A new collaborative ultra-high field MRI facility for dementia and neuroscience research
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Neurosciences
Abstract
Magnetic Resonance Imaging (MRI) has revolutionised the study of the brain and brain diseases like dementia over the last 20 years. Conventional MRI scanners have their limitations however. We will therefore build an "ultrahigh-field" MRI, which offers a major step forward in how clearly one can study the brain's structure, function and chemistry. This new scanner will be dedicated to the challenge of dementia, supported by scientific work to understand the normal brain and advanced analysis. It will be a major contributor to the UK Dementia Platform, a unique and radical approach to join up medical research across the country's specialist centres and drug company partners in the fight against dementia.
The new "7T" scanner will be built on the Cambridge Biomedical Campus, next to Addenbrookes Hospital. It is a collaboration between Cambridge University and the Medical Research Council's Cognition and Brain Sciences Unit (CBSU), working closely with the NHS. We will use the new scanner to detect and characterise over time the major brain diseases like Alzheimer's, Stroke and Parkinson's Disease.
With our ageing population, the number of people suffering from dementia is likely to increase from the current level of 800,000. The need is urgent to identify people in the earliest stages of such diseases, or even before symptoms, in order to test treatments that combat dementia. Cambridge is ideally suited for this research, because of i) its existing expertise in dementia and MRI brain scanning, ii) its key role in national initiatives to understand dementia and the healthy ageing process, iii) its collaborations with major pharmaceutical companies to develop new treatments, and iv) the existence of large cohort studies that track normal ageing over decades, and groups of research volunteers who, because of genetics or lifestyle, are at-risk of dementia.
MRI is a very versatile technology. MRI scanners can be "tuned" to measure the grey matter (home to most of the brain cells), white matter (the wiring of the brain), the major chemicals in the brain and microscopic effects of dementia. MRI can also measure brain function, allowing researchers to map the brain areas needed for attention, memory or language. The new scanner gives much greater detail across the entire brain, allowing researchers to understand how the brain works as a whole while still seeing detail at a sub-millimetre scale. This detail is important for diseases like Alzheimer's and Parkinson's, for which small and deep parts of the brainstem are critical but difficult to see with conventional MRI.
Moreover, the increased detail offered by ultrahigh field MRI opens the window on an important level of organisation in the brain: the thin layers of the surface of the brain, which have until recently only been studied with invasive recordings. With the new scanner, we can safely study this fundamental level of brain organisation in humans. This will accelerate our scientific understanding of the basic workings of the brain. This draws on the very large community of brain researchers in Cambridge, to investigate, for example, the i) brain changes that put some people at risk of addiction, ii) brain networks linked to obesity, iii) how the brain normally ages, and why some people are resilient as they get older, and iv) how the brain matures through teenage years, when major mental illness like schizophrenia normally begin. Other medical researchers will use the scanner to understand i) recovery of the brain after head injury, ii) the brain systems implicated in pain, and iii) stroke and other disorders associated with impairments in the brain's blood supply.
The depth and breadth of brain research is why the University of Cambridge and partners are planning to join together with the Medical Research Council to invest in this breakthrough technology. The ultrahigh-field MRI will advance both basic and medical research, to improve the health of the nation.
The new "7T" scanner will be built on the Cambridge Biomedical Campus, next to Addenbrookes Hospital. It is a collaboration between Cambridge University and the Medical Research Council's Cognition and Brain Sciences Unit (CBSU), working closely with the NHS. We will use the new scanner to detect and characterise over time the major brain diseases like Alzheimer's, Stroke and Parkinson's Disease.
With our ageing population, the number of people suffering from dementia is likely to increase from the current level of 800,000. The need is urgent to identify people in the earliest stages of such diseases, or even before symptoms, in order to test treatments that combat dementia. Cambridge is ideally suited for this research, because of i) its existing expertise in dementia and MRI brain scanning, ii) its key role in national initiatives to understand dementia and the healthy ageing process, iii) its collaborations with major pharmaceutical companies to develop new treatments, and iv) the existence of large cohort studies that track normal ageing over decades, and groups of research volunteers who, because of genetics or lifestyle, are at-risk of dementia.
MRI is a very versatile technology. MRI scanners can be "tuned" to measure the grey matter (home to most of the brain cells), white matter (the wiring of the brain), the major chemicals in the brain and microscopic effects of dementia. MRI can also measure brain function, allowing researchers to map the brain areas needed for attention, memory or language. The new scanner gives much greater detail across the entire brain, allowing researchers to understand how the brain works as a whole while still seeing detail at a sub-millimetre scale. This detail is important for diseases like Alzheimer's and Parkinson's, for which small and deep parts of the brainstem are critical but difficult to see with conventional MRI.
Moreover, the increased detail offered by ultrahigh field MRI opens the window on an important level of organisation in the brain: the thin layers of the surface of the brain, which have until recently only been studied with invasive recordings. With the new scanner, we can safely study this fundamental level of brain organisation in humans. This will accelerate our scientific understanding of the basic workings of the brain. This draws on the very large community of brain researchers in Cambridge, to investigate, for example, the i) brain changes that put some people at risk of addiction, ii) brain networks linked to obesity, iii) how the brain normally ages, and why some people are resilient as they get older, and iv) how the brain matures through teenage years, when major mental illness like schizophrenia normally begin. Other medical researchers will use the scanner to understand i) recovery of the brain after head injury, ii) the brain systems implicated in pain, and iii) stroke and other disorders associated with impairments in the brain's blood supply.
The depth and breadth of brain research is why the University of Cambridge and partners are planning to join together with the Medical Research Council to invest in this breakthrough technology. The ultrahigh-field MRI will advance both basic and medical research, to improve the health of the nation.
Technical Summary
The resolution of 7T MRI will be used to study the pathogenesis of dementia, mechanisms of resilience, and response to therapy in terms of structure (volumetric and diffusion weighted), function (BOLD) and spectroscopy. Sensitivity to iron deposition by quantitative susceptibility mapping is especially relevant to Alzheimer's disease, while structural and functional changes in vasculature will be examined as markers and targets in stoke, dementia and Huntington's disease. We will delineate the aetiological role of small but critical subcortical structures (eg hypothalamus, brainstem nuclei, hippocampal subfields). Columnar and laminar resolution of 7T fMRI will be used to understand the neuronal code, testing the predicted functional dissociations between cortical layers for hierarchical information processing. The cross linking of neurochemistry (MRS) with functional and structural data will reveal mechanisms of individual differences, in health and disorders, and potential stratification of therapeutic strategies. The new facility is part of the UK7T network, to promote knowledge transfer, data sharing, training, and coordinated of magnet supply. WBIC and CBSU have Master Research Agreements with Siemens and costs follow a Siemens 7T review, but tendering is open to all manufacturers. We require a minimum of 70mT/m gradients, 8 channel parallel transmission, 32 channel receiver, multinuclear spectroscopy and high order shimming. WBIC is controlled through a Clinical Radiology Information system to collect and monitor data, research protocols and scheduled transfer to PACS for long term secure storage, and secure access control. The proposed high performance informatics hub (data management plan) proposes to increase UoC data analysis capacity from 256 to 1024x16 Gb cores, fast user access to data and efficient parallel processing (using GRIDengine). A new informatics hub enhances integration with NHS systems and high volume data sharing with multisites (eg UKDP).
Planned Impact
Through the scientific program and investigators in the Case for Support, the new 7T facility in Cambridge will achieve Academic and Clinical Impacts on the major disorders of the brain: dementia, stroke, mental health and cognitive decline with ageing. In addition, we anticipate breakthroughs in understanding the normal human brain, its neuronal codes and network organisation.
Early Academic impacts include (i) the establishment of state of the art ultra-high imaging facility that will be widely used, ensuring that the Cambridge Biomedical Campus remains internationally competitive as a leading neuroscience centre; (ii) through our membership of the UK 7T network and the UK Dementias Platform, this facility will ensure the UK as a whole is seen as a global academic leader in MR imaging, especially relevant as MRI was discovered here; (iii) we will enhance the UK's competitive research advantage in biomedical imaging and maximize the impact of the MRC's investment across several areas of neuroscience, healthy ageing and dementia. The novel interdisciplinary programmes will advance knowledge globally, together with development and application of innovative methodologies to increase the UK knowledge economy. The evident long running impact of the MRCs intramural Cognition and Brain Sciences Unit, a key partner in this facility, will be amplified through access to cutting edge technologies with 7T MRI.
Early clinical scientific impact: we recognise that full clinical and health economic impact can take several years to fulfil, but we anticipate early clinical impacts in several areas. For example, greater sensitivity to plasticity underpins interventional studies for healthier cognitive ageing, in population derived cohorts. Early translation of basic discoveries to clinical disorders - with new therapeutic targets - is made possible, for example in the ability to test the vascular hypothesis in Huntington's disease, iron dysregulation in addiction, or CNS disorders in obesity.
Longer term health and economic impact come from better understanding, diagnosis and management of dementia, and thereby improved health, wellbeing and the UK economy. The 7T system will be a focus for training the next generation of researchers, both those involved in the study of the clinical disorders being examined, and methodologists to advance technological developments. The Facility coalesces a critical mass for exceptional teaching and learning, working closely with key academic groups locally (in the Schools of Medicine and Biological Sciences and the MRC Cognition and Brain Sciences Unit) and internationally.
Our longer term impact (~5 years) is not only to be measured through the high impact publications, major new grant awards, or even the training of a new cohort of students, researchers and future academic leaders. Our close integration with NHS services at local, regional and national level will ensure that advances are rapidly translated and disseminated for maximum early patient benefit. The imaging facility will catalyse inward commercial investment, including our partners in global pharmaceutical companies, with excellent prospects that innovations will lead to successful commercialisation.
Through our strong links with national bodies and guideline groups (e.g. NICE, MHRA, EFNS) we can ensure that academic advances at 7T imaging diffuse quickly to inform wider evidence based policy making and commissioning, directly and by guiding the translation to widely available systems and novel interventions. With increasing public interest and awareness of imaging and brain disorders such as dementia, the outward facing side of the Facility will increase public engagement with research in general, and with research in imaging and dementia in particular. This will be facilitated through our PPI programme and our links with local and national patient groups and other third sector organisations, most especially patient charities.
Early Academic impacts include (i) the establishment of state of the art ultra-high imaging facility that will be widely used, ensuring that the Cambridge Biomedical Campus remains internationally competitive as a leading neuroscience centre; (ii) through our membership of the UK 7T network and the UK Dementias Platform, this facility will ensure the UK as a whole is seen as a global academic leader in MR imaging, especially relevant as MRI was discovered here; (iii) we will enhance the UK's competitive research advantage in biomedical imaging and maximize the impact of the MRC's investment across several areas of neuroscience, healthy ageing and dementia. The novel interdisciplinary programmes will advance knowledge globally, together with development and application of innovative methodologies to increase the UK knowledge economy. The evident long running impact of the MRCs intramural Cognition and Brain Sciences Unit, a key partner in this facility, will be amplified through access to cutting edge technologies with 7T MRI.
Early clinical scientific impact: we recognise that full clinical and health economic impact can take several years to fulfil, but we anticipate early clinical impacts in several areas. For example, greater sensitivity to plasticity underpins interventional studies for healthier cognitive ageing, in population derived cohorts. Early translation of basic discoveries to clinical disorders - with new therapeutic targets - is made possible, for example in the ability to test the vascular hypothesis in Huntington's disease, iron dysregulation in addiction, or CNS disorders in obesity.
Longer term health and economic impact come from better understanding, diagnosis and management of dementia, and thereby improved health, wellbeing and the UK economy. The 7T system will be a focus for training the next generation of researchers, both those involved in the study of the clinical disorders being examined, and methodologists to advance technological developments. The Facility coalesces a critical mass for exceptional teaching and learning, working closely with key academic groups locally (in the Schools of Medicine and Biological Sciences and the MRC Cognition and Brain Sciences Unit) and internationally.
Our longer term impact (~5 years) is not only to be measured through the high impact publications, major new grant awards, or even the training of a new cohort of students, researchers and future academic leaders. Our close integration with NHS services at local, regional and national level will ensure that advances are rapidly translated and disseminated for maximum early patient benefit. The imaging facility will catalyse inward commercial investment, including our partners in global pharmaceutical companies, with excellent prospects that innovations will lead to successful commercialisation.
Through our strong links with national bodies and guideline groups (e.g. NICE, MHRA, EFNS) we can ensure that academic advances at 7T imaging diffuse quickly to inform wider evidence based policy making and commissioning, directly and by guiding the translation to widely available systems and novel interventions. With increasing public interest and awareness of imaging and brain disorders such as dementia, the outward facing side of the Facility will increase public engagement with research in general, and with research in imaging and dementia in particular. This will be facilitated through our PPI programme and our links with local and national patient groups and other third sector organisations, most especially patient charities.
Organisations
- University of Cambridge (Lead Research Organisation)
- University of Pisa (Collaboration)
- Medical University of Vienna (Collaboration)
- University of California, San Francisco (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Cancer Research UK Cambridge Institute (Collaboration)
- Cardiff University (Collaboration)
- University of Hong Kong (Collaboration)
- University Medical Center Utrecht (UMC) (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- University of Amsterdam (Collaboration)
- Life Molecular Imaging (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Siemens Healthcare (Collaboration)
- University College London (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- The Otto-von-Guericke University Magdeburg (Collaboration)
- National Institute for Health Research (Collaboration)
- German Centre for Neurodegenerative Diseases (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- PARAGRAF LIMITED (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- Apellis Pharmaceutical (Collaboration)
- EU Joint Programme - Neurodegenerative Disease Research (JPND) (Collaboration)
- ROYAL PAPWORTH HOSPITAL NHS FOUNDATION TRUST (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- Medical Research Council (Project Partner)
Publications
Cope TE
(2021)
Advances in neuroimaging to support translational medicine in dementia.
in Journal of neurology, neurosurgery, and psychiatry
Cope TE
(2023)
Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex.
in Cell reports
Davenport F
(2023)
Neurodegenerative disease of the brain: a survey of interdisciplinary approaches.
in Journal of the Royal Society, Interface
Ding B
(2021)
Water-suppression cycling 3-T cardiac 1 H-MRS detects altered creatine and choline in patients with aortic or mitral stenosis.
in NMR in biomedicine
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Title | 7T facility |
Description | New facility established for ultrahighfield MRI for dementia research and cognitive neuroscience |
Type Of Material | Model of mechanisms or symptoms - human |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | New MRC funded 7T research network established. |
Title | A Protocol for Ultra-High Field Laminar fMRI in the human brain |
Description | 1. Ultra-high field (UHF) fMRI across cortical depth. We have advanced high resolution EPI sequences for UHF imaging on the Cambridge 7T scanner and developed a rigorous pipeline for the analysis of sub-millimetre resolution fMRI including correction of vasculature-related artefacts. We have developed this pipeline as an open access tool, validated it across three different projects (publications in Current Biology, eLife, J Neuroscience) and published a protocol paper (STAR Protocols, in press). |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | 1. Ultra-high field (UHF) fMRI across cortical depth. We have advanced high resolution EPI sequences for UHF imaging on the Cambridge 7T scanner and developed a rigorous pipeline for the analysis of sub-millimetre resolution fMRI including correction of vasculature-related artefacts. We have developed this pipeline as an open access tool, validated it across three different projects (publications in Current Biology, eLife, J Neuroscience) and published a protocol paper (STAR Protocols, in press). |
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Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | We have advanced high resolution MR Spectroscopy imaging on the Cambridge 7T scanner for increased GABA detectability. We have optimised single voxel MRS sequences to achieve 15 mm isotropic resolution. |
Title | LC atlas |
Description | An atlas of locus ceruleus, currently as submisison in BioRxiv and and awaiting reviewers approval in Neuroimagine. This work is led by Dr Rong Ye. |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2020 |
Provided To Others? | Yes |
Impact | Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. The LC can be identified in vivo using non-invasive magnetic resonance imaging techniques which have potential as biomarkers for detecting and monitoring disease progression. We created a probabilistic atlas of the LC from 53 healthy older volunteers (52-84 years) using a sensitive magnetisation transfer sequence and ultrahigh field 7T MRI to investigate the LC structure in vivo at high-resolution. We would like to make the atlas available on NITRC for researchers, for replication or to facilitate accurate LC localisation and unbiased contrast extraction in future cognitive and clinical studies. |
Title | Sequence development and optimisation for 7T research |
Description | New sequences for brain and mental health research at 7T |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | Many studies are underway, but these have yet to be published, or to have reached health policy. Our progress has contributed to the national MR debate on higher field imaging in the UK, including nascent proposals for 14T imaging as a national research unit |
URL | https://www.wbic.cam.ac.uk/facilities/7t-terra |
Title | Siemens collaboration |
Description | We have negotiated research agreements with Siemens for 4 areas of collaborative development in MRI physics at 7T with the 7T physics group. These include developments in parallel transmit methods in the brain and body; developments in MR spectroscopy; and developments in whole-body metabolic imaging at 7T. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2018 |
Provided To Others? | No |
Impact | Impacts are expected during the course of the partnership |
Title | UK7T network harmonised protocols, pulse sequences and analysis pipelines |
Description | We have published together with the UK7T network a set of harmonised protocols, and make the associate pulse sequences and analysis pipelines available subject to the normal formalities for Siemens and Philips 7T MRI platforms. This is a companion set of tools linked to a paper https://www.sciencedirect.com/science/article/pii/S1053811919309267 |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | The UK7T network study has been an inspiration to a bid just submitted by the EUFIND consortium to the JPND scheme. (Sadly the UK chose not to participate in this funding round, otherwise we would have played a key part in the proposed study. We remain also close named collaborators.) |
URL | https://ora.ox.ac.uk/objects/uuid:55ca977f-62df-4cbf-b300-2dc893e36647 |
Title | DPUK 7T data sharing |
Description | Agreement on data sharing for 7T images using DPUK XNAT platform |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | pending |
Title | Data supporting "Avoiding monetary loss: a human habenula functional MRI ultra-high field study" |
Description | This file set includes all the data used for the corresponding publication: MRI, fMRI, behavioural, the group MNI template, the physiological data (cardiac and respiration), as well as all the ROIs created for the habenulae per participant and on the group level. The experimental task was programmed in presentation and the here included files contain the .sce and .pcl files used to create the task converted into word documents. Matlab analyses files for all analyses incorporated in the corresponding publication are also included. The file set is subdivided into the respective folders. The data of 18 participants was collected at Cambridge University, Wolfson Brain Imaging Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ. Assessment took place in the second half of 2019. The data was collected as part of a research grant for 7T imaging by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014) awarded to Valerie Voon. The anonymised dataset is being released to allow reuse by others aligned with the open science Cortex TOP guidelines. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
URL | https://www.repository.cam.ac.uk/handle/1810/319242 |
Title | MRC Dementia Platform UK |
Description | The DPUK is creating the world's largest population study for use in dementias research, bringing together two million participants aged 50 and over, from 22 existing study groups within the UK. Included are people from the general population, people known to be at-risk of developing dementia, and people diagnosed with early-stage dementia. |
Type Of Material | Database/Collection of data |
Year Produced | 2015 |
Provided To Others? | Yes |
Impact | By adding to information that we already know about the participants (such as their diet, exercise habits and previous infections) we hope to identify cognitive, genetic, physiological and imaging measures (biomarkers) to understand who is at risk of developing dementia and why the progression of dementia varies from person to person. The DPUK is taking a new approach that considers what is happening to the health of the person - looking not just at the brain but at the brain in the context of the whole body - to identify those changes that may best be associated with the early stages of dementia. Emerging evidence has linked the development of dementia with inflammatory, cardiovascular and metabolic events and disorders, and the DPUK will be able to test these interactions, potentially identifying new treatment options to both manage symptoms, in the near term, and for preventive approaches in the longer term. The platform will further allow the testing and validation of novel hypotheses by studying and comparing data from different DPUK cohorts. This will provide valuable feedback to inform future mechanistic research for example using stem cells or animal models. |
URL | http://www.mrc.ac.uk/research/facilities/dementias-platform-uk/ |
Title | Research data supporting "Recurrent processing drives perceptual plasticity" |
Description | Learning and experience are critical for translating ambiguous sensory information from our environments to perceptual decisions. Yet, evidence on how training molds the adult human brain remains controversial, as fMRI at standard resolution does not allow us to discern the finer-scale mechanisms that underlie sensory plasticity. Here, we combine ultra-high field (7T) functional imaging at sub-millimetre resolution with orientation discrimination training to interrogate experience-dependent plasticity across cortical depths that are known to support dissociable brain computations. Our results provide evidence for recurrent plasticity, by contrast to sensory encoding vs. feedback mechanisms. We demonstrate that learning alters orientation-specific representations in superficial rather than middle V1 layers, suggesting changes in read-out rather than input signals. Further, learning increases feedforward rather than feedback layer-to-layer connectivity in occipito-parietal regions, suggesting that sensory plasticity gates perceptual decisions. Our findings reveal finer-scale plasticity mechanisms that re-weight sensory signals to inform improved decisions, bridging the gap between micro- and macro- circuits of experience-dependent plasticity. $$ \ $$ See the file 'Description of uploaded data' for a detailed description of the dataset. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://www.repository.cam.ac.uk/handle/1810/309973 |
Description | 11.7 UHUF national imaging facility |
Organisation | University of Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | A new UKRI infrastructure award, led by Nottingham University, to establish a new 11.7 T MRI centre. Our role included the case for dementia and Parkinson's disease applications of the new technology; |
Collaborator Contribution | A multicentre UK consortium, led by Nottingham, for technical, physics, manufacturing and medical impact of the world-leading facility |
Impact | Award made. Planning ongoing to realise the physical infrastructure. |
Start Year | 2021 |
Description | Advanced neuro-spectroscopy |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | My group have implemented protocols and are developing advanced pulse sequences for MR spectroscopy and imaging in the human brain by 7T MRI. We have applied these Prof Rowe to study patients with dementias and COVID19, with Prof Kourzi to study cognitive processes in adaptive learning, and with Prof Henson to study semantic processing and the methods of laminar-resolved fMRI. |
Collaborator Contribution | Prof Rowe is an internationally recognised expert in dementias. He brings access to patients and to a large lab team to maximise the impact of our 7T MRI methods developments. Prof Kourtzi is an internationally recognised expert in adaptive learning and cognitive neuroscience. She brings access to a research group who specialise in studying learning processes. We have shown changes in GABA associated with a visual learning paradigm. Prof Henson is an internationally recognised expert in cognitive neuroscience and fMRI analysis. He brings access to his own research group and the teams at the MRC Centre for Brain Cognition in Cambridge. |
Impact | Papers/preprints: xx. Jia K, Zamboni E, Rua C, Reis Goncalves N, Kemper V, Ka Tsun Ng A, Rodgers CT, Williams GB, Goebel R, Kourtzi Z. A Protocol for Ultra-High Field Laminar fMRI in the human brain. Submitted to STAR Protocols. Preprint DOI: 10.17863/CAM.60568 xx. Huang P, Correia MM, Rua C, Rodgers CT, Henson RN, Carlin JD. Correcting for Superficial Bias in 7T Gradient Echo fMRI. Bioarxiv DOI 10.1101/2020.11.20.392258. Submitted to NeuroImage. 55. Rong Y, Rua C, O'Callaghan C, Jones PS, Hezemans F, Kaalund SS, Tsvetanov KA, Rodgers CT, Williams GB, Passamonti L, Rowe JB. An in vivo Probabilistic Atlas of the Human Locus Coeruleus at Ultra-high Field. Neuroimage. In Press. 54. Rua C, Clarke, WT, Driver ID, Mougin O, Morgan AT, Clare S, Francis S, Muire K, Porter D, Wise R, Carpenter TA, Williams GB, Rowe JB, Bowtell R, Rodgers CT. Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study. NeuroImage. In Press. DOI: 10.1016/j.neuroimage.2020.117358 52. Jia K, Zamboni E, Kemper V, Rua C, Reis Goncalves N, Ka Tsun Ng A, Rodgers CT, Williams GB, Goebel R, Kourtzi Z. Recurrent processing drives perceptual plasticity. Current Biology. In Press. DOI: 10.1016/j.cub.2020.08.016 51. Murley AG, Rouse MA, Jones PS, Ye R, Hezemans FH, O'Callaghan C, Frangou P, Kourtzi Z, Rua C, Carpenter TA, Rodgers CT, Rowe JB. GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition. NeuroImage 2020. DOI: 10.1093/brain/awaa305 Abstracts: 69. Rua C, O'Callaghan C, Passamonti L, Jones PS, Tsvetanov K, Rowe J, Ye R, Carpenter TA, Rodgers CT, Williams GB. Multi-modal 7T imaging of the Locus Coeruleus in healthy older adults. Proc. ISMRM 2019 (digital poster). 80. Rua C, Claire O'Callaghan, Ron Ye, Luca Passamonti, P Simon Jones, Williams GB, Rowe JB, Rodgers CT. In-vivo characterization of the biochemical properties of the locus coeruleus and substantia nigra in healthy controls and Parkinson's disease. (digital poster) 84. Rua C, Sanne Kaalund, Rowe JB, Rodgers CT, Williams GB. Layer-dependent Transient Saturation Transfer MRI at 7T. (digital poster) 93. Rua C, Llera A, Mougin O, Costagli M, Yakupov R, Bowtell R, Rowe JB, Rodgers CT. Linked Independent Component Analysis for Denoising multi-centre 7T MRI data. 97. Graf C, Clarke WT, Rua C, Newcombe VFJ, Lupson VC, Manktelow A, Chatfield DA, Sawcer SJ, Outtrim JG, Ersche K, Bullmore ET, Menon DK, Finnegan SL, McDonald R, Clare S, Ezra M, Rodgers CT, Pattinson K, Rowe JB. Two-site 7T 1H-MRS study in brainstem of "long COVID" patients. 99. Rua C, Rodgers CT, Newcombe VFJ, Manktelow A, Chatfield DA, Sawcer SJ, Outtrim JG, Lupson VC, Stamatakis EA, Williams GB,Clarke WT, Ersche KD, Pattinson K, Bullmore ET, Menon DK, Rowe JB. Characterization of brain susceptibility changes in post-hospitalisation COVID-19 patients at 7 Tesla. |
Start Year | 2017 |
Description | Cambridge 7T consortium |
Organisation | Medical Research Council (MRC) |
Department | MRC Cognition and Brain Sciences Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Forming the new University-MRC partnership and Cambridge 7T consortium. Full access to new facility for both partners. |
Collaborator Contribution | Staff allocation for physics support and adjunctive technologies for participant interaction. |
Impact | Multidisciplinary - dementia, neurology, psychiatry, development and ageing, cognitive neuroscience and physics. New head of 7T department has been recruited. |
Start Year | 2015 |
Description | Cambridge Centre for Parkinson-Plus (CCPP) |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Clinical Research Programme 1 - Biomarker investigation Clinical Trial 1: Atomoxetine in PSP patients |
Collaborator Contribution | several |
Impact | publications pending |
Start Year | 2018 |
Description | Cambridge Engineering superconductivity group |
Organisation | University of Cambridge |
Department | Cambridge Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are collaborating on the design of novel PERMANENT superconducting magnets with trapped flux for MRI. I cosupervise a PhD student Mr Mark Beck with Dr Mark Ainslie from the Engineering Dept. My contribution is to understand the necessary specification of magnet, to scope opportunities for impact in the imaging field beyond normal whole-body human MRI, and in due course I will oversee the construction of a demonstration MRI imaging system using custom open-source electronics for the console. I serve on the scientific advisory panel for an EPSRC project "Large Bulk (RE)BCO superconducting magnets for desktop NMR/MRI". https://gow.epsrc.ukri.org/NGBOViewGrant.aspx?GrantRef=EP/T014679/1 |
Collaborator Contribution | Dr Ainslie and Mr Beck are designing the new magnet to be used in this novel imaging system. |
Impact | Mr Beck's Y1 research report. COVID19 is making experimental science very challenging at this time. |
Start Year | 2019 |
Description | Claire O Callaghan - Restoring noradrenergic function to improve apathy in Parkinson s disease |
Organisation | University of Cambridge |
Department | Department of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Input on study design |
Collaborator Contribution | Study design, will do data collection and analyses, publications pending |
Impact | publications still pending |
Start Year | 2017 |
Description | Collaboration with Dr Ece Kocagoncu for NTAD (Dr A Jafarian) |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaboration on data analysis of test-retest data from NTAD. |
Collaborator Contribution | Availability of NTAD data. |
Impact | Title: Test-reTest reliability of dynamic casual modelling of resting states MEG data of Alzheimer patients. |
Start Year | 2022 |
Description | Collaboration with Dr. Gil Rabinovici at the Memory and Aging Center, Department of Neurology, University California San Francisco |
Organisation | University of California, San Francisco |
Country | United States |
Sector | Academic/University |
PI Contribution | Collaboration on project "Tau-PET and domain-specific cognitive decline in Alzheimer's disease", cross fertilization of research expertise. |
Collaborator Contribution | Hosted Post-Doc Dr M. malpetti for 4 month fellowship at UCSF. |
Impact | Reasearch paper: Malpetti M, La Joie R, Rabinovici GD. Tau beats amyloid in predicting brain atrophy in Alzheimer's disease: implications for prognosis and clinical trials. 2022, Journal of Nuclear Medicine - doi: 10.2967/jnumed.121.263694 |
Start Year | 2022 |
Description | Collaboration with Dr. Matthias Brendel at the Ludwig Maximilian University of Munich (Germany) and Prof. Pedro Rosa-Neto at the McGill University (Canada) |
Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
Country | Germany |
Sector | Academic/University |
PI Contribution | TSPO PET in tauopathies project, sharing of expertise |
Collaborator Contribution | TSPO PET in tauopathies project, sharing of expertise |
Impact | Research advancement |
Start Year | 2022 |
Description | Collaboration with Life Molecular Imaging & ACI Immune on FTD |
Organisation | Life Molecular Imaging |
Country | Germany |
Sector | Private |
PI Contribution | Expertise in PET Imaging of neurodegenerative disease. |
Collaborator Contribution | PET imaging of genetic FTD - 200,000 cases |
Impact | In progress |
Start Year | 2022 |
Description | Collaboration with Ludwig Maximillian University |
Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
Department | University Clinic of Munich |
Country | Germany |
Sector | Academic/University |
PI Contribution | Overlap with group research interests and activiity. Collaboration focuses on ageing and dementia. |
Collaborator Contribution | Academic expertise. |
Impact | In progress. |
Start Year | 2022 |
Description | Collaboration with Royal Papworth Hospital |
Organisation | Royal Papworth Hospital NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | My group have shown proof of principle for MRI and MRS study of hearts perfused with the mORGAN reperfuser from Royal Papworth Hospital. We are using this with transplant surgeon Prof Large to assess the effect of ex vivo perfusion on hearts and their suitability for transplant. We began in porcine hearts and will soon start with human hearts (funded, delayed by COVID19). We have shown that we can see epi and endocardial perfusion which is of key interest in preparing hearts from non-beating donors for transplant. We also see an array of metabolic changes. |
Collaborator Contribution | Prof Large's team are leading the world in cardiac transplant from non-beating donors. We are working with them to refine their technology for perfusion. |
Impact | We have exciting pilot data but our scans were suspended due to COVID19 so we have not acquired the numbers we wish to for publication yet. |
Start Year | 2019 |
Description | Collaboration with University of Edinburgh |
Organisation | University of Edinburgh |
Department | Edinburgh Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Intellectual expertise and collaborative links. A collaboration between University of Cambridge and University of Edinburgh linking Dementia Research Investigators with BRC and DPUK translational research programs. |
Collaborator Contribution | Intellectual expertise and collaborative links. A collaboration between University of Cambridge and University of Edinburgh linking Dementia Research Investigators with BRC and DPUK translational research programs. |
Impact | Providing direction and collaboration between dementia research investigators with BRC and DPUK translational research programs. |
Start Year | 2021 |
Description | Confidentiality & Material Transfer Agreements with Apellies Pharmaceuticals, Inc. |
Organisation | Apellis Pharmaceutical |
Country | United States |
Sector | Private |
PI Contribution | Focussed on the areas of synaptic health and fnction in dementia and neurodegeneration. |
Collaborator Contribution | As per agreement. |
Impact | Partnership ongoing, impacts expected in due course. |
Start Year | 2022 |
Description | Covid19 Neuroscience Group @7T |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New program of research into acute and chronic effects of COVID19 on the brain, including respiratory, cognitive and mental health effects Data collection of inpatients, and those recovering, from severe COVID19, and innovations in brain stem neurochemical imaging |
Collaborator Contribution | Expertise in spectroscopy and respiratory control from the brain Expertise in remote cognitive testing and normative data |
Impact | Pending publications Conference papers accepted, ISMRN, BNA |
Start Year | 2020 |
Description | Covid19 Neuroscience Group @7T |
Organisation | University of Oxford |
Department | Oxford Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New program of research into acute and chronic effects of COVID19 on the brain, including respiratory, cognitive and mental health effects Data collection of inpatients, and those recovering, from severe COVID19, and innovations in brain stem neurochemical imaging |
Collaborator Contribution | Expertise in spectroscopy and respiratory control from the brain Expertise in remote cognitive testing and normative data |
Impact | Pending publications Conference papers accepted, ISMRN, BNA |
Start Year | 2020 |
Description | Deuterium metabolic imaging |
Organisation | Cancer Research UK Cambridge Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am implementing an approach for deuterium magnetic resonance imaging on the 7T MRI system in Cambridge to trace glucose uptake and metabolism. In this collaboration with Prof Brindle (CRUK-CI) and Dr Mair (Neurosurgery) and others, I am leading the technical development for 7T. |
Collaborator Contribution | Prof Brindle has extensive experience of DMI in preclinical settings, including in glioblastoma tumour models. Dr Mair brings access to glioblastoma patients undergoing surgery. We plan to perform human studies imminently. |
Impact | No outputs yet. |
Start Year | 2018 |
Description | Deuterium metabolic imaging |
Organisation | National Institute for Health Research |
Department | NIHR Cambridge Biomedical Research Centre |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am implementing an approach for deuterium magnetic resonance imaging on the 7T MRI system in Cambridge to trace glucose uptake and metabolism. In this collaboration with Prof Brindle (CRUK-CI) and Dr Mair (Neurosurgery) and others, I am leading the technical development for 7T. |
Collaborator Contribution | Prof Brindle has extensive experience of DMI in preclinical settings, including in glioblastoma tumour models. Dr Mair brings access to glioblastoma patients undergoing surgery. We plan to perform human studies imminently. |
Impact | No outputs yet. |
Start Year | 2018 |
Description | GENFI3 |
Organisation | University College London |
Department | Institute of Neurology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | A new collaboration to exploit the enhanced sensitivity of 7T vs 3T imaging to understand preclinical genetic dementia, in support of early phase trials Expertise in 7T imaging of FTD cohorts |
Collaborator Contribution | Leadership of the international GENFI consortium into the third phase Expertise on biomarker development |
Impact | Grant submission underway Pilot work in preparation |
Start Year | 2020 |
Description | HKU AI partnership |
Organisation | University of Hong Kong |
Country | Hong Kong |
Sector | Academic/University |
PI Contribution | A new Cambridge UK to HKU partnership for to develop Artificial Intelligence for Social Good, in biomedicine |
Collaborator Contribution | Establishing the partnership, developing research strategy, and funding applications, from private and statutory bodies |
Impact | Pending |
Start Year | 2022 |
Description | JPND EUFIND - European Ultrahigh Field Imaging Biomarkers for Dementia |
Organisation | EU Joint Programme - Neurodegenerative Disease Research (JPND) |
Country | European Union (EU) |
Sector | Public |
PI Contribution | An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. We have contributed expertise, data, and engaged in a pilot study for feasibility and methods development |
Collaborator Contribution | An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. Our partners from 20 EU sites have contributed expertise, data, and engaged in a pilot study for feasibility and methods development |
Impact | A project initiation report is submitted to JPND |
Start Year | 2016 |
Description | LC collaboration |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have engaged with two UCL groups who have a shared interest in noradrenergic systems, and imaging f the locus ceruleus in particular, with data sharing and plans for joint papers. |
Collaborator Contribution | New sequences and clinical applications of the MR technology |
Impact | A joint position paper Data sharing |
Start Year | 2018 |
Description | Medical University of Vienna |
Organisation | Medical University of Vienna |
Country | Austria |
Sector | Academic/University |
PI Contribution | I hosted Prof Albrecht Ingo Schmid for 1 year at my lab in Oxford. We taught him to run cardiac 31P-MRS at 7T. He has now established a group at the Medical University of Vienna working in this area. |
Collaborator Contribution | Prof Schmid implemented a "STEAM" pulse sequence during his time with us, which we have used to image cardiac intracellular pH for the first time. We have assessed the effects of diabetes and heart failure. |
Impact | Apps A, Valkovic L, Peterzan M, Lau JYC, Hundertmark M, Clarke WT, Tunnicliffe EM, Ellis J, Tyler DJ, Neubauer S, Rider O, Rodgers CT*, Schmid AI* (joint senior authors). Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers; a 31P MRS study at 7T. Magn Reson Med. In Press. Valkovic L, Clarke WT, Schmid AI, Raman B, Ellis J, Watkins H, Robson MD, Neubauer S, Rodgers CT. Measuring inorganic phosphate and intracellular pH in the healthy and diseased human heart by in vivo 7T 31P-MRS. J Cardiov Magn Reson. DOI: 10.1186/s12968-019-0529-4 PMC 82329 (in progress) ISMRM 2018 abstracts: 53. Schmid AI, Valkovic L, Tunnicliffe EM, Rodgers CT. Unambiguous detection of cardiac Pi using long TM 31P STEAM. Proc. ISMRM 2018 (e-poster). 54. Valkovic L, Batzakis A, Ellis J, Purvis LAB, Schmid AI, Robson MD, Klomp D, Rodgers CT. Whole-body 7T 31P birdcage transmit coil driven by a 35kW RF amplifier with an integrated 30-element 31P receive array and an 8-element 1H transmit/receive array. Proc. ISMRM 2018 (oral). 55. Valkovic L, Schmid AI, Purvis LAB, Ellis J, Neubauer S, Rodgers CT. Quantification of human cardiac inorganic phosphate content in vivo by 31P-MRSI at 7T. Proc. ISMRM 2018 (e-poster). ISMRM 2019 abstracts: 59. Valkovic L, Ellis J, Purvis LAB, Schmid AI, Neubauer S, Rodgers CT. First assessment of cardiac energy metabolism in the lateral and inferior segments of the left ventricle in vivo at 7T. Proc. ISMRM 2019 (power-pitch oral). 61. Choi C-H, Valkovic L, Clarke WT, Schmid AI, Shah NJ, Rodgers CT. NOE enhancement for 31P-MRS of skeletal and cardiac muscle at 7T. Proc. ISMRM 2019 (digital poster). 62. Schmid AI, Apps AP, Valkovic L, Tunnicliffe EM, Clarke WT, Peterzen MA, Neubauer S, Rider OJ, Rodgers CT. Human cardiac pH and Pi concentration during dobutamine stress measured by 7T 31P-MRS. Proc. ISMRM 2019 (digital poster). ISMRM 2020 abstract: 76. Apps A, Lau J, Ellis J, Peterzan M, Hundertmark M, Tyler DJ, Schmid AI, Neubauer S, Oliver Rider, Valkovic L, Rodgers CT. Myocardial Pi/PCr and pH during stress at 7T with STEAM 31P MRS in dilated cardiomyopathy; heart failure beyond the ejection fraction. (power-pitch oral) ISMRM 2021 accepted abstract: 94. Valkovic L, Apps A, Ellis J, Tyler DJ, Neubauer S, Schmid AI, Rider OJ, Rodgers CT. Increased Cardiac Pi in the Diabetic Heart Observed Using STEAM 31P MRS at 7T. |
Start Year | 2015 |
Description | Metabolic imaging in liver EU H2020 "NICI" project |
Organisation | University Medical Center Utrecht (UMC) |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Dr Rodgers is the work package leader for data processing. We are leading the integration of this multinuclear metabolic imaging technology on the Siemens platform. |
Collaborator Contribution | Development of novel whole-body coils for the consortium. Organoid study to target metabolites of interest. |
Impact | Several abstracts have been submitted to the ISMRM 2019 and 2020 annual meetings. (www.ismrm.org) |
Start Year | 2018 |
Description | Metabolic imaging in liver EU H2020 "NICI" project |
Organisation | University of Amsterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Dr Rodgers is the work package leader for data processing. We are leading the integration of this multinuclear metabolic imaging technology on the Siemens platform. |
Collaborator Contribution | Development of novel whole-body coils for the consortium. Organoid study to target metabolites of interest. |
Impact | Several abstracts have been submitted to the ISMRM 2019 and 2020 annual meetings. (www.ismrm.org) |
Start Year | 2018 |
Description | Metabolic imaging in liver EU H2020 "NICI" project |
Organisation | University of Pisa |
Country | Italy |
Sector | Academic/University |
PI Contribution | Dr Rodgers is the work package leader for data processing. We are leading the integration of this multinuclear metabolic imaging technology on the Siemens platform. |
Collaborator Contribution | Development of novel whole-body coils for the consortium. Organoid study to target metabolites of interest. |
Impact | Several abstracts have been submitted to the ISMRM 2019 and 2020 annual meetings. (www.ismrm.org) |
Start Year | 2018 |
Description | NIHR BRC |
Organisation | National Institute for Health Research |
Department | NIHR Cambridge Biomedical Research Centre |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Biomarker development, including cognitive and imaging based deep phenotyping; |
Collaborator Contribution | Cellular, physiological, radio-chemistry, genetic and pharmaceutical innovations within a pipeline for novel drug discovery; |
Impact | Adams, N. E., Hughes, L. E., Phillips, H. N., Shaw, A. D., Murley, A. G., Nesbit, D., Cope, T. E., Bevan-Jones, W. R., Passamonti, L., Rowe, J. B. (2020). GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco magnetoencephalography, Journal of Neuroscience, https://doi.org/10.1523/JNEUROSCI.1689-19.2019. Lewis-Smith, D. J., Wolpe, N., Ghosh, B. C. P., Rowe, J. B. (2020). Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia, Journal of Neurology, https://doi.org/10.1007/s00415-019-09672-8. Jabbari, E., Chelban, V., Holland, N., Jones, P. S., Lamb, R., Rawlinson, C., Guo, T., Costantini, A. A., Tan, M. M. X., Heslegrave, A. J., Roncaroli, F., Klein, j. C., Ansorge, O., Allinson, K. S. J., Jaunmuktane, Z., Holton, J. L., Revesz, T., Warner, T. T., Lees, A. J., Zetterberg, H., Russell, L. L., Bocchetta, M., Rohrer, J. D., Williams, N. M., Grosset, D. G., Burn, D. J., Pavese, N., Gerhard, A., Kobylecki, C., Leigh, P. G., Church, A., Hu, M. T. M., Woodside, J., Houlden, H., Rowe, J. B., Morris, H. R. (2020). Diagnosis across the spectrum of progressive supranuclear palsy and corticobasal syndrome, JAMA Neurology, doi:10.1001/jamaneurol.2019.4347. van der Ende, E. L,, Meeter, L. H., Poos, J. M., Panman, J. L., Jiskoot, L. C., Dopper, E. G. P., Papma, J. M., de Jong, F. J., Verberk, I., Teunissen, C. E., Rizopoulos, D., Heller, C., Convery, R. S., Moore, K. M., Bocchetta, M., Neason, M., Cash, D. M., Borroni, B., Galimberti, D., Sanchez-Valle, R., Laforce, Jr R., Moreno, F., Synofzik, M., Graff, C., Masellis, M., Tartaglia, M. C., Rowe, J. B., Vandenberghe, R., Finger, E., Tagliavini, F., de Mendonça, A., Santana, I., Butler, C., Ducharme, S., Gerhard, A., Danek, A., Levin, J., Otto, M., Frisoni, G. B., Cappa, S., Pijnenburg, Y. A. L., on behalf of the GENetic Frontotemporal Dementia Initiative (GENFI), Rohrer, J. D., van Swieten, J. C. (2019). Longitudinal serum neurofilament light chain in genetic frontotemporal dementia: a multicentre cohort study. Lancet Neurology, 18: 1103-1111, https://doi.org/10.1016/S1474-4422(19)30354-0. Shafto, M. A., Henson, R. N., Matthews, F. E., Taylor, J. R., Emery, T., Erzinclioglu, S., Hanley, C., Rowe, J. B., Cusack, R., Calder, A. J., Marslen-Wilson, W. D., Duncan, J., Dalgleish, T., Brayne, C., Cam-CAN, Tyler, L. K. (2019). Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project, Journal of Aging and Health, doi: 10.1177/0898264319878095 [ahead of print], PMID: 31592706 Lansdall, C. J., Coyle-Gilchrist, I. T. S., Vázquez Rodríguez, P., Wilcox, A., Wehmann, E., Robbins, T. W., Rowe, J. B. (2019). Prognostic importance of apathy in syndromes associated with Frontotemporal lobar Degeneration, Neurology, 92(14):e1547-e1557. doi: 10.1212/WNL.0000000000007249, PMID: 30842292, PMC: 6448451. Borchert, B. J., Rittman, T., Rae, C. L., Passamonti, L., Jones, P. S., Vatansever, D., Vazquez-Rodriguez, P., Ye, Z., Nombela, C., Hughes, L. E., Robbins, T. W., Rowe, J. B. (2019). Atomoxetine and citalopram alter brain network organization in Parkinson's disease, Brain Communications, 1:1 fcz013, https://doi.org/10.1093/braincomms/fcz013. PMID: [pending], PMC: [pending]. Nicastro, N., Surendranathan, A., Mak, E., Rowe, J. B.*, O'Brien, J. T.* (2019). 11C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia, Annals of Clinical and Translational Neurology, doi: 10.1002/acn3.50877, PMID: 31507085, PMC: [pending]. Low, A., Mak, E., Malpetti, M., Chouliaras, L., Nicastro, N., Su, L., Holland, N., Rittman, T., Vázquez Rodríguez, P., Passamonti, L., Bevan-Jones, W. R., Jones, P. S., Rowe, J. B.*, O'Brien, J. T.* (2019). Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features, Alzheimer's & Dementia: Diagnosis, Assessment, & Disease Monitoring, 11: 690-699, DOI: https://doi.org/10.1016/j.dadm.2019.08.001, PMID: 31667328, PMC: 6811895. Tavares, T. P., Mitchell, D. G. V., Coleman, K., Shoesmith, C., Bartha, R., Cash, D. M., Moore, K. M., van Swieten, J. C., Borroni, B., Galimberti, D., Tartaglia, M. C., Rowe, J. B., Graff, C., Tagliavini, F., Frisoni, G., Cappa, S., Laforce, R. Jr, de Mendonça, A., Sorbi, S., Wallstrom, G., Masellis, M., Rohrer, J. D., Finger, E. C., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Ventricular volume expansion in presymptomatic genetic frontotemporal dementia, Neurology, doi: 10.1212/WNL.0000000000008386, PMID: 31578297, PMC: [pending]. Passamonti, L., Tsvetanov, K. A., Jones, P. S., Bevan-Jones, W. R., Arnold, R., Borchert, R. J., Mak, E., Su, L., O'Brien, J. T.*, Rowe, J. B.* (2019). Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2574-18.2019. PMID: 31320450, PMC: 6733539. Jabbari, E., Woodside, J., Guo, T., Magdalinou, N. K., Chelban, V., Athauda, D., Lees, A. J., Foltynie, T., Houlden, H., Church, A., Hu, M. T., Rowe, J. B., Zetterberg, H., Morris, H. R. (2019). Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes, Journal of Neurology, Neurosurgery and Psychiatry, 90(7):768-773. doi: 10.1136/jnnp-2018-320151. PMID: 30867224, PMC: 6585258. Hughes, L. E., Henson, R. N., Pereda, E., Bruña, R., López-Sanz, D., Quinn, A. J., Woolrich, M. W., Nobre, A. C., Rowe, J. B., Maestú, F., BioFIND Working Group (2019). Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography, Alzheimers & Dementia (Amsterdam, Netherlands), 11:450-462. doi: 10.1016/j.dadm.2019.04.009. PMID: 31431918, PMC: 6579903. Shaw, A. D., Hughes, L. E., Moran, R., Coyle-Gilchrist, I., Rittman, T., Rowe, J. B. (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies. Cerebral Cortex. 2019. doi: 10.1093/cercor/bhz024. PMID: 31216360. van Eimeren, T., Antonini, A., Berg, D., Bohnen, N., Ceravolo, R., Drzezga, A., Höglinger, G. U., Higuchi, M., Lehericy, S., Lewis, S., Monchi, O., Nestor, P., Ondrus, M., Pavese, N., Peralta, M.C., Piccini, P., Pineda-Pardo, J. Á., Rektorová, I., Rodríguez-Oroz, M., Rominger, A., Seppi, K., Stoessl, A. J., Tessitore, A., Thobois, S., Kaasinen, V., Wenning, G., Siebner, H. R., Strafella, A. P., Rowe, J. B. (2019). Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimers & Dementia (Amsterdam, Netherlands). 11:301-309. doi: 10.1016/j.dadm.2019.01.011. PMID: 30984816, PMC: 6446052. Rittman, T., Borchert, R., Jones, P. S., van Swieten, J., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Graff, C., Tagliavini, F., Frisoni, G. B., Laforce, R. Jr, Finger, E., Mendonça, A., Sorbi, S., Rohrer, J. D., Rowe, J. B., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia, Neurobioly of Aging, 77:169-177. doi: 10.1016/j.neurobiolaging.2018.12.009, PMID: 30831384; PMC: 6491498. Bevan-Jones, W. R., Cope, T. E., Jones, P. S., Passamonti, L., Hong, Y. T., Fryer, T., Arnold, R., Coles, J. P., Aigbirhio, F. I., O'Brien, J. T., Rowe, J. B. (2019). In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier. Annals of Clinical Translational Neurology, 6(2):373-378. doi: 10.1002/acn3.683. PMID: 30847369; PMC: 6389753. |
Start Year | 2017 |
Description | Ongoing collaboration between Dr A Jafarain (Rowe Group) and Prof. Karl Firston (UCL) |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributions to the development of Multimodal Dynamic Causal Modelling for projects in translational neuroscience and dementia. |
Collaborator Contribution | Professional expertise and collaboration sought. |
Impact | Jafarian, A., Hughes, L.E., Adams, N.E., Lanskey, J., Naessens, M., Rouse, M.A., Murley, A.G., Friston, K.J. and Rowe, J.B., 2022. Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy. bioRxiv, pp.2022-06. |
Start Year | 2020 |
Description | PREVENT 7T |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Application of 7T technology to understand the effects of inherited risk of dementia |
Collaborator Contribution | Coordination of national PREVENT study of people at risk of dementia |
Impact | Pending |
Start Year | 2019 |
Description | Paragraf |
Organisation | Paragraf Limited |
Country | United Kingdom |
Sector | Private |
PI Contribution | Paragraph developed very sensitive magnetic field sensors based on graphene. Our work together focuses on application of the magnetic field sensors in Ultra High Field MRI in order to deliver precise characteristic of both static and time dependent (generated by the gradient coils) magnetic fields used in MRI scanners. The characterization includes measurements of timing, magnitude and orientation of the magnetic field in various points in space during the imaging. The study aims to validate the sensors' compatibility with the scanner and utilize the obtained field characteristic in order to improve quality of MR imaging. A Non Disclosure Agreement has been put in place and experiments with the sensors has been planned but were interrupted by COVID19. |
Collaborator Contribution | Paragraph developed very sensitive magnetic field sensors based on graphene. They are providing these on loan for us to assess in an MRI environment. They could provide a new tool to correct image inhomogeneity caused by gradient imperfections or form the basis of a motion sensor. |
Impact | None yet. |
Start Year | 2020 |
Description | Parallel transmit workshop collaboration |
Organisation | German Centre for Neurodegenerative Diseases |
Country | Germany |
Sector | Public |
PI Contribution | We hosted Ed Pracht from DZNE to learn hands-on parallel transmit programming. We have subsequently joined forces with his group at DZNE and Siemens to run our first parallel transmit 7T MRI workshop with 61 delegates from across Europe. These will now continue quarterly. |
Collaborator Contribution | We hosted Dr Pracht in Cambridge. We hosted the first parallel transmit workshop on MS Teams. |
Impact | Outputs will follow. This is community building at this stage. |
Start Year | 2020 |
Description | Siemens collaboration |
Organisation | Siemens Healthcare |
Country | Germany |
Sector | Private |
PI Contribution | In establishing the new 7T MRI Research Facility, we have actively enganged with Siemens to revise and optimise the facility on an accelarated timescale. We will be the first non-Germany site to test their new Terra System, and to apply Terra to dementia and neuroscience disciplines. |
Collaborator Contribution | ?810,000 budgetary revision and 'no-cost' like-for-like upgrade of core technologies of circa ?750,000. Fellowship, on-site engineer for 12months and Scientist for 18 months circa ?260,000. So, total Siemens contribution ~?1,820,000. Subsequent substantial in kind contribution negotiated |
Impact | Delivery on time and on budget of new facility in 2016. Since 2017: Standard sequences are in in place with good QC/QA, and the scanner is in use for several research studies in clinical populations, ageing and development. The scanner is booked >80% now for clinical and cognitive neuroscience studies. We have negotiated research agreements with Siemens for 4 areas of collaborative development in MRI physics at 7T with the 7T physics group. These include developments in parallel transmit methods in the brain and body; developments in MR spectroscopy; and developments in whole-body metabolic imaging at 7T. |
Start Year | 2015 |
Description | Supervisor with Caius Higher Aspiration Scheme - Rebecca Williams (Rowe Group) |
Organisation | University of Cambridge |
Department | Gonville and Caius College |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Supervisor to 6 students (Year 12) |
Collaborator Contribution | Aspiration Scheme |
Impact | Student development. |
Start Year | 2022 |
Description | UK 7T MRI network |
Organisation | Cardiff University |
Department | Brain Research Imaging Centre (CUBRIC) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards. |
Collaborator Contribution | establishing a new 7T imaging network, with new CRI funding |
Impact | A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians. |
Start Year | 2016 |
Description | UK 7T MRI network |
Organisation | University of Glasgow |
Department | Institute of Neuroscience and Psychology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards. |
Collaborator Contribution | establishing a new 7T imaging network, with new CRI funding |
Impact | A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians. |
Start Year | 2016 |
Description | UK 7T MRI network |
Organisation | University of Nottingham |
Department | School of Biomedical Sciences Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards. |
Collaborator Contribution | establishing a new 7T imaging network, with new CRI funding |
Impact | A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians. |
Start Year | 2016 |
Description | UK 7T MRI network |
Organisation | University of Oxford |
Department | Oxford Centre for Functional MRI of the Brain (FMRIB) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant. Updated input for 2019 - 2020 - Dr Rodgers (Cambridge Head of 7T MRI Physics) was elected coordinator of the UK7T network from 1 Nov 2019 onwards. |
Collaborator Contribution | establishing a new 7T imaging network, with new CRI funding |
Impact | A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians. |
Start Year | 2016 |
Description | UK7T Network |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
Start Year | 2021 |
Description | UK7T Network |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
Start Year | 2021 |
Description | UK7T Network |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
Start Year | 2021 |
Description | UK7T Network |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
Start Year | 2021 |
Description | UK7T Network |
Organisation | University of Nottingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
Start Year | 2021 |
Description | UK7T Network |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The UK7T network promotes the acceleration of ultrahigh field MRI for biomedical research, including harmonisation, standardisation, sharing and joint research programs across the seven UK7T networks and liaison with the European EUFIND consortium for 7T MRI. |
Collaborator Contribution | Data sharing, sequence sharing, training opportunities, QC and translational pilot studies |
Impact | Multi-disciplinary - neuroscience, physics, chemistry, data sciences, medicine, Prior to DPUK collaboration there was a MRC Partnership award. |
Start Year | 2021 |
Description | Ultrahigh resolution imaging of neurodegeneration and vascular risk in aging and preclinical and prodromal Alzheimer's Disease |
Organisation | The Otto-von-Guericke University Magdeburg |
Country | Germany |
Sector | Academic/University |
PI Contribution | New consortium to faciliate and validate 7T in dementia research, across 15 EU sites. Meets and draft preparation |
Collaborator Contribution | Led by Prof Duzel, Magdeburg, a consortium building on EUFIND. |
Impact | None yet. Funding sought |
Start Year | 2019 |
Title | Atomoxetine in PSP |
Description | new drug strategy for impulsivity in PSP to be tested for first time. |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2017 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | reduced impulsivity in selected patients |
Title | Biomarker evaluation of 7T MRI in dementia |
Description | evaluation of novel 7T MRI for early detection of pathology in AD, and other dementias, building on the JPND consortium "EUFIND" |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2020 |
Development Status | Under active development/distribution |
Impact | stronger links to basic cognitive neurosciences of memory systems, and to multi-centre clinical transnational centres across EU |
Title | Tiagabine in FTLD |
Description | New drug strategy for impulsivity in FTLD tested for first time. |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2021 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Reduced impulsivity in selected patients. |
Title | Novel MRI pulse sequences for imaging and spectroscopy in vivo |
Description | We have published abstracts describing novel imaging and spectroscopy pulse sequences at the ISMRM 2019 and 2020 annual meetings. Particular focus areas include: neuromelanin imaging (by MT sensitised MRI), FatNav motion correction with reconstruction in an open source tool, multinuclear spectroscopy tools for the 7T Terra platform. |
Type Of Technology | New/Improved Technique/Technology |
Year Produced | 2019 |
Impact | These methods are now being used in studies in Cambridge. Dr Pracht from DZNE Bonn visited us in Jan 2020 to learn more about our parallel transmit implementations on the 7T Terra. |
Description | (Dr Rua) ISMRM 2020 - In-vivo characterization of the biochemical properties of the locus coeruleus and substantia nigra in healthy controls and Parkinson's disease |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2020 |
URL | https://archive.ismrm.org/2020/1532.html |
Description | (Dr Rua) ISMRM 2020 - Initial experience on 7T Terra for human parallel transmit (pTx) liver imaging |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2020 |
URL | https://archive.ismrm.org/2020/4288.html |
Description | (Dr Rua) ISMRM 2020 - Investigation of pTx pulses for magnetisation inversion on 7T Terra |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2020 |
URL | https://archive.ismrm.org/2020/4276.html |
Description | (Dr Rua) ISMRM 2020 - Layer-dependent Transient Saturation Transfer MRI at 7T |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2020 |
URL | https://archive.ismrm.org/2020/3112.html |
Description | (Dr Rua) ISMRM 2020 - Parallel transmit (pTx) with online pulse design for task-based fMRI at 7T |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.ismrm.org/20/program_files/DP11-02.htm |
Description | (Prof Kourtzi) Talk at 25th Annual Meeting of the Organization for Human Brain Mapping, Rome, Italy (2019) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Ultra-high field fMRI reveals cortical depth specificity for adaptation in the human visual cortex. 2019. Elisa Zamboni, Valentin G. Kemper, Nuno R. Goncalves, Ke Jia, Rainer Goebel and Zoe Kourtzi, 25th Annual Meeting of the Organization for Human Brain Mapping, Rome, Italy. |
Year(s) Of Engagement Activity | 2019 |
Description | (Prof Kourtzi) Vision Sciences Society, St Petersburg, Florida, USA 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Ultra-high field imaging of perceptual learning in the human visual cortex. 2019. Ke Jia, Elisa Zamboni, Nuno Reis Goncalves, Catarina Rua, Valentin Kemper, Guy Williams, Chris Rodgers and Zoe Kourtzi, Vision Sciences Society, St Petersburg, Florida, USA. |
Year(s) Of Engagement Activity | 2019 |
Description | 23rd National Dementia Conference: Talk on "Frontotemporal Dementia" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | An update on FTD landscape and research output from Rowe group. |
Year(s) Of Engagement Activity | 2021 |
Description | ARUK Clinical Conference. talk titled "What's new in Frontotemporal Dementia?" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This conference focussed on the themes of research, innovation, and implementing change in clinical practice. |
Year(s) Of Engagement Activity | 2021 |
Description | All About Brians - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Virtual contribution at Storyhouse Theatre Chester, UK. |
Year(s) Of Engagement Activity | 2022 |
Description | Article about our research in AuntMinnie trade magazine |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Our study in COVID patients was covered by the AuntMinnie.com trade magazine. |
Year(s) Of Engagement Activity | 2021 |
Description | Big Biology Day - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Live at Hills Road Sixth Form, collaboration with ARUK |
Year(s) Of Engagement Activity | 2022 |
Description | Brain Bus Initiative @ Cambridge by MRC-CBU Researchers |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | The purpose of the BrainBus project is to provide a pivotal outreach experience to underprivileged children, exposing them to subjects, careers and role models which they would not otherwise access. The project brings a range of diverse neuroscientists and purpose-designed interactive neuroscience activities into the primary classrooms, at no charge to the schools. The aim is to start a cascade of experiences to support underrepresented individuals, including those from ethnic minorities and less privileged socio-economic backgrounds, to engage in science and, eventually, higher education and science careers. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.mrc-cbu.cam.ac.uk/brain-bus/ |
Description | Brain Conference, talk given on "Apathy and Impulsivity" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation during cognition and dementia theme of Brain conference 2021. |
Year(s) Of Engagement Activity | 2021 |
Description | Brain Models & Pipecleaner Neurons (Rebecca Williams - Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Collaboration with CHaOS - live at school in St. Neots, UK |
Year(s) Of Engagement Activity | 2022 |
Description | British Neuropathological Society meeting, Cirencester, UK 3-5 July 2019 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Attended by Dr Luca Passamonti and Dr Sanne Kaalund to strenghten their network in neuropathology research. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.bns.org.uk/wp-content/uploads/2018/12/Programme_BNSSummerSchool2019.pdf |
Description | CBU Methods Day training workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Training in MRI methods for the Cambridge community |
Year(s) Of Engagement Activity | 2022 |
Description | CCPP patient liaison |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | A patient liaison group, to advise and feedback on experience of research participation, and future studies' documentation. |
Year(s) Of Engagement Activity | 2018,2019 |
Description | CHaOS Summer Roadshow (Rebecca Williams - Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Live at Poacher Scout's Jamboree (over 6000 in attendance) |
Year(s) Of Engagement Activity | 2022 |
Description | Cambridge Imaging Festival, Cambridge 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Luca Passamonti presented a talk titled: Integrative brain imaging to understand and treat dementia. |
Year(s) Of Engagement Activity | 2019 |
URL | https://radiology.medschl.cam.ac.uk/wp-content/uploads/2019/05/CIF-Programme-with-link.pdf |
Description | Cambridge Neuroscience Postdoc Symposium, University of Cambridge |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Showcasing research outputs on 7T imaging of Locus Coeruleus in neurodegenerative disease by Dr Rong Ye. |
Year(s) Of Engagement Activity | 2019 |
Description | Chris Rodgers - 7T seminar & ISMRM Nordic Chapter meeting, Norway |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk at combined 7T seminar & ISMRM Nordic Chapter meeting, Norway |
Year(s) Of Engagement Activity | 2018 |
Description | Chris Rodgers - Biennial Minnesota MRI workshop, Minneapolis, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk at the 12th Biennial Minnesota MRI workshop, Minneapolis, USA, one of the worlds leading events for advanced imaging researchers. An opportunity to showcase the progress made under this grant. |
Year(s) Of Engagement Activity | 2019 |
Description | Chris Rodgers - British Chapter ISMRM Annual Meeting, Oxford, UK. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk at the British Chapter of ISMRM Annual Meeting, Oxford, UK. |
Year(s) Of Engagement Activity | 2018 |
Description | Chris Rodgers - ISMRM Ultra-high field workshop 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The 2019 ISMRM Ultra-high Field Workshop, Croatia, to deliver an invited talk. The ISMRM is the principal international organisation for MRI research, and this meeting is dedicated to UHF imaging, including the showcasing of developments made during my Sir Henry Dale Fellowship and its extension. |
Year(s) Of Engagement Activity | 2019 |
Description | Coordinator FTDUK Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | FTDUK - coordinator and talk London |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ftduk.org/previous-programmes/#1684055574796-923f2281-2b7e |
Description | Coping with Exam Stress - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Schools |
Results and Impact | In collaboration with Study Together |
Year(s) Of Engagement Activity | 2022 |
Description | Dementia Chatathon - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Collaboration with Dementia Researcher, watched via Youtube, Twiter & Twitch |
Year(s) Of Engagement Activity | 2022 |
Description | Dementia Researcher Podcasts and Fundraising events - Dr M Malpetti |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | https://www.dementiaresearcher.nihr.ac.uk/tag/dr-maura-malpetti/ |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.dementiaresearcher.nihr.ac.uk/tag/dr-maura-malpetti/ |
Description | Dr D Street Poster Presentation @ Alzheimer's Association International Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prodromal markers of neurodegenerative disease - insights from UK Biobank. Alzheimer's Association International Conference Annual Meeting 2021 poster presentation. |
Year(s) Of Engagement Activity | 2021 |
URL | https://alz.confex.com/alz/2021/meetingapp.cgi/Paper/49865 |
Description | Dr D Street Poster Presentation @ American Association of Neurology on Prodromal Parkinson's disease - insights from UK Biobank |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prodromal Parkinson's disease - insights from UK Biobank. American Academy of Neurology Annual Meeting 2021 poster presentation. |
Year(s) Of Engagement Activity | 2021 |
URL | https://index.mirasmart.com/AAN2021/PDFfiles/AAN2021-002229.html |
Description | Dr D Street: Thesis in 3 Minutes Talk at UK Biobank Scientific Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Thesis in three minutes. Three-minute talk as part of the UK Biobank Scientific Conference 2021. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=_zTsJIbgWIk |
Description | Dr M Malpetti - Host of Clinical Neurosciences Seminar & Conversation with Prof. JB Rowe |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Discussion on "From mechanisms to treatment, in disorders of frontotemporal lobar degeneration." |
Year(s) Of Engagement Activity | 2021 |
Description | Dr Maura Malpetti - ROWE GROUP MEMBER Invited speaker at Alzheimer's Association International Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Invited as a speaker on Brain inflammation in frontotemporal dementia. ISTAART conversation with patients and carers. |
Year(s) Of Engagement Activity | 2021 |
Description | Dr Maura Malpetti - ROWE GROUP MEMBER Organizing committee member "My memory clinic and me" Cambridge Festival 2021 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | My memory clinic and me" at Cambridge Festival 2021 - a session held for those interested in neurodegenerative diseases. |
Year(s) Of Engagement Activity | 2021 |
URL | https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d |
Description | Effective Note Taking Strategies: Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Schools |
Results and Impact | Collaboration with Study Together |
Year(s) Of Engagement Activity | 2022 |
Description | Expert review panel for magnetic resonance spectroscopy at the ISMRM Annual Meeting 2020 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I participated as one of four panel members giving an expert summary and review of presentations at the ISMRM's 2020 Annual Meeting. Our review covered developments in magnetic resonance spectroscopy. We maximised our zoom online session attendee limit for a one hour discussion. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.ismrm.org/20m/ |
Description | Filmed Charity Broadcast for PSP Association |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | PSPA broadcast. |
Year(s) Of Engagement Activity | 2022 |
Description | How to Tackle an Academic Paper - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | How to Tackle an Academic Paper |
Year(s) Of Engagement Activity | 2022 |
Description | How to tackle Academic Teading and Writing - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Summer CAMP collaboration. |
Year(s) Of Engagement Activity | 2022 |
Description | Imaging the Locus Coeruleus with Ultra-high 7T MRI - DRCMR Copenhagen, Denmark |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The purpose of the workshop was to communicate research outputs generated by Prof James Rowe's group to Danish future collaborators, particularly by Dr Rong Ye and Dr Catarina Rua (both specialising in 7T imaging) and the use of 7T in neurodegenerative disease. The main outcome of this newly forged collaboration was to provide analysis pipeline advice to Danish group. |
Year(s) Of Engagement Activity | 2019 |
Description | In Conversation at Christmas - Broadcast on Dementia |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | In conversation at Christmas is a stimulating discussion, covering some of the progress made in research in 2022, and looking ahead to 2023. Hear from our Chief Scientific Officer, Prof James Rowe and Head of Research, Dr Rosa Sancho and ambassador for Alzheimer's Research UK, Scott Mitchell. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.youtube.com/watch?v=Vwp8QNIJSZ4 |
Description | International Congress of Parkinson's Disease and Movement Disorders - Nice 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Advances in PSP and its overlap with FTD, main meeting and satellite symposia on PSP and Brain Imaging |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.mdscongress.org/Congress-Branded/19FP-_blue_puzzle_online.pdf |
Description | Invited lecture at ultra-high field study group symposium at the ISMRM Annual Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I was invited to survey the areas of opportunity for ultra-high field imaging in the human heart. This lecture should have been delivered in Sydney in Apr 2020 but was postponed due to COVID19. It is now scheduled for the forthcoming meeting in May 2021. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.ismrm.org/21m/ |
Description | Invited session chair at Alzheimer's Association International Conference 2021, USA - Dr M Malpetti |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Chaired session on "Neuroimaging: Molecular Imaging of Novel Biomarkers for Neurodegeneration and ADRD" session at AAIC 2021 (07/2021 - Denver USA) |
Year(s) Of Engagement Activity | 2021 |
Description | Invited speaker at 7TMRI group University of Cambridge- Dr Amirhossein Jafarian |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Title: Prior in DCM and MRS informed dynamic causal modelling. |
Year(s) Of Engagement Activity | 2021 |
Description | Let's Talk Science - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Skyped in to Birmingham, USA |
Year(s) Of Engagement Activity | 2022 |
Description | Let's Talk Science! Skype a Scientist, Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Schools |
Results and Impact | Engagement via Skype a Scientist to Missouri, USA. |
Year(s) Of Engagement Activity | 2022 |
Description | Locus Coeruleus Imaging Meeting Magdeburg 2019 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This workshop was attended by Dr Luca Passamonti, Dr Sanne Kaalund, Dr Rong Ye and Dr Catarina Rua. The team were showcasing research in LC and the use of 7T. At this years LC meeting, we aim to focus on the following questions: 1. How can we improve structural / functional / PET LC imaging? 2. What is the role and fate of the LC in neurodegenerative and clinical conditions? What renders the LC particularly vulnerable? 3. What have we learned (also from animal research) on the LCs role in cognition and behavior in the last years? 4. What are the most promising interventions targeting the LC / NA system? We will post a detailed program on the website and send it via email to all registered users at a later date. Please see information on our previous meeting held last February and the resultant consensus paper summarizing how LC imaging can be used for clinical research in neurodegenerative diseases. New for this years meeting are 1-2 methods workshops for those interested: A two day hackathon (Saturday 14th and Sunday 15th) where MR physicists will do some hands-on tests to explore new imaging approaches (this will be mostly relevant for MR physicists doing LC imaging) If there is enough interest, an extra session on LC methods in animal research (electrophysiology, high-field imaging, optogenetics, ...) which will take place on Saturday 14th. Please let us know if you would like to join either of these! |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.iknd.ovgu.de/LC+Meeting+2019.html |
Description | MEGUK Oral Presentation by Dr Amirhossein Jafarian (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Gave an oral presentation titled Multimodal Dynamic causal modelling |
Year(s) Of Engagement Activity | 2021 |
Description | MRC CBU Science Night - Cambridge Science Festival 2019 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Demonstrations of research studies, including VR game |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.mrc-cbu.cam.ac.uk/blog/2019/01/mrc-cbu-science-night-cambridge-science-festival-2019/ |
Description | MRI motion correction - invited talk at KBFI CoE EQUiTANT seminar, Tallinn, Estonia - Dec. 2020 by Dr Klodowski |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Klodowski from my research group gave this invited talk. |
Year(s) Of Engagement Activity | 2020 |
Description | My Memory Clinic and Me |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Presented at an event titled My Memory Clinic and Me as part of the Cambridge Festival in March 2021. The Cambridge Memory Clinic provides assessment and management for a wide range of memory and cognitive disorders, for example, due to neurodegeneration (Alzheimer's disease, Mild Cognitive Impairment, Frontotemporal dementia, Dementia with Lewy Bodies) and more. A discussion was help about memory clinics in the context of dementia. How they can help, and what to expect - including their role in leading research that matters to patient care. Short presentations followed by a live Q&A session with consultant neurologists. |
Year(s) Of Engagement Activity | 2021 |
URL | https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d |
Description | National Advertising Campaign with Alzheimer's Research UK |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | National advertising campaign |
Year(s) Of Engagement Activity | 2021,2022 |
Description | Neuro2024 (PSP/CBS symposium) - Dr Negin Holland (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral Presentation: Neuro2024 (PSP/CBS symposium) - October 2023; attendees over 400 Title: Title: Differential patterns of in vivo synaptic loss in relation to tau accumulation and grey matter atrophy, in amyloid negative vs. positive corticobasal syndrome. Poster Presentation Award received. |
Year(s) Of Engagement Activity | 2023 |
Description | OLS/UKRI cross sector specialist workshop/committee for new national dementia initiative strategy for 2022 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Meeting with No.10 officials on UK Dementia landscape. |
Year(s) Of Engagement Activity | 2021,2022 |
Description | Oral Presentation @ ADPD Barcelona 20222- Dr M Malpetti |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | "In vivo PET imaging of inflammation as a prognostic tool in frontotemporal dementia" - ADPD conference (Barcelona, 03/2022) |
Year(s) Of Engagement Activity | 2022 |
Description | Oral Presentation Dr D Street at Midlands Neurological Society Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation Non-motor markers predict survival in PSP |
Year(s) Of Engagement Activity | 2022 |
Description | Oral Presentation Dr M Malpetti (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | • "Inflammation markers in prodrome and prediction of dementia" - Interdisciplinary Dementia and Aging Centre (iDEAC) at University Hospital Southampton NHS Foundation Trust (Southampton, UK, 23/05/2023) |
Year(s) Of Engagement Activity | 2023 |
Description | Oral Presentation Dr M Malpetti (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | • "Brain inflammation in dementia: what can we learn from PET imaging and blood markers?" - CUBRIC Seminar Series at the Cardiff University Brain Imaging Center (Cardiff, 09/10/2023) |
Year(s) Of Engagement Activity | 2023 |
Description | Oral Presentation Dr M Malpetti (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | • "Novel PET Tracers for Dementia" - SINdem4Juniors: 11th Winter Seminar on Dementia and Neurodegenerative Disorders (Brixen, 16/02/2024) |
Year(s) Of Engagement Activity | 2024 |
Description | Oral Presentation Dr M Malpetti (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | • "Inflammation in dementia: a target for new treatments?" - NIAS Expert Workshop For Women in Science 2023 (Amsterdam, 13/07/2023) |
Year(s) Of Engagement Activity | 2023 |
Description | Oral Presentation: Caius Higher Aspiration Scheme - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Caius Higher Aspiration Scheme |
Year(s) Of Engagement Activity | 2023 |
Description | Organisation of Human Brain Mappinh annual meeting, Rome 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dissemination of research outputs stemming from analyses conducted by Dr Rong Ye at the Clinical Neurosciences department (supervisor Prof James Rowe). The presentation was part of the symposium on neurodegenerative and vascular disorders and how 7T can improve the clinical research in this area. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.pathlms.com/ohbm/courses/12238/sections/15845/video_presentations/138100 |
Description | PPE - Cambridge university Hospitals Trust members |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | An evening event for the members of the Trust (patients, and local public) to discuss advances in dementia research and care, including the insights from new technologies |
Year(s) Of Engagement Activity | 2019 |
Description | PPIE Dementia Group Event at Peckover House, Wisbech (Rowe Group) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Peckover House, Wisbech Lucy Bowns, Dr Maura Malpetti, Rebecca Williams Observations/thoughts/comments • Peckover House has been given funding to provide this dementia group. Currently it is the only National Trust property to offer this. It is hoped that it might expand to another five sites, pending ongoing funding. |
Year(s) Of Engagement Activity | 2023 |
Description | Pint of Science: Atoms to Galaxies |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Events held live in Cambridge UK |
Year(s) Of Engagement Activity | 2022 |
Description | Powerpitch on parallel transmit ultra-high field MRI at the EUFIND meeting at the DZNE, Bonn |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I presented our recent work on ultra-high field parallel transmit functional imaging and a proposal for the future EUFIND consortium funding bid to include parallel transmit aspects. |
Year(s) Of Engagement Activity | 2020 |
Description | Presentation and interview for Y12 student open day at Peterhouse (HE+ Visit) |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | I gave a presentation and then answered questions on research, undergraduate teaching and university life from a group of Y12 students visiting Cambridge as part of the HE+ Visit scheme. |
Year(s) Of Engagement Activity | 2019 |
Description | Prof J B Rowe: "Restoring brain function in dementia", Beacon workshop, University of Nottingham (12th April '19) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Restoring brain function in dementia @ Nottingham Beacon workshop Beacon workshop on sensorimotor brain oscillations #914915804 When: 12 April 2019 |
Year(s) Of Engagement Activity | 2019 |
Description | Prof J B Rowe: EUFIND Bonn 7T meeting talk: "Neurochemistry of frontotemporal lobar degeneration: frontotemporal dementia and progressive supranuclear palsy" (30th Jan '20) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 30th January Bonn EUFIN meeting for 7T - Neurochemistry of frontotemporal lobar degeneration: frontotemporal dementia and progressive supranuclear palsy |
Year(s) Of Engagement Activity | 2020 |
Description | Prof J B Rowe: Magdeburg/DZNE Locus Coeruleus "Noradrenergic deficit and restoration in Progressive Supranuclear Palsy" (12th Dec '19) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 12th Dec Magdeburg/DZNE LC meeting - "Noradrenergic deficit and restoration in Progressive Supranuclear Palsy |
Year(s) Of Engagement Activity | 2019 |
Description | Public lecture at Institution of Engineering and Technology Cambridge group |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Industry/Business |
Results and Impact | Gave invited evening lecture at the Institution of Engineering and Technology's Cambridge local group. |
Year(s) Of Engagement Activity | 2020 |
URL | https://communities.theiet.org/communities/events/item/229/77/23208 |
Description | Rittmann, T. (14th May 2018). The story of a noisy brain. Pint of Science, Annual Science Festival, Castle Bar, Cambridge, UK |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Increase awareness. Discuss science with general public |
Year(s) Of Engagement Activity | 2018 |
Description | Rowe - BBC Look East (2016) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | 7T for dementia research |
Year(s) Of Engagement Activity | 2016 |
Description | Rowe - Cambridge Science Festival (2017) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Lecture at Cambridge Science Festival |
Year(s) Of Engagement Activity | 2017 |
Description | Rowe - Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. University of Cambridge News for Medical Design Technology (2016) |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Rowe, J. B. (24th October 2016). Cambridge extends world leading role for medical imaging with powerful new brain and body scanners. University of Cambridge News for Medical Design Technology. http://www.cam.ac.uk/research/news/cambridge-extends-world-leading-role-for-medical-imaging-with-powerful-new-brain-and-body-scanners |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.cam.ac.uk/research/news/cambridge-extends-world-leading-role-for-medical-imaging-with-pow... |
Description | Rowe - FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge (2017). |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Rowe, J. B. (13th September 2017). FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge; give feedback to carers and also get feedback from them. |
Year(s) Of Engagement Activity | 2017 |
Description | Rowe - FTD-UK Annual Meeting (2017) - Debate |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A discussion of imaging's contribution to FTD diagnosis, prognosis and stratification |
Year(s) Of Engagement Activity | 2017 |
Description | Rowe - First dementia patient is scanned. BRC Communications, R D Newsletter, Cambridge Biomedical Research Centre (2017) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Rowe, J. B. (6th October 2017). First dementia patient is scanned. BRC Communications, R&D Newsletter, Cambridge Biomedical Research Centre. |
Year(s) Of Engagement Activity | 2017 |
Description | Rowe - For the Dementia Awareness Week: Professor James Rowe of @CamNeuro on Cambridge s role in dementia research. University of Cambridge, (2017). |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Rowe, J. B. (17th May 2017). For the Dementia Awareness Week: Professor James Rowe of @CamNeuro on #Cambridge's role in dementia research. University of Cambridge, Cambridge TV @cambridgetvnews (Twitter Video). https://twitter.com/cambridgetvnews/status/864790164861800448; awareness for dementia |
Year(s) Of Engagement Activity | 2017 |
URL | http://twitter.com/cambridgetvnews/status/864790164861800448 |
Description | Rowe - Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association) (2017) |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Rowe, J. B. (16th May 2017). Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association). |
Year(s) Of Engagement Activity | 2017 |
Description | Rowe Group Member Dr NEGIN HOLLAND gave talk: Synaptic imaging in dementia and neurodegenerative disease @ Cambridge Imaging Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | This is a meeting of users and experts within the Cambridge NHS and academic community. Results and data are shared as well as new perspectives and applications for novel imaging methods. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.mrc-cbu.cam.ac.uk/wp-content/uploads/2021/05/Programme-Cambridge-Imaging-Festival-2021.p... |
Description | Rowe Group: Dr D Street - Fresh Thinking at Fitz: The value of Memories |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Virtual fifteen-minute talk followed by panel discussion on current research in memory disorders. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.fitz.cam.ac.uk/news/fresh-thinking-fitz-value-memories |
Description | Rowe Group: M Naessens Talk @ AAIC Neuroscience Next Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Gave a lightening round talk titled "7T imaging in behavioural variant frontotemporal dementia and progressive supranuclear palsy." |
Year(s) Of Engagement Activity | 2021 |
Description | Rowe Group: M Naessens talk at Cambridge Festival 2021 - My Memory Clinic and Me |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Study participants or study members |
Results and Impact | Dementia focussed session during Cambridge Festival. |
Year(s) Of Engagement Activity | 2021 |
Description | Rowe/Team - Cambridge Science Festival (2017) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | A lecture on the challenge of dementia as part of the Cambridge Science Festival |
Year(s) Of Engagement Activity | 2017 |
Description | Session Chair: Cognition at Brain 2022 Conference |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Chaired session on congnition with research presentations on: 1. Transdiagnostic approaches to cognitive disorders and their underlying brain pathology 2. Dissociable brain microstructural diffusivity changes underlying visual short -term memory deficits in Alzheimer's disease. 3. Bayesian Brains and the origin of functional disorders. 4. 'Socioeconomic status impacts cognitive and socioemotional processes in healthy ageing: evidence from Latin American older adults. 5. Noradrenergic treatment of cognitive disorders: big news from the blue spot. |
Year(s) Of Engagement Activity | 2022 |
URL | https://thebrainconference.co.uk/brain-conference-schedule/ |
Description | Sir Peter Mansfield Imaging Centre, Nottingham |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited seminar at the Sir Peter Mansfield Imaging Centre, Nottingham |
Year(s) Of Engagement Activity | 2019 |
Description | Specialist PSP Sub-group @ Movement Disorder Society International Conference: UHF 7T Imaging |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Expert panel meeting on imaging and Progressive supranuclear palsy. |
Year(s) Of Engagement Activity | 2021 |
Description | Sutton Trust MEG Talks - Rebecca Williams (Rowe Group) |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Event held at the MRC Cognition Brain Unit |
Year(s) Of Engagement Activity | 2022 |
Description | Talk at - Alzheimer's Association International Conference 2021, Dr Maura Malpetti |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | "Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia" - Alzheimer's Association International Conference |
Year(s) Of Engagement Activity | 2021 |
Description | Talk by Dr M Malpetti at (ISTAART) Scientific Meeting: What have we learnt from PET in FTD in the last 10 years? |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | "What have we learnt from PET in FTD in the last 10 years" - ISTAART FTD and Neuroimaging PIAs webinar: An update on neuroimaging in frontotemporal dementia (virtual event) |
Year(s) Of Engagement Activity | 2021 |
Description | Talk by Dr M Malpetti at Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Scientific Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk title: Neuroinflammation in medial temporal regions predicts cognitive decline in dementia with Lewy bodies |
Year(s) Of Engagement Activity | 2021 |
Description | Talk by Dr M Malpetti at Clinical Neurosciences Away Day, Cambridge University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Talk title: Neuroinflammation in frontotemporal lobar degeneration: a target for treatment? |
Year(s) Of Engagement Activity | 2021 |
Description | Telegraph on Florence Pugh visit to University of Cambridge with Race Against Dementia - Rowe Group |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Florence Pugh: 'Ever since I posted about dementia, so many people have reached out to me' When she's not busy with her hectic Hollywood schedule, the star is using her voice - and huge following - to support Race Against Dementia |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.telegraph.co.uk/christmas/2024/01/24/florence-pugh-oppenheimer-race-against-dementia-cha... |
Description | The Dementia UK Ecosystem and Innovations in biomarkers @ Cambridge Memory Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | The aim of this Cambridge-wide memory group is to encourage interaction between the many local labs working on the psychology/neuroscience of short- and long-term memory, both human and non-human. The talk given to this audience gave an overview of the key UK institutions and partners involved in dementia research aimed at identifying new biomarkers for plausibale clinical translation. |
Year(s) Of Engagement Activity | 2021 |
URL | http://www.memlab.psychol.cam.ac.uk/CAMM/index.html |
Description | Tim Sandhu Talk @ CamBrain Cambridge Neuroscience Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Oral presentation to junior researchers or those interested in neuroscience. Title "Learning under uncertainty in autism and anxiety" |
Year(s) Of Engagement Activity | 2021 |
Description | Voice of Islam - Dementia |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Discussion on voice of islam broadcast on the theme of dementia to raise public awareness, especially within the Muslim community. |
Year(s) Of Engagement Activity | 2022 |
Description | Voice of Islam Radio - Dementia Theme |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Voice of Islam broadcast discussion on dementia. |
Year(s) Of Engagement Activity | 2021 |
Description | WBIC presentation at Physics at Work - Sep. 2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Dr Klodowski from my group presented in the Physics at Work outreach event. |
Year(s) Of Engagement Activity | 2020 |
Description | Year 12 student taster |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | A "taster lecture" to 6th form students visiting Cambridge on an outreach visit. For students in the Biology / Chemistry / Medicine stream, promoting accessibility and engagement with University applications in STEM. |
Year(s) Of Engagement Activity | 2019 |