MRC Centre for Neurodevelopmental Disorders
Lead Research Organisation:
King's College London
Department Name: Developmental Neurobiology
Abstract
Neurodevelopmental disorders are a group of disorders in which the development of the brain is disturbed. This can manifest as neuropsychiatric problems or impaired motor function, learning, language or non-verbal communication. These disorders include epilepsy, intellectual disability, autism, and even other diseases with a relatively late onset, such as schizophrenia. These disorders are very difficult to treat and often cause a life-long disability.
The development of the brain is a highly orchestrated process, controlled by genetic information under very clear influence from the environment. In humans, brain development prolongs from early in life to adolescence, when many connections between neurons, the cells of the brain, are actively remodelled. Any deviation from this very protracted program can result in neurodevelopmental disorders and, depending on specific timing, might lead to distinct pathology later in life.
Neurodevelopmental disorders have a prominent genetic basis, although this does not necessarily mean that they are hereditary. For instance, many patients carry de novo mutations - an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself. Recent advances in human genetics have identified specific mutations with these disorders. Unfortunately, we still do not understand how these mutations and concomitant environmental insults cause neurodevelopmental disorders.
Our vision is to build a world-class Centre at King's College London with research programmes that will transform our understanding of the origin of neurodevelopmental disorders. To this end, we will investigate the biological mechanisms underlying these disorders in human patients and animal models. We will also train and nurture the next generation of scientific leaders in the field, equipped to dissolve the boundaries that exist between basic research and clinical disciplines.
In the long term, we aim to translate the new knowledge into clinical advances that change the lives of affected individuals and their families, in collaboration with industrial partners, other research centres and patient associations.
The development of the brain is a highly orchestrated process, controlled by genetic information under very clear influence from the environment. In humans, brain development prolongs from early in life to adolescence, when many connections between neurons, the cells of the brain, are actively remodelled. Any deviation from this very protracted program can result in neurodevelopmental disorders and, depending on specific timing, might lead to distinct pathology later in life.
Neurodevelopmental disorders have a prominent genetic basis, although this does not necessarily mean that they are hereditary. For instance, many patients carry de novo mutations - an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself. Recent advances in human genetics have identified specific mutations with these disorders. Unfortunately, we still do not understand how these mutations and concomitant environmental insults cause neurodevelopmental disorders.
Our vision is to build a world-class Centre at King's College London with research programmes that will transform our understanding of the origin of neurodevelopmental disorders. To this end, we will investigate the biological mechanisms underlying these disorders in human patients and animal models. We will also train and nurture the next generation of scientific leaders in the field, equipped to dissolve the boundaries that exist between basic research and clinical disciplines.
In the long term, we aim to translate the new knowledge into clinical advances that change the lives of affected individuals and their families, in collaboration with industrial partners, other research centres and patient associations.
Technical Summary
The MRC Centre for Neurodevelopmental Disorders will bring together world-leading researchers in psychiatry, neonatology, neurology and neuroscience with the goal of identifying the biological mechanisms underlying neurodevelopmental disorders. This synergy will lead to breakthroughs in understanding which would otherwise not be possible. To reach this goal, we will combine mechanistic studies on patients and the genetic discoveries that are becoming available through the work of large sequencing consortia to guide our interrogation of specific brain circuits in both animal models and humans. In addition, we will explore how environmental factors influence the impact of disease susceptibility genes, both in humans and in animal models.
Our research will focus on epilepsy, autism spectrum disorder and schizophrenia, three disorders that are largely caused by abnormal brain development. These are high prevalence diseases which cause long-term burden, and are very difficult to treat. In addition, although these conditions represent a spectrum of diseases with broad sets of causes and clinical manifestations, they have overlapping phenotypes and genetics, which are suggestive of common deficits. The research focus of the new Centre is justified by our top clinical expertise in this field, the access to large patient populations, and our existing high-profile research programmes on neurodevelopment.
In five years, we will contribute to dissolving the boundaries that exist across clinical disciplines and that prevent an integrated understanding of common versus distinct biological mechanisms in neurodevelopmental disorders. Our unique combination of basic and clinical researchers will train and nurture the next generation of scientific leaders in the field, equipped with a translational agenda and a multidisciplinary set of skills. Finally, we also expect the Centre to develop new collaborations with Industry to identify and test new treatments for these disorders.
Our research will focus on epilepsy, autism spectrum disorder and schizophrenia, three disorders that are largely caused by abnormal brain development. These are high prevalence diseases which cause long-term burden, and are very difficult to treat. In addition, although these conditions represent a spectrum of diseases with broad sets of causes and clinical manifestations, they have overlapping phenotypes and genetics, which are suggestive of common deficits. The research focus of the new Centre is justified by our top clinical expertise in this field, the access to large patient populations, and our existing high-profile research programmes on neurodevelopment.
In five years, we will contribute to dissolving the boundaries that exist across clinical disciplines and that prevent an integrated understanding of common versus distinct biological mechanisms in neurodevelopmental disorders. Our unique combination of basic and clinical researchers will train and nurture the next generation of scientific leaders in the field, equipped with a translational agenda and a multidisciplinary set of skills. Finally, we also expect the Centre to develop new collaborations with Industry to identify and test new treatments for these disorders.
Planned Impact
Beneficiaries:
The MRC Centre for Developmental Disorders will mainly carry out research on the neurobiological and environmental causes of epilepsy, autism spectrum disorders and schizophrenia. The beneficiaries from our research will be: (1) pharmaceutical companies, (2) policy-makers, and (3) patients and their families. We will valorise the entire dataset for further exploitation by the UK and/or global industry because this is in the best interest of the population of patients with neurodevelopmental disorders. Should the full potential of our scientific strategy come to fruition, the financial saving due to halting disease progression will be considerable.
Expected impacts:
Disease prevention and health promotion: More than 129 billion euros (as of 2010) are spent each year in Europe on the disorders that are the focus of this proposal. Our Centre will work towards the identification of the mechanisms causing these disorders. We will also identify how these mechanisms interact at different 'critical periods' (e.g., at birth) with environmental factors. This will help prevent neurodevelopmental disorders by defining the time at which specific pathophysiology should be targeted. More effective treatments based on the underlying pathophysiology will substantially reduce costs of health care.
Raising awareness and combating stigmatization: Our Centre will commit to raising public awareness on neurodevelopmental disorders. One of our main objectives is to educate professionals and the public about neurodevelopmental disorders to combat stigmatization and to promote a healthy life style. This is particularly important for schizophrenia, which has a long history of neglect, demonisation and concealment.
Therapy development through biologically validated targets: Selection of targets in psychiatry is driven largely by historical success. We propose working with genetic variants associated with neurodevelopmental disorders to identify common abnormal pathways, i.e., points of convergence, which could become new therapeutic targets.
Therapy development through more effective clinical trials: A fundamental problem in neurodevelopmental clinical trials is the reliance on a list of subjective criteria (as in DSM-5), which leads to the selection of a biologically heterogeneous population. We will use biomarkers to identify signatures that predict outcome, thereby providing a rational basis for patient selection and stratification in clinical trials. This should lead to more efficient and cost-effective clinical trials, thereby facilitating the development of new therapies.
Provision of specialists in neurodevelopmental disorders: We will train a new generation of scientists and clinicians with an integrated view of neurodevelopmental disorders. The provision of these specialists to the workforce will improve the competitiveness of the UK in this field, and will contribute to increase the effectiveness of public services.
Improving speed of impact: We will liaise with major stakeholders such as the EMA, patient organizations and Pharma, to help define the shortest development pathway for regulatory and market approval, making our findings available to the patients as quickly as possible.
Improving health services: Our Centre will play a major role in a nationwide effort to coordinate research and clinical practice through an MRC-funded Neurodevelopmental Disorders Network. In particular, we will contribute to redefining these disorders based on empirical evidence as opposed to classical diagnostic boundaries. This concerted effort should contribute to increasing the effectiveness of public services in the UK, and serve as a model for other European countries.
The MRC Centre for Developmental Disorders will mainly carry out research on the neurobiological and environmental causes of epilepsy, autism spectrum disorders and schizophrenia. The beneficiaries from our research will be: (1) pharmaceutical companies, (2) policy-makers, and (3) patients and their families. We will valorise the entire dataset for further exploitation by the UK and/or global industry because this is in the best interest of the population of patients with neurodevelopmental disorders. Should the full potential of our scientific strategy come to fruition, the financial saving due to halting disease progression will be considerable.
Expected impacts:
Disease prevention and health promotion: More than 129 billion euros (as of 2010) are spent each year in Europe on the disorders that are the focus of this proposal. Our Centre will work towards the identification of the mechanisms causing these disorders. We will also identify how these mechanisms interact at different 'critical periods' (e.g., at birth) with environmental factors. This will help prevent neurodevelopmental disorders by defining the time at which specific pathophysiology should be targeted. More effective treatments based on the underlying pathophysiology will substantially reduce costs of health care.
Raising awareness and combating stigmatization: Our Centre will commit to raising public awareness on neurodevelopmental disorders. One of our main objectives is to educate professionals and the public about neurodevelopmental disorders to combat stigmatization and to promote a healthy life style. This is particularly important for schizophrenia, which has a long history of neglect, demonisation and concealment.
Therapy development through biologically validated targets: Selection of targets in psychiatry is driven largely by historical success. We propose working with genetic variants associated with neurodevelopmental disorders to identify common abnormal pathways, i.e., points of convergence, which could become new therapeutic targets.
Therapy development through more effective clinical trials: A fundamental problem in neurodevelopmental clinical trials is the reliance on a list of subjective criteria (as in DSM-5), which leads to the selection of a biologically heterogeneous population. We will use biomarkers to identify signatures that predict outcome, thereby providing a rational basis for patient selection and stratification in clinical trials. This should lead to more efficient and cost-effective clinical trials, thereby facilitating the development of new therapies.
Provision of specialists in neurodevelopmental disorders: We will train a new generation of scientists and clinicians with an integrated view of neurodevelopmental disorders. The provision of these specialists to the workforce will improve the competitiveness of the UK in this field, and will contribute to increase the effectiveness of public services.
Improving speed of impact: We will liaise with major stakeholders such as the EMA, patient organizations and Pharma, to help define the shortest development pathway for regulatory and market approval, making our findings available to the patients as quickly as possible.
Improving health services: Our Centre will play a major role in a nationwide effort to coordinate research and clinical practice through an MRC-funded Neurodevelopmental Disorders Network. In particular, we will contribute to redefining these disorders based on empirical evidence as opposed to classical diagnostic boundaries. This concerted effort should contribute to increasing the effectiveness of public services in the UK, and serve as a model for other European countries.
Organisations
- King's College London (Lead Research Organisation)
- BenevolentAI (Collaboration)
- University of Coimbra (Collaboration)
- University of Basel (Collaboration)
- The Hospital for Sick Children (SickKids) (Collaboration)
- Karolinska Institute (Collaboration)
- University of Groningen (Collaboration)
- Keio University (Collaboration)
- Evelina London Children's Hospital (Collaboration)
- AstraZeneca (Collaboration)
- Cardiff University (Collaboration)
- Technical University of Dresden (Collaboration)
- European College of Neuropsychopharmacology (ECNP) (Collaboration)
- Bill & Melinda Gates Foundation (Collaboration)
- Icahn School of Medicine at Mount Sinai (Collaboration)
- UNIVERSITY OF LEEDS (Collaboration)
- Bit.Bio (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Francis Crick Institute (Collaboration)
- University College London (Collaboration)
- George Washington University (Collaboration)
- University of Ulm (Collaboration)
- Italian Institute of Technology (Istituto Italiano di Tecnologia IIT) (Collaboration)
- M Squared Lasers Ltd (Collaboration)
- Washington University in St. Louis (Collaboration)
- Birkbeck, University of London (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- F. Hoffmann-La Roche AG (Collaboration)
- Yale University (Collaboration, Project Partner)
- Mount Sinai Hospital (Collaboration)
- European Commission (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- University of California, Davis (Project Partner)
- University of California, Los Angeles (Project Partner)
- University of Oxford (Project Partner)
- Newcastle University (Project Partner)
- University of Pittsburgh Medical Center (Project Partner)
Publications
Aabdien A
(2024)
Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.
in The European journal of neuroscience
Abbas F
(2017)
A Three-Layer Network Model of Direction Selective Circuits in the Optic Tectum.
in Frontiers in neural circuits
Abel KM
(2018)
Preliminary evidence for neural responsiveness to infants in mothers with schizophrenia and the implications for healthy parenting.
in Schizophrenia research
Abela E
(2019)
Slower alpha rhythm associates with poorer seizure control in epilepsy.
in Annals of clinical and translational neurology
Adams RA
(2020)
Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models.
in Cerebral cortex (New York, N.Y. : 1991)
Addis L
(2017)
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue.
in Scientific reports
Adhya D
(2021)
Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids.
in Molecular autism
Adhya D
(2021)
Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.
in Biological psychiatry
Adhya D
(2018)
Understanding the role of steroids in typical and atypical brain development: Advantages of using a "brain in a dish" approach
in Journal of Neuroendocrinology
Agarwal SM
(2021)
Editorial: Cardiovascular and Physical Health in Severe Mental Illness.
in Frontiers in psychiatry
Ahmad J
(2022)
From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.
in Translational psychiatry
Ahmed M
(2021)
The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.
in Communications biology
Ahmed MU
(2017)
Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.
in Developmental biology
Aicha Massrali
(2019)
Chromatin Signaling and Neurological Disorders
Ajram LA
(2019)
The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism.
in Progress in neuro-psychopharmacology & biological psychiatry
Amato D
(2017)
Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies
in Neuroscience & Biobehavioral Reviews
Amato D
(2018)
Dopamine, the antipsychotic molecule: A perspective on mechanisms underlying antipsychotic response variability.
in Neuroscience and biobehavioral reviews
Andersen HG
(2020)
Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients.
in Frontiers in neuroscience
Andreae L
(2019)
Brain development in autism: Timing is everything
in Science Translational Medicine
Andreae L
(2018)
Self-sustained seizure inhibition
in Science Translational Medicine
Andreae L
(2018)
Cannabis use and schizophrenia: Chicken or egg?
in Science Translational Medicine
Andreae L
(2018)
Neural stem cell therapy: A case of identity
in Science Translational Medicine
Andreae L
(2018)
Stressed out? Making new, but different, neurons
in Science Translational Medicine
Andreae L
(2018)
Adult neurogenesis in humans: Dogma overturned, again and again?
in Science Translational Medicine
Andreae LC
(2018)
The role of spontaneous neurotransmission in synapse and circuit development.
in Journal of neuroscience research
Andreae LC
(2018)
Sex bias in autism: new insights from Chd8 mutant mice?
in Nature neuroscience
Andreae LC
(2018)
FENS-Kavli winter symposium: Review and perspectives on neurological diseases.
in The European journal of neuroscience
Andrews DS
(2018)
Using Pattern Classification to Identify Brain Imaging Markers in Autism Spectrum Disorder.
in Current topics in behavioral neurosciences
Andrews DS
(2017)
In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.
in Cerebral cortex (New York, N.Y. : 1991)
Andrzejak RG
(2023)
Seizure forecasting: Where do we stand?
in Epilepsia
Antinucci P
(2018)
Orientation-Selective Retinal Circuits in Vertebrates.
in Frontiers in neural circuits
Antoniades M
(2018)
Verbal learning and hippocampal dysfunction in schizophrenia: A meta-analysis.
in Neuroscience and biobehavioral reviews
Appiah-Kusi E
(2017)
Do cognitive schema mediate the association between childhood trauma and being at ultra-high risk for psychosis?
in Journal of psychiatric research
Arichi T
(2024)
Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.
in Cold Spring Harbor perspectives in biology
Armstrong EC
(2020)
Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: Social and communication deficits in mice with Neurexin 1a deletion.
in Genes, brain, and behavior
Arulkumaran S
(2020)
MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants.
in AJNR. American journal of neuroradiology
Asaridou M
(2024)
Could Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females.
in Journal of autism and developmental disorders
Ashok A
(2019)
Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging
in Nature Communications
Ashok AH
(2019)
Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.
in Psychopharmacology
Ashok AH
(2017)
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment.
in Molecular psychiatry
Ashwood KL
(2016)
Predicting the diagnosis of autism in adults using the Autism-Spectrum Quotient (AQ) questionnaire.
in Psychological medicine
Badodi S
(2017)
Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.
in Cell reports
Ball G
(2017)
Multimodal image analysis of clinical influences on preterm brain development.
in Annals of neurology
Ball G
(2020)
Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain.
in PLoS biology
Title | Engagement of pain-related brain microstates across the final trimester of gestation in human neonates |
Description | Infants have strong cortical responses to a noxious stimulus from 28 weeks postmenstrual age (PMA), however, the cortical substrate required for nociceptive processing undergoes dramatic changes over the equivalent of the last trimester of gestation and increases in complexity potentially with a sexually dimorphic trajectory. In this study, we aim to map the functional development in the serial cortical processing of a clinically required noxious procedure in male and female preterm and term neonates over the equivalent of the last trimester of gestation. |
Type Of Art | Film/Video/Animation |
Year Produced | 2023 |
URL | https://figshare.com/articles/poster/Engagement_of_pain-related_brain_microstates_across_the_final_t... |
Title | NeuroArt |
Description | Collaboration with neurodivergent artists and the Wellcome Trust to produce art around the theme neurodiversity. |
Type Of Art | Artwork |
Year Produced | 2023 |
Impact | To be updated following exhibition |
Title | Synaptic |
Description | Sunnydown Synaptic is an innovative outreach project & exhibition which brought together neuroscience, electronic engineering and visual arts for a dynamic series of workshops with students from Sunnydown School in Surrey. A glass and light installation - Synaptic - in the Old Operating Theatre's Herb Garret, arising from the workshop programme, was open to the public from November 2021 - January 2022 |
Type Of Art | Artistic/Creative Exhibition |
Year Produced | 2021 |
Impact | Members of the public seeing the art and beauty in science |
Description | Coalition for Aligning Science (CAS) Autism Research Roadmap |
Geographic Reach | North America |
Policy Influence Type | Participation in a guidance/advisory committee |
Description | Consultant for the Science Media Centre |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a guidance/advisory committee |
URL | https://www.sciencemediacentre.org/ |
Guideline Title | NICE for pain management |
Description | Contribution to the report commission from the International Pain Research Society by the UK Government on the efficacy of cannabinoids on the treatment of pain |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in clinical guidelines |
Description | Health Sciences Doctoral Training Centre |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Better professional and careers development |
Description | House of Lords Select Committee on Preterm Birth |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Description | Interview with Oscar Marin on impact of Brexit on science |
Geographic Reach | Europe |
Policy Influence Type | Citation in other policy documents |
Impact | Publication in one of the world's leading scientific publications of an interview with Oscar Marin on the impact Brexit is having on science |
URL | https://www.sciencemag.org/news/2018/12/looming-parliament-vote-boosts-brexit-jitters-uk-scientists |
Description | Invited expert for the European Food Safety Authority (EFSA) reviewing the evidence on the safety of brominated flame retardants. |
Geographic Reach | Europe |
Policy Influence Type | Participation in a guidance/advisory committee |
Description | London Mayor Drug Commission |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Participation in a guidance/advisory committee |
Impact | Provide evidence based data that can be translate into public education campaigns and public policies to inform about the risk of heavy cannabis use, which remains the most commonly used illicit recreational drug now also used widely for medicinal reason. |
URL | https://www.london.gov.uk/programmes-strategies/mayors-office-policing-and-crime-mopac/mopac-governa... |
Description | Membership of working body convened by the NC3Rs |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a guidance/advisory committee |
URL | https://nc3rs.org.uk/our-portfolio/rodent-high-yield-behavioural-experiments |
Description | Royal College of Obstetrics and Gynaecology: Fetal Awareness: Review of Research and Recommendations for Practice |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
URL | https://www.rcog.org.uk/en/guidelines-research-services/guidelines/fetal-awareness---review-of-resea... |
Description | The Top Ten UK research priorities for interventions in childhood neurological disorders: A British Paediatric Neurology Association and JLA Priority Setting Partnership |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Description | 'To live or die: early fate decision of cortical interneurons.' |
Amount | £32,742 (GBP) |
Funding ID | 110299/Z/15/A |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2018 |
End | 11/2020 |
Description | (AIMS-2-TRIALS) - Autism Innovative Medicine Studies - 2 - Trials |
Amount | € 113,274,915 (EUR) |
Funding ID | 777394 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 05/2018 |
End | 05/2023 |
Description | (AIMS-2-TRIALS) - Autism Innovative Medicine Studies - 2 - Trials |
Amount | € 113,274,914 (EUR) |
Funding ID | 777394 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 05/2018 |
End | 05/2023 |
Description | (CorCir) - Cortical circuit assembly in the developing mouse neocortex |
Amount | € 183,455 (EUR) |
Funding ID | 705311 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 07/2017 |
End | 08/2019 |
Description | (EXPERIENTIA) - Assembly and plasticity of inhibitory cortical networks by early learning experience |
Amount | € 2,499,990 (EUR) |
Funding ID | 885184 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2021 |
End | 12/2025 |
Description | 3D Volume Serial Block Face Imaging Facility. |
Amount | £602,744 (GBP) |
Funding ID | 108461/Z/15/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2016 |
End | 11/2021 |
Description | 787355 DEVINCI - Developmental principles for the functional specialisation of inhibitory circuits in neocortical areas |
Amount | € 2,500,000 (EUR) |
Funding ID | 787355 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 06/2018 |
End | 06/2023 |
Description | A super-resolution microscopy platform for imaging cells at multiple spatial scales |
Amount | £505,348 (GBP) |
Funding ID | BB/X019845/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2023 |
End | 07/2024 |
Description | AIMS-2-TRIALS: Autism Innovative Medicine Studies - 2 - Trials |
Amount | £43,999,999 (GBP) |
Funding ID | 777394 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 05/2018 |
End | 05/2023 |
Description | AMBROSIC: A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition |
Amount | £209,206 (GBP) |
Funding ID | MR/N029488/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2016 |
End | 02/2018 |
Description | ATLANTIS: AnTiconvuLsant AugmeNtation Trial In Schizophrenia |
Amount | £1,788,651 (GBP) |
Funding ID | NIHR127755 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2020 |
End | 08/2024 |
Description | Assembly and organisation of inhibitory networks in the cerebral cortex |
Amount | £2,168,936 (GBP) |
Funding ID | 202758/Z/16/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2017 |
End | 07/2024 |
Description | Assembly and organisation of inhibitory networks in the cerebral cortex |
Amount | £216,893,600 (GBP) |
Funding ID | 202758/Z/16/Z |
Organisation | Wellcome Trust |
Department | Wellcome Trust Senior Investigator Award |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2017 |
End | 07/2022 |
Description | AstraZeneca UK Limited Default Scheme |
Amount | £291,193 (GBP) |
Organisation | AstraZeneca |
Sector | Private |
Country | United Kingdom |
Start | 04/2021 |
End | 05/2024 |
Description | Autism Innovative Medicine Studies - 2 - Trials (Roche) |
Amount | £1,409,908 (GBP) |
Organisation | F. Hoffmann-La Roche AG |
Sector | Private |
Country | Global |
Start | 08/2021 |
End | 05/2023 |
Description | Building on Brains for Dementia Research (BDR): A UK Nervous Tissue Network (UKNTN) for the Twenty-first Century |
Amount | £1,855,571 (GBP) |
Funding ID | MR/X004112/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2022 |
End | 09/2025 |
Description | Can learning deficits in neurodevelopmental disorders be reversed by restoring gene function in the adult brain? |
Amount | £497,499 (GBP) |
Funding ID | MR/V013173/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2021 |
End | 07/2023 |
Description | Changing Agendas on Sleep, Treatment and Learning in Childhood Epilepsy (CASTLE) |
Amount | £2,619,007 (GBP) |
Funding ID | RP-PG-0615-20007 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 05/2017 |
End | 05/2024 |
Description | Circuit and stage specific rules for activity in neuronal wiring |
Amount | £428,594 (GBP) |
Funding ID | BB/T004800/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2021 |
End | 01/2024 |
Description | Circuit mechanisms of cognitive control |
Amount | £1,310,952 (GBP) |
Funding ID | 206222/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2018 |
End | 06/2024 |
Description | Clinical Research Fellowship |
Amount | £487,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2018 |
End | 02/2021 |
Description | Collaboration Award |
Amount | £75,000 (GBP) |
Organisation | George Washington University |
Sector | Academic/University |
Country | United States |
Start | 03/2017 |
End | 03/2018 |
Description | Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy (CANDY) |
Amount | £683,000 (GBP) |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start | 01/2020 |
End | 12/2024 |
Description | Context-dependent RNA regulation and its application in auto-gating therapeutics for brain disorders |
Amount | £5,844,961 (GBP) |
Funding ID | 227465/Z/23/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2023 |
End | 08/2031 |
Description | Cryo focussed ion beam scanning electron microscope for correlative functional studies of biological systems in situ by tomography |
Amount | £820,000 (GBP) |
Funding ID | 212916 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2018 |
End | 09/2023 |
Description | Decoding the temporal structure of cortical interneuron lineages in mouse and human |
Amount | £2,268,545 (GBP) |
Funding ID | 215556/Z/19/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2020 |
End | 12/2025 |
Description | Decoding the temporal structure of cortical interneuron lineages in mouse and human |
Amount | £2,268,545 (GBP) |
Funding ID | 215556/Z/19/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2020 |
End | 12/2024 |
Description | Deconstructing in vivo glia-to-neuron conversion |
Amount | € 212,933 (EUR) |
Funding ID | 101030217 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 08/2022 |
End | 08/2024 |
Description | Determining the molecular mechanisms of psychosis and developing a cellular platform for novel drug discovery: From brain to cell and back again |
Amount | £30,000 (GBP) |
Funding ID | SGL025\1087 |
Organisation | Academy of Medical Sciences (AMS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2024 |
Description | Developing responsible neurotechnology for infants and children with neurodevelopmental conditions |
Amount | £1,048,588 (GBP) |
Funding ID | EP/W035154/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2022 |
End | 05/2025 |
Description | Developing responsible neurotechnology for infants and children with neurodevelopmental conditions |
Amount | £1,065,728 (GBP) |
Funding ID | EP/W035154/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2022 |
End | 08/2025 |
Description | Development of brain activity and motor control in early human life |
Amount | £1,105,145 (GBP) |
Funding ID | MR/P008712/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 05/2021 |
Description | Developmental principles for the functional specialisation of inhibitory circuits in neocortical areas |
Amount | £1,975,000 (GBP) |
Funding ID | 787355 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 08/2018 |
End | 08/2023 |
Description | Dissecting neural networks with optogenetic functional MRI (opto-fMRI) |
Amount | £292,748 (GBP) |
Funding ID | 212934/Z/18/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2019 |
End | 12/2024 |
Description | Does COVID-19 affect the brain? |
Amount | £25,000 (GBP) |
Funding ID | M970 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 02/2021 |
End | 02/2022 |
Description | EU Marie Curie Fellowship- Alice Petty |
Amount | £224,781 (GBP) |
Organisation | European Union |
Sector | Public |
Country | European Union (EU) |
Start | 11/2021 |
End | 11/2023 |
Description | EU Marie Curie Fellowship- Garzia Rutigliano |
Amount | £326,371 (GBP) |
Organisation | European Union |
Sector | Public |
Country | European Union (EU) |
Start | 08/2021 |
End | 08/2023 |
Description | Early Predictors of Neurodevelopmental Outcomes (MRI) |
Amount | $1,228,683 (USD) |
Funding ID | INV-005774 |
Organisation | Bill and Melinda Gates Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 06/2020 |
End | 05/2022 |
Description | Evolutionary mechanisms controlling brain size and complexity |
Amount | £687,921 (GBP) |
Funding ID | BB/S001530/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 08/2021 |
Description | Fetus 2 Five: a ground breaking new approach to perinatal brain injury and its consequences |
Amount | £1,000,000 (GBP) |
Organisation | Garfield Weston Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2023 |
End | 12/2024 |
Description | Functional Genomics clusters Initiative 2023 |
Amount | £4,000,000 (GBP) |
Funding ID | MR/Y012968/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2024 |
End | 05/2028 |
Description | Germany: Creation of new tools to study the development of the human retina in a dish |
Amount | £13,069 (GBP) |
Funding ID | BB/T020016/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 09/2023 |
Description | Imaging Focal Epilepsy in Children: A Developmental Perspective |
Amount | £995,096 (GBP) |
Funding ID | 206675/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2018 |
End | 07/2025 |
Description | Imaging visuomotor transformations in the brain |
Amount | £1,600,547 (GBP) |
Funding ID | 204788/Z/16/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 02/2017 |
End | 04/2023 |
Description | Improving paediatric clinical neuroimaging with high field 7-tesla Magnetic Resonance Imaging |
Amount | £78,000 (GBP) |
Organisation | King’s Health Partners |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2019 |
End | 02/2021 |
Description | In vivo imaging genesis and circuit integration of interneurons engineered from glia |
Amount | € 2,143,826 (EUR) |
Funding ID | 101021560 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 01/2022 |
End | 12/2026 |
Description | In-vivo MRS measurement of GABA in infants at high risk of neurodevelopmental disorders |
Amount | £199,968 (GBP) |
Funding ID | 2728 |
Organisation | Action Medical Research |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2018 |
End | 12/2022 |
Description | Innovative Medicines Initiative |
Amount | € 117,000,000 (EUR) |
Organisation | European Union |
Sector | Public |
Country | European Union (EU) |
Start | 03/2018 |
End | 04/2023 |
Description | Integrating psychological models with biological pathways in psychosis |
Amount | £980,994 (GBP) |
Funding ID | MR/W027720/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2022 |
End | 10/2027 |
Description | Investigating polyamines as a treatment target for mitochondrial disease |
Amount | £559,164 (GBP) |
Funding ID | MR/V013130/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2021 |
End | 05/2025 |
Description | King's PhD Programme in Mental Health Research for Health Professionals |
Amount | £7,831,772 (GBP) |
Funding ID | 223486/Z/21/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2022 |
End | 09/2029 |
Description | Light sheet microscope for 3D imaging of large samples and improved in vivo imaging |
Amount | £414,588 (GBP) |
Funding ID | 208373/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2018 |
End | 08/2023 |
Description | Lineage reprogramming of glia into subtype-specific cortical neurons |
Amount | £2,600,000 (GBP) |
Funding ID | 206410/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2023 |
Description | Lineage reprogramming of glia into subtype-specific cortical neurons |
Amount | £2,152,997 (GBP) |
Funding ID | 206410 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2023 |
Description | Linking genotype to phenotype in autism: mechanisms of cell-type specific presynaptic dysfunction in Chd8 haploinsufficiency |
Amount | £507,052 (GBP) |
Funding ID | MR/X010481/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2023 |
End | 05/2026 |
Description | Linking the mechanisms generating protein and cortical cell diversity |
Amount | £215,742 (GBP) |
Funding ID | RPG-2022-190 |
Organisation | The Leverhulme Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2023 |
End | 08/2026 |
Description | Long term neurological sequelae following paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV2 (PIM-TS) |
Amount | £282,725 (GBP) |
Funding ID | VC1421 |
Organisation | Great Ormond Street Hospital Children's Charity (GOSHCC) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2021 |
End | 07/2022 |
Description | MICA: Targeting neuro-inflammation in Schizophrenia |
Amount | £891,195 (GBP) |
Funding ID | MR/N027078/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2022 |
Description | MLC National Mouse Genetics Network |
Amount | £3,500,000 (GBP) |
Funding ID | MC_PC_21047 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 03/2027 |
Description | MRC Centre for Neurodevelopmental Disorders |
Amount | £1,467,740 (GBP) |
Funding ID | MR/N026063/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2016 |
End | 10/2022 |
Description | MRC Centre for Neurodevelopmental Disorders: Seed grant |
Amount | £50,000 (GBP) |
Funding ID | MR/N026063/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2017 |
End | 10/2018 |
Description | MRI Neuromodelling |
Amount | $1,998,858 (USD) |
Funding ID | INV-047885 |
Organisation | Bill and Melinda Gates Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 02/2023 |
End | 08/2025 |
Description | MSCF Fellowship- Frederike Winkel Understanding And Manipulating The Dysregulation Of Interneurons In Schizophrenia |
Amount | € 212,933 (EUR) |
Funding ID | 101023993 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 04/2021 |
End | 04/2023 |
Description | MURIDAE - Modalities for Understanding, Recording and Integrating Data Across Early life |
Amount | £360,236 (GBP) |
Funding ID | MC_PC_21041 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 03/2027 |
Description | MURIDAE - Modalities for Understanding, Recording and Integrating Data Across Early life |
Amount | £2,000,000 (GBP) |
Funding ID | MC_PC_21041 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 03/2027 |
Description | Maternal Immune Activation: advancing from rodents to humans through a development of a hIPSC model to study gene x environment interactions |
Amount | £99,031 (GBP) |
Funding ID | NC/S001506/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2023 |
Description | Mechanism of autophagy-controlled axon branching |
Amount | £490,552 (GBP) |
Funding ID | BB/T013753/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2020 |
End | 05/2024 |
Description | Mechanisms underpinning human neocortical development and neurodevelopmental disorders: The novel role of Extracellular Matrix. |
Amount | £1,431,686 (GBP) |
Funding ID | MR/S025065/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2019 |
End | 05/2024 |
Description | Mind & Skin: Understanding the neurocutaneous axis in atopic eczema |
Amount | £515,168 (GBP) |
Funding ID | MRF-176-0002-RG-FLOH-C0929 |
Organisation | Medical Research Council (MRC) |
Department | Medical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2022 |
End | 05/2027 |
Description | Modulation of serotonin pathways using psilocybin in adults with and without Autism Spectrum |
Amount | £700,000 (GBP) |
Organisation | COMPASS Pathways Ltd |
Sector | Private |
Country | United Kingdom |
Start | 03/2021 |
End | 09/2023 |
Description | Molecular Mechanisms Underlying Homeostatic Plasticity Of PV+ Interneurons |
Amount | £12,162,131 (GBP) |
Funding ID | PGL21/10159 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2021 |
End | 11/2023 |
Description | Molecular mechanisms underlying homeostatic plasticity of PV+ interneurons |
Amount | £121,622 (GBP) |
Funding ID | PGL21 10159 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2021 |
End | 11/2023 |
Description | Multi-modal dissection of neural circuits in health and disease |
Amount | £427,144 (GBP) |
Funding ID | MC_PC_MR/Y00230X/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2023 |
End | 03/2024 |
Description | NA |
Amount | £330,000 (GBP) |
Organisation | Bit.Bio |
Sector | Private |
Country | United Kingdom |
Start | 01/2023 |
End | 12/2025 |
Description | NARSAD Independent Investigator Award |
Amount | $100,000 (USD) |
Funding ID | 25957 |
Organisation | Brain & Behaviour Research Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 08/2017 |
End | 09/2019 |
Description | NIHR Senior Investigator |
Amount | £75,000 (GBP) |
Funding ID | NF-SI-0616-10122 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2022 |
Description | Neocortical Feedback Supporting Familiarity |
Amount | £433,820 (GBP) |
Funding ID | BB/S008276/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2020 |
End | 01/2023 |
Description | Neural circuit basis of flexible behaviour |
Amount | £3,443,729 (GBP) |
Funding ID | 227340/Z/23/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2023 |
End | 06/2031 |
Description | Neural circuits underlying attentional modulation in mouse visual cortex |
Amount | £473,272 (GBP) |
Funding ID | BB/S015809/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 12/2019 |
End | 06/2023 |
Description | Neurodevelopment from the fetus to childhood in individuals with congenital heart disease |
Amount | £3,453,853 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 02/2026 |
Description | Neuroimaging Dimensions at the Extremes of the Schizophrenia Spectrum |
Amount | $3,700,548 (USD) |
Funding ID | 1R01MH134526-01 |
Organisation | National Institute of Mental Health |
Sector | Public |
Country | United States |
Start | 08/2023 |
End | 08/2028 |
Description | Neuronal identity and numbers in the development of neocortical activity |
Amount | £300,000 (GBP) |
Funding ID | 222822/Z/21/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2021 |
End | 05/2025 |
Description | Novel Function of Splicing factors in Establishment and Maintenance of Neuronal Connectivity |
Amount | £642,144 (GBP) |
Funding ID | BB/P001599/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2017 |
End | 09/2020 |
Description | Pathway-driven identification of therapeutic targets for combatting Alzheimer's disease. |
Amount | £1,000,906 (GBP) |
Funding ID | MR/M013944/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2015 |
End | 11/2018 |
Description | PhD Scholarship |
Amount | £167,000 (GBP) |
Organisation | Kuwait University |
Sector | Academic/University |
Country | Kuwait |
Start | 02/2023 |
End | 01/2026 |
Description | Post-transcriptional regulation in motor and cognitive disorders |
Amount | £785,765 (GBP) |
Funding ID | MR/T033126/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2020 |
End | 06/2024 |
Description | Precision Modelling of Cortical Variation and its Association with Neurological/Psychiatric disease |
Amount | £537,145 (GBP) |
Funding ID | MR/V03832X/1 |
Organisation | King's College London |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2024 |
Description | Predictive impairment in autism: towards the emergence of phenotypes |
Amount | £190,380 (GBP) |
Funding ID | EP/X021947/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2023 |
End | 03/2025 |
Description | Prenatal inflammation and neurodevelopmental disorders |
Amount | £250,000 (GBP) |
Organisation | Dr Mortimer and Theresa Sackler Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2020 |
End | 03/2026 |
Description | Prenatal vitamin D, neonatal brain development and neurodevelopmental outcomes of infants |
Amount | £55,005 (GBP) |
Organisation | The Waterloo Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2019 |
End | 02/2020 |
Description | Preventing disorders and discovering new treatments |
Amount | £1,468,852 (GBP) |
Organisation | Dr Mortimer and Theresa Sackler Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2019 |
End | 12/2027 |
Description | Proximity to Discovery Industry Engagement Fund |
Amount | £29,960 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2018 |
End | 06/2018 |
Description | Rare Diseases Node |
Amount | £1,250,000 (GBP) |
Funding ID | MR/Y008170/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2023 |
End | 11/2028 |
Description | Reducing the harmful effects of cannabis use: finding the optimal CBD:THC ratio |
Amount | £385,741 (GBP) |
Funding ID | MR/P006841/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 02/2020 |
Description | Regulation of cortical interneuron wiring in neurodevelopmental disorders |
Amount | £217,554 (GBP) |
Funding ID | 736666 |
Organisation | Simons Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 11/2020 |
End | 10/2022 |
Description | Regulation of cortical interneuron wiring in neurodevelopmental disorders |
Amount | $299,806 (USD) |
Funding ID | 736666 |
Organisation | Simons Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 11/2020 |
End | 10/2022 |
Description | Relating structure to function: Development of dendritic arborisations underlying orientation selectivity in the vertebrate visual system |
Amount | £571,829 (GBP) |
Funding ID | BB/R000972/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2018 |
End | 05/2021 |
Description | Role of VGF in cortical PV+ interneuron interconnectivity |
Amount | £831,208 (GBP) |
Funding ID | BB/Y001958/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 12/2023 |
End | 11/2026 |
Description | Role of distinct cortical progenitor subtypes in cortical neuronal and glial subtype specification |
Amount | £529,216 (GBP) |
Funding ID | BB/W015137/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2023 |
End | 08/2026 |
Description | Roles of intron retention and splicing factors in axons |
Amount | £1,500,000 (GBP) |
Funding ID | 220861/Z/20/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2020 |
End | 08/2025 |
Description | STOP- Successful Treatment Of Paranoia: Replacing harmful paranoid thoughts with better alternatives |
Amount | £1,822,901 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 02/2025 |
Description | Seed Funding |
Amount | £50,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2017 |
End | 09/2018 |
Description | Senior Clinical Fellowship: Exploration of cortical structure and function in human infancy with advanced MRI methods |
Amount | £2,138,568 (GBP) |
Funding ID | MR/Y009665/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2024 |
End | 03/2029 |
Description | Sensory biomarkers of core and associated symptoms of autism in preschool children with autism |
Amount | $700,000 (USD) |
Organisation | Simons Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 05/2022 |
End | 05/2025 |
Description | Simons Foundation Autism Research Initiative-Director |
Amount | $150,011 (USD) |
Funding ID | Award ID: 653443 |
Organisation | Simons Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 09/2019 |
End | 09/2020 |
Description | Simons Foundation Default Scheme |
Amount | £522,682 (GBP) |
Organisation | Simons Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 01/2022 |
End | 12/2025 |
Description | Stress and GABA in the pathogenesis of psychosis |
Amount | £1,089,387 (GBP) |
Funding ID | 202397 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2022 |
Description | Synaptic mRNA dysregulation in Neurodevelopmental Disorders |
Amount | £692,950 (GBP) |
Funding ID | 225685/Z/22/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2023 |
End | 02/2028 |
Description | The Resilient Brain. Imaging Biomarkers of Brain Metabolic Reserve |
Amount | £452,468 (GBP) |
Funding ID | BB/N009088/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 12/2016 |
End | 11/2019 |
Description | The emergence and plasticity of a balance between excitation and inhibition along dendrites |
Amount | £649,433 (GBP) |
Funding ID | BB/S000526/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 09/2022 |
Description | The emergence and plasticity of a balance between excitation and inhibition along dendrites |
Amount | £649,432 (GBP) |
Funding ID | BB/S000526/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 09/2022 |
Description | The emergence of GABAergic microcircuits in the cortex |
Amount | £2,214,114 (GBP) |
Funding ID | 215508/Z/19/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2019 |
End | 05/2025 |
Description | The emergence of GABAergic microcircuits in the cortex |
Amount | £2,214,114 (GBP) |
Funding ID | 215508 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2019 |
End | 05/2024 |
Description | The role of late onset Alzheimer's disease risk genes in synaptoxicity |
Amount | £109,551 (GBP) |
Funding ID | ARUK-PhD2016-4 |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2016 |
End | 10/2019 |
Description | The role of neurotransmitter release in synapse formation |
Amount | £330,712 (GBP) |
Funding ID | BB/P000479/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 10/2020 |
Description | To live or die: early fate decision of cortical interneurons. |
Amount | £250,000 (GBP) |
Funding ID | 110299/Z/15/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2016 |
End | 09/2019 |
Description | UK Human Developmental Biology Initiative |
Amount | £5,000,000 (GBP) |
Funding ID | 215116/A/18/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2019 |
End | 10/2025 |
Description | UK Human Developmental Biology Initiative, Neuroscience theme |
Amount | £31,445,934 (GBP) |
Funding ID | 215116/Z/18/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 10/2025 |
Description | Understanding neurodevelopment in mosaic chromatin disorders using in vitro and ex vivo models of brain development |
Amount | £249,878 (GBP) |
Funding ID | V4723 |
Organisation | Great Ormond Street Hospital Children's Charity (GOSHCC) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2023 |
End | 05/2026 |
Description | Understanding the contribution of cortical interneuron dysfunction to schizophrenia |
Amount | £2,046,740 (GBP) |
Funding ID | MR/S010785/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2019 |
End | 04/2024 |
Description | Understanding the contribution of cortical interneuron dysfunction to schizophrenia |
Amount | £2,046,740 (GBP) |
Funding ID | MR/S010785/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2019 |
End | 05/2024 |
Description | Understanding the contribution of cortical interneurons dysfunction to schizophrenia |
Amount | £2,046,740 (GBP) |
Funding ID | MR/S010785/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2019 |
End | 04/2024 |
Description | Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes |
Amount | £852,347 (GBP) |
Funding ID | 10053515 (101057390 - HappyMums) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 11/2022 |
End | 09/2026 |
Description | World Class Labs Capital Funding |
Amount | £179,561 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2020 |
End | 03/2021 |
Title | Antipsychotic decision aid tool |
Description | Tool to help patients make decisions about treatment |
Type Of Material | Model of mechanisms or symptoms - human |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | Taken up for use in the NHS |
Title | High Content Synapse Assay |
Description | This assay has been developed to assess the potential neuroprotective or neurorestorative of compounds against the synaptotoxic effects of amyloid beta on synapse number. It uses mature primary cortical cultures as platform from which to screen for protective compounds. It allows for the screening of a large number of compounds and the automated analysis of data. |
Type Of Material | Technology assay or reagent |
Year Produced | 2016 |
Provided To Others? | No |
Impact | We have used this methodology to screen over 80 compounds for their neuroprotective properties as part of a larger collaboration with researchers in the SMART-AD project. This has helped to identify 6 compounds (also identified from other screens) that are now being tested further within in vivo models. |
Title | PSC-derived neural polarised 3D culture |
Description | Establishment of a new approach to impose tissue organisation to telencephalon organoids using cryogels. |
Type Of Material | Technology assay or reagent |
Year Produced | 2020 |
Provided To Others? | No |
Impact | Just starting |
Title | Sulfonated cryogel scaffolds for focal delivery in ex-vivo brain tissue cultures |
Description | We have developed an easy-to-use tool for site-specific manipulation of human brain tissue in culture. We show that line-shaped cryogel scaffolds synthesized with precise microscale dimensions allow the targeted delivery of a reagent to a specific region of human brain tissue in culture. 3-sulfopropyl acrylate (SPA) was incorporated into the cryogel network to yield a negative surface charge for the reversible binding of molecular cargo. The fluorescent dyes BODIPY and DiI were used as model cargos to show that placement of dye loaded scaffolds onto brain tissue in culture resulted in controlled delivery without a burst release, and labelling of specific regions without tissue damage. We further show that cryogels can deliver tetrodotoxin to tissue, inhibiting neuronal function in a reversible manner. The robust nature and precise dimensions of the cryogel resulted in a user-friendly and reproducible tool to manipulate primary human tissue cultures. These easy-to-use cryogels offer an innovate approach for more complex manipulations of ex-vivo tissue. |
Type Of Material | Technology assay or reagent |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | We have developed a novel biomaterial-based tool that can be used to manipulate tissue explant cultures in a precise and reproducible manner with both spatial and temporal control. These cryogels have great potential to be modified and used to deliver a wide variety of reagents to primary tissue, allowing efficient and timely manipulation of cellular function. In particular, the efficient and reversible electrostatic loading/release paradigm transforms these synthetically sulfonated line-shaped microcryogels into a useful, biocompatible, and easy-to-handle tool to control reagent delivery. Both the degree of sulfonation and the presence of other charged groups could be adapted for specific cargos, such as pharmacological inhibitors or recombinant proteins. These cryogels are of particular interest for researchers working with ex vivo model systems where genetic tools are lacking, such as primary human tissue, but could be also applied in many different fields. |
URL | https://www.sciencedirect.com/science/article/pii/S0142961221000636?dgcid=rss_sd_all |
Title | Additional file 2 of Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin |
Description | Additional file 2. Table S3. Baseline striatal functional connectivity in the neurotypicals. Table displays statistics for targets (regions containing the cluster peak), including cluster size (in voxels), T-value (T-val), FDR-corrected significance level (pFDR), and peak coordinates in Montreal Neurological Institute (MNI) space (x,y,z). Abbreviations: DC, dorsal caudate; dcP, dorsal-caudal putamen; drP, dorsal-rostral putamen; L, left; R, right; ROI, region of interest; vrP, ventralrostral putamen; VSi, inferior ventral striatum; VSs, superior ventral striatum. Table S4. Baseline striatal functional connectivity in the ASD group. Table displays statistics for targets (regions containing the cluster peak), including cluster size (in voxels), T-value (T-val), FDR-corrected significance level (pFDR), and peak coordinates in Montreal Neurological Institute (MNI) space (x,y,z). Abbreviations: DC, dorsal caudate; dcP, dorsal-caudal putamen; drP, dorsal-rostral putamen; L, left; R, right; ROI, region of interest; vrP, ventralrostral putamen; VSi, inferior ventral striatum; VSs, superior ventral striatum. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Modulation_of_striatal_fun... |
Title | Additional file 2 of Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin |
Description | Additional file 2. Table S3. Baseline striatal functional connectivity in the neurotypicals. Table displays statistics for targets (regions containing the cluster peak), including cluster size (in voxels), T-value (T-val), FDR-corrected significance level (pFDR), and peak coordinates in Montreal Neurological Institute (MNI) space (x,y,z). Abbreviations: DC, dorsal caudate; dcP, dorsal-caudal putamen; drP, dorsal-rostral putamen; L, left; R, right; ROI, region of interest; vrP, ventralrostral putamen; VSi, inferior ventral striatum; VSs, superior ventral striatum. Table S4. Baseline striatal functional connectivity in the ASD group. Table displays statistics for targets (regions containing the cluster peak), including cluster size (in voxels), T-value (T-val), FDR-corrected significance level (pFDR), and peak coordinates in Montreal Neurological Institute (MNI) space (x,y,z). Abbreviations: DC, dorsal caudate; dcP, dorsal-caudal putamen; drP, dorsal-rostral putamen; L, left; R, right; ROI, region of interest; vrP, ventralrostral putamen; VSi, inferior ventral striatum; VSs, superior ventral striatum. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Modulation_of_striatal_fun... |
Title | Developing Human Connectome Project |
Description | A large collection of brain images from newborn infants and foetuses which allow functional and structural connectivity to be defined, together with clinical and genetic data. Currently 550 subjects collected, target is around 1000. This is now funded by an ERC grant but the preliminary work was carried out by the linked project . |
Type Of Material | Database/Collection of data |
Provided To Others? | No |
Impact | This will be an open source database for researchers to use. The first data release is in 2017 |
URL | http://www.developinghumanconnectome.org |
Title | Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo |
Description | Confocal raw microscopy images (czi) from every figue and analysis done in MS Excel. Zipped data folders include readme files explaining how to navigate them. |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | Data underpinning the ORIGINAL RESEARCH article doi.org/10.3389/fnins.2022.919462 |
URL | https://kcl.figshare.com/articles/dataset/Enhanced_proliferation_of_oligodendrocyte_progenitor_cells... |
Title | Multi-synaptic boutons are a feature of CA1 hippocampal connections that may underlie network synchrony |
Description | This is an open source, recently published model (Rigby et al., Cell Reports, 2023). We model CA1 neurons receiving synaptic input from CA3/2 neurons as well as background input. Inputs were divided into strata (stratum radiatum and SO), and the fraction of MSBs in each was set in accordance with either previously published data for the stratum radiatum (25% MSBs) or with the findings described for the SO (50% MSBs) in Rigby et al. (2023). |
Type Of Material | Computer model/algorithm |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | NA |
URL | https://github.com/juliavg/multi_synaptic_boutons |
Title | Neonatal HERMES MRS data |
Description | MR spectroscopy data collected from 18 infant subjects using the HERMES edited MRS acquisition sequence. Data is available on request and upon completion of a data usage agreement. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | New collaborations with Richard Edden (Johns Hopkins University) and Nicholas Puts (KCL) |
URL | http://www.perinatal-functional-imaging.co.uk/resources |
Title | Preterm brain sensori-motor functional activation maps |
Description | Activation maps derived from fMRI data from groups of preterm infants, aligned to age specific template space. Total of 5 maps showing location of functional responses following somatosensory stimulation of the left wrist, right wrist, left ankle, right ankle, and mouth/lips. Methodology and data set has been described in the paper (Dall'Orso et al. Cerebral Cortex 2018). Group activation maps have been made available for download. |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | As performing these kind of task based fMRI studies is challenging in preterm infants - we have made this data available so it can be used by other researchers to explore functional and structural connectivity in this age group. |
URL | https://brain-development.org/somatotopicmap/ |
Title | Preterm delta brush functional activation maps |
Description | Functional activation maps from a group of preterm infants studied with simultaneous EEG-fMRI. Group maps have been aligned to an age-specific template and have been made available for download. |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | We acknowledge that this is challenging data to collect - we have therefore made it available for download so that other researchers can use the activation maps to explore functional and structural connectivity in this population. |
URL | https://brain-development.org/activation-maps-related-to-spontaneous-delta-brush-activity/ |
Title | Simultaneous EEG data with passive motor stimulus from preterm infants |
Description | Preprocessed EEG data - infants were fitted with neonatal 25-electrode EEG caps (29 - 32 cm head circumference) and connected to an MR-compatible system (EASYCAP and Brain Products GmbH). EEG data preprocessing was performed using Analyzer 2 software (Brain Products GmbH), with an initial 0.2 Hz high-pass filter used to remove slow frequency drift in the EEG data. After exclusion of TRs with visible motion on the raw EEG, MR gradient artifact was cleaned using a 25 TR sliding window template subtraction. A 40 Hz lowpass and 50 Hz notch filter were applied. Electrodes with poor signal or bridged to the reference (FCz) were removed. MRI data were acquired with a 3 Tesla Philips Achieva scanner (Best, Netherlands) and a 32 channel adult head coil. Infants were scanned following feeding, during natural sleep and were fitted with ear protection (molded dental putty and adhesive earmuffs: Minimuffs, Natus Medical Inc, San Carlos CA, USA) and immobilized in a vacuum cushion (Med-Vac, CFI Medical Solutions, Fenton, MI, USA). fMRI data were acquired using T2*-weighted single-shot gradient echo echo-planar imaging (GRE-EPI) sequence (resolution: 2.5*2.5*3.25mm; 21 slices; TE: 30ms; TR: 1500ms, flip angle: 90°, lasting up to 13.5 minutes). A custom-built MR compatible robotic device (Dall'Orso et al., 2018) was fitted to the right wrist to deliver blocks of 1Hz passive right wrist flexion-extension for 7.5 to 10.5 seconds (5 to 7 TRs, up to 24 epochs of stimulation), with a variable inter-stimulus interval (21 to 24 seconds) to minimize anticipatory responses. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
URL | https://figshare.com/articles/dataset/Simultaneous_EEG_data_with_passive_motor_stimulus_from_preterm... |
Title | developing Human Connectome Project data |
Description | The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating normal and abnormal brain development across the perinatal period. It has collected 1228 multimodal magnetic resonance images of fetal and/or neonatal brain from 1173 participants, together with collateral demographic, clinical, family, neurocognitive and genomic data. All subjects were studied in utero and/or soon after birth on a single MRI scanner using specially developed scanning sequences which included novel motion-tolerant imaging methods. Imaging data are complemented by rich demographic, clinical, neurodevelopmental, clinical, and genomic information. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | Data has been downloaded and used widely by peers |
URL | http://www.developingconnectome.org/data-release/third-data-release/ |
Description | A Brain Atlas for the Human Lifespan |
Organisation | University of Cambridge |
Department | Cambridge Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We collaborated on the making of the first lifespan brain atlas- providing fetal and neonatal MRI data |
Collaborator Contribution | other groups provided data and the principal collaborators analysed the datasets |
Impact | Bethlehem et al. Brain charts for the human lifespan. Nature 2022 Apr;604(7906):525-533. doi: 10.1038/s41586-022-04554-y. Epub 2022 Apr 6. |
Start Year | 2021 |
Description | Animal model experiment |
Organisation | King's College London |
Department | MRC Centre for Developmental Neurobiology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Professor Beatriz Rico and Professor Oscar Marin are hosting in their lab facilities and collaborating on the mouse model experiment part of study 4 of this MRC proposal. |
Collaborator Contribution | Our partner are supporting this project by : 1. Hosting the experiment in their lab 2. Providing the mouse model for it 3. The supervision of their post doc who works closely with the RA appointed to run our experiment 4. Their experience in interpreting the findings |
Impact | Too early |
Start Year | 2020 |
Description | Biomaterial tools for human tissue slices |
Organisation | Cardiff University |
Department | School of Pharmacy and Pharmaceutical Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are providing biological expertise and testing of the biomaterials. |
Collaborator Contribution | Our collaborators are providing novel materials and expertise. |
Impact | Recent publication in Biomaterials: 10.1016/j.biomaterials.2021.120712 |
Start Year | 2019 |
Description | Birkbeck college |
Organisation | Birkbeck, University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are working together, through a SImons SFARI foundation grant, to look at sensory processing in preschoolers |
Collaborator Contribution | We work together |
Impact | Nothing yet |
Start Year | 2022 |
Description | Combining diffusion tensor imaging with optical clearing and high-resolution imaging to assess long range connectivity in mouse models for autism |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We carried out the optical clearing and high-resolution imaging and developed new analytical approaches. |
Collaborator Contribution | They carried out the diffusion tensor imaging and its analysis. |
Impact | Pervolaraki E et al - doi: 10.1186/s13229-019-0261-9 Multidisciplinary: DTI magnetic resonance imaging, optical clearing & two-photon high-resolution imaging, computational approaches to 3D analysis |
Start Year | 2017 |
Description | Combining transcriptomic and genomic analyses in cortical neurons |
Organisation | Medical Research Council (MRC) |
Department | MRC Centre for Neuropsychiatric Genetics and Genomics |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have established a collaboration with the MRC Centre for Neuropsychiatric Genetics and Genomics (Michael Owen, Michael O'Donovan and James Walters) to investigate the expression of disease susceptibility genes in specific populations of cortical neurons during brain development. We provide transcriptomics data and expertise in the molecular characterisation of cortical neuronal cell types. |
Collaborator Contribution | We have established a collaboration with the MRC Centre for Neuropsychiatric Genetics and Genomics (Michael Owen, Michael O'Donovan and James Walters) to investigate the expression of disease susceptibility genes in specific populations of cortical neurons during brain development. They provide genomics data and expertise in the identification of disease susceptibility genes for neurodevelopmental disorders. |
Impact | Analysis of results still ongoing. |
Start Year | 2019 |
Description | Comparative analyses of Genome wide DNA methylation changes associated with cannabinoids exposure in human and mice. |
Organisation | Mount Sinai Hospital |
Country | United States |
Sector | Hospitals |
PI Contribution | Professor Yasmin Hurd is the Ward-Coleman Chair of Translational Neuroscience and the Director of the Addiction Institute, Mount Sinai University New York, USA. Professor Hurd is the world leading expert in the effects on the epigenome of perinatal and pubertal exposure to cannabinoids in rodents. We are designing the animal model experiment part of this award in collaboration with her team who will also jointly analyses with us the epigenetic data, we plan to generate. |
Collaborator Contribution | Our partner contribution include: 1. Regular meeting to advise on the epigenetic component of the animal model experiment 2. Supervision and collaboration on the comparative analyses looking at the blood epigenetic changes associated human and mice exposure to cannabinoids and with those from the mice brain tissue |
Impact | Too early |
Start Year | 2020 |
Description | Deciphering mechanisms of altered neurodevelopment in BAF complex intellectual disability disorders |
Organisation | Francis Crick Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Intellectual input, training of staff and expertise in stem cell biology. |
Collaborator Contribution | Intellectual input and training of staff. |
Impact | None yet. |
Start Year | 2017 |
Description | Development of novel light sheet microscopes for imaging of synapses within intact tissue |
Organisation | M Squared Lasers Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Materials, Intellectual input and expertise in synapse and stem cell biology. |
Collaborator Contribution | Training of staff, access to novel materials and instruments, intellectual input. |
Impact | Several papers in preparation; Institute of Physics innovation award |
Start Year | 2016 |
Description | ECNP Immuno Neuropsychiatry network |
Organisation | European College of Neuropsychopharmacology (ECNP) |
Country | Netherlands |
Sector | Charity/Non Profit |
PI Contribution | This ECNP Network aims to share findings that are transforming our understanding of brain reserve and disease, setting the stage for new classifications and new treatment of neuropsychiatric disorders. My research group using laboratory animal models to perform high-level translational research projects, has enabled us to substantially improve mechanistic and functional knowledge about the exact nature of the relationships of inflammatory state with relevant clinical dimensions, treatment resistance and therefore promote appropriate pharmacological interventions. |
Collaborator Contribution | internationally recognized clinical centers particularly helpful for the development of data bases, pathophysiological and therapeutic studies in humans. |
Impact | PMID: 35235897; 33493625 EU Horizon grant - Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes , HORIZON-HLTH-2021-STAYHLTH-01-02; 10053515 (101057390 - HappyMums) |
Start Year | 2020 |
Description | EU AIMS |
Organisation | European Commission |
Department | Innovative Medicines Initiative (IMI) |
Country | Belgium |
Sector | Public |
PI Contribution | This is an EU IMI initiative in autism. We lead this multicentre research network. This has now transitioned to AIMS-2-TRIALS to run from 2018-2023 in which I am principal investigator. |
Collaborator Contribution | providing a platform for innovative medicine discovery |
Impact | This first initiative from the EU (EU-AIMS) ended after 5 years and a second collaboration AIMS-2-TRIALS involving 48 international partners began in 2018. |
Start Year | 2011 |
Description | EU AIMS |
Organisation | F. Hoffmann-La Roche AG |
Country | Global |
Sector | Private |
PI Contribution | This is an EU IMI initiative in autism. We lead this multicentre research network. This has now transitioned to AIMS-2-TRIALS to run from 2018-2023 in which I am principal investigator. |
Collaborator Contribution | providing a platform for innovative medicine discovery |
Impact | This first initiative from the EU (EU-AIMS) ended after 5 years and a second collaboration AIMS-2-TRIALS involving 48 international partners began in 2018. |
Start Year | 2011 |
Description | Estrogens in health and disease |
Organisation | AstraZeneca |
Department | Astra Zeneca |
Country | United States |
Sector | Private |
PI Contribution | My lab has conducted experiments, provided expertise in synapse biology, intellectual input and training of staff. |
Collaborator Contribution | Our collaborators have have conducted experiments, provided intellectual input, training of staff as well as reagents. |
Impact | We have a joint PhD student funded by BBSRC and several publications either published or under preparation. |
Start Year | 2014 |
Description | FCI |
Organisation | Francis Crick Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New postdoctoral post moved to the FCI as a satellite to the Houart lab. Collaboration of this postdoc with the Guillemot lab at the FCI |
Collaborator Contribution | Sharing facilities and technical platforms. Exchange of expertise between the two institutions |
Impact | Too early for the collaboration to have publication and funding output yet. Development of ambitious human 3D cell culture (organoids) and characterisation of human tissues by staining and scRNAseq. |
Start Year | 2019 |
Description | FCI |
Organisation | Francis Crick Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New postdoctoral post moved to the FCI as a satellite to the Houart lab. Collaboration of this postdoc with the Guillemot lab at the FCI |
Collaborator Contribution | Sharing facilities and technical platforms. Exchange of expertise between the two institutions |
Impact | Too early for the collaboration to have publication and funding output yet. Development of ambitious human 3D cell culture (organoids) and characterisation of human tissues by staining and scRNAseq. |
Start Year | 2019 |
Description | Guy's and St Thomas' NHS Foundation Trust |
Organisation | Evelina London Children's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Installation and use of a new neonatal MRI scanner in the Neonatal Intensive Care Unit of St Thomas' Hospital. We have moved our research group to this site and formed a new strategic alliance between our University (King's College London) and the Trust |
Collaborator Contribution | Infrastructure support |
Impact | New MR scanner and multidisciplinary group which uses this for research and clinical practice. This involves neonatal medicine, physics, computer science and neuroscience as well as cardiology and psychiatry |
Start Year | 2012 |
Description | Human Dev. Neuro Collabortive Satellite |
Organisation | Francis Crick Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | CH led an initiative to develop a collaborative research programme to understand the human property of early CNS development. This collaboration is embedded inside the partnership space of the FCI. The research programme is co-led by James Briscoe, Kate Storey and Francois Guillemot. The ambition proposed by CH is to form an internationally visible hub focused in early stages of human brain and spinal cord development. |
Collaborator Contribution | Our partners at the FCI provide expertise and supervision time as well as equipment to articulate our collaborative objectives. |
Impact | We have developed a new research direction in early human forebrain development and from the expertise acquired we have now two publications in prep and been asked to join the Wellcome trust funded HDBI (see further collab. and further funding) and got funding for two postdoctoral posts to further develop this direction of research. |
Start Year | 2018 |
Description | In vitro models of neurodegeneration |
Organisation | BenevolentAI |
Country | United Kingdom |
Sector | Private |
PI Contribution | We have established a collaborative project with BAI and started to test their small molecule compounds on human i_SC-based models of neurodegenerative disease. |
Collaborator Contribution | So far BAI has contributed a small library of potential ALS drugs to the collaboration. In the future, the collaboration is likely to shift to related fields such as virus-induced CNS degeneration. |
Impact | We have identified several small compounds that promote nerve-muscle connectivity in vitro and represent potential ALS drugs. |
Start Year | 2020 |
Description | Investigating the retrotranscriptome and its role in brain development and stem cell fate |
Organisation | George Washington University |
Country | United States |
Sector | Academic/University |
PI Contribution | Training of staff, intellectual input, expertise in stem cell biology and neuroscience. |
Collaborator Contribution | Training of staff, intellectual input, expertise in virology. |
Impact | Several publications are currently in preparation or are under review. This collaboration is multi-disciplinary including neuroscience and virology. |
Start Year | 2017 |
Description | Linking cell behaviour to progenitor fate in the human embryonic telencephalon |
Organisation | Francis Crick Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We provide our expertise in vertebrate telencephalon early development, intellectual input to the whole network and our long experience in training technicians and postdoctoral fellows. The collaboration includes training of two postdoctoral fellows. We give access to our human cell culture equipment and use of our scRNAseq facility. Our long-standing experience in the field of telencephalon early development from fish to mammals provide a unique evolutionary perspective to the work. |
Collaborator Contribution | Our partners provide the human tissue (HDBR) without which such ambitious project could not be done and the HDBI provides the unique ability to put our findings in the perspective of human development as a whole. |
Impact | Just starting. |
Start Year | 2022 |
Description | Linking cell behaviour to progenitor fate in the human embryonic telencephalon |
Organisation | University College London |
Department | MRC/Wellcome Trust Human Developmental Biology Resource |
Country | United Kingdom |
Sector | Private |
PI Contribution | We provide our expertise in vertebrate telencephalon early development, intellectual input to the whole network and our long experience in training technicians and postdoctoral fellows. The collaboration includes training of two postdoctoral fellows. We give access to our human cell culture equipment and use of our scRNAseq facility. Our long-standing experience in the field of telencephalon early development from fish to mammals provide a unique evolutionary perspective to the work. |
Collaborator Contribution | Our partners provide the human tissue (HDBR) without which such ambitious project could not be done and the HDBI provides the unique ability to put our findings in the perspective of human development as a whole. |
Impact | Just starting. |
Start Year | 2022 |
Description | Mechanisms of sensory discrimination in rodents |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have investigated how disruption of the excitatory-inhibitory cellular balance in the cerebral cortex impacts the learning of sensory discrimination tasks in head-fixed mice. |
Collaborator Contribution | Adil Khan has helped our laboratory to set up sensory discrimination tasks in head-fixed mice. |
Impact | A manuscript is being prepared for publication. |
Start Year | 2018 |
Description | Modelling of circuit dynamics |
Organisation | Imperial College London |
Department | Department of Bioengineering |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We provided the biological data on the properties of multi-synaptic boutons in the hippocampus. |
Collaborator Contribution | Our collaborators used this the biological data to model the effects of multi-synaptic boutons on circuit dynamics |
Impact | A paper was published: Rigby et al., Cell Reports, 2023. |
Start Year | 2023 |
Description | Modelling schizophrenia using patient-specific induced puripotent stem cells. |
Organisation | Icahn School of Medicine at Mount Sinai |
Country | United States |
Sector | Academic/University |
PI Contribution | We are providing intellectual input and training of staff. |
Collaborator Contribution | Our collaborators are providing novel materials. |
Impact | NA |
Start Year | 2018 |
Description | Overlapping and defining Genetic pathway analyses of Cannabis Use and Schizophrenia |
Organisation | Washington University in St Louis |
Country | United States |
Sector | Academic/University |
PI Contribution | Professor Arpana Agrawal leads the PGC SUD group and this collaboration provides statistical support and data access for the analyses done in collaboration to Dr Johnson, see other collaborations |
Collaborator Contribution | Contributions: 1. Data access 2. Findings and paper revision |
Impact | One publication ( see publications list) One in preparation |
Start Year | 2020 |
Description | Psychosis group MRS studies groups Gemma Modinos and Philip McGuire |
Organisation | King's College London |
Department | Institute of Psychiatry, Psychology & Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We generated and provided an interneuron-deficient genetic model that shows schizophrenia-like phenotypes, including changes in cortical activity and cognitive deficits caused by a synaptic phenotype. These mutants have been scanned to detect the levels of GABA and glutamatergic metabolites, an approach that is currently used in humans. The rationale behind this study is to identify biomarkers that can be correlated with specific pathological deficits. We have discussed and provided inputs on the preliminary results obtained with the MRS data. |
Collaborator Contribution | Our colleagues have scanned controls and mutant model on a 9.4T Bruker MR scanner at the BRAIN Centre (King's college London) to detect the levels of GABA and glutamatergic metabolites, an approach that is currently used in humans. |
Impact | The rationale behind this study is to identify biomarkers that can be correlated with specific pathological deficits. For example, changes in specific metabolics in a well-characterised genetic model can informed us that similar changes in metabolics are expected to change in alterations on the same circuitries in humans. This will help to stratify patients for a better drug targeting design. |
Start Year | 2019 |
Description | Psychosis studies: genetic and environment, group of Marta di Forti |
Organisation | King's College London |
Department | Institute of Psychiatry, Psychology & Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | In the cortex of our MRC Programme grant, we are going to text how influence stressors like cannabis in a genetic model with interneuron deficiency. To achieve that we will use THC and CBD to text the positive and negative influence of these compounds in a mouse model with schizophrenia-like phenotypes. Marta di Forti group will use blood samples from our groups to test epigenetic changes comparing control and mutant model groups and compare these findings with control and schizophrenia patients that intake cannabis. |
Collaborator Contribution | Our partner, Marta di Forti, in addition will test how the combination of THC and CBD together can influence behaviour and whether these modified the epigenetic profile. Marta has been recently awarded with an MRC SCF to begin this collaboration. |
Impact | The outcomes of this collaboration will be to identify genetic profiles that can lead to changes is signalling pathways driven by the intake of cannabis that can help to understand why cannabis increases the probability of psicosis in a likely borderline genetic background. These data will help to stratify patients and to identify potential targets for intervention. |
Start Year | 2019 |
Description | Retinal Organoids |
Organisation | Technical University of Dresden |
Country | Germany |
Sector | Academic/University |
PI Contribution | The focus of this award is to establish this collaboration and the use of retinal organoids. Our contribution is the provision of candidate genes for validation in the in vitro system. |
Collaborator Contribution | Expertise in Retinal Organoids culture |
Impact | Award is to start on 1.April 2021 (delayed start due to Covid-19) |
Start Year | 2021 |
Description | Roche collaboration |
Organisation | F. Hoffmann-La Roche AG |
Country | Global |
Sector | Private |
PI Contribution | My group is testing a GABA compound provided by Roche in animal models of autism. |
Collaborator Contribution | Roche is providing a GABA compound to us. |
Impact | NA |
Start Year | 2021 |
Description | Rodent rsfMRI |
Organisation | Italian Institute of Technology (Istituto Italiano di Tecnologia IIT) |
Country | Italy |
Sector | Academic/University |
PI Contribution | Provided new GM mouse model for rsfMRI |
Collaborator Contribution | Performed rsfMRI on a new mouse model of ASD |
Impact | Suetterlin et al. (2018) Cereb Cortex, in press |
Start Year | 2017 |
Description | Role of NRXN1 in autism Spectrum Disorders |
Organisation | University of Cambridge |
Department | Autism Research Centre (ARC) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Intellectual input, training of staff, expertise in stem cell biology and synapse biology, access to novel materials. |
Collaborator Contribution | Intellectual input and access to novel materials. |
Impact | This work has lead to 1 publication, 1 manuscript under review and several manuscripts under preparation. |
Start Year | 2016 |
Description | Sensory perception, repetitive behaviour and aggression |
Organisation | University of Coimbra |
Country | Portugal |
Sector | Academic/University |
PI Contribution | In this translational project, we are working together to identify neural mechanisms/circuits underlying sensory processing difficulties, repetitive behaviours and aggression linked to the Nrxn1 genetic mutation, which is associated with autism. As an integral component of our collaboration, we co-supervise a PhD student. |
Collaborator Contribution | Collaborators from the University of Coimbra are contributing clinical data on autistic individuals who share the same Nrxn1 mutation as our mouse models. This data encompasses a range of clinical phenotypes including sensory processing, locomotion, aggression, and repetitive behaviors. |
Impact | NA |
Start Year | 2023 |
Description | Single cell transcriptomics in the developing brain |
Organisation | Yale University |
Country | United States |
Sector | Academic/University |
PI Contribution | We have established a collaboration with the laboratory of Prof Nenad Sestan at Yale University to perform single cell transcriptomic experiments and analyse interneuron diversity in the developing brain of rodents and primates, including humans. We provide expertise in the molecular characterisation of GABAergic interneurons in this collaboration. |
Collaborator Contribution | We have established a collaboration with the laboratory of Prof Nenad Sestan at Yale University to perform single cell transcriptomic experiments and analyse interneuron diversity in the developing brain of rodents and primates, including humans. They provide expertise in single cell transcriptomics in this collaboration. |
Impact | doi: 10.1126/science.aar6821 |
Start Year | 2015 |
Description | The Developing Human Connectome Project |
Organisation | University of Oxford |
Department | Oxford Centre for Functional MRI of the Brain (FMRIB) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New collaboration leading to EU Synergy Grant |
Collaborator Contribution | fMRI technology and adult connectome experience |
Impact | EU Synergy Grant (€14.9m) multidisciplinary |
Start Year | 2013 |
Description | The role of cerebellar inhibitory interneurons in neurodevelopmental disorders |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developed and analysed a mouse model for a new recessive disorder associated with cerebellar hypoplasia |
Collaborator Contribution | Human clinical genetics and expertise in hypothalamus development and function |
Impact | Whittaker, D.E., Oleari, R., Gregory, L.C., Le Quesne-Stabej, P., Williams, H.J., GOSgene, Torpiano, J.G., Formosa, N., Cachia, M.J., Field, D., Lettieri, A., Ocaka, L., Paganoni, A.J.J., Rajabali, S., Riegman, K.L., De Martini, L.B., Chaya, T., Robinson, I.C.A.F., Furukawa, T., Cariboni, A.*, Basson, M.A.* & Dattani, M.T.* (2021) A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia. J. Clin. Invest. 131:e141587. *Joint corresponding authors. https://www.jci.org/articles/view/141587 |
Start Year | 2018 |
Description | Translational research |
Organisation | The Hospital for Sick Children (SickKids) |
Country | Canada |
Sector | Hospitals |
PI Contribution | We are supplying preclinical data derived from a mouse model that harbors the same genetic mutation as patients at SickKids (Canada). Our aim is to decipher the mechanisms underlying clinical phenotypes, such as sensory difficulties, locomotor challenges, repetitive behaviors, and aggression. |
Collaborator Contribution | Our collaborator at SickKids is contributing clinical data obtained from autistic individuals with mutations in the Nrxn1 gene. |
Impact | NA |
Start Year | 2023 |
Description | Ultralow Field MR imaging for newborn infants |
Organisation | Bill and Melinda Gates Foundation |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | new imaging methods for portable low-cost MRI brain imaging |
Collaborator Contribution | provided a novel 64mT MR scanner |
Impact | New methods for imaging newborn brain development and pathology- portable low-cost MRI |
Start Year | 2019 |
Description | Validating biomarkers in animal and cellular models of autism |
Organisation | Karolinska Institute |
Country | Sweden |
Sector | Academic/University |
PI Contribution | Materials, intellectual input and expertise in developmental and circuit-based biomarkers in rodent models. |
Collaborator Contribution | Training of staff, access to novel materials and instruments, intellectual input. |
Impact | No outcomes yet. |
Start Year | 2017 |
Description | Validating biomarkers in animal and cellular models of autism |
Organisation | University of Basel |
Country | Switzerland |
Sector | Academic/University |
PI Contribution | Materials, intellectual input and expertise in developmental and circuit-based biomarkers in rodent models. |
Collaborator Contribution | Training of staff, access to novel materials and instruments, intellectual input. |
Impact | No outcomes yet. |
Start Year | 2017 |
Description | Validating biomarkers in animal and cellular models of autism |
Organisation | University of Groningen |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Materials, intellectual input and expertise in developmental and circuit-based biomarkers in rodent models. |
Collaborator Contribution | Training of staff, access to novel materials and instruments, intellectual input. |
Impact | No outcomes yet. |
Start Year | 2017 |
Description | Validating biomarkers in animal and cellular models of autism |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Materials, intellectual input and expertise in developmental and circuit-based biomarkers in rodent models. |
Collaborator Contribution | Training of staff, access to novel materials and instruments, intellectual input. |
Impact | No outcomes yet. |
Start Year | 2017 |
Description | Validating biomarkers in animal and cellular models of autism |
Organisation | University of Ulm |
Country | Germany |
Sector | Academic/University |
PI Contribution | Materials, intellectual input and expertise in developmental and circuit-based biomarkers in rodent models. |
Collaborator Contribution | Training of staff, access to novel materials and instruments, intellectual input. |
Impact | No outcomes yet. |
Start Year | 2017 |
Description | Wellcome/EPSRC Centre for Medical Engineering, awarded 2019 |
Organisation | King's College London |
Department | Division of Imaging Sciences and Biomedical Engineering |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Infrastructure funding for Medical Engineering, including the work from this grant |
Collaborator Contribution | Preliminary data for application; work theme within the Centre |
Impact | Collabrative work in progress |
Start Year | 2019 |
Description | iPSC neurons and microglia |
Organisation | Keio University |
Country | Japan |
Sector | Academic/University |
PI Contribution | Collaboration to develop and investigation iPSC derived from patients |
Collaborator Contribution | They are deriving the iPSC models and running experiments |
Impact | New materials |
Start Year | 2022 |
Description | multi-cell models of the human brain with optimised open-source protocols |
Organisation | Bit.Bio |
Country | United Kingdom |
Sector | Private |
PI Contribution | We are alpha and beta testing protocols from bit.bio and are developing optimised open-sourced protocols to be used with these products and similar research tools. My team is working directly with the cell products generated by bit.bio |
Collaborator Contribution | bit.bio are providing my team with access to newly developed cell products in a 'first-access' manner - that is, access before products are available to general users. We are also given opportunities to meet with other researchers and collaborative opportunities. |
Impact | None yet |
Start Year | 2023 |
Title | MRI SCANNER-COMPATIBLE VIRTUAL REALITY SYSTEM |
Description | Aspects and embodiments provide an MRI scanner-compatible virtual reality system comprising: user equipment locatable within an MRI scanner bore, the user equipment being configured to provide a subject with an immersive virtual environment; the system further comprising: at least one sensor configured to track eye movement of the subject; wherein interaction of the subject with the immersive virtual environment is controlled by the tracked eye movement. Aspects and embodiments may be implemented in a manner which recognises that VR techniques, which typically rely upon dynamic movement of a VR subject, can be used to aid with maintenance of minimal motion of a subject to be placed within an MRI scanner bore. Implementations may be such that calmness of a subject can be increased and awareness of their physical surroundings diminished, thus allowing for successful MRI image acquisition whilst seeking to minimise distress, boredom and/or frustration experienced by the subject under study. |
IP Reference | WO2020217068 |
Protection | Patent granted |
Year Protection Granted | 2020 |
Licensed | No |
Impact | Interest and discussion with Siemens. Concept has also been presented at the ISMRM conference. |
Title | Developing Mobile Digital Technologies to Measure Stress-Biomarker Signatures Across Psychotic Illness Stages |
Description | Developing Mobile Digital Technologies to Measure Stress-Biomarker Signatures Across Psychotic Illness Stages |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2021 |
Development Status | Under active development/distribution |
Impact | - |
Title | NeuroFind |
Description | Using Neurofind (AI deep-learning algorithm) to make individualised inferences in first episode psychosis: feasibility, acceptability and clinical utility in a real-world setting |
Type | Products with applications outside of medicine |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2021 |
Development Status | Under active development/distribution |
Impact | - |
URL | https://neurofind.ai/ |
Title | Remote Assessment of Disease and Relapse in Central Nervous System Disorders (RADAR-CNS) |
Description | A collaborative research programme exploring the potential of wearable devices to help prevent and treat depression, multiple sclerosis and epilepsy |
Type | Support Tool - For Medical Intervention |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2021 |
Development Status | Under active development/distribution |
Impact | - |
URL | https://www.radar-cns.org/ |
Title | Software for 'Unsupervised Human Pose Estimation through Transforming Shape Templates" |
Description | Human pose estimation is a major computer vision problem with applications ranging from augmented reality and video capture to surveillance and movement tracking. In the medical context, the latter may be an important biomarker for neurological impairments in infants. Whilst many methods exist, their application has been limited by the need for well annotated large datasets and the inability to generalize to humans of different shapes and body compositions, e.g. children and infants. In this paper we present a novel method for learning pose estimators for human adults and infants in an unsupervised fashion. We approach this as a learnable template matching problem facilitated by deep feature extractors. Human-interpretable landmarks are estimated by transforming a template consisting of predefined body parts that are characterized by 2D Gaussian distributions. Enforcing a connectivity prior guides our model to meaningful human shape representations. We demonstrate the effectiveness of our approach on two different datasets including adults and infants. |
Type Of Technology | Software |
Year Produced | 2021 |
Open Source License? | Yes |
Impact | Software was presented at the prestigious CVPR conference 2021 and has initiated a collboration with researchers at the Norwegian Technical University. |
URL | https://github.com/lschmidtke/shape_templates |
Title | continuous_cGAN |
Description | Builds generative models of cortical development and ageing from cortical imaging feature sets |
Type Of Technology | Software |
Year Produced | 2023 |
Open Source License? | Yes |
Impact | Paper under revision for Imaging Neuroscience |
URL | https://github.com/Abdulah-Fawaz/continuous_cGAN/blob/main/LICENSE |
Description | "Psyche" at the Science Gallery, Bengaluru, India |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | "Psyche" Scientific Advisor for the Psyche season at the Science Gallery, Bengaluru, India |
Year(s) Of Engagement Activity | 2021 |
URL | https://sciencegallery.org/opencall/psyche |
Description | 19th National Meeting of the Spanish Society of Neuroscience, symposium on Origin and expansion of the neocortex |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Invited speaker for the Origin and expansion of the neocortex symposium at the 19th National Meeting of the Spanish Society of Neuroscience. |
Year(s) Of Engagement Activity | 2021 |
Description | ARUK Donor Lab Tour - Olswang (Law Firm) Visit |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Demonstrations and examples of advanced microscopy for members of Olswang law firm. A guided tour of the microscopy suite was made to approximately 25-30 people with a short presentation explaining how these microscopes are used to help answer questions and contribute to understanding the pathophysiology of Alzheimer's Disease. Finally, a demonstration of fluorescent microscopy was presented. The principle purpose of the day was to highlight how the money raised through corporate contributions is used within a research environment; the tour was directed by Deepak Srivastava with the support of Iain Watson (ARUK funded PhD student). This session allowed to direct engagement with funders to inspire about the work being carried out from their contributions. Following the short tour, presentation and demonstration, Iain Watson then joined the group for lunch and a questions and answers session to address and further inquiries the visitors had. |
Year(s) Of Engagement Activity | 2017 |
Description | ARUK Open Day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | This visit involved representatives from ARUK, joined by contributors to the charity including key funders and donors, volunteers from both in and outside the organization as well as people working within dementia including carers. A total of approximately 60-70 people attending representing a wide variety of ages and abilities. The visitors were again given a guided tour of the microscope facilities, with a short presentation and examples of microscopy images taken from each of the microscopes. The purpose of the day was to engage with all sections of charity and highlight the research contributions at one of ARUK's Network Centre. Iain Watson (ARUK funded student) and Deepak Srivastava made themselves available for a question and answer session following the microscopy tour. |
Year(s) Of Engagement Activity | 2017 |
Description | Anatomy Explorers |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | International partnership outreach Project conducted to stimulate interest in anatomy |
Year(s) Of Engagement Activity | 2020 |
Description | BBC Radio interview about the future of diagnosis and treatment for autism spectrum disorders |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | On 26th July 2019, an episode of D for Diagnosis aired on BBC Radio 4 about the ever-changing labels for diagnoses in psychiatric and neurodevelopmental disorders. MRC CNDD group leaders, Declan Murphy and Grainne McAlonan, were featured and interviewed in the episode about current research in autism spectrum disorders and how they envisage the future. The airing of the programme resulted in many queries and enquiries from across the country about potential therapies for autism from people who w |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.bbc.co.uk/sounds/play/m0007126 |
Description | BlackBrainSci Showcase |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Outreach event (online workshop) in partnership with Women of the Wohl for Black History Month |
Year(s) Of Engagement Activity | 2020 |
Description | Brain demonstration for the BRC Adolescent Advisory Group |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | General introduction to neuroanatomical terms, structure and function of the human brain and a practical making a brain out of modelling clay. |
Year(s) Of Engagement Activity | 2019 |
Description | BrainFacts Live! "Journey to the inner cosmos" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | BrainFacts Live! "Journey to the inner cosmos" pint-of-science style evening talks and music. Washington DC |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.brainfacts.org/for-educators/programs-and-events/three-neuroscientists-walk-into-a-bar-r... |
Description | Brainwaves at the Sidmouth Science Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Science Festival outreach activity involving Sidmouth Primary Schools and Pint of Science events in partnership with Exeter University |
Year(s) Of Engagement Activity | 2017,2018,2019,2022 |
URL | https://www.sidmouthsciencefestival.org/ |
Description | Bristol Brain Awareness Week |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The Brain Awareness Week (BAW) is a worldwide initiative dedicated to enhancing public awareness of the progress and benefits of brain research. One of these activities, is to establish a network of researchers and professionals to exchange ideas and discuss concerns but also work to close the gap between science and the general public. With this in mind, the 2024 BAW event is under the slogan of "Feeding Connections: Bringing the Brain of Tomorrow." |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.fens.org/engagement/outreach/baw |
Description | CDN DNA Champions visit |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | DNA Champions is the follow-on programme of interactions designed specially for our DNA Summer School participants. The Y13 DNA Champions will be moving around the department between 11:00-13:00 and partaking in lab tours and some short sessions with researchers exploring the lab and the research questions. |
Year(s) Of Engagement Activity | 2021 |
URL | https://kings.padlet.org/leighwilson/e5gnn6qik6igoiht |
Description | CHARGE family support group |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presented our findings on cerebellar hypoplasia and ongoing research in brain abnormalities associated with CHARGE syndrome to the UK CHARGE family support group. Between 50-100 people were present consisting of professional practitioners (Clinical genetics, Psychiatry, deaf-blind teachers), carers, parents and patients. This activity raised awareness amongst the community for cerebellar and brain abnormalities in CHARGE and how investigating these may contribute to our understanding of a range of neurodevelopmental, psychiatric, behavioural ands learning issues associated with CHARGE syndrome. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.eventbrite.co.uk/e/charge-syndrome-uk-conference-professionals-day-registration-46510535... |
Description | Cell Voices: Building a Better Brain |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Opinion piece in Cell about the future of neuroscience and the possibility of building new or enhancing our own brains. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.cell.com/cell/fulltext/S0092-8674(18)31318-7?_returnURL=https%3A%2F%2Flinkinghub.elsevie... |
Description | Climbing the academic ladder |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Undergraduate students |
Results and Impact | Workshop with a panel participating in talks and debate with the topic Career in Science, women in Science |
Year(s) Of Engagement Activity | 2020 |
Description | Consultant for the Science Media Centre |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Consultant for the Science Media Centre which are an independent press office helping to ensure that the public have access to the best scientific evidence and expertise through the news media when science hits the headlines. In this role, I review articles highlighted by the press and comment on the interpretation and impact of the research, advising the media on how to present the research. |
Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020,2021,2022,2023,2024 |
URL | https://www.sciencemediacentre.org/ |
Description | Corpal - Agensis of the Corpus Callosum family event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Invited presentation to the Corpal charity for Agenesis of the Corpus Callosuum awareness day. Gave an online lecture to members of the public and patient families. |
Year(s) Of Engagement Activity | 2021 |
Description | Cossy Science, Brain Development |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | It was a public talk about Neuroscience at the pub for general public |
Year(s) Of Engagement Activity | 2018 |
Description | DevNeuro Academy |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | DevNeuro Academy: Flagship annual public engagement summer school. Held online in 2021 due to Covid (but consequently we were able to take more students than previously). |
Year(s) Of Engagement Activity | 2021,2022,2023 |
URL | https://kings.padlet.org/leighwilson/3ndfcny014xb5dwm |
Description | DevNeuro Academy |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | I have also recently joined the public engagement committee for the MRC Centre for Neurodevelopmental Disorders (CNDD), which includes the organisation of the DevNeuro Academy. The DevNeuro academy which is a widening participation project to improve progression and success of school students from under-represented backgrounds, who have a particular interest in understanding Neuroscience. It includes specific events across the year and a week long programme of activities in the Summer which provides exposure and teaching about different aspects of Neuroscience and research. |
Year(s) Of Engagement Activity | 2021,2022,2023 |
URL | https://devneuro.org/cdn/public-engagement-dna.ph |
Description | DevNeuro Academy |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | The DevNeuro Academy Widening Participation project consists of a regular programme of activities designed to improve the progression and success of students currently under-represented at our university and other institutes of higher education. The project combines a series of four in-school interactive 'Discovery workshops' with a two-week laboratory summer research work experience in our Centre. At the end of the work experience there will be a graduation ceremony here at Guy's campus. The students' families, class-mates and teachers will be invited and the students will be presented with a certificate. |
Year(s) Of Engagement Activity | 2021,2022,2023,2024 |
URL | https://devneuro.org/cdn/public-engagement-dna.php |
Description | DevNeuro Academy |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | The DevNeuro Academy Widening Participation project consists of a regular programme of activities designed to improve the progression and success of students currently under-represented at our university and other institutes of higher education. The project combines a series of four in-school interactive 'Discovery workshops' with a two-week laboratory summer research work experience in our Centre. At the end of the work experience there will be a graduation ceremony here at Guy's campus. The students' families, class-mates and teachers will be invited and the students will be presented with a certificate. Students from non-selective state schools are widely under-represented at top universities. 48% of privately educated children go on to study at a highly selective university, whilst only 18% of state school children, and a staggering 2% of children eligible for free school meals, gain a place at a highly selective university. The primary objective of the DevNeuro Academy project is to engage with local non-selective state schools and contribute towards changing these numbers. The workshops were designed with the goal of providing the students with solid conceptual foundations, as well as skills and new ideas to further build on. Each workshop combines theoretical talks and lots of interactive activities about the exciting field of developmental neurobiology. |
Year(s) Of Engagement Activity | 2016,2017,2018,2019,2020 |
Description | DevNeuro Champions |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | A spin-off from DevNeuro Academy - DevNeuro Champions - was launched to offer in-person Campus visits and lab workshops to those in DevNeuro Academy 2021. As well as lab experience, the Champions have also been receiving careers and university applications advice from Centre members. |
Year(s) Of Engagement Activity | 2021,2022,2023 |
Description | DevNeuroAcademy mentor |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | A postdoctoral researcher member of my Team, Frederike Winkel, participated in this activity. The DevNeuroAcademy Widening Participation Program includes a series of interactive discovery workshops aiming to improve the progression and success of students currently underrepresented at our university. The mentoring role involves supporting and helping the students in the preparation of a mini-project as well as hosting them during a lab visit. |
Year(s) Of Engagement Activity | 2021 |
Description | Developmental Medicine and Child Neurology Video Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Developmental Medicine and Child Neurology blog on Youtube - Down sydnrome: new approaches to studying early brain development |
Year(s) Of Engagement Activity | 2019 |
Description | Developmental Neurobiology Academy - a widening participation summer school for London Year 12 students |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Dev Neuro Academy: A week-long programme of interactions culminating in a piece of science communication about a neuro research topic. Each year DNA invites 55 Year 12 A-level (16/17 yr old) students from 21 different London Borough Schools focusing on partnership with schools embedded in communities with high proportions of underrepresented groups. The emphasis of the Academy is 'connection' and peer-peer network development and support. |
Year(s) Of Engagement Activity | 2021,2022,2023,2024 |
URL | https://www.kcl.ac.uk/developmental-neurobiology-academy-exploring-neuroscience-creating-opportuniti... |
Description | EMBO Practical Course, Developmental neurobiology: From stem cells to circuits |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Co-organiser for the 2 week EMBO practical course, organising lab sessions, speakers, poster sessions and discussions. |
Year(s) Of Engagement Activity | 2023 |
URL | https://meetings.embo.org/event/21-dev-neurobiology |
Description | EMBO practical course Developmental neurobiology: From worms to mammals |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | My group including BBSRC funded student and a postdoc has been participating in the EMBO practical course where students and young postdocs were introduced widely used techniques, in utero electroporation. In the course, we introduced our work supported by the BBSRC as an example how the technique provides versatile tools to elucidate the gene function in the developing nervous system. |
Year(s) Of Engagement Activity | 2015,2017,2019 |
URL | https://devneuro.org/cdn/courses.php |
Description | EMBO practical course Developmental neurobiology |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | We have provided a practical courses of mouse in utero surgery to EMBO participants. |
Year(s) Of Engagement Activity | 2015,2017,2019,2023 |
Description | Evidence provided to the EU Parliament on the effect of cannabis on mental health and the need for intervention |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | I was ask to provide evidence and contribute to an official document presented by the Onorevole Danzi at the EU Permanent at the end of the 2023. The document reviewed the evidence on the impact of cannabis use on Mental Health in young adults and the need for public education and for treatment services for those who develop dependence |
Year(s) Of Engagement Activity | 2023,2024 |
Description | FlyLab |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | FlyLab is an initiative to engage secondary school children in planning, designing and executing scientific experiements with model organisms and then analysing and interpreting the data. The project is long-standing and run in collaboration with a school in Kent. |
Year(s) Of Engagement Activity | 2017,2018,2019 |
Description | Frontiers in Science talk: How does the human brain develop? The role of size and shape. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | I gave a frontiers in science talk to science educators at the Annual Conference of the Association of Science Education. |
Year(s) Of Engagement Activity | 2024 |
URL | https://2024aseannualconference.sched.com/event/1O497/frontier-science-how-does-the-human-brain-deve... |
Description | Gender narrative in leadership |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | This was an opinion piece published in the Times Higher Education, highlighting the issues around the narrative that - tells us that to correct the gender imbalance in leadership we have to 'fix weaknesses' in women or masculinise their behaviour. - promote the male style and priorities in leadership as the perfect model (absence of critical revision of male leadership) It was very well received and acquire a lot of visibility through Twitter feeds and readers feedback. It let to actions taken at University levels and conversations with funding agencies such as the Wellcome Trust. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.timeshighereducation.com/opinion/leadership-qualities-do-not-have-gender |
Description | Green Man Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Stall hosted at Green Man Festival in Einstein's Garden with aim to engage general public in neurobiology and neurodevelopmental disorders. The stall has attracted approximately 500 visitors per year. |
Year(s) Of Engagement Activity | 2018,2019,2021 |
Description | Hidden Figures |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | Career in Science, women in Science Guest speaker in the course called Hidden Figures at Virginia University. The course introduces students to the basic concepts in neuroscience while highlighting contributions from women and other groups historically excluded from STEM. Each week features a guest scientists whose work is related to the concepts taught that week. Students generate Wikipedia entries for the guest speakers as a part of their final assignment, aiming to increase the proportion of Wikipedia entries for women in STEM. In addition, Lectures are transcribed by students in form of an interview and posted on a collaborative arts and sciences blog: https://www.conjugate.blog/ |
Year(s) Of Engagement Activity | 2021 |
URL | https://en.wikipedia.org/wiki/Beatriz_Rico_(neuroscientist) |
Description | Hindges Lab Twitter account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | The account reports on research findings and activities from our lab. The account has about 1000 followers |
Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020 |
URL | https://twitter.com/RobertHindges |
Description | In preprints: shaping the developing human brain |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | A short commentary on the preprint Jain, A., Gut, G., Sanchis-Calleja, F., Okamoto, R., Streib, S., He, Z., Zenk, F., Santel, M., Seimiya, M., Holtackers, R. et al. (2023). Morphodynamics of human early brain organoid development. bioRxiv. https://doi.org/10.1101/2023.08.21.553827, including a summary of the findings and how this compares to other papers in the field. |
Year(s) Of Engagement Activity | 2023 |
URL | https://journals.biologists.com/dev/article/150/24/dev202567/336561/In-preprints-shaping-the-develop... |
Description | In2Science placements |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | in2scienceUK is a charity which empowers students from disadvantaged backgrounds to achieve their potential and progress to STEM and research careers through high quality work placements and careers guidance. The MRC Centre for Neurodevelopmental Disorders works with the charity and offers several month-long or longer placements to students. We have found that students on these placements gain in confidence and motivation. |
Year(s) Of Engagement Activity | 2017,2018,2019 |
Description | In2science UK programme |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | In2science is a programme designed to boost diversity and inclusion in STEM for school children from disadvantaged backgrounds. I acted as mentor for 3 school children interested in a career in medicine and science, and hosted two mentorship sessions and a visit to my department to give them exposure to a science/hospital environment. |
Year(s) Of Engagement Activity | 2021 |
URL | https://in2scienceuk.org/ |
Description | Interview about Brexit for Science |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Interview with Science about the potential impact of Brexit on science in the UK |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.sciencemag.org/news/2018/12/looming-parliament-vote-boosts-brexit-jitters-uk-scientists |
Description | Interview and KCL blog post "In Conversation with Dr Tomoki Arichi" |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Interview and blog post about ultra-high field imaging, recent attainment of funding, and current research |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.kcl.ac.uk/news/in-conversation-with-dr-tomoki-arichi |
Description | Interview for New Scientist article on our paper, Massimo et al 2023. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | I was interview by the journalist Michael Marshall for the following article https://www.newscientist.com/article/2376051-does-covid-19-affect-pregnancies-and-do-the-vaccines-reduce-any-risks/ |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.newscientist.com/article/2376051-does-covid-19-affect-pregnancies-and-do-the-vaccines-re... |
Description | Interview on BBC Horizon "Cannabis: Miracle medicine or dangerous drug?" |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | On 28 August 2019, the BBC Horizon episode "Cannabis: Miracle medicine or dangerous drug aired". The TV programme reported on the latest medical and scientific research into the effects of cannabis on the brain and body. King's College London featured heavily in the programme and Philip McGuire, MRC CNDD group leader, gave an interview on the programme about the potential of cannabinoid cannabidiol as a novel therapeutic agent for psychosis and those at very high risk for psychosis. The interview Prof McGuire gave resulted in many contacts from people across the country with questions about cannabidiol and questions about participating in research studies. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.bbc.co.uk/programmes/m0007zly |
Description | Invited member of the London Meyor Drug Commission |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | The London Drug Commission as been set up to review the local and international evidence on cannabis use health, crime and different aspect of society to inform of possible policy changes in London and UK The work of the commission lead by Lord falconer is ongoing |
Year(s) Of Engagement Activity | 2023,2024 |
URL | https://www.london.gov.uk/programmes-strategies/mayors-office-policing-and-crime-mopac/mopac-governa... |
Description | Invited seminar presentaiton, Centre for the Developing Brain, KCL |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I gave a seminar on our MRC-funded work concerning the impact of maternal immune activation on rodent brain development, as part of the local seminar series. |
Year(s) Of Engagement Activity | 2019 |
Description | Invited seminar presentation, University of Swansea |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I gave an invited seminar to the Neuroscience group at the University of Swansea, School of Medicine on the use of small animal MRI in neuroscience research. This sparked interest in this technology and will hopefully lead to future collaborations. |
Year(s) Of Engagement Activity | 2019 |
Description | Invited seminar speaker, Mouse Brain Imaging Centre, University of Toronto |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I was invited to give a talk on my research funded by this award at the Mouse Brain Imaging Centre at the University of Toronto. This has led to the development of new collaborations and data that will be submitted for publication in due course. |
Year(s) Of Engagement Activity | 2017 |
Description | Invited seminar to the Neuroscience society at Trinity College, Dublin (Ireland) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Approximately ~30 people from the Trinity Institute of Neuroscience attended a Trinity Neuroscience seminar given by myself, which including a description of my research into the effects of antipsychotic drugs on brain volume and the interactions with the immune system, as well as work on maternal immune activation models, funded by the MRC. The session provoked a lenthgy series of questions and there were several independent meetings with principle investigators in the School thereafter to discuss possible future and ongoing research collaborations. |
Year(s) Of Engagement Activity | 2016 |
Description | Invited speaker at symposium on Bringing structural biology to cells and tissues |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other audiences |
Results and Impact | A symposium was organised at King's College London to explore the wider use of EM in revealing the organisation and molecular details of subcellular compartments within cells. Following my talk I discussed possible collaborations with both the speakers and scientists in the audience. |
Year(s) Of Engagement Activity | 2022 |
Description | Invited speaker at the joint Oxford-Cambridge-KCL BNA Symposium on EI balance |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | PhD students from Oxford, Cambridge and KCL organised a symposium to discuss EI balance - it sparked discussions on the topic and led to possible collaborations with people in the audience |
Year(s) Of Engagement Activity | 2022 |
Description | Invited speaker, Charité - Universitätsmedizin Berlin |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | I gave a research seminar at the Institut für Medizinische Psychologie to the groups led by Professors Buss and Etringer around the work conducted in my lab on maternal immune activation (funded by MRC) in which we have a mutual research interest with potential for translation to human work from our animal studies and vice versa. The talk sparked some debate and plans for future activity were discussed. |
Year(s) Of Engagement Activity | 2018 |
Description | Invited speaker, Heinrich Heine University Düsseldorf |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | I gave the guest lecture at the 2018 iBrain graduate school symposium at Heinrich Heine University Düsseldorf. This sparked questions from the students about our work and allowed me to interact with other faculty at HHU, including my existing collaborators there. |
Year(s) Of Engagement Activity | 2018 |
Description | Invited speaker: King's College London BRAIN centre open day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | The department of Neuroimaging, King's College London organised an open day to celebrate the commissioning of the new BRAIN centre at KCL, which houses a state-of-the-art Bruker BioSpec 9.4T animal MRI scanner, which I utilise in the research conducted in my laboratory funded by this grant. As such, I was invited to present some of my work to the invtied attendees. |
Year(s) Of Engagement Activity | 2017 |
Description | K+ student engagement activity |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Engagement activity for students in the K+ program as a workshop held at the Science Gallery London. The activity brought together information about "vision", the "eye" and "how we process visual information", paired with an activity facilitated through an artist on the issue of how we recognise and draw/paint faces. |
Year(s) Of Engagement Activity | 2019 |
Description | Keynote speaker for UMC Utrecht PhD Course on Neurodevelopment |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Invited keynote speaker for the UMC Utrecht PhD Course on Neurodevelopment. |
Year(s) Of Engagement Activity | 2021 |
Description | Lecture about accessing HE and applying to university |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | In May 2019, the MRC CNDD hosted a lecture for students from local 6th forms about how and why to apply to do medicine and sciences at university. Attendees reported more motivation to apply to high-ranking universities and better clarity about what to include and what not to include in their UCAS forms. |
Year(s) Of Engagement Activity | 2019 |
Description | Level Up Human Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Live recording with audience participation of a Podcast Series "Level Up Human" at the Barbican to discuss possible ways to "enhance" the human (science/comedy). Podcast is now available to general public. |
Year(s) Of Engagement Activity | 2019 |
Description | Living Well with Medi-Culture: Memory |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | This was a live audience Q&A interview about our work. |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.mediculture.co.uk/whats-on/living-well-with-medi-culturememory |
Description | MRC CNDD Instagram account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | MRC CNDD Instagram account created and used |
Year(s) Of Engagement Activity | 2019,2020,2021 |
Description | MRC CNDD newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Monthly MRC CNDD newsletter |
Year(s) Of Engagement Activity | 2017,2018,2019,2020 |
Description | MRC CNDD seminar series |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | MRC CNDD seminar series open to all at KCL |
Year(s) Of Engagement Activity | 2017,2018 |
Description | MRC CNDD website |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Dedicated, standalone website for the MRC Centre for Neurodevelopmental Disorders |
Year(s) Of Engagement Activity | 2017,2018,2019 |
URL | https://devneuro.org/cndd/index.php |
Description | MSc student lab tours |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Tours of the labs for postgraduate students from the University of Suffolk studying various biomedical degree programmes. |
Year(s) Of Engagement Activity | 2016,2017,2018,2019 |
Description | Making Emotions |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Artist in residence, Izzy Parker and Gemma Modinos: Community online project |
Year(s) Of Engagement Activity | 2020 |
Description | Marin lab twitter account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | The Marin lab twitter account reports our research findings since 2012. The account has over 3500 followers. |
Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017,2018,2019,2020,2021 |
URL | http://twitter.com/Marinlab |
Description | MarÃn lab website |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Marín lab website |
Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014,2015,2016,2017,2018,2019 |
URL | http://devneuro.org.uk/marinlab/default.aspx |
Description | Member of the MRC Centre for Neurodevelopmental Disorders (CNDD) Public Engagement Committee |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Member of the MRC Centre for Neurodevelopmental Disorders (CNDD) Public Engagement Committee - current campaigns include raising awareness of CNDD research via Instagram |
Year(s) Of Engagement Activity | 2021,2022,2023,2024 |
Description | Mentoring female refugee with interest in science career, partnering with the Charity Routes Collective. |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | I have been paired with a mentee who has been granted asylum in the UK and would like to pursue a career in science. |
Year(s) Of Engagement Activity | 2022,2023 |
URL | https://routescollective.com/mentoring |
Description | NeuroAgenda |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | NeuroAgenda is a social media initiative to promote equality for women in neuroscience. Women in neuroscience are interviewed and a new video is posted on Youtube each day for 12 days leading up to International Women's Day 2021. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=bTAtqbESEjw |
Description | NeuroAgenda was an initiative to celebrate and explore the journeys of the female scientists, educators, support and professional service members that contribute to the research at CDN and the MRC Centre for Neurodevelopmental Disorders. |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | NeuroAgenda was an initiative to celebrate and explore the journeys of the female scientists, educators, support and professional service members that contribute to the research at CDN and the MRC Centre for Neurodevelopmental Disorders. As part of International Women's Day celebration, it was both a celebration of female contribution to neuroscience and a mean of raising awareness of the ongoing need for gender parity in science research, particularly at senior levels. The aim is to inspire interest in STEM careers by providing insight into the pathways that the NeuroAgenda champions have encountered in their careers. Short profile posts included details of the professional journeys (education, roles, experience) as well as any challenges and hopes. I was interviewed by my MRC-PhD student Sara Ratti, a member of my team, that was the person that was running the engagement activity |
Year(s) Of Engagement Activity | 2021 |
Description | NeuroAnatomy Explorers |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Schools outreach project/roadshow to get primary school children interested in neuroanatomy |
Year(s) Of Engagement Activity | 2020 |
Description | Neuroscience Work Experience Week |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | I organized and ran a week long work experience for A-level school children from different schools across the South-East of the UK (predominantly London), including extensive practical laboratory experience. We plan to run this as a recurring event. |
Year(s) Of Engagement Activity | 2019 |
Description | Online webcasts in collaboration with BrainFacts.Org & NogginNW |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Online webcasts in collaboration with BrainFacts.Org & NogginNW: "Show us your Neuron" and "Research, Education and Outreach" |
Year(s) Of Engagement Activity | 2020 |
URL | http://brainfacts.org |
Description | Panel at MRC CNDD and Crick Symposium: Exploring the dimensions of research into the developing human brain |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Member of panel discussing three different views of this emerging landscape for exploring human brain development - how it speaks to those affected by conditions, the process of donation and how human developmental brain research can connect with a broader public audience |
Year(s) Of Engagement Activity | 2023 |
Description | Parent Power family engagement event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | I took part in a "Parent Power" event for families from Lambeth and Southwark organised by King's College London. This event was designed to provide a forum for families from the local community to hear about research and to be able to engage with researchers to ask questions. I spoke about my own work using MRI to study brain development and autism, and then had an open discussion and question/answer session with these families. |
Year(s) Of Engagement Activity | 2021 |
Description | Participation in an open day or visit at my research institution - CDN Dev Neuro Academy |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Co-hosted a workshop on fetal brain development for 50 sixth form students. |
Year(s) Of Engagement Activity | 2023 |
Description | Partnership with organisations supporting female asylum-seekers in London |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | We have formed a partnership with Routes Collective, a charity supporting female asylum-seekers in London, and Islington Centre for Migrants and Refugees to offer work experience placements, training, coaching and mentoring to women with an interest in and/or training in science. So far, one woman has been referred to us who has spent 3 months in different laboratories, gaining experience in different techniques and receiving mentoring on finding work in science. We have just heard that she has been offered a job in a hospital laboratory. |
Year(s) Of Engagement Activity | 2019,2020 |
Description | Perinatal Functional Imaging Twitter |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Twitter page (Kings_PFIG) to transmit current views, advertise positions, describe and disseminate current work. Currently 352 followers |
Year(s) Of Engagement Activity | 2018,2019,2020,2021 |
URL | https://twitter.com/Kings_PFIG |
Description | Perinatal Functional Imaging group website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Academic Group website, developed to provide information about the research work and provide access for resources such as data, analysis tools, and links to publications. The website is updated regularly to reflect current work and provide contract details. |
Year(s) Of Engagement Activity | 2018,2019,2020,2021 |
URL | http://www.perinatal-functional-imaging.co.uk |
Description | Pint of Science |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Public engagement in a Pub describing my research on learning and memory |
Year(s) Of Engagement Activity | 2019 |
URL | https://pintofscience.co.uk/event/our-play-doh-brains |
Description | Pint of Science talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | I gave a Pint of Science talk in May 2022: Shaping the developing human brain. |
Year(s) Of Engagement Activity | 2022 |
Description | Pint of Science talk to general public |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Pint of Science is a worldwide science festival which brings researchers to a local pub/cafe/space to share their scientific discoveries. I gave a talk entitled: 'A balancing act in the brain'. This was followed by a discussion and activities. |
Year(s) Of Engagement Activity | 2023 |
URL | https://pintofscience.co.uk/event/brain-development-hanging-in-the-balance |
Description | Podcast for Human Developmental Biology Initiative: Made the Same Way |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | I have taken part in a series of podcasts with HDBI researchers that brings together a researcher and musician. We discussed our research and music, resulting in the creation of a piece of music by the artist for the end of the podcast. |
Year(s) Of Engagement Activity | 2022,2023 |
URL | https://anchor.fm/made-the-same-way |
Description | Podcast on FOXG1 syndrome |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | On 20th February 2020, The Naked Scientists released a podcast "FOXG1 syndrome: fighting the odds" which featured MRC-Sackler PhD Fellow, Hannah Bruce talking about FOXG1, FOXG1 syndrome and her research. The podcast aired a week ago at the time of writing. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.thenakedscientists.com/podcasts/naked-genetics/foxg1-syndrome-fighting-odds |
Description | Podcast: "Molneux's problem": Blind Philosophy |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Podcast: "Molneux's problem" for BrainFacts.org |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.brainfacts.org/thinking-sensing-and-behaving/vision/2020/molyneuxs-problem-blind-philoso... |
Description | Presentation at Lifecourse MRI sponsored by Siemens (Dublin): Ultra-high field MRI of the neonate |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Siemens funded syposium about MRI across the lifespan - created discussion and new opportinuties for future collaboration |
Year(s) Of Engagement Activity | 2019,2024 |
Description | Presentation to 1,000 13-16 old school children in Rome, at La Sapienza University Deanary |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | I was invited, as international expert, to give a talk on the link between heavy cannabis use and psychosis to 1,000 school children from Rome secondary and high school as part of a program of Public Education run by the Roma La Sapienza, University |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.instagram.com/ass_valentina_de_castro/ |
Description | Presentation to A-level students at school |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | This was in part a careers talk about neuroscience, but also brought in aspects of 'learning how to learn', which is a new topic that I am working into my outreach and teaching. The idea is to take what we know about the biology of learning and memory and explain how that supports good educational and student practices at school and university. |
Year(s) Of Engagement Activity | 2022 |
Description | Promoting research in under-privileged schools |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | My lab is heavily participating to our Centre outreach programme selecting 30 A-level teenagers to receive seminars, workshop and lab placement across a few weeks in early summer. Schools targeted are from our underprivileged areas of South London. The event is covered by KCL web streams and Twitter feeds. |
Year(s) Of Engagement Activity | 2016,2017,2018,2019 |
URL | https://devneuro.org/cdn/public-engagement.php |
Description | Raising awareness on brain disorders |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | On Tuesday 9th May at 16:30, you will have the chance to watch the live streaming (by clicking here) of the conference 'Brain development: mental genius and illness' ('Desarrollo cerebral: genialidad y enfermedad mental') with Dr Óscar Marín, who completed his PhD in biology at the Complutense University in Madrid, and is the Head of the Centre for Developmental Neurobiology at the MRC in King's College London. He was the winner of the Banco Sabadell Award for Biomedical Research in 2008 and is currently a member of the jury. Dr Marín will explain how changes in the structure of the human brain could be the source of outstanding abilities and mental illnesses. Dr Óscar Marín won the third Banco Sabadell Award for Biomedical Research for his research in the field of neuroscience, which has been used in various projects focusing on the development of the brain and the anomalies that take place during this process, which have been shown to lead, on some occasions, to mental disorders such as autism and schizophrenia. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.fundacionbancosabadell.com/en/siguelo-en-streaming-desarrollo-cerebral-genialidad-y-enfe... |
Description | Rico lab website |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Rico lab website |
Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014,2015,2016,2017,2018,2019 |
URL | http://devneuro.org.uk/rico/default.aspx |
Description | School of Mental Health & Psychological Sciences (MHaPS) Research and Education Festival, Institute of Psychology and Psychiatry, King's College London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | I was invited as one of the speakers at the first Research and Education Festival of the School of Mental Health & Psychological Sciences, Institute of Psychology and Psychiatry, King's College London which sparked questions and discussion at the 'Meet the presenter' session, as well as attracted collaborations in epigenetics and mental health research. |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.kcl.ac.uk/showcasing-cutting-edge-research-and-educational-success-at-inaugural-mhaps-fe... |
Description | Seminar at Fundación Querer (Madrid, Spain) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | I discussed critical periods in brain development with an audience of about 250 people (in person and online) and answered questions about neurodevelopmental disorders. |
Year(s) Of Engagement Activity | 2022 |
Description | Seminar at Imperial College London and online on World Wide Neuro |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Around 40 postgraduate students, postdocs and scientists attended the seminar in person. The seminar was also held on online via the World Wide Neuro site. My talk sparked long discussions on the topic. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.world-wide.org/seminar/8320/ |
Description | Seminar at Sant Joan de Deu Children's Hospital (Barcelona, Spain) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | I discussed critical periods in brain development with an audience of about 250 people (in person and on line) and answered questions about neurodevelopmental disorders. |
Year(s) Of Engagement Activity | 2021 |
Description | Siemens Ultra-High field MRI Workshop in Poitiers France |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation about ultra-high field MR imaging of neonates at a workshop event hosted in Poitiers Hospital, France |
Year(s) Of Engagement Activity | 2024 |
Description | Sunnydown Synaptic: Journeys, Emotions + Brainstorms |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | An MRC-PhD student Sara Ratti, a member of my team, has been involved in this activity. The project captures the unique perspectives and experiences of students with communication and interaction needs associated with Autism Spectrum Disorder, through their own exploration of brain anatomy, cell connections and circuitry using sculpture, movement, collage, robotics and lasers. Designed to forge valuable exchanges between science, art, engineering and young students we hope that the project highlights the relevance of creative engagement and its importance in understanding and refining the stories that explain and clarify research into Autistic Spectrum Disorder as well as provide a compelling and effective vehicle for students to express opinions, feelings and reflections about their own experiences and current research into brain development and neurodiversity. In partnership with Team London Bridge & the Mediculture Festival, the project has culminated in an installation at the Old Operating Theatre (London Bridge), created by artist Charlie Murphy from upcycled lab glassware and student programmed lasers, lodged dramatically in the rafters of the Herb Garret museum. Still ongoing until the 9th of April. |
Year(s) Of Engagement Activity | 2021,2022 |
Description | Symposium speaker, Canadian College of Neuropsychopharmacology |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Appoximately 150 people attended our symposium "Translational Neuroimaging in Neurodevelopmental disorders: From Animal Models to Clinical Populations and Back Again" at the annual meeting of the Canadian College for Neuropsychopharmacology", which sparked questions and discussion afterwards |
Year(s) Of Engagement Activity | 2019 |
Description | Symposium speaker: Dysfunctional neuro-immune system interactions in psychiatric disorders: new possibilities for enhanced therapies, International Behavioural Neuroscience Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | I participated in an invited symposium entitled "Dysfunctional neuro-immune system interactions in psychiatric disorders: new possibilities for enhanced therapies" at the International Behavioural Neuroscience Society meeting in Japan (2017), where I presented results from work funded by this award. More than 150 people attended the session, with an excellent Q&A session after the speaker slots. We were then invited to contribute an article to a special issue linked to the meeting to be published in Neuroscience and Biobehavioural Reviews (in progress). |
Year(s) Of Engagement Activity | 2017 |
Description | Symposium speaker: Microglia, neuroinflammation and psychiatric disease: biomarkers and therapeutic potential, British Neuroscience Association |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | More than 200 people attended this symposium at the British Neuroscience Association national meeting in Birmingham where I presented results from work funded by this award. The presentations sparked a lively debate amongst the audience and speakers. |
Year(s) Of Engagement Activity | 2017 |
Description | Talk at The Judd School |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | 30 pupils frpom the biology society at The Judd school invited me to give a talk on my work. It sparked quesitons and discussions on neuroscience, how our brains form and neurodevelopmental disorders. |
Year(s) Of Engagement Activity | 2021 |
Description | Talk given at the Dev Neuro Academy |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | 50 pupils attended an online lecture as part of the Dev Neuro Academy organised by the Centre for Developmental Neurobiology at King's College London. It sparked questions on how neurons work and encode information, as well as the targets of different drugs and their effects on the brain. |
Year(s) Of Engagement Activity | 2021 |
Description | Times Radio interview with Hugo Rifkind |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Times Radio interview with Hugo Rifkind (20/5/23) in the publication of the "The Story of the Brain in 101/2 Cells" by Richard Wingate |
Year(s) Of Engagement Activity | 2023 |
Description | Twitter account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The MRC CNDD has an active Twitter account with 530 followers (at the time of writing). |
Year(s) Of Engagement Activity | 2018,2019,2020 |
URL | https://twitter.com/mrc_cndd?lang=en |
Description | UCL Neuroscience Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Panel discussion about the future of neuroscience |
Year(s) Of Engagement Activity | 2019 |
Description | Video abstract for paper Massimo et al, 2023 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | We made a video abstract for our recent paper that has been released on the journal's youtube page. https://www.youtube.com/watch?v=QJUJAI7qO3Q&ab_channel=BRAINJournals |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.youtube.com/watch?v=QJUJAI7qO3Q&ab_channel=BRAINJournals |
Description | Visit to London School |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | I visited a St.Bonaventure's School in Newham to deliver a talk on careers in neuroscience to GCSE and A-level students interested in pursuing a career in this sector. |
Year(s) Of Engagement Activity | 2019 |
Description | Webinar Action and Potential in Education |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Webinar Action and Potential in Education, Outreach and Research with Noggin NW. BrainFacts.org |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.brainfacts.org/for-educators/programs-and-events/action-and-potential-in-education-outre... |
Description | Webinar Reconnecting our Brain Cells, One Cell at a Time |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Webinar Reconnecting our Brain Cells, One Cell at a Time, with Noggin NW and Dr Leigh Wilson. BrainFacts.org |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.brainfacts.org/for-educators/programs-and-events/reconnecting-our-brains,-one-cell-at-a-... |
Description | William Little Foundation - evaluation of need for early intervention and recognition in cerebral palsy |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Inivited to participate in the working group and to review the draft document of an assessment and statement from the Willam Little Foundation about early recognition and intervention in cerebral palsy. |
Year(s) Of Engagement Activity | 2021 |
Description | Wingate lab website |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Wingate lab website |
Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017,2018,2019 |
URL | http://wingatelaboratory.blogspot.com |
Description | Women in Science |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Talk at the IBIS (Seville, Spain) with the topic of women in Science |
Year(s) Of Engagement Activity | 2022 |
Description | Women in Science |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Conducting a workshop in Aachen University (Germany) about women in Science |
Year(s) Of Engagement Activity | 2020 |
Description | Women in leadership |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Workshop aiming to educate wide public, students and professionals on the current obstacles preventing women to take senior leadership roles and giving the younger audience the tools, motivation and opportunities to progress to these posts and improve our leadership. My role is to provide a summary of my research achievements and identify what has enable me to reach a leadership position in my field. |
Year(s) Of Engagement Activity | 2018 |
Description | Work Experience Placements |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | The Hindges Lab has offered regularly Work Experience Placements for students from different schools (for example Pimlico Academy or Elmgreen School) to give them first hand experience in conducting biomedical research. We usually accepted 1-3 students per year. Feedback for participants was excellent and has changed their future plans to pursue a science degree. |
Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018 |
Description | Work experience week for A-level students at KCL |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | I contributed a single session on 'Mechanisms of Learning and Memory' to the King's College London Neuroscience Work Experience week for A-level students known as DevNeuro Academy. |
Year(s) Of Engagement Activity | 2021,2022 |
URL | https://devneuro.org/cdn/public-engagement-dna1.php |
Description | Workshop speaker: How can we refine pre-clinical psychopharmacology? British Association for Psychopharmacology |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | I was invited to participate in a pre-clinical workshop organised by the British Association for Psychopharmacology "How can we refine pre-clinical psychopharmacology?" to highlight the utility of pre-clinical neuroimaging in applied psychopharmacology research, including presentation of work funded by this award. The purpose of this session was primarily educational and there was a good take up from junior scientists (pre- and post-doctoral) keen to learn about new techniques for studying drug action in the brain. |
Year(s) Of Engagement Activity | 2017 |
Description | Young Persons Advisory Group Project |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Collaborative outreach work with the NIHR Biomedical Research Centre |
Year(s) Of Engagement Activity | 2020,2021 |
Description | in2ScienceUK |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | in2scienceUK is an award winning charity which empowers students from disadvantaged backgrounds to achieve their potential and progress to STEM and research careers through high quality work placements and careers guidance. Since 2014, the Hindges Lab has offered placements for one or two students per year to provide first hand experience on neuroscience, molecular biology and cell biology research to students. |
Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
Description | in2ScienceUK |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Placement of 2 students in my lab as part of the In2ScienceUK network. Subsequently I was asked to present my experience at the Gala evening to all students and parents, as well as other audiences. |
Year(s) Of Engagement Activity | 2018 |
Description | symposium on genetic generalised epilepsies |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | In June 2019, the MRC CNDD hosted a symposium about the latest research advances in genetic generalised epilepsies which was well-attended by patients and family members, several charities/patient groups as well as clinicians and researchers. |
Year(s) Of Engagement Activity | 2019 |
URL | https://twitter.com/hashtag/GGE2019?src=hashtag_click |
Description | work experience |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | 1- or 2-week work experience placements for approx. 10-20 students per year for students from local schools considering pursuing neuroscience/science subjects at university/KCL. In the placement, students spend time in the wet labs at the Centre for Developmental Neurobiology and spend time in the clinical research environment across several departments on the Denmark Hill Campus including Forensic and Neurodevelopmental Sciences, Psychosis Studies and Basic and Clinical Neuroscience. Students report finding the placements inspiring and useful in determining their subject and university selection for their UCAS applications. From 2020, these placements have also been adapted for online work experience. |
Year(s) Of Engagement Activity | 2016,2017,2018,2019,2020,2021 |