CIMA: The Centre for Integrated Research into Musculoskeletal Ageing

Lead Research Organisation: University of Liverpool
Department Name: Institute of Ageing and Chronic Disease

Abstract

Objectives
This proposal will bring together researchers from 3 leading UK Universities to establish a Centre of Excellence that will undertake world-leading research to understand why our bones, joints and muscles function less well as we age and why older people develop clinical diseases of bones, joints and muscles, such as arthritis or osteoporosis. The Centre will also investigate new ways of preventing the deterioration of bones, muscle and joints that occur as we age to help preserve mobility and independence in older people.

Clinical Benefits
Understanding why our bones, joints and muscles function less well as we get older is crucial to improving ways of preventing the decline in musculoskeletal function that occurs in older people and to an understanding of why older people develop diseases such as osteoporosis or arthritis. Our work aims to develop ways of preventing ageing-related changes in bone, joints and muscle which will be acceptable, cost effective and sustainable for everyone who could benefit from them. This will lead to major improvements in the quality of life of older people associated with increased mobility, greater opportunity for independent living and a decreased risk of developing clinical disorders of bones and joints.

Questions: This application will bring together outstanding researchers from the Universities of Liverpool, Newcastle and Sheffield to undertake innovative and integrated studies of the whole musculoskeletal system. These groups have previously studied individual tissues, but will combine together in this innovative Centre to find answers to a number of important questions:
1. What are the common mechanisms that underlie the age-related deterioration in function of joints, bone, tendon, ligaments and muscle?
2. What is the best way of assessing the changes in structure and function of joints, bone, tendons, ligaments and muscle during ageing and how can we develop an integrated approach to assessing the function of the whole musculoskeletal system?
3. What is the best way of assessing whether a treatment can prevent the loss of function of the whole musculoskeletal system during ageing and how can we determine whether an intervention will reduce the risk of musculoskeletal disorders?
4. Which interventions based on changes in physical activity, improved nutrition or drug-based approaches are effective in preserving musculoskeletal function in older people?

Experimental plan: CIMA will:
1. Integrate existing basic science studies on single tissues to study the whole musculoskeletal system. This will bring unique expertise and equipment to identify common mechanisms leading to age-related decline in musculoskeletal tissues. This research will identify new targets for interventions to slow age-related decline in musculoskeletal tissues.
2. Examine different methods to monitor the structure and function of musculoskeletal tissues and develop an integrated assessment of age-related decline in the whole system.
3. Study the changes in the musculoskeletal system in healthy older people and in patients with disorders of musculoskeletal tissues to identify which groups will provide the most information for studies of interventions.
4. Devise new therapies to prevent age-related decline of musculoskeletal tissues based on types of exercise that improve bone, tendon, ligament and muscle function without damaging joints, improved nutrition or new drugs.
5. Train to the highest standard new researchers to increase capacity to address musculoskeletal ageing.

Novelty:
The work of the Centre will be novel in bringing together to address a common problem, the expertise and facilities currently in 3 Universities. It will identify new common mechanisms underlying age-related loss of function of bone, joints, tendons, ligaments and muscle that may provide routes for possible new drug interventions.

Technical Summary

The Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between centres of excellence at the Universities of Liverpool, Newcastle and Sheffield that brings together complementary expertise in skeletal muscle, bone, cartilage and tendon biology, ageing research, nutrition and exercise interventions and clinical excellence in musculoskeletal disorders. CIMA will develop an integrated approach to understanding the processes and effects of ageing in tissues of the musculoskeletal system, how ageing contributes to diseases of the musculoskeletal system and how these processes may be ameliorated or prevented. The three Institutions have developed a strong framework for collaboration and CIMA will provide an outstanding scientific environment that gives researchers access to excellent facilities, cohorts and techniques and will develop a high quality training programme to improve and expand UK and International research capacity in musculoskeletal ageing. A unique feature of CIMA research will be its focus on the whole musculoskeletal system rather than on individual tissue components. We will integrate basic science programmes to understand how intrinsic mechanisms of ageing lead to decline in musculoskeletal function and contribute to musculoskeletal disorders, identify and share current state-of-the-art in monitoring age-related changes in individual musculoskeletal tissues and provide an integrated assessment of musculoskeletal function through use of modelling and systems biology approaches. We will also develop and test novel approaches to reduce age-related deterioration of the musculoskeletal system through nutrition, exercise and pharmacological interventions.

Planned Impact

Who will benefit from this research?
Older people will be the main beneficiaries. Improving the health and quality of life of ageing populations is a major challenge. Projections from the UK Office for National Statistics & Government Actuary Department indicate that by 2050 the proportion of people over 60 in Britain will rise from 21% to ~40%. Decline in musculoskeletal function is a major contributor to health problems in older people. UK industry's pharmaceutical and personal care products sectors will benefit from research which will provide resources to guide development of effective interventions to reduce age-related changes in the musculoskeletal system. With the increasing older population there is demand for anti-ageing products with substantial economic potential for the pharmaceutical and personal care products sectors and improved quality of life for older people. The UK research community will benefit through increased critical mass, new techniques, researcher training and CIMA taking a leading role in national and international research activities in this area.

How will they benefit from this research?
CIMA will identify interventions to reduce age-related decline in the musculoskeletal system. Current recommendations promote physical activity, but there are no validated nutritional, exercise or pharmacological approaches to maintain health of the whole musculoskeletal system during ageing that are demonstrated to be effective and acceptable to target population groups and sustainable. We will develop, pilot and test interventions with widespread benefit for public health to improve mobility, independence and quality of life and with an economic impact through reducing healthcare costs. UK pharmaceutical companies will benefit from the work of CIMA in identifying and validating biomarkers, trial design and therapeutic targets.

What will these impacts be, and what is their importance?
The CIMA programme will identify new intervention targets and optimise interventions to preserve musculoskeletal health, reduce the need for assisted care and enhance quality of life in older people (5-10 years).

CIMA will identify new biomarkers for assessing musculoskeletal ageing and for assessing the impact of interventions to improve musculoskeletal health in older people (5-10 years).

Through direct public engagement and interaction with organisations including Age UK and Arthritis Research UK, CIMA will disseminate findings to the general population by routes including web-based information, flyers and training for health professionals (5 years).

CIMA will expand research capacity by training researchers and clinicians with multidisciplinary skills in ageing research and musculoskeletal biology that are applicable to multiple employment sectors (5 years).

Publications

10 25 50

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Alizadehkhaiyat O (2015) ELECTROMYOGRAPHIC ANALYSIS OF SHOULDER GIRDLE MUSCLES DURING COMMON INTERNAL ROTATION EXERCISES. in International journal of sports physical therapy

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Alizadehkhaiyat Omid (2015) ELECTROMYOGRAPHIC ANALYSIS OF SHOULDER GIRDLE MUSCLES DURING COMMON INTERNAL ROTATION EXERCISES in INTERNATIONAL JOURNAL OF SPORTS PHYSICAL THERAPY

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Almarza D (2017) Genome editing for human osteoarthritis - a perspective. in Osteoarthritis and cartilage

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Armbrecht G (2015) Vertebral Scheuermann's disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

 
Description BBSRC DRINC steering group
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Policy Influence Type Membership of a guideline committee
 
Description Endocrine society guidelines on postmenopausal osteoporosis
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact The Endocrine Society development guidelines for osteoporosis and I was the first author. The article will be published in March 2019.
 
Description MRC Nutrition and Health Review Workshop, 7th - 8th July 2016
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Description MRC Review of Nutrition and Human Health Research, 14 Oct 2016
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Description MRC Review of Nutrition and Human Health research - 17th March
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Policy Influence Type Participation in a advisory committee
 
Description UK Office of Strategic Coordination for Health Research (MRC & NIHR) - member strategic review group on nutrition and health (Jackson)
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Description Amgen ( Cummings / Eastell)
Amount £150,000 (GBP)
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Start  
 
Description Arthritis Research UK (Loughlin, Reynard)
Amount £1,157,000 (GBP)
Funding ID 20771 
Organisation Versus Arthritis 
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End 04/2020
 
Description Arthritis Research UK Project Grant (Wilkinson, Blom, McCloskey)
Amount £244,693 (GBP)
Funding ID 20894 
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Description Arthritis Research Uk ( Frangi / Soler / Jacques / Peel / Paggiosi / Eastell )
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Description BBSRC ( Vasilaki / Whysall)
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Description BBSRC Project Grant (Jackson, McArdle)
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Description COST Action (Bellantuono et al) Horizon 2020
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Description Confidence in Concept (Eastell, Frangi, Pozo Soler)
Amount £37,131 (GBP)
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Description Efficacy and Mechanism Evaluation Board
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Description European Leukodystrophy Association ( Renshaw / Hamilton)
Amount £240,000 (GBP)
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Description Horizon 2020 Intital Training Network (Hannan)
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Amount £123,000 (GBP)
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Description Innovate UK TSB ( Dickinson / Loughlin / Dalgarno / Pearson / Genever
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Description Innovate UK TSB ( Dickinson / Loughlin / Dalgarno / Peason / Genever)
Amount £96,000 (GBP)
Organisation Innovate UK 
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Description Innovative Medicine Initiative (Loughlin)
Amount € 7,500,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
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Start 06/2015 
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Description MRC ( Dockerell / Renshaw )
Amount £2,800,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC ( Renshaw)
Amount £3,300,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC ( Ross / Wilkinson / Eastell )
Amount £49,611 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
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Description MRC ( Van't Hof / Daroszewska / Bou-Gharios / Pisconti / Poulet)
Amount £570,188 (GBP)
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Description MRC (Laird / Whysall / Van't Hof / Bou-Gharios / Clegg / Czanner)
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Organisation Medical Research Council (MRC) 
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Description MRC (Peffers / Clegg / Whysall / Young)
Amount £70,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC (Peffers / Tew / Smagul )
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC Centre Minor Equipment Grant (Jackson)
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Start 03/2016 
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Description MRC Centres Capital Award
Amount £657,000 (GBP)
Funding ID MR/K006312/1 
Organisation Medical Research Council (MRC) 
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Description MRC Doctoral Training Programme (Sheffield, Liverpool, Newcastle, Leeds)
Amount £3,000,000 (GBP)
Organisation MRC Doctoral Training Program 
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Start 09/2016 
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Description MRC NIRG (Pekovic-Vaughan)
Amount £550,000 (GBP)
Organisation Medical Research Council (MRC) 
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Start  
 
Description MRC Programme Grant (Rowan)
Amount £1,500,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC Project Grant ( Jackson/ McArdle)
Amount £670,721 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC Project Grant (Jackson, McArdle, McDonagh, Close)
Amount £670,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC Project Grant (Siervo, Mathers)
Amount £694,000 (GBP)
Organisation Medical Research Council (MRC) 
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Description MRC Project Grant (Stewart, Eastell)
Amount £400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Start 08/2015 
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Description MRC Project Grant (Tew, McDonagh, BouGharios, Milner P)
Amount £510,282 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Description MRC Project grant (Tew, McDonagh, Bou-Gharios)
Amount £510,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description MRC project grant (Jackson,, Barratt-Jolley, McArdle, Vasilaki)
Amount £648,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Start 01/2015 
End 01/2018
 
Description MRC/NIHR EME (Walsh)
Amount £1,522,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Start  
 
Description MRC/NIHR EME (Walsh, Eastell, Hill)
Amount £461,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Start 08/2016 
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Description NC3R (Bellantuono, Skerry)
Amount £365,000 (GBP)
Funding ID NC/K000780/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
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Start 07/2013 
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Description NIH (Jackson, McArdle, Vasilaki, McDonagh)
Amount $1,300,000 (USD)
Organisation National Institute on Aging 
Sector Public
Country United States
Start  
 
Description Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice
Amount $10,500,000 (USD)
Organisation National Institute on Aging 
Sector Public
Country United States
Start  
 
Description PhD Scholarship (Clegg, Peffers)
Amount £116,459 (GBP)
Organisation Serth and Gates Charitable Trust 
Sector Charity/Non Profit
Country Unknown
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Description Programme grant (Renshaw)
Amount £1,204,240 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Description Project Grant (Eastell, Walsh, Hill)
Amount £58,087 (GBP)
Organisation National Osteoporosis Society 
Sector Learned Society
Country United Kingdom
Start 04/2015 
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Description Project Grant (Rowan, Wilkinson)
Amount £49,942 (GBP)
Organisation The JGW Patterson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
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Description Project grant (Wilson, Renshaw, Kadirkamana)
Amount £373,297 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
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Description Pump-Priming (Reynard, Loughlin)
Amount £70,000 (GBP)
Organisation The JGW Patterson Foundation 
Sector Charity/Non Profit
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Description Rare Diseases (Eastell, Walsh)
Amount £200,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
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Description Research Centre (Centre for Brain Ageing and Vitality - Turnbull, Mathers, Trenell et al)
Amount £2,749,620 (GBP)
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Public
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Description Research grant
Amount £346,000 (GBP)
Organisation Novo Nordisk 
Sector Public
Country Denmark
Start 12/2013 
End 11/2016
 
Description Research grant (Bellantuono, Skerry, Viceconti)
Amount £362,776 (GBP)
Funding ID NC/K000780/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
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Description Research grant (Cartmell & Clegg)
Amount £1,200,000 (GBP)
Funding ID MR/M007642/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
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Start 01/2015 
End 12/2017
 
Description Research grant (Cawston)
Amount £21,158 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Research grant (Cooper, McArdle, Lightfoot)
Amount £30,000 (GBP)
Organisation Myositis UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2014 
End 11/2015
 
Description Research grant (Cuthbertson, Daousi & Kemp)
Amount £40,000 (GBP)
Organisation Pfizer Ltd 
Sector Private
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Start  
 
Description Research grant (Cuthbertson, Kemp, Wilding, Craig)
Amount £346,000 (GBP)
Organisation Novo Nordisk 
Sector Public
Country Denmark
Start 12/2013 
End 11/2016
 
Description Research grant (Hounslow, Lacroix, Viceconti, McCloskey et al)
Amount £4,900,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 06/2013 
End 06/2018
 
Description Research grant (Opperman, Buntra, Carr & Bellantuono)
Amount £1,000,000 (GBP)
Organisation Versus Arthritis 
Start 06/2014 
End 05/2019
 
Description Research grant (Reynard & Loughlin)
Amount £171,000 (GBP)
Funding ID 20679 
Organisation Versus Arthritis 
Start 01/2015 
End 12/2017
 
Description Research grant (Vasilaki, McArdle, Sayer)
Amount £10,000 (GBP)
Organisation Physiological Society 
Sector Learned Society
Country United Kingdom
Start 11/2014 
End 10/2015
 
Description Research grant (Wilding, Halford, Cuthbertson, Kemp)
Amount £522,000 (GBP)
Organisation Bristol-Myers Squibb 
Sector Private
Country United States
Start  
 
Description Research grant (Wilson, Renshaw, Chico)
Amount £128,542 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2014 
End 04/2016
 
Description Senior Investigator award extension (Eastell)
Amount £45,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2014 
End 03/2017
 
Description Studentship (McArdle, Vasilaki)
Amount £70,000 (GBP)
Organisation British Society for Research into Ageing 
Sector Learned Society
Country Unknown
Start  
 
Description Studentship (Pekovic-Vaughan, Shanley, Clegg, Goldberg)
Amount £80,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 10/2019
 
Description Studentship (Reynard, Hilkens, Loughlin)
Amount £120,000 (GBP)
Organisation Newcastle University 
Department Randerson Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 09/2019
 
Description The Ruth and Lionel Jacobson Charitable Trust ( Loughlin)
Amount £75,000 (GBP)
Organisation The Ruth and Lionel Jacobson Charitable Trust 
Start  
 
Description The Wellcome Trust (Skerry, Richards, Harrity et al)
Amount £2,950,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 06/2018
 
Description Wellcome Trust ( Poptani / Murray / Clegg / Van't Hof / Wright / Sutton/ Casewell / Halloran / Lipttrott / Mielgo )
Amount £928,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust ( Renshaw / Condliffe)
Amount £250,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Intermediate Clinical Fellowship (Peffers)
Amount £490,931 (GBP)
Funding ID 107471/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 09/2019
 
Description meta-analysis of fracture risk in major medical illness
Amount $200,000 (USD)
Organisation Amgen Inc 
Sector Private
Country United States
Start 06/2017 
End 05/2019
 
Title Neopeptide Analyser (Peffers) 
Description Software tool to identify potential biomarkers from mass spectrometry data. 
Type Of Material Biological samples 
Year Produced 2017 
Provided To Others? Yes  
Impact published in Wellcome Open Research 
 
Title 3D Ankle Model (Birrell) 
Description A novel 3D active appearance model has been constructed from population MRI data from the Newcastle Thousand Families Study (NTFS), as part of a CIMA Clinical Fellowship to Dr Kate Chapman, in collaboration with iMorphics. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? No  
Impact This model will allow ankle structure to be understood & related to biomechanical and lifecourse factors in NTFS & other cohorts. 
 
Title 4D analysis of bone changes following intervention 
Description This computational approach will be used to monitor the spatio-temporal effects of ageing and intervention on the bone , and could be included in a toolkit to monitor age-related musculoskeletal decline. This approach allows detection of early and localised changes in the bone, following intervention, which cannot be detected using standard analysis methods. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? No  
Impact Reduction of the number of animals used. Reduced data variability. Generation of new lines of inquiries with regard to bone response to intervention. 
 
Description CIMA MRes in Musculoskeletal Ageing 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries)
Collaborator Contribution Each partner had provided 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries)
Impact Recruitment of 12 students to the programme for 2013/14 academic year
Start Year 2013
 
Description CIMA MRes in Musculoskeletal Ageing 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries)
Collaborator Contribution Each partner had provided 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries)
Impact Recruitment of 12 students to the programme for 2013/14 academic year
Start Year 2013
 
Description Collaboration with deCODE Genetics 
Organisation deCODE genetics
Country Iceland 
Sector Private 
PI Contribution Collaboration to expand on our genetic and functional analysis of OA risk loci. This has already resulted in a publication in Nature Genetics.
Collaborator Contribution Collaboration to expand on our genetic and functional analysis of OA risk loci.
Impact This has resulted in a publication in Nature Genetics.
Start Year 2016
 
Description 'Arthritis Matter' June 26th 2014, Newcastle University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact A local public engagement event that included patients, carers and fund raisers. Involved a series of short lay talks about the various Centres of Excellence in Newcastle including CIMA. Event was to share information and to stimulate a better understanding of the science and how the knowledge is being translated into patient benefit.

Discussions with patient and carers
Year(s) Of Engagement Activity 2014
 
Description 'Arthritis Matters 2015' - Newcastle University, CIMA-led 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A local public engagement event that included patients, carers and fund raisers. Involved a series of presentations from CIMA researchers based loosely around physical activity and ageing, shorter presentations from CIMA students who had participated in an earlier impact assessment competition, and a workshop session to gain input from attendees regarding the development of a toolkit for decision making and hip replacements (Arthritis Research UK project grant). Also included a session from Arthritis Research UK on involving patients in research.
Year(s) Of Engagement Activity 2015
 
Description 7th NICIS conference, Insitut Pasteur, Paris. June 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Inter-disciplinary discussion exchanging learning from several diverse fields.
Year(s) Of Engagement Activity 2017
URL https://healthmanagement.org/c/icu/event/nicis-neurosciences-in-intensive-care-international-symposi...
 
Description Afternoon public lectures on bone health 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We had an active question and answer session with the general public about how they may better maintain good bone health.
Year(s) Of Engagement Activity 2018
 
Description Arthritis Research UK branch meeting in Appleby, Cumbria 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Prof John Loughlin attended and presented his research group's work.

Unknown
Year(s) Of Engagement Activity 2013
 
Description Bone Research Society Public Lecture and Symposium (McCloskey) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A public lecture series, gave a talk entitled 'What really moves you?' Attendees ranged from school children to older adults.
Year(s) Of Engagement Activity 2016
 
Description CIMA Massive Open Online Course (MOOC) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A Massive Open Online Course (MOOC) aimed at the general public to demystify the ageing process and show learners how their everyday behaviours and choices affect their long-term musculoskeletal health. Course aimed to answer the key questions 1) What is musculoskeletal health? 2) How can exercise benefit the musculoskeletal system? 3) How can diet benefit the musculoskeletal system? There were 8,973 joiners to the course, and 5,219 learners. The average age of learners on the course was higher than average with 76% of the learners aged over 46 years, 63% over 56 years and 31% over 65 years. Following evaluation of the course, of the 450 learners who made an open-text comment, many expressed an intention to change their behaviour as a result of the course. The most common actions were 1) Increasing exercise (particularly resistance exercise) 2) sitting less 3) increasing intake of vitamin-D and calcium 4) eating more healthily.
Year(s) Of Engagement Activity 2016
URL https://www.futurelearn.com/courses/musculoskeletal
 
Description Dutch Society for Research on Ageing conference, Lieden, Netherlands. May 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Preseantation of findings from ongoing research on personalised nutrition and opportunities for application to improve healthy ageing
Year(s) Of Engagement Activity 2017
URL http://www.nvvvo.nl/nvvvo.nl/?lang=en
 
Description Newcastle Nutrition Course 2018. 'Nutrition and ageing: State of the Art' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Following this lecture, there were several discussions with attending medical practitioners.
Year(s) Of Engagement Activity 2018
 
Description Policy Provocations: 'Ageing: more life or just more years?' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Part of debating series with the public at by the University of Liverpool. It featured a panel made up of University of Manchester Emeritus Professor of Geriatric Medicine, Professor Raymond Tallis; Newcastle University's Institute for Ageing and Health Director, Professor Tom Kirkwood; Professor Diana Kuh, Director of the Medical Research Council Unit for Lifelong Health; and Ageing and Sybo Dijkstra, Senior Director at Philips Research UK. The debate is chaired by the University's Executive Pro-Vice-Chancellor, Professor Andrew Derrington. Panel members outlined their views and engaged in Q&A session with the public.

Raised profile of CIMA and ageing research in the region.
Year(s) Of Engagement Activity 2013
 
Description Postmenopausal Health, Joint RCOG/BMS Meeting, 27th Nov 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Presentation by Prof Eugene McCloskey, led to questions and discussion afterwards

Not known
Year(s) Of Engagement Activity 2013
 
Description Public Debate 'Living Well, Ageing Well,' with CMAR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public event held in Nottingham Council House, to share and discuss current research into lifestyle interventions that have a positive effect upon healthy ageing. Presentations generated lots of questions and lively debate afterwards. This was a joint event held in collaboration with the MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research (Universities of Nottingham and Birmingham).
Year(s) Of Engagement Activity 2015
 
Description Translational Aging Research: Challenges and Opportunities, Lorentz Centre workshop, Amsterdam 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Contributed to development of strategy for research in ageing in The Netherlands
Year(s) Of Engagement Activity 2016
 
Description What really moves you? Public lectures on the wonders of your musculoskeletal system - public talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Oral presentation to approx 60-70 general public attendees ranging in age from primary school to retired adults, followed by questions and answers
Year(s) Of Engagement Activity 2016