Midlife Pace of Aging in the Dunedin Study
Lead Research Organisation:
King's College London
Department Name: Social Genetic and Dev Psychiatry Centre
Abstract
Declining fertility rates, aging of the baby-boomers, and increasing life expectancy are leading to population aging. As the population ages, this increases the public-health burden of age-related conditions, such as cardiovascular disease, type 2 diabetes, and dementia. Treating un-prevented diseases in late life has proven costly and ineffective. It is now known that potentially preventable risk exposures and physiological causes of age-related disease emerge in childhood. This recognition lends new scientific significance to studies that have followed cohorts from childhood. It is also now known that the pathogenesis of age-related diseases involves gradually accumulating decline in organ systems, beginning in the first half of the life course. Consequently, new interventions aiming to prevent age-related diseases will have to be applied to individuals while they are yet young, before they reach midlife. Translation of basic-science gerontology discoveries into preventive interventions for young humans is lacking because virtually nothing is known about the process of biological aging during the first half of the life course. This prompts our proposal to study the pace of biological aging from the twenties forward. We will use the Dunedin Multidisciplinary Health & Development Study, a longitudinal study of a birth cohort now entering its fifth decade. This study combines methods of demographic/economic surveys, clinical-quality health assessments, biobanking, and linkage to nationwide administrative records (health, welfare, finances). We propose to administer a full-day data-collection protocol to the 1004 living members of the birth cohort. To assess each cohort member's pace of biological aging we will: (a) measure biomarkers across multiple organ systems, and (b) statistically model correlated change in these biomarkers assessed at ages 26, 32, 38, and 45 years. We will describe individual variation in the pace of aging, plus its developmental origins, genomic signatures, functional consequences, associated cognitive changes, and economic costs. We will identify attributes that set apart individuals whose bodies are months or years younger than their chronological age. The proposed work will improve knowledge by generating findings to support future interventions during midlife or earlier, to slow aging, prevent age-related disease, and improve the quality of longer lives.
Technical Summary
Declining fertility rates, aging of the baby-boomers, and increasing life expectancy are leading to population aging. As the population ages, this increases the public-health burden of age-related conditions, such as cardiovascular disease, type 2 diabetes, and dementia. Treating un-prevented diseases in late life has proven costly and ineffective. It is now known that potentially preventable risk exposures and physiological causes of age-related disease emerge in childhood. It is also now known that the pathogenesis of age-related diseases involves gradually accumulating decline in organ systems, beginning in the first half of the life course. Consequently, new interventions aiming to prevent age-related diseases will have to be applied to individuals while they are yet young, before they reach midlife. Translation of basic-science geroscience discoveries into preventive interventions for young humans is lacking because virtually nothing is known about the process of biological aging during the first half of the life course. This prompts our proposal to study the pace of biological aging from the twenties forward. We will use the Dunedin Multidisciplinary Health & Development Study, a longitudinal study of a birth cohort now entering its fifth decade. We propose to administer a full-day data-collection protocol to the 1004 living members of the birth cohort. To assess each cohort member's pace of biological aging we will: (a) measure biomarkers across multiple organ systems, and (b) statistically model correlated change in these biomarkers assessed at ages 26, 32, 38, and 45 years. We will describe individual variation in the pace of aging, plus its developmental origins, genomic signatures, functional consequences, associated cognitive changes, and economic costs. We will identify attributes that set apart individuals whose bodies are months or years younger than their chronological age.
Planned Impact
Please see our "Pathways to Impact" statement for specific plans. Briefly...
The intended non-academic beneficiaries of this research are individuals who experience mental disorder, health-care providers, government, and taxpayers at large. Life expectancy is growing longer and longer. Policy makers and citizens
are concerned that our extra years of life should be healthy, productive, and enjoyable, not extra years of disease and disability. The hope of preventing age-related diseases and of increasing health expectancy requires research to identify candidate risk targets that can be treated successfully, in early life. Thus, our proposed research could potentially increase the political will to deliver preventions and treatments to individuals in midlife, before they develop age-related diseases. Such interventions in turn could reduce the burden of mental illness and age-related disease on the health-care delivery service. Reducing the burden of age-related diseases could in turn reduce costs to
government and taxpayers, and increase national productivity and wellbeing for the UK. Here we refer to the MRC Researchfish website's page entitled Dissemination of Research to Non-Academic Audiences for our MRC
Programme Grant, wherein we report the ways in which our research findings have been communicated to nonacademic users in the past 10 years. Full descriptions are provided for the following activities on the Researchfish site. We expect to engage in very similar dissemination activities in the next 5 years.
WWW.ALTMETRIC.COM records the following evidence of Dunedin Study impact beyond the ivory tower since September 2012: 132 published journal articles have 5,636 total mentions, in 262 unique newspaper-articles by science journalists, 232 blogs, 511 Facebook pages, 216 Wikipedia pages, 37 recommendations in Faculty-1000, and 4,148 twitters from 36 countries on all continents (Downloaded 2 September, 2015). In 2014 we were selected by Altmetric-UK as a demonstration research team at the 99th percentile on impact indicators across the different areas of clinical practice, social media, science media journalistic coverage, and policy documents originating in the UK.
In 2015 a 4-episode documentary film on our research was launched: Predict My Future: What makes us who we really are? http://www.moffittcaspi.com/content/science-us. This film series has been bought for distribution by BBC Asia: Brunei, Cambodia, China, Hong Kong, Indonesia, Laos, Macau, Malaysia, Mongolia, Myanmar, N Korea, Palua, Philippines, Singapore, S Korea, Taiwan, Thailand, & Vietnam. It has also been bought for distribution by Education TV Spain, Discovery Poland, Denmark, Sweden, Norway, and Qantas Airlines onboard entertainment. The documentary has only been marketed since December 2015, US and UK purchasers are expected.
High visibility public lectures by TE Moffitt and A Caspi, and our trainees, such as the 2013 Darwin Lecture at Cambridge, and the 2015 Keynote, International Convention of Psychological Science (ICPS)Amsterdam, both are on the internet.
Training videos disseminated to other research teams
Continuing-education teaching for medical professionals
As a result of these public dissemination activities, and others like them, our research under this programme grant
influences policy, as reported in detail on the MRC Researchfish website, which describes the recent examples below.
US Supreme Court Amicus Briefs
British Academy Policy Report
US National Academy of Sciences Panel on Demand for Drugs
Wrote DSM-V diagnosis for conduct disorder, ADHD and ODD
US National Cancer Institute Report
US Institute of Medicine Report
US National Academy of Sciences 21st Century Skills
Canadian Academy of Health Sciences Expert Panel
National Academy of Sciences, Advisory Committee on Law and Justice
Chair policy seminars at the Nuffield Foundation
Early Intervention Next Steps: A report to Her Majesty's Govt. by G Allen MP
The intended non-academic beneficiaries of this research are individuals who experience mental disorder, health-care providers, government, and taxpayers at large. Life expectancy is growing longer and longer. Policy makers and citizens
are concerned that our extra years of life should be healthy, productive, and enjoyable, not extra years of disease and disability. The hope of preventing age-related diseases and of increasing health expectancy requires research to identify candidate risk targets that can be treated successfully, in early life. Thus, our proposed research could potentially increase the political will to deliver preventions and treatments to individuals in midlife, before they develop age-related diseases. Such interventions in turn could reduce the burden of mental illness and age-related disease on the health-care delivery service. Reducing the burden of age-related diseases could in turn reduce costs to
government and taxpayers, and increase national productivity and wellbeing for the UK. Here we refer to the MRC Researchfish website's page entitled Dissemination of Research to Non-Academic Audiences for our MRC
Programme Grant, wherein we report the ways in which our research findings have been communicated to nonacademic users in the past 10 years. Full descriptions are provided for the following activities on the Researchfish site. We expect to engage in very similar dissemination activities in the next 5 years.
WWW.ALTMETRIC.COM records the following evidence of Dunedin Study impact beyond the ivory tower since September 2012: 132 published journal articles have 5,636 total mentions, in 262 unique newspaper-articles by science journalists, 232 blogs, 511 Facebook pages, 216 Wikipedia pages, 37 recommendations in Faculty-1000, and 4,148 twitters from 36 countries on all continents (Downloaded 2 September, 2015). In 2014 we were selected by Altmetric-UK as a demonstration research team at the 99th percentile on impact indicators across the different areas of clinical practice, social media, science media journalistic coverage, and policy documents originating in the UK.
In 2015 a 4-episode documentary film on our research was launched: Predict My Future: What makes us who we really are? http://www.moffittcaspi.com/content/science-us. This film series has been bought for distribution by BBC Asia: Brunei, Cambodia, China, Hong Kong, Indonesia, Laos, Macau, Malaysia, Mongolia, Myanmar, N Korea, Palua, Philippines, Singapore, S Korea, Taiwan, Thailand, & Vietnam. It has also been bought for distribution by Education TV Spain, Discovery Poland, Denmark, Sweden, Norway, and Qantas Airlines onboard entertainment. The documentary has only been marketed since December 2015, US and UK purchasers are expected.
High visibility public lectures by TE Moffitt and A Caspi, and our trainees, such as the 2013 Darwin Lecture at Cambridge, and the 2015 Keynote, International Convention of Psychological Science (ICPS)Amsterdam, both are on the internet.
Training videos disseminated to other research teams
Continuing-education teaching for medical professionals
As a result of these public dissemination activities, and others like them, our research under this programme grant
influences policy, as reported in detail on the MRC Researchfish website, which describes the recent examples below.
US Supreme Court Amicus Briefs
British Academy Policy Report
US National Academy of Sciences Panel on Demand for Drugs
Wrote DSM-V diagnosis for conduct disorder, ADHD and ODD
US National Cancer Institute Report
US Institute of Medicine Report
US National Academy of Sciences 21st Century Skills
Canadian Academy of Health Sciences Expert Panel
National Academy of Sciences, Advisory Committee on Law and Justice
Chair policy seminars at the Nuffield Foundation
Early Intervention Next Steps: A report to Her Majesty's Govt. by G Allen MP
Organisations
- King's College London (Lead Research Organisation)
- Columbia University (Collaboration)
- University of Oslo (Collaboration)
- National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) (Collaboration)
- University of Murcia, Spain (Collaboration)
- Broad Institute (Collaboration)
- Max Planck Society (Collaboration)
- Cardiff University (Collaboration)
- University of Pennsylvania (Collaboration)
- University of Otago (Collaboration)
- Singapore Eye Research Institute (Collaboration)
- University of Montreal (Collaboration)
- University of Bristol (Collaboration)
- Universidade de São Paulo (Collaboration)
- University of Copenhagen (Collaboration)
- University College London (Collaboration)
- Cambridge Cognition Ltd (Collaboration)
- MRC Harwell Institute (Collaboration)
- UNIVERSITY OF EXETER (Collaboration)
- Maastricht University (UM) (Collaboration)
- University of California, Irvine (Collaboration)
- Duke University (Collaboration)
- Free University of Amsterdam (Collaboration)
- Yale University (Collaboration)
- Global Burden of Disease Study (Collaboration)
Publications
Bourassa KJ
(2022)
Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife.
in JAMA pediatrics
Bourassa KJ
(2021)
Linking stressful life events and chronic inflammation using suPAR (soluble urokinase plasminogen activator receptor).
in Brain, behavior, and immunity
Brazil IA
(2020)
Staring at the (sur)face of the antisocial brain.
in The lancet. Psychiatry
Brennan G
(2024)
The Continuity of Adversity: Negative Emotionality Links Early Life Adversity With Adult Stressful Life Events
in Clinical Psychological Science
Brennan GM
(2023)
Tracing the origins of midlife despair: association of psychopathology during adolescence with a syndrome of despair-related maladies at midlife.
in Psychological medicine
Buffarini R
(2021)
Intimate partner violence against women and child maltreatment in a Brazilian birth cohort study: co-occurrence and shared risk factors.
in BMJ global health
Carlisi CO
(2021)
Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort.
in Development and psychopathology
Carlisi CO
(2020)
Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort.
in The lancet. Psychiatry
Caspi A
(2020)
Longitudinal Assessment of Mental Health Disorders and Comorbidities Across 4 Decades Among Participants in the Dunedin Birth Cohort Study.
in JAMA network open
Caspi A
(2018)
All for One and One for All: Mental Disorders in One Dimension.
in The American journal of psychiatry
Description | "Mental Disorders in Norway: A Public Health Perspective". (2018). In Norwegian: <>. Norwegian Institute of Public Health. The title translates to "Mental Health in Norway" and is about well-being and prevalence of mental disorders in Norway, published by The Norwegian Institute of Public Health. |
Geographic Reach | Europe |
Policy Influence Type | Citation in other policy documents |
Impact | "Mental Disorders in Norway: A Public Health Perspective". (2018). In Norwegian: <>. Norwegian Institute of Public Health. https://urldefense.proofpoint.com/v2/url?u=https-3A__www.fhi.no_globalassets_dokumenterfiler_rapporter_psykisk-2Dhelse_psykisk-5Fhelse-5Fi-5Fnorge2018.pdf&d=DwIFAw&c=imBPVzF25OnBgGmVOlcsiEgHoG1i6YHLR0Sj_gZ4adc&r=b2Fq6lZbKqVrnoF6oCx6ctmn6d7Ax7Th7OrHBLkeHgQ&m=Cebauj8UCrwHU9SNWcWUqWVED5vb4vLcFO9qjYuvBe0&s=HvGGyL_hJFsqdEZVBs-KvzyzLjiAFI4PAzOJ1iVy4UE&e= The title translates to "Mental Health in Norway" and is about well-being and prevalence of mental disorders in Norway, published by The Norwegian Institute of Public Health. |
URL | https://urldefense.proofpoint.com/v2/url?u=https-3A__www.fhi.no_globalassets_dokumenterfiler_rapport... |
Description | Evidence that childhood exposure to lead has longterm effects on brain |
Geographic Reach | North America |
Policy Influence Type | Contribution to a national consultation/review |
Impact | We published 4 papers showing that childhood exposure to lead has lasting effects on brain development to midlife, and on the basis of our data, many American cities have obtained government funding to replace lead pipes in the water system. Most recently Newark New Jersey. |
Description | Nuffield Council on bioethics Briefing note: the search for a treatment for ageing |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | Nuffield Council on Bioethics, Briefing note: The search for a treatment for ageing. Cites 5 of our publications. (2018) |
Description | Podcast: https://ajp.psychiatryonline.org/pb/assets/raw/journals/ajp/audio/2019/March_2019.mp3 |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Podcast on selfharm: https://ajp.psychiatryonline.org/pb/assets/raw/journals/ajp/audio/2019/March_2019.mp3 |
URL | https://ajp.psychiatryonline.org/pb/assets/raw/journals/ajp/audio/2019/March_2019.mp3 |
Description | Recommendations of our publications on F1000PRIME, F1000 of Medicine, and F1000 of Biology. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Since 2002, a full 28 of our publications have been recommended on F1000PRIME. This is a well-known worldwide extraction service for medicine and biology. Papers are recommended as "example of excellence", "changes clinical Practice", "challenges prior research," or "useful new method." |
URL | https://f1000.com/prime/articles/all?fieldsCriteria%5b0%5d.fieldName=AUTHOR&fieldsCriteria%5b0%5d.op... |
Description | Midlife Aging in the Dunedin Study Phase 52 |
Amount | £1,321,366 (GBP) |
Funding ID | MR/X021149/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2023 |
End | 09/2028 |
Description | NIA Dunedin Phase 45 grant |
Amount | $3,000,000 (USD) |
Funding ID | 1R01AG049789-01 |
Organisation | National Institutes of Health (NIH) |
Department | National Institute on Aging |
Sector | Public |
Country | United States |
Start | 08/2022 |
End | 08/2027 |
Description | NIA Neuroimaging grant |
Amount | $7,000,000 (USD) |
Funding ID | 2 R01 AG032282-06 |
Organisation | National Institutes of Health (NIH) |
Department | National Institute on Aging |
Sector | Public |
Country | United States |
Start | 06/2022 |
End | 06/2027 |
Title | DunedinPACE an epigenetic measure of the whole-body pace of human biological aging |
Description | DunedinPACE an epigenetic measure of the whole-body pace of human biological aging |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | Imported into 28 large cohort studies, generated >40 publications by other teams |
Description | Anita Thapar ADHD trajectory project |
Organisation | Cardiff University |
Department | Cardiff Synthetic Biology Initiative |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | data collaboration |
Collaborator Contribution | data collaboration |
Impact | not yet |
Start Year | 2018 |
Description | Bristol University dept of psychology |
Organisation | University of Bristol |
Department | School of Experimental Psychology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | collaborate on papers sponsoring a postdoc Lucy Bowes |
Collaborator Contribution | ideas |
Impact | several papers |
Start Year | 2011 |
Description | Cambridge Cognition, CANTAB |
Organisation | Cambridge Cognition Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Using the CANTAB data collection system |
Collaborator Contribution | they provided the CANTAB system of neuropsychological testing for our data collection |
Impact | data protocol |
Start Year | 2009 |
Description | Cardiff Univ replicating genetic findings |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | replication of genetic findings across cohorts |
Collaborator Contribution | replication of genetic findings across cohorts |
Impact | Caspi, Thapar, et al. 2008 |
Start Year | 2006 |
Description | Columbia Univ School of Public Health |
Organisation | Columbia University |
Department | School of Public Health |
Country | United States |
Sector | Academic/University |
PI Contribution | we provide data |
Collaborator Contribution | Columbia provides funded young researcher |
Impact | none yet |
Start Year | 2012 |
Description | Duke University Geriatrics School of Medicine |
Organisation | Duke University |
Department | School of Medicine Duke |
Country | United States |
Sector | Academic/University |
PI Contribution | coauthor papears |
Collaborator Contribution | coauthor papers |
Impact | PNAS publication |
Start Year | 2014 |
Description | Duke University Institute of Genome Science & Policy, Psychology & Neuroscience |
Organisation | Duke University |
Department | Insitute of Genome Sciences and Policy |
Country | United States |
Sector | Academic/University |
PI Contribution | We provide data and staff time |
Collaborator Contribution | joint appointments for staff |
Impact | all our publications since 2007 |
Start Year | 2007 |
Description | Duke university co-directing phase 18 |
Organisation | Duke University |
Department | Insitute of Genome Sciences and Policy |
Country | United States |
Sector | Academic/University |
PI Contribution | Moffitt and Caspi have joint appointments at Duke, and are co-investigators in phase 18 of the E-risk study led by Louise Arseneault |
Collaborator Contribution | ideas |
Impact | Phase 18 data collection |
Description | EU GEne environment interplay network |
Organisation | Maastricht University (UM) |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Chair of Advisory Board, Caspi |
Collaborator Contribution | ideas |
Impact | na |
Start Year | 2011 |
Description | Evan Macosko, Genomics, Broad Institute, MIT. |
Organisation | Broad Institute |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Shared depletable tissue |
Collaborator Contribution | New Technology |
Impact | genomics |
Start Year | 2021 |
Description | Global Burden of Disease |
Organisation | Global Burden of Disease Study |
Country | Global |
Sector | Academic/University |
PI Contribution | collaborate |
Collaborator Contribution | collaborate |
Impact | 3 publications |
Start Year | 2011 |
Description | Global burden of Disease |
Organisation | Global Burden of Disease Study |
Country | Global |
Sector | Academic/University |
PI Contribution | coauthor |
Collaborator Contribution | run the GBD |
Impact | publications |
Start Year | 2013 |
Description | Go-DMC methylation consortium |
Organisation | University of Exeter |
Department | Exeter University Arts Faculty |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | data collaboration |
Collaborator Contribution | data collaboration |
Impact | none yet |
Start Year | 2018 |
Description | MAx Planck Institute of Psychiatry |
Organisation | Max Planck Society |
Department | Max Planck Institute of Psychiatry |
Country | Germany |
Sector | Academic/University |
PI Contribution | replication on findings in independent studies |
Collaborator Contribution | replication of findings |
Impact | publication |
Start Year | 2010 |
Description | MRC HArwell |
Organisation | MRC Harwell |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | datasets |
Collaborator Contribution | coauthors papers |
Impact | Publicaton |
Start Year | 2012 |
Description | Murcia Spain studies of child injury |
Organisation | University of Murcia, Spain |
Country | Spain |
Sector | Academic/University |
PI Contribution | we provided data and co wrote paper |
Collaborator Contribution | data and idea exchange, visiting professor |
Impact | 1 publication |
Start Year | 2007 |
Description | PROMENTA Centre University of Oslo Norway |
Organisation | University of Oslo |
Country | Norway |
Sector | Academic/University |
PI Contribution | PROMENTA Centre University of Oslo Norway |
Collaborator Contribution | collab |
Impact | Psychology, public health |
Start Year | 2018 |
Description | Singapore Eye Inst Retinal micro-vasculature |
Organisation | Singapore Eye Research Institute |
Country | Singapore |
Sector | Academic/University |
PI Contribution | we contributed the cohort sample, and wrote the papers |
Collaborator Contribution | SERI did the grading of digital retinal photos |
Impact | 2 papers in press |
Start Year | 2010 |
Description | SuPAR project |
Organisation | University of Copenhagen |
Department | Center for Healthy Aging |
Country | Denmark |
Sector | Academic/University |
PI Contribution | data collaboration |
Collaborator Contribution | assays collaboration |
Impact | 2 publications |
Start Year | 2018 |
Description | The Dunedin Multidisciplinary Health & Development Study, Otago School of Medicine |
Organisation | University of Otago |
Department | Dunedin Multidisciplinary Health & Development Research Unit |
Country | New Zealand |
Sector | Academic/University |
PI Contribution | We raised funds and designed protocols and analysed the data |
Collaborator Contribution | the Unit at Otago runs the cohort study and undertakes data-collection waves |
Impact | over 1000 publications |
Description | UCL psychology stuides of callous unemotional traits |
Organisation | University College London |
Department | Division of Psychology & Language Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | we co wrote papers with dr viding |
Collaborator Contribution | idea and data exchange |
Impact | 3 publications |
Start Year | 2007 |
Description | Univ of Calif at Irvine Neighbourhood REsearch |
Organisation | University of California, Irvine |
Country | United States |
Sector | Academic/University |
PI Contribution | E-risk data sharing with team at UC Irvine who has geocoded indicators of neighbourhood level health and poverty indicators to study hwo these affect children's mental health development. |
Collaborator Contribution | augmented data base |
Impact | 6 papers in the analysis stage |
Start Year | 2008 |
Description | Univ of Montreal Dept of Criminology |
Organisation | University of Montreal |
Department | School of Criminology |
Country | Canada |
Sector | Academic/University |
PI Contribution | collaborate on publications |
Collaborator Contribution | ideas |
Impact | several papers |
Start Year | 2011 |
Description | Univ of Pennsylvania studies of child abuse |
Organisation | University of Pennsylvania |
Department | Department of Psychology |
Country | United States |
Sector | Academic/University |
PI Contribution | we provided data |
Collaborator Contribution | data and idea exchange |
Impact | 2 articles |
Start Year | 2007 |
Description | University of Otago replications of genetic findings |
Organisation | University of Otago |
Department | Dunedin School of Medicine |
Country | New Zealand |
Sector | Academic/University |
PI Contribution | WE replicated findings from the NZ Dunedin cohort in the UK E-risk cohort. |
Collaborator Contribution | sister studies in two countries, both funded in part by MRC, we can build in replication checks for any and all findings |
Impact | 4 articles, reported to MRC eval under our other grant, for the Dunedin Study. All are multidisciplinary, involving genetics and pscyhiatry and psychology. |
Start Year | 2006 |
Description | University of São Paulo Medical School and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil. |
Organisation | National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) |
Country | Brazil |
Sector | Academic/University |
PI Contribution | shared data, replicated findings |
Collaborator Contribution | ideas, publicationsideas, publications |
Impact | publications |
Start Year | 2007 |
Description | University of São Paulo Medical School and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil. |
Organisation | Universidade de São Paulo |
Country | Brazil |
Sector | Academic/University |
PI Contribution | shared data, replicated findings |
Collaborator Contribution | ideas, publicationsideas, publications |
Impact | publications |
Start Year | 2007 |
Description | Yale University studies of child risk |
Organisation | Yale University |
Department | Department of Psychology |
Country | United States |
Sector | Academic/University |
PI Contribution | we provided data |
Collaborator Contribution | idea exchange and data exchange |
Impact | 2 articles |
Start Year | 2008 |
Description | methylation and gene expression |
Organisation | Free University of Amsterdam |
Department | Department of Chemistry and Pharmaceutical Sciences |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | data collaboration |
Collaborator Contribution | multi-study |
Impact | 3 publications |
Start Year | 2018 |
Title | DunedinPACE |
Description | DNAmethylation algorithm to measure pace of human aging |
Type Of Technology | New/Improved Technique/Technology |
Year Produced | 2021 |
Open Source License? | Yes |
Impact | adopted by many cohort studies |
URL | https://elifesciences.org/articles/73420#content |
Description | 3-page story about our research in the journal: Science. |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | 3-page feature article about our careers in the Dunedin Study. |
Year(s) Of Engagement Activity | 2018 |
URL | http://science.sciencemag.org/content/359/6375/510.full |
Description | Belsky, Jay, Moffitt, TE, Poulton, R, Caspi, A. (2020). The Origins of You, How Childhood Shapes Later Life. Harvard University Press. https://us4.campaign-archive.com/?u=5edd9a1c2f220702e75c13563&id=54172ed885 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Belsky, Jay, Moffitt, TE, Poulton, R, Caspi, A. (2020). The Origins of You, How Childhood Shapes Later Life. Harvard University Press. https://us4.campaign-archive.com/?u=5edd9a1c2f220702e75c13563&id=54172ed885 |
Year(s) Of Engagement Activity | 2020 |
Description | Human Nature Observed, Science Magazine article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Feature article about our work: commissioned by Science magazine. Starr, Douglas, Human nature, observed: For decades, two psychologists have kept watch over 1000 New Zealanders, teasing out factors that shape a life's course. Science 02 Feb 2018: Vol. 359, Issue 6375, pp. 510-513. DOI: 10.1126/science.359.6375.510 http://science.sciencemag.org/content/359/6375/510.full |
Year(s) Of Engagement Activity | 2018 |
URL | http://science.sciencemag.org/content/359/6375/510.full |
Description | New Scientist, "The p factor." Cover Story feature article about our work by Dan Jones. https://www.newscientist.com/article/mg24532660-500-a-radical-idea-suggests-mental-health-conditions-have-a-single-cause/ |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | New Scientist, "The p factor." Cover Story feature article about our work by Dan Jones. https://www.newscientist.com/article/mg24532660-500-a-radical-idea-suggests-mental-health-conditions-have-a-single-cause/ |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.newscientist.com/article/mg24532660-500 |
Description | New Scientist, Q&A with Terrie Moffitt: Can a young person's genes really set them up for a life of crime? by Dan Jones. https://www.newscientist.com/article/mg24732901-500-can-a-young-persons-genes-really-set-them-up-for-a-life-of-crime/ |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | New Scientist, Q&A with Terrie Moffitt: Can a young person's genes really set them up for a life of crime? by Dan Jones. https://www.newscientist.com/article/mg24732901-500-can-a-young-persons-genes-really-set-them-up-for-a-life-of-crime/ |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.newscientist.com/article/mg24732901-500 |
Description | Science Magazine/Jacobs Foundation BOLD Podcast Episode 2: Could studying children teach us about ageing? With Terrie Moffitt and Avshalom Caspi Join Sean Sanders, Director and Senior Editor for Custom Publishing at Science, as he interviews outstanding researchers in a broad range of fields whose work either directly involves the study of children and adolescents or has a significant impact in their lives. https://bold.expert/the-bold-podcast-episode-two/ |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Science Magazine/Jacobs Foundation BOLD Podcast Episode 2: Could studying children teach us about ageing? With Terrie Moffitt and Avshalom Caspi Join Sean Sanders, Director and Senior Editor for Custom Publishing at Science, as he interviews outstanding researchers in a broad range of fields whose work either directly involves the study of children and adolescents or has a significant impact in their lives. https://bold.expert/the-bold-podcast-episode-two/ |
Year(s) Of Engagement Activity | 2021 |
URL | https://bold.expert/the-bold-podcast-episode-two/ |
Description | The New Scientist article |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | New Scientist, The p factor. Cover Story feature article about our work by Dan Jones. https://www.newscientist.com/article/mg24532660-500-a-radical-idea-suggests-mental-health-conditions-have-a-single-cause/ |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.newscientist.com/article/mg24532660-500-a-radical-idea-suggests-mental-health-conditions... |
Description | gaitspeed BBC news |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC News: https://apple.news/AxSfOHLz8TCCd_pXltKmohQ |
Year(s) Of Engagement Activity | 2019 |
URL | https://apple.news/AxSfOHLz8TCCd_pXltKmohQ |