Cortical Function in Visual Dependency in Patients with Chronic Dizziness
Lead Research Organisation:
Imperial College London
Department Name: Dept of Medicine
Abstract
In this application to the MRC for a research grant we intend to elucidate the basis for long term (= chronic) dizziness. Chronic dizziness is common, disabling and has significant social repercussions, with up 1/5 of patients in specialised hospital clinics giving up work as a result. It often starts with relatively trivial inner ear (= vestibular) disorders such as labyrinthitis (= vestibular neuritis) or common problems such as migraine. The problem is that it is difficult to predict which patients with such bening and usually self-limiting disorders will go on to develop long term symptoms. We have identified that patients with chronic dizziness are unusually sensitive to complex visual stimuli (= visually dependent) and that rehabilitation treatments adapting these patients to visual movement are effective. However, the underlying anatomical and functional basis of visual dependence in chronic dizziness are not known.
We propose to carry out studies applying state of the art brain imaging and physiological techniques in patients with acute (= recent, sudden onset) dizziness and in patients with chronic dizziness, as well as in healthy control subjects. The brain imaging techniques allow visualization of the cerebral cortical areas involved in the processing of visual and vestibular (=balance) stimuli. The neuro-physiological techniques probe the excitability of visual areas, in particular those areas that interact with vestibular areas. The imaging and physiological results will be correlated with questionnaire data of the actual symptoms in the patients so that the clinical significance of the basic (= physiological + imaging) findings can be ascertained. A specific hypothesis we have is that in patients with chronic dizziness and enhanced visual dependence, the normal inhibitory interaction between the visual and vestibular parts of the brain will be lost or attenuated. We will also see patients acutely (eg recruited in the emergency department) and followed up, to see the normal and abnormal process of recovery in well and poorly recovered patients, respectively. These findings would provide the basis for new treatments of these symptoms, including the use of non invasive modulation of cortical excitability with transcranial electrical stimulation.
We propose to carry out studies applying state of the art brain imaging and physiological techniques in patients with acute (= recent, sudden onset) dizziness and in patients with chronic dizziness, as well as in healthy control subjects. The brain imaging techniques allow visualization of the cerebral cortical areas involved in the processing of visual and vestibular (=balance) stimuli. The neuro-physiological techniques probe the excitability of visual areas, in particular those areas that interact with vestibular areas. The imaging and physiological results will be correlated with questionnaire data of the actual symptoms in the patients so that the clinical significance of the basic (= physiological + imaging) findings can be ascertained. A specific hypothesis we have is that in patients with chronic dizziness and enhanced visual dependence, the normal inhibitory interaction between the visual and vestibular parts of the brain will be lost or attenuated. We will also see patients acutely (eg recruited in the emergency department) and followed up, to see the normal and abnormal process of recovery in well and poorly recovered patients, respectively. These findings would provide the basis for new treatments of these symptoms, including the use of non invasive modulation of cortical excitability with transcranial electrical stimulation.
Technical Summary
Research objectives: To clarify the underlying neuroanatomical and neurophysiological basis of chronic dizziness, in particular the increased visual dependence observed in such patients.
Background: Chronic dizziness is extremely common in neurology, ENT (ORL), audiology and old-age medicine. Chronic dizziness usually evolves from preceding acute, attacks of vertigo (rotatory dizziness) of viral etiology (vestibular neuritis) or recurrent episodes of vertigo (Meniere's disease and vestibular migraine). However, why some but not all patients with acute/episodic vertigo end up with long term dizziness is not known. A specific component of such chronic dizziness is an increase in visual dependence, that is, high levels of reliance on visual input for spatial orientation and balance. These patients are dizzier in environments with moving or complex visual surroundings, a syndrome called visual vertigo or visually-induced dizziness. In previous MRC cycles we have shown that vestibular physiotherapy including visual motion desensitization improves clinical outcomes in chronic dizziness but still the underlying anatomy and physiology of this important phenomenon is unknown.
Methodology: We will measure vestibular patients' symptoms with questionnaires and visual dependence with validated psycho-pshysical techniques. We will correlate such results with novel findings from visuo-vestibular functional imaging (fMRI) and human neurosphysiology studies (transcranial magnetic stimulation). Imaging and phsyiological studies will explore the known inhibitory coupling between visual motion and vestibular areas in the brain. Experimental subjects will include acute vestibular patients + follow up, patients already with chronic dizziness and healthy controls.
Application & exploitation of results: Dissemination of findings to the relevant clinical community and development of targeted therapies, including rational physiotherapies and non invasive brain stimulation.
Background: Chronic dizziness is extremely common in neurology, ENT (ORL), audiology and old-age medicine. Chronic dizziness usually evolves from preceding acute, attacks of vertigo (rotatory dizziness) of viral etiology (vestibular neuritis) or recurrent episodes of vertigo (Meniere's disease and vestibular migraine). However, why some but not all patients with acute/episodic vertigo end up with long term dizziness is not known. A specific component of such chronic dizziness is an increase in visual dependence, that is, high levels of reliance on visual input for spatial orientation and balance. These patients are dizzier in environments with moving or complex visual surroundings, a syndrome called visual vertigo or visually-induced dizziness. In previous MRC cycles we have shown that vestibular physiotherapy including visual motion desensitization improves clinical outcomes in chronic dizziness but still the underlying anatomy and physiology of this important phenomenon is unknown.
Methodology: We will measure vestibular patients' symptoms with questionnaires and visual dependence with validated psycho-pshysical techniques. We will correlate such results with novel findings from visuo-vestibular functional imaging (fMRI) and human neurosphysiology studies (transcranial magnetic stimulation). Imaging and phsyiological studies will explore the known inhibitory coupling between visual motion and vestibular areas in the brain. Experimental subjects will include acute vestibular patients + follow up, patients already with chronic dizziness and healthy controls.
Application & exploitation of results: Dissemination of findings to the relevant clinical community and development of targeted therapies, including rational physiotherapies and non invasive brain stimulation.
Planned Impact
The beneficiaries from this research will be:
- Neuroscience research community: The changes induced in the brain by a peripheral vestibular lesion have always been one the best examples of lesion-induced neural plasticity. Our approach studies divergent modes of recovery following a vestibular lesion, a good outcome and a poor outcome leading to chronic dizziness and visually induced dizziness. Thus we would be expanding the horizon in this field of research and further human and animal research models may follow, turning a basic field of research into an applied one.
- Healthcare personnel: a rational basis to explain difficult symptoms in a large patient population is always welcome by healthcare practitioners, in this case in particular neurologists, ENT and audiology specialists, geriatritians, GPs and rehabilitation specialists (physiotherapists and audiologists dealing with dizzy patients).
- Healthcare resources: chronic dizziness is 'expensive'. There is a considerable waste of resources on this large patient population because patients are disatisfied and doctors worried that patients don't get better. As a result patients have unecessary expensive investigations, typically MRI/CT scans, EEG, and cross-specialist referrals, which are useless for the vast majority of these patients.
- Patients: patients will also benefit because one of the frustrating things about chronic dizziness is the general lack of knowledge by general physicians and consultants on this matter. Providing a rational basis for a complex clinical condition is always reassuring to patients, as they can understand the symptoms they experience. In addition, the findings will lead, without any doubt, to new treatments (usually targeted rehabilitation) for these patients. We often pioneer such treatment developments and actually hope to do so again during the next research cycle.
- Neuroscience research community: The changes induced in the brain by a peripheral vestibular lesion have always been one the best examples of lesion-induced neural plasticity. Our approach studies divergent modes of recovery following a vestibular lesion, a good outcome and a poor outcome leading to chronic dizziness and visually induced dizziness. Thus we would be expanding the horizon in this field of research and further human and animal research models may follow, turning a basic field of research into an applied one.
- Healthcare personnel: a rational basis to explain difficult symptoms in a large patient population is always welcome by healthcare practitioners, in this case in particular neurologists, ENT and audiology specialists, geriatritians, GPs and rehabilitation specialists (physiotherapists and audiologists dealing with dizzy patients).
- Healthcare resources: chronic dizziness is 'expensive'. There is a considerable waste of resources on this large patient population because patients are disatisfied and doctors worried that patients don't get better. As a result patients have unecessary expensive investigations, typically MRI/CT scans, EEG, and cross-specialist referrals, which are useless for the vast majority of these patients.
- Patients: patients will also benefit because one of the frustrating things about chronic dizziness is the general lack of knowledge by general physicians and consultants on this matter. Providing a rational basis for a complex clinical condition is always reassuring to patients, as they can understand the symptoms they experience. In addition, the findings will lead, without any doubt, to new treatments (usually targeted rehabilitation) for these patients. We often pioneer such treatment developments and actually hope to do so again during the next research cycle.
Organisations
- Imperial College London (Lead Research Organisation)
- UNIVERSITY OF OXFORD (Collaboration)
- National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) (Collaboration)
- University of Pisa (Collaboration)
- National and Kapodistrian University of Athens (Collaboration)
- University of Zurich (Collaboration)
- UNIVERSITY OF WESTMINSTER (Collaboration)
- Free University of Amsterdam (Collaboration)
- University of Antwerp (Collaboration)
- University of Perugia (Collaboration)
- Aix-Marseille University (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Ahmad H
(2015)
USING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO PROBE EFFECTS OF VISUAL MOTION ADAPTATION ON PRIMARY VISUAL CORTEX (V1) EXCITABILITY IN BILATERAL VESTIBULAR FAILURE (BVF) PATIENTS
in Journal of Neurology, Neurosurgery & Psychiatry
Ahmad H
(2017)
Downregulation of early visual cortex excitability mediates oscillopsia suppression.
in Neurology
Ahmad H
(2014)
Applications of neuromodulation to explore vestibular cortical processing; new insights into the effects of direct current cortical modulation upon pursuit, VOR and VOR suppression.
in Journal of vestibular research : equilibrium & orientation
Ahmad H
(2015)
Probing effects of visual motion adaptation on primary visual cortex (V1) excitability using Tms in Bilateral Vestibular Failure (Bvf) patients
in Journal of the Neurological Sciences
Ahmad H
(2015)
Are white matter abnormalities associated with "unexplained dizziness"?
in Journal of the neurological sciences
Ahmad H
(2018)
Clinical and Functional Characterization of a Missense ELF2 Variant in a CANVAS Family.
in Frontiers in genetics
Ahmad H
(2015)
Are white matter abnormalities a cause of "unexplained dizziness"?: A retrospective bi-centre study
in Journal of the Neurological Sciences
Anastasopoulos D
(2019)
Large gaze shift generation while standing: the role of the vestibular system.
in Journal of neurophysiology
Anastasopoulos D
(2015)
Fast gaze reorientations by combined movements of the eye, head, trunk and lower extremities.
in Experimental brain research
Anastasopoulos D
(2013)
Trunk bradykinesia and foveation delays during whole-body turns in spasmodic torticollis.
in Journal of neurology
Arshad Q
(2016)
Bidirectional Modulation of Numerical Magnitude.
in Cerebral cortex (New York, N.Y. : 1991)
Arshad Q
(2014)
Unidirectional visual motion adaptation induces reciprocal inhibition of human early visual cortex excitability.
in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Arshad Q
(2013)
Handedness-related cortical modulation of the vestibular-ocular reflex.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Arshad Q
(2015)
Role of handedness-related vestibular cortical dominance upon the vestibular-ocular reflex.
in Journal of neurology
Arshad Q
(2017)
Biased numerical cognition impairs economic decision-making in Parkinson's disease.
in Annals of clinical and translational neurology
Arshad Q
(2015)
Electrocortical therapy for motion sickness.
in Neurology
Arshad Q
(2019)
Interhemispheric control of sensory cue integration and self-motion perception.
in Neuroscience
Arshad Q
(2016)
Perceived state of self during motion can differentially modulate numerical magnitude allocation.
in The European journal of neuroscience
Arshad Q
(2013)
Separate attentional components modulate early visual cortex excitability.
in Cortex; a journal devoted to the study of the nervous system and behavior
Arshad Q
(2014)
Left cathodal trans-cranial direct current stimulation of the parietal cortex leads to an asymmetrical modulation of the vestibular-ocular reflex.
in Brain stimulation
Arshad Q
(2017)
Influence of biases in numerical magnitude allocation on human prosocial decision making.
in Journal of neurophysiology
Bednarczuk NF
(2017)
Inter-hemispheric control of vestibular thresholds.
in Brain stimulation
Bednarczuk NF
(2020)
Pathophysiological dissociation of the interaction between time pressure and trait anxiety during spatial orientation judgments.
in The European journal of neuroscience
Bednarczuk NF
(2018)
Vestibulo-cortical hemispheric dominance: The link between anxiety and the vestibular system?
in The European journal of neuroscience
Title | NeuroSci-Art Image competition |
Description | First prize in the Neurosci-art competition 2015. Now on permanent display in a college building and used on Brain Sciences / Centre for Clinical Translation web page. |
Type Of Art | Image |
Year Produced | 2013 |
Impact | none |
URL | http://www1.imperial.ac.uk/departmentofmedicine/divisions/brainsciences/translationalneuroscience_me... |
Description | Improved Treatment of Balance Disorders |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | This REF impact case collected several lines of evidence showing how the treatments we devised had been adopted worldwide, and were cited in government health policy documents. |
URL | http://impact.ref.ac.uk/CaseStudies/CaseStudy.aspx?Id=42200 |
Description | AMS Clinician Scientist Fellowship |
Amount | £700,000 (GBP) |
Organisation | Academy of Medical Sciences (AMS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Bequest from Dr Dix's estate |
Amount | £276,619 (GBP) |
Funding ID | WMCT_P51150 |
Organisation | Otto Dix Foundation |
Sector | Public |
Country | Germany |
Start | 02/2017 |
Description | EEG in small vessel white matter disease (BRC) |
Amount | £56,000 (GBP) |
Organisation | National Institute for Health Research |
Department | NIHR Imperial Biomedical Research Centre |
Sector | Public |
Country | United Kingdom |
Start | 06/2015 |
End | 03/2016 |
Description | MRes studentship |
Amount | £160,000 (GBP) |
Organisation | University of Chile |
Sector | Academic/University |
Country | Chile |
Start | 09/2016 |
End | 09/2020 |
Description | P18036 - Meniere's Society Project Grant |
Amount | £284,406 (GBP) |
Funding ID | P18036 |
Organisation | Ménière’s Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2008 |
End | 12/2015 |
Description | P51150 - Spatial orientation control |
Amount | £29,000 (GBP) |
Funding ID | p51150 |
Organisation | Imperial College London |
Department | Imperial College Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2016 |
Description | P52213 - CLRN Regis to the Barany Conf. |
Amount | £479 (GBP) |
Funding ID | p52213 |
Organisation | Imperial College Healthcare NHS Trust |
Sector | Hospitals |
Country | United Kingdom |
Start | 03/2014 |
End | 03/2015 |
Description | P53058 - Purchase of Frenzel glasses |
Amount | £2,200 (GBP) |
Funding ID | p53058 |
Organisation | Ménière’s Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2014 |
End | 03/2015 |
Description | PC3403 - IC TRUST (Dix) |
Amount | £154,888 (GBP) |
Funding ID | pc3403 |
Organisation | Imperial College London |
Department | Imperial College Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | |
End | 12/2015 |
Description | PS2122 - Neural correlates of vestibular activity (BRC) |
Amount | £12,000 (GBP) |
Funding ID | ps2122 |
Organisation | Hungarian Academy of Sciences (MTA) |
Department | Biological Research Centre (BRC) |
Sector | Academic/University |
Country | Hungary |
Start | 04/2013 |
End | 04/2015 |
Description | Vitual reality video grant |
Amount | £12,000 (GBP) |
Funding ID | WMCT_P61181 |
Organisation | Ménière’s Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2016 |
End | 01/2018 |
Title | Binocular rivalry mediated brain activation |
Description | We found that combining binocular rivalry with vestibular or electrical activation of the brain creates inter-hemisphere competition. |
Type Of Material | Model of mechanisms or symptoms - human |
Provided To Others? | No |
Impact | some publications. |
Title | New brain model underpinning numerical allocation |
Description | A novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextual manner based upon relative magnitude, with the right hemisphere responsible for smaller magnitudes and the left hemisphere for larger magnitudes. Also described in the paper is a heat map method for documenting visual spatial attentional shifts. PMID: 26879093 |
Type Of Material | Model of mechanisms or symptoms - human |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | None so far |
URL | https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhv344 |
Description | Cortical processing of rotational stimuli (Perugia) |
Organisation | University of Perugia |
Country | Italy |
Sector | Academic/University |
PI Contribution | Provided clinical ideas. Data analysis and manuscript writing. |
Collaborator Contribution | Large scale testing of patients. Provided us with a new valuble vestibular stimlus (asymetric rotation) |
Impact | see papers together with V.E. Pettorossi |
Start Year | 2011 |
Description | Human spatial orientation (Marseille) |
Organisation | Aix-Marseille University |
Country | France |
Sector | Academic/University |
PI Contribution | Provided research concepts and infrastructure |
Collaborator Contribution | Research fellows |
Impact | PMID:14663543 PMID:17101157 PMID:23206549 |
Description | Interhemispheric conflicts in spatial processing (Oxford) |
Organisation | University of Oxford |
Department | Department of Experimental Psychology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provided new research topics. |
Collaborator Contribution | Expertise in experimantal psychology. |
Impact | Publications. |
Start Year | 2013 |
Description | Long term vestibular compensation (Zurich) |
Organisation | University of Zurich |
Department | Neurology Department Zurich |
Country | Switzerland |
Sector | Academic/University |
PI Contribution | We've provided the research concept |
Collaborator Contribution | The Swiss team allowed access to their patient database and adapted our research tools to their environment |
Impact | 18604466 |
Start Year | 2007 |
Description | Mutisegmental gaze-led body movements (Athens) |
Organisation | National and Kapodistrian University of Athens |
Country | Greece |
Sector | Academic/University |
PI Contribution | We've provided teh experimental protocol |
Collaborator Contribution | They provided novel maths-based analysis |
Impact | 18718325 19002676 |
Start Year | 2008 |
Description | Normal and abnormal motion sickness (Westminster) |
Organisation | University of Westminster |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have provided our laboratory and research students to sevral projects in common |
Collaborator Contribution | Prof Golding, from the Univ of Westminster is a top researcher in motion sickness and a proficient statistician. His skills are used in many of our projects. |
Impact | 19522361 18619124 |
Description | Scientific basis of neuro-rehabilitation of balance (KCL) |
Organisation | King's College London |
Department | School of Medicine KCL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We provided the research concept/question and the apparatus required |
Collaborator Contribution | 17538212 |
Impact | 17538212 |
Description | Small vessel white matter disease as a cause of balance disorders (Pisa) |
Organisation | University of Pisa |
Country | Italy |
Sector | Academic/University |
PI Contribution | Provided the research question and clinical material. |
Collaborator Contribution | Provided a research fellow. |
Impact | None so far |
Start Year | 2014 |
Description | Visual control of posture (CNRS) |
Organisation | National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) |
Department | Laboratory of Psychology and Neurocognition, University of Savoy |
Country | France |
Sector | Academic/University |
PI Contribution | We've provided the lab and technology |
Collaborator Contribution | They contributed the research question and manpower |
Impact | 18672020 19026959 |
Start Year | 2007 |
Description | Visual cortical excitability and visual dependence (Amsterdam/Antwerp) |
Organisation | Free University of Amsterdam |
Department | Faculty of Human Movement Sciences |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Provided the research question (as described in the MRC grant application) and the laboratory facility. |
Collaborator Contribution | Provided two researchers to execute this project. |
Impact | None so far |
Start Year | 2014 |
Description | Visual cortical excitability and visual dependence (Amsterdam/Antwerp) |
Organisation | University of Antwerp |
Country | Belgium |
Sector | Academic/University |
PI Contribution | Provided the research question (as described in the MRC grant application) and the laboratory facility. |
Collaborator Contribution | Provided two researchers to execute this project. |
Impact | None so far |
Start Year | 2014 |
Title | DVD home-based treatment of 'visual vertigo' and difficult dizziness |
Description | A collection of visual motion images designed for patients to treat their dizziness, either at home or with a physiotherapist |
IP Reference | |
Protection | Copyrighted (e.g. software) |
Year Protection Granted | 2013 |
Licensed | Yes |
Impact | Most physiotherapist want to employ this treatment (www.bsno.org.uk) |
Title | Meniere's disease trial |
Description | This is a clinical trial (RCT) of two drugs (gentamycin vs. dexametasone) delivered trans-tympanically for treatment of refractory meniere's disease. The results have changed the management of advanced Meniere's disease. |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2016 |
Development Status | Closed |
Clinical Trial? | Yes |
Impact | http://www.dailymail.co.uk/health/article-4003528/Can-steroid-jab-ear-banish-dizzy-spells-good-New-treatment-reduces-symptoms-without-risk-severe-hearing-loss.html http://newatlas.com/menieres-disease-steroid-injections/46500/ http://www.sciencenewsline.com/news/2016111712090019.html http://www.enttoday.org/article/intratympanic-corticosteroid-treatment-effective-gentamicin-menieres/ NEW YORK (Reuters Health): http://www.managedhealthcareconnect.com/content/intratympanic-steroids-effective-treating-unilateral-m-ni-res-disease |
URL | http://clinicaltrials.gov/show/NCT00802529 |
Title | Transcranial DC brain stimulation for gait disorders |
Description | We applied tDCS as a proof of principle for the treatment of gait disorders due to leucoaraiosis and Parkinson's disease |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2013 |
Development Status | Actively seeking support |
Impact | N/A |
Description | Articles in national newspapers |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Approximately once a year the media visit our labs for one reason or another, or contact us re. publications that may catch the public's imagination (eg the 'broken escalator effect; clinical trials). This has included Daily Mail, Metro, a local West London Newspaper, Evening Standard, The Times (16/11/2004) and others. These caused increased patient referrals to our clinical services and follow up letters in the newspapers. |
Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2013 |
Description | BBC Radio 4 - Live Interview - Dancers |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Ballet dancers' brains adapt to stop them feeling dizzy. Discussing the research on dancers in PMID: 24072889 Items on the BBC news, ITV news and in national and international newspapers and news websites internationally. |
Year(s) Of Engagement Activity | 2013 |
URL | http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_26-9-2013-17-43-4 |
Description | BBC TV - Bang Goes the Theory - Series 6 Episode 7 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Bang Goes the Theory", Series 6, episode 7 - Motion sickness. Treatment of sickness by regulation of breathing. None so far |
Year(s) Of Engagement Activity | 2012 |
Description | Daily Mail and Daily Mail online |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Treatment of Meniere's disease by intratympanic injection for joint centre randomised, double-blind, clinical trial on unilateral refractory Meniere's disease at Charing Cross Hospital and Leicester Royal Infirmary. Advertised new treatments for Meniere's disease trialled at Charing Cross Hospital between the Neuro-Otology department and Ear Nose and Throat. |
Year(s) Of Engagement Activity | 2012 |
URL | http://www.dailymail.co.uk/health/article-2224996/Dizzy-spells-The-jab-INSIDE-ear-stop-head-spinning... |
Description | Electrical treatment of motion sickness. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Numerous requests for interviews with the team from the media. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.bbc.co.uk/news/health-34145713 |
Description | Imperial Festival Stall "How does what you see affect your balance?" |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | We had over approximately 100 participants a day. Test how their balance can be affected by visual motion, differently in both young and old. We recruited participants for our studies and we were approached by a number of people with pre-existing balance problems who wanted to know more about the topic. |
Year(s) Of Engagement Activity | 2013 |
Description | Imperial Fringe: The Arts Experiment. "Juggling and Neuroscience". |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Explained to an audience how your behavior can influence your brain structure. ??? |
Year(s) Of Engagement Activity | 2013 |
URL | https://www.imperialcollegeunion.org/whats-on/event/391 |
Description | Interviewed for documentary |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview for documentary "Inside the brain of the ultimate athlete" by French-German TV channel ARTE. |
Year(s) Of Engagement Activity | 2016 |
Description | Podcast Interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Podcast Interview on research paper on motion sickness. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.aan.com/rss/search/home/episodedetail/?item=3054 |
Description | Podcast interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Podcast Interview for Imperial College London on Visual Vertigo |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.imperial.ac.uk/department-of-medicine/research/brain-sciences/clinical-translation/neuro... |
Description | Podcast interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Podcast interview hosted by Vivid drinks on expertise and brain function. |
Year(s) Of Engagement Activity | 2016 |
Description | Response to motion sickness paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Many interviews from around the world and referenced on multiple international news websites and media outlets. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.neurology.org/content/85/14/1257.full |
Description | Scientific consultant for play |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Scientific Consultyant for a play called "Testosterone" |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.rhumandclay.com/testosterone |
Description | Wonder Street Fair at the Barbican, part of British Neuroscience Association 2013 Meeting. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | We had over 300 participants over 3 days. Test how their balance can be affected by visual motion, differently in both young and old. We recruited participants for our studies and we were approached by a number of people with pre-existing balance problems who wanted to know more about the topic. |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.bna.org.uk/BNA2013-festival-of-neuroscience.html |