SENBIOTAR: Sensiting Pseudomonas aeruginosa biofilms to antibiotics and reducing virulence through novel target inhibition
Lead Research Organisation:
University of Nottingham
Department Name: School of Life Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The traditional approach to combating bacterial infections has been based on the use of antibiotics
which kill bacteria or inhibit their growth. There has also been a strong emphasis on the
identification of essential gene targets for drug intervention. A major problem with therapeutic
approaches targeting viability is that they induce strong selective pressures resulting in the rapid
emergence of antimicrobial resistance. An alternate approach is to inhibit virulence rather than
bacterial viability and this will be explored in the SENBIOTAR project. In the opportunistic human
pathogen Pseudomonas aeruginosa, virulence is co-ordinately controlled at the bacterial population
level through quorum sensing (QS), a global cell-to-cell communication system employing diffusible
signal molecules. P. aeruginosa strains with mutations in the Pseudomonas Quinolone Signal (PQS)
QS pathway are avirulent in experimental animal infections. The partners of this consortium will
exploit this information by optimising hit compounds and peptide nucleic acids (PNAs) they
identified previously which target PQS biosynthesis and/or PQS signal transduction. These hits have
been shown to not only render P. aeruginosa avirulent but also to sensitize biofilms to the action of
antibiotics. One of the limitations of using inhibitors of virulence is the fact that
immunocompromised patients may not be able to clear the targeted pathogen efficiently. However,
if the pathogen can, at the same time, be sensitised to antibiotics then there is great scope for dual
therapy with PQS inhibitors and antibiotics. SENBIOTAR will bring together world experts in QS,
medicinal chemistry, PNAs, drug delivery and preclinical studies to optimise the activity of the hit
compounds and PNAs (hit-to-lead optimization) with the intention of identifying lead compounds
which strongly inhibit QS, attenuate virulence and sensitise biofilms to conventional antibiotics at
sub-micromolar concentrations. This will be achieved by improving (a) their physicochemical
properties without the emergence of cytotoxicity, and (b) delivery to the site of infection. These
studies will be performed using a combination of in vitro virulence and biofilm bioassays alongside
experimental animal lung infection models. The lead compounds developed by SENBIOTAR will also
have significant potential for the treatment of wound, bloodstream and medical-device associated
infections caused by P. aeruginosa.
which kill bacteria or inhibit their growth. There has also been a strong emphasis on the
identification of essential gene targets for drug intervention. A major problem with therapeutic
approaches targeting viability is that they induce strong selective pressures resulting in the rapid
emergence of antimicrobial resistance. An alternate approach is to inhibit virulence rather than
bacterial viability and this will be explored in the SENBIOTAR project. In the opportunistic human
pathogen Pseudomonas aeruginosa, virulence is co-ordinately controlled at the bacterial population
level through quorum sensing (QS), a global cell-to-cell communication system employing diffusible
signal molecules. P. aeruginosa strains with mutations in the Pseudomonas Quinolone Signal (PQS)
QS pathway are avirulent in experimental animal infections. The partners of this consortium will
exploit this information by optimising hit compounds and peptide nucleic acids (PNAs) they
identified previously which target PQS biosynthesis and/or PQS signal transduction. These hits have
been shown to not only render P. aeruginosa avirulent but also to sensitize biofilms to the action of
antibiotics. One of the limitations of using inhibitors of virulence is the fact that
immunocompromised patients may not be able to clear the targeted pathogen efficiently. However,
if the pathogen can, at the same time, be sensitised to antibiotics then there is great scope for dual
therapy with PQS inhibitors and antibiotics. SENBIOTAR will bring together world experts in QS,
medicinal chemistry, PNAs, drug delivery and preclinical studies to optimise the activity of the hit
compounds and PNAs (hit-to-lead optimization) with the intention of identifying lead compounds
which strongly inhibit QS, attenuate virulence and sensitise biofilms to conventional antibiotics at
sub-micromolar concentrations. This will be achieved by improving (a) their physicochemical
properties without the emergence of cytotoxicity, and (b) delivery to the site of infection. These
studies will be performed using a combination of in vitro virulence and biofilm bioassays alongside
experimental animal lung infection models. The lead compounds developed by SENBIOTAR will also
have significant potential for the treatment of wound, bloodstream and medical-device associated
infections caused by P. aeruginosa.
Organisations
Publications
Grossman S
(2020)
Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
in European journal of medicinal chemistry
López-Lara IM
(2018)
2-Tridecanone impacts surface-associated bacterial behaviours and hinders plant-bacteria interactions.
in Environmental microbiology
Nguyen AT
(2016)
Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones.
in Frontiers in microbiology
Sou T
(2019)
Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection.
in Journal of pharmaceutical sciences
Soukarieh F
(2020)
Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa.
in Frontiers in chemistry
Soukarieh F
(2024)
Design, Synthesis, and Evaluation of New 1 H -Benzo[ d ]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections
in Journal of Medicinal Chemistry
Soukarieh F
(2018)
Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives.
in Journal of medicinal chemistry
Soukarieh F
(2023)
Design of Quorum Sensing Inhibitor-Polymer Conjugates to Penetrate Pseudomonas aeruginosa Biofilms
in ACS Macro Letters
Soukarieh F
(2018)
In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa.
in Molecules (Basel, Switzerland)
Soukarieh F
(2021)
Design and Evaluation of New Quinazolin-4(3 H )-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa
in ACS Infectious Diseases
Description | Strategic Research Centre: An evidence-based preclinical framework for the development of antimicrobial therapeutics in cystic fibrosis (PIPE-CF). |
Amount | £773,682 (GBP) |
Funding ID | SRC022 |
Organisation | Cystic Fibrosis Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 03/2026 |
Description | 42 SAIB Meeting joint with 16 SAMIGE Meeting, Argentina, November 2021 (on Line) TITLE: Complexity of quorum sensing regulatory systems and their therapeutic exploitation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | A mixed audience of academics, postgraduate and postdoctoral researchers and industrial partners attended this meeting. The idea was to disseminate the work we have been doing on the inhibition of bacterial quorum sensing signalling as a way to sensitise biofilms to antibiotics. The meeting also set some of the basis for an NBIC delegation visit to Argentina in 2022. |
Year(s) Of Engagement Activity | 2021 |
URL | http://congresos.g2consultora.com/congreso-conjunto-saib-samige-2021 |
Description | Antimicrobial Discovery and Biobanking Workshop - Accra (Ghana) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | This workshop brought together researchers and industry representatives from the UK and Ghana to establish a new partnership between the UK's National Biofilms Innovation Centre (NBIC), the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) and the Noguchi Memorial Institute for Medical Research (NMIMR) in Ghana to address biofilm-related challenges within areas of biobanking and antimicrobial discovery. The workshop enabled the understanding of the expertise, facilities, technologies, and capabilities available through each centre (NBIC, WACBIP and NMIMR) and scope out opportunities for future research collaborations. |
Year(s) Of Engagement Activity | 2023 |
Description | Business Engagement Oct-Dec 2021 Ceramysis and Upperton Pharmaceuticals |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Industry/Business |
Results and Impact | Monthly meetings with Ceramysis and Upperton to discuss progress from POC funded project and future avenues of collaboration. |
Year(s) Of Engagement Activity | 2022 |
Description | CONFERENCE PRESENTATION TITLE: Addressing the challenges with the interference of bacterial signalling in biofilms. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | This was a presentation given at Eurobiofilms 2019 in Glasgow. The session was on translational research and hence had a very mixed audience of academics, researchers, industrialist etc. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.biofilms.ac.uk/eurobiofilms-2019-nbic-highlights/ |
Description | CONFERENCE PRESENTATION TITLE: Microbiome and quorum sensing communications in skin health |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Presentation given at the SCS Formulate Conference 2019 in Coventry. There was a mixed audience mainly of companies working in skin care. A number of meetings took place during the day with different companies triggered by this presentation. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.scsformulate.co.uk |
Description | Conference participation (Central European Symposium on Antimicrobials and Antimicrobial Resistant (CESAR)) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Presentation of the data from SENBIOTAR at an antimicrobials conference in Croatia. There were around 120 participants form a wide range of academic and research institutions in Europe. There was a significant level of discussion amounts all participants around the data presented and this has resulted in the triggering of some discussions for future collaborative work. |
Year(s) Of Engagement Activity | 2018 |
URL | http://hmd-cms.hr/cesar2018/ |
Description | Early Discovery of New Antibiotics Workshop (Paris) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Third sector organisations |
Results and Impact | The purpose of this workshop was to share ideas on antibiotic development between upstream and developers by bringing the PIs in project areas of antibiotic early discovery and those in clinical development in order to identify potential candidates and increase awareness of entry requirements. It also promote increased awareness at early stage of entry requirements about future clinical developments and showcased early work on screening and identification of new targets. The title of the presentation given by Miguel Camara was: SENBIOTAR: Sensitising Pseudomonas aeruginosa biofilms to antibiotics and reducing virulence through novel target inhibition. |
Year(s) Of Engagement Activity | 2017 |
Description | FIP Pharmaceutical Sciences World Congress, Stockholm (Oral presentation) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Conference talk:- Sou T, Kukavica-Ibrulj I, Soukarieh F, Halliday N, Levesque RC, Williams P, et al. Quorum sensing inhibitors for pulmonary delivery as a novel treatment strategy against Pseudomonas aeruginosa. FIP Pharmaceutical Sciences World Congress, Stockholm, Sweden. 21st - 24th May 2017. The purpose was to promote the activities fo SENBIOTAR. |
Year(s) Of Engagement Activity | 2017 |
URL | http://pswc2017.fip.org/ |
Description | First Uganda National Conference on Antimicrobial Resistance |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Poster presentation of an MSc student who presented the research he carried out at Nottingham as part of the SENBIOTAR program. He represented to researchers in Uganda some of the highlights of this research program. The title of his poster was: Characterisation of inhibitors of the PqsR quorum sensing regulator in Pseudomonas aeruginosa. |
Year(s) Of Engagement Activity | 2016 |
Description | INTERNATIONAL SIMPOSIUM ON " GENE REGULATION IN BACTERIA WITH MEDICAL AND INDUSTRIAL INTEREST' Invited international speaker |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | The title of the invited talk was: 'Exploiting the therapeutic potential of targeting quorum sensing in Pseudomonas aeruginosa'. The symposium was organised by the Universidad Nacional Autonoma de Mexico in Mexico City. It was attended by master students, PhD students and research group leaders. |
Year(s) Of Engagement Activity | 2018 |
Description | International Seminar at the Universidad National Autonoma Mexico |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | This was a seminar to promote the results from the SENBIOTAR programme and identify new collaborations from the results of these programme as well as promote NBIC. The title of the seminar was: Versatility and targeting of quorum sensing signalling mechanisms There was a mixed audience of scientists |
Year(s) Of Engagement Activity | 2018 |
Description | International conference for pharmaceutical sciences ICPS 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Participation in the (International conference for pharmaceutical sciences ICPS 2021), and presenting a talk titled (SENBIOTAR: Sensitising Pseudomonas aeruginosa biofilms to antibiotics and reducing virulence through novel target inhibition ). The conference had over 150 participants from Academia and industry mainly from Middle east but also there were participation from USA, UK and Europe. |
Year(s) Of Engagement Activity | 2021 |
Description | Invited talk at symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Sou T, Kukavica-Ibrulj I, Soukarieh F, Halliday N, Levesque RC, Williams P, et al. Quorum sensing inhibitors for pulmonary delivery as a novel treatment against Pseudomonas aeruginosa. FIP Young Scientist Satellite Conference, Uppsala, Sweden. 19th - 21st May 2017. It help disseminating the work from SENBIOTAR amongst your researchers. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.scilifelab.se/events/8th-pharmaceutical-profiling-symposium/ |
Description | Invited talk- London Microbiome Meeting 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Hosted by the Department of Twin Research at King's College London and held twice a year, the London Microbiome Meeting aim to create a forum to share research that explores the field of microbiomics, providing a broad overview to both research and methodology. It aims to develop a microbiome research network between the various research groups and institutions across London and surrounding area undertaking this work. The title of the presentation was 'Targeting quorum sensing signalling as an antimicrobial strategy' and it has resulted in further engagement activities with a company that attended the meeting. |
Year(s) Of Engagement Activity | 2018 |
URL | http://londonmicrobiome.org/program.html |
Description | Key note Presentation at 17 SAMIGE Meeting in Argentina |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | This was an invited key note presentation at a the SAMIGE 17 conference. During the talk an overview of NBIC and some of the research activities taking place in in the Centre were highlighted with a particular emphasis on those taking place at Nottingham University. There was a discussion around the data presented from academics, postdoctoral researchers and PhD students. |
Year(s) Of Engagement Activity | 2022 |
URL | https://samige.org.ar |
Description | Oral presentation at the 5th UK Cystic Fibrosis Microbiology Consortium Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The activity was an oral presentation entitled: 'Targeting Pseudomonas aeruginosa virulence using novel inhibitors of the alkyl quinolone quorum sensing signalling pathway'. The idea was to inform academics, clinicians, postgraduates students and industry of the current work being carried out in the SENBIOTAR programme as an alternative approach to target Pseudomonas aeruginosa infections in the CF lung. |
Year(s) Of Engagement Activity | 2016 |
Description | Outreach talk at Singapore NTU University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | This workshop was organised by SCELCE in conjunction with the NTU and NUS Universities from Singapore to talk about biofilm research. The talk was joint and Miguel Camara spoke about the work achieved by SENBIOTAR. |
Year(s) Of Engagement Activity | 2018 |
Description | PRESENTATION TITLE: Complexity of the quorum sensing signalling systems and their exploitation as a therapeutic target. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | This was a research seminar at the University of Quilmes in Buenos Aires (Argentina). It was attended by a mixed audience including academics etc and the seminar recorded for a wider audience. Further discussions took place after the meeting which have resulted in new collaborations. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.youtube.com/watch?v=RmvJT8OnCYg&feature=youtu.be |
Description | Poster Presentation at the M4 Midland Molecular Microbiology Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other audiences |
Results and Impact | Symposium organise as a network activity for microbiology researchers in the Midlands including the Universities of Nottingham, Birmingham, Leicester and Warwick but there were also attendees from other Universities across the country. |
Year(s) Of Engagement Activity | 2016 |
Description | Poster at Pseudomonas 2017 international conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | SENBIOTAR: Sensiting Pseudomonas aeruginosa biofilms to antibiotics and reducing virulence through novel target inhibition Fadi Soukarieh, Tomas Sou, Mirko Iubatti, Eduard Vico, Irena Kukavica-Ibrulj, Nigel Halliday, Christel AS Bergström, Michael Stocks, Peter Nielsen, Paul Williams, Roger C. Levesque, Miguel Cámara - This poster introduced the main highlights of the SENBIOTAR programme. |
Year(s) Of Engagement Activity | 2017 |
URL | https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2017-16th-internat... |
Description | Poster presentation at international conference in Denmark |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | - Sou T, Kukavica-Ibrulj I, Soukarieh F, Halliday N, Levesque RC, Williams P, et al. Quorum sensing inhibitors for pulmonary delivery as a novel treatment against Pseudomonas aeruginosa. Northern Pharma Network Meeting, Odense, Denmark. 29th - 31st Jan 2018. (Best poster award) |
Year(s) Of Engagement Activity | 2018 |
URL | http://easp.ee/northern-pharma-network-meeting-2018-odense-denmark/ |
Description | Poster presentation at international conference in Liverpool |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Title: Pseudomonas aeruginosa PQS antagonist decreases virulence and increases biofilm sensitivity. Authors: Vico Oton E., Soukarieh F., Stocks M., Williams P., Heeb S., Cámara M. September 2017, Focused Meeting 2017: 16th International Conference on Pseudomonas. |
Year(s) Of Engagement Activity | 2017 |
URL | https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2017-16th-internat... |
Description | Poster presentation at international conference in San Diego |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | - Sou T, Kukavica-Ibrulj I, Soukarieh F, Halliday N, Levesque RC, Williams P, et al. A pharmacokinetic model of a new antimicrobial agent after pulmonary delivery for the treatment of chronic Pseudomonas aeruginosa lung infection. American Association of Pharmaceutical Scientists Annual Meeting, San Diego, USA. 12th - 15th Nov 2017. Presentation of results from the SENBIOTAR programme to an international audience |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.emedevents.com/c/medical-conferences-2017/american-association-of-pharmaceutical-scienti... |
Description | Postgraduate Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Study participants or study members |
Results and Impact | This was a training retreat for postgraduate students and the SENBIOTAR programme was introduced to them as part of a session entitled : 'Targeting virulence as an alternative approach to treat bacterial infections'. This was followed by a discussion with the students. |
Year(s) Of Engagement Activity | 2016 |
Description | Presentation at a national cystic fibrosis consortium meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Title: Sensitising Pseudomonas aeruginosa biofilms to antibiotics and reducing virulence through novel target inhibition. Authors: Fadi Soukarieh, Eduard Vico Oton, Jean Dubern, Nigel Halliday, Stephan Heeb, Michael Stocks, Paul Williams, and Miguel Cámara. 27/ November/ 2017 Cystic Fibrosis Liverpool |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation at international sysmposium on Molecular Medicine |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | "Antisense PNA antibiotics against multiresistant gram negative bacteria", Peter Nielsen, Fredrik Björling , Henrik Franzyk, 21st International Symposium on Molecular Medicine, Athens, Greece, October 2017 Presentation given by Peter Nielsen on behalf of the SENBIOTAR consortium to promote the work done under this consortium |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.spandidos-publications.com/pages/conference |
Description | Research Spotlight on the JPIAMR webpage |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | The highlights from the SENBIOTAR programme were disseminated through a research spotlight in the JPIAMR website which is openly accessible to everybody. It highlights the success of this particular programme as a way of promoting the outputs from the JPIAM funding. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.jpiamr.eu/wp-content/uploads/2019/10/JPIAMR_Folder_3xCase_Screen.pdf |
Description | SEMINAR TITLEL: Intercellular Signalling through quorum sensing: an area of unlimited opportunities |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | A research seminar at the University of Rio Cuarto in Argentina. There was a mixture of students, academics and researchers. As a consequence of the discussion that took place during the presentation further collaborations have arisen. |
Year(s) Of Engagement Activity | 2019 |
Description | Seminar and Shanghai Jiao Tong University |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Invited talk at Shanghai Jiao Tong University. TITLE: Targeting virulence in Pseudomonas aeruginosa as an alternative antibacterial strategy. Presenter: Miguel Camara. This meeting was used to present the results to SENBIOTAR to a broad Chinese audience with a view to explore future collaborations in the area of quorum sensing inhibition |
Year(s) Of Engagement Activity | 2017 |
Description | Seminar at National University of Colombia in Medellin 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Invited Seminar Universidad Nacional de Colombia in Medellin. Title: Versatilidad de los sistemas de señalización por quorum sensing en bacterias y sus aplicaciones. Presenter Miguel Camara. A collaborative research plan was developed upon this interaction. |
Year(s) Of Engagement Activity | 2016 |
Description | Seminar: Quorum sensing and Pseudomonas aeruginosa: signals, networks, biomarkers and infection |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | This presentation was given by Prof Paul Williams as part of the University of Manchester Infection Seminar Series. There was an opportunity to talk to students and staff about this topic before and after the presentation. |
Year(s) Of Engagement Activity | 2019 |
Description | TALK TITLE: Interfering with biofilm formation, signalling and virulence |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | This talk was part of the launch fo the Singapore National Biofilm Consortium. There was a mixed audience from the government, University VIPs (NUS and NTU Singapore), academics, industry and researchers. This presentation was part of the opening of a debate around different research priorities in the biofilm arena. |
Year(s) Of Engagement Activity | 2019 |
Description | TITLE: Discovery of novel Pseudomonas quinolone signal (pqs) antagonists for Pseudomonas aeruginosa infections |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | GP2A Medicinal Chemistry Conference 2019 to disseminate new discoveries in medicinal chemistry. The primary aim of this conference to enable exchange of ideas and experience between academics, PhD student and post-doctoral researchers and industry. |
Year(s) Of Engagement Activity | 2019 |
URL | http://gp2a.org/index.php/category/gp2a2019/ |
Description | TITLE: Novel strategies to target antimicrobial resistance: Inhibition of the pqs quorum sensing system in Pseudomonas aeruginosa to attenuate virulence |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | GP2A Medicinal Chemistry Conference 2019 to disseminate new discoveries in medicinal chemistry. The primary aim of this conference to enable exchange of ideas and experience between academics, PhD student and post-doctoral researchers and industry. This poster won the first prize |
Year(s) Of Engagement Activity | 2019 |
URL | http://gp2a.org/index.php/category/gp2a2019/ |
Description | TITLE:Title: Design, Synthesis and Evaluation of Novel PqsR Inhibitors as Adjuvant Therapy to Treat Pseudomonas aeruginosa Infections |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | GP2A Medicinal Chemistry Conference 2019 to disseminate new discoveries in medicinal chemistry. The primary aim of this conference to enable exchange of ideas and experience between academics, PhD student and post-doctoral researchers and industry. |
Year(s) Of Engagement Activity | 2019 |
URL | http://gp2a.org/index.php/category/gp2a2019/ |
Description | Talk at Central European Symposium on Antimicrobials and Antimicrobial Resistant |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Central European Symposium on Antimicrobials and Antimicrobial Resistant (CESAR), Šibenik, Croatia 2015-Invited talk Miguel Camara TITLE: Turning down quorum sensing in Pseudomonas aeruginosa as an antimicrobial strategy |
Year(s) Of Engagement Activity | 2015 |
URL | http://hmd-cms.hr/cesar2015/ |
Description | Talk at International Antimicrobial Resistance conference in Copenhagen |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | ICOHAR International Conference on One Health Antimicrobial Resistance, Copenhagen 2015- Invited Talk Miguel Camara TITLE: Targeting bacterial inter-cellular signalling as a therapeutic approach |
Year(s) Of Engagement Activity | 2015 |
URL | https://www.fp7-risksur.eu/news-events/icohar-2015-international-conference-one-health-antimicrobial... |
Description | Talk at Pseudomonas 2017 International Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | 16th International conference on Pseudomonas Liverpool 2017 TITLE: Dissecting and exploiting the pqs quorum sensing system in Pseudomonas aeruginosa Presenter: Miguel Camara |
Year(s) Of Engagement Activity | 2017 |
URL | https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2017-16th-internat... |
Description | Talk at conference on Peptides in Germany |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | "Peptides for Cellular and in vivo Delivery of PNA Antisense Agents", Peter Nielsen, XII German Peptide Symposium, Darmstadt, Germany, March, 2015. Some of the work on antimicrobial peptides from SENBIOTAR was presented at this conference |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.eurpepsoc.com/small-symposia/ |
Description | University of Tubingen International Summer School 'Microbes, Host and Infection, Bad Urach, Germany July 2018. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Delivered a talk entitled 'Alkylquinolones and Pseudomonas aeruginosa: a tale of regulatory networks, multi- functional signals and antibacterial targets' to both academics and Graduate students which resulted in extended discussions after the event increasing the interest of the graduates into this subject area. |
Year(s) Of Engagement Activity | 2018 |