Standards for determining the vascular contribution to neurodegeneration

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Molecular. Genetics & Pop Health

Abstract

There are many causes of cognitive decline and dementia with ageing. The common causes tend to overlap, aren't well understood and have a similar appearance on imaging. Many of the imaging features are not well-defined. We are establishing a worldwide group of experts to create a common language for describing the imaging features and conducting imaging research in order to define the role of blood vessels in dementia.

Technical Summary

Neurodegeneration during ageing is commonly associated with neuroimaging features of small vessel disease (SVD): lacunes, leukoaraiosis, enlarged perivascular spaces, microbleeds, brain atrophy. These exacerbate, and are closely interrelated with, cognitive impairment, disability and dementia arising from neurodegeneration. The terminology and definitions used to describe these common imaging features vary widely, impairing clinical characterisation and subject phenotyping. This is a major barrier to progress in determining the full pathophysiology of neurodegeneration plus the contribution that SVD makes to the clinical expression of common neurodegenerative diseases and to their cause. The COEN Initiative represents, par excellence, a timely opportunity to establish a collaborative expert network to agree standard definitions and terminologies for SVD on neuroimaging, provide easy-to-access exemplars, suggested image acquisition and analysis protocols and standards for reporting of studies to optimise future research. The investigators bring complementary multidisciplinary expertise on clinical imaging of neurodegeneration from cerebrovascular, Alzheimer's disease, and ageing perspectives. UK, German and Canadian COEN experts plus external collaborators will undertake two workshops, prepare and test agreed exemplars and advisory materials. The proposed work is not being undertaken elsewhere yet is essential for improved phenotyping to advance future epidemiology, genetic, pathology research and clinical trials in the commonest neurodegenerative disorders.

Planned Impact

Intellectual property: The project is unlikely to generate intellectual property, although the initiative could lead to intellectual property in the future. However this would require more funding and would be covered under specific agreements. In the unlikely event that any intellectual property is generated, all host institutions have technology transfer offices that are able to manage such work. In the case of Edinburgh, there is already a substantial investment from MRC in technology transfer activities and these have been highly successful.
Dissemination: Plans for dissemination include peer-review journal publications, materials downloadable from partner and key society websites, and specific symposia in which the outputs from the workshops can be fed back to the community that is most critically interested at international conference symposia that will be taking place around the end of the project. The major peer-review publication will be targeted at, for example, Lancet Neurology. Materials such as an agreed set of descriptors of neuroimaging features of SVD, qualitative and quantitative rating tools and guidance on their use, imaging examples of SVD, standards for image acquisition, standards for scientific reporting of methods, analysis and results of studies on age-related SVD and neurodegeneration, bibliographies of relevant papers, datasets, analysis software and teaching materials and advisory core standards for data collection in future studies of neurodegeneration and SVD can all be made available on websites, in addition to publication in journals where appropriate. International conferences taking place around the end of the project period include the International Society for Vascular and Cognitive Behavioural Disorders (VasCog), taking place in Toronto, June 2013. Local Organising Committee lead S Black has already suggested a symposium to describe and discuss the project outputs should take place within the VasCog 2013 programme. We will also
propose a symposium on SVD at the European Stroke Conference May 2013, likely just before the end of the project, but timely for final feedback. We will endeavour to have guidance on standards for scientific reporting of methods, analysis and results of studies on age-related SVD and neurodegeneration in a form that can easily be incorporated into relevant journal instructions for authors and on the Equator website (http://www.equator-network.org/).

Organisations

Publications

10 25 50

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De Guio F (2016) Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

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Dichgans, M New Definitions and New Standards (invited talk) in 9th World Stroke Conference, 22-25 October 2014, Istanbul, Turkey

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Dichgans, Martin Why do we need standards for vascular lesions on neuroimaging? Setting the scence in European Stroke Conference, 29th May 2013, London.

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Duering, Marco (2013) Standards For Reporting Vascular Changes On Neuroimaging (STRIVE) - outcomes of the COEN Initiative in 8th International Congress on Vascular Dementia & 1st Cognitive Impairment European Meeting, 19th October, Athens

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Gattringer T (2015) Morphological MRI characteristics of recent small subcortical infarcts. in International journal of stroke : official journal of the International Stroke Society

 
Description EC Horizon 2020: Small vessel diseases in a mechanistic perspective: targets for intervention affected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs@Target)
Amount € 6,000,000 (EUR)
Funding ID 666881 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2016 
End 12/2020
 
Description EPSRC Research Grant
Amount £1,100,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 05/2018
 
Description EU Joint Programme - Neurodegenerative Disease Research
Amount € 47,416 (EUR)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 10/2014 
End 03/2015
 
Description Fondation Leducq Transatlantic Networks of Excellence Program
Amount $6,000,000 (USD)
Funding ID 16 CVD 05 
Organisation The Leducq Foundation 
Sector Charity/Non Profit
Country France
Start 10/2016 
End 09/2021
 
Description Innovate-UK
Amount £1,048,661 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)"
Amount € 49,855 (EUR)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2017
 
Description Row Fogo Centre for Research into Ageing and The Brain
Amount £313,717 (GBP)
Organisation The Row Fogo Charitable Trust 
Start 09/2018 
End 08/2021
 
Description SINAPSE PEER
Amount £6,000 (GBP)
Organisation Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) 
Sector Public
Country United Kingdom
Start 04/2014 
End 06/2015
 
Description SINAPSE PEER
Amount £6,000 (GBP)
Organisation Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) 
Sector Public
Country United Kingdom
Start 04/2015 
End 09/2016
 
Description UK Dementia Research Initiative - "Small vessel diseases and vascular contributions to neurodegeneration and dementia"
Amount £1,499,996 (GBP)
Funding ID UKDRI-4002 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2022
 
Description COEN 
Organisation German Centre for Neurodegenerative Diseases
Department Institute for Stroke and Dementia Research
Country Germany 
Sector Academic/University 
PI Contribution Development of guidelines for contribution of imaging of small vessel disease.
Collaborator Contribution Development of guidelines for contribution of imaging of small vessel disease.
Impact 2 Lancet Neurology papers in 2013 (see publications) Accepted embedded symposiums in the International Stroke Conference (February 2013), European Stroke Conference (May 2013), VasCog (June 2013), and World Stroke Conference (October 2014) Invited lecture (M Dichgans) at 9th World Stroke Congress, Istanbul (see publications) EU Joint Programme - Neurodegenerative Disease Research grant awarded for "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration", €47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, M Dichgans, F Fazekas, R Schmidt, H Chabriat, C Cordonnier, E Jouvent, MMB Breteler, F Jessen, L Pantoni, GJ Biessels, F-E de Leeuw, MA Ikram, M Vernooij, RJ van Oostenbrugge, C Brayne, IJ Deary, JT O'Brien, PM Matthews, JM Starr, BC Stephan, DJ Werring, E Smith. Lancet Neurology editorial April 2012 (see publications) Methods to evaluate likely underlying mechanisms of SVD are being tested in collaboration between the Austrian Stroke Prevention Study (Fazekas, COEN expert, Gratz) and Edinburgh, including a) evaluation of brain mineral deposition and b) of embolic, atheromatous and intrinsic mechanisms of lacunar stroke in a population study. One paper submitted from collaboration with Fazekas group in Graz. (see publications) Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending. Collaboration around post-mortem imaging methods for examination of individual vascular features is proceeding between investigators in Lille (COEN expert Cordonnier) and Edinburgh. Neuropathologist (Catherine Humphries) started as Stroke Association Princess Margaret Research Fellow on neuroimaging and neuropathology in SVD, jointly supervised with Colin Smith. Chabriat and colleagues are planning a trial of interventions in a monogenic form of small vessel disease, CADASIL, with input from several COEN partners (Dichgans, Werring, Wardlaw, Benavente). The International Stroke Genetics Consortium has set up an imaging standards subgroup (which includes JM Wardlaw) to improve use of imaging in phenotyping for stroke and dementia gene discovery studies. A publication is accepted in Stroke. Munich collaborators working on various applications. EU Horizon 2020 outline submitted (Dichgans, van Oostenbrugge, Wardlaw. Three groups are working on improved methods for patient stratification and outcome assessment in randomised controlled trials of interventions to prevent progression of small vessel disease and vascular and non-vascular neurodegeneration (Benavente, Chabriat, Wardlaw). Further validation of the derived standard is currently being undertaken by Smith, Wardlaw and Dichgans with Smith leading, including testing the reporting checklist on randomly chosen relevant publications and refining the checklist, expected to report in early 2014. Abstract (E Smith) accepted for International Stoke Conference in February 2015. A multi-centre trial of interventions to prevent small vessel disease progression is being planned in the UK with advice from Benavente and Chabriat. Outline approved by BHF, full submission pending. Application for randomised clinical trial testing two promising agents in a short-term intermediary outcomes trial submitted to Alzheimer's Society. The investment is therefore leading directly to interventions which, if successful, should reduce the impact of the vascular contribution to neurodegeneration.
Start Year 2012
 
Description COEN 
Organisation Lille University Hospital
Department Department of Neurology
Country France 
Sector Hospitals 
PI Contribution Development of guidelines for contribution of imaging of small vessel disease.
Collaborator Contribution Development of guidelines for contribution of imaging of small vessel disease.
Impact 2 Lancet Neurology papers in 2013 (see publications) Accepted embedded symposiums in the International Stroke Conference (February 2013), European Stroke Conference (May 2013), VasCog (June 2013), and World Stroke Conference (October 2014) Invited lecture (M Dichgans) at 9th World Stroke Congress, Istanbul (see publications) EU Joint Programme - Neurodegenerative Disease Research grant awarded for "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration", €47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, M Dichgans, F Fazekas, R Schmidt, H Chabriat, C Cordonnier, E Jouvent, MMB Breteler, F Jessen, L Pantoni, GJ Biessels, F-E de Leeuw, MA Ikram, M Vernooij, RJ van Oostenbrugge, C Brayne, IJ Deary, JT O'Brien, PM Matthews, JM Starr, BC Stephan, DJ Werring, E Smith. Lancet Neurology editorial April 2012 (see publications) Methods to evaluate likely underlying mechanisms of SVD are being tested in collaboration between the Austrian Stroke Prevention Study (Fazekas, COEN expert, Gratz) and Edinburgh, including a) evaluation of brain mineral deposition and b) of embolic, atheromatous and intrinsic mechanisms of lacunar stroke in a population study. One paper submitted from collaboration with Fazekas group in Graz. (see publications) Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending. Collaboration around post-mortem imaging methods for examination of individual vascular features is proceeding between investigators in Lille (COEN expert Cordonnier) and Edinburgh. Neuropathologist (Catherine Humphries) started as Stroke Association Princess Margaret Research Fellow on neuroimaging and neuropathology in SVD, jointly supervised with Colin Smith. Chabriat and colleagues are planning a trial of interventions in a monogenic form of small vessel disease, CADASIL, with input from several COEN partners (Dichgans, Werring, Wardlaw, Benavente). The International Stroke Genetics Consortium has set up an imaging standards subgroup (which includes JM Wardlaw) to improve use of imaging in phenotyping for stroke and dementia gene discovery studies. A publication is accepted in Stroke. Munich collaborators working on various applications. EU Horizon 2020 outline submitted (Dichgans, van Oostenbrugge, Wardlaw. Three groups are working on improved methods for patient stratification and outcome assessment in randomised controlled trials of interventions to prevent progression of small vessel disease and vascular and non-vascular neurodegeneration (Benavente, Chabriat, Wardlaw). Further validation of the derived standard is currently being undertaken by Smith, Wardlaw and Dichgans with Smith leading, including testing the reporting checklist on randomly chosen relevant publications and refining the checklist, expected to report in early 2014. Abstract (E Smith) accepted for International Stoke Conference in February 2015. A multi-centre trial of interventions to prevent small vessel disease progression is being planned in the UK with advice from Benavente and Chabriat. Outline approved by BHF, full submission pending. Application for randomised clinical trial testing two promising agents in a short-term intermediary outcomes trial submitted to Alzheimer's Society. The investment is therefore leading directly to interventions which, if successful, should reduce the impact of the vascular contribution to neurodegeneration.
Start Year 2012
 
Description COEN 
Organisation Medical University of Graz
Department Department of Neurology
Country Austria 
Sector Academic/University 
PI Contribution Development of guidelines for contribution of imaging of small vessel disease.
Collaborator Contribution Development of guidelines for contribution of imaging of small vessel disease.
Impact 2 Lancet Neurology papers in 2013 (see publications) Accepted embedded symposiums in the International Stroke Conference (February 2013), European Stroke Conference (May 2013), VasCog (June 2013), and World Stroke Conference (October 2014) Invited lecture (M Dichgans) at 9th World Stroke Congress, Istanbul (see publications) EU Joint Programme - Neurodegenerative Disease Research grant awarded for "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration", €47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, M Dichgans, F Fazekas, R Schmidt, H Chabriat, C Cordonnier, E Jouvent, MMB Breteler, F Jessen, L Pantoni, GJ Biessels, F-E de Leeuw, MA Ikram, M Vernooij, RJ van Oostenbrugge, C Brayne, IJ Deary, JT O'Brien, PM Matthews, JM Starr, BC Stephan, DJ Werring, E Smith. Lancet Neurology editorial April 2012 (see publications) Methods to evaluate likely underlying mechanisms of SVD are being tested in collaboration between the Austrian Stroke Prevention Study (Fazekas, COEN expert, Gratz) and Edinburgh, including a) evaluation of brain mineral deposition and b) of embolic, atheromatous and intrinsic mechanisms of lacunar stroke in a population study. One paper submitted from collaboration with Fazekas group in Graz. (see publications) Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending. Collaboration around post-mortem imaging methods for examination of individual vascular features is proceeding between investigators in Lille (COEN expert Cordonnier) and Edinburgh. Neuropathologist (Catherine Humphries) started as Stroke Association Princess Margaret Research Fellow on neuroimaging and neuropathology in SVD, jointly supervised with Colin Smith. Chabriat and colleagues are planning a trial of interventions in a monogenic form of small vessel disease, CADASIL, with input from several COEN partners (Dichgans, Werring, Wardlaw, Benavente). The International Stroke Genetics Consortium has set up an imaging standards subgroup (which includes JM Wardlaw) to improve use of imaging in phenotyping for stroke and dementia gene discovery studies. A publication is accepted in Stroke. Munich collaborators working on various applications. EU Horizon 2020 outline submitted (Dichgans, van Oostenbrugge, Wardlaw. Three groups are working on improved methods for patient stratification and outcome assessment in randomised controlled trials of interventions to prevent progression of small vessel disease and vascular and non-vascular neurodegeneration (Benavente, Chabriat, Wardlaw). Further validation of the derived standard is currently being undertaken by Smith, Wardlaw and Dichgans with Smith leading, including testing the reporting checklist on randomly chosen relevant publications and refining the checklist, expected to report in early 2014. Abstract (E Smith) accepted for International Stoke Conference in February 2015. A multi-centre trial of interventions to prevent small vessel disease progression is being planned in the UK with advice from Benavente and Chabriat. Outline approved by BHF, full submission pending. Application for randomised clinical trial testing two promising agents in a short-term intermediary outcomes trial submitted to Alzheimer's Society. The investment is therefore leading directly to interventions which, if successful, should reduce the impact of the vascular contribution to neurodegeneration.
Start Year 2012
 
Description COEN 
Organisation University of Calgary
Department Department of Clinical Neurosciences
Country Canada 
Sector Academic/University 
PI Contribution Development of guidelines for contribution of imaging of small vessel disease.
Collaborator Contribution Development of guidelines for contribution of imaging of small vessel disease.
Impact 2 Lancet Neurology papers in 2013 (see publications) Accepted embedded symposiums in the International Stroke Conference (February 2013), European Stroke Conference (May 2013), VasCog (June 2013), and World Stroke Conference (October 2014) Invited lecture (M Dichgans) at 9th World Stroke Congress, Istanbul (see publications) EU Joint Programme - Neurodegenerative Disease Research grant awarded for "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration", €47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, M Dichgans, F Fazekas, R Schmidt, H Chabriat, C Cordonnier, E Jouvent, MMB Breteler, F Jessen, L Pantoni, GJ Biessels, F-E de Leeuw, MA Ikram, M Vernooij, RJ van Oostenbrugge, C Brayne, IJ Deary, JT O'Brien, PM Matthews, JM Starr, BC Stephan, DJ Werring, E Smith. Lancet Neurology editorial April 2012 (see publications) Methods to evaluate likely underlying mechanisms of SVD are being tested in collaboration between the Austrian Stroke Prevention Study (Fazekas, COEN expert, Gratz) and Edinburgh, including a) evaluation of brain mineral deposition and b) of embolic, atheromatous and intrinsic mechanisms of lacunar stroke in a population study. One paper submitted from collaboration with Fazekas group in Graz. (see publications) Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending. Collaboration around post-mortem imaging methods for examination of individual vascular features is proceeding between investigators in Lille (COEN expert Cordonnier) and Edinburgh. Neuropathologist (Catherine Humphries) started as Stroke Association Princess Margaret Research Fellow on neuroimaging and neuropathology in SVD, jointly supervised with Colin Smith. Chabriat and colleagues are planning a trial of interventions in a monogenic form of small vessel disease, CADASIL, with input from several COEN partners (Dichgans, Werring, Wardlaw, Benavente). The International Stroke Genetics Consortium has set up an imaging standards subgroup (which includes JM Wardlaw) to improve use of imaging in phenotyping for stroke and dementia gene discovery studies. A publication is accepted in Stroke. Munich collaborators working on various applications. EU Horizon 2020 outline submitted (Dichgans, van Oostenbrugge, Wardlaw. Three groups are working on improved methods for patient stratification and outcome assessment in randomised controlled trials of interventions to prevent progression of small vessel disease and vascular and non-vascular neurodegeneration (Benavente, Chabriat, Wardlaw). Further validation of the derived standard is currently being undertaken by Smith, Wardlaw and Dichgans with Smith leading, including testing the reporting checklist on randomly chosen relevant publications and refining the checklist, expected to report in early 2014. Abstract (E Smith) accepted for International Stoke Conference in February 2015. A multi-centre trial of interventions to prevent small vessel disease progression is being planned in the UK with advice from Benavente and Chabriat. Outline approved by BHF, full submission pending. Application for randomised clinical trial testing two promising agents in a short-term intermediary outcomes trial submitted to Alzheimer's Society. The investment is therefore leading directly to interventions which, if successful, should reduce the impact of the vascular contribution to neurodegeneration.
Start Year 2012
 
Description COEN 
Organisation University of Sydney
Department Westmead Clinical School
Country Australia 
Sector Academic/University 
PI Contribution Development of guidelines for contribution of imaging of small vessel disease.
Collaborator Contribution Development of guidelines for contribution of imaging of small vessel disease.
Impact 2 Lancet Neurology papers in 2013 (see publications) Accepted embedded symposiums in the International Stroke Conference (February 2013), European Stroke Conference (May 2013), VasCog (June 2013), and World Stroke Conference (October 2014) Invited lecture (M Dichgans) at 9th World Stroke Congress, Istanbul (see publications) EU Joint Programme - Neurodegenerative Disease Research grant awarded for "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration", €47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, M Dichgans, F Fazekas, R Schmidt, H Chabriat, C Cordonnier, E Jouvent, MMB Breteler, F Jessen, L Pantoni, GJ Biessels, F-E de Leeuw, MA Ikram, M Vernooij, RJ van Oostenbrugge, C Brayne, IJ Deary, JT O'Brien, PM Matthews, JM Starr, BC Stephan, DJ Werring, E Smith. Lancet Neurology editorial April 2012 (see publications) Methods to evaluate likely underlying mechanisms of SVD are being tested in collaboration between the Austrian Stroke Prevention Study (Fazekas, COEN expert, Gratz) and Edinburgh, including a) evaluation of brain mineral deposition and b) of embolic, atheromatous and intrinsic mechanisms of lacunar stroke in a population study. One paper submitted from collaboration with Fazekas group in Graz. (see publications) Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending. Collaboration around post-mortem imaging methods for examination of individual vascular features is proceeding between investigators in Lille (COEN expert Cordonnier) and Edinburgh. Neuropathologist (Catherine Humphries) started as Stroke Association Princess Margaret Research Fellow on neuroimaging and neuropathology in SVD, jointly supervised with Colin Smith. Chabriat and colleagues are planning a trial of interventions in a monogenic form of small vessel disease, CADASIL, with input from several COEN partners (Dichgans, Werring, Wardlaw, Benavente). The International Stroke Genetics Consortium has set up an imaging standards subgroup (which includes JM Wardlaw) to improve use of imaging in phenotyping for stroke and dementia gene discovery studies. A publication is accepted in Stroke. Munich collaborators working on various applications. EU Horizon 2020 outline submitted (Dichgans, van Oostenbrugge, Wardlaw. Three groups are working on improved methods for patient stratification and outcome assessment in randomised controlled trials of interventions to prevent progression of small vessel disease and vascular and non-vascular neurodegeneration (Benavente, Chabriat, Wardlaw). Further validation of the derived standard is currently being undertaken by Smith, Wardlaw and Dichgans with Smith leading, including testing the reporting checklist on randomly chosen relevant publications and refining the checklist, expected to report in early 2014. Abstract (E Smith) accepted for International Stoke Conference in February 2015. A multi-centre trial of interventions to prevent small vessel disease progression is being planned in the UK with advice from Benavente and Chabriat. Outline approved by BHF, full submission pending. Application for randomised clinical trial testing two promising agents in a short-term intermediary outcomes trial submitted to Alzheimer's Society. The investment is therefore leading directly to interventions which, if successful, should reduce the impact of the vascular contribution to neurodegeneration.
Start Year 2012
 
Description COEN 
Organisation Utrecht University
Department Rudolf Magnus Institute
Country Netherlands 
Sector Academic/University 
PI Contribution Development of guidelines for contribution of imaging of small vessel disease.
Collaborator Contribution Development of guidelines for contribution of imaging of small vessel disease.
Impact 2 Lancet Neurology papers in 2013 (see publications) Accepted embedded symposiums in the International Stroke Conference (February 2013), European Stroke Conference (May 2013), VasCog (June 2013), and World Stroke Conference (October 2014) Invited lecture (M Dichgans) at 9th World Stroke Congress, Istanbul (see publications) EU Joint Programme - Neurodegenerative Disease Research grant awarded for "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration", €47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, M Dichgans, F Fazekas, R Schmidt, H Chabriat, C Cordonnier, E Jouvent, MMB Breteler, F Jessen, L Pantoni, GJ Biessels, F-E de Leeuw, MA Ikram, M Vernooij, RJ van Oostenbrugge, C Brayne, IJ Deary, JT O'Brien, PM Matthews, JM Starr, BC Stephan, DJ Werring, E Smith. Lancet Neurology editorial April 2012 (see publications) Methods to evaluate likely underlying mechanisms of SVD are being tested in collaboration between the Austrian Stroke Prevention Study (Fazekas, COEN expert, Gratz) and Edinburgh, including a) evaluation of brain mineral deposition and b) of embolic, atheromatous and intrinsic mechanisms of lacunar stroke in a population study. One paper submitted from collaboration with Fazekas group in Graz. (see publications) Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending. Collaboration around post-mortem imaging methods for examination of individual vascular features is proceeding between investigators in Lille (COEN expert Cordonnier) and Edinburgh. Neuropathologist (Catherine Humphries) started as Stroke Association Princess Margaret Research Fellow on neuroimaging and neuropathology in SVD, jointly supervised with Colin Smith. Chabriat and colleagues are planning a trial of interventions in a monogenic form of small vessel disease, CADASIL, with input from several COEN partners (Dichgans, Werring, Wardlaw, Benavente). The International Stroke Genetics Consortium has set up an imaging standards subgroup (which includes JM Wardlaw) to improve use of imaging in phenotyping for stroke and dementia gene discovery studies. A publication is accepted in Stroke. Munich collaborators working on various applications. EU Horizon 2020 outline submitted (Dichgans, van Oostenbrugge, Wardlaw. Three groups are working on improved methods for patient stratification and outcome assessment in randomised controlled trials of interventions to prevent progression of small vessel disease and vascular and non-vascular neurodegeneration (Benavente, Chabriat, Wardlaw). Further validation of the derived standard is currently being undertaken by Smith, Wardlaw and Dichgans with Smith leading, including testing the reporting checklist on randomly chosen relevant publications and refining the checklist, expected to report in early 2014. Abstract (E Smith) accepted for International Stoke Conference in February 2015. A multi-centre trial of interventions to prevent small vessel disease progression is being planned in the UK with advice from Benavente and Chabriat. Outline approved by BHF, full submission pending. Application for randomised clinical trial testing two promising agents in a short-term intermediary outcomes trial submitted to Alzheimer's Society. The investment is therefore leading directly to interventions which, if successful, should reduce the impact of the vascular contribution to neurodegeneration.
Start Year 2012
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Aarhus University
Country Denmark 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Alberta Health Services
Country Canada 
Sector Public 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Boston University
Country United States 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Chinese University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Lariboisière Hospital
Country France 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Maastricht University Medical Center+
Country Netherlands 
Sector Hospitals 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation McMaster University
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Medical University of Graz
Country Austria 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation National University of Singapore
Country Singapore 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Radboud University Nijmegen Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation The Otto-von-Guericke University Magdeburg
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University Hospital Carl Gustav Carus Dresden
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University Medical Center Rotterdam
Country Netherlands 
Sector Hospitals 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Bordeaux
Country France 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Calgary
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of California, Davis
Country United States 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Florence
Country Italy 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Iceland
Country Iceland 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Laval
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of New South Wales
Country Australia 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description JPND "HARmoNising Brain Imaging Methods for VaScular Contributions to Neurodegeneration (HARNESS)" 
Organisation Western University
Country Canada 
Sector Academic/University 
PI Contribution Prof Joanna Wardlaw was one of the main researchers on the funding application and is currently helping to coordinate the collaboration.
Collaborator Contribution The objective of HARNESS is to develop standardized methods for using brain scans to diagnose vascular dementia. Over a series of teleconferences and meetings were held to: 1) plan an internet-based repository for instructions on how to do magnetic resonance imaging (MRI) scans to detect vascular dementia, 2) host examples of scans with different kinds of blood vessel diseases, so radiologists and researchers can learn what they look like and practice measuring them, 3) provide instructions for how to test the reliability of MRI scanner measurements, and 4) review new ways to do scans to diagnose vascular dementia.
Impact Too early to say
Start Year 2017
 
Description 11° Congresso Português do AVC, talk by Prof Joanna Wardlaw: "Imaging studies in vascular cognitive impairment" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give a talk at the 11° Congresso Português do AVC (11th Portuguese Stroke Congress) in Porto, Portugal, on 2 February 2016; the talk was "Imaging studies in vascular cognitive impairment".
Year(s) Of Engagement Activity 2017
 
Description Alzheimer's Research UK Manchester and NorthWest Network Centre Science Day, talk by Prof Joanna Wardlaw: "Vascular disease and neurodegeneration - structural and functional insights from neuroimaging in humans" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give at talk at the Alzheimer's Research UK Manchester and NorthWest Network Centre Science Day on 18 May 2016, in Manchester, UK. The talk was entitled: "Vascular disease and neurodegeneration - structural and functional insights from neuroimaging in humans".
Year(s) Of Engagement Activity 2016
URL http://www.alzheimersresearchuk.org/research-projects/alzheimers-research-uk-manchester-north-west-n...
 
Description Prof Joanna Wardlaw feature in Health Matters magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A feature in Health Matters magazine, Winter 2018-2019 issue, P 24-25. Wardlaw, JM. "MRI scans of the brain".
Year(s) Of Engagement Activity 2019
 
Description Prof Joanna Wardlaw lecture "Brain Health: a small matter of the blood vessels" in Edinburgh, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Edinburgh Neuroscience Public Christmas Lecture 2018
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw talk "Cerebral small vessel disease: novel targets for prevention" in Berlin, Germany. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on 'Cerebral small vessel disease: novel targets for prevention' at the 'Dementia Prevention by Stroke Prevention' World Health Summit Satellite Symposium on October 13, 2018 in Berlin.
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw talk "Cerebral vascular dysfunctions detected in human small vessel disease and implications for preclinical studies" in Burlington, VT, USA. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw gave a talk on "Cerebral vascular dysfunctions detected in human small vessel disease and implications for preclinical studies" at The University of Vermont, Burlington, VT on Monday 22, 2018.
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw talk "Does ischaemia play a role in SVD lesion development?" in Montreal, Canada. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw gave a talk on "Does ischaemia play a role in SVD lesion development?" at the 11th World Stroke Congress in Montreal, Canada on October 19, 2018.
Year(s) Of Engagement Activity 2018
 
Description Prof Joanna Wardlaw talk "Mechanisms of small vessel disease" in Seattle, WA, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw gave at talk called "Mechanisms of small vessel disease" to the Neuroscience Department in Seattle, WA, USA, on 1 June 2017.
Year(s) Of Engagement Activity 2017
 
Description Prof Joanna Wardlaw talk "Recent advances in small vessel disease" in Calgary, Canada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw gave at talk called "Recent advances in small vessel disease" to the Stroke Research & Neuroscience Department in Calgary, Canada on 15 June 2017.
Year(s) Of Engagement Activity 2017
 
Description Royal College of Physicians 'Women in medicine: a celebration' project 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal College of Physicians (RCP)'s 'Women in medicine: a celebration' project is a free exhibition of specially commissioned photographic portraits to honour contemporary and historical women in medicine. The project showcased a number of today's leading female clinicians and the women from the history of medicine who have inspired them. Prof Joanna Wardlaw is featured in the project alongside someone who inspired her, Marie Sklodowska Curie: https://www.rcplondon.ac.uk/projects/outputs/women-medicine-joanna-wardlaw-and-marie-curie
Year(s) Of Engagement Activity 2017
URL https://www.rcplondon.ac.uk/events/women-medicine-celebration
 
Description Royal College of Radiologists Research Day, talk by Prof Joanna Wardlaw: "A day in the life of an academic radiologist" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give at talk at the Royal College of Radiologists Research Day on 15 November 2016 in London, UK. The talk was entitled, "A day in the life of an academic radiologist".
Year(s) Of Engagement Activity 2016
 
Description Scottish Church Theology Society, talk by Prof Joanna Wardlaw: "The challenges of modern biology - the brain" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Joanna Wardlaw was invited to give a talk at The Scottish Church Theology Society on 12 January 2016 in Peebles, UK. The talk was entitled: "The Challenge of Modern Biology - The Brain".
Year(s) Of Engagement Activity 2016
 
Description Scottish Radiological Society Annual General Meeting, talk by Prof Joanna Wardlaw: "The Role of Acute Imaging in Stroke" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give at talk at the Scottish Radiological Society's Annual General Meeting on 11 November 2016 in Dundee, UK. The talk was "The role of acute imaging in stroke".
Year(s) Of Engagement Activity 2016
URL http://www.radiology.co.uk/meetings
 
Description Stroke Association's Keynote Lecture given by Prof Joanna Wardlaw "One small vessel stroke? One giant problem for humankind" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact The Stroke Association's Keynote Lecture is a prestigious event that showcases the latest advancements being made in stroke research. In 2016, the Keynote Lecture was held at Lancaster House.

Professor Wardlaw addressed 'small vessel disease' which is the most common cause of vascular dementia. Although vascular dementia is the second most common form of dementia, for too long there has been insufficient research into this disease.
Year(s) Of Engagement Activity 2016
URL https://www.stroke.org.uk/news/keynote-lecture-2016
 
Description Symposium on Small Vessel Disease of the Brain - Prof Joanna Wardlaw gave a talk on "Small vessel disease: stroke and dementia" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw gave a talk at the Symposium on Small Vessel Disease of the Brain organised by Novo Nordisk Fonden, 11 May 2017, Hellerup, Denmark. The talk was on "Small vessel disease: stroke and dementia".
Year(s) Of Engagement Activity 2017
URL http://novonordiskfonden.dk/en/content/small-vessel-disease-brain-epidemic-21st-century
 
Description UK Stroke Assembly, talk by Prof Joanna Wardlaw: "Stroke and dementia: what research tells us" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Joanna Wardlaw was invited to give a talk at the UK Stroke Assembly from 13-14 June 2016 in Nottingham, UK. the talk was entitled: "Stroke and dementia: what research tells us".
Year(s) Of Engagement Activity 2016
URL https://www.stroke.org.uk/take-action/uk-stroke-assembly