A new collaborative ultra-high field MRI facility for dementia and neuroscience research

Lead Research Organisation: University of Cambridge
Department Name: Clinical Neurosciences

Abstract

Magnetic Resonance Imaging (MRI) has revolutionised the study of the brain and brain diseases like dementia over the last 20 years. Conventional MRI scanners have their limitations however. We will therefore build an "ultrahigh-field" MRI, which offers a major step forward in how clearly one can study the brain's structure, function and chemistry. This new scanner will be dedicated to the challenge of dementia, supported by scientific work to understand the normal brain and advanced analysis. It will be a major contributor to the UK Dementia Platform, a unique and radical approach to join up medical research across the country's specialist centres and drug company partners in the fight against dementia.
The new "7T" scanner will be built on the Cambridge Biomedical Campus, next to Addenbrookes Hospital. It is a collaboration between Cambridge University and the Medical Research Council's Cognition and Brain Sciences Unit (CBSU), working closely with the NHS. We will use the new scanner to detect and characterise over time the major brain diseases like Alzheimer's, Stroke and Parkinson's Disease.
With our ageing population, the number of people suffering from dementia is likely to increase from the current level of 800,000. The need is urgent to identify people in the earliest stages of such diseases, or even before symptoms, in order to test treatments that combat dementia. Cambridge is ideally suited for this research, because of i) its existing expertise in dementia and MRI brain scanning, ii) its key role in national initiatives to understand dementia and the healthy ageing process, iii) its collaborations with major pharmaceutical companies to develop new treatments, and iv) the existence of large cohort studies that track normal ageing over decades, and groups of research volunteers who, because of genetics or lifestyle, are at-risk of dementia.
MRI is a very versatile technology. MRI scanners can be "tuned" to measure the grey matter (home to most of the brain cells), white matter (the wiring of the brain), the major chemicals in the brain and microscopic effects of dementia. MRI can also measure brain function, allowing researchers to map the brain areas needed for attention, memory or language. The new scanner gives much greater detail across the entire brain, allowing researchers to understand how the brain works as a whole while still seeing detail at a sub-millimetre scale. This detail is important for diseases like Alzheimer's and Parkinson's, for which small and deep parts of the brainstem are critical but difficult to see with conventional MRI.
Moreover, the increased detail offered by ultrahigh field MRI opens the window on an important level of organisation in the brain: the thin layers of the surface of the brain, which have until recently only been studied with invasive recordings. With the new scanner, we can safely study this fundamental level of brain organisation in humans. This will accelerate our scientific understanding of the basic workings of the brain. This draws on the very large community of brain researchers in Cambridge, to investigate, for example, the i) brain changes that put some people at risk of addiction, ii) brain networks linked to obesity, iii) how the brain normally ages, and why some people are resilient as they get older, and iv) how the brain matures through teenage years, when major mental illness like schizophrenia normally begin. Other medical researchers will use the scanner to understand i) recovery of the brain after head injury, ii) the brain systems implicated in pain, and iii) stroke and other disorders associated with impairments in the brain's blood supply.
The depth and breadth of brain research is why the University of Cambridge and partners are planning to join together with the Medical Research Council to invest in this breakthrough technology. The ultrahigh-field MRI will advance both basic and medical research, to improve the health of the nation.

Technical Summary

The resolution of 7T MRI will be used to study the pathogenesis of dementia, mechanisms of resilience, and response to therapy in terms of structure (volumetric and diffusion weighted), function (BOLD) and spectroscopy. Sensitivity to iron deposition by quantitative susceptibility mapping is especially relevant to Alzheimer's disease, while structural and functional changes in vasculature will be examined as markers and targets in stoke, dementia and Huntington's disease. We will delineate the aetiological role of small but critical subcortical structures (eg hypothalamus, brainstem nuclei, hippocampal subfields). Columnar and laminar resolution of 7T fMRI will be used to understand the neuronal code, testing the predicted functional dissociations between cortical layers for hierarchical information processing. The cross linking of neurochemistry (MRS) with functional and structural data will reveal mechanisms of individual differences, in health and disorders, and potential stratification of therapeutic strategies. The new facility is part of the UK7T network, to promote knowledge transfer, data sharing, training, and coordinated of magnet supply. WBIC and CBSU have Master Research Agreements with Siemens and costs follow a Siemens 7T review, but tendering is open to all manufacturers. We require a minimum of 70mT/m gradients, 8 channel parallel transmission, 32 channel receiver, multinuclear spectroscopy and high order shimming. WBIC is controlled through a Clinical Radiology Information system to collect and monitor data, research protocols and scheduled transfer to PACS for long term secure storage, and secure access control. The proposed high performance informatics hub (data management plan) proposes to increase UoC data analysis capacity from 256 to 1024x16 Gb cores, fast user access to data and efficient parallel processing (using GRIDengine). A new informatics hub enhances integration with NHS systems and high volume data sharing with multisites (eg UKDP).

Planned Impact

Through the scientific program and investigators in the Case for Support, the new 7T facility in Cambridge will achieve Academic and Clinical Impacts on the major disorders of the brain: dementia, stroke, mental health and cognitive decline with ageing. In addition, we anticipate breakthroughs in understanding the normal human brain, its neuronal codes and network organisation.
Early Academic impacts include (i) the establishment of state of the art ultra-high imaging facility that will be widely used, ensuring that the Cambridge Biomedical Campus remains internationally competitive as a leading neuroscience centre; (ii) through our membership of the UK 7T network and the UK Dementias Platform, this facility will ensure the UK as a whole is seen as a global academic leader in MR imaging, especially relevant as MRI was discovered here; (iii) we will enhance the UK's competitive research advantage in biomedical imaging and maximize the impact of the MRC's investment across several areas of neuroscience, healthy ageing and dementia. The novel interdisciplinary programmes will advance knowledge globally, together with development and application of innovative methodologies to increase the UK knowledge economy. The evident long running impact of the MRCs intramural Cognition and Brain Sciences Unit, a key partner in this facility, will be amplified through access to cutting edge technologies with 7T MRI.
Early clinical scientific impact: we recognise that full clinical and health economic impact can take several years to fulfil, but we anticipate early clinical impacts in several areas. For example, greater sensitivity to plasticity underpins interventional studies for healthier cognitive ageing, in population derived cohorts. Early translation of basic discoveries to clinical disorders - with new therapeutic targets - is made possible, for example in the ability to test the vascular hypothesis in Huntington's disease, iron dysregulation in addiction, or CNS disorders in obesity.
Longer term health and economic impact come from better understanding, diagnosis and management of dementia, and thereby improved health, wellbeing and the UK economy. The 7T system will be a focus for training the next generation of researchers, both those involved in the study of the clinical disorders being examined, and methodologists to advance technological developments. The Facility coalesces a critical mass for exceptional teaching and learning, working closely with key academic groups locally (in the Schools of Medicine and Biological Sciences and the MRC Cognition and Brain Sciences Unit) and internationally.
Our longer term impact (~5 years) is not only to be measured through the high impact publications, major new grant awards, or even the training of a new cohort of students, researchers and future academic leaders. Our close integration with NHS services at local, regional and national level will ensure that advances are rapidly translated and disseminated for maximum early patient benefit. The imaging facility will catalyse inward commercial investment, including our partners in global pharmaceutical companies, with excellent prospects that innovations will lead to successful commercialisation.
Through our strong links with national bodies and guideline groups (e.g. NICE, MHRA, EFNS) we can ensure that academic advances at 7T imaging diffuse quickly to inform wider evidence based policy making and commissioning, directly and by guiding the translation to widely available systems and novel interventions. With increasing public interest and awareness of imaging and brain disorders such as dementia, the outward facing side of the Facility will increase public engagement with research in general, and with research in imaging and dementia in particular. This will be facilitated through our PPI programme and our links with local and national patient groups and other third sector organisations, most especially patient charities.
 
Title Pint of Science 
Description Pint of Science festival presentations in pubs, bringing research progress and ideas to the public. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2018 
Impact Wide public interest -sell out events 
 
Description Dr M Malpetti - Invited contribution to the World Alzheimer Report 2021
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Publication to serve as reference for students and practitioners.
URL https://www.alzint.org/u/World-Alzheimer-Report-2021.pdf
 
Description Expert Advisor on Trond Mohn Foundation 2021
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact The foundation continues to offer research grants to promising researchers from Norwegian universities and university hospitals.
 
Description Invited abstract reviewing board member at Tau2022 conference - Dr M Malpetti
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
Impact Served as subject specific reviewer.
 
Description Invited abstract reviewing board member at the European Molecular Imaging Meeting - Dr M Malpetti
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Served as subject specific reviewer.
 
Description Invited co-authorship for a systematic review - Dr M Malpetti
Geographic Reach Multiple continents/international 
Policy Influence Type Contribution to new or Improved professional practice
Impact Publication in a major journal.
 
Description UHF Research Review in Parkinsonism
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
 
Description "Structural Characterization of the human locus coeruleus and substantia nigra at 7 Tesla" awarded to Dr Cat Rua
Amount £10,000 (GBP)
Organisation NIHR Cambridge Dementia Biomedical Research Unit 
Sector Public
Country United Kingdom
Start 09/2018 
End 10/2019
 
Description A new noradrenergic strategy for treatment of PSP
Amount £653,896 (GBP)
Funding ID MR/P01271X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2020
 
Description ABN Research Fellowship (Cope)
Amount £180,000 (GBP)
Funding ID RG78594 
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2015 
End 11/2018
 
Description ABN fellowship to Thomas Cope
Amount £179,988 (GBP)
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description ARUK funding to Thomas Cope
Amount £5,000 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK network pilot grant
Amount £5,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
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Description Adaptive decision templates in the human brain
Amount £1,344,200 (GBP)
Funding ID 205067/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
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Start 09/2017 
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Description BRC/NIHR Pilot grant to Thomas Cpe
Amount £10,000 (GBP)
Organisation Hungarian Academy of Sciences (MTA) 
Department Biological Research Centre (BRC)
Sector Academic/University
Country Hungary
Start  
 
Description Biomedical Research Centre Dementia Theme
Amount £118,000,000 (GBP)
Funding ID RG85367 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
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Start 03/2017 
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Description Chris Rodgers - Wellcome Trust Sir Henry Dale Fellowship extension
Amount £633,000 (GBP)
Funding ID 098436/Z/12/B 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2018 
End 01/2021
 
Description Clinical research infrastructure
Amount £1,500,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 03/2016 
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Description Clinical research infrastructure
Amount £6,995,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2015 
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Description Deuterium metabolic imaging at ultra-high field (7T) to probe glucose uptake and metabolism without radioactivity as an alternative to PET
Amount £99,840 (GBP)
Organisation National Institute for Health Research 
Department NIHR Cambridge Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 12/2020 
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Description Gates Cambridge PhD scholarship for Belinda Ding.
Amount £126,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 10/2021
 
Description Grant to Catarina Rua: "Unravelling cortical degeneration in dementia disorders with in vivo layer-dependent transient saturation transfer MRI at 7 tesla"
Amount £4,350 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2019 
End 08/2020
 
Description H2020 FET-OPEN grant
Amount £3,100,000 (GBP)
Organisation European Union 
Sector Public
Country European Union (EU)
Start 05/2018 
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Description Industrial collaboration project
Amount £30,000 (GBP)
Organisation Siemens Healthcare 
Department Siemens Healthcare Ltd
Sector Private
Country United Kingdom
Start 09/2021 
End 09/2024
 
Description Inflammation in frontotemporal lobar degeneration - from diagnosis and prognosis to clinical trials - Dr M Malpetti
Amount £495,687 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2022 
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Description JPND EUFIND
Amount £30,000 (GBP)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 09/2016 
End 10/2017
 
Description MRC DTP PhD studentship for Minghao Zhang
Amount £175,728 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description MRC Partnership grant for UK7T
Amount £220,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description Masters studentship from National Scholarship Programme of the Slovak Republic for Stanislav Fristyk "Absolute quantitation of cardiac energy metabolites using phosphorus MRS"
Amount € 0 (EUR)
Funding ID Unknown 
Organisation Government of the Republic of Slovakia 
Sector Public
Country Slovakia
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Description Measuring microscopic changes at the macroscopic level in frontotemporal dementia - Fellowship to Sanne S. Kaalund
Amount 400,000 kr. (DKK)
Funding ID R232-2016-2333 
Organisation Lundbeck Foundation 
Sector Charity/Non Profit
Country Denmark
Start 07/2017 
End 07/2019
 
Description Metabolic Imaging at Cambridge 7T Terra MRI
Amount £70,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
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Start 09/2018 
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Description Metabolic Imaging at the Cambridge 7T Terra MRI
Amount £50,000 (GBP)
Organisation Newton Fund 
Sector Public
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Start 09/2018 
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Description Newton Trust
Amount £50,000 (GBP)
Organisation Newton Fund 
Sector Public
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Description Non-invasive detection of succinate in myocardial ischaemia using magnetic resonance spectroscopy
Amount £49,904 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 11/2020 
End 07/2021
 
Description Non-ionizing Metabolic Imaging for predicting the effect of and guiding Therapeutic Interventions
Amount € 2,500,000 (EUR)
Funding ID 101058229 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 03/2022 
End 09/2024
 
Description PhD studentship for Carina Graf
Amount £39,023 (GBP)
Organisation Armstrong Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2021 
End 03/2024
 
Description PhD studentship for Mike Beck: A compact bulk superconducting magnet for next-generation medical imaging
Amount £69,309 (GBP)
Funding ID PhD studentship for Mick Beck - supervisors Mark Ainsle and Chris Rodgers 
Organisation Armstrong Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 09/2023
 
Description PhD studentship for Mr Minghao Zhang
Amount £205,728 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description PhD studentship for Ms Carina Graf
Amount £25,767 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 09/2020 
End 09/2023
 
Description Pilot studies in BRC portfolio - LC imaging and addiction
Amount £20,000 (GBP)
Organisation Cambridge University Hospitals NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 07/2018 
End 03/2019
 
Description Restoring noradrenergic function to improve apathy in Parkinson s disease to Claire O Callaghan
Amount £49,677 (GBP)
Funding ID RG90797 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 07/2018
 
Description Siemens
Amount £0 (GBP)
Organisation Siemens Healthcare 
Sector Private
Country Germany
Start 03/2016 
End 03/2016
 
Description Visiting Professorship (Lundbeck Foundation, Danish Research Centre for Magnetic Resonance) - Prof James B Rowe
Amount 150,000 kr. (DKK)
Organisation Lundbeck Foundation 
Sector Charity/Non Profit
Country Denmark
Start 08/2019 
End 12/2019
 
Description What causes lacunar stroke? A 7T magnetic resonance imaging study
Amount £293,089 (GBP)
Funding ID PG/19/74/34670 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2021 
End 03/2024
 
Description mOrgan Re-perfusor perfused Porcine Heart assessment with Magnetic Resonance Imaging (MORPH-MRI)
Amount £48,968 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 06/2019 
End 06/2020
 
Title 7T facility 
Description New facility established for ultrahighfield MRI for dementia research and cognitive neuroscience 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2016 
Provided To Others? Yes  
Impact New MRC funded 7T research network established. 
 
Title A Protocol for Ultra-High Field Laminar fMRI in the human brain 
Description 1. Ultra-high field (UHF) fMRI across cortical depth. We have advanced high resolution EPI sequences for UHF imaging on the Cambridge 7T scanner and developed a rigorous pipeline for the analysis of sub-millimetre resolution fMRI including correction of vasculature-related artefacts. We have developed this pipeline as an open access tool, validated it across three different projects (publications in Current Biology, eLife, J Neuroscience) and published a protocol paper (STAR Protocols, in press). 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2021 
Provided To Others? Yes  
Impact 1. Ultra-high field (UHF) fMRI across cortical depth. We have advanced high resolution EPI sequences for UHF imaging on the Cambridge 7T scanner and developed a rigorous pipeline for the analysis of sub-millimetre resolution fMRI including correction of vasculature-related artefacts. We have developed this pipeline as an open access tool, validated it across three different projects (publications in Current Biology, eLife, J Neuroscience) and published a protocol paper (STAR Protocols, in press). 
 
Title High resolution MR Spectroscopy imaging on the Cambridge 7T scanner for increased GABA detectability 
Description We have advanced high resolution MR Spectroscopy imaging on the Cambridge 7T scanner for increased GABA detectability. We have optimised single voxel MRS sequences to achieve 15 mm isotropic resolution. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2021 
Provided To Others? Yes  
Impact We have advanced high resolution MR Spectroscopy imaging on the Cambridge 7T scanner for increased GABA detectability. We have optimised single voxel MRS sequences to achieve 15 mm isotropic resolution. 
 
Title LC atlas 
Description An atlas of locus ceruleus, currently as submisison in BioRxiv and and awaiting reviewers approval in Neuroimagine. This work is led by Dr Rong Ye. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2020 
Provided To Others? Yes  
Impact Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. The LC can be identified in vivo using non-invasive magnetic resonance imaging techniques which have potential as biomarkers for detecting and monitoring disease progression. We created a probabilistic atlas of the LC from 53 healthy older volunteers (52-84 years) using a sensitive magnetisation transfer sequence and ultrahigh field 7T MRI to investigate the LC structure in vivo at high-resolution. We would like to make the atlas available on NITRC for researchers, for replication or to facilitate accurate LC localisation and unbiased contrast extraction in future cognitive and clinical studies. 
 
Title Sequence development and optimisation for 7T research 
Description New sequences for brain and mental health research at 7T 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? Yes  
Impact Many studies are underway, but these have yet to be published, or to have reached health policy. Our progress has contributed to the national MR debate on higher field imaging in the UK, including nascent proposals for 14T imaging as a national research unit 
URL https://www.wbic.cam.ac.uk/facilities/7t-terra
 
Title Siemens collaboration 
Description We have negotiated research agreements with Siemens for 4 areas of collaborative development in MRI physics at 7T with the 7T physics group. These include developments in parallel transmit methods in the brain and body; developments in MR spectroscopy; and developments in whole-body metabolic imaging at 7T. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact Impacts are expected during the course of the partnership 
 
Title UK7T network harmonised protocols, pulse sequences and analysis pipelines 
Description We have published together with the UK7T network a set of harmonised protocols, and make the associate pulse sequences and analysis pipelines available subject to the normal formalities for Siemens and Philips 7T MRI platforms. This is a companion set of tools linked to a paper https://www.sciencedirect.com/science/article/pii/S1053811919309267 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2019 
Provided To Others? Yes  
Impact The UK7T network study has been an inspiration to a bid just submitted by the EUFIND consortium to the JPND scheme. (Sadly the UK chose not to participate in this funding round, otherwise we would have played a key part in the proposed study. We remain also close named collaborators.) 
URL https://ora.ox.ac.uk/objects/uuid:55ca977f-62df-4cbf-b300-2dc893e36647
 
Title DPUK 7T data sharing 
Description Agreement on data sharing for 7T images using DPUK XNAT platform 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact pending 
 
Title MRC Dementia Platform UK 
Description The DPUK is creating the world's largest population study for use in dementias research, bringing together two million participants aged 50 and over, from 22 existing study groups within the UK. Included are people from the general population, people known to be at-risk of developing dementia, and people diagnosed with early-stage dementia. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact By adding to information that we already know about the participants (such as their diet, exercise habits and previous infections) we hope to identify cognitive, genetic, physiological and imaging measures (biomarkers) to understand who is at risk of developing dementia and why the progression of dementia varies from person to person. The DPUK is taking a new approach that considers what is happening to the health of the person - looking not just at the brain but at the brain in the context of the whole body - to identify those changes that may best be associated with the early stages of dementia. Emerging evidence has linked the development of dementia with inflammatory, cardiovascular and metabolic events and disorders, and the DPUK will be able to test these interactions, potentially identifying new treatment options to both manage symptoms, in the near term, and for preventive approaches in the longer term. The platform will further allow the testing and validation of novel hypotheses by studying and comparing data from different DPUK cohorts. This will provide valuable feedback to inform future mechanistic research for example using stem cells or animal models. 
URL http://www.mrc.ac.uk/research/facilities/dementias-platform-uk/
 
Description Advanced neuro-spectroscopy 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution My group have implemented protocols and are developing advanced pulse sequences for MR spectroscopy and imaging in the human brain by 7T MRI. We have applied these Prof Rowe to study patients with dementias and COVID19, with Prof Kourzi to study cognitive processes in adaptive learning, and with Prof Henson to study semantic processing and the methods of laminar-resolved fMRI.
Collaborator Contribution Prof Rowe is an internationally recognised expert in dementias. He brings access to patients and to a large lab team to maximise the impact of our 7T MRI methods developments. Prof Kourtzi is an internationally recognised expert in adaptive learning and cognitive neuroscience. She brings access to a research group who specialise in studying learning processes. We have shown changes in GABA associated with a visual learning paradigm. Prof Henson is an internationally recognised expert in cognitive neuroscience and fMRI analysis. He brings access to his own research group and the teams at the MRC Centre for Brain Cognition in Cambridge.
Impact Papers/preprints: xx. Jia K, Zamboni E, Rua C, Reis Goncalves N, Kemper V, Ka Tsun Ng A, Rodgers CT, Williams GB, Goebel R, Kourtzi Z. A Protocol for Ultra-High Field Laminar fMRI in the human brain. Submitted to STAR Protocols. Preprint DOI: 10.17863/CAM.60568 xx. Huang P, Correia MM, Rua C, Rodgers CT, Henson RN, Carlin JD. Correcting for Superficial Bias in 7T Gradient Echo fMRI. Bioarxiv DOI 10.1101/2020.11.20.392258. Submitted to NeuroImage. 55. Rong Y, Rua C, O'Callaghan C, Jones PS, Hezemans F, Kaalund SS, Tsvetanov KA, Rodgers CT, Williams GB, Passamonti L, Rowe JB. An in vivo Probabilistic Atlas of the Human Locus Coeruleus at Ultra-high Field. Neuroimage. In Press. 54. Rua C, Clarke, WT, Driver ID, Mougin O, Morgan AT, Clare S, Francis S, Muire K, Porter D, Wise R, Carpenter TA, Williams GB, Rowe JB, Bowtell R, Rodgers CT. Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study. NeuroImage. In Press. DOI: 10.1016/j.neuroimage.2020.117358 52. Jia K, Zamboni E, Kemper V, Rua C, Reis Goncalves N, Ka Tsun Ng A, Rodgers CT, Williams GB, Goebel R, Kourtzi Z. Recurrent processing drives perceptual plasticity. Current Biology. In Press. DOI: 10.1016/j.cub.2020.08.016 51. Murley AG, Rouse MA, Jones PS, Ye R, Hezemans FH, O'Callaghan C, Frangou P, Kourtzi Z, Rua C, Carpenter TA, Rodgers CT, Rowe JB. GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition. NeuroImage 2020. DOI: 10.1093/brain/awaa305 Abstracts: 69. Rua C, O'Callaghan C, Passamonti L, Jones PS, Tsvetanov K, Rowe J, Ye R, Carpenter TA, Rodgers CT, Williams GB. Multi-modal 7T imaging of the Locus Coeruleus in healthy older adults. Proc. ISMRM 2019 (digital poster). 80. Rua C, Claire O'Callaghan, Ron Ye, Luca Passamonti, P Simon Jones, Williams GB, Rowe JB, Rodgers CT. In-vivo characterization of the biochemical properties of the locus coeruleus and substantia nigra in healthy controls and Parkinson's disease. (digital poster) 84. Rua C, Sanne Kaalund, Rowe JB, Rodgers CT, Williams GB. Layer-dependent Transient Saturation Transfer MRI at 7T. (digital poster) 93. Rua C, Llera A, Mougin O, Costagli M, Yakupov R, Bowtell R, Rowe JB, Rodgers CT. Linked Independent Component Analysis for Denoising multi-centre 7T MRI data. 97. Graf C, Clarke WT, Rua C, Newcombe VFJ, Lupson VC, Manktelow A, Chatfield DA, Sawcer SJ, Outtrim JG, Ersche K, Bullmore ET, Menon DK, Finnegan SL, McDonald R, Clare S, Ezra M, Rodgers CT, Pattinson K, Rowe JB. Two-site 7T 1H-MRS study in brainstem of "long COVID" patients. 99. Rua C, Rodgers CT, Newcombe VFJ, Manktelow A, Chatfield DA, Sawcer SJ, Outtrim JG, Lupson VC, Stamatakis EA, Williams GB,Clarke WT, Ersche KD, Pattinson K, Bullmore ET, Menon DK, Rowe JB. Characterization of brain susceptibility changes in post-hospitalisation COVID-19 patients at 7 Tesla.
Start Year 2017
 
Description Cambridge 7T consortium 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming the new University-MRC partnership and Cambridge 7T consortium. Full access to new facility for both partners.
Collaborator Contribution Staff allocation for physics support and adjunctive technologies for participant interaction.
Impact Multidisciplinary - dementia, neurology, psychiatry, development and ageing, cognitive neuroscience and physics. New head of 7T department has been recruited.
Start Year 2015
 
Description Cambridge Centre for Parkinson-Plus (CCPP) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinical Research Programme 1 - Biomarker investigation Clinical Trial 1: Atomoxetine in PSP patients
Collaborator Contribution several
Impact publications pending
Start Year 2018
 
Description Cambridge Engineering superconductivity group 
Organisation University of Cambridge
Department Cambridge Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating on the design of novel PERMANENT superconducting magnets with trapped flux for MRI. I cosupervise a PhD student Mr Mark Beck with Dr Mark Ainslie from the Engineering Dept. My contribution is to understand the necessary specification of magnet, to scope opportunities for impact in the imaging field beyond normal whole-body human MRI, and in due course I will oversee the construction of a demonstration MRI imaging system using custom open-source electronics for the console. I serve on the scientific advisory panel for an EPSRC project "Large Bulk (RE)BCO superconducting magnets for desktop NMR/MRI". https://gow.epsrc.ukri.org/NGBOViewGrant.aspx?GrantRef=EP/T014679/1
Collaborator Contribution Dr Ainslie and Mr Beck are designing the new magnet to be used in this novel imaging system.
Impact Mr Beck's Y1 research report. COVID19 is making experimental science very challenging at this time.
Start Year 2019
 
Description Claire O Callaghan - Restoring noradrenergic function to improve apathy in Parkinson s disease 
Organisation University of Cambridge
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Input on study design
Collaborator Contribution Study design, will do data collection and analyses, publications pending
Impact publications still pending
Start Year 2017
 
Description Collaboration with Dr Ece Kocagoncu for NTAD (Dr A Jafarian) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on data analysis of test-retest data from NTAD.
Collaborator Contribution Availability of NTAD data.
Impact Title: Test-reTest reliability of dynamic casual modelling of resting states MEG data of Alzheimer patients.
Start Year 2022
 
Description Collaboration with Royal Papworth Hospital 
Organisation Royal Papworth Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution My group have shown proof of principle for MRI and MRS study of hearts perfused with the mORGAN reperfuser from Royal Papworth Hospital. We are using this with transplant surgeon Prof Large to assess the effect of ex vivo perfusion on hearts and their suitability for transplant. We began in porcine hearts and will soon start with human hearts (funded, delayed by COVID19). We have shown that we can see epi and endocardial perfusion which is of key interest in preparing hearts from non-beating donors for transplant. We also see an array of metabolic changes.
Collaborator Contribution Prof Large's team are leading the world in cardiac transplant from non-beating donors. We are working with them to refine their technology for perfusion.
Impact We have exciting pilot data but our scans were suspended due to COVID19 so we have not acquired the numbers we wish to for publication yet.
Start Year 2019
 
Description Covid19 Neuroscience Group @7T 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution New program of research into acute and chronic effects of COVID19 on the brain, including respiratory, cognitive and mental health effects Data collection of inpatients, and those recovering, from severe COVID19, and innovations in brain stem neurochemical imaging
Collaborator Contribution Expertise in spectroscopy and respiratory control from the brain Expertise in remote cognitive testing and normative data
Impact Pending publications Conference papers accepted, ISMRN, BNA
Start Year 2020
 
Description Covid19 Neuroscience Group @7T 
Organisation University of Oxford
Department Oxford Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution New program of research into acute and chronic effects of COVID19 on the brain, including respiratory, cognitive and mental health effects Data collection of inpatients, and those recovering, from severe COVID19, and innovations in brain stem neurochemical imaging
Collaborator Contribution Expertise in spectroscopy and respiratory control from the brain Expertise in remote cognitive testing and normative data
Impact Pending publications Conference papers accepted, ISMRN, BNA
Start Year 2020
 
Description Deuterium metabolic imaging 
Organisation Cancer Research UK Cambridge Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution I am implementing an approach for deuterium magnetic resonance imaging on the 7T MRI system in Cambridge to trace glucose uptake and metabolism. In this collaboration with Prof Brindle (CRUK-CI) and Dr Mair (Neurosurgery) and others, I am leading the technical development for 7T.
Collaborator Contribution Prof Brindle has extensive experience of DMI in preclinical settings, including in glioblastoma tumour models. Dr Mair brings access to glioblastoma patients undergoing surgery. We plan to perform human studies imminently.
Impact No outputs yet.
Start Year 2018
 
Description Deuterium metabolic imaging 
Organisation National Institute for Health Research
Department NIHR Cambridge Biomedical Research Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution I am implementing an approach for deuterium magnetic resonance imaging on the 7T MRI system in Cambridge to trace glucose uptake and metabolism. In this collaboration with Prof Brindle (CRUK-CI) and Dr Mair (Neurosurgery) and others, I am leading the technical development for 7T.
Collaborator Contribution Prof Brindle has extensive experience of DMI in preclinical settings, including in glioblastoma tumour models. Dr Mair brings access to glioblastoma patients undergoing surgery. We plan to perform human studies imminently.
Impact No outputs yet.
Start Year 2018
 
Description GENFI3 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution A new collaboration to exploit the enhanced sensitivity of 7T vs 3T imaging to understand preclinical genetic dementia, in support of early phase trials Expertise in 7T imaging of FTD cohorts
Collaborator Contribution Leadership of the international GENFI consortium into the third phase Expertise on biomarker development
Impact Grant submission underway Pilot work in preparation
Start Year 2020
 
Description JPND EUFIND - European Ultrahigh Field Imaging Biomarkers for Dementia 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. We have contributed expertise, data, and engaged in a pilot study for feasibility and methods development
Collaborator Contribution An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. Our partners from 20 EU sites have contributed expertise, data, and engaged in a pilot study for feasibility and methods development
Impact A project initiation report is submitted to JPND
Start Year 2016
 
Description LC collaboration 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We have engaged with two UCL groups who have a shared interest in noradrenergic systems, and imaging f the locus ceruleus in particular, with data sharing and plans for joint papers.
Collaborator Contribution New sequences and clinical applications of the MR technology
Impact A joint position paper Data sharing
Start Year 2018
 
Description Medical University of Vienna 
Organisation Medical University of Vienna
Country Austria 
Sector Academic/University 
PI Contribution I hosted Prof Albrecht Ingo Schmid for 1 year at my lab in Oxford. We taught him to run cardiac 31P-MRS at 7T. He has now established a group at the Medical University of Vienna working in this area.
Collaborator Contribution Prof Schmid implemented a "STEAM" pulse sequence during his time with us, which we have used to image cardiac intracellular pH for the first time. We have assessed the effects of diabetes and heart failure.
Impact Apps A, Valkovic L, Peterzan M, Lau JYC, Hundertmark M, Clarke WT, Tunnicliffe EM, Ellis J, Tyler DJ, Neubauer S, Rider O, Rodgers CT*, Schmid AI* (joint senior authors). Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers; a 31P MRS study at 7T. Magn Reson Med. In Press. Valkovic L, Clarke WT, Schmid AI, Raman B, Ellis J, Watkins H, Robson MD, Neubauer S, Rodgers CT. Measuring inorganic phosphate and intracellular pH in the healthy and diseased human heart by in vivo 7T 31P-MRS. J Cardiov Magn Reson. DOI: 10.1186/s12968-019-0529-4 PMC 82329 (in progress) ISMRM 2018 abstracts: 53. Schmid AI, Valkovic L, Tunnicliffe EM, Rodgers CT. Unambiguous detection of cardiac Pi using long TM 31P STEAM. Proc. ISMRM 2018 (e-poster). 54. Valkovic L, Batzakis A, Ellis J, Purvis LAB, Schmid AI, Robson MD, Klomp D, Rodgers CT. Whole-body 7T 31P birdcage transmit coil driven by a 35kW RF amplifier with an integrated 30-element 31P receive array and an 8-element 1H transmit/receive array. Proc. ISMRM 2018 (oral). 55. Valkovic L, Schmid AI, Purvis LAB, Ellis J, Neubauer S, Rodgers CT. Quantification of human cardiac inorganic phosphate content in vivo by 31P-MRSI at 7T. Proc. ISMRM 2018 (e-poster). ISMRM 2019 abstracts: 59. Valkovic L, Ellis J, Purvis LAB, Schmid AI, Neubauer S, Rodgers CT. First assessment of cardiac energy metabolism in the lateral and inferior segments of the left ventricle in vivo at 7T. Proc. ISMRM 2019 (power-pitch oral). 61. Choi C-H, Valkovic L, Clarke WT, Schmid AI, Shah NJ, Rodgers CT. NOE enhancement for 31P-MRS of skeletal and cardiac muscle at 7T. Proc. ISMRM 2019 (digital poster). 62. Schmid AI, Apps AP, Valkovic L, Tunnicliffe EM, Clarke WT, Peterzen MA, Neubauer S, Rider OJ, Rodgers CT. Human cardiac pH and Pi concentration during dobutamine stress measured by 7T 31P-MRS. Proc. ISMRM 2019 (digital poster). ISMRM 2020 abstract: 76. Apps A, Lau J, Ellis J, Peterzan M, Hundertmark M, Tyler DJ, Schmid AI, Neubauer S, Oliver Rider, Valkovic L, Rodgers CT. Myocardial Pi/PCr and pH during stress at 7T with STEAM 31P MRS in dilated cardiomyopathy; heart failure beyond the ejection fraction. (power-pitch oral) ISMRM 2021 accepted abstract: 94. Valkovic L, Apps A, Ellis J, Tyler DJ, Neubauer S, Schmid AI, Rider OJ, Rodgers CT. Increased Cardiac Pi in the Diabetic Heart Observed Using STEAM 31P MRS at 7T.
Start Year 2015
 
Description Metabolic imaging in liver EU H2020 "NICI" project 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
PI Contribution Dr Rodgers is the work package leader for data processing. We are leading the integration of this multinuclear metabolic imaging technology on the Siemens platform.
Collaborator Contribution Development of novel whole-body coils for the consortium. Organoid study to target metabolites of interest.
Impact Several abstracts have been submitted to the ISMRM 2019 and 2020 annual meetings. (www.ismrm.org)
Start Year 2018
 
Description Metabolic imaging in liver EU H2020 "NICI" project 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Dr Rodgers is the work package leader for data processing. We are leading the integration of this multinuclear metabolic imaging technology on the Siemens platform.
Collaborator Contribution Development of novel whole-body coils for the consortium. Organoid study to target metabolites of interest.
Impact Several abstracts have been submitted to the ISMRM 2019 and 2020 annual meetings. (www.ismrm.org)
Start Year 2018
 
Description Metabolic imaging in liver EU H2020 "NICI" project 
Organisation University of Pisa
Country Italy 
Sector Academic/University 
PI Contribution Dr Rodgers is the work package leader for data processing. We are leading the integration of this multinuclear metabolic imaging technology on the Siemens platform.
Collaborator Contribution Development of novel whole-body coils for the consortium. Organoid study to target metabolites of interest.
Impact Several abstracts have been submitted to the ISMRM 2019 and 2020 annual meetings. (www.ismrm.org)
Start Year 2018
 
Description NIHR BRC 
Organisation National Institute for Health Research
Department NIHR Cambridge Biomedical Research Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Biomarker development, including cognitive and imaging based deep phenotyping;
Collaborator Contribution Cellular, physiological, radio-chemistry, genetic and pharmaceutical innovations within a pipeline for novel drug discovery;
Impact Adams, N. E., Hughes, L. E., Phillips, H. N., Shaw, A. D., Murley, A. G., Nesbit, D., Cope, T. E., Bevan-Jones, W. R., Passamonti, L., Rowe, J. B. (2020). GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco magnetoencephalography, Journal of Neuroscience, https://doi.org/10.1523/JNEUROSCI.1689-19.2019. Lewis-Smith, D. J., Wolpe, N., Ghosh, B. C. P., Rowe, J. B. (2020). Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia, Journal of Neurology, https://doi.org/10.1007/s00415-019-09672-8. Jabbari, E., Chelban, V., Holland, N., Jones, P. S., Lamb, R., Rawlinson, C., Guo, T., Costantini, A. A., Tan, M. M. X., Heslegrave, A. J., Roncaroli, F., Klein, j. C., Ansorge, O., Allinson, K. S. J., Jaunmuktane, Z., Holton, J. L., Revesz, T., Warner, T. T., Lees, A. J., Zetterberg, H., Russell, L. L., Bocchetta, M., Rohrer, J. D., Williams, N. M., Grosset, D. G., Burn, D. J., Pavese, N., Gerhard, A., Kobylecki, C., Leigh, P. G., Church, A., Hu, M. T. M., Woodside, J., Houlden, H., Rowe, J. B., Morris, H. R. (2020). Diagnosis across the spectrum of progressive supranuclear palsy and corticobasal syndrome, JAMA Neurology, doi:10.1001/jamaneurol.2019.4347. van der Ende, E. L,, Meeter, L. H., Poos, J. M., Panman, J. L., Jiskoot, L. C., Dopper, E. G. P., Papma, J. M., de Jong, F. J., Verberk, I., Teunissen, C. E., Rizopoulos, D., Heller, C., Convery, R. S., Moore, K. M., Bocchetta, M., Neason, M., Cash, D. M., Borroni, B., Galimberti, D., Sanchez-Valle, R., Laforce, Jr R., Moreno, F., Synofzik, M., Graff, C., Masellis, M., Tartaglia, M. C., Rowe, J. B., Vandenberghe, R., Finger, E., Tagliavini, F., de Mendonça, A., Santana, I., Butler, C., Ducharme, S., Gerhard, A., Danek, A., Levin, J., Otto, M., Frisoni, G. B., Cappa, S., Pijnenburg, Y. A. L., on behalf of the GENetic Frontotemporal Dementia Initiative (GENFI), Rohrer, J. D., van Swieten, J. C. (2019). Longitudinal serum neurofilament light chain in genetic frontotemporal dementia: a multicentre cohort study. Lancet Neurology, 18: 1103-1111, https://doi.org/10.1016/S1474-4422(19)30354-0. Shafto, M. A., Henson, R. N., Matthews, F. E., Taylor, J. R., Emery, T., Erzinclioglu, S., Hanley, C., Rowe, J. B., Cusack, R., Calder, A. J., Marslen-Wilson, W. D., Duncan, J., Dalgleish, T., Brayne, C., Cam-CAN, Tyler, L. K. (2019). Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project, Journal of Aging and Health, doi: 10.1177/0898264319878095 [ahead of print], PMID: 31592706 Lansdall, C. J., Coyle-Gilchrist, I. T. S., Vázquez Rodríguez, P., Wilcox, A., Wehmann, E., Robbins, T. W., Rowe, J. B. (2019). Prognostic importance of apathy in syndromes associated with Frontotemporal lobar Degeneration, Neurology, 92(14):e1547-e1557. doi: 10.1212/WNL.0000000000007249, PMID: 30842292, PMC: 6448451. Borchert, B. J., Rittman, T., Rae, C. L., Passamonti, L., Jones, P. S., Vatansever, D., Vazquez-Rodriguez, P., Ye, Z., Nombela, C., Hughes, L. E., Robbins, T. W., Rowe, J. B. (2019). Atomoxetine and citalopram alter brain network organization in Parkinson's disease, Brain Communications, 1:1 fcz013, https://doi.org/10.1093/braincomms/fcz013. PMID: [pending], PMC: [pending]. Nicastro, N., Surendranathan, A., Mak, E., Rowe, J. B.*, O'Brien, J. T.* (2019). 11C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia, Annals of Clinical and Translational Neurology, doi: 10.1002/acn3.50877, PMID: 31507085, PMC: [pending]. Low, A., Mak, E., Malpetti, M., Chouliaras, L., Nicastro, N., Su, L., Holland, N., Rittman, T., Vázquez Rodríguez, P., Passamonti, L., Bevan-Jones, W. R., Jones, P. S., Rowe, J. B.*, O'Brien, J. T.* (2019). Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features, Alzheimer's & Dementia: Diagnosis, Assessment, & Disease Monitoring, 11: 690-699, DOI: https://doi.org/10.1016/j.dadm.2019.08.001, PMID: 31667328, PMC: 6811895. Tavares, T. P., Mitchell, D. G. V., Coleman, K., Shoesmith, C., Bartha, R., Cash, D. M., Moore, K. M., van Swieten, J. C., Borroni, B., Galimberti, D., Tartaglia, M. C., Rowe, J. B., Graff, C., Tagliavini, F., Frisoni, G., Cappa, S., Laforce, R. Jr, de Mendonça, A., Sorbi, S., Wallstrom, G., Masellis, M., Rohrer, J. D., Finger, E. C., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Ventricular volume expansion in presymptomatic genetic frontotemporal dementia, Neurology, doi: 10.1212/WNL.0000000000008386, PMID: 31578297, PMC: [pending]. Passamonti, L., Tsvetanov, K. A., Jones, P. S., Bevan-Jones, W. R., Arnold, R., Borchert, R. J., Mak, E., Su, L., O'Brien, J. T.*, Rowe, J. B.* (2019). Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2574-18.2019. PMID: 31320450, PMC: 6733539. Jabbari, E., Woodside, J., Guo, T., Magdalinou, N. K., Chelban, V., Athauda, D., Lees, A. J., Foltynie, T., Houlden, H., Church, A., Hu, M. T., Rowe, J. B., Zetterberg, H., Morris, H. R. (2019). Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes, Journal of Neurology, Neurosurgery and Psychiatry, 90(7):768-773. doi: 10.1136/jnnp-2018-320151. PMID: 30867224, PMC: 6585258. Hughes, L. E., Henson, R. N., Pereda, E., Bruña, R., López-Sanz, D., Quinn, A. J., Woolrich, M. W., Nobre, A. C., Rowe, J. B., Maestú, F., BioFIND Working Group (2019). Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography, Alzheimers & Dementia (Amsterdam, Netherlands), 11:450-462. doi: 10.1016/j.dadm.2019.04.009. PMID: 31431918, PMC: 6579903. Shaw, A. D., Hughes, L. E., Moran, R., Coyle-Gilchrist, I., Rittman, T., Rowe, J. B. (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies. Cerebral Cortex. 2019. doi: 10.1093/cercor/bhz024. PMID: 31216360. van Eimeren, T., Antonini, A., Berg, D., Bohnen, N., Ceravolo, R., Drzezga, A., Höglinger, G. U., Higuchi, M., Lehericy, S., Lewis, S., Monchi, O., Nestor, P., Ondrus, M., Pavese, N., Peralta, M.C., Piccini, P., Pineda-Pardo, J. Á., Rektorová, I., Rodríguez-Oroz, M., Rominger, A., Seppi, K., Stoessl, A. J., Tessitore, A., Thobois, S., Kaasinen, V., Wenning, G., Siebner, H. R., Strafella, A. P., Rowe, J. B. (2019). Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimers & Dementia (Amsterdam, Netherlands). 11:301-309. doi: 10.1016/j.dadm.2019.01.011. PMID: 30984816, PMC: 6446052. Rittman, T., Borchert, R., Jones, P. S., van Swieten, J., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Graff, C., Tagliavini, F., Frisoni, G. B., Laforce, R. Jr, Finger, E., Mendonça, A., Sorbi, S., Rohrer, J. D., Rowe, J. B., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia, Neurobioly of Aging, 77:169-177. doi: 10.1016/j.neurobiolaging.2018.12.009, PMID: 30831384; PMC: 6491498. Bevan-Jones, W. R., Cope, T. E., Jones, P. S., Passamonti, L., Hong, Y. T., Fryer, T., Arnold, R., Coles, J. P., Aigbirhio, F. I., O'Brien, J. T., Rowe, J. B. (2019). In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier. Annals of Clinical Translational Neurology, 6(2):373-378. doi: 10.1002/acn3.683. PMID: 30847369; PMC: 6389753.
Start Year 2017
 
Description PREVENT 7T 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Application of 7T technology to understand the effects of inherited risk of dementia
Collaborator Contribution Coordination of national PREVENT study of people at risk of dementia
Impact Pending
Start Year 2019
 
Description Paragraf 
Organisation Paragraf Limited
Country United Kingdom 
Sector Private 
PI Contribution Paragraph developed very sensitive magnetic field sensors based on graphene. Our work together focuses on application of the magnetic field sensors in Ultra High Field MRI in order to deliver precise characteristic of both static and time dependent (generated by the gradient coils) magnetic fields used in MRI scanners. The characterization includes measurements of timing, magnitude and orientation of the magnetic field in various points in space during the imaging. The study aims to validate the sensors' compatibility with the scanner and utilize the obtained field characteristic in order to improve quality of MR imaging. A Non Disclosure Agreement has been put in place and experiments with the sensors has been planned but were interrupted by COVID19.
Collaborator Contribution Paragraph developed very sensitive magnetic field sensors based on graphene. They are providing these on loan for us to assess in an MRI environment. They could provide a new tool to correct image inhomogeneity caused by gradient imperfections or form the basis of a motion sensor.
Impact None yet.
Start Year 2020
 
Description Parallel transmit workshop collaboration 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution We hosted Ed Pracht from DZNE to learn hands-on parallel transmit programming. We have subsequently joined forces with his group at DZNE and Siemens to run our first parallel transmit 7T MRI workshop with 61 delegates from across Europe. These will now continue quarterly.
Collaborator Contribution We hosted Dr Pracht in Cambridge. We hosted the first parallel transmit workshop on MS Teams.
Impact Outputs will follow. This is community building at this stage.
Start Year 2020
 
Description Siemens collaboration 
Organisation Siemens Healthcare
Country Germany 
Sector Private 
PI Contribution In establishing the new 7T MRI Research Facility, we have actively enganged with Siemens to revise and optimise the facility on an accelarated timescale. We will be the first non-Germany site to test their new Terra System, and to apply Terra to dementia and neuroscience disciplines.
Collaborator Contribution ?810,000 budgetary revision and 'no-cost' like-for-like upgrade of core technologies of circa ?750,000. Fellowship, on-site engineer for 12months and Scientist for 18 months circa ?260,000. So, total Siemens contribution ~?1,820,000. Subsequent substantial in kind contribution negotiated
Impact Delivery on time and on budget of new facility in 2016. Since 2017: Standard sequences are in in place with good QC/QA, and the scanner is in use for several research studies in clinical populations, ageing and development. The scanner is booked >80% now for clinical and cognitive neuroscience studies. We have negotiated research agreements with Siemens for 4 areas of collaborative development in MRI physics at 7T with the 7T physics group. These include developments in parallel transmit methods in the brain and body; developments in MR spectroscopy; and developments in whole-body metabolic imaging at 7T.
Start Year 2015
 
Description UK 7T MRI network 
Organisation Cardiff University
Department Brain Research Imaging Centre (CUBRIC)
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Glasgow
Department Institute of Neuroscience and Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Nottingham
Department School of Biomedical Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Oxford
Department Oxford Centre for Functional MRI of the Brain (FMRIB)
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards.
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description Ultrahigh resolution imaging of neurodegeneration and vascular risk in aging and preclinical and prodromal Alzheimer's Disease 
Organisation The Otto-von-Guericke University Magdeburg
Country Germany 
Sector Academic/University 
PI Contribution New consortium to faciliate and validate 7T in dementia research, across 15 EU sites. Meets and draft preparation
Collaborator Contribution Led by Prof Duzel, Magdeburg, a consortium building on EUFIND.
Impact None yet. Funding sought
Start Year 2019
 
Title Atomoxetine in PSP 
Description new drug strategy for impulsivity in PSP to be tested for first time. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Under active development/distribution
Clinical Trial? Yes
Impact reduced impulsivity in selected patients 
 
Title Biomarker evaluation of 7T MRI in dementia 
Description evaluation of novel 7T MRI for early detection of pathology in AD, and other dementias, building on the JPND consortium "EUFIND" 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2020
Development Status Under active development/distribution
Impact stronger links to basic cognitive neurosciences of memory systems, and to multi-centre clinical transnational centres across EU 
 
Title Tiagabine in FTLD 
Description New drug strategy for impulsivity in FTLD tested for first time. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2021
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Reduced impulsivity in selected patients. 
 
Title Novel MRI pulse sequences for imaging and spectroscopy in vivo 
Description We have published abstracts describing novel imaging and spectroscopy pulse sequences at the ISMRM 2019 and 2020 annual meetings. Particular focus areas include: neuromelanin imaging (by MT sensitised MRI), FatNav motion correction with reconstruction in an open source tool, multinuclear spectroscopy tools for the 7T Terra platform. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2019 
Impact These methods are now being used in studies in Cambridge. Dr Pracht from DZNE Bonn visited us in Jan 2020 to learn more about our parallel transmit implementations on the 7T Terra. 
 
Description (Dr Rua) ISMRM 2020 - In-vivo characterization of the biochemical properties of the locus coeruleus and substantia nigra in healthy controls and Parkinson's disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact n/a
Year(s) Of Engagement Activity 2020
URL https://archive.ismrm.org/2020/1532.html
 
Description (Dr Rua) ISMRM 2020 - Initial experience on 7T Terra for human parallel transmit (pTx) liver imaging 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact n/a
Year(s) Of Engagement Activity 2020
URL https://archive.ismrm.org/2020/4288.html
 
Description (Dr Rua) ISMRM 2020 - Investigation of pTx pulses for magnetisation inversion on 7T Terra 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact n/a
Year(s) Of Engagement Activity 2020
URL https://archive.ismrm.org/2020/4276.html
 
Description (Dr Rua) ISMRM 2020 - Layer-dependent Transient Saturation Transfer MRI at 7T 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact n/a
Year(s) Of Engagement Activity 2020
URL https://archive.ismrm.org/2020/3112.html
 
Description (Dr Rua) ISMRM 2020 - Parallel transmit (pTx) with online pulse design for task-based fMRI at 7T 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact n/a
Year(s) Of Engagement Activity 2020
URL https://www.ismrm.org/20/program_files/DP11-02.htm
 
Description (Prof Kourtzi) Talk at 25th Annual Meeting of the Organization for Human Brain Mapping, Rome, Italy (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Ultra-high field fMRI reveals cortical depth specificity for adaptation in the human
visual cortex. 2019. Elisa Zamboni, Valentin G. Kemper, Nuno R. Goncalves, Ke
Jia, Rainer Goebel and Zoe Kourtzi, 25th Annual Meeting of the Organization for
Human Brain Mapping, Rome, Italy.
Year(s) Of Engagement Activity 2019
 
Description (Prof Kourtzi) Vision Sciences Society, St Petersburg, Florida, USA 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Ultra-high field imaging of perceptual learning in the human visual cortex. 2019.
Ke Jia, Elisa Zamboni, Nuno Reis Goncalves, Catarina Rua, Valentin Kemper,
Guy Williams, Chris Rodgers and Zoe Kourtzi, Vision Sciences Society, St
Petersburg, Florida, USA.
Year(s) Of Engagement Activity 2019
 
Description 23rd National Dementia Conference: Talk on "Frontotemporal Dementia" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact An update on FTD landscape and research output from Rowe group.
Year(s) Of Engagement Activity 2021
 
Description ARUK Clinical Conference. talk titled "What's new in Frontotemporal Dementia?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This conference focussed on the themes of research, innovation, and implementing change in clinical practice.
Year(s) Of Engagement Activity 2021
 
Description Article about our research in AuntMinnie trade magazine 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Our study in COVID patients was covered by the AuntMinnie.com trade magazine.
Year(s) Of Engagement Activity 2021
 
Description Brain Conference, talk given on "Apathy and Impulsivity" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation during cognition and dementia theme of Brain conference 2021.
Year(s) Of Engagement Activity 2021
 
Description British Neuropathological Society meeting, Cirencester, UK 3-5 July 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Attended by Dr Luca Passamonti and Dr Sanne Kaalund to strenghten their network in neuropathology research.
Year(s) Of Engagement Activity 2019
URL https://www.bns.org.uk/wp-content/uploads/2018/12/Programme_BNSSummerSchool2019.pdf
 
Description CBU Methods Day training workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Training in MRI methods for the Cambridge community
Year(s) Of Engagement Activity 2022
 
Description CCPP patient liaison 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact A patient liaison group, to advise and feedback on experience of research participation, and future studies' documentation.
Year(s) Of Engagement Activity 2018,2019
 
Description Cambridge Imaging Festival, Cambridge 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dr Luca Passamonti presented a talk titled: Integrative brain imaging to understand and treat dementia.
Year(s) Of Engagement Activity 2019
URL https://radiology.medschl.cam.ac.uk/wp-content/uploads/2019/05/CIF-Programme-with-link.pdf
 
Description Cambridge Neuroscience Postdoc Symposium, University of Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Showcasing research outputs on 7T imaging of Locus Coeruleus in neurodegenerative disease by Dr Rong Ye.
Year(s) Of Engagement Activity 2019
 
Description Chris Rodgers - 7T seminar & ISMRM Nordic Chapter meeting, Norway 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk at combined 7T seminar & ISMRM Nordic Chapter meeting, Norway
Year(s) Of Engagement Activity 2018
 
Description Chris Rodgers - Biennial Minnesota MRI workshop, Minneapolis, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk at the 12th Biennial Minnesota MRI workshop, Minneapolis, USA, one of the worlds leading events for advanced imaging researchers. An opportunity to showcase the progress made under this grant.
Year(s) Of Engagement Activity 2019
 
Description Chris Rodgers - British Chapter ISMRM Annual Meeting, Oxford, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk at the British Chapter of ISMRM Annual Meeting, Oxford, UK.
Year(s) Of Engagement Activity 2018
 
Description Chris Rodgers - ISMRM Ultra-high field workshop 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The 2019 ISMRM Ultra-high Field Workshop, Croatia, to deliver an invited talk. The ISMRM is the principal international organisation for MRI research, and this meeting is dedicated to UHF imaging, including the showcasing of developments made during my Sir Henry Dale Fellowship and its extension.
Year(s) Of Engagement Activity 2019
 
Description Dr M Malpetti - Host of Clinical Neurosciences Seminar & Conversation with Prof. JB Rowe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Discussion on "From mechanisms to treatment, in disorders of frontotemporal lobar degeneration."
Year(s) Of Engagement Activity 2021
 
Description Dr Maura Malpetti - ROWE GROUP MEMBER Invited speaker at Alzheimer's Association International Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Invited as a speaker on Brain inflammation in frontotemporal dementia. ISTAART conversation with patients and carers.
Year(s) Of Engagement Activity 2021
 
Description Dr Maura Malpetti - ROWE GROUP MEMBER Organizing committee member "My memory clinic and me" Cambridge Festival 2021 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact My memory clinic and me" at Cambridge Festival 2021 - a session held for those interested in neurodegenerative diseases.
Year(s) Of Engagement Activity 2021
URL https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d
 
Description Expert review panel for magnetic resonance spectroscopy at the ISMRM Annual Meeting 2020 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I participated as one of four panel members giving an expert summary and review of presentations at the ISMRM's 2020 Annual Meeting. Our review covered developments in magnetic resonance spectroscopy. We maximised our zoom online session attendee limit for a one hour discussion.
Year(s) Of Engagement Activity 2020
URL https://www.ismrm.org/20m/
 
Description Imaging the Locus Coeruleus with Ultra-high 7T MRI - DRCMR Copenhagen, Denmark 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The purpose of the workshop was to communicate research outputs generated by Prof James Rowe's group to Danish future collaborators, particularly by Dr Rong Ye and Dr Catarina Rua (both specialising in 7T imaging) and the use of 7T in neurodegenerative disease. The main outcome of this newly forged collaboration was to provide analysis pipeline advice to Danish group.
Year(s) Of Engagement Activity 2019
 
Description International Congress of Parkinson's Disease and Movement Disorders - Nice 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Advances in PSP and its overlap with FTD, main meeting and satellite symposia on PSP and Brain Imaging
Year(s) Of Engagement Activity 2019
URL https://www.mdscongress.org/Congress-Branded/19FP-_blue_puzzle_online.pdf
 
Description Invited lecture at ultra-high field study group symposium at the ISMRM Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was invited to survey the areas of opportunity for ultra-high field imaging in the human heart. This lecture should have been delivered in Sydney in Apr 2020 but was postponed due to COVID19. It is now scheduled for the forthcoming meeting in May 2021.
Year(s) Of Engagement Activity 2021
URL https://www.ismrm.org/21m/
 
Description Invited session chair at Alzheimer's Association International Conference 2021, USA - Dr M Malpetti 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session on "Neuroimaging: Molecular Imaging of Novel Biomarkers for Neurodegeneration and ADRD" session at AAIC 2021 (07/2021 - Denver USA)
Year(s) Of Engagement Activity 2021
 
Description Invited speaker at 7TMRI group University of Cambridge- Dr Amirhossein Jafarian 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Title: Prior in DCM and MRS informed dynamic causal modelling.
Year(s) Of Engagement Activity 2021
 
Description Locus Coeruleus Imaging Meeting Magdeburg 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This workshop was attended by Dr Luca Passamonti, Dr Sanne Kaalund, Dr Rong Ye and Dr Catarina Rua. The team were showcasing research in LC and the use of 7T.

At this years LC meeting, we aim to focus on the following questions:

1. How can we improve structural / functional / PET LC imaging?

2. What is the role and fate of the LC in neurodegenerative and clinical conditions? What renders the LC particularly vulnerable?

3. What have we learned (also from animal research) on the LCs role in cognition and behavior in the last years?

4. What are the most promising interventions targeting the LC / NA system?

We will post a detailed program on the website and send it via email to all registered users at a later date. Please see information on our previous meeting held last February and the resultant consensus paper summarizing how LC imaging can be used for clinical research in neurodegenerative diseases.

New for this years meeting are 1-2 methods workshops for those interested:

A two day hackathon (Saturday 14th and Sunday 15th) where MR physicists will do some hands-on tests to explore new imaging approaches (this will be mostly relevant for MR physicists doing LC imaging)
If there is enough interest, an extra session on LC methods in animal research (electrophysiology, high-field imaging, optogenetics, ...) which will take place on Saturday 14th. Please let us know if you would like to join either of these!
Year(s) Of Engagement Activity 2019
URL http://www.iknd.ovgu.de/LC+Meeting+2019.html
 
Description MEGUK Oral Presentation by Dr Amirhossein Jafarian (Rowe Group) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Gave an oral presentation titled Multimodal Dynamic causal modelling
Year(s) Of Engagement Activity 2021
 
Description MRC CBU Science Night - Cambridge Science Festival 2019 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Demonstrations of research studies, including VR game
Year(s) Of Engagement Activity 2019
URL http://www.mrc-cbu.cam.ac.uk/blog/2019/01/mrc-cbu-science-night-cambridge-science-festival-2019/
 
Description MRI motion correction - invited talk at KBFI CoE EQUiTANT seminar, Tallinn, Estonia - Dec. 2020 by Dr Klodowski 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Klodowski from my research group gave this invited talk.
Year(s) Of Engagement Activity 2020
 
Description My Memory Clinic and Me 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presented at an event titled My Memory Clinic and Me as part of the Cambridge Festival in March 2021. The Cambridge Memory Clinic provides assessment and management for a wide range of memory and cognitive disorders, for example, due to neurodegeneration (Alzheimer's disease, Mild Cognitive Impairment, Frontotemporal dementia, Dementia with Lewy Bodies) and more. A discussion was help about memory clinics in the context of dementia. How they can help, and what to expect - including their role in leading research that matters to patient care. Short presentations followed by a live Q&A session with consultant neurologists.
Year(s) Of Engagement Activity 2021
URL https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d
 
Description National Advertising Campaign with Alzheimer's Research UK 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact National advertising campaign
Year(s) Of Engagement Activity 2021,2022
 
Description OLS/UKRI cross sector specialist workshop/committee for new national dementia initiative strategy for 2022 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Meeting with No.10 officials on UK Dementia landscape.
Year(s) Of Engagement Activity 2021,2022
 
Description Organisation of Human Brain Mappinh annual meeting, Rome 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research outputs stemming from analyses conducted by Dr Rong Ye at the Clinical Neurosciences department (supervisor Prof James Rowe). The presentation was part of the symposium on neurodegenerative and vascular disorders and how 7T can improve the clinical research in this area.
Year(s) Of Engagement Activity 2019
URL https://www.pathlms.com/ohbm/courses/12238/sections/15845/video_presentations/138100
 
Description PPE - Cambridge university Hospitals Trust members 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact An evening event for the members of the Trust (patients, and local public) to discuss advances in dementia research and care, including the insights from new technologies
Year(s) Of Engagement Activity 2019
 
Description Powerpitch on parallel transmit ultra-high field MRI at the EUFIND meeting at the DZNE, Bonn 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I presented our recent work on ultra-high field parallel transmit functional imaging and a proposal for the future EUFIND consortium funding bid to include parallel transmit aspects.
Year(s) Of Engagement Activity 2020
 
Description Presentation and interview for Y12 student open day at Peterhouse (HE+ Visit) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact I gave a presentation and then answered questions on research, undergraduate teaching and university life from a group of Y12 students visiting Cambridge as part of the HE+ Visit scheme.
Year(s) Of Engagement Activity 2019
 
Description Prof J B Rowe: "Restoring brain function in dementia", Beacon workshop, University of Nottingham (12th April '19) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Restoring brain function in dementia @ Nottingham Beacon workshop Beacon workshop on sensorimotor brain oscillations #914915804 When: 12 April 2019
Year(s) Of Engagement Activity 2019
 
Description Prof J B Rowe: EUFIND Bonn 7T meeting talk: "Neurochemistry of frontotemporal lobar degeneration: frontotemporal dementia and progressive supranuclear palsy" (30th Jan '20) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 30th January Bonn EUFIN meeting for 7T - Neurochemistry of frontotemporal lobar degeneration: frontotemporal dementia and progressive supranuclear palsy
Year(s) Of Engagement Activity 2020
 
Description Prof J B Rowe: Magdeburg/DZNE Locus Coeruleus "Noradrenergic deficit and restoration in Progressive Supranuclear Palsy" (12th Dec '19) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 12th Dec Magdeburg/DZNE LC meeting - "Noradrenergic deficit and restoration in Progressive Supranuclear Palsy
Year(s) Of Engagement Activity 2019
 
Description Public lecture at Institution of Engineering and Technology Cambridge group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Gave invited evening lecture at the Institution of Engineering and Technology's Cambridge local group.
Year(s) Of Engagement Activity 2020
URL https://communities.theiet.org/communities/events/item/229/77/23208
 
Description Rittmann, T. (14th May 2018). The story of a noisy brain. Pint of Science, Annual Science Festival, Castle Bar, Cambridge, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Increase awareness. Discuss science with general public
Year(s) Of Engagement Activity 2018
 
Description Rowe - BBC Look East (2016) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 7T for dementia research
Year(s) Of Engagement Activity 2016
 
Description Rowe - Cambridge Science Festival (2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Lecture at Cambridge Science Festival
Year(s) Of Engagement Activity 2017
 
Description Rowe - Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. University of Cambridge News for Medical Design Technology (2016) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (24th October 2016). Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. University of Cambridge News for Medical Design Technology. http://www.cam.ac.uk/research/news/cambridge-extends-world-leading-role-for-medical-imaging-with-powerful-new-brain-and-body-scanners
Year(s) Of Engagement Activity 2016
URL http://www.cam.ac.uk/research/news/cambridge-extends-world-leading-role-for-medical-imaging-with-pow...
 
Description Rowe - FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge (2017). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (13th September 2017). FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge; give feedback to carers and also get feedback from them.
Year(s) Of Engagement Activity 2017
 
Description Rowe - FTD-UK Annual Meeting (2017) - Debate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A discussion of imaging's contribution to FTD diagnosis, prognosis and stratification
Year(s) Of Engagement Activity 2017
 
Description Rowe - First dementia patient is scanned. BRC Communications, R D Newsletter, Cambridge Biomedical Research Centre (2017) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Rowe, J. B. (6th October 2017). First dementia patient is scanned. BRC Communications, R&D Newsletter, Cambridge Biomedical Research Centre.
Year(s) Of Engagement Activity 2017
 
Description Rowe - For the Dementia Awareness Week: Professor James Rowe of @CamNeuro on Cambridge s role in dementia research. University of Cambridge, (2017). 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Rowe, J. B. (17th May 2017). For the Dementia Awareness Week: Professor James Rowe of @CamNeuro on #Cambridge's role in dementia research. University of Cambridge, Cambridge TV @cambridgetvnews (Twitter Video).
https://twitter.com/cambridgetvnews/status/864790164861800448; awareness for dementia
Year(s) Of Engagement Activity 2017
URL http://twitter.com/cambridgetvnews/status/864790164861800448
 
Description Rowe - Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association) (2017) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rowe, J. B. (16th May 2017). Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association).
Year(s) Of Engagement Activity 2017
 
Description Rowe Group Member Dr NEGIN HOLLAND gave talk: Synaptic imaging in dementia and neurodegenerative disease @ Cambridge Imaging Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact This is a meeting of users and experts within the Cambridge NHS and academic community. Results and data are shared as well as new perspectives and applications for novel imaging methods.
Year(s) Of Engagement Activity 2021
URL https://www.mrc-cbu.cam.ac.uk/wp-content/uploads/2021/05/Programme-Cambridge-Imaging-Festival-2021.p...
 
Description Rowe/Team - Cambridge Science Festival (2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A lecture on the challenge of dementia as part of the Cambridge Science Festival
Year(s) Of Engagement Activity 2017
 
Description Session Chair: Cognition at Brain 2022 Conference 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session on congnition with research presentations on:
1. Transdiagnostic approaches to cognitive disorders and their underlying brain
pathology
2. Dissociable brain microstructural diffusivity changes underlying visual short
-term memory deficits in Alzheimer's disease.
3. Bayesian Brains and the origin of functional disorders.
4. 'Socioeconomic status impacts cognitive and socioemotional processes in healthy
ageing: evidence from Latin American older adults.
5. Noradrenergic treatment of cognitive disorders: big news from the blue spot.
Year(s) Of Engagement Activity 2022
URL https://thebrainconference.co.uk/brain-conference-schedule/
 
Description Sir Peter Mansfield Imaging Centre, Nottingham 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited seminar at the Sir Peter Mansfield Imaging Centre, Nottingham
Year(s) Of Engagement Activity 2019
 
Description Specialist PSP Sub-group @ Movement Disorder Society International Conference: UHF 7T Imaging 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Expert panel meeting on imaging and Progressive supranuclear palsy.
Year(s) Of Engagement Activity 2021
 
Description Talk at - Alzheimer's Association International Conference 2021, Dr Maura Malpetti 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia" - Alzheimer's Association International Conference
Year(s) Of Engagement Activity 2021
 
Description Talk by Dr M Malpetti at (ISTAART) Scientific Meeting: What have we learnt from PET in FTD in the last 10 years? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "What have we learnt from PET in FTD in the last 10 years" - ISTAART FTD and Neuroimaging PIAs webinar: An update on neuroimaging in frontotemporal dementia (virtual event)
Year(s) Of Engagement Activity 2021
 
Description Talk by Dr M Malpetti at Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Scientific Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk title: Neuroinflammation in medial temporal regions predicts cognitive decline in dementia with Lewy bodies
Year(s) Of Engagement Activity 2021
 
Description Talk by Dr M Malpetti at Clinical Neurosciences Away Day, Cambridge University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk title: Neuroinflammation in frontotemporal lobar degeneration: a target for treatment?
Year(s) Of Engagement Activity 2021
 
Description The Dementia UK Ecosystem and Innovations in biomarkers @ Cambridge Memory Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The aim of this Cambridge-wide memory group is to encourage interaction between the many local labs working on the psychology/neuroscience of short- and long-term memory, both human and non-human. The talk given to this audience gave an overview of the key UK institutions and partners involved in dementia research aimed at identifying new biomarkers for plausibale clinical translation.
Year(s) Of Engagement Activity 2021
URL http://www.memlab.psychol.cam.ac.uk/CAMM/index.html
 
Description Tim Sandhu Talk @ CamBrain Cambridge Neuroscience Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Oral presentation to junior researchers or those interested in neuroscience.
Year(s) Of Engagement Activity 2021
 
Description Voice of Islam - Dementia 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Discussion on voice of islam broadcast on the theme of dementia to raise public awareness, especially within the Muslim community.
Year(s) Of Engagement Activity 2022
 
Description Voice of Islam Radio - Dementia Theme 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Voice of Islam broadcast discussion on dementia.
Year(s) Of Engagement Activity 2021
 
Description WBIC presentation at Physics at Work - Sep. 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Dr Klodowski from my group presented in the Physics at Work outreach event.
Year(s) Of Engagement Activity 2020
 
Description Year 12 student taster 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact A "taster lecture" to 6th form students visiting Cambridge on an outreach visit. For students in the Biology / Chemistry / Medicine stream, promoting accessibility and engagement with University applications in STEM.
Year(s) Of Engagement Activity 2019