Developmental and meiotic potential of oocytes derived from human ovarian germ line stem cells (OSCs) in vitro.
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Biological Sciences
Abstract
For decades, scientists have believed that women were born with all the eggs they would ever have and that no new ones could ever be made. Recently a group of researchers in the USA isolated a primitive "stem" like cell from the ovaries of adult women. These cells were shown to be capable of forming what appeared to be new eggs (oocytes) when they were injected back into ovarian tissue. The implications of this are potentially enormous, but at the moment we know very little about what these cells may or may not be capable of. If we could make new eggs we could eventually help restore fertility in women who have become infertile for a variety of reasons, including chemotherapy, early menopause or just normal ageing. However, these findings have led to controversy and many questions remain as to whether these new eggs can develop normally. This project will determine whether these cells can be isolated from the ovaries of healthy women from a range of ages. Then using a system which we have developed where we can grow eggs outside the body (culture system), we will determine whether these cells can form new eggs and whether they are normal. The ultimate end point of this work would be to determine whether these cells were capable of forming eggs that could be fertilised and form embryos.
Technical Summary
Cells with germ line potential have been isolated and purified from adult mouse ovary and from human ovarian tissue obtained from adult women. These cells, termed oogonial stem cells (OSCs) have been characterised in mice and after in vivo transplantation they form functional oocytes that can be matured, fertilised and form embryos. The equivalent human cells that have been isolated have been much less fully characterised. Yet the ability to develop these cells into mature oocytes would have many potential applications in assisted reproduction and fertility preservation as well being of huge value as a model for the study of human oogenesis. This project aims to confirm the isolation of this cell population from ovaries of adult women of varying ages and to determine the developmental potential of oocytes derived from human OSCs. To test the developmental potential of human OSCs we will combine them with a multistep culture system recently developed in our lab that supports development of human oocytes from the most immature stage (primordial) to fully developed stages with some being capable of undergoing meiotic maturation to Metaphase II. Using this system our preliminary data show that OSCs form follicles when injected into human ovary tissue, with confirmation that they can undergo the initial stages of folliculogenesis. By combining these two technologies we will be able to explore robustly the full meiotic and developmental potential of these cells, and provide a basis for future studies exploring their therapeutic potential.
Planned Impact
This proposal is to study a newly identified cell type isolated from the ovaries of adult women that appears to have the potential to form new eggs (oocytes). This study will determine whether these newly formed oocytes are normal and viable. The beneficiaries of this proposal will be:
1) Researchers in Reproductive Sciences: Researchers will benefit from this work as it will provide a model to study the early processes of human egg development. It will provide tools to study processes such as meiosis which has previously been in accessible in humans.
2) Students and Scientists will benefit as this project will offer greater insight into a central tenet of mammalian female reproduction. These results could lead to new hypotheses to explain the process of ovarian ageing.
3) Fertility Preservation patients and practitioners would benefit if positive results are obtained. This work could lead to the process of isolating this stem cell population as a method for fertility preservation. This would affect a range of patient groups from cancer sufferers to those with Premature Ovarian Failure and genetic conditions such as Turners syndrome.
4) Assisted Reproductive Technologies; healthcare providers, clinical practitioners and patients. If the results of this project are positive then we will be in a position to develop methodologies for novel approaches to assisted reproduction. These could potentially a) negate the need for hormonal stimulation of the patient, b) avoid multiple surgical procedures to harvest the resultant eggs, c) implement a series of quality control measures to optimise egg selection for subsequent fertilisation and d) improve success rates particularly in older women, and most importantly provide options for women who have no options currently available. All these are highly desirable outcomes for improving the treatment and management of infertile women.
5) Commercial companies. Assisted reproduction is an area of high commercial interest. With any new potential therapies comes the development of a range of techniques to facilitate it. This work would impact on the development of techniques to isolate, store and culture these cells.
1) Researchers in Reproductive Sciences: Researchers will benefit from this work as it will provide a model to study the early processes of human egg development. It will provide tools to study processes such as meiosis which has previously been in accessible in humans.
2) Students and Scientists will benefit as this project will offer greater insight into a central tenet of mammalian female reproduction. These results could lead to new hypotheses to explain the process of ovarian ageing.
3) Fertility Preservation patients and practitioners would benefit if positive results are obtained. This work could lead to the process of isolating this stem cell population as a method for fertility preservation. This would affect a range of patient groups from cancer sufferers to those with Premature Ovarian Failure and genetic conditions such as Turners syndrome.
4) Assisted Reproductive Technologies; healthcare providers, clinical practitioners and patients. If the results of this project are positive then we will be in a position to develop methodologies for novel approaches to assisted reproduction. These could potentially a) negate the need for hormonal stimulation of the patient, b) avoid multiple surgical procedures to harvest the resultant eggs, c) implement a series of quality control measures to optimise egg selection for subsequent fertilisation and d) improve success rates particularly in older women, and most importantly provide options for women who have no options currently available. All these are highly desirable outcomes for improving the treatment and management of infertile women.
5) Commercial companies. Assisted reproduction is an area of high commercial interest. With any new potential therapies comes the development of a range of techniques to facilitate it. This work would impact on the development of techniques to isolate, store and culture these cells.
Publications
Dunlop CE
(2013)
Ovarian stem cells--potential roles in infertility treatment and fertility preservation.
in Maturitas
Dunlop CE
(2014)
Isolation, propagation and characterisation of oogonial stem cells from human and bovine ovarian cortex
in Society for Reproduction and Fertility
Grieve KM
(2014)
Aggregation of bovine oogonial stem cells with mouse somatic cells results in follicle formation
in Society for Reproduction and Fertility
Dunlop C
(2014)
Isolation, purification, and culture of oogonial stem cells from adult human and bovine ovarian cortex
in The Lancet
Dunlop CE
(2014)
Ovarian germline stem cells.
in Stem cell research & therapy
Hummitzsch K
(2015)
Stem cells, progenitor cells, and lineage decisions in the ovary.
in Endocrine reviews
Grieve KM
(2015)
The controversial existence and functional potential of oogonial stem cells.
in Maturitas
McLaughlin M
(2015)
An externally validated age-related model of mean follicle density in the cortex of the human ovary.
in Journal of assisted reproduction and genetics
Albertini DF
(2016)
Deconstructing the winding path to the recapitulation of mammalian oogenesis ex vivo.
in Proceedings of the National Academy of Sciences of the United States of America
Anderson RA
(2016)
Replenishing the adult ovarian follicle population: a fresh look at dogma.
in Molecular human reproduction
Description | MRC Project Grant |
Amount | £750,000 (GBP) |
Funding ID | MR/R003246/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2017 |
End | 08/2020 |
Description | Non EU industry,Commerce and Public Funding award |
Amount | £467,433 (GBP) |
Organisation | OvaScience |
Sector | Private |
Country | United States |
Start | 03/2016 |
End | 07/2017 |
Description | Testing The Health and Therapeutic Potential of In Vitro Derived Oocytes for the restoration of Female Fertility and the Treatment of Infertility |
Amount | £1,201,000 (GBP) |
Funding ID | MR/T025654/1 |
Organisation | University of Leeds |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2024 |
Description | Molecular origin of non-disjunction in human meiotic and early mitotic divisions |
Organisation | University of Warwick |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Prof Richard Anderson and I have formed a collaboration with Prof Adele Marston in Cell Biology UOE who is an expert in the process of Meiosis. We are contributing through generating in vitro grown human oocytes that can be tested for meiotic errors. |
Collaborator Contribution | Prof Adele Marston |
Impact | Wellcome TRust Collaborative grant application |
Start Year | 2017 |
Title | METHODS OF IN VITRO OOCYTE DEVELOPMENT |
Description | Methods of preparing ovarian tissue for primordial follicle growth are presented comprising the steps: providing an ovarian tissue sample comprising cortical tissue and stromal tissue; removing damaged tissue from the ovarian tissue sample where present; removing excess stromal tissue from the ovarian tissue sample where present; and then mechanically stretching the ovarian tissue sample along at least one dimension of the ovarian tissue sample, such that the size of the ovarian tissue sample along the at least one dimension is increased by at least 10%. Methods of growing viable oocyte in vitro, and methods of preparing individual ovarian follicles for growth are also presented. |
IP Reference | US 10,655,101 B2 |
Protection | Patent granted |
Year Protection Granted | 2020 |
Licensed | No |
Impact | This patent has formed part of the MRC DPFS award that we hold with Leeds. There are several commercial companies that have shown an interest and we are negotiating with. |
Title | METHODS OF IN VITRO OOCYTE DEVELOPMENT |
Description | Methods of preparing ovarian tissue for primordial follicle growth are presented comprising the steps: providing an ovarian tissue sample comprising cortical tissue and stromal tissue; removing damaged tissue from the ovarian tissue sample where present; removing excess stromal tissue from the ovarian tissue sample where present; and then mechanically stretching the ovarian tissue sample along at least one dimension of the ovarian tissue sample, such that the size of the ovarian tissue sample along the at least one dimension is increased by at least 10%. Methods of growing viable oocyte in vitro, and methods of preparing individual ovarian follicles for growth are also presented. |
IP Reference | WO2016046557 |
Protection | Patent application published |
Year Protection Granted | 2016 |
Licensed | No |
Impact | One impact is that this culture system can test ovarian tissue that has been cryopreserved before any transplantation. |
Description | Clinical Achievements of Reproductive Medicine: Karolinska Institute Postgraduate Course |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Presented two lectures to a postgraduate course at Karolinska Institute in Stockholm organised by Dr Kenny Rodriguez Wallberg. Talks were directly related to MRC awards, one on in vitro growth of human oocytes and the other on germ line stem cells. This resulted in discussion and further invitations to fertility group meeting in Stockholm later in the year. |
Year(s) Of Engagement Activity | 2015 |
Description | Contributer to a Radio Four Programme: Rewinding the menopause |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Professor Telfer, Professor Richard Anderson and Dr Marie McLaughlin participated in making a radio programme for Radio 4 with Dr Aarathi Prasad. Dr Prasad and BBC producers visited Telfer's laboratory and warched the ongoing work and conducted interviews. This led to increased interest in the work and approaches from other BBC programme makers as well as enquiries from members of the public. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/programmes/b0643vfl |
Description | Excemed Workshop for Clinicians and Embryologists (Helsinki) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a pre- ESHRE workshop to explore new research that would form the basis of next generation fertility treatments. Over 150 practitioners attended and the topic of Evelyn Telfer's presentation (germ line stem cells) sparked many questions and discussion afterwards. This has led to other invitations and interest in this area. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.excemed.org/live-events/pre-eshre-advanced-course-embryology-ivf-today-it-possible-furth... |
Description | Guardian Article on ABVD work |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Our work on ABVD was presented at the ESHRE meeting in Helsinki 2016 and won the best oral presentation award. Hannah Devlin, the Science writer for the Guardian wrote an article describing the work. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.theguardian.com/science/2016/oct/07/evidence-suggests-womens-ovaries-can-grow-new-eggs |
Description | Interview on Radio Scotland for International Women's day |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | An interview with me discussing my work and women who have inspired me. This has led to further invitations. |
Year(s) Of Engagement Activity | 2021 |
Description | Invited Lecture at Pre Congress Course at ESHRE 2020 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | International conference. Resulted in other invitations. |
Year(s) Of Engagement Activity | 2020 |
Description | Invited Speaker Korean Society for Fertility Preservation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I was the only international invited speaker at the Korean Society for Fertility Preservation. My talk generated a great deal of discussion and opened up the potential for collaborative research. |
Year(s) Of Engagement Activity | 2015 |
Description | Invited Speaker at Ovarian Club 2016 Paris |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited to speak on female germline stem cells and their potential clinical use. This presentation contributed to the ongoing debate surrounding female germline stem cells. |
Year(s) Of Engagement Activity | 2016 |
URL | http://oc2016.cme-congresses.com/scientific-program.aspx |
Description | Keynote Speaker at OvaScience Symposium Baltimore. ASRM meeting 2015 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk to practitioners and investors on applications of germ line stem cell work. |
Year(s) Of Engagement Activity | 2015 |
Description | Named one of Porter's Magazine's Incredible Women of 2018 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Named as one of Porter's magazine in recognition of work on in vitro growth of human oocytes. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.ed.ac.uk/news/2018/fertility-pioneer-receives-international-award |
Description | Newspaper article (Guardian) on first ovarian tissue transplantation in UK carried out by Ediburgh Team |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Media coverage of first ovarian transplant in U.K. that was carried out by the Edinburgh team. Newspaper article highlighted the collaborative nature of this work between basic science and clinical work. This led to more media interest and interest from the general public on the development of our in vitro system. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.theguardian.com/science/2015/jun/10/woman-gives-birth-after-pioneering-ovarian-tissue-tr... |
Description | Panel discussion for International women's day 2023. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | A panel discussion organised by Girl up Edinburgh and the Biology Society where female scientists at different stages of their career discussed the rewards and challenges of being a woman in Science. |
Year(s) Of Engagement Activity | 2023 |
Description | Participation in BBC programme: The Insiders' guide to the menopause |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Telfer lab participated in making of a programme on the menopause commissioned by BBC. Kirsty Wark and the production team visited the laboratory and filmed Dr Maclaughlin at work and interviewed Professor Telfer. This programme was broadcast in February 2017. This led directly to discussion of our work and enquiries from the public, media and other sources. |
Year(s) Of Engagement Activity | 2016,2017 |
URL | http://www.bbc.co.uk/programmes/b08fmspd |
Description | Plenary Lecture at Society for the Study of Reproduction 54th Annual SSR Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary lecture at President's symposium to the largest Reproductive Society in North America to communicate and present our ongoing research. This was presented online and had an international audience of over 500.Discussion and questions were initiated and led to follow up invitations and offers of collaboration. |
Year(s) Of Engagement Activity | 2021 |
Description | Podcast for Women in Science day 2015 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | I was interviewed by the University of Edinburgh Biology Society students for a special podcast for Women in Science day. The podcast led to interest from undergraduates and postgraduates and also invitations to speak at some of their events. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.biology.ed.ac.uk/polopoly/podcasts/BIOPOD_OCT_2015_ALD.mp3 |
Description | Press coverage including TV, Radio and newspaper interviews on culturing oocytes in vitro |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Press coverage in the following: AGENCE FRANCE PRESSE, TOP SANTE, EURO NEWS, YAHOO ACTUALITIES, QUEST FRANCE, LE MONDE (France), YAHOO SINGAPORE (Singapore), DEUTSCHE WELLE, DPA, SUDDEUTSCHE ZEITUNG ONLINE, DEUTSCHE PRESSE-AGENTUR (Germany), RADIO NEW ZEALAND NEWS, THE PRESS (New Zealand), IRISH INDEPENDENT, IRISH DAILY MAIL, NEWSTALK, THE JOURNAL (Ireland), AFPBB (Japan), FOX NEWS.COM, NF NEWS, US NEWS AND WORLD REPORT, MED PAGE TODAY, FUTURISM, FORT MILL TIMES, QUARTZ, NEWSER, CNN, SMITHSONIAN, SCIENCE DAILY, SCIENCE, FORBES, NATIONAL GEOGRAPHIC, PARENTS.COM, USA TODAY, IFL SCIENCE (USA), DE TELEGRAAF, WEBLOG DOS JORNAL, NOS NIEUS, REFORMTORISCH DAGBLAD (Netherlands), PRESS TRUST OF INDIA, INDO-ASIAN NEWS SERVICE, HINDUSTAN TIMES, DOMAIN B, ASIAN AGE, HI INDIA, DECCAN CHRONICLE, TIMES OF INDIA (India), AGENCIA EFE, LAVOZDIGITAL, FARO DE VIGO, LA OPINION LA CORUNA, EL PAIS (Spain), DAGENS NYHETER (Sweden), IOL (South Africa), BD NEWS 24 (Bangladesh), POSTMEDIA BREAKING NEWS, CBC, THE SCIENTIST, MING PAO CANADA (Canada), PANAMA AMERICA ONLINE (Panama), TELE TRECE CANAL 13, LA TERCERA, EMOL.COM, DIARIO EL DIA (Chile), JORDAN NEWS AGENCY (Jordan), SPECIAL BROADCASTING SERVICE, NEWS.COM.AU (Australia), NANONEWSNET.RU (Russia), LA PRENSA (Argentina), TELESUR (Cuba), THE NEW VISION (Uganda), ACENTO (Dominican Republic), GALILEO, ANSA NEWS AGENCY, LA VERITA (Italy), NZZ INTERNATIONAL (Switzerland), SECONDS (Indonesia), THE HERALD (Ghana), FRONTERA, THE CHRONICLE OF TODAY (Mexico), NEWSWEEK POLSKA (Poland), GLOBO TV (Brazil), RADIO ROMANIA (Romania), MALAY MAIL (Malaysia), IAFRICA.COM, NIGERIAN TRIBUNE (Pan Africa), REAL TIME NEWS, CHINA TIMES, KENG SHUN DAILY NEWS, YAM NEWS, CENTRAL DAILY NEWS, LIBERTY TIMES, TAIWAN NEWS (Taiwan), SING TAO DAILY, AFP, MING BAO, ORIENTAL DAILY NEWS, SING TAO DAILY (Hong Kong), CD NEWS, WORKER CHINA, XINHUA, JIANGSU CHINA, 163.COM, CHINA SCIENCE AND TECHNOLOGY NET, SCIENCE NET, BUSINESS WEEK, SHENZHEN NEWS, CHINESE ACADEMY OF SCIENCES, CCTV, CREADERS.NET (China) Prof Evelyn Telfer (Biological Sciences) leads study that grows human eggs in a laboratory, in a move that could lead to improved fertility treatments |
Year(s) Of Engagement Activity | 2018 |
Description | Professor Telfer interviewed on Good Morning Scotland, Radio Scotland. Dec 6th 2016 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Interview on observation that ABVD leads to greater number of oocytes. This led to a number of women who had been treated with the drug contacting us and relating their experiences which fits with our research. It also led to Sky news and Kirsty Wark getting in touch about other programmes. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/programmes/b083cx8m#play |
Description | Radio 4 Podcast 28ish days later |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Participated on a Radio series that will be released on BBC Sounds on the 21st of March in its entirety as a podcast. - https://www.bbc.co.uk/sounds. This will also be broadcast across Radio 4, and I am featured in Episode 14: Ovulation. https://www.bbc.co.uk/sounds |
Year(s) Of Engagement Activity | 2022 |
Description | Radio Interview on Newstalk Radio Programme New Zealand: Professor Telfer |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Prof Telfer was invited to participate in an interview on New Zealand Radio on December 7th 2016 to discuss findings published in Human Reproduction relating to increased number of oocytes in young women treated with ABVD chemotherapy. This was broadcast in New Zealand and Australia and published online. This directly led to increased interest from Australia and New Zealand in our research and requests for further information. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.newstalkzb.co.nz/on-air/early-edition/audio/professor-evelyn-telfer-cancer-drug-increasin... |
Description | Radio Interview on Today Programme with John Humphries |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Interview on the morning programme Today with John Humphries to discuss our published work on growing human oocytes in vitro |
Year(s) Of Engagement Activity | 2018 |
Description | Radio Interview on Woman's Hour |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | https://twitter.com/bbcwomanshour/status/1484117119067377665?s=11 A radio interview on BBC radio 4 to discuss in vitro growth and the potential for it to be used instead of conventional IVF. |
Year(s) Of Engagement Activity | 2022 |
URL | https://twitter.com/bbcwomanshour/status/1484117119067377665?s=11 |
Description | School Visit Edinburgh |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | This was a Women in STEM event to encourage and inspire young women to pursue a career in science. |
Year(s) Of Engagement Activity | 2022 |
Description | Science on a Summer's evening |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | A talk given to the general public as part of the College Of Science and Engineering Engagement programme. |
Year(s) Of Engagement Activity | 2019 |
Description | Sky News piece on Telfer group's research 6th December 2016 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Professor Telfer interviewed on Sky News and lab team filmed to highlight the finding of new oocytes being formed after treatment with chemotherapy agents. This has resulted in other media requests and interest from companies regarding collaborations. |
Year(s) Of Engagement Activity | 2016 |
URL | http://news.sky.com/story/cancer-drugs-prompt-ovaries-to-produce-eggs-10685811 |
Description | Speaking at Edinburgh International Science Festival April 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | I gave a presentation on the future of fertility to an audience at the Edinburgh Science Festival. This was facilitated by the journalist Penny Taylor and it sparked a lively discussion and debate, |
Year(s) Of Engagement Activity | 2019 |
Description | Talk to GRECOT ( French Study and Research Group about Ovarian and Testicular tissue Cryopreservation) Paris |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited to speak at Fertility Preservation Forum in Paris. mainly Clinicians and Scientists working on storing ovarian and testicular tissue. My presentation will deal with in vitro follicle development. |
Year(s) Of Engagement Activity | 2017 |
Description | Teaching RCOG |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Health professionals |
Results and Impact | Group of obstetricians and other clinicians attended and asked questions. Some have asked to visit our lab. Arranged lab visits |
Year(s) Of Engagement Activity | 2013 |
Description | Webinar on Fertility Preservation: Progress in Education Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This webinar on Fertility preservation attracted almost 500 attendees and received excellent feedback. It has resulted in further invitations. |
Year(s) Of Engagement Activity | 2020 |