CIMA: The Centre for Integrated Research into Musculoskeletal Ageing
Lead Research Organisation:
University of Liverpool
Department Name: Institute of Ageing and Chronic Disease
Abstract
Objectives
This proposal will bring together researchers from 3 leading UK Universities to establish a Centre of Excellence that will undertake world-leading research to understand why our bones, joints and muscles function less well as we age and why older people develop clinical diseases of bones, joints and muscles, such as arthritis or osteoporosis. The Centre will also investigate new ways of preventing the deterioration of bones, muscle and joints that occur as we age to help preserve mobility and independence in older people.
Clinical Benefits
Understanding why our bones, joints and muscles function less well as we get older is crucial to improving ways of preventing the decline in musculoskeletal function that occurs in older people and to an understanding of why older people develop diseases such as osteoporosis or arthritis. Our work aims to develop ways of preventing ageing-related changes in bone, joints and muscle which will be acceptable, cost effective and sustainable for everyone who could benefit from them. This will lead to major improvements in the quality of life of older people associated with increased mobility, greater opportunity for independent living and a decreased risk of developing clinical disorders of bones and joints.
Questions: This application will bring together outstanding researchers from the Universities of Liverpool, Newcastle and Sheffield to undertake innovative and integrated studies of the whole musculoskeletal system. These groups have previously studied individual tissues, but will combine together in this innovative Centre to find answers to a number of important questions:
1. What are the common mechanisms that underlie the age-related deterioration in function of joints, bone, tendon, ligaments and muscle?
2. What is the best way of assessing the changes in structure and function of joints, bone, tendons, ligaments and muscle during ageing and how can we develop an integrated approach to assessing the function of the whole musculoskeletal system?
3. What is the best way of assessing whether a treatment can prevent the loss of function of the whole musculoskeletal system during ageing and how can we determine whether an intervention will reduce the risk of musculoskeletal disorders?
4. Which interventions based on changes in physical activity, improved nutrition or drug-based approaches are effective in preserving musculoskeletal function in older people?
Experimental plan: CIMA will:
1. Integrate existing basic science studies on single tissues to study the whole musculoskeletal system. This will bring unique expertise and equipment to identify common mechanisms leading to age-related decline in musculoskeletal tissues. This research will identify new targets for interventions to slow age-related decline in musculoskeletal tissues.
2. Examine different methods to monitor the structure and function of musculoskeletal tissues and develop an integrated assessment of age-related decline in the whole system.
3. Study the changes in the musculoskeletal system in healthy older people and in patients with disorders of musculoskeletal tissues to identify which groups will provide the most information for studies of interventions.
4. Devise new therapies to prevent age-related decline of musculoskeletal tissues based on types of exercise that improve bone, tendon, ligament and muscle function without damaging joints, improved nutrition or new drugs.
5. Train to the highest standard new researchers to increase capacity to address musculoskeletal ageing.
Novelty:
The work of the Centre will be novel in bringing together to address a common problem, the expertise and facilities currently in 3 Universities. It will identify new common mechanisms underlying age-related loss of function of bone, joints, tendons, ligaments and muscle that may provide routes for possible new drug interventions.
This proposal will bring together researchers from 3 leading UK Universities to establish a Centre of Excellence that will undertake world-leading research to understand why our bones, joints and muscles function less well as we age and why older people develop clinical diseases of bones, joints and muscles, such as arthritis or osteoporosis. The Centre will also investigate new ways of preventing the deterioration of bones, muscle and joints that occur as we age to help preserve mobility and independence in older people.
Clinical Benefits
Understanding why our bones, joints and muscles function less well as we get older is crucial to improving ways of preventing the decline in musculoskeletal function that occurs in older people and to an understanding of why older people develop diseases such as osteoporosis or arthritis. Our work aims to develop ways of preventing ageing-related changes in bone, joints and muscle which will be acceptable, cost effective and sustainable for everyone who could benefit from them. This will lead to major improvements in the quality of life of older people associated with increased mobility, greater opportunity for independent living and a decreased risk of developing clinical disorders of bones and joints.
Questions: This application will bring together outstanding researchers from the Universities of Liverpool, Newcastle and Sheffield to undertake innovative and integrated studies of the whole musculoskeletal system. These groups have previously studied individual tissues, but will combine together in this innovative Centre to find answers to a number of important questions:
1. What are the common mechanisms that underlie the age-related deterioration in function of joints, bone, tendon, ligaments and muscle?
2. What is the best way of assessing the changes in structure and function of joints, bone, tendons, ligaments and muscle during ageing and how can we develop an integrated approach to assessing the function of the whole musculoskeletal system?
3. What is the best way of assessing whether a treatment can prevent the loss of function of the whole musculoskeletal system during ageing and how can we determine whether an intervention will reduce the risk of musculoskeletal disorders?
4. Which interventions based on changes in physical activity, improved nutrition or drug-based approaches are effective in preserving musculoskeletal function in older people?
Experimental plan: CIMA will:
1. Integrate existing basic science studies on single tissues to study the whole musculoskeletal system. This will bring unique expertise and equipment to identify common mechanisms leading to age-related decline in musculoskeletal tissues. This research will identify new targets for interventions to slow age-related decline in musculoskeletal tissues.
2. Examine different methods to monitor the structure and function of musculoskeletal tissues and develop an integrated assessment of age-related decline in the whole system.
3. Study the changes in the musculoskeletal system in healthy older people and in patients with disorders of musculoskeletal tissues to identify which groups will provide the most information for studies of interventions.
4. Devise new therapies to prevent age-related decline of musculoskeletal tissues based on types of exercise that improve bone, tendon, ligament and muscle function without damaging joints, improved nutrition or new drugs.
5. Train to the highest standard new researchers to increase capacity to address musculoskeletal ageing.
Novelty:
The work of the Centre will be novel in bringing together to address a common problem, the expertise and facilities currently in 3 Universities. It will identify new common mechanisms underlying age-related loss of function of bone, joints, tendons, ligaments and muscle that may provide routes for possible new drug interventions.
Technical Summary
The Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between centres of excellence at the Universities of Liverpool, Newcastle and Sheffield that brings together complementary expertise in skeletal muscle, bone, cartilage and tendon biology, ageing research, nutrition and exercise interventions and clinical excellence in musculoskeletal disorders. CIMA will develop an integrated approach to understanding the processes and effects of ageing in tissues of the musculoskeletal system, how ageing contributes to diseases of the musculoskeletal system and how these processes may be ameliorated or prevented. The three Institutions have developed a strong framework for collaboration and CIMA will provide an outstanding scientific environment that gives researchers access to excellent facilities, cohorts and techniques and will develop a high quality training programme to improve and expand UK and International research capacity in musculoskeletal ageing. A unique feature of CIMA research will be its focus on the whole musculoskeletal system rather than on individual tissue components. We will integrate basic science programmes to understand how intrinsic mechanisms of ageing lead to decline in musculoskeletal function and contribute to musculoskeletal disorders, identify and share current state-of-the-art in monitoring age-related changes in individual musculoskeletal tissues and provide an integrated assessment of musculoskeletal function through use of modelling and systems biology approaches. We will also develop and test novel approaches to reduce age-related deterioration of the musculoskeletal system through nutrition, exercise and pharmacological interventions.
Planned Impact
Who will benefit from this research?
Older people will be the main beneficiaries. Improving the health and quality of life of ageing populations is a major challenge. Projections from the UK Office for National Statistics & Government Actuary Department indicate that by 2050 the proportion of people over 60 in Britain will rise from 21% to ~40%. Decline in musculoskeletal function is a major contributor to health problems in older people. UK industry's pharmaceutical and personal care products sectors will benefit from research which will provide resources to guide development of effective interventions to reduce age-related changes in the musculoskeletal system. With the increasing older population there is demand for anti-ageing products with substantial economic potential for the pharmaceutical and personal care products sectors and improved quality of life for older people. The UK research community will benefit through increased critical mass, new techniques, researcher training and CIMA taking a leading role in national and international research activities in this area.
How will they benefit from this research?
CIMA will identify interventions to reduce age-related decline in the musculoskeletal system. Current recommendations promote physical activity, but there are no validated nutritional, exercise or pharmacological approaches to maintain health of the whole musculoskeletal system during ageing that are demonstrated to be effective and acceptable to target population groups and sustainable. We will develop, pilot and test interventions with widespread benefit for public health to improve mobility, independence and quality of life and with an economic impact through reducing healthcare costs. UK pharmaceutical companies will benefit from the work of CIMA in identifying and validating biomarkers, trial design and therapeutic targets.
What will these impacts be, and what is their importance?
The CIMA programme will identify new intervention targets and optimise interventions to preserve musculoskeletal health, reduce the need for assisted care and enhance quality of life in older people (5-10 years).
CIMA will identify new biomarkers for assessing musculoskeletal ageing and for assessing the impact of interventions to improve musculoskeletal health in older people (5-10 years).
Through direct public engagement and interaction with organisations including Age UK and Arthritis Research UK, CIMA will disseminate findings to the general population by routes including web-based information, flyers and training for health professionals (5 years).
CIMA will expand research capacity by training researchers and clinicians with multidisciplinary skills in ageing research and musculoskeletal biology that are applicable to multiple employment sectors (5 years).
Older people will be the main beneficiaries. Improving the health and quality of life of ageing populations is a major challenge. Projections from the UK Office for National Statistics & Government Actuary Department indicate that by 2050 the proportion of people over 60 in Britain will rise from 21% to ~40%. Decline in musculoskeletal function is a major contributor to health problems in older people. UK industry's pharmaceutical and personal care products sectors will benefit from research which will provide resources to guide development of effective interventions to reduce age-related changes in the musculoskeletal system. With the increasing older population there is demand for anti-ageing products with substantial economic potential for the pharmaceutical and personal care products sectors and improved quality of life for older people. The UK research community will benefit through increased critical mass, new techniques, researcher training and CIMA taking a leading role in national and international research activities in this area.
How will they benefit from this research?
CIMA will identify interventions to reduce age-related decline in the musculoskeletal system. Current recommendations promote physical activity, but there are no validated nutritional, exercise or pharmacological approaches to maintain health of the whole musculoskeletal system during ageing that are demonstrated to be effective and acceptable to target population groups and sustainable. We will develop, pilot and test interventions with widespread benefit for public health to improve mobility, independence and quality of life and with an economic impact through reducing healthcare costs. UK pharmaceutical companies will benefit from the work of CIMA in identifying and validating biomarkers, trial design and therapeutic targets.
What will these impacts be, and what is their importance?
The CIMA programme will identify new intervention targets and optimise interventions to preserve musculoskeletal health, reduce the need for assisted care and enhance quality of life in older people (5-10 years).
CIMA will identify new biomarkers for assessing musculoskeletal ageing and for assessing the impact of interventions to improve musculoskeletal health in older people (5-10 years).
Through direct public engagement and interaction with organisations including Age UK and Arthritis Research UK, CIMA will disseminate findings to the general population by routes including web-based information, flyers and training for health professionals (5 years).
CIMA will expand research capacity by training researchers and clinicians with multidisciplinary skills in ageing research and musculoskeletal biology that are applicable to multiple employment sectors (5 years).
Publications
Davidson R
(2017)
Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.
in Scientific reports
Deelen J
(2014)
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
in Human molecular genetics
Deepa SS
(2017)
A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse.
in GeroScience
Del Din S
(2016)
Free-living monitoring of Parkinson's disease: Lessons from the field.
in Movement disorders : official journal of the Movement Disorder Society
Del Din S
(2016)
Measuring gait with an accelerometer-based wearable: influence of device location, testing protocol and age.
in Physiological measurement
Dimitri P
(2015)
Leptin may play a role in bone microstructural alterations in obese children.
in The Journal of clinical endocrinology and metabolism
Dobie R
(2014)
Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice.
in The Journal of endocrinology
Dobson R
(2016)
Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity.
in International journal of obesity (2005)
Dodd AW
(2013)
A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression.
in European journal of human genetics : EJHG
Description | BBSRC DRINC steering group |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | Endocrine society guidelines on postmenopausal osteoporosis |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | The Endocrine Society development guidelines for osteoporosis and I was the first author. The article will be published in March 2019. |
Description | UK Office of Strategic Coordination for Health Research (MRC & NIHR) - member strategic review group on nutrition and health (Jackson) |
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Organisation | Medical Research Council (MRC) |
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Sector | Public |
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Description | MRC NIRG (Pekovic-Vaughan) |
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Start |
Description | MRC Programme Grant (Rowan) |
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Organisation | Medical Research Council (MRC) |
Sector | Public |
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Start |
Description | MRC Project Grant ( Jackson/ McArdle) |
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Organisation | Medical Research Council (MRC) |
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Start |
Description | MRC Project Grant (Jackson, McArdle, McDonagh, Close) |
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Organisation | Medical Research Council (MRC) |
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Start |
Description | MRC Project grant (Tew, McDonagh, Bou-Gharios) |
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Organisation | Medical Research Council (MRC) |
Sector | Public |
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Description | MRC project grant (Jackson,, Barratt-Jolley, McArdle, Vasilaki) |
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Organisation | Medical Research Council (MRC) |
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Start |
Description | MRC/NIHR EME (Walsh, Eastell, Hill) |
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Description | NC3R (Bellantuono, Skerry) |
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Start |
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Start |
Description | Programme grant (Renshaw) |
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Sector | Public |
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Sector | Charity/Non Profit |
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Start | 03/2015 |
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Sector | Charity/Non Profit |
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Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Rare Diseases (Eastell, Walsh) |
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Start |
Description | Research Centre (Centre for Brain Ageing and Vitality - Turnbull, Mathers, Trenell et al) |
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Department | Lifelong Health and Wellbeing (LLHW) |
Sector | Academic/University |
Country | United Kingdom |
Start | 05/2014 |
End | 06/2019 |
Description | Research grant |
Amount | £346,000 (GBP) |
Organisation | Novo Nordisk |
Sector | Private |
Country | Denmark |
Start | 12/2013 |
End | 11/2016 |
Description | Research grant (Bellantuono, Skerry, Viceconti) |
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Funding ID | NC/K000780/1 |
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Sector | Public |
Country | United Kingdom |
Start | 09/2012 |
End | 10/2014 |
Description | Research grant (Cartmell & Clegg) |
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Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2017 |
Description | Research grant (Cawston) |
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Sector | Public |
Country | United Kingdom |
Start |
Description | Research grant (Cooper, McArdle, Lightfoot) |
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Organisation | Myositis UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2014 |
End | 11/2015 |
Description | Research grant (Cuthbertson, Daousi & Kemp) |
Amount | £40,000 (GBP) |
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Sector | Private |
Country | United Kingdom |
Start |
Description | Research grant (Cuthbertson, Kemp, Wilding, Craig) |
Amount | £346,000 (GBP) |
Organisation | Novo Nordisk |
Sector | Private |
Country | Denmark |
Start | 12/2013 |
End | 11/2016 |
Description | Research grant (Hounslow, Lacroix, Viceconti, McCloskey et al) |
Amount | £4,900,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2013 |
End | 06/2018 |
Description | Research grant (Opperman, Buntra, Carr & Bellantuono) |
Amount | £1,000,000 (GBP) |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2014 |
End | 05/2019 |
Description | Research grant (Reynard & Loughlin) |
Amount | £171,000 (GBP) |
Funding ID | 20679 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2017 |
Description | Research grant (Vasilaki, McArdle, Sayer) |
Amount | £10,000 (GBP) |
Organisation | Physiological Society |
Sector | Charity/Non Profit |
Country | Global |
Start | 11/2014 |
End | 10/2015 |
Description | Research grant (Wilding, Halford, Cuthbertson, Kemp) |
Amount | £522,000 (GBP) |
Organisation | Bristol-Myers Squibb |
Sector | Private |
Country | United States |
Start |
Description | Research grant (Wilson, Renshaw, Chico) |
Amount | £128,542 (GBP) |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2014 |
End | 04/2016 |
Description | Senior Investigator award extension (Eastell) |
Amount | £45,000 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 04/2014 |
End | 03/2017 |
Description | Studentship (McArdle, Vasilaki) |
Amount | £70,000 (GBP) |
Organisation | British Society for Research into Ageing |
Sector | Learned Society |
Country | United Kingdom |
Start |
Description | Studentship (Pekovic-Vaughan, Shanley, Clegg, Goldberg) |
Amount | £80,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2015 |
End | 10/2019 |
Description | Studentship (Reynard, Hilkens, Loughlin) |
Amount | £120,000 (GBP) |
Organisation | Newcastle University |
Department | Randerson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2015 |
End | 09/2019 |
Description | The Ruth and Lionel Jacobson Charitable Trust ( Loughlin) |
Amount | £75,000 (GBP) |
Organisation | The Ruth and Lionel Jacobson Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | The Wellcome Trust (Skerry, Richards, Harrity et al) |
Amount | £2,950,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2015 |
End | 06/2018 |
Description | Wellcome Trust ( Poptani / Murray / Clegg / Van't Hof / Wright / Sutton/ Casewell / Halloran / Lipttrott / Mielgo ) |
Amount | £928,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Wellcome Trust ( Renshaw / Condliffe) |
Amount | £250,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Wellcome Trust Intermediate Clinical Fellowship (Peffers) |
Amount | £490,931 (GBP) |
Funding ID | 107471/Z/15/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2015 |
End | 09/2019 |
Description | meta-analysis of fracture risk in major medical illness |
Amount | $200,000 (USD) |
Organisation | Amgen Inc |
Sector | Private |
Country | United States |
Start | 05/2017 |
End | 05/2019 |
Title | Neopeptide Analyser (Peffers) |
Description | Software tool to identify potential biomarkers from mass spectrometry data. |
Type Of Material | Biological samples |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | published in Wellcome Open Research |
Title | 3D Ankle Model (Birrell) |
Description | A novel 3D active appearance model has been constructed from population MRI data from the Newcastle Thousand Families Study (NTFS), as part of a CIMA Clinical Fellowship to Dr Kate Chapman, in collaboration with iMorphics. |
Type Of Material | Computer model/algorithm |
Year Produced | 2016 |
Provided To Others? | No |
Impact | This model will allow ankle structure to be understood & related to biomechanical and lifecourse factors in NTFS & other cohorts. |
Title | 4D analysis of bone changes following intervention |
Description | This computational approach will be used to monitor the spatio-temporal effects of ageing and intervention on the bone , and could be included in a toolkit to monitor age-related musculoskeletal decline. This approach allows detection of early and localised changes in the bone, following intervention, which cannot be detected using standard analysis methods. |
Type Of Material | Computer model/algorithm |
Year Produced | 2016 |
Provided To Others? | No |
Impact | Reduction of the number of animals used. Reduced data variability. Generation of new lines of inquiries with regard to bone response to intervention. |
Description | CIMA MRes in Musculoskeletal Ageing |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries) |
Collaborator Contribution | Each partner had provided 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries) |
Impact | Recruitment of 12 students to the programme for 2013/14 academic year |
Start Year | 2013 |
Description | CIMA MRes in Musculoskeletal Ageing |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries) |
Collaborator Contribution | Each partner had provided 20 credits worth of taught module within this new MRes programme. Shared supervision of students and facilities across the partnership (including access to online libraries) |
Impact | Recruitment of 12 students to the programme for 2013/14 academic year |
Start Year | 2013 |
Description | Collaboration with deCODE Genetics |
Organisation | deCODE genetics |
Country | Iceland |
Sector | Academic/University |
PI Contribution | Collaboration to expand on our genetic and functional analysis of OA risk loci. This has already resulted in a publication in Nature Genetics. |
Collaborator Contribution | Collaboration to expand on our genetic and functional analysis of OA risk loci. |
Impact | This has resulted in a publication in Nature Genetics. |
Start Year | 2016 |
Description | 'Arthritis Matter' June 26th 2014, Newcastle University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Participants in your research and patient groups |
Results and Impact | A local public engagement event that included patients, carers and fund raisers. Involved a series of short lay talks about the various Centres of Excellence in Newcastle including CIMA. Event was to share information and to stimulate a better understanding of the science and how the knowledge is being translated into patient benefit. Discussions with patient and carers |
Year(s) Of Engagement Activity | 2014 |
Description | 'Arthritis Matters 2015' - Newcastle University, CIMA-led |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | A local public engagement event that included patients, carers and fund raisers. Involved a series of presentations from CIMA researchers based loosely around physical activity and ageing, shorter presentations from CIMA students who had participated in an earlier impact assessment competition, and a workshop session to gain input from attendees regarding the development of a toolkit for decision making and hip replacements (Arthritis Research UK project grant). Also included a session from Arthritis Research UK on involving patients in research. |
Year(s) Of Engagement Activity | 2015 |
Description | 7th NICIS conference, Insitut Pasteur, Paris. June 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Inter-disciplinary discussion exchanging learning from several diverse fields. |
Year(s) Of Engagement Activity | 2017 |
URL | https://healthmanagement.org/c/icu/event/nicis-neurosciences-in-intensive-care-international-symposi... |
Description | Afternoon public lectures on bone health |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | We had an active question and answer session with the general public about how they may better maintain good bone health. |
Year(s) Of Engagement Activity | 2018 |
Description | Arthritis Research UK branch meeting in Appleby, Cumbria |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Prof John Loughlin attended and presented his research group's work. Unknown |
Year(s) Of Engagement Activity | 2013 |
Description | Bone Research Society Public Lecture and Symposium (McCloskey) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | A public lecture series, gave a talk entitled 'What really moves you?' Attendees ranged from school children to older adults. |
Year(s) Of Engagement Activity | 2016 |
Description | CIMA Massive Open Online Course (MOOC) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A Massive Open Online Course (MOOC) aimed at the general public to demystify the ageing process and show learners how their everyday behaviours and choices affect their long-term musculoskeletal health. Course aimed to answer the key questions 1) What is musculoskeletal health? 2) How can exercise benefit the musculoskeletal system? 3) How can diet benefit the musculoskeletal system? There were 8,973 joiners to the course, and 5,219 learners. The average age of learners on the course was higher than average with 76% of the learners aged over 46 years, 63% over 56 years and 31% over 65 years. Following evaluation of the course, of the 450 learners who made an open-text comment, many expressed an intention to change their behaviour as a result of the course. The most common actions were 1) Increasing exercise (particularly resistance exercise) 2) sitting less 3) increasing intake of vitamin-D and calcium 4) eating more healthily. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.futurelearn.com/courses/musculoskeletal |
Description | Dutch Society for Research on Ageing conference, Lieden, Netherlands. May 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Preseantation of findings from ongoing research on personalised nutrition and opportunities for application to improve healthy ageing |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.nvvvo.nl/nvvvo.nl/?lang=en |
Description | ESRC Healthy & Inclusive Ageing event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on web-based interventions to improve lifestyle behaviours and enhance healthy ageing |
Year(s) Of Engagement Activity | 2021 |
Description | Invited Speaker: 15th EuGMS Annual Congress. "Towards a multidimensional healthy ageing phenotype". Krakow, Poland |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of work towards a panel of biomarkers for assessing healthy ageing |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.eugms.org/2019.html |
Description | Newcastle Nutrition Course 2018. 'Nutrition and ageing: State of the Art' |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Following this lecture, there were several discussions with attending medical practitioners. |
Year(s) Of Engagement Activity | 2018 |
Description | Policy Provocations: 'Ageing: more life or just more years?' |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Part of debating series with the public at by the University of Liverpool. It featured a panel made up of University of Manchester Emeritus Professor of Geriatric Medicine, Professor Raymond Tallis; Newcastle University's Institute for Ageing and Health Director, Professor Tom Kirkwood; Professor Diana Kuh, Director of the Medical Research Council Unit for Lifelong Health; and Ageing and Sybo Dijkstra, Senior Director at Philips Research UK. The debate is chaired by the University's Executive Pro-Vice-Chancellor, Professor Andrew Derrington. Panel members outlined their views and engaged in Q&A session with the public. Raised profile of CIMA and ageing research in the region. |
Year(s) Of Engagement Activity | 2013 |
Description | Postmenopausal Health, Joint RCOG/BMS Meeting, 27th Nov 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Health professionals |
Results and Impact | Presentation by Prof Eugene McCloskey, led to questions and discussion afterwards Not known |
Year(s) Of Engagement Activity | 2013 |
Description | Public Debate 'Living Well, Ageing Well,' with CMAR |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Public event held in Nottingham Council House, to share and discuss current research into lifestyle interventions that have a positive effect upon healthy ageing. Presentations generated lots of questions and lively debate afterwards. This was a joint event held in collaboration with the MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research (Universities of Nottingham and Birmingham). |
Year(s) Of Engagement Activity | 2015 |
Description | Surrey University. "Dietary strategies for longevity and reduced risk of age-related diseases" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Overview of the role of diet in modulating the ageing trajectory and introduction to multi-modal interventions that may enhance healthy ageing. |
Year(s) Of Engagement Activity | 2021 |
Description | Translational Aging Research: Challenges and Opportunities, Lorentz Centre workshop, Amsterdam |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Contributed to development of strategy for research in ageing in The Netherlands |
Year(s) Of Engagement Activity | 2016 |
Description | What really moves you? Public lectures on the wonders of your musculoskeletal system - public talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Oral presentation to approx 60-70 general public attendees ranging in age from primary school to retired adults, followed by questions and answers |
Year(s) Of Engagement Activity | 2016 |