MICA: Accelerating Development of Infection Diagnostics for Patient Management and Reduction of Antibiotic Misuse
Lead Research Organisation:
University of Leeds
Department Name: Electronic and Electrical Engineering
Abstract
The discovery of antibiotics early in the 20th century revolutionised healthcare provision and antibiotics and other antimicrobials have become an integral part of modern healthcare. However, in recent decades, the use of antibiotics has increased massively, not only in healthcare provision but also in veterinary and agricultural (live stock) applications. This has led to an enormous rise in antimicrobial resistance (AMR), which is forming an ever-growing problem in modern healthcare, proving a serious threat to society. The number of instances where infections are resistant against common antibiotics is increasing rapidly, and bacterial infections with strains that are resistant to almost all known antibiotics (e.g. meticillin-resistant staphylococcus aureusis, MRSA) have contributed to a significant number of death (almost 300 in 2012, source: Office for National Statistics) and caused significant problems for affected patients and healthcare providers.
The solution seems simple: drastically reduce the prescriptions of antimicrobials. However, where antimicrobials are required for medical treatment, withholding prescription is dangerous for the patient and unethical, and could furthermore negatively impact on the general public through increased spreading rates.
There are two major types of infections: viral and bacterial. Only bacterial infections can be treated with antibiotics, but certain symptoms are common to both types of infections. A typical example is throat pain, which could be caused by a bacterial infection (e.g. Streptococcus pneumonia) or viral (e.g. influenza), or in fact could be caused by non-infection causes such as heart failure. More critical examples include meningitis, which, when caused by a bacterial infection (meningococcal disease) needs immediate medical attention, while viral meningitis tends to take a milder course requiring rest and observation for encephalitis.
We argue that antimicrobial prescriptions can be reduced safely and ethically if better infection diagnosis is available. Many infections are viral in origin (and hence do not benefit from antibiotics), but often antibiotics are prescribed as a precaution as without suitable diagnostics the doctor cannot be sure what the origin of the infection is. Although some laboratory-based tests are currently available, these can take several days to give a clear answer, and hence precautionary antibiotic treatments are started before the test results are available.
In this research programme we will develop rapid diagnostic tests that can be performed by the doctor her/himself, i.e. a GP in a primary care clinic or a consultant in a hospital, which will give an answer in less than 15 minutes, quick enough to inform treatment before it is prescribed.
The first diagnostic test that this programme will develop will thus be to distinguish between viral and bacterial infections. Once a bacterial infection is diagnosed, or if symptoms are encountered which indicate bacterial infections, it is important to identify the bacterial strain that causes the infection, as different strains require different antibiotic treatments. The second diagnostic test that this project aims to develop is thus to test for pathogen that causes the infections and we have chosen the example of C. difficile infections, a common infection that causes severe diarrhoea. Finally, many bacteria are now resistant to common antibiotics and if the type of resistance is known, the antibiotic treatment can be tailored to be effective. The third diagnostic test that will be developed is thus to diagnose a common subtype of Carbapenem Resistant Enterobacteriaceae (CRE), which is common type of infection with antibiotic resistance. These quick and accurate tests will reduce the prescription of the wrong antibiotics, which will not only reduce to the total amount of antibiotics used (thus reducing AMR), but will also lead to a more effective patient management.
The solution seems simple: drastically reduce the prescriptions of antimicrobials. However, where antimicrobials are required for medical treatment, withholding prescription is dangerous for the patient and unethical, and could furthermore negatively impact on the general public through increased spreading rates.
There are two major types of infections: viral and bacterial. Only bacterial infections can be treated with antibiotics, but certain symptoms are common to both types of infections. A typical example is throat pain, which could be caused by a bacterial infection (e.g. Streptococcus pneumonia) or viral (e.g. influenza), or in fact could be caused by non-infection causes such as heart failure. More critical examples include meningitis, which, when caused by a bacterial infection (meningococcal disease) needs immediate medical attention, while viral meningitis tends to take a milder course requiring rest and observation for encephalitis.
We argue that antimicrobial prescriptions can be reduced safely and ethically if better infection diagnosis is available. Many infections are viral in origin (and hence do not benefit from antibiotics), but often antibiotics are prescribed as a precaution as without suitable diagnostics the doctor cannot be sure what the origin of the infection is. Although some laboratory-based tests are currently available, these can take several days to give a clear answer, and hence precautionary antibiotic treatments are started before the test results are available.
In this research programme we will develop rapid diagnostic tests that can be performed by the doctor her/himself, i.e. a GP in a primary care clinic or a consultant in a hospital, which will give an answer in less than 15 minutes, quick enough to inform treatment before it is prescribed.
The first diagnostic test that this programme will develop will thus be to distinguish between viral and bacterial infections. Once a bacterial infection is diagnosed, or if symptoms are encountered which indicate bacterial infections, it is important to identify the bacterial strain that causes the infection, as different strains require different antibiotic treatments. The second diagnostic test that this project aims to develop is thus to test for pathogen that causes the infections and we have chosen the example of C. difficile infections, a common infection that causes severe diarrhoea. Finally, many bacteria are now resistant to common antibiotics and if the type of resistance is known, the antibiotic treatment can be tailored to be effective. The third diagnostic test that will be developed is thus to diagnose a common subtype of Carbapenem Resistant Enterobacteriaceae (CRE), which is common type of infection with antibiotic resistance. These quick and accurate tests will reduce the prescription of the wrong antibiotics, which will not only reduce to the total amount of antibiotics used (thus reducing AMR), but will also lead to a more effective patient management.
Technical Summary
The lack of instant and accurate diagnostic tools for infectious diseases leads to inappropriate or unnecessary antibiotic prescribing. In primary care and hospital settings, this contributes directly and significantly to antimicrobial resistance (AMR). The aim of this programme is to address this challenge by developing innovative approaches for the next generation biosensors.
This programme aims to develop three biosensors that (a) distinguish between viral and bacterial infections and (b) specifically diagnose Clostridium difficile infection (CDI) and (c) detect common subtypes carbapenemases which cause the most problematic forms of Carbapenem Resistant Enterobacteriaceae (CRE) infections. Diagnostic biomarkers have been previously established to for these infection diagnosis applications and in this programme synthetic antibody mimetics (Adhirons) will be raised/selected against these biomarkers. Using the Adhirons as 'recognition elements', multiplexed, impedimetric and fluormetric biosensors will be constructed based on established and novel technologies, respectively.
Furthermore, this programme aims to develop novel biosensor platforms with improved accuracy and sensitivity. The majority of biosensors use passive capture molecules, such as antibodies or antibody mimetics, as 'recognition elements'. However, while antibody-biomarker binding is generally highly specific, changes in dielectric upon binding of biomarkers can be small, limiting the sensitivity and reproducibility of the sensor. Furthermore, non-specific binding of other molecules onto the sensor can lead to false-positive signals. Here, these bottlenecks will be targeted by designing new classes of antibody mimetics that generate an active electrochemical signal upon binding of the biomarkers.
This programme aims to develop three biosensors that (a) distinguish between viral and bacterial infections and (b) specifically diagnose Clostridium difficile infection (CDI) and (c) detect common subtypes carbapenemases which cause the most problematic forms of Carbapenem Resistant Enterobacteriaceae (CRE) infections. Diagnostic biomarkers have been previously established to for these infection diagnosis applications and in this programme synthetic antibody mimetics (Adhirons) will be raised/selected against these biomarkers. Using the Adhirons as 'recognition elements', multiplexed, impedimetric and fluormetric biosensors will be constructed based on established and novel technologies, respectively.
Furthermore, this programme aims to develop novel biosensor platforms with improved accuracy and sensitivity. The majority of biosensors use passive capture molecules, such as antibodies or antibody mimetics, as 'recognition elements'. However, while antibody-biomarker binding is generally highly specific, changes in dielectric upon binding of biomarkers can be small, limiting the sensitivity and reproducibility of the sensor. Furthermore, non-specific binding of other molecules onto the sensor can lead to false-positive signals. Here, these bottlenecks will be targeted by designing new classes of antibody mimetics that generate an active electrochemical signal upon binding of the biomarkers.
Planned Impact
This proposal describes the development, analytical and clinical validation of point-of-care biosensors for the rapid and reliable diagnosis of infection for the reduction of antibiotic misuse and improved patient management. This programme will impact on a range of stakeholders, including: patients; healthcare providers; clinicians/clinical scientists; manufacturers of in vitro diagnostics.
1 Patients: Our technology will provide tools for healthcare providers to determine accurately and rapidly the origin of an infection, thus benefitting patients directly. For example, if a GP or emergency physician could use a rapid point-of-care test to distinguish bacterial from viral respiratory tract infection, it would allow them to target antibiotic prescriptions to patients most likely to benefit. A similar argument applies to C. difficile infection (CDI), where rapid and accurate diagnosis of CDI is important to enable use of a broader set of antibiotics as well as quarantining patients quickly to avoid spread of the infection. Furthermore, our programme will reduce AMR, which will indirectly benefit all patients as well as the general population.
2 Clinicians and healthcare providers: This programme will lead to a reduction in AMR and therefore reducing the number of patients infected by anti-microbial resistant pathogens. This leads to significant cost savings for healthcare-service providers (reduced treatment costs, fewer quarantining of patients, etc) as well as reduced risk for their staff. Additional cost savings will result from the availability of low-cost tests which replace more expensive traditional tests.
3 Manufacturers of in vitro diagnostics (IVD): The outputs of this programme will provide manufacturers of IVD instrumentation with new technologies that have the potential to monitor biomarkers more accurately, sensitively, and reliably, and hence enable new modalities of operation (such as rapid point-of-care analysis). This will increase their capabilities and competitiveness. Our generic technology will not only find application in clinical diagnostics, but has the potential to produce an analytical technology that can be used in over-the-counter diagnostic tests (e.g. well-being testing), environmental monitoring (e.g. water pollution), veterinary practice (e.g. animal screening), and security (e.g. detection of biological/chemical agents).
4 Academics across a broad range of scientific disciplines: Research and results from this programme will find widespread use, interest, and generate impact, across the wider academic community beyond clinical science, notably in biosensors, clinical microbiology, microfluidics, AMR, and bionanotechnology (see 'Academic Beneficiaries for more details).
5 The PDRAs on the programme will benefit from the training and development opportunities offered through this challenging interdisciplinary programme. The project will bring together scientists from a wide range of backgrounds with industry and clinical end-users, therefore benefitting the PDRAs through networking opportunities, and significantly increasing employability in academia, industry, and regulatory bodies, inter alia (see 'Academic Beneficiaries for more details).
IP arising from this research will be exploited fully through, e.g., direct licensing, or through University spin-out companies, as appropriate. The investigators have extensive experience in both approaches, e.g. the spin-out companies Relitect Ltd (co-founder Wälti) and Elisha Ltd (co-founder Millner) (both manufacturers of biosensor technologies), or the Adhiron license to Avacta Plc for commercial exploitation of Leeds' antibody mimetics (co-inventors McPherson, Tomlinson).
1 Patients: Our technology will provide tools for healthcare providers to determine accurately and rapidly the origin of an infection, thus benefitting patients directly. For example, if a GP or emergency physician could use a rapid point-of-care test to distinguish bacterial from viral respiratory tract infection, it would allow them to target antibiotic prescriptions to patients most likely to benefit. A similar argument applies to C. difficile infection (CDI), where rapid and accurate diagnosis of CDI is important to enable use of a broader set of antibiotics as well as quarantining patients quickly to avoid spread of the infection. Furthermore, our programme will reduce AMR, which will indirectly benefit all patients as well as the general population.
2 Clinicians and healthcare providers: This programme will lead to a reduction in AMR and therefore reducing the number of patients infected by anti-microbial resistant pathogens. This leads to significant cost savings for healthcare-service providers (reduced treatment costs, fewer quarantining of patients, etc) as well as reduced risk for their staff. Additional cost savings will result from the availability of low-cost tests which replace more expensive traditional tests.
3 Manufacturers of in vitro diagnostics (IVD): The outputs of this programme will provide manufacturers of IVD instrumentation with new technologies that have the potential to monitor biomarkers more accurately, sensitively, and reliably, and hence enable new modalities of operation (such as rapid point-of-care analysis). This will increase their capabilities and competitiveness. Our generic technology will not only find application in clinical diagnostics, but has the potential to produce an analytical technology that can be used in over-the-counter diagnostic tests (e.g. well-being testing), environmental monitoring (e.g. water pollution), veterinary practice (e.g. animal screening), and security (e.g. detection of biological/chemical agents).
4 Academics across a broad range of scientific disciplines: Research and results from this programme will find widespread use, interest, and generate impact, across the wider academic community beyond clinical science, notably in biosensors, clinical microbiology, microfluidics, AMR, and bionanotechnology (see 'Academic Beneficiaries for more details).
5 The PDRAs on the programme will benefit from the training and development opportunities offered through this challenging interdisciplinary programme. The project will bring together scientists from a wide range of backgrounds with industry and clinical end-users, therefore benefitting the PDRAs through networking opportunities, and significantly increasing employability in academia, industry, and regulatory bodies, inter alia (see 'Academic Beneficiaries for more details).
IP arising from this research will be exploited fully through, e.g., direct licensing, or through University spin-out companies, as appropriate. The investigators have extensive experience in both approaches, e.g. the spin-out companies Relitect Ltd (co-founder Wälti) and Elisha Ltd (co-founder Millner) (both manufacturers of biosensor technologies), or the Adhiron license to Avacta Plc for commercial exploitation of Leeds' antibody mimetics (co-inventors McPherson, Tomlinson).
Organisations
- University of Leeds (Lead Research Organisation)
- Defence Science & Technology Laboratory (DSTL) (Collaboration)
- Community Pharmacy West Yorkshire (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Karolinska Institute (Collaboration)
- NHS Leeds West CCG (Collaboration)
- Nuffield Health Ltd (Collaboration)
- Leeds City Council (Collaboration)
- NHS Leeds North CCG (Collaboration)
- BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (Collaboration)
Publications
Adamson H
(2020)
Engineering Protein Switches for Rapid Diagnostic Tests.
in ACS sensors
Adamson H
(2019)
Affimer-Enzyme-Inhibitor Switch Sensor for Rapid Wash-free Assays of Multimeric Proteins.
in ACS sensors
Adamson H
(2022)
Rapid Quantification of C. difficile Glutamate Dehydrogenase and Toxin B (TcdB) with a NanoBiT Split-Luciferase Assay.
in Analytical chemistry
Campbell E
(2023)
Enzyme - Switch sensors for therapeutic drug monitoring of immunotherapies.
in Biosensors & bioelectronics
Campbell E
(2024)
Therapeutic drug monitoring of immunotherapies with novel Affimer-NanoBiT sensor construct
in Sensors & Diagnostics
Chau C
(2024)
Automated Purification of DNA Origami with SPRI Beads.
in Small (Weinheim an der Bergstrasse, Germany)
Chau C
(2023)
Automated Purification of DNA Origami with SPRI Beads
Cocco P
(2021)
Integrating Early Economic Evaluation into Target Product Profile development for medical tests: advantages and potential applications.
in International journal of technology assessment in health care
Description | We are contributing to the development and implementation of Leeds City Council's 'Antimicrobial Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Membership of a guideline committee |
Description | Dean's Vacation Research Studentship |
Amount | £1,900 (GBP) |
Organisation | University of Leeds |
Sector | Academic/University |
Country | United Kingdom |
Start | 06/2020 |
End | 08/2020 |
Description | Development and evaluation of a short educational animation highlighting the importance of our healthy bacteria and how they are harmed by antibiotics |
Amount | £9,540 (GBP) |
Organisation | British Society for Antimicrobial Chemotherapy |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2018 |
End | 06/2021 |
Description | Impact Acceleration Account: Point-of-care assay for antibiotic therapeutic drug monitoring |
Amount | £55,000 (GBP) |
Organisation | University of Leeds |
Sector | Academic/University |
Country | United Kingdom |
Start | 12/2023 |
End | 04/2024 |
Description | Meropenem therapeutic drug monitoring to reduce antimicrobial resistance: Analytical validity of a novel meropenem assay |
Amount | £622,819 (GBP) |
Funding ID | NIHR205511 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 12/2023 |
End | 11/2026 |
Description | Multiplexed AKI biomarker detection with a single molecule biosensor |
Amount | £299,971 (GBP) |
Funding ID | EP/W004933/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 12/2023 |
Description | National PhD Training Programme in Antimicrobial Resistance Research |
Amount | £118,000 (GBP) |
Funding ID | MRF-145-0004-TPG-AVISO-S-C0705 |
Organisation | Medical Research Council (MRC) |
Department | Medical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2018 |
End | 09/2022 |
Description | Rapid immunoassay to diagnose seroconversion and immunity against SARS-CoV-2 |
Amount | £15,000 (GBP) |
Funding ID | Impact Acceleration Account |
Organisation | University of Leeds |
Sector | Academic/University |
Country | United Kingdom |
Start | 06/2020 |
End | 12/2020 |
Description | University of Leeds-Industry Engagement Academy |
Amount | £5,000 (GBP) |
Organisation | University of Leeds |
Sector | Academic/University |
Country | United Kingdom |
Start | 07/2018 |
End | 07/2019 |
Title | BLA-BLIP |
Description | An affimer-enzyme-inhibitor switch sensor to quantify protein targets in biological samples, with applications in point of care testing and/or infection diagnostics |
Type Of Material | Technology assay or reagent |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | Publication: Adamson, H.; Ajayi, M. O.; Campbell, E.; Brachi, E.; Tiede, C.; Tang, A. A.; Adams, T. L.; Ford, R.; Davidson, A.; Johnson, M. Affimer-Enzyme-Inhibitor Switch Sensor for Rapid Wash-free Assays of Multimeric Proteins. ACS Sens. 2019, 4 (11), 3014- 3022, |
Title | CDI NanoBiTBiP assay |
Description | An ultrasensitive assay to detect GDH and Toxin B for the accurate detection of Clostridioides difficile in clinical (faecal) samples |
Type Of Material | Technology assay or reagent |
Year Produced | 2022 |
Provided To Others? | Yes |
Impact | Publication: Adamson, H., Ajayi, M. O., Gilroy, K. E., McPherson, M., Tomlinson, D. C., Jeuken, L., J., C Rapid Quantification of C. difficile Glutamate Dehydrogenase and Toxin B (TcdB) with a NanoBiT Split-Luciferase Assay; Analytical Chemistry. 2022, 94 (23), 8156-8163 |
Title | Questionnaire to identify clinical needs in the diagnosis of C.difficile infection |
Description | The purpose of the questionnaire is to gain an understanding of clinical problems affecting available diagnostic tests for Clostridioides difficile (C.difficile) infection. The questionnaire was made available to end users of C. difficile diagnostic tests, both in primary and secondary care. |
Type Of Material | Model of mechanisms or symptoms - human |
Year Produced | 2021 |
Provided To Others? | No |
Impact | A manuscript is being written up for publication. |
Title | Clinical needs in the diagnosis of C.difficile infection |
Description | A questionnaire has been developed to gain an understanding of clinical problems affecting available diagnostic tests for Clostridioides difficile (C.difficile) infection. End users of C. difficile diagnostic tests, both in primary and secondary care have accessed the questionnaire. 48 responses have been received. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | No |
Impact | A manuscript is being written up for publication. |
URL | https://ridamr.leeds.ac.uk/news/questionnaire-to-identify-clinical-needs-in-the-diagnosis-of-c-diffi... |
Title | Dataset for Automated Purification of DNA Origami with SPRI Beads |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
URL | https://archive.researchdata.leeds.ac.uk/1190/ |
Title | Methods for developing Target Product Profiles for medical tests: a systematic review |
Description | This dataset contains the results of the data extraction as part of this systematic review. From each included Target Product Profile (TPP), we reported 1) input sources 2) stakeholders involved 3) decision-making process 4) results of the transparency assessment. Additionally, we provided a list of the test characteristics featured in the TPPs included in this systematic review. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | http://archive.researchdata.leeds.ac.uk/654/ |
Title | Methods for developing Target Product Profiles for medical tests: a systematic review [V2] |
Description | This dataset contains the results of the data extraction as part of this systematic review. From each included study, we reported 1) input sources 2) stakeholders involved 3) decision-making process 4) test characteristics featured in the Target Product Profile (TPP) under evaluation. Additionally, for each included study we conducted a transparency assessment.Two additional worksheets contains information on (i) how the price and diagnostic accuracy values were estimated; and (ii) what type of technology is described in the TPP. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
URL | https://archive.researchdata.leeds.ac.uk/999/ |
Description | DSTL studentship |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Country | United Kingdom |
Sector | Public |
PI Contribution | The DSTL provide funding to a studentship which is aligned to the programme. Laboratory research outputs (assay developments and optimisation) have been used by this studentship. |
Collaborator Contribution | Expertise and knowledge |
Impact | No outputs yet. |
Start Year | 2019 |
Description | Leeds City Council Antimicrobial Stewardship Committee |
Organisation | Community Pharmacy West Yorkshire |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | We are part of this committee as rapid infection diagnostics will be crucial in helping with appropriate antibiotic prescribing by clinicians and preventing the emergence of drug resistant infections. We and the Council are combining resources to help each other in our aims. We are contributing in developing their 'Antimicrobials Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. We contribute to quarterly meetings and present the progress made within our research programme for the development of the rapid infection diagnostic device. We are aiding in promotion of the AMR stewardship activities of Leeds City Council by placing news links to their activities such as the 'seriously resistant' campaign on our Programme webpage. We are also promoting Public Health England's (PHE) activities by placing links to their 'Keep Antibiotics Working' TV Ad video as well as their 'e-Bug' resource (fun games and teaching resources about microbes and antibiotics for teachers and pupils) which aims to reduce the incidence of antibiotic resistance across Europe by educating future generations. As part of implementing the AMR plan across Leeds, one of the priorities is educating children and young people regarding appropriate use of antibiotics. We are thus part of the 'AMR messages within schools' sub-committee to develop initiatives and determine what can practically be implemented within schools as ways of targeting young people. We have developed a lesson plan with Abbey Grange School in Leeds to promote the use of point of care diagnostic testing in determining bacterial vs. viral infection and a general introduction about good antibiotic use. The lesson plan has been devised and will be undertaken by one our post doctoral research associates. |
Collaborator Contribution | Being part of this committee has placed us in direct contact with key partners that will be crucial to the rolling out of our diagnostic device. They support our programme and the Leeds Care Commissioning Groups as well as Public Health England will facilitate and be an accelerator for bringing diagnostic tests to key end-users: primary care/GPs, pharmacists, dentists ad other key health protection personnel within the City. This committee has provided us with direct access to key individuals. |
Impact | We are part of Leeds City Council's 'rolling AMR messages to schools' campaign. We have generated a lesson plan for year 10 pupils for a secondary school in the City, which will be rolled out throughout all schools in the Leeds area. This lesson will inform students of issues related to antibiotic resistance and how antibiotic misuse has a role in in the development of resistance. We will introduce how a rapid diagnostic device, that discriminates between bacterial and viral infection, will help GPs with appropriate antibiotic prescribing. |
Start Year | 2017 |
Description | Leeds City Council Antimicrobial Stewardship Committee |
Organisation | Leeds City Council |
Country | United Kingdom |
Sector | Public |
PI Contribution | We are part of this committee as rapid infection diagnostics will be crucial in helping with appropriate antibiotic prescribing by clinicians and preventing the emergence of drug resistant infections. We and the Council are combining resources to help each other in our aims. We are contributing in developing their 'Antimicrobials Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. We contribute to quarterly meetings and present the progress made within our research programme for the development of the rapid infection diagnostic device. We are aiding in promotion of the AMR stewardship activities of Leeds City Council by placing news links to their activities such as the 'seriously resistant' campaign on our Programme webpage. We are also promoting Public Health England's (PHE) activities by placing links to their 'Keep Antibiotics Working' TV Ad video as well as their 'e-Bug' resource (fun games and teaching resources about microbes and antibiotics for teachers and pupils) which aims to reduce the incidence of antibiotic resistance across Europe by educating future generations. As part of implementing the AMR plan across Leeds, one of the priorities is educating children and young people regarding appropriate use of antibiotics. We are thus part of the 'AMR messages within schools' sub-committee to develop initiatives and determine what can practically be implemented within schools as ways of targeting young people. We have developed a lesson plan with Abbey Grange School in Leeds to promote the use of point of care diagnostic testing in determining bacterial vs. viral infection and a general introduction about good antibiotic use. The lesson plan has been devised and will be undertaken by one our post doctoral research associates. |
Collaborator Contribution | Being part of this committee has placed us in direct contact with key partners that will be crucial to the rolling out of our diagnostic device. They support our programme and the Leeds Care Commissioning Groups as well as Public Health England will facilitate and be an accelerator for bringing diagnostic tests to key end-users: primary care/GPs, pharmacists, dentists ad other key health protection personnel within the City. This committee has provided us with direct access to key individuals. |
Impact | We are part of Leeds City Council's 'rolling AMR messages to schools' campaign. We have generated a lesson plan for year 10 pupils for a secondary school in the City, which will be rolled out throughout all schools in the Leeds area. This lesson will inform students of issues related to antibiotic resistance and how antibiotic misuse has a role in in the development of resistance. We will introduce how a rapid diagnostic device, that discriminates between bacterial and viral infection, will help GPs with appropriate antibiotic prescribing. |
Start Year | 2017 |
Description | Leeds City Council Antimicrobial Stewardship Committee |
Organisation | NHS Leeds North CCG |
Country | United Kingdom |
Sector | Public |
PI Contribution | We are part of this committee as rapid infection diagnostics will be crucial in helping with appropriate antibiotic prescribing by clinicians and preventing the emergence of drug resistant infections. We and the Council are combining resources to help each other in our aims. We are contributing in developing their 'Antimicrobials Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. We contribute to quarterly meetings and present the progress made within our research programme for the development of the rapid infection diagnostic device. We are aiding in promotion of the AMR stewardship activities of Leeds City Council by placing news links to their activities such as the 'seriously resistant' campaign on our Programme webpage. We are also promoting Public Health England's (PHE) activities by placing links to their 'Keep Antibiotics Working' TV Ad video as well as their 'e-Bug' resource (fun games and teaching resources about microbes and antibiotics for teachers and pupils) which aims to reduce the incidence of antibiotic resistance across Europe by educating future generations. As part of implementing the AMR plan across Leeds, one of the priorities is educating children and young people regarding appropriate use of antibiotics. We are thus part of the 'AMR messages within schools' sub-committee to develop initiatives and determine what can practically be implemented within schools as ways of targeting young people. We have developed a lesson plan with Abbey Grange School in Leeds to promote the use of point of care diagnostic testing in determining bacterial vs. viral infection and a general introduction about good antibiotic use. The lesson plan has been devised and will be undertaken by one our post doctoral research associates. |
Collaborator Contribution | Being part of this committee has placed us in direct contact with key partners that will be crucial to the rolling out of our diagnostic device. They support our programme and the Leeds Care Commissioning Groups as well as Public Health England will facilitate and be an accelerator for bringing diagnostic tests to key end-users: primary care/GPs, pharmacists, dentists ad other key health protection personnel within the City. This committee has provided us with direct access to key individuals. |
Impact | We are part of Leeds City Council's 'rolling AMR messages to schools' campaign. We have generated a lesson plan for year 10 pupils for a secondary school in the City, which will be rolled out throughout all schools in the Leeds area. This lesson will inform students of issues related to antibiotic resistance and how antibiotic misuse has a role in in the development of resistance. We will introduce how a rapid diagnostic device, that discriminates between bacterial and viral infection, will help GPs with appropriate antibiotic prescribing. |
Start Year | 2017 |
Description | Leeds City Council Antimicrobial Stewardship Committee |
Organisation | NHS Leeds West CCG |
Country | United Kingdom |
Sector | Public |
PI Contribution | We are part of this committee as rapid infection diagnostics will be crucial in helping with appropriate antibiotic prescribing by clinicians and preventing the emergence of drug resistant infections. We and the Council are combining resources to help each other in our aims. We are contributing in developing their 'Antimicrobials Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. We contribute to quarterly meetings and present the progress made within our research programme for the development of the rapid infection diagnostic device. We are aiding in promotion of the AMR stewardship activities of Leeds City Council by placing news links to their activities such as the 'seriously resistant' campaign on our Programme webpage. We are also promoting Public Health England's (PHE) activities by placing links to their 'Keep Antibiotics Working' TV Ad video as well as their 'e-Bug' resource (fun games and teaching resources about microbes and antibiotics for teachers and pupils) which aims to reduce the incidence of antibiotic resistance across Europe by educating future generations. As part of implementing the AMR plan across Leeds, one of the priorities is educating children and young people regarding appropriate use of antibiotics. We are thus part of the 'AMR messages within schools' sub-committee to develop initiatives and determine what can practically be implemented within schools as ways of targeting young people. We have developed a lesson plan with Abbey Grange School in Leeds to promote the use of point of care diagnostic testing in determining bacterial vs. viral infection and a general introduction about good antibiotic use. The lesson plan has been devised and will be undertaken by one our post doctoral research associates. |
Collaborator Contribution | Being part of this committee has placed us in direct contact with key partners that will be crucial to the rolling out of our diagnostic device. They support our programme and the Leeds Care Commissioning Groups as well as Public Health England will facilitate and be an accelerator for bringing diagnostic tests to key end-users: primary care/GPs, pharmacists, dentists ad other key health protection personnel within the City. This committee has provided us with direct access to key individuals. |
Impact | We are part of Leeds City Council's 'rolling AMR messages to schools' campaign. We have generated a lesson plan for year 10 pupils for a secondary school in the City, which will be rolled out throughout all schools in the Leeds area. This lesson will inform students of issues related to antibiotic resistance and how antibiotic misuse has a role in in the development of resistance. We will introduce how a rapid diagnostic device, that discriminates between bacterial and viral infection, will help GPs with appropriate antibiotic prescribing. |
Start Year | 2017 |
Description | Leeds City Council Antimicrobial Stewardship Committee |
Organisation | Nuffield Health Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | We are part of this committee as rapid infection diagnostics will be crucial in helping with appropriate antibiotic prescribing by clinicians and preventing the emergence of drug resistant infections. We and the Council are combining resources to help each other in our aims. We are contributing in developing their 'Antimicrobials Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. We contribute to quarterly meetings and present the progress made within our research programme for the development of the rapid infection diagnostic device. We are aiding in promotion of the AMR stewardship activities of Leeds City Council by placing news links to their activities such as the 'seriously resistant' campaign on our Programme webpage. We are also promoting Public Health England's (PHE) activities by placing links to their 'Keep Antibiotics Working' TV Ad video as well as their 'e-Bug' resource (fun games and teaching resources about microbes and antibiotics for teachers and pupils) which aims to reduce the incidence of antibiotic resistance across Europe by educating future generations. As part of implementing the AMR plan across Leeds, one of the priorities is educating children and young people regarding appropriate use of antibiotics. We are thus part of the 'AMR messages within schools' sub-committee to develop initiatives and determine what can practically be implemented within schools as ways of targeting young people. We have developed a lesson plan with Abbey Grange School in Leeds to promote the use of point of care diagnostic testing in determining bacterial vs. viral infection and a general introduction about good antibiotic use. The lesson plan has been devised and will be undertaken by one our post doctoral research associates. |
Collaborator Contribution | Being part of this committee has placed us in direct contact with key partners that will be crucial to the rolling out of our diagnostic device. They support our programme and the Leeds Care Commissioning Groups as well as Public Health England will facilitate and be an accelerator for bringing diagnostic tests to key end-users: primary care/GPs, pharmacists, dentists ad other key health protection personnel within the City. This committee has provided us with direct access to key individuals. |
Impact | We are part of Leeds City Council's 'rolling AMR messages to schools' campaign. We have generated a lesson plan for year 10 pupils for a secondary school in the City, which will be rolled out throughout all schools in the Leeds area. This lesson will inform students of issues related to antibiotic resistance and how antibiotic misuse has a role in in the development of resistance. We will introduce how a rapid diagnostic device, that discriminates between bacterial and viral infection, will help GPs with appropriate antibiotic prescribing. |
Start Year | 2017 |
Description | Leeds City Council Antimicrobial Stewardship Committee |
Organisation | Public Health England |
Country | United Kingdom |
Sector | Public |
PI Contribution | We are part of this committee as rapid infection diagnostics will be crucial in helping with appropriate antibiotic prescribing by clinicians and preventing the emergence of drug resistant infections. We and the Council are combining resources to help each other in our aims. We are contributing in developing their 'Antimicrobials Stewardship Plan 2017/20' document which has 4 specific priorities: Priority 1 - To raise awareness of antibiotic resistance targeting public, professional, targeted and vulnerable groups; Priority 2 - To utilise local Surveillance data to improve prescribing practice across the whole health economy; Priority 3 - To improve Appropriate Consumption of antibiotics across the whole health economy; and Priority 4 - To Improve Quality Prescribing. We contribute to quarterly meetings and present the progress made within our research programme for the development of the rapid infection diagnostic device. We are aiding in promotion of the AMR stewardship activities of Leeds City Council by placing news links to their activities such as the 'seriously resistant' campaign on our Programme webpage. We are also promoting Public Health England's (PHE) activities by placing links to their 'Keep Antibiotics Working' TV Ad video as well as their 'e-Bug' resource (fun games and teaching resources about microbes and antibiotics for teachers and pupils) which aims to reduce the incidence of antibiotic resistance across Europe by educating future generations. As part of implementing the AMR plan across Leeds, one of the priorities is educating children and young people regarding appropriate use of antibiotics. We are thus part of the 'AMR messages within schools' sub-committee to develop initiatives and determine what can practically be implemented within schools as ways of targeting young people. We have developed a lesson plan with Abbey Grange School in Leeds to promote the use of point of care diagnostic testing in determining bacterial vs. viral infection and a general introduction about good antibiotic use. The lesson plan has been devised and will be undertaken by one our post doctoral research associates. |
Collaborator Contribution | Being part of this committee has placed us in direct contact with key partners that will be crucial to the rolling out of our diagnostic device. They support our programme and the Leeds Care Commissioning Groups as well as Public Health England will facilitate and be an accelerator for bringing diagnostic tests to key end-users: primary care/GPs, pharmacists, dentists ad other key health protection personnel within the City. This committee has provided us with direct access to key individuals. |
Impact | We are part of Leeds City Council's 'rolling AMR messages to schools' campaign. We have generated a lesson plan for year 10 pupils for a secondary school in the City, which will be rolled out throughout all schools in the Leeds area. This lesson will inform students of issues related to antibiotic resistance and how antibiotic misuse has a role in in the development of resistance. We will introduce how a rapid diagnostic device, that discriminates between bacterial and viral infection, will help GPs with appropriate antibiotic prescribing. |
Start Year | 2017 |
Description | Rapid Infection Diagnostic Device: Advisory Committee |
Organisation | British Society for Antimicrobial Chemotherapy |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | The president of the British Society of Antimicrobial Chemotherapy and the Head of Pharmacy Development of the Leeds CCG have formed part of our advisory group for our consortium along with a pharmacist, community nurse and GP to aid determining patient and GP acceptability and feasibility of use of our device in primary care. |
Collaborator Contribution | Leeds CCG has placed us in to direct contact with Leeds GP Federation and so a 'test bed' for our device in primary care. They have advised us of possible routes to roll out and trials of our device.They have advised us of the minimum clinical criteria for our device for possible roll out. |
Impact | We have a devised a pathway for our device for use in primary care, in particular the route defined would be via GP surgeries with an integral pharmacy, so to act as a triage for appointments. The President of BSAC had placed our research activities to the attention of the incoming Chief Medical Officer to gain advice on our device. |
Start Year | 2019 |
Description | Rapid Infection Diagnostic Device: Advisory Committee |
Organisation | NHS Leeds West CCG |
Country | United Kingdom |
Sector | Public |
PI Contribution | The president of the British Society of Antimicrobial Chemotherapy and the Head of Pharmacy Development of the Leeds CCG have formed part of our advisory group for our consortium along with a pharmacist, community nurse and GP to aid determining patient and GP acceptability and feasibility of use of our device in primary care. |
Collaborator Contribution | Leeds CCG has placed us in to direct contact with Leeds GP Federation and so a 'test bed' for our device in primary care. They have advised us of possible routes to roll out and trials of our device.They have advised us of the minimum clinical criteria for our device for possible roll out. |
Impact | We have a devised a pathway for our device for use in primary care, in particular the route defined would be via GP surgeries with an integral pharmacy, so to act as a triage for appointments. The President of BSAC had placed our research activities to the attention of the incoming Chief Medical Officer to gain advice on our device. |
Start Year | 2019 |
Description | Transpeptidase based diagnostic |
Organisation | Karolinska Institute |
Department | Department of Neuroscience |
Country | Sweden |
Sector | Academic/University |
PI Contribution | Acknowledgement in publications and outputs |
Collaborator Contribution | Material provision and know how. The sample provided is of no commercial value, but would cost in the order of £4000 - £5000 if commercially sourced. |
Impact | No outputs to date |
Start Year | 2021 |
Title | Affimer-enzyme-inhibitor switch assay |
Description | We have developed a novel affimer-enzyme-inhibitor switch assay for a point-of-care application. The assay is rapid, using a simple wash-free assay format and is sensitive for the detection of C-reactive protein. We are exploring how this may be commercialised. |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2020 |
Development Status | Under active development/distribution |
Impact | Publication: Adamson, H.; Ajayi, M. O.; Campbell, E.; Brachi, E.; Tiede, C.; Tang, A. A.; Adams, T. L.; Ford, R.; Davidson, A.; Johnson, M.; McPherson, M. J.; Tomlinson, D. C.; Jeuken, L. J. C., Affimer-Enzyme-Inhibitor Switch Sensor for Rapid Wash-free Assays of Multimeric Proteins. ACS Sensors 2019, 4 (11), 3014-3022. |
Title | Diagnostic tool for therapeutic drug monitoring |
Description | We have developed a point-of-care assay for antibiotic therapeutic drug monitoring (meropenem). The assay is rapid, using a simple wash-free assay format and is sensitive across the entire clinically relevant range. We are carrying out a validation study and exploring how this may be commercialised. |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2024 |
Development Status | Under active development/distribution |
Impact | The assay is still under development, a patent application will be filed in due course followed by a scientific publication. |
Title | Our Helpful Bacteria Animation |
Description | Funded jointly by the MRC AMR Programme and BSAC, we have produced a short stop frame animation film to help reduce public demand for antibiotics and better inform patients. As part of a behavioural study, 200 adults watched the animation and 200 adults watched a control video. They completed questionnaires before and after viewing and the questionnaire completion was repeated after 6 weeks. The questionnaire was used to assess motivations for the use of antibiotics. |
Type | Therapeutic Intervention - Psychological/Behavioural |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2019 |
Development Status | Under active development/distribution |
Impact | Audience reported change in views, opinions or behaviours |
URL | https://youtu.be/r_50QNX0-t0 |
Description | "Early economic modelling to inform a Target Product Profile. A case study of a rapid test for Clostridioides difficile infection" at the Methods for the Economic Evaluation of Diagnostics (MEED) Research Forum |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation by Paola Cocco with a focus on the early economic model informing minimum specifications and maximum costs for a hypothetical rapid test for Clostridioides difficile infection. |
Year(s) Of Engagement Activity | 2022 |
URL | http://newcastle.mic.nihr.ac.uk/methods-for-the-economic-evaluation-of-diagnostics-research-forum-20... |
Description | "Workshop on Target Product Profiles for tests and in-vitro diagnostics" at the GBi2M Bootcamp (Germany) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Presentation at a workshop on TPPs by Paola Cocco for tests, their value for developers, common methods and application to a case study example |
Year(s) Of Engagement Activity | 2023 |
Description | 1.30pm, 6.30pm and 10.30 pm BBC Yorkshire news (lead story): Christoph Walti |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professor Christoph Walti explained that antibiotics can treat bacterial infections only, and discussed the importance of the development a diagnostic device to help GPs determine if an infection is bacterial or viral to help them prescribe antibiotics appropriately. He discussed the activities of the research programme, facilities at Leeds were shown as well as a description of the technology that the device will be based on. |
Year(s) Of Engagement Activity | 2017 |
Description | 11am - BBC Radio 5 Live: Lars Jeuken interviewd by Adrian Charles |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professor Jeuken discussed in an interview the problem with drug resistant infections associated with antibiotic misuse. He promoted the activities of the research programme and explained that a diagnostic device was being generated to differentiate between bacterial and viral infections. This would help GPs decide if antibiotics were appropriate i.e.. if the infection was bacterial. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.bbc.co.uk/programmes/b099vz8n#playt=*1*0*0 |
Description | 5 News Tonight : 24th January, 18:46 PM GMT FIVE 24th January - Broadcast Professor Lars Jeuken (Astbury) was interviewed about how Leeds researchers are developing diagnostic devices so that GPs can test blood and find out almost instantly if you have a virus or a bacterial infection. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | FIVE LIVE, 24th January 2019 - Broadcast Professor Lars Jeuken (Astbury) was interviewed about how Leeds researchers are developing diagnostic devices so that GPs can test blood and find out almost instantly if you have a virus or a bacterial infection. |
Year(s) Of Engagement Activity | 2018 |
Description | 6pm Made In Leeds TV Channel: Interview with Christoph Walti |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professor Walti discussed the activities of this research programme and the different technologies that the device will be based on. He the importance of a diagnostic device to help GPs determine if an infection is bacterial or viral to help them prescribe antibiotics appropriately. |
Year(s) Of Engagement Activity | 2017 |
Description | 7.30pm BBC Yorkshire and Lincolnshire Inside Out documentary programme (lead story) Christoph Walti, Mark Wilcox. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | 7.30pm BBC Yorkshire and Lincolnshire 'Inside Out' documentary programme (lead story) - full 10 minute documentary piece charting the development of the device and featuring Lord O'Neill, Dame Sally Davies, the Chief Medical Officer and Helen McAuslane from Public Health England. Professor Christoph Walti and Professor Mark Wilcox explained that antibiotics can treat bacterial infections only, and the importance of a diagnostic device to help GPs determine if an infection is bacterial or viral to help them prescribe antibiotics appropriately. They discussed the activities of the research programme, facilities at Leeds were shown as well as a description of the technology that the device will be based on. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.bbc.co.uk/news/av/uk-england-leeds-41692214/antibiotic-resistance-leeds-scientists-develo... |
Description | 7.35am: BBC Radio Humberside interview about antibiotic resistance and diagnostics - Lars Jeuken |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Lars Jeuken gave an interview about the issues of rising drug resistant infections and how infection diagnostics will help prevent these. He promoted the activities of our research programme. |
Year(s) Of Engagement Activity | 2017 |
Description | AMR Seminar - Accelerating Development of Infection Diagnostics for Patient Management and Reduction of Antibiotic Misuse |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Christoph Walti gave a 20 minute seminar about the MRC funded AMR Programme. |
Year(s) Of Engagement Activity | 2021 |
Description | Acute Kidney Injury & Sepsis: Unmet Clinical Needs Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | The workshop was chaired by Professor Mark Wilcox (and Dr Andrew Lewington) and brought together invited clinicians, healthcare professionals, academics, patients and industry partners to explore the unmet clinical needs in diagnosing Sepsis including antimicrobial resistance (and Acute Kidney Injury). By highlighting the current limitations in these areas the workshop explored how in vitro diagnostics might address these gaps. |
Year(s) Of Engagement Activity | 2019 |
Description | Antimicrobial Resistance Workshop Programme 25 January 2017, St Hugh's College, Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Mark Wilcox (Co-investigator), University of Leeds was an invited speaker and presented 'The clinical need for better antimicrobial resistance related diagnostics'. The workshop offered clinicians in key clinical areas (urinary tract and respiratory infections, sepsis), the opportunity to meet and discuss what type of diagnostics are needed to manage the challenge of antimicrobial resistance. It allowed the sharing of knowledge between practitioners and industrial partners developing infection diagnostic point of care devices. Key industrial perspectives were provided by British In Vitro Diagnostics Association. NICE led discussions on the challenge of AMR and what types of diagnostics are needed to manage the challenge of AMR. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.community.healthcare.mic.nihr.ac.uk/reports-and-resources/amr-workshop-2017 |
Description | Astbury Conversation, public engagement event, April 2018. |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This academic symposium which includes prestigious talks, selected presentations and poster sessions is designed to give an insight into life in molecular detail - for researchers wanting to know about the latest developments. It aims to bring together leading researchers from across the globe to discuss the most recent progress in the field of structural molecular biology in its broadest sense. It is also a public engagement event, showcasing some of the University's research, followed by a wine reception. |
Year(s) Of Engagement Activity | 2018 |
URL | https://astburyconversation.leeds.ac.uk/ehome/index.php?eventid=200183132& |
Description | BBC Breakfast TV: Christoph Walti |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Prof Christoph Walti discussed in an interview the problem with drug resistant infections associated with antibiotic misuse. He promoted the activities of the research programme and discussed that a diagnostic device was being developed to differentiate between bacterial and viral infections to help GPs decide if antibiotics were appropriate i.e. if the infection was bacterial. |
Year(s) Of Engagement Activity | 2017 |
Description | BBSRC Sparking Innovation Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Poster presentation by Tim Luxton; A novel carbapenem antibiotic assay for therapeutic drug monitoring. |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.ukri.org/events/bbsrc-sparking-innovation-conference/ |
Description | BSAC conference - December 21 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Timothy Luxton (PhD Student) attended the BSAC winter conference 2021 to deliver an oral presentation entitled: A systematic review of the effect of therapeutic drug monitoring on patient health outcomes during treatment with penicillins and a poster presentation: Timothy Luxton, Natalie King, Christoph Wälti, Lars Jeuken, Jonathan Sandoe, O04 A systematic review of the effect of therapeutic drug monitoring on patient health outcomes during treatment with penicillins, JAC-Antimicrobial Resistance, Volume 4, Issue Supplement_1, February 2022, dlac003.003 Oral + poster presentation |
Year(s) Of Engagement Activity | 2021 |
Description | Café Scientific, Chapel Allerton, Leeds: 21 November 8pm, at Seven Arts in Chapel Allerton |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Prof Lars Jeuken & Dr Jonathan Sandoe (co-investigators), spoke at a well-attended discussion on antimicrobial resistance at the 'Café Scientifique' event with a lively discussion afterwards. Both gave an informal short talk on antibiotic resistant infections, how they come about, the difficulties of diagnosing infections and how rapid diagnostics might help to reduce prescriptions of antibiotics. The talk was followed by an hour of question & answer session. Participants raised questions on how taking antibiotics inappropriately can have negative side effects, the difference between viral and bacterial infections (and antibiotics vs antivirals), the problems with detecting infections currently and how biomarkers can help distinguish between viral and bacterial infections. There was in particular a long discussion on 'good bacteria' that form part of the natural human biota and 'bad bacteria' that (can) cause infections and how antibiotics work on both. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.cafe-sci.org.uk/?page_id=13 |
Description | Cancer Research UK Virtual Spotlight "Taking forward the ED&D Roadmap: A Spotlight on Target Product Profiles (TPPs) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Paola Cocco provided an overview of the typical methods and development of Target Product Profiles for medical tests based on the findings of PhD. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.cancerresearchuk.org/health-professional/diagnosis/early-diagnosis-initiative/early-diag... |
Description | Construction of our Leeds antimicrobial resistance research programme webpage. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | A webpage was constructed to outline our research programme on diagnostics for AMR research. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.amr.leeds.ac.uk |
Description | Developing a framework based on early economic evaluation to inform Target Product Profiles for new diagnostic tests |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other audiences |
Results and Impact | Presentation by Paola Cocco at a seminar, focussing on the early economic model informing minimum specifications and maximum costs for a hypothetical rapid test for Clostridioides difficile infection |
Year(s) Of Engagement Activity | 2022 |
URL | http://www.exeter.ac.uk/news/events/details/index.php?event=11851 |
Description | Discovery Zone @ University of Leeds |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | 60 pupils attended for a school science fair to the university, where Declan Kohl (PhD student) delivered a stall on enzyme structure and activity. This sparked questions and discussion afterwards on the enzyme used and how they are specific to individual substrates, and the schools reported increased interest in related subject areas. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.moortown.leeds.sch.uk/blog/2019/04/08/discovery-zone-at-leeds-university/ |
Description | Electronics for Healthcare |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation by Christoph Walti on current research and participation in a UKRI funded network workshop, which will inform a report for EPSRC on future priorities and activities. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.eventbrite.co.uk/e/electronics-for-healthcare-tickets-440883744147 |
Description | GP focus group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | End user feedback was carried out with GP practice staff through a focus group, facilitated by Brainbox Research Ltd. Participants included GPs (n=4) and Practice Nurses (n=2) from 6 CCGs across England. The purpose of the focus group was to understand the value of a point of care test that is able to distinguish between bacterial and viral infections. Specifically, the participants were asked when they would use the test, how they would use the test, how the test might add value, the barriers and drivers for the test's use and characteristics desired within the test design. A follow up survey was circulated to participants to request feedback on which conditions the test might be useful for and any final comments. The report generated by Brainbox Research Ltd has led to further discussion regarding the future direction of the end user engagement work. |
Year(s) Of Engagement Activity | 2021 |
Description | Health Economics' Study Group (HESG) - University of Cambridge |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Attendance and oral presentation at the HESG, July 2021. Paola Cocco presented "What properties should a hypothetical point-of-care test (POCT) for Clostridioides difficile infection (CDI) possess. Early economic modelling capturing capacity constraints to inform a Target Product Profile (TPP). |
Year(s) Of Engagement Activity | 2021 |
URL | https://hesg.org.uk/meetings/summer-2021-university-of-cambridge/ |
Description | Health and Hygiene Workshops |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | We commissioned the Health and Well Being Service at Leeds City Council to deliver workshops to primary schools in high antibiotic prescribing areas in West Yorkshire. By the end of the session children can: 1) Explain key terms in relation to hygiene and infection 2) Explain why hand washing is important in preventing the spread of infection/s. 3) Provide a basic explanation of why, when and how medicines (including antibiotics) are used and the importance of using them correctly. |
Year(s) Of Engagement Activity | 2019 |
Description | International Men's Day Meeting Presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Professor Paul Millner talked about antimicrobial resistance and other health issues. |
Year(s) Of Engagement Activity | 2019 |
Description | Leeds Creative Labs -Bradford Playhouse. Collaboration between the University of Leeds and the local creative and cultural industries of the North. Jack Goode |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Creative labs generates collaborations between academics and creative innovators to find new and inventive ways to showcase academic research and achieve broad public impact. Increase our understanding of how the arts and technology might inform and support research relevant to contemporary society. The Cultural Institute at the University of Leeds matched Jono Gadsby from a theatre company 'Fused Imagination' with our PDRA, Jack Goode. Jack explained his research aims, the problem of antibiotic resistance, and the challenges of discriminating between viral versus bacterial infections. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.youtube.com/watch?v=NpNmvBTgTGU |
Description | Leeds Festival of Science 2017, 'Discovery Zone 2017' |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | As part of Leeds Festival of Science 2017, 450 pupils from primary and secondary school (KS2) attended the Discovery Zone during 2 day event. There was a wide range of stalls, including one from this AMR Programme, where pupils discovered interactively how bacteria become resistant to antibiotics and how antibiotics were important for health. We also promoted the idea of 'good bacteria' and 'bad bacteria'. We were keen to make clear that taking antibiotics was not bad, but should be taken on your doctor's advice. There was a discussion session so pupils could ask questions. All PDRAs from the programme were involved in this activity. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.leeds.ac.uk/forstaff/news/article/5780/discovery_zone_2017 |
Description | MRF AMR 4th Annual Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Attendance and presentation at the MRF AMR 4th Annual Conference entitled Engineering Protein Switches for the Rapid, Point of Care Detection of Infection Biomarkers. Attendance enabled networking and discussion. |
Year(s) Of Engagement Activity | 2021 |
Description | MRF Seminar Series |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Panellist in the MRF Annual Conference 2021 Session 4 on Encountering AMR in the worlds we live in. There was an excellent and highly engaging discussion as the panel discussed creating a deeper understanding of the wider worlds we live in and where AMR might sit in, be produced by, or even shape these worlds. |
Year(s) Of Engagement Activity | 2021 |
Description | Nanobodies international conference - September 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Emma Campbell (PhD) student, delivered a poster presentation; expressing nanobodies in a multidomain enzyme switch platform. |
Year(s) Of Engagement Activity | 2021 |
Description | Oral presentation at the European Biosensor Symposium, Florence, February 2019. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Oral presentation: European Biosensor Symposium, Florence, February 2019. Hope Adamson, PDRA presented progress on our novel biosensor technology. The Symposium will cover all topics of biosensor research and will focus on: Technologies for innovative formats: miniaturized, implantable, non-invasive, disposable, single/multiarray biosensors, paper-diagnostics Bioengineered and biomimetic recognition elements (MIPs, aptamers, receptors, modified enzymes with increasing catalytic activity, |
Year(s) Of Engagement Activity | 2018,2019 |
URL | http://conferences.academicjournals.org/cat/biological-sciences/2nd-european-biosensor-symposium |
Description | PPIE Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | A meeting with 3 patients was organised to request feedback, comments and patient perspective on the development of a novel laboratory/point of care assay. A presentation was given and patients were given the opportunity to ask questions. The participants were enthusiastic about the concept of the test and felt that such a test would be valuable for patient care. A summary of the meeting was produced and circulated to attendees. |
Year(s) Of Engagement Activity | 2022 |
Description | Presentation on Rapid, Point of Care diagnostics for the reduction of AMR |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | At the National Annual AMR Conference, Declan Kohl (PhD student) presented a 10 minute presentation on his PhD project on rapid, point-of-care diagnostics to the conference audience of students, academics and industry professionals. It encompassed the strive for a test to distinguish between bacterial and viral infections to reduce antibiotic prescriptions. It sparked interest at his poster during in the conference and lead to interesting conversations with GPs about point of care CRP testing in their practices. |
Year(s) Of Engagement Activity | 2019 |
Description | Tackling Antibiotic Resistance: What Should Dental Teams Do? |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The animation our helpful bacteria, developed by Dr Jon Sandoe, has been used in a Massive Open Online Courses (MOOCs) entitled Tackling Antibiotic Resistance: What Should Dental Teams Do? The MOOC references the animation, which has been accessed by over 2000 people in over 100 countries. |
Year(s) Of Engagement Activity | 2020,2021,2022 |
URL | https://www.futurelearn.com/courses/tackling-antibiotic-resistance-dentists |
Description | The Discovery Zone at Leeds - an interactive science session for school children |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | We held a stall, educating children about bacterial and viral infections and the importance of good antibiotic use.We described our research via interactive activities. Approximately 500 school children (KS2) attended the event in a sports hall with 23 stalls and 94 academic staff - from Professors to PhD students. The goal of the event is to enable children to discover what university life is all about by meeting researchers and academics in the university premises. The aim is to break down barriers between those who are expectant of gaining higher education and those who believe it beyond their capabilities. Feedback from school staff, children and families is obtained. |
Year(s) Of Engagement Activity | 2018 |
Description | User centred design of a point of care test to detect bacterial or viral infection. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | We have been working with a design company to assess the care pathway for the point of care test for detecting bacterial or viral infection. User journeys have been produced for different clinical settings. We have initiated dialogue with Pharmacists and GPs. The next steps are to hold focus groups to discuss usability and blockers to market. |
Year(s) Of Engagement Activity | 2020 |
Description | West Yorkshire Humanist Society Presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Professor Lars Jeuken presented a public lecture/seminar titled "Infection diagnostics and the fight against antimicrobial resistance (drug resistant infections)". |
Year(s) Of Engagement Activity | 2019 |