Centre for Reproductive Biomedicine Fellowship Award 2
Lead Research Organisation:
University of Edinburgh
Department Name: MRC Centre for Reproductive Health
Abstract
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Technical Summary
Reproduction is a fundamental feature of all life, essential for the continuation of our species. The remarkable integrative biology of human reproductive tissues is responsible for their outstanding resilience, characterised by long-term maintenance of stem cell populations and repeated episodes of regeneration and scarless healing. In Edinburgh there is now an exciting opportunity to understand the fundamental mechanisms responsible for the resilience and repair of reproductive tissues by bringing together, under new leadership and in a new Centre, outstanding strengths in reproductive health and tissue biology, the stem cell niche, resolution and repair of inflammation, developmental programming by steroids, epigenetics, systems and computational biology and tissue and organ imaging. The added value delivered will enable investigators and trainees in the proposed MRC/University of Edinburgh Centre for Reproductive Health (CRH) to address three linked questions of crucial importance in reproductive health and beyond:
[1] What mechanisms deliver the optimal tissue niches for repeated regeneration of reproductive tissues?
[2] How do reproductive tissues normally achieve scarless healing and what goes wrong when this fails?
[3] How is reproductive resilience programmed by developmental effects of steroids?
The proposed research strategy will offer unparalleled opportunities to understand fundamental processes with implications for resilience and repair in many organs. We will exploit this knowledge to develop novel treatments for the major unmet clinical challenges in reproductive health, to exploit this for impacts across medicine and to provide a rich environment for interdisciplinary research training.
[1] What mechanisms deliver the optimal tissue niches for repeated regeneration of reproductive tissues?
[2] How do reproductive tissues normally achieve scarless healing and what goes wrong when this fails?
[3] How is reproductive resilience programmed by developmental effects of steroids?
The proposed research strategy will offer unparalleled opportunities to understand fundamental processes with implications for resilience and repair in many organs. We will exploit this knowledge to develop novel treatments for the major unmet clinical challenges in reproductive health, to exploit this for impacts across medicine and to provide a rich environment for interdisciplinary research training.
People |
ORCID iD |
Philippa Saunders (Principal Investigator / Fellow) |
Publications
Grieve K
(2015)
The controversial existence and functional potential of oogonial stem cells
in Maturitas
Dunlop CE
(2013)
Ovarian stem cells--potential roles in infertility treatment and fertility preservation.
in Maturitas
Dunlop CE
(2014)
Ovarian germline stem cells.
in Stem cell research & therapy
Dunlop CE
(2016)
Re-implantation of cryopreserved ovarian cortex resulting in restoration of ovarian function, natural conception and successful pregnancy after haematopoietic stem cell transplantation for Wilms tumour.
in Journal of assisted reproduction and genetics
Dunlop CE
(2014)
The regulation and assessment of follicular growth.
in Scandinavian journal of clinical and laboratory investigation. Supplementum
Dunlop CE
(2015)
Uses of anti-Müllerian hormone (AMH) measurement before and after cancer treatment in women.
in Maturitas
Anderson RA
(2015)
Prospective study into the value of the automated Elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool.
in Fertility and sterility