN Neuroendocrinology Celebrate Symposium for Early Career Researchers; Glasgow, UK
Year(s) Of Engagement Activity 2019
 
Description AEA. Oral presentation at Experimental Biology conference; Orlando, US. 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker at Experimental Biology conference; Orlando, US. Networking
Year(s) Of Engagement Activity 2019
 
Description AEA. Oral presentation to Eli Lilly; Indianapolis, US, 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Research presentation to Eli Lilly.
Year(s) Of Engagement Activity 2019
 
Description AEA. Poster at EASD Incretin Study Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact AEA Poster at Incretin Study Group "The role of glucose-dependent insulinotropic polypeptide receptor-expressing neurons in the hypothalamus"
Year(s) Of Engagement Activity 2019
 
Description AEA. Poster at NovoNordisk Foundation Metabolism in Action conference; Copenhagen, Denmark 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation at Novonordisk Foundation Metabolism in Action conference; Copenhagen, Denmark. Sparked debate.
Year(s) Of Engagement Activity 2019
 
Description Big Biology Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Big Biology Day - engagement activities explaining metabolic research to families
Year(s) Of Engagement Activity 2017
 
Description CAS. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact CAS. Poster at EASD incretin study group: "Tracking the development and release of hormone-containing vesicles in murine L-cells"
Year(s) Of Engagement Activity 2019
 
Description Cambridge Science Festival - family activities 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Drop-in hands-on event for families and children. Sparked questions from children and parents
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Cambridge Science festival, family weekends 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact promoted interest in science taking place at the inst
Year(s) Of Engagement Activity 2013,2014,2015
 
Description Cambridgeshire Girlguiding Girls in STEM event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Cambridgeshire Girlguiding Girls in STEM event
Year(s) Of Engagement Activity 2020
 
Description DG Poster at EASD study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DG. Poster at Incretin Study Group: "Modelling human enteroendocrine cells using adult intestinal organoids"
Year(s) Of Engagement Activity 2019
 
Description DG. Poster at Copenhagen Biosciences Conference on Intestinal Organoids 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Modelling hormone secretion in human enteroendocrine cells using adult intestinal organoids"
Year(s) Of Engagement Activity 2019
 
Description EB. Poster at Academic Foundation Programme and NIHR BRC and BTRU Trainee's Annual Research Day 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact "Localisation and characterisation of glucose-dependent insulinotropic polypeptide receptor (GIPR) expressing cells"
Year(s) Of Engagement Activity 2018
 
Description EM. Poster at Copenhagen Bioscience Conference on Intestinal Organoids 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EM Poster. "Using human duodenal organoids to study motilin production and secretion"
Year(s) Of Engagement Activity 2019
 
Description EM. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EM. Poster at EASD incretin study group. "The contribution of TRP channels to L-cell signalling"
Year(s) Of Engagement Activity 2019
 
Description FR SSIB annual meeting 2019 - poster presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SSIB annual meeting 09-13Jul2019 (poster): "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis"
Year(s) Of Engagement Activity 2019
 
Description FR oral presentation at EASD annual meeting 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact oral presentation "GLP-1 secreting enteroendocrine cells co-release ATP to modulate vagal afferent neuronal activity" delivered on 05Oct2018
Year(s) Of Engagement Activity 2018
 
Description FR oral presentation at Wellcome Trust meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Wellcome Meeting at Sanger 31Jan-01Feb2019 (oral): "A role of hypothalamic glucose-dependent insulinotropic polypeptide receptor (GIPR) in feeding behaviour"
Year(s) Of Engagement Activity 2019
 
Description FR. Poster at EASD incretin study group. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FR poster at EASD study group: "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis"
Year(s) Of Engagement Activity 2019
 
Description FR. presentation at Danish Diabetes Academy Winter School for postdoctoral researchers, at Higuerõn Hotel in Malaga/Spain 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Incretins along the gut-pancreas-brain axis".
Year(s) Of Engagement Activity 2019
 
Description FR: Mercodia Diagnostics, Uppsala. Invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Invited to talk to Mercodia about how our mass spec analysis methods complement their immunoassay development
Year(s) Of Engagement Activity 2019
 
Description GPR. Cambridge UGI cancer symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact "The post-gastrectomy patient, metabolic considerations"
Year(s) Of Engagement Activity 2018
 
Description JL. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact JL. Poster at EASD study group. "RXFP4, the cognate receptor for insulin-like peptide 5, alters food preference in mice"
Year(s) Of Engagement Activity 2019
 
Description MRL Science Slam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The presenters (a post doc and student together) won a prize for their presentation
Year(s) Of Engagement Activity 2018
 
Description MY Poster at Incretin Study Group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact MY poster at Incretin Study Group: "Amino acid sensing in K and L cells from mouse duodenal organoids"
Year(s) Of Engagement Activity 2019
 
Description MY. Oral presentation at Diabetes UK Annual Professional Conference 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Metformin alters glucose uptake and metabolism in intestinal cells
Year(s) Of Engagement Activity 2019
 
Description OW. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact OW poster at EASD incretin study group: "Distribution of G protein coupled relaxin/insulin-like family peptide receptor-4 (RXFP4) expressing cells in the mouse brain"
Year(s) Of Engagement Activity 2019
 
Description PL. Talk at Incretin Study Group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact PL. Talk at Incretin Study Group. "Peptidomics to study enteroendocrine cells after bariatric surgery"
Year(s) Of Engagement Activity 2019
 
Description REF Poster at SymBLS 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients
Year(s) Of Engagement Activity 2019
 
Description REF. Poster at DMDG open meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact "Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients"
Year(s) Of Engagement Activity 2019
 
Description REF. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact REF poster at EASD study group "A multiplex method for quantifying gut hormone peptides using Mass Spectrometry"
Year(s) Of Engagement Activity 2019
 
Description REF. Poster at REID Bioanalytical Forum 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Immunoassay vs Mass Spectrometry -Measuring insulin and insulin analogues in human plasma
Year(s) Of Engagement Activity 2019
 
Description RGK. American Society for Mass Spectrometry (ASMS) 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Waters user group meeting, presentation:
"LC-MS analysis of plasma from patients with insulin autoimmune syndrome"
Waters MS focused user meeting (Pharmaceutical track)
Outcome: Video of talk available on Waters website, video interview on Select Science website, as well as an in-lab video interview.
Year(s) Of Engagement Activity 2019
 
Description RGK. Poster at EASD incretin study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster at EASD incretin study group: "Proglucagon peptide analysis - will the real peptide please stand up!"
Year(s) Of Engagement Activity 2019
 
Description RGK. Reid Bioanalytical Forum 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact "LC-MS analysis of plasma from patients with insulin autoimmune syndrome"
Meeting focussing on broad bioanalytical approaches for wide range of analytes
Outcome: Video interview by Bionalaysis zone, available on their website
Year(s) Of Engagement Activity 2019
 
Description RGK. Waters UK and Ireland Clinical User Meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Waters UK and Ireland Clinical User Meeting 2019
"LCMS Analysis of Proinsulin Derived Peptides"
Waters meeting for users of MS systems in clinical environments
Year(s) Of Engagement Activity 2019
 
Description SG. Poster at EASD incretin study group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SG. Poster at EASD study group. "Characterisation of novel gut-derived peptides in vivo and in vitro"
Year(s) Of Engagement Activity 2019
 
Description Suffolk Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Suffolk Science Festival
Year(s) Of Engagement Activity 2020
 
Description TD. Poster at EASD study group 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TD. Poster at EASD incretin study group. "Neutral amino acid transporter: SLC6a19- linking amino acid sensing to gut hormone secretion?"
Year(s) Of Engagement Activity 2019
 
Description VBL talk at Incretin 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact VBL talk at EASD Incretin Study group, "Adenosine triphosphate (ATP) is released from glucagon-like peptide 1 (GLP-1) secreting cells and signals to vagal afferent neurons"
Year(s) Of Engagement Activity 2019
 
Description VBL. Poster at Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact VBL presented a poster at a local Cambridge Neuroscience Association meeting at Robinson College on March 14th, 2019. It was called "Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience" and the poster title was "ATP is released from GLP-1 secreting enteroendocrine cells and signals to vagal afferent neruones". It was a valuable experience sharing our work on gut-brain signalling to the larger Cambridge neuroscience community.
Year(s) Of Engagement Activity 2019