Identifying the prevalence of antibodies to neuronal membrane targets in first episode psychosis
Lead Research Organisation:
University of Oxford
Department Name: Psychiatry
Abstract
In the last ten years there have been breakthroughs in the discovery of new treatment responsive causes of limbic encephalitis. This is a rare, life threatening brain disorder. These new causes have been antibodies against targets on the surface of brain cells. In the descriptions of these new disorders patients often present with promninent psychiatric symptoms, with symptoms of psychosis such as hallucinations and delusions and disordered thinking and impaired memory. However they also develop difficulties with fits, loss of unconsciousness, blood pressure control or electrolyte disturbance which means that they end up under the management of neurologists or intensive care specialists rather than psychiatrists. We were interested whether a proportion of patients with purely psychiatric symptoms of the disorder would also have these antibodies. We therefore tested 47 patients with a first episode of psychosis, without other features of limbic encephalitis and found that 3 of them did have these antibodies. We have since identified, without systematic screening a further 9 patients, and have treated 4 of these by treating their immune system rather than traditional psychiatric medication. This gives further support to the theory that the antibodies are causing the psychosis in these patients. We now wish to establish just how common this disorder is. We want to screen a larger number of patients for all known antibodies that can cause limbic encephalitis. This will help us to estimate how significant a disorder this is, and help with planning clinical services.
Technical Summary
anti-NMDAR and anti-VGKC complex antibodies have been identified as treatment responsive causes of limbic encephalitis. In both disorders psychotic symptoms are the predominant presenting symptoms. There are strong theoretical reasons to associate both of these antibodies with psychotic illness. We have identifed cases of primary psychotic illness, without the other features typical of disorders, with both of these antibodies. We have identified some cases prospectively and have successfully treated 4 cases solely with immunotherapy. These preliminary findings suggest that these antibodies are pathogenic in some cases of first episode psychosis. We therefore wish to establish the prevalence of these antibodies in a cohort of patients at first presentation psychosis. This is a pilot study to establish the prevalence of the disorder. If the number of cases warrants further investigation we would then wish to undertake a larger project to fully characterise the phenotype of this disorder and guide treatment planning in first episode psychosis
Planned Impact
Health:
In other cases of limbic encephalitis caused by these antibodies patients respond to immunotherapy, especially if treatment is started early and aggressively (Irani et al 2010). A significant proportion of cases are paraneoplastic, most commonly associated with ovarian/testicular teratoma. In these cases early removal of the teratoma is also associated with an excellent outcome. In the cases of primary psychosis with antibodies that we have treated with immunotherapy in each case the patient was an inpatient on a psychiatric ward when identified, responded to steroids and/or plasma exchange and was able to be discharged from hospital afterwards. There is therefore the potential for significant benefit for the individual patients, with an identifiable, treatable cause for their psychotic illness.
Wealth:
Psychotic illnesses accounts for a huge cost to the economy, both through direct and indirect costs. Psychosis accounts for more than 50% of all psychiatric inpatient beds. The peak age of onset is in adolescence and at the moment is considered a lifelong disorder. Current treatments are helpful for some symptoms of the disorder, but do not change the illness course. If an aetiology can be identified in even a small proportion of patients there will be significant gains to the economy.
Psychiatric services
The researchers in the application work in academic health science centres with considerable infrastructure to support the rapid translation of new evidence into practice (NIHR BRCs and CLAHRC). The service implications of this research may be the reconfiguration of mental health services to allow access to appropriate investigations and treatments for this new disorder.
Commercial
If novel antigens of relevance to psychosis are discovered, Euroimmun AG would be in a position to develop multiple antigen testing kits specifically for psychiatric disorders, in collaboration with the applicants.
In other cases of limbic encephalitis caused by these antibodies patients respond to immunotherapy, especially if treatment is started early and aggressively (Irani et al 2010). A significant proportion of cases are paraneoplastic, most commonly associated with ovarian/testicular teratoma. In these cases early removal of the teratoma is also associated with an excellent outcome. In the cases of primary psychosis with antibodies that we have treated with immunotherapy in each case the patient was an inpatient on a psychiatric ward when identified, responded to steroids and/or plasma exchange and was able to be discharged from hospital afterwards. There is therefore the potential for significant benefit for the individual patients, with an identifiable, treatable cause for their psychotic illness.
Wealth:
Psychotic illnesses accounts for a huge cost to the economy, both through direct and indirect costs. Psychosis accounts for more than 50% of all psychiatric inpatient beds. The peak age of onset is in adolescence and at the moment is considered a lifelong disorder. Current treatments are helpful for some symptoms of the disorder, but do not change the illness course. If an aetiology can be identified in even a small proportion of patients there will be significant gains to the economy.
Psychiatric services
The researchers in the application work in academic health science centres with considerable infrastructure to support the rapid translation of new evidence into practice (NIHR BRCs and CLAHRC). The service implications of this research may be the reconfiguration of mental health services to allow access to appropriate investigations and treatments for this new disorder.
Commercial
If novel antigens of relevance to psychosis are discovered, Euroimmun AG would be in a position to develop multiple antigen testing kits specifically for psychiatric disorders, in collaboration with the applicants.
Publications
Al-Diwani A
(2017)
Synaptic and Neuronal Autoantibody-Associated Psychiatric Syndromes: Controversies and Hypotheses.
in Frontiers in psychiatry
Al-Diwani A
(2019)
The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.
in The lancet. Psychiatry
Al-Diwani AA
(2018)
Neuroimmunology 2017: making progress over 20 years.
in The lancet. Psychiatry
Al-Diwani AAJ
(2017)
Psychosis: an autoimmune disease?
in Immunology
Behrman S
(2019)
Autoimmune encephalitis in the elderly: who to test and what to test for.
in Evidence-based mental health
Bradley J
(2018)
Treating Sleep Problems in Young People at Ultra-High Risk of Psychosis: A Feasibility Case Series.
in Behavioural and cognitive psychotherapy
Cullen AE
(2021)
Influence of methodological and patient factors on serum NMDAR IgG antibody detection in psychotic disorders: a meta-analysis of cross-sectional and case-control studies.
in The lancet. Psychiatry
Deakin J
(2014)
Antibodies to the N-methyl-D-aspartate receptor and other synaptic proteins in psychosis.
in Biological psychiatry
Endres D
(2022)
Autoantibody-associated psychiatric syndromes: a systematic literature review resulting in 145 cases.
in Psychological medicine
Khandaker GM
(2015)
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment.
in The lancet. Psychiatry
Lennox B
(2022)
The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis.
in Molecular psychiatry
Lennox B
(2023)
Improving our Understanding of Early Psychosis: Learning from the Optimise Trial.
in Schizophrenia bulletin
Lennox B
(2019)
An international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin: the concept of autoimmune psychosis
in The Lancet Psychiatry
Lennox B
(2016)
Neuropsychiatry Case Studies
Lennox B
(2018)
38. DO NMDAR ANTIBODIES CAUSE SCHIZOPHRENIA?
in Schizophrenia Bulletin
Lennox BR
(2012)
Antibody-mediated encephalitis: a treatable cause of schizophrenia.
in The British journal of psychiatry : the journal of mental science
Lennox BR
(2019)
Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1).
in Journal of neurology, neurosurgery, and psychiatry
Lennox, BR
(2017)
Oxford Textbook Inpatient Psychiatry 2017
Makuch M
(2018)
N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications.
in Annals of neurology
Minichino A
(2021)
The gut-microbiome as a target for the treatment of schizophrenia: A systematic review and meta-analysis of randomised controlled trials of add-on strategies.
in Schizophrenia research
Minichino A
(2023)
Psycho-pharmacomicrobiomics: A Systematic Review and Meta-analysis
in Biological Psychiatry
Pollak TA
(2012)
Antibody-mediated encephalitis and psychosis.
in The British journal of psychiatry : the journal of mental science
Pollak TA
(2018)
Time for a change of practice: the real-world value of testing for neuronal autoantibodies in acute first-episode psychosis.
in BJPsych open
Pollak TA
(2020)
Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin.
in The lancet. Psychiatry
Prüss H
(2016)
Emerging psychiatric syndromes associated with antivoltage-gated potassium channel complex antibodies.
in Journal of neurology, neurosurgery, and psychiatry
Puntis S
(2019)
Specialised early intervention teams for first episode psychosis
in Cochrane Database of Systematic Reviews
Puntis S
(2023)
What happens after early intervention? Mapping early intervention in psychosis care pathways in the 12 months after discharge
in Early Intervention in Psychiatry
Rickards H
(2018)
Autoimmune encephalitis: a potentially treatable cause of mental disorder
in Advances in Psychiatric Treatment
Sarkis RA
(2019)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations: A Report of the American Neuropsychiatric Association Committee on Research.
in The Journal of neuropsychiatry and clinical neurosciences
Tang C
(2019)
N-Methyl-D-Aspartate(NMDA) Receptor and Voltage-Gated Potassium Channel (VGKC) Antibody-Associated Encephalitides Presenting as First Episode Acute Psychosis
in Frontiers in Psychiatry
Vann Jones S
(2017)
Elevated homocysteine and N-methyl-d-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome.
in Oxford medical case reports
Whiting D
(2023)
Assessing violence risk in first-episode psychosis: external validation, updating and net benefit of a prediction tool (OxMIV).
in BMJ mental health
Whiting D
(2024)
Approaches and challenges to assessing risk of violence in first episode psychosis: A qualitative interview study of clinicians, patients and carers.
in Early intervention in psychiatry
Williams R
(2023)
Predictors of positive outcomes from 'Early Intervention in Psychosis': protocol for a national retrospective cohort study.
in Frontiers in psychiatry
Williams R
(2023)
Predictors of positive patient-reported outcomes from 'Early Intervention in Psychosis': a national cross-sectional study
in BMJ Mental Health
Zandi MS
(2015)
Clinical relevance of serum antibodies to extracellular N-methyl-D-aspartate receptor epitopes.
in Journal of neurology, neurosurgery, and psychiatry
Zandi MS
(2014)
Immunotherapy for patients with acute psychosis and serum N-Methyl D-Aspartate receptor (NMDAR) antibodies: a description of a treated case series.
in Schizophrenia research
Zandi MS
(2016)
N-Methyl-D-Aspartate Receptor Autoantibodies in Psychiatric Illness.
in Biological psychiatry
Description | change to treatment algorithm for psychosis and schizophrenia |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | MRC Confidence in Concept award University of Oxford |
Amount | £100,070 (GBP) |
Organisation | Medical Research Council (MRC) |
Department | MRC Confidence in Concept Scheme |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2014 |
End | 08/2015 |
Description | MRC DPFS |
Amount | £2,711,781 (GBP) |
Funding ID | MR/N019067/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2016 |
End | 07/2020 |
Description | Stanley Medical Research Institute treatment trials |
Amount | $284,176 (USD) |
Organisation | Stanley Medical Research Institute (SMRI) |
Sector | Charity/Non Profit |
Country | Global |
Start | 06/2015 |
End | 07/2016 |
Description | joint neuroimmunology-psychiatry clinic established |
Organisation | Oxford University Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have established a joint clinic which I run with Camilla Buckley, consultant neurologist at OUH for all patients that we have identified with antineuronal cell surface antibodies |
Collaborator Contribution | contribution to the joint clinic |
Impact | Research nurse - Jon Revis, Neurologist Camilla Buckley, myself as psychiatrist. Has led to application for further funding applications to study the patient cohort |
Start Year | 2013 |
Description | Autoantibodies encephalitis |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Royal College of Psychiatrists Faculty of Liaison Psychiatry Annual Residential Conference 'Integrated Psychological Medicine' 11 May 2016 Holiday Inn City Centre, Birmingham - Talk on Autoantibodies encephalitis |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.rcpsych.ac.uk/pdf/CALC_Liaison%20Faculty%202016prog3March.pdf |
Description | BBC Ideas short film |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | participated in a short film for the series BBC Ideas, titled 'Could psychosis be an autoimmune disease?' which covered the background to the SINAPPS2 trial, and the study design. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.bbc.com/ideas/videos/could-psychosis-be-an-autoimmune-disease/p05zdl33 |
Description | BBC Radio 4 broadcast an exploration into this new understanding of psychiatric disorders earlier this year: The Inflamed Mind |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC Radio 4 broadcast an exploration into this new understanding of psychiatric disorders earlier this year: The Inflamed Mind. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/programmes/b07pj2pw |
Description | Clinical Phenotype of Patients With NMDAR Antibodies |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Clinical Phenotype of Patients With NMDAR Antibodies - a presentation at the 5th Schizophrenia International Research Society Conference on 4th April 2016 |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.schizophreniaconference.org/wp-content/uploads/2016/04/SIRSProgramBook2016.pdf |
Description | Daily Mail feature article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Published in paper and online edition of Daily Mail Multiple contacts from patients and carers interested in the research |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.dailymail.co.uk/health/article-2316825/Driven-insane-immune-One-womans-terrifying-story-r... |
Description | Department of Psychiatry autumn school |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Ran a workshop at the University of Oxford Department of Psychiatry autumn summer school for 30 medical students and Foundation year doctors on a career in academic psychiatry. 3 medical students are working with me on placements and for extra experience in the clinic and the lab. |
Year(s) Of Engagement Activity | 2013,2014 |
Description | Epilepsy masterclass |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 200 participants at a one day masterclass where I spoke on psychiatric aspects of channelopathies Increased interest and collaboration from researchers and clinicians |
Year(s) Of Engagement Activity | 2014 |
Description | Grand round presentations and clinical research network meetings |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I have presented at grand rounds at: Royal London Hospital, Oxford University Hospitals Trust, Cambridge University Hospitals NHS FT, Berkshire Healthcare NHS FT, MHRN national conference Liverpool 2014 Increase in recruitment to study, increase in clinical referrals |
Year(s) Of Engagement Activity | 2013,2014 |
Description | ISEN Annual Meeting, San Francisco |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 45 minute presentation on The Clinical Science of Anti-NMDA Receptor Encephalitis at the Brain Stimulation Afternoon Symposium at the ISEN International Society for ECT & Neurostimulation |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.isen-ect.org/sites/default/files/ISEN_Annual_Meeting_&_Course_Brochure_2019_FINAL.pdf |
Description | NMDAR Antibody Session, Progress in Mind reports from The 6th Biennial Schizophrenia International Research Society Conference (SIRS) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | NMDAR Antibody Session, Progress in Mind reports from The 6th Biennial Schizophrenia International Research Society Conference (SIRS) |
Year(s) Of Engagement Activity | 2018 |
Description | Oxford Neuroscience symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | presnted my research to the Oxford Neuroscience community and invited visitors Was approached by head of neuroscience at Wellcome Trust to apply for funding |
Year(s) Of Engagement Activity | 2014 |
Description | Participation in BBC Radio 4 Series: A History of Delusions |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Interview as part of a Radio 4 series by Professor Daniel Freeman, a clinical psychologist and has been researching and treating delusions for the past twenty years. A History of Delusions was broadcast weekdays at 13.45 on BBC Radio 4 from Monday 3 December to Friday 14 December 2018 |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.bbc.co.uk/programmes/m0001d95/episodes/player |
Description | Participation in a television programme on BBC Two - Trust Me, I'm a Doctor. A special programme focussing on Mental Health |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | In the relevant section of the TV programme - "Could some mental health conditions be caused by an immune malfunction" I explained that some patients who exhibit classic symptoms of psychosis may not actually have a psychiatric condition, but a rare form of encephalitis and that the biological cause for this condition is now increasingly recognized by psychiatrists and neurosurgeons. Patients have been successfully treated with immunotherapy, which removes the rogue antibodies from the patient's blood. This treatment has led to patients making a dramatic recovery. I also described my current research investigating the prevalence of pathogenic antibodies in psychosis and its subsequent treatment. This was followed by a large number of enquiries from members of the public both nationally and internationally. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.bbc.co.uk/programmes/articles/4dbMnJVnLBM9Qqp8rzKD4s3/could-some-mental-health-conditions... |
Description | Presentation and Cambridge Neuroscience Seminar 2017 - The Inflamed Brain - 21 March |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary "The Autoimmune basis of Psychosis - challenges and controversies |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.neuroscience.cam.ac.uk/events/event.php?permalink=dbbbdfb739#plenary |
Description | Presentation at 24th Annual NAPICU Conference, Glasgow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The theme of the conference this year was "Therapeutic Advancements in Acute, Emergency and Secure Mental Health Settings; Reducing Restrictive Interventions". My presentation in the Session on Novel Treatments in Psychiatry was entitled "Autoimmune Causes of Psychosis: Diagnosis and Management |
Year(s) Of Engagement Activity | 2019 |
URL | https://napicu.org.uk/24th-annual-conference-2019-glasgow/ |
Description | Presentation at Mental Health & Neuroimmunology conference, University of Kent |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This conference was for psychiatrists, neuropsychiatrists, neurologists, GPs, neuropsychologists, mental health and frontline medical staff and will focus on neuroimmunology and links to psychosis, blurring the distinction between mental illness and neurological disorders: the association between autoimmune disease and psychosis |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.kmpt.nhs.uk/media/2229/kmpt-neuroimmunology_-external-version-and-booking.pdf |
Description | Presentation at Oxford Autoimmune Neurology Meeting 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a two-day international meeting on 5-6 June 2019 for clinicians and scientists looking to appreciate the breadth of translational autoimmune neurology. This inaugural meeting covered the clinical features of CNS and PNS diseases, methodological aspects of immunological assays, applied T and B cell pathophysiology, and questions relating to immunological tolerance. By being both contemporary and highly translational, the program appealed to consultant and trainee neurologists plus PhD or postdoctoral level researchers who have an interest in the field of autoimmune neurology. |
Year(s) Of Engagement Activity | 2019 |
URL | https://aealliance.org/oxford-autoimmune-neurology-meeting-2019/ |
Description | Presentation at RCP Advanced Medicine Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation entitled "Autoimmune encephalopathies - latest advances" at Royal College of Physcians Advanced Medicine Conference in Birmingham, 20 June, 2016 |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.rcplondon.ac.uk/events/advanced-medicine-manchester |
Description | Presentation at the 6th European Conference on Schizophrenia Research (ECSR) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Symposium presentation entitled: "The diagnosis and management of autoimmune encephalitis in psychiatric settings" at the 6th European Conference on Schizophrenia Research (ECSR), 24/11/2016 |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.cpo-media.net/DGPPN/2016/Programm/HTML/files/assets/common/downloads/publication.pdf |
Description | Presentation: 6th Annual International Psychiatric Pharmacy Conference of CMHP |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Autoimmune mechanisms of schizophrenia |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.cmhp.org.uk/wp-content/uploads/2015/03/CMHP-Conference-programme-2015-Final-Version.pdf |
Description | Presentation: The prevalence of antibodies to neuronal membrane targets in first episode psychosis, RCPsych International Congress 2015, Birmingham |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary: Psychosis and mood disorders S43 Immune Pathogenesis of Psychosis The prevalence of antibodies to neuronal membrane targets in first episode psychosis |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.rcpsych.ac.uk/traininpsychiatry/conferencestraining/internationalcongress2015/programme/t... |
Description | Presentation: The psychiatric management of autoimmune encephalitis at RCPsych International Congress 2015, Birmingham |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary: Organic and Neuropsychiatry TC2 Disorders at the interface of neurology and psychiatry - Part 2 New disorders The psychiatric management of autoimmune encephalitis |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.rcpsych.ac.uk/traininpsychiatry/conferencestraining/internationalcongress2015/programme/t... |
Description | Radio interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | Yes |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC podcast on Naked Scientist website. Linked on University of Oxford website. Contact from several patients asking questions about the research |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.thenakedscientists.com/HTML/content/interviews/interview/1000334/ |
Description | Royal College of Psychiatrists conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 300 attended talk at Royal college Psychiatrists conference. I presented clinical implications of my research which sparked a lot of interest and discussion about change in practice required, and contact made with clinicians from across UK as well as France and Ireland A further 2 sites were added to the PPiP research study |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.rcpsych.ac.uk/traininpsychiatry/conferencestraining/facultysectionconferences/generaladul... |
Description | Schizophrenia International Research Society presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 300 psychiatry researchers from across the world attended a symposium on autoimmune psychosis at the international sociaty meeting collaborations made with other researchers in the field |
Year(s) Of Engagement Activity | 2014 |
Description | Science Interview for The Naked Scientists (www.thenakedscientists.com), University of Cambridge, 24 March 2015 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Recorded interview/discussion entitled "Immune attack on the brain". |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.thenakedscientists.com/HTML/interviews/interview/1001216/ |
Description | Speaker and symposia chair at 14th International Society of Neuroimmunology Congress, Brisbane, Australia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary session on neuroimmunology of schizophrenia and depression. Joint chair of symposium on Neuroimmune Psychiatry - "Autoimmune psychosis - fact or fiction"? |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.isniweb.org/wp-content/uploads/2019/01/PROGRAM.pdf |
Description | Speaker at Royal College of Psychiatrists Faculty of Child and Adolescent Psychiatry Annual Scientific Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Symposium 2: Inflammation and mental illness |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.rcpsych.ac.uk/docs/default-source/events/programmes/rcpsych-cap2019-programme-v4.pdf?sfv... |
Description | Speaker at The Lancet Summit: Inflammation and Immunity in Disorders of the Brain and Mind, Barcelona, Spain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation: Neuropsychiatric manifestations of neuronal autoantibodies Poster: Being autoimmune in psychiatric places: 10 characteristic mental state features in patients with definite NMDAR antibody encephalitis determined by detailed phenotyping |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.thelancetsummit.com/conference-programme.asp |
Description | Speaker at UCL Divisional Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation |
Year(s) Of Engagement Activity | 2019 |
Description | Talk at The 7th Oxford Neurology Course |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Presentation entitled: "The neuropsychiatric manifestations of NMDAR antibodies" a the 7th Oxford Neurology Course, St Anne's College, Oxford 29th June 2016 |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.ndcn.ox.ac.uk/events/7th-oxford-neurology-course-programme.pdf |
Description | Talk to St John's College Medical Society, Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | A talk to the St John's Medical Society on the subject of Antibodies and Psychiatry. |
Year(s) Of Engagement Activity | 2015 |
Description | medical student teaching |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I run a new science session for medical students as part of their psychiatry rotation where I share the story of the research and stimulate their thinking around the neurobiological basis of psychiatric illness and the challenges of finding a brain abnormality that requires a different approach to treatment Interest in placements and special study modules working with me |
Year(s) Of Engagement Activity | 2013,2014 |
Description | multiple media appearances TV and radio, to coincide with publication of paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | multiple media appearances on 8th December 2016, including: The Today programme Radio 4 at 06:33, 07:22, Victoria Derbyshire show BBC2 09.30, BBC World service hourly television, and radio news, One O'Clock news, Six O'Clock news. Also in print in: Daily Mail, The Telegraph, The Metro, Mail on Sunday |
Year(s) Of Engagement Activity | 2016 |