Epigenetic programming of metabolic health across the life-course

Lead Research Organisation: University of Cambridge

Abstract

We aim to understand why babies who are exposed to a poor diet in the womb are more likely to develop type 2 diabetes or become obese as adults. Obesity and associated conditions like type 2 diabetes are major health problems in the UK and western countries, influencing both quality and quantity of life. Approximately one third of the adult population in the UK are obese and over 4 million people in the UK are affected by diabetes. We know that how well a baby is nourished in the womb is one factor that influences how likely they are to develop type 2 diabetes and obesity as adults. Therefore, it is very important to understand how early diet has such effects as this may help us develop new medicines for these common conditions. We know that one way in which a poor diet during early life impacts on health is through “epigenetic” processes. This is the way the environment controls which parts of DNA are used to make proteins and therefore how well a cell works. Recent advances in genome research allow us to look at the epigenetic regulation of all the genes in our DNA (~22,000). In this project we will use these technological advances to identify faulty genes that cause metabolic diseases because of poor early diet.

Technical Summary

We aim to define the epigenetic mechanisms mediating the relationship between suboptimal nutrition in utero and metabolic disease in later life. It is well established that altered patterns of early growth, as a consequence of both in utero under-nutrition and over-nutrition are associated with increased risk of metabolic diseases such as type 2 diabetes and obesity in later life. These conditions are major health care issues of the 21stcentury in both the developed and developing world. Therefore, understanding mechanisms by which these conditions arise and which could therefore be targeted within intervention and prevention strategies could have a major impact. Although there is strong evidence, from human and animal studies that early diet, plays an important role in mediating these relationships, the precise molecular mechanisms by which diet during critical periods of development programmes metabolism and consequently influences long-term health remain poorly defined. Permanent changes in epigenetic regulation of gene expression have emerged as an important contributing mechanism. Our previous studies demonstrated that promotor-enhancer interactions and small non-coding RNAs such as miRNAs represent key nodes of epigenetic regulation leading to modulation of expression of complex gene networks. In the current proposal, using adipose tissue from well-established mouse models of developmental programming in combination with human biopsy material, we will apply state of the art epigenetic technology including promoter-capture Hi-C with complex bioinformatic analysis, to identify changes in 4D chromatin structure that mediate programming effects. Furthermore, we will establish if non-coding RNAs represent particular “hot spots” within the genome for such regulation. We will define the function of these non-coding RNAs and promotor-enhancer interactions in vitro using a combination of primary cell cultures and adipocyte cell lines and applying CRISPR-Cas9 genome editing technology. Our studies will therefore define novel programming mechanisms that are conserved between rodents and humans. Any programmed epigenetic changes that we identify could, in the future, be used prognostically, diagnostically and therapeutically to target individuals at risk of metabolic disease resulting from suboptimal early life programming. The findings could therefore help combat the growing burden of complex diseases such as type 2 diabetes.

Publications

10 25 50
 
Description Bioinformatic Analysis of PC-HiC data - Bori Mifsud PI 
Organisation Hamad bin Khalifa University
Country Qatar 
Sector Academic/University 
PI Contribution We have performed a genome-wide screen of promoter interactions, using PC-HiC, in a well established in vitro model of adipogenesis (mouse 3T3L1 cells)
Collaborator Contribution Bioinformatic analysis of the genome-wide PC-HiC screen using 'Gothic' as pipeline
Impact Presentation at the 2019 IMB Conference - Chromosome Territories & Nuclear Architecture, held from 30 October to 01 November 2019, at the Institute of Molecular Biology (IMB), Mainz, Germany.
Start Year 2018
 
Description Epigenome studies Human Obesity 
Organisation University of Porto
Department Abel Salazar Institute of Biomedical Sciences
Country Portugal 
Sector Public 
PI Contribution Expertise in Epigenetics; host lab of visiting scientists
Collaborator Contribution Collection of adipose tissue from obese people and lean controls
Impact n/a
Start Year 2018
 
Description 2019 79th ADA Scientific Sessions, San Francisco, USA 7th - 11th June 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I attended syposiums and scientific sessions, asking questions and networking during breaks. I also presented a poster summarizing my recent research into programming of NASH by miRNA expression. The intention of all these activities was to get a better understanding of the cutting edge science in the diabetes field and to develop my networking.

Dr Lucas Pantaleao
Year(s) Of Engagement Activity 2019
URL https://professional.diabetes.org/meeting/scientific-sessions/79th-scientific-sessions
 
Description 2019 Cambridge Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We encouraged the public to engage in several educational activities such as an artificial heart rate control game and leaflets hand-off. We intended to raise awareness about preventive medicine to the heart health.

Dr Lucas Pantaleao
Year(s) Of Engagement Activity 2019
URL http://www.sciencefestival.cam.ac.uk/
 
Description 2019 Sino-UK Cardiovascular Diseases Symposium Nanjing, China 24th May 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Programming of cardiometabolic disease by maternal diet-induced obesity: a developing problem
Year(s) Of Engagement Activity 2019
 
Description 3rd Sao Paulo Graduate Course on Developmental Programming. Sao Paulo, Brazil 5-9 November 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk entitled 'Developmental Origins of Health and Disease: 25 years in the making.
Year(s) Of Engagement Activity 2018
 
Description 66th Annual Scientific Meeting Society for Reproductive Investigation, Paris 2019 - Miguel Constancia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Session on Fetal signals regulating placental function (Placental Satellite Meeting)
Year(s) Of Engagement Activity 2019
URL https://www.sri-online.org/UserFiles/2019%20AM/Program/AM19FinalProgram.pdf
 
Description 6th International Achieving Improved Outcomes in Neonatology and Academic Association Joint Conference. Cardiff Wales 13-15th March 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Short and long-term impact of maternal obesity on offspring.
Year(s) Of Engagement Activity 2019
 
Description 75th Anniversary Laboratorios Ordesa: Present and future of infant nutrition, Barcelona, 26027 April 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker: Mechanisms underlying programming by early nutrition.
Year(s) Of Engagement Activity 2018
 
Description 78th Scientific Sessions of the American Diabetes Association, Orlando USA, 22-26 June 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker: Obesity during pregnancy: long-term cardio-metabolic consequences for mother and child.
Year(s) Of Engagement Activity 2018
 
Description 7th Mediterranean Neuroscience Conference Marrakech, Morocco 23rd-27th June 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Nutritional programming of cardio-metabolic disease by maternal obesity
Year(s) Of Engagement Activity 2019
 
Description Advances at the interface between Metabolism and Epigenetics, Cambridge UK, 2019 (Miguel Constancia -co-organiser) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The intended purpose was to gather a number of world-leaders to discuss the latest developments in metabolism and epigenetics, from cellular metabolism, to normal physiology and disease
Year(s) Of Engagement Activity 2019
URL http://www.metabolism.cam.ac.uk/advances-at-the-interface-between-metabolism-and-epigenetics/
 
Description Advances at the interface between metabolism and epigenetics, 16-17 January 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Co-authored a prize winning poster (presenting author-Tessa Bertozzi), attended talks and discussed methodologies.

Denise Fernandez-Twinn
Year(s) Of Engagement Activity 2019
URL http://www.metabolism.cam.ac.uk/event/advances-at-the-interface-between-metabolism-and-epigenetics/
 
Description American Heart Association Scientific Sessions 2019 Transforming the Cardiovascular Health of Youth for Generations to come. Philadelphia USA 16th -19th November 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Cardiovascular health and Risk - Molecular Mechanisms
Year(s) Of Engagement Activity 2019
 
Description Angers annual summer school 2019, Angers France 27th June 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Invited lecture. Title: What is fetal programming?
Year(s) Of Engagement Activity 2019
 
Description Annual Dutch Diabetes Research Meeting 2019, Oosterbeek 28th-29th November 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Programming of cardio-metabolic health by maternal obesity: a developing problem
Year(s) Of Engagement Activity 2019
 
Description Astra Zeneca 'Meet the Neighbours' site tour 24th January 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Tour of the new Astra Zeneca headquarters site on the Cambridge Biomedical Campus. AZ are industry partners.
Year(s) Of Engagement Activity 2020
 
Description BHF CRE Annual Symposium 2019 Cambridge UK 9th May 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Programming of cardio-metabolic disease by maternal diet-induced obesity: a developing problem
Year(s) Of Engagement Activity 2019
 
Description BHF Corporate sponsor event 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Showing fundraising groups from the BHF what research the money they raise is going toward. This was to remind them why they are fundraising and helps to increase enthusiasm. In our case, we wanted to spread the message that things in the womb have an impact on long-term cardiovascular disease risk.

Josca Schoonejans, PhD student
Year(s) Of Engagement Activity 2018
 
Description BHF Student conference 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Annual conference of the 4-year BHF-funded PhD programme at a national level. Talks and poster presentations given by PhD students from all over the country.

Josca Schoonejans
Year(s) Of Engagement Activity 2019
 
Description BHF student conference 2018 (Edinburgh) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Presented my research as a talk at a conference. Talks sessions allowed for questions and discussion from audience with a wide background of cardiovascular research

Jessica Beeson
Year(s) Of Engagement Activity 2018
 
Description BHF supporters day 2018- Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Presented a poster at a BHF supporters event. Fundraisers/supporters of the BHF were invited to learn about BHF funded research. Also help to host a lab tour to show how research is being done. Representatives of the charity were also in attendance.


Jessica Beeson
Year(s) Of Engagement Activity 2018
 
Description British Heart Foundation Summer Seminar 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Annual seminar of the 4-year BHF-funded PhD programme in Cambridge. Talks given by PhD students to give heads of programme an overview of the variety of research the programme funds.

Josca Schoonejans
Year(s) Of Engagement Activity 2019
 
Description British Heart Foundation supporters event and laboratory tour 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Event was for British Heart Foundation volunteers to observe what research is currently happening at the University of Cambridge Biomedical Campus. They were given lab tours from multiple labs (including ours) where we presented data from our research and engaged in hands-on activities.


Dr Heather Blackmore
Year(s) Of Engagement Activity 2018
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Introducing children to the topic of metabolic science.

Laura Kuskinski
Year(s) Of Engagement Activity 2019
 
Description Cambridge Science Festival - Meet the Scientist 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Drop-in session for the general public to meet a scientist to find out about the work that we do and to ask questions.


Lisa Nicholas, C J Martin Fellow
Year(s) Of Engagement Activity 2018
 
Description Cambridge Science Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact I helped man the BHF cardiovascular stand at the Cambridge Science Festival, helping out with various activities. The aim was to teach visitors from the general public (incl. children) about the basics of cardiovascular health and to make them enthusiastic about science.


Josca Schoonejans, PhD student
Year(s) Of Engagement Activity 2017
 
Description Cambridge science festival: Rising stars event 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Designed own hands on engagement activity communicating my research for the Cambridge Science Festival. Attended a public engagement course to learn important engagement skills. Ran stall with activity for whole day engaging with children and parents.


Jessica Beeson
Year(s) Of Engagement Activity 2018
URL https://www.sciencefestival.cam.ac.uk/events/rising-stars
 
Description Cardiology User meeting, Fujifilm VisualSonics, London, Sep 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attended talks and discussed methodologies



Denise Fernandez-Twinn
Year(s) Of Engagement Activity 2018
 
Description Centre for trophoblast research (CTR) half-day symposium, Cambridge, 21 February 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The symposium was aimed at researchers working on the placenta and covered a broad range of different research interests. I presented my research in a 10 minute presentation, followed by 5 minutes for questions. It was very helpful to practice giving a talk at a conference. I got a lot of helpful, interesting and motivating feedback.

Antonia Hufnagel
Year(s) Of Engagement Activity 2020
URL https://twitter.com/ozannelab/status/1230823653685809154
 
Description Developmental Origins of Health and Disease (DOHaD) World Congress, October 2019, Melbourne, Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact In a poster session I presented a poster with my work. I also gave a short presentations (3 minutes) to pitch my poster. It was very helpful to practice to give a first little talk at a big conference and helped to engage and discuss my project with people afterwards.

Antonia Hufnagel
Year(s) Of Engagement Activity 2019
URL https://dohadsoc.org/dohad-world-congress/
 
Description Developmental Origins of Health and Disease 11th World Congress. Picking apart obesity and diabetes in pregnancy, Melbourne Australia 20th-23rd October 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker and Council Member. Talk title: Is it maternal hyperglycaemia or is it obesity that affects offspring health?
Year(s) Of Engagement Activity 2019
 
Description DoHAD World Congress, 20-23rd October 2019, Melbourne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presented a poster, title:
Year(s) Of Engagement Activity 2019
 
Description DoHAD World Congress, 20-23rd October 2019, Melbourne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Largest international congress focusing on developmental programming.

Other researchers and clinicians attended - hopefully the work is picked up on and may lead to influencing medical decision making in the long run.

Josca Schoonejans
Year(s) Of Engagement Activity 2019
URL http://www.cvent.com/events/2019-dohad-international/custom-22-828d23c3caf043c0ae6449de8d7bfbc3.aspx
 
Description DoHAD World Congress, 20-23rd October 2019, Melbourne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I attended symposiums and scientific sessions, asking questions and networking during breaks. I also presented a poster summarizing my recent research into programming of NASH by miRNA expression. The intention of all these activities was to get a better understanding of the cutting edge science in the diabetes field and to develop my networking.

Dr Lucas Pantaleao
Year(s) Of Engagement Activity 2019
 
Description Experimental Biology 2018, San Diego 21-25 April 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker: Mechanisms underlying nutritional programming of cardio-metabolic health.
Year(s) Of Engagement Activity 2018
 
Description In-Utero MRI 2020 Queen Anne's College Oxford, UK 8th - 10th January 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Early Programming
Year(s) Of Engagement Activity 2019
 
Description International DOHaD 2019 Congress, Oct 20-23 2019, Melbourne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Attended talks and discussed new approaches; presented a poster; networking opportunities.

Denise Fernandez-Twinn
Year(s) Of Engagement Activity 2019
URL https://dohadsoc.org/dohad-world-congress/
 
Description Leckhampton Society, University of Cambridge, 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Public Engagement initiative from the postgraduate community of Corpus Christi College, Cambridge. Students at the College present their work to fellow students who are not necessarily in their field.

Josca Schoonejans
Year(s) Of Engagement Activity 2019
 
Description Life Lab for European Researcher's Night 2019, Ely Cathedral 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This Life Lab event was an event for the general public to learn about biology and how science works, a lot of activities were hands-on and gave the visitors (mainly families) a chance to explore the world of science.
We adapted an activity we used for the MRC Science Festival in schools (see previous entry). An animation was designed by a company to visualize the background of our activity (obesity in dogs as an example to explain genetic variation and how to analyse it). Visitors were then able to put on a labcoat, use a pipette and load samples onto a DNA electrophoresis gel themselves.

Antonia Hufnagel
Year(s) Of Engagement Activity 2019
URL https://www.elycathedral.org/events/lifelab-in-ely-cathedral
 
Description MRC Festival, 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact For the MRC Science Festival a group of researchers from the institute went to two schools (Ely College and North Cambridge academy) to engage with classes of 13 - 14 year olds. We planned and organised a lab activity for the students so that they could load DNA electrophoresis gels themselves and get a feel for basic techniques used in research.

The activity was centred around obesity in dogs as an example to show how genetic variation/mutations can influence behaviour. We showed how these genetic differences can be detected by isolating DNA from the saliva of dogs, treating it with a restriction enzyme and analysing it on an electrophoresis gel. The activity led to an understanding that our DNA builds the instructions for our body to make all essential proteins in our body. It showed that mutations can alter the functions of these proteins and that scientists can identify these mutations.

It was a very interesting experience and the students were very engaged. It was interesting and motivating to see that the students came up with very relevant and good questions. And most of them enjoyed pipetting for the first time.

In addition to this activity two other departments ran sessions with the students as well. The feedback from the teachers was very positive and they were asking whether this can be run again.

Antonia Hufnagel
Year(s) Of Engagement Activity 2019
URL https://mrc.ukri.org/about/getting-involved/mrcfestival/
 
Description MRC Symposium, MRC Centre for Reproductive Health, Edinburgh 24th February 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Mechanisms underlying the programming of cardio-metabolic health by maternal obesity
Year(s) Of Engagement Activity 2020
 
Description Mechanisms and evolution of intergenerational change 2019, Wellcome Genome Campus. Hinxton UK 24th -26th September 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Programming by maternal over-nutrition - a plentiful problem
Year(s) Of Engagement Activity 2019
 
Description Neuroendo celebrate- British Society for Neuroendocrinology Conference 2019, Glasgow, 9th December 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I performed a poster presentation to describe the expression of microRNA 505-5p in neuronal cell culture after treatments that mimic the obesogenic intrauterine environment.

Dr Isadora Furigo
Year(s) Of Engagement Activity 2019
URL https://www.neuroendo.org.uk/vendor/ckfinder/userfiles/files/ECR_JNE30_AbstractBooklet_4Dec19.pdf
 
Description Neuroscience of Energy Balance Conference (NEB 2019), Manchester 3rd December 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I performed an oral presentation of 10 min to describe the effects of maternal obesity in programming the Hypothalamic miR-505-5p expression, may causing an impact on long-term hypothalamic fatty acid sensing mechanisms.

Dr. Isadora Furigo
Year(s) Of Engagement Activity 2019
URL https://nebconference2019.com
 
Description OCDEM Seminar, Oxford Centre for Diabetes, Endocrinology and Metabolism Oxford UK 20th November 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited speaker. Talk title: Programming of cardio-metabolic disease by maternal over-nutrition: a developing crisis
Year(s) Of Engagement Activity 2019
 
Description Obesity Week 2019 Las Vegas, USA 3rd-7th November 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title? Is sugar an epigenetic trigger for obesity?
Year(s) Of Engagement Activity 2019
 
Description Oxidative Stress and Disease Gordon Conference, Ventura USA 17th - 21st March 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Redox metabolomics and transcriptomics in metabolic disease phenotyping.
Year(s) Of Engagement Activity 2019
 
Description Physiology Society satellite meeting "The placenta and maternal metabolic regulation in health and disease", Aberdeen, 7th of July 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact In a poster session I presented a poster with my work. It was very helpful to practice the presentation of a poster. Additionally lots of helpful feedback was received as the participants were all experts in my field. This led to interesting and helpful discussions.

Antonia Hufnagel
Year(s) Of Engagement Activity 2019
URL https://www.physoc.org/events/physiology2019/#tab-04
 
Description Poster presentation at Physiology 2019 8-10 July, Aberdeen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Poster presentation: Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice.

Dr Laura Kusinski
Year(s) Of Engagement Activity 2019
 
Description Press release for Mail online 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Provided commentary for national newspaper on a science story.

Dr Laura Dearden
Year(s) Of Engagement Activity 2019
URL https://www.dailymail.co.uk/health/article-7772105/Obese-children-thinner-region-brain.html
 
Description Rank Nutrition Symposium 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker. Talk entitled: Maternal obesity disrupts hypothalamic development and programs feeding behaviour in offspring. Prize for best talk.

Dr Laura Dearden
Year(s) Of Engagement Activity 2019
 
Description Rank Prize Funds Mini Symposium on Obesity: from prevention to molecular mechanisms. Grasmere UK 15th-18th July 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Programming by maternal over-nutrition: a developing obesity crisis
Year(s) Of Engagement Activity 2019
 
Description Research in progress internal seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Helped to present an research update within my research institute to colleagues. Audience was mixture of Professors, postdoctoral researchers and postgraduate students.


Jessica Beeson
Year(s) Of Engagement Activity 2018
 
Description Royal Society Frontiers of Science: Developmental Biology and Climate Science, 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Attend talks and discuss new approaches; presented a poster; networking opportunities 2 of which are potential new collaborations.

Denise Fernandez-Twinn
Year(s) Of Engagement Activity 2019
URL https://royalsociety.org/science-events-and-lectures/for-scientists/
 
Description Society for Endocrinology BES Conference. Glasgow, Scotland 19-21 November 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk entitled 'Impact of maternal diabetes on child health'
Year(s) Of Engagement Activity 2018
 
Description Society for Maternal and Fetal Medicine 40th Annual Pregnancy Meeting Texas, USA 3rd - 8th February 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker. Talk title: Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry: systematic review and meta-analysis
Year(s) Of Engagement Activity 2020
 
Description UKEV Forum, Sheffield, 11 Dec 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attended talks and discussed methodologies
Year(s) Of Engagement Activity 2018
URL https://www.ukev.org.uk/ukev-forum-2018/
 
Description UKEV, Sheffield (UK Society for Extracellular Vesicles), 11th December 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This was a conference annual event run by the UK Society for extracelluar vesicles. This was to gain an insight into this new field and to make new collaborations with researchers in this field.

Laura Kusinski
Year(s) Of Engagement Activity 2018
URL https://drive.google.com/file/d/1O9I8nO7HgVkOi0jUnHmTakjAgrkClOA7/view
 
Description University of Cambridge, Institute of Metabolic Science Student Symposium 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Annual symposium of the Institute of Metabolic Science in Cambridge. Talks given and posters presented by all students in the institute, to broadcast the variety of research in the institute. Attended by students and senior researchers.

Josca Schoonejans
Year(s) Of Engagement Activity 2019
 
Description Work experience 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 1) A one- week opportunity for a Year 10-11 student to immerse in an experience of working in a laboratory-based research setting with exposure to learning from PhD students and post-doctoral staff. Exposure to weekly lab and institute-wide research seminars, both internal and external.

2) Part II Tripos students from the University of Cambridge are supervised over a whole term (usually Summer term) for their Part II project.

Dr. Denise Fernandez-Twinn
Year(s) Of Engagement Activity 2018
 
Description Working within the Human Tissue Act, 19 September 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Attended talks and discussed methodologies.

Denise Fernandez-Twinn
Year(s) Of Engagement Activity 2019
URL https://mrc.ukri.org/research/facilities-and-resources-for-researchers/regulatory-support-centre/
 
Description Written commentary on work in the Endocrinologist (Issue 128, Summer 2018) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Written article discussing the impact of obesity in pregnancy to be published online and in the Endocrinologist magazine.

Dr Heather Blackmore
Year(s) Of Engagement Activity 2018
URL https://www.endocrinology.org/endocrinologist/128-summer18/features/obesity-in-pregnancy-is-the-next...