China Kadoorie Biobank (CKB)
Lead Research Organisation:
University of Oxford
Department Name: UNLISTED
Abstract
Chronic diseases, such as stroke, heart disease, diabetes and cancer, are the leading causes of disability and death worldwide. Understanding what causes these diseases in different populations can lead to improvements in disease prevention, risk prediction and development of new treatments. One way of identifying causes of disease is through blood-based “prospective cohort” studies, in which large numbers of apparently healthy individuals from the general population are interviewed and measured, and have blood collected and stored for future tests of genetic and non-genetic biomarkers. The health status of the study participants is then monitored “prospectively” to see who develops what disease. When sufficiently large numbers of people have developed a particular disease (“cases”), their blood and other characteristics are compared with those from “controls” who have not developed the disease. We have established one of the world’s largest studies of this kind, involving 512,000 adults in China during 2004-08. After 10-year follow-up, large numbers of disease outcomes have been accumulated, which, together with other lifestyle, environment, genetic and blood biomarker data, will enable scientists to make important discoveries about genetic and non-genetic causes of many diseases. The study findings will help improve disease prevention, prediction and treatment, benefiting populations worldwide.
Technical Summary
Despite recent advances, our ability to prevent and treat many non-communicable chronic diseases (eg, stroke, heart disease, diabetes, cancer) is still limited. Understanding what causes these diseases in diverse populations can lead to improvements in risk prediction, treatment and disease prevention, and the development of “precision” medicines. CKB is a blood-based prospective cohort study of >512,000 adults, recruited from 10 diverse areas across China (during 2004-08), with extensive data collection at baseline and subsequent resurveys and long-term storage of biological samples. By 1.1.2017, ~45,000 deaths and ~1M coded episodes of hospitalisation of ~1500 major disease types have been recorded. These exposure and outcome data are complemented by cohort-wide genotyping (currently for 102,000 participants), large-scale whole genome sequencing, and conventional and multi-omics assays for nested case-control studies of specific diseases.
Over the next 5 years, the CKB will continue to develop, maintain, and share the resource through: (i) continued follow-up for disease events through linkage to mortality/morbidity registries and health insurance systems; (ii) ascertainment, adjudication and sub-phenotyping of major disease outcomes (e.g. stroke, IHD, cancer); (iii) resurvey of ~25,000 survivors with additional enhancements (e.g. accelerometers) and new sample collection (e.g. faecal/saliva samples); (iv) maintenance, enhancement and development of IT systems underpinning the infrastructure and coordination of the study; (v) processing, managing and sharing large and complex data with the wider research community; (vi) secure bio-repositories with DNA extraction and sample reformatting.
Based on the data collected or to be generated, a wide range of research will be undertaken, both for hypothesis testing and generating. These will include (i) prospective analyses of major risk factors with major diseases and their subtypes; (ii) Genome-wide association studies of traits, lifestyle factors and diseases; (iii) Mendelian randomisation studies of causal relevance of traits for major diseases; (iv) Phenome-wide association studies of functional variants to aid drug development; (v) Comprehensive assessment of the health effects of environmental exposures (eg, ambient and household air pollution, ambient temperature, and built environment) on major CVD and non-CVD. The research priority will be given to those that are considered to be novel and to have major public health impact.
CKB is a global resource with huge potential to improve our understanding of disease aetiology, risk prediction and development of new therapies. It will also complement other large prospective studies (eg, UK Biobank) enabling investigations into a different range of genetic and other exposures that may be rare or absent in Western populations.
Over the next 5 years, the CKB will continue to develop, maintain, and share the resource through: (i) continued follow-up for disease events through linkage to mortality/morbidity registries and health insurance systems; (ii) ascertainment, adjudication and sub-phenotyping of major disease outcomes (e.g. stroke, IHD, cancer); (iii) resurvey of ~25,000 survivors with additional enhancements (e.g. accelerometers) and new sample collection (e.g. faecal/saliva samples); (iv) maintenance, enhancement and development of IT systems underpinning the infrastructure and coordination of the study; (v) processing, managing and sharing large and complex data with the wider research community; (vi) secure bio-repositories with DNA extraction and sample reformatting.
Based on the data collected or to be generated, a wide range of research will be undertaken, both for hypothesis testing and generating. These will include (i) prospective analyses of major risk factors with major diseases and their subtypes; (ii) Genome-wide association studies of traits, lifestyle factors and diseases; (iii) Mendelian randomisation studies of causal relevance of traits for major diseases; (iv) Phenome-wide association studies of functional variants to aid drug development; (v) Comprehensive assessment of the health effects of environmental exposures (eg, ambient and household air pollution, ambient temperature, and built environment) on major CVD and non-CVD. The research priority will be given to those that are considered to be novel and to have major public health impact.
CKB is a global resource with huge potential to improve our understanding of disease aetiology, risk prediction and development of new therapies. It will also complement other large prospective studies (eg, UK Biobank) enabling investigations into a different range of genetic and other exposures that may be rare or absent in Western populations.
Organisations
- University of Oxford (Lead Research Organisation)
- Olink AB (Collaboration)
- University of Colorado Boulder (Collaboration)
- Novo Nordisk (Collaboration)
- Nightingale Health Ltd. (Collaboration)
- University of Hong Kong (Collaboration)
- German Cancer Research Center (Collaboration)
- ReproGen Consortium (Collaboration)
- Global Lipids Genetic Consortium (GLGC) (Collaboration)
- Fudan University (Collaboration)
- University of Bristol (Collaboration)
- University College London (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- McGill University (Collaboration)
- Social Science Genetics Association Consortium (Collaboration)
- University of Kuopio (Collaboration)
- University of North Carolina at Chapel Hill (Collaboration)
- Peking University (Collaboration)
- Beijing Genomics Institute (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Bayer (Collaboration)
- Chinese Academy of Sciences (Collaboration)
- SomaLogic (Collaboration)
- International Agency for Research on Cancer (IARC) (Collaboration)
Publications
Abhari RE
(2022)
External validation of models for predicting risk of colorectal cancer using the China Kadoorie Biobank.
in BMC medicine
Agbor VN
(2022)
Resting heart rate and risk of left and right heart failure in 0.5 million Chinese adults.
in Open heart
Arnold M
(2019)
Carotid Intima-Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass.
in Journal of the American Heart Association
Bakker MK
(2020)
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
in Nature genetics
Bennett DA
(2023)
MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
in International journal of epidemiology
Bennett DA
(2019)
Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults.
in BMJ open diabetes research & care
Bovijn J
(2020)
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
in Science Translational Medicine
Bovijn J
(2021)
Response to comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics".
in Science translational medicine
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MC_UU_00017/1 | 31/03/2019 | 31/03/2024 | £5,782,000 | ||
MC_UU_00017/2 | Transfer | MC_UU_00017/1 | 31/03/2019 | 31/03/2024 | £2,644,000 |
MC_UU_00017/3 | Transfer | MC_UU_00017/2 | 31/03/2019 | 31/03/2024 | £3,269,000 |
MC_UU_00017/4 | Transfer | MC_UU_00017/3 | 31/03/2019 | 31/03/2024 | £1,831,000 |
MC_UU_00017/5 | Transfer | MC_UU_00017/4 | 31/03/2019 | 31/03/2024 | £2,183,000 |
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Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2018 |
End | 12/2018 |
Description | Improving cancer prevention, risk-stratification, and detection using large-scale prospective studies in diverse populations |
Amount | £10,521,580 (GBP) |
Funding ID | C16077/A29186 |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2025 |
Description | The evaluation of effective healthcare delivery in China using electronic medical records for 10 years in 0.5M participants in the China Kadoorie Biobank |
Amount | £95,184 (GBP) |
Funding ID | 208126/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2017 |
End | 10/2021 |
Description | Visiting Research Fellowship Programme for the China Kadoorie Biobank |
Amount | £50,800 (GBP) |
Organisation | Sino-British Fellowship Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2017 |
End | 06/2022 |
Title | China Kadoorie Biobank - Research Database |
Description | China Kadoorie Biobank (CKB) is a blood-based prospective cohort study of 512,000 adults, recruited from 10 diverse areas across China (during 2004-08), with extensive data collection at baseline and subsequent resurveys and long-term storage of biological samples. These exposure and outcome data are complemented by separately funded genotyping (currently for 102,000 participants), whole genome sequencing, and conventional and multi-omics assays for nested case-control studies of specific diseases. |
Type Of Material | Database/Collection of data |
Year Produced | 2015 |
Provided To Others? | Yes |
Impact | Group staff and collaborating institution have published over 400 papers using the CKB database. Since opening CKB data up for open access in September 2015, over 800 researchers have registered on the CKB Data Access System. By February 2023 over 200 datasets had been approved and delivers to external collaborators and open access researchers. |
URL | https://www.ckbiobank.org/site/Data+Access |
Description | BDI |
Organisation | University of Oxford |
Department | Big Data Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analyses of CKB data conducted according to group protocols and summary results supplied. |
Collaborator Contribution | Development of Anlaysis protocol for GWAS for miscarriage. |
Impact | GWAS of miscarriage traits complete, results supplied, published in Nature Communications 2020, PMID: 33239672 |
Start Year | 2017 |
Description | Bayer - CKB Collaborative Research Programme |
Organisation | Bayer |
Country | Germany |
Sector | Private |
PI Contribution | Joint initiative to: Investigation of chymase gene variants in CKB; reformat plasma samples for future multiomics assays ; conduct analyses of pilot proteomics data; perform quality control and characterisation of ~80,000 putative loss-of-function, missense, or other functionally-significant variants; develop phenome-wide and bioinformatics analyses pipelines for future work. |
Collaborator Contribution | Selection of variants of interest w.r.t drug targets; review of ongoing progress; |
Impact | Initial results for Chymase investigation in CKB; selection of CKB samples for reformatting from freezer storage initiated. |
Start Year | 2019 |
Description | Beijing Genomics Institute |
Organisation | Beijing Genomics Institute |
Country | China |
Sector | Academic/University |
PI Contribution | In kind contributions to assay costs for various DNA projects. CKB are working with BGI on various research projects including DNA extraction and large-scale GWAS of 100,000 CKB samples. We are also collaborating with BGI's Research organisation on a Mitochondrial DNA Project. This Project involves a pilot project of high-coverage sequencing of the mitochondrial genomes of up to 100 parent-offspring trios (300 samples) from the China Kadoorie Biobank, followed by the main project of sequencing of 15,000 additional samples. These results can be used to assess the inheritance patterns of mitochondrial genomes, including the extent of heteroplasmy and paternal inheritance. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and are awaiting signature. Also conducting whole-genome sequencing of 10,000 samples from the China Kadoorie Biobank. The results of this project can be used to construct sequencing reference panels for imputation of genetic variants in individuals of Chinese ancestry, to assess the quality of genome-wide genotyping data, to investigate human population diversity, both within China and globally, and to identify novel genetic variants of potential relevance to human disease. Assisting with a Replication of BMI and height associations from low-coverage NGS association analyses. Framework agreements for the above projects and future research collaborations ( eg on methylation, microbiome DNA) have been agreed and being finalised |
Collaborator Contribution | BGI are providing the facilities and technical infrastructure for the conduct of genomic assays including data handling and shared analysis |
Impact | Large scale GWAS of 100,000 CKB samples complete data available for analysis. Lookup of GWAS association for ~1900 SNPs provided. Manuscript published in Cell for BMI and height GWAS Whole Genome Sequencing of 10,000k CKB Sample underway. |
Start Year | 2015 |
Description | CARDIOGRAMplusC4D |
Organisation | University of Oxford |
Department | Medical Sciences Division |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of GWAS Summary Statistics |
Collaborator Contribution | GWAS of myocardial infarction |
Impact | Data Shared Analysis in progress. |
Start Year | 2021 |
Description | Cambridge Cardiology |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Metaanalysis of NMR metabolomics GWAS |
Collaborator Contribution | Metaanalysis of NMR metabolomics GWAS |
Impact | NMR metabolomics GWAS complete, data supplied |
Start Year | 2019 |
Description | Chinese Academy of Sciences: Health Effects of fatty acids and irons |
Organisation | Chinese Academy of Sciences |
Department | Institute for Nutritional Sciences |
Country | China |
Sector | Learned Society |
PI Contribution | Established a large research project on dietary/environmental determinants and health effects of fatty acids and ions, based on CKB. This project has received major funding support from Chinese Academy of Sciences' Innovation fund to measure a whole range of fatty acid profile in erythrocyte membrane (n=10,000), ionomic profile in urine samples, as well as Hb1Ac among 25,000 resurvey participants. |
Collaborator Contribution | SIBS will conduct assays on samples from the China Kadoorie Biobank (CKB), including 25,000 urine and 25,000 blood red cell samples collected at the second resurvey. Red cell samples will be reformatted, and fatty acids (30 in total) assays will be conducted among the first 10,000 samples and HbA1c assays will be conducted among the total of 25,000 samples. Urine samples will be reformatted and ionomic (29 in total) and creatinine assays will be conducted. |
Impact | sample datasets being generated |
Start Year | 2016 |
Description | Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes |
Organisation | German Cancer Research Center |
Country | Germany |
Sector | Academic/University |
PI Contribution | Guidance and collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Collaborator Contribution | Collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Impact | Project funded by CRUK, Serology data generated and shared, Joint analyses ongoing. |
Start Year | 2017 |
Description | Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes |
Organisation | International Agency for Research on Cancer (IARC) |
Country | France |
Sector | Academic/University |
PI Contribution | Guidance and collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Collaborator Contribution | Collaborative development of research project "Comprehensive assessment of H. pylori antigens and other infectious pathogens in the aetiology of gastric and oesophageal cancer subtypes" |
Impact | Project funded by CRUK, Serology data generated and shared, Joint analyses ongoing. |
Start Year | 2017 |
Description | Developing a multiplex serology panel to detect and quantify Epstein-Barr virus infection |
Organisation | German Cancer Research Center |
Department | Division of Chronic Inflammation and Cancer Neuenheimer Feld 242, 69120 Heidelberg |
Country | Germany |
Sector | Academic/University |
PI Contribution | Lead the development of the research proposal based on the China Kadoorie Biobank cohort. Team is proivding epidemiological, access to prospective data and samples. (Case and cohort) |
Collaborator Contribution | DKFZ will lead the development of a Luminex-based EBV-Monoplex panel capable of quantifying the amounts of EBV biomarkers recently be identified as best predicting nasopharyngeal carcinoma risk by proteome array. |
Impact | Work in progress |
Start Year | 2019 |
Description | Fudan University: The associations of air pollution and ambient temperature exposure with omics biomarkers and mortality and incidence of major chronic diseases |
Organisation | Fudan University |
Country | China |
Sector | Academic/University |
PI Contribution | Joint development of a project on household and ambient air pollution (HAP/AAP) and temperature variations. will investigate the associations of HAP/AAP and temperature variations with a wide range of biomarkers from proteomics, metabolomics, and blood biochemistry assays. Furthermore, we will assess the potential mediation roles of the above biomarkers between the association of HAP/AAP and temperature with mortality and incidence disease outcomes. Contribution methodological development and access to CKB Data. |
Collaborator Contribution | Joint development of a project on household and ambient air pollution (HAP/AAP) and temperature variations. will investigate the associations of HAP/AAP and temperature variations with a wide range of biomarkers from proteomics, metabolomics, and blood biochemistry assays. Furthermore, we will assess the potential mediation roles of the above biomarkers between the association of HAP/AAP and temperature with mortality and incidence disease outcomes. Contribution methodological development and access to local environmental exposure datasets . . |
Impact | Publications being drafted. |
Start Year | 2023 |
Description | GLGC |
Organisation | Global Lipids Genetic Consortium (GLGC) |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | GWAS Data for ~18k subjects supplied to assist various meta analyses being conducted by this group. |
Collaborator Contribution | Large meta-analysis of TC, LDL-c, HDL-c, TG |
Impact | Metaanalysis complete, first manuscript to be submitted soon |
Start Year | 2017 |
Description | GWAS & Sequencing Consortium of Alcohol and Nicotine |
Organisation | University of Colorado |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS of smoking, alcohol, U Colorado, for the GENESCAN consortium |
Collaborator Contribution | GWAS results supplied. Metanalysis ongoing |
Impact | Summary statistics supplied, paper in preparation |
Start Year | 2018 |
Description | Investigation of proteomics in the China Kadoorie Biobank. |
Organisation | Novo Nordisk |
Country | Denmark |
Sector | Private |
PI Contribution | 1) To generate proteomic data covering 384 proteins, using the OLINK Explore 384 Cardiometabolic assay, in 2000 MI cases and 2000 population-based controls; 2) To investigate the genetic architecture of a panel of 384 proteins through GWAS.; 2) To undertake PheWAS of particular genetic variants for specific proteins with lifestyle factors, quantitative traits and disease outcomes. |
Collaborator Contribution | Contributions to funding for the project and provision of technical support and advice to CKB regarding any drug targets under investigation. and input on the statistical analysis plan and support for the GWAS of the proteins |
Impact | Proteomics data generated using the Olink Explore 1536 Platform |
Start Year | 2021 |
Description | McGill University |
Organisation | McGill University |
Department | Genetic Epidemiology Richards Lab |
Country | Canada |
Sector | Academic/University |
PI Contribution | Validation of genetic risk score for bone mineral density |
Collaborator Contribution | List of variants and weights supplied. |
Impact | Association results from up to 102K individuals for a BMD risk score with BMD and endpoints, published in Genome Medicine 2021, PMID: 33536041 |
Start Year | 2018 |
Description | Movement, Diabetes and CVD - Hong Kong |
Organisation | University of Hong Kong |
Country | Hong Kong |
Sector | Academic/University |
PI Contribution | Provision of data and analytical expertise on the folowing project "Replacing sedentary leisure time with alternative movement behaviours in 0.5 million Chinese adults: associations with incident type 2 diabetes and cardiovascular disease " |
Collaborator Contribution | Confuting the majority of the statistical analyses and provision and adoption of methodological framework for the project. |
Impact | Publications in preparation for submission. |
Start Year | 2023 |
Description | Nightingale Health, Finland |
Organisation | Nightingale Health Ltd. |
Country | Finland |
Sector | Private |
PI Contribution | Metaanalysis of SNPs and gene-specific GRSs with lipid/NMR data. Results sent for 13 SNPs, 3 GRSs, 228 traits, up to 17k samples. |
Collaborator Contribution | academic partnership |
Impact | Paper published in Circulation |
Start Year | 2018 |
Description | Novo Nordisk - Oxford : Fellowship |
Organisation | University of Oxford |
Department | Novo Nordisk – Oxford Fellowship Programme |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Support for a 3-year post doctoral fellowship investigating "Genomic approaches to improve understanding of T2D molecular phenotypes, mechanisms, and development of major complications in diverse populations" CKB team will be providing access to CKB data and expert supervision and guidance. |
Collaborator Contribution | Novo Nordiask Fellowship scheme will provide financial support alongside expert supervision and training from their research and development teams. |
Impact | None to date ( early stages) |
Start Year | 2022 |
Description | OLINK Proteomics Expansion Analysis |
Organisation | Olink AB |
Country | Sweden |
Sector | Private |
PI Contribution | Provision of CKB samples for analysis and permission to agreed usage of a subset of the resulting data and additional pre-existing CKB study data (Questionnaire, Physical Measurement and Olink data). CKB will use the resulting data to investigate the associations of novel proteomic markers with risk of IHD (and other diseases) and to identify novel biomarkers for risk prediction and potentially modifiable targets for treatment and prevention of IHD; |
Collaborator Contribution | The multiplex biomarker panel, Olink® EXPLORE Expansion Analysis (1536), is to be used to measure 1472 high-quality assays for proteins important for inflammation or related biological processes.. OLINK agreed to provide these services free of charge contingent on the agreed usage of a subset of the resulting data and additional pre-existing CKB study data (Questionnaire, Physical Measurement and Olink data). |
Impact | Data has been delivered to CKB and initial publication have been drafted for submission to peer reviewed journals. |
Start Year | 2022 |
Description | Peking University PKU |
Organisation | Peking University |
Country | China |
Sector | Academic/University |
PI Contribution | Replication of fingerprint GWAS. Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided. Results of GWAS provided for metaanalysis. |
Collaborator Contribution | academic partnership |
Impact | Lookup of GWAS association for 118 SNPs with 20 fingerprint features provided, full GWAS provided for metaanalysis, paper in preparation |
Start Year | 2018 |
Description | Pilot study for evaluation of polygenic risk scores in Chinese adults |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | University of Oxford parties will implement the analyses in CKB and assess the associations of six PGS scores with six CVD risk factors and six disease outcomes. The analyses will also assess the discrimination and calibration of the PGS scores for each trait. At least for total CVD, total stroke and total IHD, the analyses will compare discrimination and calibration of established non-genetic scores with PGS scores |
Collaborator Contribution | Cambridge will provide to Oxford parties PGS scores for six CVD risk factors and six CVD outcomes with appropriate instructions to complete the scores for the six continuous and six dichotomous traits in CKB. Tasks: • To provide genetic instruments for six quantitative traits in CKB and instructions ion their use • To provide Genetic instruments for six disease outcomes in CKB and instructions ion their use |
Impact | Initial datasets shared |
Start Year | 2022 |
Description | Reprogen |
Organisation | ReproGen Consortium |
Country | Global |
Sector | Academic/University |
PI Contribution | Conducting GWAS of reproductive traits. |
Collaborator Contribution | GWAS analyses complete. Currently doing lookup of existing (known) hits, and various heritability analyses. In discussion about future joint analyses/papers |
Impact | Association results from 31177 individuals for 247 variants supplied, revised manuscript submitted to Nature |
Start Year | 2017 |
Description | Social Science Genetics Association Consortium |
Organisation | Social Science Genetics Association Consortium |
Country | Global |
Sector | Charity/Non Profit |
PI Contribution | GWAS of socioeconomic traits, USC, USA, for the SSGAC consortium |
Collaborator Contribution | GWAS results supplied for ~10 different traits. |
Impact | ~12 sets of summary stats supplied. Manuscript to be submitted soon |
Start Year | 2018 |
Description | Somalogic Proteomics |
Organisation | SomaLogic |
Country | United States |
Sector | Private |
PI Contribution | Access to CKB samples to SomaLogic's SOMAscan® Assay. Evaluation of the performance of the following SomaSignal tests (SSTs) for prediction of cardiovascular risk; ii. Evaluate the SSTs for metabolic health compared to relevant clinical measures in the CKB. Investigate proteomic associations with CV risk and cardiometabolic health in the Chinese population. Evaluate the performance of SomaLogic Data compared to data generated using a differing proteomic platform in the Samples |
Collaborator Contribution | SomaLogic will evaluate the Samples using its SOMAscan Assay (including the Restricted SOMAmer Content) utilizing reagents and protocols developed and standardized by SomaLogic. SomaLogic will advise Oxford on issues related to data processing, normalization, transformation, and QC check; Somalogic and Oxford will will collaborate on submission of the Research Results to a peer-reviewed publication and plan follow-on studies and/or additional analyses |
Impact | Data has been generated by Somalogic and delivered to Oxford for analysis. |
Start Year | 2022 |
Description | UCL - Lipid traits - KK |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Signals of natural selection for lipid traits |
Collaborator Contribution | Signals of natural selection for lipid traits |
Impact | Summary stats provided, data access provided to KK as visiting researcher, paper published in Nature Communications 2019, PMID: 31551420 |
Start Year | 2019 |
Description | UCL - Lipid traits - KK |
Organisation | University College London |
Department | Division of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Signals of natural selection for lipid traits |
Collaborator Contribution | Signals of natural selection for lipid traits |
Impact | Summary stats provided, data access provided to KK as visiting researcher, paper published in Nature Communications 2019, PMID: 31551420 |
Start Year | 2019 |
Description | UNC School of Medicine - Psychiatric Genomes Consortium |
Organisation | University of North Carolina at Chapel Hill |
Country | United States |
Sector | Academic/University |
PI Contribution | GWAS of various psychiatric and related traits, |
Collaborator Contribution | Analysis plan received for GWAS of Major Depression and for Depressive Symptoms. GWAS completed, summary statistics supplied. |
Impact | Summary stats supplied, manuscript submitted to Nature Genetics, data access provided for supplementary analyses to KK as visitiing researcher from UCL under the Psychiatric Genomes Consortium |
Start Year | 2018 |
Description | University of Bristol |
Organisation | University of Bristol |
Department | MRC Integrative Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Three projects: 1) GWAS of alcohol-related flushing and flushing 2) Within families GWAS of multiple traits 3) Mendelian randomisation of education |
Collaborator Contribution | Visiting researcher from Bristol working within CKB. |
Impact | Access to data for all three projects provided to visiting researcher. Analysese ongoing, Within families GWAS analyses completed for priority traits, manuscript submitted to Nature Genetics |
Start Year | 2018 |
Description | University of Nottingham Malaysia/Cancer Research Malaysia |
Organisation | University of Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of Risk score association results for Meta analysis |
Collaborator Contribution | Leadership of project and aggregations of other data sources |
Impact | Association results provided for 4 risk scores. Manuscript submitted to Nature Communications |
Start Year | 2020 |
Description | Urine NMR Metabolomics |
Organisation | University of Kuopio |
Country | Finland |
Sector | Academic/University |
PI Contribution | Provision of 25,000 CKB Urine samples and associated participant data for quantification of metabolites, |
Collaborator Contribution | Kuopio will employ a NMR-spectroscopy protocol that has been developed, optimized and validated by them to measure up to 50 biomarkers in all ~25,000 samples. Kuopio will quantify metabolite peaks and generate metabolite concentrations. Data will be available in absolute concentrations (?mol/L), as well as referenced to creatinine concentration. Data resultsin all ~25,000 samples will be shared with Oxford. As additional information for other metabolites becomes available using the NMR spectra, these will be provided to Oxford. |
Impact | Samples shipped, analyses being conducted |
Start Year | 2020 |
Description | ?????? An online public engagement project in China about processed meat |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | While researching the health impacts of meat, we noticed that the definition of processed meat is partly unclear. With the ?????? online survey we wanted to find out more about the public's understanding of processed meat, in order to feed this back into our work and improve how we communicate our research findings with the public. We were also interested in understanding public's attitude towards reduction of meat consumption. Our online survey was in the Chinese language and it ran for five weeks, reaching 341 people from China. This survey was based on the 'Don't go bacon my heart' survey, which was launched in 2020 and reached English speaking people (https://www.leap.ox.ac.uk/article/dont-go-bacon-my-heart-what-do-we-mean-when-we-talk-about-processed-meat). Currently, the results of the?????? online survey are being analysed and they will be published soon on the CKB and LEAP websites. Audience: Adults living in China Researchers: Maria Kakkoura and Huaidong Du (CKB-CTSU), Keren Papier and Anika Knuppel (CEU), Liu Xin and Yafang He (Xi'an Jiaotong University). Duration: 21 December 2021 - 31 January 2022 Location: Online survey |
Year(s) Of Engagement Activity | 2021,2022 |
Description | Alcohol Phewas paper engagement |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Becky Im responded to queries from press on the Nat Med 2023 CKB alcohol PheWAS paper (Fox News in June 2023; Norway's newspaper VG in September 2023); She also co-wrote (with Iona Millwood) a blog with Iona Millwood on the CKB alcohol PheWAS paper on the Institute of Alcohol Studies website (June 2023). |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ias.org.uk/2023/06/13/unveiling-the-hidden-health-hazards-of-alcohol-use/ |
Description | Alcohol and CVD paper engangement activities |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Media coverage of publication of alcohol and CVD, including BBC TV and radio interviews, and a press conference for national newspapers, April 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | BBC World Service = Science In Action |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview on the BBC World Service programme Science in Action - Professor Zhengming Chen explained how the seed of an idea grew into one of the world's largest prospective studies. "In 2004, about a year after the first human genome was sequenced, the China Kadoorie Biobank received funding to start collecting blood samples from over half a million people in ten regions of China. Samples were put into long-term storage and now, nearly 20 years later, the technology is available to analyse tiny samples of blood for thousands of proteins and metabolites. The millions of stored blood samples are bar-coded and linked to other data collected from the study participants including genetic data and information on lifestyle factors and health conditions. Professor Chen and colleagues from the NDPH Wolfson Laboratories described how this unique resource provides opportunities for endless research. Professor Chen predicted that over the next five to ten years the CKB will generate a huge amount of information that will enable a better understanding of the prevention and treatment of many diseases." (starts:11.40 ends:18.53) |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.bbc.co.uk/programmes/w3ct369l |
Description | Clinical Specialist workshop, China |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | PInvited presentation at the 6th annual joint conference of Chinese Stroke Association & Tiantan International Stroke Conference 2020 (CSA&TISC 2020) - Silent Stroke in Chinese Adults: Progress and Prognosis |
Year(s) Of Engagement Activity | 2020 |
Description | Festival of Genomics and Biodata |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on "Using human genetics to improve the odds of drug development"" |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.festivalofgenomics.com/ |
Description | Human Proteome and Public Health Symposium (Researchers and Industry Partners) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 200+ people attended this one-day symposium which brought together academic researchers, biobank managers and a range of proteomics industry partners to discuss emerging analysis results and assay platforms developments. The event helped |
Year(s) Of Engagement Activity | 2023 |
Description | Interview for national and International News |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | responded to over a dozen separate requests for media interviews (inc Radio,TV (ITV) and Print ) for an expert reflection of the COVID Epidemic in China (for a more global audience). |
Year(s) Of Engagement Activity | 2022,2023 |
Description | Interviews for national and International News |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | responseded to approximately 20 separate requests for media interviews (inc Radio,TV and Print ) for an expert reflection of the COVID Epidemic in Europe (for Chinese media) and also on the epidemiology of the COVID 19 within China (for a more global audience). |
Year(s) Of Engagement Activity | 2021,2022 |
Description | Late night: Consumed |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | A stall activity was carried out within the 'Late night: Consumed' event with the title 'Extra Extra: Meat is back in the news'. The 'Late night: Consumed' event was part of the Special exhibition 'Meat the future' at the Oxford Natural History Museum (https://oumnh.web.ox.ac.uk/meat-the-future). The aims of the activity were to: -Get a sense of how people react to the news headlines of the diet and health research (nutritional epidemiology) and particularly on meat consumption and disease risk. -Communicate to the public the challenges we face in our research of nutritional epidemiology and how they can 'survive' this kind of headlines. In order to spark the conversation with the public on this topic, we had copies of various real headline news on meat and health and a crossword with words relevant to epidemiology and meat consumption. Audience: Adults Researchers: Maria Kakkoura (CKB-CTSU) and Keren Papier (CEU) |
Year(s) Of Engagement Activity | 2021 |
URL | https://oumnh.web.ox.ac.uk/event/late-night-consumed |
Description | Meat Your Persona |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Meat Your Persona (https://meatyourpersona.com/) was a travelling exhibition around the UK during the summer of 2021 exploring how the production and consumption of meat affects our health and our environment. It was based on the research findings from the LEAP project at the University of Oxford. The activity aimed to get a sense of how much the public understands the connection between meat and climate change and how it incentivises them to change or not change their dietary habits. The public had an interactive quiz to complete, in order to discover which of the six meat personas they are. With this quiz, they could learn about aspects of their eating behaviour and became aware of the impacts of meat eating. The quiz resulted in the LEAP researchers having a dialogue with the public about their meat consumption choices and gave insight about public's informed meat consumption choices. Maria Kakkoura (from the CKB Group) attended one of the days of the exhibition in Glasgow. |
Year(s) Of Engagement Activity | 2021 |
URL | https://meatyourpersona.com/ |
Description | Media Interview |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Interview for and article on Exposure to solid fuel for cooking linked to lung cancer mortality risk |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.healio.com/news/pulmonology/20221201/exposure-to-solid-fuel-for-cooking-linked-to-lung-c... |
Description | Media Interviews on Air pollution |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | interview with That's TV South (UK) on study findings on the impact of household air pollution on eye disease - for a news programme; interview with NTV Broadcasting Company (Russia) on study findings on the impact of household air pollution on eye disease - for a popular science education programme |
Year(s) Of Engagement Activity | 2021 |
Description | Media engagement COVID-19 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Prof Chen has provided numerous interviews and opinion pieces in relation to the COVID-19 Pandemic throughout the last year. His expertise as an world leading epidemiologist and knowledge of China has been in high demand. These covered the outbreak in China and the first wave in Europe. The second wave and impact of vaccination programmes. Media channels included BBC news, Chinese and Hong Kong TV, National newspapers and Radio stations, Nature editorials. |
Year(s) Of Engagement Activity | 2020 |
Description | PPIE workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Derrick bennett co-led a workshop @ University of Leicester on "PPIE for statistical methodology research" February 2024 |
Year(s) Of Engagement Activity | 2023 |
Description | Pharmacogenetics: New Frontiers Practitioner Presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A one hour online session targeted towards Egyptian Pharmacists, outlining the latest advances in the field of pharmacogenomics and the current low-hanging fruits for implementation.(Free session within a training module, accredited by Egyptian Association of Continuing Medical Education) |
Year(s) Of Engagement Activity | 2023 |
Description | Press Release - Dairy Products and Cancer |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Press release developed with BMC Medicine journal to share results of the first major study to investigate dairy consumption and cancer risk in Chinese adults ( this found that greater intake was associated with higher risks of liver cancer and female breast cancer.) |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.ckbiobank.org/news/dairy-products-linked-to-increased-risk-of-cancer |
Description | Press release - optimum blood pressure for Chinese Adults |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Press Release to promote the funding of a research paper published in "Hypertension" the paper showed new evidence on optimum blood pressure levels for prevention of cardiovascular diseases in Chinese adults. it demonstrated that a person could still be at risk of both stroke and coronary heart disease even if their systolic blood pressure (pressure in their arteries when their heart beats) is well below the threshold of 140 mmHg, which is conventionally used to determine whether or not a person needs to start blood pressure-lowering medication. |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ckbiobank.org/news/new-evidence-on-optimum-blood-pressure-levels-for-prevention-of-cardi... |
Description | Press release - overall and cause-specific death rates in China during COVID |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Series of interviews in National and international print and broadcast media following press release of a paper produced in collaboration with the Chinese Center for Disease Control and Prevention (China CDC. This examined the change in overall and cause-specific death rates during the three months of the COVID-19 outbreak in early 2020. Published in the BMJ, the report found that overall deaths did not increase in China outside Wuhan city during the first three months of the COVID-19 outbreak, with the small increase in deaths from COVID-19 more than offset by fewer deaths from other causes. Interview provided to Reuters News agency which was widely distributed. |
Year(s) Of Engagement Activity | 2020 |
Description | Research paper press releases x 7 Covering Tobacco Control; Alcohol Consumption and Disease Risk; Blood Proteins and Heart Disease Drug Targets; Folic Acid and Stroke; Blood Proteins and Obesity Treatment Targets; Genotyping and Populations Characteristics in CKB |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Seven separate press releases prepared and circulated via central Oxford Press office, Journal Press Offices , OxPop and CKB Websites during 2023 covering a range of topics to accompany major publication outputs |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ckbiobank.org/news-1 |
Description | School Visit - Work experience training programme |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | To provide a broad introduction to the work of the Nuffield Department of Population Health, covering: Prospective Cohort Studies and Epidemiology ( CKB Half-Day) Clinical Trials; Statistics; Research Ethics and Laboratory assay provision. |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.ndph.ox.ac.uk/about/work-experience |
Description | Smoking Phewas Study |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Press release jointly produced with Lancet Public Health representatives in China to disseminate a paper on the effects of smoking on the Chinese population. "This was the first paper to systematically assess the impact of smoking on an extensive range of diseases within the same population. The researchers used data from the China Kadoorie Biobank to comprehensively assess the health effects of tobacco smoking on death and hospitalisation from a range of diseases and to examine the benefit of smoking cessation. " Smoking was found to increase the risks of 56 diseases in Chinese Adults. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.ckbiobank.org/news/smoking-increases-the-risks-of-56-diseases-in-chinese-adults |
Description | Super Science Saturday: People & Planet event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | A stall activity was carried out within the family science fair 'Super Science Saturday: People & Planet'' event with the title 'The fun world of data'. This event was part of the Special exhibition 'Meat the future' at the Oxford Natural History Museum (https://oumnh.web.ox.ac.uk/meat-the-future). The main messages that we aimed to communicate to the families when visiting our stall activity were the below: • Almost anything can be described as data (i.e. most things can give us information) • There are different types of data, and they can be used in different ways • How scientists use dietary data collected from different populations to better understand how diet affects health During the activity, we used Lego bricks and stickers that represented different types of data to communicate how we use data in our research, which proved very popular with young children in particular. This gave us the opportunity to chat with them and gain an insight into the messages they took home from the event. Audience: Families and children Researchers: Maria Kakkoura (CKB-CTSU) and Keren Papier (CEU) Date: 27th November 2021 Location: Oxford Natural History Museum, Oxford |
Year(s) Of Engagement Activity | 2021 |
URL | https://oumnh.web.ox.ac.uk/event/super-science-saturday-people-planet |
Description | Talk at Laurus Ryecroft School |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | "A career as a physician scientist, pharmaceutical physician and epidemiologist" |
Year(s) Of Engagement Activity | 2020 |
Description | UK Parliament POST note on "Diet, nutrition and cancer " |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Contribution to the recent UK Parliament POSTnote on "Diet, nutrition and cancer" offering views and evidence on alcohol and cancer via an interview (20th Feb 2024). This work aims to summarise the existing evidence, research methods, public health trends and interventions surrounding diet nutrition and cancer. |
Year(s) Of Engagement Activity | 2024 |
URL | https://post.parliament.uk/approved-work-diet-nutrition-and-cancer/ |
Description | interview with Australia Broadcast Company (Peter / Kahung Chan) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview with Australia Broadcast Company on COVID situation in Hong Kong |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.abc.net.au/news/2022-02-18/hong-kong-covid-zero-no-match-for-omicron/100838410 |