Pathways to psychosis: Investigating environmental, cognitive and genetic mechanisms underlying development of psychotic experiences in young adults
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: School of Medicine
Abstract
Schizophrenia is a severe psychiatric disorder that imposes a substantial burden on sufferers and their families, and is one of the leading causes of disability worldwide. Although treatments for schizophrenia exist there is a pressing need for more effective treatments and for interventions to prevent people from developing this disorder.
Schizophrenia is characterised by hallucinations (for example hearing voices) and delusions (for example an irrational belief that people are plotting to kill you). These are called psychotic experiences, and whilst schizophrenia affects about 1% of the population over the course of their lives, psychotic experiences occur much more commonly, affecting about 5% of adolescents and young adults. Although for most people these experiences are short lived and resolve completely, for some they persist, and may develop over time into a psychotic illness such as schizophrenia.
We aim to study the development of psychotic experiences from childhood through early adulthood to understand more about what causes these to develop, and what factors lead to recovery from these, or conversely, to deterioration and progression to a psychotic illness. We are particularly interested in examining the role of: i) social adversity during childhood and adolescence, characterised for example by childhood maltreatment or repeated victimization from bullying, and ii) cannabis use, on increasing the risk of developing psychotic experiences.
Social adversity and cannabis use can cause abnormalities in regulation of dopamine, an important neurotransmitter in the brain. This is of particular interest as there is very good evidence that increased dopamine activity in a specific brain pathway is a key biological abnormality underlying schizophrenia.
However, whilst there is good evidence of dopamine abnormalities underlying schizophrenia, it is not known how having too much dopamine can lead to someone hearing a voice that isn't there, or developing a belief that someone is plotting to kill them. Studies in cognitive neuroscience go some way to explaining this by demonstrating that altered dopamine function can affect how people perceive stimuli in their environment, and the inferences that they make about these events. For example, people with schizophrenia are more likely to interpret unimportant background stimuli as having important personal relevance, reach decisions based on insufficient evidence, and misattribute self-generated thoughts or speech as coming from an external source.
We aim to study whether abnormalities on cognitive tests of perception and inference are associated with psychotic experiences in young adults, and whether experiences of social adversity and cannabis use are also associated with deficits in these cognitive tests. This work can provide a model whereby social adversity or cannabis can lead to psychotic experiences through effects on perception and inference (via altered dopamine function). This work is important because cognitive processes influencing perception and inference are modifiable, and therefore evidence that they play a role in developing psychotic experiences will prioritize these as potential targets for psychological interventions to prevent people from developing schizophrenia.
Furthermore, although genetic effects play a critical role in determining risk of developing schizophrenia it is not known how this risk is expressed during development from childhood through early adulthood. We will examine how genetic risk for schizophrenia affects a broad range of psychopathology as well as intellectual ability and performance on cognitive tests of perception and inference. By combining work on genetic, psychological and social mechanisms we will increase our understanding of the pathways leading to development of psychotic experiences, to help inform interventions for treatment and prevention of schizophrenia.
Schizophrenia is characterised by hallucinations (for example hearing voices) and delusions (for example an irrational belief that people are plotting to kill you). These are called psychotic experiences, and whilst schizophrenia affects about 1% of the population over the course of their lives, psychotic experiences occur much more commonly, affecting about 5% of adolescents and young adults. Although for most people these experiences are short lived and resolve completely, for some they persist, and may develop over time into a psychotic illness such as schizophrenia.
We aim to study the development of psychotic experiences from childhood through early adulthood to understand more about what causes these to develop, and what factors lead to recovery from these, or conversely, to deterioration and progression to a psychotic illness. We are particularly interested in examining the role of: i) social adversity during childhood and adolescence, characterised for example by childhood maltreatment or repeated victimization from bullying, and ii) cannabis use, on increasing the risk of developing psychotic experiences.
Social adversity and cannabis use can cause abnormalities in regulation of dopamine, an important neurotransmitter in the brain. This is of particular interest as there is very good evidence that increased dopamine activity in a specific brain pathway is a key biological abnormality underlying schizophrenia.
However, whilst there is good evidence of dopamine abnormalities underlying schizophrenia, it is not known how having too much dopamine can lead to someone hearing a voice that isn't there, or developing a belief that someone is plotting to kill them. Studies in cognitive neuroscience go some way to explaining this by demonstrating that altered dopamine function can affect how people perceive stimuli in their environment, and the inferences that they make about these events. For example, people with schizophrenia are more likely to interpret unimportant background stimuli as having important personal relevance, reach decisions based on insufficient evidence, and misattribute self-generated thoughts or speech as coming from an external source.
We aim to study whether abnormalities on cognitive tests of perception and inference are associated with psychotic experiences in young adults, and whether experiences of social adversity and cannabis use are also associated with deficits in these cognitive tests. This work can provide a model whereby social adversity or cannabis can lead to psychotic experiences through effects on perception and inference (via altered dopamine function). This work is important because cognitive processes influencing perception and inference are modifiable, and therefore evidence that they play a role in developing psychotic experiences will prioritize these as potential targets for psychological interventions to prevent people from developing schizophrenia.
Furthermore, although genetic effects play a critical role in determining risk of developing schizophrenia it is not known how this risk is expressed during development from childhood through early adulthood. We will examine how genetic risk for schizophrenia affects a broad range of psychopathology as well as intellectual ability and performance on cognitive tests of perception and inference. By combining work on genetic, psychological and social mechanisms we will increase our understanding of the pathways leading to development of psychotic experiences, to help inform interventions for treatment and prevention of schizophrenia.
Technical Summary
This proposal aims to examine the development of psychotic experiences, at-risk mental states and psychotic disorder from childhood through to early adulthood in the general population, and to investigate social-environmental, cognitive and genetic mechanisms underlying this. We will measure psychotic outcomes in participants of the population-based ALSPAC birth cohort when they are age 24-25, a critical period as this is the peak age of incidence for schizophrenia. ALSPAC has a wealth of detailed information already available on the cohort participants including data from semi-structured interviews of psychotic experiences during childhood and adolescence that will allow us to track these experiences during development and study their impact on functioning and transition into psychotic disorder during early adulthood.
We will also examine the effects of social adversity and cannabis use on trajectories of psychotic experiences, and study how deficits in cognitive processes relating to perception and inference relate both to psychotic experiences in early adulthood, and to earlier experiences of social adversity and cannabis use. This work can inform us as to how these environmental exposures lead to development of psychotic phenomena, and help identify targets for interventions. We will also examine how genetic risk for schizophrenia, indexed by a composite measure of common alleles conferring increased risk of this disorder, is manifest phenotypically during development from childhood through early adulthood in a population-based sample, including expression of risk through cognitive processes relating to perception and inference. To address these questions we will use appropriate statistical techniques including structural equation models and mixture modeling techniques to examine changes in repeated measures over time, marginal structural models to deal with time-varying confounding, and multiple imputation to address issues relating to attrition.
We will also examine the effects of social adversity and cannabis use on trajectories of psychotic experiences, and study how deficits in cognitive processes relating to perception and inference relate both to psychotic experiences in early adulthood, and to earlier experiences of social adversity and cannabis use. This work can inform us as to how these environmental exposures lead to development of psychotic phenomena, and help identify targets for interventions. We will also examine how genetic risk for schizophrenia, indexed by a composite measure of common alleles conferring increased risk of this disorder, is manifest phenotypically during development from childhood through early adulthood in a population-based sample, including expression of risk through cognitive processes relating to perception and inference. To address these questions we will use appropriate statistical techniques including structural equation models and mixture modeling techniques to examine changes in repeated measures over time, marginal structural models to deal with time-varying confounding, and multiple imputation to address issues relating to attrition.
Planned Impact
The aim of this research is to understand more about the development of psychotic experiences from childhood through to young adulthood, and about the bio-psycho-social mechanisms underlying this. The personal and economic burden of psychotic disorders is substantial, and there is a pressing need for more effective therapies to treat psychosis, and to prevent transition in high-risk individuals. This research project is focused on questions that will have an impact beyond the academic environment, with other beneficiaries described below.
Service users and families
Understanding more about the cognitive mechanisms that translate biological abnormalities into the experience of hearing voices or development of delusional beliefs is critical to aid the development of effective psychological treatments for psychosis. Identifying relevant cognitive processes to target for such interventions will benefit patients with psychotic experiences by improving outcomes and reducing disability across a broad spectrum of clinical diagnoses. This will also benefit the pharmaceutical industry as it will inform the development of new markers for use as surrogate endpoints in experimental medicine and early phase clinical trials. A better understanding of how psychotic experiences develop will also benefit patients and their families by reducing the stigma associated with psychotic disorders.
Young people in the community
Identifying modifiable dysfunctional cognitive processes involved in the aetiology of psychosis will also inform preventive interventions. The potential for such interventions to be applied at a population (for example school) level rather than targeting high-risk individuals will confer a greater public health impact on reducing psychosis and other adverse outcomes that result from dysfunctional cognitive processes. This is particularly attractive as it means that young people who are not engaged in clinical services will also benefit, whilst applying interventions at a broad level also reduces stigma associated with targeted approaches. In the longer term this will benefit young people by reducing their risk of transition into clinical disorder. Improving cognitive biases will also improve relationships and social and occupational functioning, thus having economic impact as well as improving quality of life. A greater understanding of long-term effects of victimization on development of psychosis will enhance the drive to target and reduce the occurrence of such behaviour in schools and work places. This will confer benefits to all individuals within such organisations and lead to benefits in relation to other (non-psychotic) aspects of mental health and well-being, as well as improving quality of life.
Public sector, policy and practice
Our work previously on the relationship between cannabis use and psychosis has been presented to government advisory boards and contributed to debates about policy. It has also been used to inform the public about the possible mental health consequences of use of this drug. Through engagement with the young people involved in this study, and with the wider public (as detailed in the Pathways to Impact), the work from this project can benefit members of the general public by providing information that can help them make informed decisions about use of cannabis, and about their level of risk if, for example, they have an increased inherited risk of psychosis. This research will increase the quality of information contributing to the debate about the effects of cannabis use amongst policy-makers and the wider public.
Understanding the risk of transition from psychotic experiences to disorder, and factors influencing this will benefit practitioners who are often faced with difficult questions about risk prediction when robust estimates from large population-based samples are not available. Such knowledge can help them advise high-risk individuals appropriately.
Service users and families
Understanding more about the cognitive mechanisms that translate biological abnormalities into the experience of hearing voices or development of delusional beliefs is critical to aid the development of effective psychological treatments for psychosis. Identifying relevant cognitive processes to target for such interventions will benefit patients with psychotic experiences by improving outcomes and reducing disability across a broad spectrum of clinical diagnoses. This will also benefit the pharmaceutical industry as it will inform the development of new markers for use as surrogate endpoints in experimental medicine and early phase clinical trials. A better understanding of how psychotic experiences develop will also benefit patients and their families by reducing the stigma associated with psychotic disorders.
Young people in the community
Identifying modifiable dysfunctional cognitive processes involved in the aetiology of psychosis will also inform preventive interventions. The potential for such interventions to be applied at a population (for example school) level rather than targeting high-risk individuals will confer a greater public health impact on reducing psychosis and other adverse outcomes that result from dysfunctional cognitive processes. This is particularly attractive as it means that young people who are not engaged in clinical services will also benefit, whilst applying interventions at a broad level also reduces stigma associated with targeted approaches. In the longer term this will benefit young people by reducing their risk of transition into clinical disorder. Improving cognitive biases will also improve relationships and social and occupational functioning, thus having economic impact as well as improving quality of life. A greater understanding of long-term effects of victimization on development of psychosis will enhance the drive to target and reduce the occurrence of such behaviour in schools and work places. This will confer benefits to all individuals within such organisations and lead to benefits in relation to other (non-psychotic) aspects of mental health and well-being, as well as improving quality of life.
Public sector, policy and practice
Our work previously on the relationship between cannabis use and psychosis has been presented to government advisory boards and contributed to debates about policy. It has also been used to inform the public about the possible mental health consequences of use of this drug. Through engagement with the young people involved in this study, and with the wider public (as detailed in the Pathways to Impact), the work from this project can benefit members of the general public by providing information that can help them make informed decisions about use of cannabis, and about their level of risk if, for example, they have an increased inherited risk of psychosis. This research will increase the quality of information contributing to the debate about the effects of cannabis use amongst policy-makers and the wider public.
Understanding the risk of transition from psychotic experiences to disorder, and factors influencing this will benefit practitioners who are often faced with difficult questions about risk prediction when robust estimates from large population-based samples are not available. Such knowledge can help them advise high-risk individuals appropriately.
Organisations
- CARDIFF UNIVERSITY (Lead Research Organisation)
- University of Manchester (Collaboration)
- University College London (Collaboration)
- Lancaster University (Collaboration)
- Karolinska Institute (Collaboration)
- University of Warwick (Collaboration)
- Orygen Youth Health (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- Royal College of Surgeons in Ireland (Collaboration)
- University of Adelaide (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- Mount Sinai Hospital (USA) (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Croft J
(2022)
A Computational Analysis of Abnormal Belief Updating Processes and Their Association With Psychotic Experiences and Childhood Trauma in a UK Birth Cohort
in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Sullivan SA
(2020)
A Population-Based Cohort Study Examining the Incidence and Impact of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder.
in The American journal of psychiatry
Agbaje AO
(2024)
Accelerometer-based sedentary time and physical activity from childhood through young adulthood with progressive cardiac changes: a 13-year longitudinal study.
in European journal of preventive cardiology
Riglin L
(2021)
ADHD and depression: investigating a causal explanation.
in Psychological medicine
Hines LA
(2023)
Adverse childhood experiences and adolescent cannabis use trajectories: findings from a longitudinal UK birth cohort.
in The Lancet. Public health
Davies J
(2018)
Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms.
in Social psychiatry and psychiatric epidemiology
Russell AE
(2021)
An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt.
in BMC psychiatry
Description | IMPETUS: Investigating Markers derived from Proteomics for Estimation of Transition from the Ultra high risk State to psychotic disorder |
Amount | £1,122,676 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2020 |
End | 12/2023 |
Description | Investigating genetic and environmental risk for psychosis mediated through L-Type voltage gated calcium channels |
Amount | £764,295 (GBP) |
Funding ID | MR/R011397/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2018 |
End | 10/2022 |
Description | Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: ALSPAC-MRI-II |
Amount | £1,762,268 (GBP) |
Funding ID | MR/S003436/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2019 |
End | 03/2023 |
Description | Pathfinders Grant |
Amount | £1,497,192 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2020 |
Description | Religious belief, health and disease: a family perspective. II. The follow-up and data analysis |
Amount | £7,986,970 (GBP) |
Funding ID | ID61917 |
Organisation | The John Templeton Foundation |
Sector | Academic/University |
Country | United States |
Start | 09/2021 |
End | 09/2026 |
Description | Research Grant |
Amount | € 329,048 (EUR) |
Funding ID | HRA-PHR-2015-1293 |
Organisation | Health Services Executive |
Sector | Public |
Country | Ireland |
Start | 06/2016 |
End | 07/2019 |
Description | The mediating effect of inflammatory markers on the association between genetic risk for psychiatric disorders and psychosis, negative symptoms, depression and anxiety |
Amount | £29,874 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2020 |
End | 07/2022 |
Description | Tracking Trajectories of Psychopathology from Infancy to Young Adulthood: an Irish national longitudinal cohort study |
Amount | € 357,142 (EUR) |
Funding ID | ILP-PHR-2019-009 |
Organisation | Health Research Board (HRB) |
Sector | Public |
Country | Ireland |
Start | 01/2020 |
End | 01/2024 |
Description | Using deep learning approaches to examine serious mental illness and physical multimorbidity across the life-course: from mechanisms towards novel interventions |
Amount | £118,422 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 01/2021 |
End | 09/2021 |
Description | Aetiology of psychosis - Cambridge |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Grant lead, analysis of data, writing papers |
Collaborator Contribution | n/a |
Impact | MRC Research Grants, publications |
Start Year | 2010 |
Description | Aetiology of psychosis - UCL |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Grant lead, analysis of data, writing papers |
Collaborator Contribution | n/a |
Impact | MRC research grants & publications |
Start Year | 2013 |
Description | Biomarkers for psychosis - RCSI |
Organisation | Royal College of Surgeons in Ireland |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Co-app on grant, obtaining data, co-authoring papers |
Collaborator Contribution | Led grant application and co-authored/led papers |
Impact | HBI Research Grants Publications |
Start Year | 2014 |
Description | Bipolar - Glasgow |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Grant lead, co-supervising student |
Collaborator Contribution | n/a |
Impact | MHRUK studentship and publications |
Start Year | 2015 |
Description | Multimorbidity prediction work |
Organisation | Queen Mary University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Co-I on grant application |
Collaborator Contribution | Co-leading grant application (with Golam Khandaker at University of Bristol) |
Impact | Successful grant application |
Start Year | 2020 |
Description | PTSD and psychosis - Lancaster |
Organisation | Lancaster University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Preparation of grant application |
Collaborator Contribution | n/a |
Impact | Grant application |
Start Year | 2015 |
Description | PTSD and psychosis - Liverpool |
Organisation | University of Liverpool |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Preparation of grant application (Bentall) Publications (Gage) |
Collaborator Contribution | Co-authored and led publications Led grant application |
Impact | Publications |
Start Year | 2015 |
Description | PTSD and psychosis - Manchester |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Preparation of grant application |
Collaborator Contribution | Leading grant application |
Impact | Grant application |
Start Year | 2015 |
Description | Psychiatric epidemiology - Adelaide |
Organisation | University of Adelaide |
Country | Australia |
Sector | Academic/University |
PI Contribution | Provided data, co-authorship on publications |
Collaborator Contribution | Authorship of publications |
Impact | None yet |
Start Year | 2018 |
Description | Psychosis epidemiology - KI |
Organisation | Karolinska Institute |
Country | Sweden |
Sector | Academic/University |
PI Contribution | Analysis of data, writing papers, contribution to grant |
Collaborator Contribution | Analysis of data, writing papers, leading grant |
Impact | Grants and publications |
Description | Psychosis epidemiology - Melbourne |
Organisation | Orygen Youth Health |
Country | Australia |
Sector | Hospitals |
PI Contribution | Publications |
Collaborator Contribution | Publications |
Impact | Publications |
Start Year | 2019 |
Description | Psychosis epidemiology - Mt Sinai |
Organisation | Mount Sinai Hospital (USA) |
Country | United States |
Sector | Hospitals |
PI Contribution | Preparation & submission of grant applications |
Collaborator Contribution | Grant funding |
Impact | Publications Research Grant |
Start Year | 2015 |
Description | Psychosis epidemiology - RCSI |
Organisation | Royal College of Surgeons in Ireland |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Grant lead, analysis of data, writing papers |
Collaborator Contribution | n/a |
Impact | MRC & HBRI Research Grants, publications |
Start Year | 2010 |
Description | Psychosis epidemiology - Warwick |
Organisation | University of Warwick |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Grant lead, analysis of data, writing papers |
Collaborator Contribution | n/a |
Impact | MRC Research Grants & publications |
Start Year | 2012 |
Description | Psychosis prediction (KCL) |
Organisation | King's College London |
Department | Institute of Psychiatry, Psychology & Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Agreed to share prediction model to test in KCL-held data |
Collaborator Contribution | Agreed to test prediction model as external validation |
Impact | None as yet |
Start Year | 2020 |
Description | BAP |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on research |
Year(s) Of Engagement Activity | 2015 |
Description | Continuing Medical Education item |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We were invited to provide develop the work from one of our publications arising from this grant as a series of CME questions, primarily aimed at psychiatry trainees This was only done recently so too early to gauge impact |
Year(s) Of Engagement Activity | 2020 |
Description | Interview on study |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | To engage public in research study |
Year(s) Of Engagement Activity | 2015 |
Description | Keynote lecture at the Tokyo Academy of Medical Sciences |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote address about our work on psychotic experiences in the ALSPAC cohort funded by MRC grant. This led to new collaborations and development of joint research projects |
Year(s) Of Engagement Activity | 2019 |
Description | Malta Talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation |
Year(s) Of Engagement Activity | 2017 |
Description | Malta talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on research |
Year(s) Of Engagement Activity | 2015 |
Description | Media interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Interview describing work from this grant to increase dissemination of results to a wider academic / clinical audience Only recently done so too early to gauge impact |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.healio.com/psychiatry/schizophrenia/news/online/%7B2f46fd6b-b811-42d9-83f4-61294b203050%... |
Description | Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Podcast in American Journal of Psychiatry describing one of the publications arising from this grant. Only recently done so impact not known as yet |
Year(s) Of Engagement Activity | 2020 |
Description | Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Podcast of main findings from ALSPAC work on psychotic experiences |
Year(s) Of Engagement Activity | 2020 |
Description | Presentation at BAP |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Research presentation |
Year(s) Of Engagement Activity | 2016 |
Description | Schizophrenia International Research Society Biennial meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Gave a presentation at the SIRS biennial meeting in Florence which resulted in research related questions and debate. |
Year(s) Of Engagement Activity | 2016 |
Description | Talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Talk on research |
Year(s) Of Engagement Activity | 2016 |
Description | Talk KCL |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of funded work on psychosis using ALSPAC data. This talk led to the start of a new collaboration, with plans for potential projects across institutions and applications for funding of these. |
Year(s) Of Engagement Activity | 2021 |
Description | Talk at WCE Conference. Tokyo |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk about work funded by this grant to other researchers, many of who are involved with setting up a similar cohort in Tokyo to the one we used for our work Collaborations since then are contributing to joint pieces of work that will lead to publications and potentially new grant applications |
Year(s) Of Engagement Activity | 2018 |
Description | WCPG talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk to disseminate our research funded by MRC grant. Interest and discussions and new collaboration that has led to a grant application - though hard to know to what extent this could be attributed to this talk per se |
Year(s) Of Engagement Activity | 2018 |
Description | Winter School |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Delivered talk: Psychosocial interventions - a basic introduction |
Year(s) Of Engagement Activity | 2016 |
Description | Winter School in Psychiatry 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Undergraduate students |
Results and Impact | Two day event at Hadyn Ellis aimed at medical undergraduates. |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eventbrite.co.uk/e/winter-school-in-psychiatry-2018-tickets-40548337168 |
Description | Youth Mental Health |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Meeting to devise policy recommendations to present to EU government |
Year(s) Of Engagement Activity | 2014 |
Description | interview on paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | To educate readers about our research |
Year(s) Of Engagement Activity | 2016 |