Epigenetic programming of metabolic health across the life-course
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
We aim to understand why babies who are exposed to a poor diet in the womb are more likely to develop type 2 diabetes or become obese as adults. Obesity and associated conditions like type 2 diabetes are major health problems in the UK and western countries, influencing both quality and quantity of life. Approximately one third of the adult population in the UK are obese and over 4 million people in the UK are affected by diabetes. We know that how well a baby is nourished in the womb is one factor that influences how likely they are to develop type 2 diabetes and obesity as adults. Therefore, it is very important to understand how early diet has such effects as this may help us develop new medicines for these common conditions. We know that one way in which a poor diet during early life impacts on health is through “epigenetic” processes. This is the way the environment controls which parts of DNA are used to make proteins and therefore how well a cell works. Recent advances in genome research allow us to look at the epigenetic regulation of all the genes in our DNA (~22,000). In this project we will use these technological advances to identify faulty genes that cause metabolic diseases because of poor early diet.
Technical Summary
We aim to define the epigenetic mechanisms mediating the relationship between suboptimal nutrition in utero and metabolic disease in later life. It is well established that altered patterns of early growth, as a consequence of both in utero under-nutrition and over-nutrition are associated with increased risk of metabolic diseases such as type 2 diabetes and obesity in later life. These conditions are major health care issues of the 21stcentury in both the developed and developing world. Therefore, understanding mechanisms by which these conditions arise and which could therefore be targeted within intervention and prevention strategies could have a major impact. Although there is strong evidence, from human and animal studies that early diet, plays an important role in mediating these relationships, the precise molecular mechanisms by which diet during critical periods of development programmes metabolism and consequently influences long-term health remain poorly defined. Permanent changes in epigenetic regulation of gene expression have emerged as an important contributing mechanism. Our previous studies demonstrated that promotor-enhancer interactions and small non-coding RNAs such as miRNAs represent key nodes of epigenetic regulation leading to modulation of expression of complex gene networks. In the current proposal, using adipose tissue from well-established mouse models of developmental programming in combination with human biopsy material, we will apply state of the art epigenetic technology including promoter-capture Hi-C with complex bioinformatic analysis, to identify changes in 4D chromatin structure that mediate programming effects. Furthermore, we will establish if non-coding RNAs represent particular “hot spots” within the genome for such regulation. We will define the function of these non-coding RNAs and promotor-enhancer interactions in vitro using a combination of primary cell cultures and adipocyte cell lines and applying CRISPR-Cas9 genome editing technology. Our studies will therefore define novel programming mechanisms that are conserved between rodents and humans. Any programmed epigenetic changes that we identify could, in the future, be used prognostically, diagnostically and therapeutically to target individuals at risk of metabolic disease resulting from suboptimal early life programming. The findings could therefore help combat the growing burden of complex diseases such as type 2 diabetes.
Publications
Ahmad A
(2024)
Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.
in Communications medicine
Aiken C
(2021)
An Update to the Article "Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis".
in Diabetes therapy : research, treatment and education of diabetes and related disorders
Aiken CE
(2019)
Early life environment influences the trajectory of post-partum weight loss in adult female rats.
in Reproductive biomedicine online
Aiken CE
(2019)
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Aiken CE
(2019)
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
in The Journal of physiology
Aiken CE
(2019)
Assaying Reproductive Capacity in Female Rodents.
in Methods in molecular biology (Clifton, N.J.)
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00014/1 | 31/03/2018 | 31/03/2024 | £2,995,583 | ||
| MC_UU_00014/2 | Transfer | MC_UU_00014/1 | 31/03/2018 | 31/03/2024 | £2,871,979 |
| MC_UU_00014/3 | Transfer | MC_UU_00014/2 | 31/03/2018 | 31/03/2024 | £1,667,444 |
| MC_UU_00014/4 | Transfer | MC_UU_00014/3 | 31/03/2018 | 31/03/2024 | £1,743,788 |
| MC_UU_00014/5 | Transfer | MC_UU_00014/4 | 31/03/2018 | 31/03/2024 | £3,355,490 |
| MC_UU_00014/6 | Transfer | MC_UU_00014/5 | 31/03/2018 | 31/03/2024 | £1,325,715 |
| Title | Efficacy and side-effect profile of different formulations of metformin: a systematic review and meta-analysis. |
| Description | Article full text The above summary slide represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see "read the peer-reviewed publication" opposite). © The authors, CC-BY-NC 2021. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://adisjournals.figshare.com/articles/media/Efficacy_and_side-effect_profile_of_different_formu... |
| Title | Efficacy and side-effect profile of different formulations of metformin: a systematic review and meta-analysis. |
| Description | Article full text The above summary slide represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see "read the peer-reviewed publication" opposite). © The authors, CC-BY-NC 2021. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://adisjournals.figshare.com/articles/media/Efficacy_and_side-effect_profile_of_different_formu... |
| Description | IMS-MRL Director's Collaborative award for MRL postoctoral researchers to Ionel Sandovici |
| Amount | £2,720 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2023 |
| Description | KAUST |
| Amount | £96,540 (GBP) |
| Funding ID | G101461 |
| Organisation | King Abdullah University of Science and Technology (KAUST) |
| Sector | Academic/University |
| Country | Saudi Arabia |
| Start | 09/2020 |
| End | 11/2023 |
| Title | Mir-483 overexpressing mouse model |
| Description | Inducible TET-OFF mouse model of expression of miR-483, that can be spatially and temporally regulated |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | Manuscript in preparation |
| Title | Promoter-capture HiC in mouse. 3T3 cell line |
| Description | We performed a genome-wide screen, in 3T3L cells by PC-HiC, aimed at identifying the transcriptional 'interactome' across different time-points during differentiation of pre-adipocytes to adipocytes. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | Identification of putative novel regulators of adipogenesis |
| Title | mir-483 knock-out |
| Description | Mice that lack miR-483 in all cell types, achieved by homologous recombination in ES cells and germ line transmission of the mutation |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | Manuscript in preparation |
| Title | Proteomics in early embryos of over expressing miR-483 mice |
| Description | Tandem mass tag (TMT) proteomics studies in embryos that over express miR-483 and wild-type controls |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | manuscript in preparation |
| Title | RNA Seq data in neonatal mouse pancreas |
| Description | RNA Seq was performed in neonatal mouse pancreas between mesenchyme cells and non-mesenchyme cells in wild-type mice and in mice that lack IGF2 from the developing pancreatic mesenchyme. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | N/A - work just published |
| Title | Transcriptome in early embryos over expressing miR-483 |
| Description | RNA Seq performed in early embryos of mice over expressing miR-483 from the endogenous locus (i.e. 5 copies of miR-483) and wild-type controls |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Manuscript in preparation |
| Title | Transcriptome of miR-483 knock-out fetal liver |
| Description | RNA Seq of mouse fetal liver derived from miR-483 knock-out mice and wild-type controls. |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Manuscript in preparation |
| Description | Bioinformatic Analysis of PC-HiC data - Bori Mifsud PI |
| Organisation | Hamad bin Khalifa University |
| Country | Qatar |
| Sector | Academic/University |
| PI Contribution | We have performed a genome-wide screen of promoter interactions, using PC-HiC, in a well established in vitro model of adipogenesis (mouse 3T3L1 cells) |
| Collaborator Contribution | Bioinformatic analysis of the genome-wide PC-HiC screen using 'Gothic' as pipeline |
| Impact | Presentation at the 2019 IMB Conference - Chromosome Territories & Nuclear Architecture, held from 30 October to 01 November 2019, at the Institute of Molecular Biology (IMB), Mainz, Germany. |
| Start Year | 2018 |
| Description | Epigenome studies Human Obesity |
| Organisation | University of Porto |
| Department | Abel Salazar Institute of Biomedical Sciences |
| Country | Portugal |
| Sector | Public |
| PI Contribution | Expertise in Epigenetics; host lab of visiting scientists |
| Collaborator Contribution | Collection of adipose tissue from obese people and lean controls |
| Impact | n/a |
| Start Year | 2018 |
| Description | Identification of regulators of adipogenesis by in vitro genome-wide siRNA screen in mouse stromal cells |
| Organisation | University of Cambridge |
| Department | Institute of Metabolic Science (IMS) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We performed a genome-wide screen, in 3T3L cells by PC-HiC, aimed at identifying the transcriptional 'interactome' across different time-points during differentiation of pre-adipocytes to adipocytes. |
| Collaborator Contribution | Our partners (led by Prof. Steve O'Rahilly at IMS, including collaborators at the MRC Cancer Unit) performed a genome-wide siRNA screen in mouse stromal cells (OP9) during differentiation to adipocytes. We have now cross-referenced the 2 screens, i.e. PC-HiC and g-wsiRNA) and identified a number of genes/regulatory elements that may play novel roles in adipogenesis. This list of genes is currently undergoing functional testing in Drosophila (see other collaborations). |
| Impact | N/A |
| Start Year | 2019 |
| Description | In vivo Drosophila siRNA to validate functionally new conserved adipogenic genes |
| Organisation | Hamad bin Khalifa University |
| Country | Qatar |
| Sector | Academic/University |
| PI Contribution | We performed a genome-wide screen in mouse 3T3L cells by PC-HiC, which was aimed at identifying the transcriptional 'interactome' across different time-points during differentiation of pre-adipocytes to adipocytes. This screen has led to the identification of a number of putative new genes involved in adipogenesis, which were confirmed in vitro by siRNA in another mouse line, and will now be tested in vivo (in Drosophila) by our collaborators in Doha, Qatar. |
| Collaborator Contribution | Dr. Mohammad Farhan is currently testing, by in vivo siRNA in Drosophila, the new genes that were identified by us using PC-HiC in 3T3L cells. The list of genes provided to Dr. Farhan was further narrowed down by the work of collaborators within the Clinical School in Cambridge, using a siRNA genome-wide screen for adipogenesis in a mouse line. |
| Impact | N/A |
| Start Year | 2020 |
| Description | MicroRNA programming and metabolism |
| Organisation | University of Cambridge |
| Department | Institute of Metabolic Science (IMS) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We led the research about the role of Igf2 and miR-483 in pancreas development and function, and the role of microRNAs in programming of fatty liver disease |
| Collaborator Contribution | Toni Vidal-Puig's lab contributed expertise in insulin tolerance tests and human liver tissue |
| Impact | 1 paper published (PLoS Genetics) and 1 just accepted for publication (Scientific Reports) Published paper: Constanze M. Hammerle , Ionel Sandovici , Gemma V. Brierley, Nicola M. Smith, Warren E. Zimmer, Ilona Zvetkova, Haydn M. Prosser, Yoichi Sekita, Brian Y. H. Lam, Marcella Ma, Wendy N. Cooper, Antonio Vidal-Puig, Susan E. Ozanne, Gema Medina-Gómez, Miguel Constância. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet 2020 Oct 15;16(10):e1009069. doi: 10.1371/journal.pgen.1009069. |
| Start Year | 2019 |
| Description | "Deep history of obesity and metabolism" event, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk at multidisciplinary event about the origins of obesity from a historical, archaeological and scientific perspective attended by academics from various institutions and fields. Dr Laura Dearden |
| Year(s) Of Engagement Activity | 2021 |
| Description | 16th SBAN National Congress "Developmental programming by maternal obesity: a window of opportunity to improve the health of mother and child" Sao Paulo, Brazil 11th-13th August 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Developmental programming by maternal obesity: a window of opportunity to improve the health of mother and child" |
| Year(s) Of Engagement Activity | 2022 |
| Description | 16th SBAN National Congress "Epigenetic mechanisms linking obesity during pregnancy to poor metabolic health in the offspring" Sao Paulo, Brazil 11th-13th August 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled "Epigenetic mechanisms linking obesity during pregnancy to poor metabolic health in the offspring" |
| Year(s) Of Engagement Activity | 2022 |
| Description | 2019 79th ADA Scientific Sessions, San Francisco, USA 7th - 11th June 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I attended syposiums and scientific sessions, asking questions and networking during breaks. I also presented a poster summarizing my recent research into programming of NASH by miRNA expression. The intention of all these activities was to get a better understanding of the cutting edge science in the diabetes field and to develop my networking. Dr Lucas Pantaleao |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://professional.diabetes.org/meeting/scientific-sessions/79th-scientific-sessions |
| Description | 2019 Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We encouraged the public to engage in several educational activities such as an artificial heart rate control game and leaflets hand-off. We intended to raise awareness about preventive medicine to the heart health. Dr Lucas Pantaleao |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.sciencefestival.cam.ac.uk/ |
| Description | 2019 Sino-UK Cardiovascular Diseases Symposium Nanjing, China 24th May 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming of cardiometabolic disease by maternal diet-induced obesity: a developing problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | 3rd Sao Paulo Graduate Course on Developmental Programming. Sao Paulo, Brazil 5-9 November 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk entitled 'Developmental Origins of Health and Disease: 25 years in the making. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 5th International Conference on Nutrition and Growth, Paris, 1-3 March 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker, talk entitled Impact of Preconception and Pregnancy Diets |
| Year(s) Of Engagement Activity | 2018 |
| Description | 66th Annual Scientific Meeting Society for Reproductive Investigation, Paris 2019 - Miguel Constancia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Session on Fetal signals regulating placental function (Placental Satellite Meeting) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.sri-online.org/UserFiles/2019%20AM/Program/AM19FinalProgram.pdf |
| Description | 6th International Achieving Improved Outcomes in Neonatology and Academic Association Joint Conference. Cardiff Wales 13-15th March 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Short and long-term impact of maternal obesity on offspring. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 75th Anniversary Laboratorios Ordesa: Present and future of infant nutrition, Barcelona, 26027 April 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker: Mechanisms underlying programming by early nutrition. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 78th Scientific Sessions of the American Diabetes Association, Orlando USA, 22-26 June 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker: Obesity during pregnancy: long-term cardio-metabolic consequences for mother and child. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 7th Mediterranean Neuroscience Conference Marrakech, Morocco 23rd-27th June 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Nutritional programming of cardio-metabolic disease by maternal obesity |
| Year(s) Of Engagement Activity | 2019 |
| Description | 80th Scientific Sessions of the American Diabetes Association (virtual) 12-16 June 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Sex differences in metabolic programming by maternal obesity. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Advances at the interface between Metabolism and Epigenetics, Cambridge UK, 2019 (Miguel Constancia -co-organiser) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The intended purpose was to gather a number of world-leaders to discuss the latest developments in metabolism and epigenetics, from cellular metabolism, to normal physiology and disease |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.metabolism.cam.ac.uk/advances-at-the-interface-between-metabolism-and-epigenetics/ |
| Description | Advances at the interface between metabolism and epigenetics, 16-17 January 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-authored a prize winning poster (presenting author-Tessa Bertozzi), attended talks and discussed methodologies. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.metabolism.cam.ac.uk/event/advances-at-the-interface-between-metabolism-and-epigenetics/ |
| Description | American Heart Association Scientific Sessions 2019 Transforming the Cardiovascular Health of Youth for Generations to come. Philadelphia USA 16th -19th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Cardiovascular health and Risk - Molecular Mechanisms |
| Year(s) Of Engagement Activity | 2019 |
| Description | Angers annual summer school 2019, Angers France 27th June 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Invited lecture. Title: What is fetal programming? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Annual Covian Symposium (virtual) Ribeiro Preto, Brazil 1 October 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Nutritional programming of cardio-metabolic health: a developing problem |
| Year(s) Of Engagement Activity | 2020 |
| Description | Annual Dutch Diabetes Research Meeting 2019, Oosterbeek 28th-29th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming of cardio-metabolic health by maternal obesity: a developing problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | Astra Zeneca 'Meet the Neighbours' site tour 24th January 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Tour of the new Astra Zeneca headquarters site on the Cambridge Biomedical Campus. AZ are industry partners. |
| Year(s) Of Engagement Activity | 2020 |
| Description | BHF CRE Annual Symposium 2019 Cambridge UK 9th May 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming of cardio-metabolic disease by maternal diet-induced obesity: a developing problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | BHF Cambridge CRE Annual Research Symposium Poster judge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Denise Fernandez-Twinn: Judging the merit and scientific rigour of oral presentations in Cardiometabolic Medicine |
| Year(s) Of Engagement Activity | 2022 |
| Description | BHF Cambridge CRE Annual Research Symposium, Cambridge, April 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Invited poster judge at symposium, judging the merit and scientific rigour of oral presentations in Cardiometabolic Medicine. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2023 |
| Description | BHF Cambridge CRE Annual Symposium Programming by maternal obesity: a road to poor cardio-metabolic health. Cambridge UK 28th April 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Programming by maternal obesity: a road to poor cardio-metabolic health |
| Year(s) Of Engagement Activity | 2022 |
| Description | BHF Corporate sponsor event |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Showing fundraising groups from the BHF what research the money they raise is going toward. This was to remind them why they are fundraising and helps to increase enthusiasm. In our case, we wanted to spread the message that things in the womb have an impact on long-term cardiovascular disease risk. Josca Schoonejans, PhD student |
| Year(s) Of Engagement Activity | 2018 |
| Description | BHF Student conference 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Annual conference of the 4-year BHF-funded PhD programme at a national level. Talks and poster presentations given by PhD students from all over the country. Josca Schoonejans |
| Year(s) Of Engagement Activity | 2019 |
| Description | BHF student conference 2018 (Edinburgh) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented my research as a talk at a conference. Talks sessions allowed for questions and discussion from audience with a wide background of cardiovascular research Jessica Beeson |
| Year(s) Of Engagement Activity | 2018 |
| Description | BHF supporters day 2018- Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Third sector organisations |
| Results and Impact | Presented a poster at a BHF supporters event. Fundraisers/supporters of the BHF were invited to learn about BHF funded research. Also help to host a lab tour to show how research is being done. Representatives of the charity were also in attendance. Jessica Beeson |
| Year(s) Of Engagement Activity | 2018 |
| Description | British Heart Foundation Cambridge CRE Research Symposium poster presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A virtual poster presentation to researchers based in Cambridge in the field of cardiovascular research presenting data from my project with a focus on echocardiography analysis and data. Isabella Inzani |
| Year(s) Of Engagement Activity | 2021 |
| Description | British Heart Foundation Summer Seminar 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Annual seminar of the 4-year BHF-funded PhD programme in Cambridge. Talks given by PhD students to give heads of programme an overview of the variety of research the programme funds. Josca Schoonejans |
| Year(s) Of Engagement Activity | 2019 |
| Description | British Heart Foundation supporters event and laboratory tour |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Event was for British Heart Foundation volunteers to observe what research is currently happening at the University of Cambridge Biomedical Campus. They were given lab tours from multiple labs (including ours) where we presented data from our research and engaged in hands-on activities. Dr Heather Blackmore |
| Year(s) Of Engagement Activity | 2018 |
| Description | British Society for Neuroendocrinology, Early Career Researcher - first webinar - (virtual) 5th June 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I performed a virtual oral presentation of 10 min to describe the effects of maternal obesity in programming the Hypothalamic miR-505-5p expression, which may cause an impact on long-term hypothalamic fatty acid sensing mechanisms. Isadora Furigo |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.neuroendo.org.uk/page.php?item_name=Early+Career+Researcher+Hub |
| Description | Cambridge Festival 29th March 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk title: "How nutrition and growth in the womb influences our risk of type 2 diabetes" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Cambridge Reproductive Forum, Cambridge, United Kingdom (virtual) 15th October 2020 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Deliver presentation to introduce the Ozanne lab research activities. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.repro.cam.ac.uk/events/cambridge-reproduction-forum-michaelmas-2020 |
| Description | Cambridge SRI summer school in reproduction "Interventions during obese pregnancy: a window of opportunity to improve the health of two generations. Cambridge (virtual) 20th-21st September 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Interventions during obese pregnancy: a window of opportunity to improve the health of two generations. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Introducing children to the topic of metabolic science. Laura Kuskinski |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Science Festival - Ionel Sandovici |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Escape room: Research breakthrough! (9 April 2022, Nuns Way Pavillion, Cambridge) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.festival.cam.ac.uk/ |
| Description | Cambridge Science Festival - Meet the Scientist |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Drop-in session for the general public to meet a scientist to find out about the work that we do and to ask questions. Lisa Nicholas, C J Martin Fellow |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | I helped man the BHF cardiovascular stand at the Cambridge Science Festival, helping out with various activities. The aim was to teach visitors from the general public (incl. children) about the basics of cardiovascular health and to make them enthusiastic about science. Josca Schoonejans, PhD student |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge science festival: Rising stars event |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Designed own hands on engagement activity communicating my research for the Cambridge Science Festival. Attended a public engagement course to learn important engagement skills. Ran stall with activity for whole day engaging with children and parents. Jessica Beeson |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencefestival.cam.ac.uk/events/rising-stars |
| Description | Cardiology User meeting, Fujifilm VisualSonics, London, Sep 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended talks and discussed methodologies Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cardiovascular Seminar Series. Programming of cardio-metabolic health by exposure to an in utero obesogenic environment. Manchester, November 16th 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk: Programming of cardio-metabolic health by exposure to an in utero obesogenic environment: a window of opportunity to improve the health of two generations. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Centre for Trophoblast Research (CTR) half-day symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | The symposium was aimed at researchers working on the placenta and covered a broad range of different research interests. I presented my research in a 10 minute presentation, followed by 5 minutes for questions. This was the first time presenting a talk (without pre-recording) via zoom, which was a good practice. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2017,2021 |
| Description | Centre for Trophoblast Research Away Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Discussions with attendees at CTR away day |
| Year(s) Of Engagement Activity | 2022 |
| Description | Centre for Trophoblast Research Away Day, 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Attended talks and exchanged information. Had discussions with attendees. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2023 |
| Description | Centre for trophoblast research (CTR) half-day symposium, Cambridge, 21 February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | The symposium was aimed at researchers working on the placenta and covered a broad range of different research interests. I presented my research in a 10 minute presentation, followed by 5 minutes for questions. It was very helpful to practice giving a talk at a conference. I got a lot of helpful, interesting and motivating feedback. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://twitter.com/ozannelab/status/1230823653685809154 |
| Description | Coventry University Institute of Health & Wellbeing Seminar Series. Coventry, UK, 20th February 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk: Programming of cardiometabolic health by maternal over-nutrition during pregnancy: a developing obesity crisis |
| Year(s) Of Engagement Activity | 2024 |
| Description | DOHAD World Congress 2022 Maternal Metformin Intervention During Glucose-Intolerant Obese Mouse Pregnancy Has Sex-Specific Effects on Adiposity And Cardiometabolic Health Of Aged Offspring, August 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk by Dr Josca Schoonejans entitled Maternal Metformin Intervention During Glucose-Intolerant Obese Mouse Pregnancy Has Sex-Specific Effects on Adiposity And Cardiometabolic Health Of Aged Offspring |
| Year(s) Of Engagement Activity | 2022 |
| Description | DOHAD World Congress 2022 poster presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Denise Fernandez Twinn: open discussion of poster to a wide audience. Poster title: PLACENTA LIPIDS AS SEX-SPECIFIC MEDIATORS OF INSULIN ACTION ON FETAL GROWTH |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dohad2022.com/welcome |
| Description | Danish Diabetes Association Childhood Obesity Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at conference designed to inspire new PhD students from Denmark and the UK Dr Laura Dearden |
| Year(s) Of Engagement Activity | 2021 |
| Description | Danish Diabetes Association Childhood Obesity Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at conference designed to inspire new PhD students from Denmark and the UK |
| Year(s) Of Engagement Activity | 2021 |
| Description | Deep history of obesity, Cambridge 26th May 2021 (Virtual) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Session chair and meeting organising committee. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Deep history of obesity, Cambridge 26th May 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Multidisciplinary event about the origins of obesity from a historical, archeological and scientific perspective attended by academics from various institutions and fields. Josca Schoonejans |
| Year(s) Of Engagement Activity | 2021 |
| Description | Developmental Origins of Health and Disease (DOHaD) World Congress, October 2019, Melbourne, Australia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | In a poster session I presented a poster with my work. I also gave a short presentations (3 minutes) to pitch my poster. It was very helpful to practice to give a first little talk at a big conference and helped to engage and discuss my project with people afterwards. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://dohadsoc.org/dohad-world-congress/ |
| Description | Developmental Origins of Health and Disease 11th World Congress. Picking apart obesity and diabetes in pregnancy, Melbourne Australia 20th-23rd October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker and Council Member. Talk title: Is it maternal hyperglycaemia or is it obesity that affects offspring health? |
| Year(s) Of Engagement Activity | 2019 |
| Description | DoHAD World Congress, 20-23rd October 2019, Melbourne |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Largest international congress focusing on developmental programming. Other researchers and clinicians attended - hopefully the work is picked up on and may lead to influencing medical decision making in the long run. Josca Schoonejans |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.cvent.com/events/2019-dohad-international/custom-22-828d23c3caf043c0ae6449de8d7bfbc3.aspx |
| Description | DoHAD World Congress, 20-23rd October 2019, Melbourne |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I attended symposiums and scientific sessions, asking questions and networking during breaks. I also presented a poster summarizing my recent research into programming of NASH by miRNA expression. The intention of all these activities was to get a better understanding of the cutting edge science in the diabetes field and to develop my networking. Dr Lucas Pantaleao |
| Year(s) Of Engagement Activity | 2019 |
| Description | DoHAD World Congress, 20-23rd October 2019, Melbourne |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presented a poster, title: |
| Year(s) Of Engagement Activity | 2019 |
| Description | EB2022 Philadelphia Interventions during obese pregnancy: a window of opportunity to improve the health of two generations. 2nd-5th April 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Interventions during obese pregnancy: a window of opportunity to improve the health of two generations |
| Year(s) Of Engagement Activity | 2022 |
| Description | EMBO/EMBL Symposia - Ionel Sandovici |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation on 'IGF2 is a key feto-placental communication signal that maintains normal growth and development' |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.embl.org/about/info/course-and-conference-office/events/ees22-02/ |
| Description | European Brain & Behaviour Society (EBBS) symposium, Lausanne, Switzerland 4th - 7th September 2021.(virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Programming of metabolic health by maternal obesity- are effects sex-specific? |
| Year(s) Of Engagement Activity | 2021 |
| Description | European Congress of Endocrinology 2021, 22-26th May 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Programming of cardio-metabolic health: the role of maternal and fetal hyperinsulinaemia. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Experimental Biology 2018, San Diego 21-25 April 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker: Mechanisms underlying nutritional programming of cardio-metabolic health. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Experimental Biology 2021, 27-30th April 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Maternal diet regulates insulin action by epigenetic mechanisms. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Experimental biology 2022 Poster: Metformin Exposure in utero Programmes Hypertension in a Sex-Specific Manner in Adult Offspring of Obese Mice |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation by Phoebe Wilsmore title: Metformin Exposure in utero Programmes Hypertension in a Sex-Specific Manner in Adult Offspring of Obese Mice |
| Year(s) Of Engagement Activity | 2022 |
| Description | Fetal and Neonatal Physiological Society (FNPS) annual meeting talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A presentation at the FNPS international symposium presenting my research to scientists in the field of developmental biology. A 10 minute talk. Isabella Inzani |
| Year(s) Of Engagement Activity | 2021 |
| Description | Genomic Imprinting - from Biology to Disease 2020 virtual conference; 28 September - 01 October 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attend talks and discuss new approaches; presented a poster which won the poster prize; networking opportunities. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://wellcomegenomecampus.org/coursesandconferences |
| Description | Gordon Research Conference - Miguel Constancia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker on the topic of Inter-organ communication and IGFs |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.grc.org/igf-and-insulin-system-in-physiology-and-disease-conference/2023/ |
| Description | Harold Hamm Diabetes Centre Metabolic Research Conference, (virtual) Oklahoma City USA, 2nd November 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Programming by maternal obesity: a developing problem |
| Year(s) Of Engagement Activity | 2020 |
| Description | IADPSG Obesity during pregnancy: a window of opportunity to improve the health of two generations. Sydney 17th-20th November 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk entitled Obesity during pregnancy: a window of opportunity to improve the health of two generations. |
| Year(s) Of Engagement Activity | 2022 |
| Description | IMS-MRL Annual Research Retreat, Robinson College, University of Cambridge, Cambridge. 1st February 2024 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Judging the merit and scientific rigour of poster presentations. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2024 |
| Description | IMS-MRL Annual Research Retreat, Robinson College, University of Cambridge, Cambridge. 1st February 2024 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Judging the merit and scientific rigour of poster presentations. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2024 |
| Description | IPWSO conference 2022 - Miguel Constancia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited keynote speaker on the topic of Neuroplacentology, with the aim of educating and disseminating information about potential roles of placenta in Prader-Willi phenotypic manifeestations |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ipwso.org/news-events/conferences/ |
| Description | In-Utero MRI 2020 Queen Anne's College Oxford, UK 8th - 10th January 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Early Programming |
| Year(s) Of Engagement Activity | 2019 |
| Description | Institute of Metabolic Science Covid Club Seminars, University of Cambridge, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Informal discussion within the department about the role of sex differences in studying obesity and metabolism |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolic Science Covid Club Seminars, University of Cambridge, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Informal discussion within the department about the role of sex differences in studying obesity and metabolism Josca Schoonejans |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolic Science online academy for work experience pupils in COVID times, Cambridge, United Kingdom 2020 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The so-called 'online academy' will be launched at the end of April 2021 and will be in sessions after school under the supervision of the teacher. Small groups of students (up to 10) will be engaged in interactive sessions regarding the topic "Why are some people severely obese? - The story of leptin". One session will be aimed to provide background. The other sessions will enable the student to do easy experiments in their classroom with online supervision from us, the researchers. And a final session will allow the students to ask career and university course related questions. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolic Science online academy for work experience pupils in Covid times, University of Cambridge, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Due to the pandemic, many schools had to cancel the "work experience" programmes they usually run. A small group of students and post-docs in our department designed a 5 x 2.5 hour session learning and research course that could be delivered entirely virtually to a local school, with three main aims: 1) The students learn new biological information that is related to but beyond their curriculum 2) The students gain practical experience performing common lab techniques that is usually only possible if completing a placement in a lab 3) The students are able to ask questions about and get excited by the idea of studying and working in science themselves The students learnt about the discovery, function and clinical impact of the hormone leptin, they carried out (fake) ELISAs to test for leptin in a range of samples, and used DNA sequencing software to search for and identify mutations in provided leptin gene sequences. We then led a discussion and Q&A session where the group talked not only about the specific science we had been working on, but also explored wider conversations about metabolic research, and discussed different career paths in science. We conducted a survey at the end of the academy and found that all three of our aims had been met. We hope to adapt the IMS Online Academy and run it again to more schools and/or year groups in the future. Phoebe Wilsmore |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolic Science online academy for work experience pupils in Covid times, University of Cambridge, 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The so-called online academy will be launched at the end of April and will be in sessions after school under the supervision of the teacher. Small groups of students (up to 10) will be engaged in interactive sessions regarding the topic "Why are some people severely obese? - The story of leptin". One session will be aimed to provide background. The other sessions will enable the student to do easy experiments in their classroom with online supervision from us, the researchers. And a final session will allow the students to ask career and university course related questions. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolic Science student symposium, University of Cambridge, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A presentation to postgraduate students at the IMS-MRL presenting data from my PhD as part of the annual student symposium. Isabella Inzani |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolic Science, University of Cambridge student symposium 13th July 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Delivery of 15 minute talk outlining my current research. Phoebe Wilsmore |
| Year(s) Of Engagement Activity | 2021 |
| Description | Institute of Metabolism and Systems Research, Birmingham, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk as part of internal seminar series of the Institute for Metabolic and Systems research in Birmingham. So any interested researcher from the institute will be able to listen to the talk in December. This will be a great opportunity to present the work from my project and my lab to another institute working on similar topics. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2021 |
| Description | International DOHaD 2019 Congress, Oct 20-23 2019, Melbourne |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attended talks and discussed new approaches; presented a poster; networking opportunities. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://dohadsoc.org/dohad-world-congress/ |
| Description | Invited online seminar by Miguel Constancia @ Unidade de Endocrinologia Pediatrica de la Pontificia Universidad Catolica de Chile |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Research Seminar on Maternal and Fetal genomes interplay |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited online seminar by Miguel Constancia @ the College of Health and Life Sciences Seminar Series, Hamad Bin Khalifa University, Doha, Qatar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Research talk on Epigenetic Programming of growth and metabolism |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited online seminar by Miguel Constancia @ the National Taiwan University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Research seminar on Epigenetic Programming of Growth and Metabolism |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited online speaker - Ionel Sandovici - @ 2nd International Conference on Cell and Experimental Biology (CEB-2021) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture titled: Novel insights into the regulation of pancreas development and function by the imprinted Igf2 gene |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker Satellite Meeting of the 66th Annual Scientific Meeting (Society for Reproductive Investigation) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker on the session 'The Placenta: The Pregnancy Communication Hub' (66th SRI Annual Scientific Meeting - Paris) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.sri-online.org/meetings-calendar/2019/program/satellite-meetings/placenta-satellite-meet... |
| Description | Joint Meeting of BSN and SNE |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk at conference to share recent data. Dr Laura Dearden |
| Year(s) Of Engagement Activity | 2021 |
| Description | King's College London internal seminar, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of our most recently published paper to my new research group (approx 20 attendees) Dr Laura Dearden |
| Year(s) Of Engagement Activity | 2021 |
| Description | King's College London, internal presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of our most recently published paper to my new research group (approx 20 attendees) Josca Schoonejans |
| Year(s) Of Engagement Activity | 2021 |
| Description | Leckhampton Society, University of Cambridge, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Public Engagement initiative from the postgraduate community of Corpus Christi College, Cambridge. Students at the College present their work to fellow students who are not necessarily in their field. Josca Schoonejans |
| Year(s) Of Engagement Activity | 2019 |
| Description | Life Lab for European Researcher's Night 2019, Ely Cathedral |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This Life Lab event was an event for the general public to learn about biology and how science works, a lot of activities were hands-on and gave the visitors (mainly families) a chance to explore the world of science. We adapted an activity we used for the MRC Science Festival in schools (see previous entry). An animation was designed by a company to visualize the background of our activity (obesity in dogs as an example to explain genetic variation and how to analyse it). Visitors were then able to put on a labcoat, use a pipette and load samples onto a DNA electrophoresis gel themselves. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.elycathedral.org/events/lifelab-in-ely-cathedral |
| Description | MRC Festival, 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | For the MRC Science Festival a group of researchers from the institute went to two schools (Ely College and North Cambridge academy) to engage with classes of 13 - 14 year olds. We planned and organised a lab activity for the students so that they could load DNA electrophoresis gels themselves and get a feel for basic techniques used in research. The activity was centred around obesity in dogs as an example to show how genetic variation/mutations can influence behaviour. We showed how these genetic differences can be detected by isolating DNA from the saliva of dogs, treating it with a restriction enzyme and analysing it on an electrophoresis gel. The activity led to an understanding that our DNA builds the instructions for our body to make all essential proteins in our body. It showed that mutations can alter the functions of these proteins and that scientists can identify these mutations. It was a very interesting experience and the students were very engaged. It was interesting and motivating to see that the students came up with very relevant and good questions. And most of them enjoyed pipetting for the first time. In addition to this activity two other departments ran sessions with the students as well. The feedback from the teachers was very positive and they were asking whether this can be run again. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://mrc.ukri.org/about/getting-involved/mrcfestival/ |
| Description | MRC Symposium, MRC Centre for Reproductive Health, Edinburgh 24th February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Mechanisms underlying the programming of cardio-metabolic health by maternal obesity |
| Year(s) Of Engagement Activity | 2020 |
| Description | Mancunian Skin Club Annual meeting. In utero nutritional stress and ageing. Manchester UK 26th-27th September 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled In utero nutritional stress and ageing. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Mechanisms and evolution of intergenerational change 2019, Wellcome Genome Campus. Hinxton UK 24th -26th September 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming by maternal over-nutrition - a plentiful problem |
| Year(s) Of Engagement Activity | 2019 |
| Description | Metabolic Network - Danish Diabetes Association conference, 'Metabolic Aspects of the Brain Muscle Axis' 3-4 September 2020, Cambridge, UK (virtual) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | In an online poster session I presented the work of my PhD project. It was a helpful experience to present online for the first time and a lot of time was allowed for questions which led to interesting discussions. Many sessions were in a workshop-format allowing interactive discussions and getting to know new people. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.metabolism.cam.ac.uk/metabolic-aspects-of-the-brain-muscle-axis-3-4-september-2020/ |
| Description | Metabolism Month, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 16th March 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | "Programming of Cardio-Metabolic Health by Maternal Obesity: a developing crisis" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Molecular Biology Applied to Nutritional Genomics course, Teresina, Brazil |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Speaker in the graduate course Molecular Biology Applied to Nutritional Genomics with the theme: Molecular Biology Techniques - Luciferase Assay and CRISPR. I gave a talk focused on techniques employed in our laboratory to graduate students in an University in a developing country. This engagement potentially enabled the students to use these techniques in their local research. Dr Lucas Pantaleao |
| Year(s) Of Engagement Activity | 2021 |
| Description | National Tutoring Programme, 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Based on a given handbook I will tutor 6 students for a few months in biology. In the first tutorial the needs of the students were identified so that we can work on that basis to catch up on the school content. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2019,2021 |
| Description | Neuroendo celebrate- British Society for Neuroendocrinology Conference 2019, Glasgow, 9th December 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I performed a poster presentation to describe the expression of microRNA 505-5p in neuronal cell culture after treatments that mimic the obesogenic intrauterine environment. Dr Isadora Furigo |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.neuroendo.org.uk/vendor/ckfinder/userfiles/files/ECR_JNE30_AbstractBooklet_4Dec19.pdf |
| Description | Neuroscience of Energy Balance Conference (NEB 2019), Manchester 3rd December 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I performed an oral presentation of 10 min to describe the effects of maternal obesity in programming the Hypothalamic miR-505-5p expression, may causing an impact on long-term hypothalamic fatty acid sensing mechanisms. Dr. Isadora Furigo |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://nebconference2019.com |
| Description | New Insights into Placental Small Extracellular Vesicles in Maternal-Fetal Communication |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Seminar, presentations and discussion. Dr Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2021 |
| Description | Nutrition Society Winter Conference 7th-8th December 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Nutrition Society Winter Conference, Royal Society, London, UK (virtual) Programming by maternal obesity: a pathway to poor cardio-metabolic health. 7th-8th December 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Nutrition and Health Event Cambridge Food Security Forum and EIT Food Initiative, St John's College Divinity School, Cambridge, 15th August 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation on the panel for this event. |
| Year(s) Of Engagement Activity | 2019 |
| Description | OCDEM Seminar, Oxford Centre for Diabetes, Endocrinology and Metabolism Oxford UK 20th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker. Talk title: Programming of cardio-metabolic disease by maternal over-nutrition: a developing crisis |
| Year(s) Of Engagement Activity | 2019 |
| Description | Obesity Week 2019 Las Vegas, USA 3rd-7th November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title? Is sugar an epigenetic trigger for obesity? |
| Year(s) Of Engagement Activity | 2019 |
| Description | Oregon Health & Science University, Center for Developmental Health Developmental Origins of Health and Disease (DOHaD) Summer Course, Oregon, USA, 5th August 2021 (virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Programming and type 2 diabetes: role of epigenetics. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Oxidative Stress and Disease Gordon Conference, Ventura USA 17th - 21st March 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Redox metabolomics and transcriptomics in metabolic disease phenotyping. |
| Year(s) Of Engagement Activity | 2019 |
| Description | PDN Foster talk, Department of Physiology, Development & Neuroscience, University of Cambridge, 20th February 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk: Nutritional programming by maternal over-nutrition: a developing obesity crisis. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Physiology Society satellite meeting "The placenta and maternal metabolic regulation in health and disease", Aberdeen, 7th of July 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | In a poster session I presented a poster with my work. It was very helpful to practice the presentation of a poster. Additionally lots of helpful feedback was received as the participants were all experts in my field. This led to interesting and helpful discussions. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.physoc.org/events/physiology2019/#tab-04 |
| Description | Pint of Science 2022 - Miguel Constancia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk about rare genomic diseases, with a focus on imprinting human disorders |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.facebook.com/pintofscience/ |
| Description | Poster Presentation, selected from abstracts for short oral presentation, by Denise Fernandez-Twinn @ Genomic Imprinting conference 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation prize winner: Denise S. Fernandez-Twinn, Ionel Sandovici, Niamh Campbell, Wendy N. Cooper, Ilona Zvetkova, Yoichi Sekita, Lila M. Oyama, Richard G. Kay, Gemma V. Brierley, Haydn Prosser, Katharina Hoelle, Noel Smith, David Ferland-McCollough, Martin Bushell, Anne Willis, Kenneth Siddle, Susan E. Ozanne & Miguel Constância: The imprinted microRNA-483 is a novel regulator of growth and metabolism. Genomic Imprinting - from Biology to Disease (Virtual Conference), 28-30 September 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://coursesandconferences.wellcomegenomecampus.org/our-events/genomic-imprinting-2020/ |
| Description | Poster presentation at Physiology 2019 8-10 July, Aberdeen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation: Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Dr Laura Kusinski |
| Year(s) Of Engagement Activity | 2019 |
| Description | Postgraduate course of Paediatrics, Influence of maternal obesity on the development of chromic non-communicable diseases in their children: findings from animal models. Universidade Federal de Sao Paulo, Brazil. 6th October 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Influence of maternal obesity on the development of chromic non-communicable diseases in their children: findings from animal models. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press Release University of Cambridge |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release by the University of Cambridge regarding a paper published in Developmental Cell. This paper received wide-spread media attention after the press-release (over 90 media outlets, with an altmetric score >790) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.communications.cam.ac.uk |
| Description | Press release for Mail online |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Provided commentary for national newspaper on a science story. Dr Laura Dearden |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.dailymail.co.uk/health/article-7772105/Obese-children-thinner-region-brain.html |
| Description | Rank Nutrition Symposium 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk entitled: Maternal obesity disrupts hypothalamic development and programs feeding behaviour in offspring. Prize for best talk. Dr Laura Dearden |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rank Prize Funds Mini Symposium on Obesity: from prevention to molecular mechanisms. Grasmere UK 15th-18th July 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Programming by maternal over-nutrition: a developing obesity crisis |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rank Prize mini symposium. Organiser/chairing two sessions "Exploring the impact of nutrition on the ageing process" Grasmere, 9th - 12th May 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Organiser/chairing two sessions "Exploring the impact of nutrition on the ageing process" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Research in Progress seminar, Institute of Metabolic Science, University of Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | I was a speaker in the Research in Progress series with the theme: Programming of miRNAs and liver disease Dr Lucas Pantaleao |
| Year(s) Of Engagement Activity | 2021 |
| Description | Research in progress internal seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Helped to present an research update within my research institute to colleagues. Audience was mixture of Professors, postdoctoral researchers and postgraduate students. Jessica Beeson |
| Year(s) Of Engagement Activity | 2018 |
| Description | Royal Society Causes of obesity: theories, conjectures and evidence. Early life impacts of maternal obesity. London UK 17-19th October 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk entitled Early life impacts of maternal obesity. Broadcast internationally and debate at end of conference |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society Frontiers of Science: Developmental Biology and Climate Science, 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Attend talks and discuss new approaches; presented a poster; networking opportunities 2 of which are potential new collaborations. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://royalsociety.org/science-events-and-lectures/for-scientists/ |
| Description | Royal Society meeting on Causes and Consequences of Obesity, London April 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Discussions with attendees. Attended talks and exchanged information. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2023 |
| Description | STEM for BRITAIN (presentation to Parliamentary and scientific committee) London, UK, Feb 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation to Parliamentary and Scientific Committee about impact of maternal obesity during pregnancy on offspring brain development. Networked with other young scientists from around UK and met senior scientists from Royal Society and politicians. Laura Dearden |
| Year(s) Of Engagement Activity | 2020 |
| Description | Selected talk, from submitted abstracts, by Ionel Sandovici @ Genomic Imprinting Conference 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Science communication to colleague scientists with an interest in Genomic Imprinting. The talk was awarded the Short Oral Presentation Prize (only one Prize awarded) at the virtual conference. Sandovici, I., Georgopoulou, A., Hufnagel, A.S., Schiefer, S.N., Gaudreau, C., Santos, F., Hoelle, K., Lam, B.Y.H., Yeo, G.S.H., Burling, K., López-Tello, J., Reiterer, M., Fowden, A.L., Burton, G.J., Branco, C.M., Sferruzzi-Perri, A.N., Constância, M.: The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Genomic Imprinting - from Biology to Disease (Virtual Conference), 28-30 September 2020 (Short Oral Presentation Prize winner). |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://coursesandconferences.wellcomegenomecampus.org/our-events/genomic-imprinting-2020/ |
| Description | Seminar to German Diabetes Centre research Training Group 6th October |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | German Diabetes Centre, Research Training Group RTG 2576, RTG 'Vivid' guest lecture, Programming of cardio-metabolic health by maternal obesity: can we intervene? Dusseldorf, Germany (virtual) 6th October 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Sex, Gender & Epigenetics Conference, Epigenetic mechanisms linking poor maternal nutrition during pregnancy to offspring cardio-metabolic health. Florence, Italy 12th-14th May 2022. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Epigenetic mechanisms linking poor maternal nutrition during pregnancy to offspring cardio-metabolic health. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Society for Endocrinology BES Conference. Glasgow, Scotland 19-21 November 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk entitled 'Impact of maternal diabetes on child health' |
| Year(s) Of Engagement Activity | 2018 |
| Description | Society for Maternal and Fetal Medicine 40th Annual Pregnancy Meeting Texas, USA 3rd - 8th February 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker. Talk title: Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry: systematic review and meta-analysis |
| Year(s) Of Engagement Activity | 2020 |
| Description | Student visit to Institute of Metabolic Science, University of Cambridge, 2023 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Students shadowed different members of the lab to gain an understanding of research life. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk at DOHaD World Congress 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Dr Lucas Pantalaeo presented a scientific talk on the contribution of miRNA-15b to the programming of cardiac disfunction |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dohad2022.com/ |
| Description | Talk at SONIC (Seminars to Optimize Networking, Innovation and Collaboration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Lucas Pantalaeo presented a scientific talk on sex-dependent changes to the cardiac lipidome by maternal diet-induced obesity |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.mrl.ims.cam.ac.uk/research/core-facilities/ |
| Description | Talk at SONIC (Seminars to Optimize Networking, Innovation and Collaboration) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Denise Fernandez- Twinn: Described body of published work in collaboration with the Core Lipidomics and Metabolomics Laboratory |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk by Ionel Sandovici, Department of Cellular and Developmental Biology, University of Bath (25 November 2020, via zoom) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited seminar by Prof. Andrew Ward titled 'The role of the imprinted Igf2 gene in pancreatic development and function' |
| Year(s) Of Engagement Activity | 2020 |
| Description | The Company of Biologists 'Developmental Metabolism and the Origins of Health and Disease Workshop. Obesity during pregnancy and offspring cardio-metabolic health- a window of opportunity to improve the health of two generations. Buxted Park, East Sussex, UK 24th -27th October 2022. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Obesity during pregnancy and offspring cardio-metabolic health- a window of opportunity to improve the health of two generations, as part of workshop |
| Year(s) Of Engagement Activity | 2022 |
| Description | The Human Placenta in Diabetes & Obesity, Danish Diabetes Association |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The workshop was centered around placental biology and pathology. It was a very interactive meeting with many interesting discussions, especially due to the input from clinicians. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2020 |
| Description | UCL Genetics, Evolution and Environment seminar series, Institute of Healthy Ageing UCL, London (virtual) 13th May 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Seminar title: Mechanisms underlying the developmental origins of cardio-metabolic health |
| Year(s) Of Engagement Activity | 2020 |
| Description | UKEV Forum, Sheffield, 11 Dec 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended talks and discussed methodologies |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ukev.org.uk/ukev-forum-2018/ |
| Description | UKEV, Sheffield (UK Society for Extracellular Vesicles), 11th December 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This was a conference annual event run by the UK Society for extracelluar vesicles. This was to gain an insight into this new field and to make new collaborations with researchers in this field. Laura Kusinski |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://drive.google.com/file/d/1O9I8nO7HgVkOi0jUnHmTakjAgrkClOA7/view |
| Description | UNIFESP graduate training course, Brazil June 9th 2021 (virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture title: Mechanisms of intrauterine programming of obesity and type 2 diabetes: are they preventable? |
| Year(s) Of Engagement Activity | 2021 |
| Description | Undergraduate talk, University of Cambridge Biological Sciences Society Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Isabella Inzani - to be completed |
| Year(s) Of Engagement Activity | 2017,2021 |
| Description | Universidade Federal de Sao Paulo (UNIFESP) Seminar Series "Programming by maternal obesity: state of the science and future directions" Sao Paulo, Brazil, 8th August 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled "Programming by maternal obesity: state of the science and future directions" |
| Year(s) Of Engagement Activity | 2022 |
| Description | University of Cambridge Biological Sciences Society event, Cambridge, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | A talk to undergraduate students at the University of Cambridge Biological Science Society explaining the aims of my research project with a focus on methodology and scientific approaches to answering research questions. Isabella Inzani |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Cambridge, Institute of Metabolic Science Student Symposium 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Annual symposium of the Institute of Metabolic Science in Cambridge. Talks given and posters presented by all students in the institute, to broadcast the variety of research in the institute. Attended by students and senior researchers. Josca Schoonejans |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of Nottingham Division of Medical Sciences External Seminar Series Event (Virtual), Nottingham, UK 29th January 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Programming by maternal obesity: a developing problem. (virtual) |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Nottingham Division of Medical Sciences External Seminar Series Event (virtual), 29th January 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk title: Programming by maternal obesity: a developing problem. |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Oulu Seminar Series Programming of cardio-metabolic health by maternal obesity during pregnancy: a developing problem. Oulu, Finland 21st June 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled Programming of cardio-metabolic health by maternal obesity during pregnancy: a developing problem. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Venice Maternal, Neonatal & Childhood Health Forum, Venice, Italy, 22nd March 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: "How does evidence on children's fat and muscle development contribute to the case for investment in MNCH after COVID-19?" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Visualsonics Multidimensional Cardiovascular Workshop (virtual) 3rd Nov 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attend talks and discuss methodologies. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2014,2020 |
| URL | https://www.visualsonics.com/event/workshops/multidimensional-cardiovascular-workshop-2020 |
| Description | Work experience |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | 1) A one- week opportunity for a Year 10-11 student to immerse in an experience of working in a laboratory-based research setting with exposure to learning from PhD students and post-doctoral staff. Exposure to weekly lab and institute-wide research seminars, both internal and external. 2) Part II Tripos students from the University of Cambridge are supervised over a whole term (usually Summer term) for their Part II project. Dr. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2018 |
| Description | Working within the Human Tissue Act, 19 September 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended talks and discussed methodologies. Denise Fernandez-Twinn |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://mrc.ukri.org/research/facilities-and-resources-for-researchers/regulatory-support-centre/ |
| Description | Workshop: The human placenta in diabetes and obesity (diabesity), Danish Diabetes Association (virtual) 22 September 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The workshop was centered around placental biology and pathology. It was a very interactive meeting with many interesting discussions, especially due to the input from clinicians. Antonia Hugnagel |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.danishdiabetesacademy.dk/events/workshop-human-placenta-diabetes-and-obesity-diabesity |
| Description | Written commentary on work in the Endocrinologist (Issue 128, Summer 2018) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Written article discussing the impact of obesity in pregnancy to be published online and in the Endocrinologist magazine. Dr Heather Blackmore |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.endocrinology.org/endocrinologist/128-summer18/features/obesity-in-pregnancy-is-the-next... |
| Description | XXII Lipid Meeting, Leipzig, Germany 13-15th December 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk: In utero priming of diabetes. |
| Year(s) Of Engagement Activity | 2023 |
| Description | iPlacenta Symposium on Novel perspectives in maternal and fetal health, 7th May 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk title: Exploring the consequences of obesity during pregnancy for mother and child: a window of opportunity. |
| Year(s) Of Engagement Activity | 2021 |
| Description | iPlacenta Symposium on Novel perspectives in maternal and fetal health, 7th May 2021 (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The symposium was for researchers working on the placenta and pregnancy and clinicans. iPlacenta is an EU network for early career researchers in placental research to improve collaboration and research in the field of placental research. I presented a 10 minute talk with 5 minutes of questions and won the runner-up early career researcher talk prize. Antonia Hufnagel |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.iplacenta.eu/symposium.html |