Centre for Integrated research into Musculoskeletal Ageing (CIMA) Renewal
Lead Research Organisation:
University of Liverpool
Department Name: Institute of Ageing and Chronic Disease
Abstract
Overview
The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) is a unique team. CIMA brings in a mix of skills from three major U.K. Universities: Liverpool, Newcastle and Sheffield. It helps doctors and lab scientists to work together to grasp:
1) How our muscles, bones and joints change as we age.
2) How this makes some people prone to problems with these tissues such as arthritis and osteoporosis.
3) What each person can do to reduce the risk of developing these problems.
Progress So Far
CIMA was first funded for 5 years in 2012. CIMA has made great progress in figuring out some key processes in muscles, bones and joints as we age. As well as working out what might reduce the risk of developing these problems, we have also done trials of some likely nutritional agents. These might reduce age-related decline in muscles, bones and joints. We have obtained some early evidence that raising vitamin D may help reduce age-related decline, but putting up nitrate intake may not help. A big limit to expanding research in this important area has also been a lack of well-trained researchers and doctors. So the Centre has also developed and run good training courses to meet this need.
Future: Targets, Treatments & Training
This bid is for 5 more years of funding from the Medical Research Council (MRC) and Arthritis Research UK to help build on this work. Our first phase of funding has let the CIMA members spot certain changes to cells- called epigenetic changes. These seem vital in influencing whether muscles, bones and joint tissues decline quickly or slowly as we age. We plan to do a linked research programme across Liverpool, Newcastle and Sheffield. This will seek to work out the importance of these changes and whether we can modify the changes to reduce the risk of getting muscle, bone and joint problems. We will also work together to look more closely at whether nutrition and exercise can prevent or reduce the risk of these problems. We also plan to expand our training programme so more basic scientists and doctors can do excellent research into these problems. Key results will be shared in papers and meetings. More funding bids will be made to do this work.
Patient View
People with arthritis have helped to shape this bid. By joining a series of "Arthritis Matters" Public Engagement events, for example. These have helped the public grasp CIMA's research and shape future priorities. Above all this includes a grasp of new arthritis treatments and how study findings can benefit patients. We also asked a group of 15 patients to advise on the final lay summary. We think talking to patients often about research and listening to their views makes for better research.
Better Engagement
Going forward, patients and the public will continue to be actively involved by providing insight and valued feedback in many ways. Face to face meetings will remain a key part. And more events will be used, including local, national and global schemes. There will be new work with schools, to share CIMA's work, inspire new ideas and nurture talent. The VOICE North digital platform will support this across the Centre and more widely. The CIMA website will also be kept up to date and advances shared on Twitter. We know most older people don't use these yet, but that could change quickly as access gets easier and cheaper. We expect young people to help make solutions for this. We will also increase our work with drug companies, local authorities and the NHS. This will allow us to develop ways to make sure our findings are quickly put into practice to benefit older people. Arthritis is also one of a key number of conditions included in the NIHR James Lind Alliance Priority Setting Partnership on Ageing and Multiple conditions, led by Newcastle University. This will provide more chances for patients who have arthritis to be involved and link to CIMA.
The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) is a unique team. CIMA brings in a mix of skills from three major U.K. Universities: Liverpool, Newcastle and Sheffield. It helps doctors and lab scientists to work together to grasp:
1) How our muscles, bones and joints change as we age.
2) How this makes some people prone to problems with these tissues such as arthritis and osteoporosis.
3) What each person can do to reduce the risk of developing these problems.
Progress So Far
CIMA was first funded for 5 years in 2012. CIMA has made great progress in figuring out some key processes in muscles, bones and joints as we age. As well as working out what might reduce the risk of developing these problems, we have also done trials of some likely nutritional agents. These might reduce age-related decline in muscles, bones and joints. We have obtained some early evidence that raising vitamin D may help reduce age-related decline, but putting up nitrate intake may not help. A big limit to expanding research in this important area has also been a lack of well-trained researchers and doctors. So the Centre has also developed and run good training courses to meet this need.
Future: Targets, Treatments & Training
This bid is for 5 more years of funding from the Medical Research Council (MRC) and Arthritis Research UK to help build on this work. Our first phase of funding has let the CIMA members spot certain changes to cells- called epigenetic changes. These seem vital in influencing whether muscles, bones and joint tissues decline quickly or slowly as we age. We plan to do a linked research programme across Liverpool, Newcastle and Sheffield. This will seek to work out the importance of these changes and whether we can modify the changes to reduce the risk of getting muscle, bone and joint problems. We will also work together to look more closely at whether nutrition and exercise can prevent or reduce the risk of these problems. We also plan to expand our training programme so more basic scientists and doctors can do excellent research into these problems. Key results will be shared in papers and meetings. More funding bids will be made to do this work.
Patient View
People with arthritis have helped to shape this bid. By joining a series of "Arthritis Matters" Public Engagement events, for example. These have helped the public grasp CIMA's research and shape future priorities. Above all this includes a grasp of new arthritis treatments and how study findings can benefit patients. We also asked a group of 15 patients to advise on the final lay summary. We think talking to patients often about research and listening to their views makes for better research.
Better Engagement
Going forward, patients and the public will continue to be actively involved by providing insight and valued feedback in many ways. Face to face meetings will remain a key part. And more events will be used, including local, national and global schemes. There will be new work with schools, to share CIMA's work, inspire new ideas and nurture talent. The VOICE North digital platform will support this across the Centre and more widely. The CIMA website will also be kept up to date and advances shared on Twitter. We know most older people don't use these yet, but that could change quickly as access gets easier and cheaper. We expect young people to help make solutions for this. We will also increase our work with drug companies, local authorities and the NHS. This will allow us to develop ways to make sure our findings are quickly put into practice to benefit older people. Arthritis is also one of a key number of conditions included in the NIHR James Lind Alliance Priority Setting Partnership on Ageing and Multiple conditions, led by Newcastle University. This will provide more chances for patients who have arthritis to be involved and link to CIMA.
Technical Summary
The MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) brings together scientific and clinical expertise in different disciplines from the universities of Liverpool, Newcastle and Sheffield. Formed in 2012, CIMA has developed an integrated approach to study the effects of ageing on the musculoskeletal system, which has been demonstrably successful. CIMA has focussed activities in areas of critical mass where collaborations have provided enhanced value. These include the role of epigenetic changes in cells and tissues affected by musculoskeletal ageing, development of an assessment protocol for monitoring age-related decline in the musculoskeletal system (the CIMA Toolkit), and proof of principle pre-clinical and human studies to identify interventions that reduce the deleterious effects of ageing on the musculoskeletal system. CIMA has developed an innovative graduate training programme and undertaken well-received public engagement activities. The revised CIMA strategy will be increasingly translational, but informed by basic research. Specifically, we will; determine how epigenetic changes in the ageing musculoskeletal system influence the risk of musculoskeletal disorders, the effect of modification of epigenetic changes on musculoskeletal function, and the effect of lifestyle changes on epigenetic marks and molecules; design and implement interventions based on physical activity, nutrition, anti-inflammatory or age-retarding agents on decline of the ageing musculoskeletal system; extend the CIMA training programme to increase MRes, PhD and clinical training, and; develop engagement and impact activities to increase involvement of patients and the older population, and work with industry and other partners to maximise translation of our research discoveries. Finally, it will provide a resilience that will ensure musculoskeletal ageing moves to the centre of medical research activities within and beyond the UK.
Planned Impact
CIMA renewal will contribute to all key impacts, including advancement of scientific knowledge, health and wellbeing, economic competitiveness, policy development and the provision of skilled people to the workforce. Our activities will supplement and complement existing programmes, harnessing the best practice at each of the centres to deliver excellence at all. In every area, the process will be a dialogue or platform of co-discovery, where both sides benefit from improved knowledge and understanding.
Benefits are targeted to the aging population and those who have conditions that are associated with accelerated ageing, for example those with systemic and local joint inflammation.
Potential impacts to the ageing population from advances in scientific knowledge include:
- direct benefits including learning and empowerment from contributing to the design and delivery of studies
- Improved ability to monitor age-related decline of the entire musculoskeletal system and the effects of potential interventions to reduce this through use of the CIMA Toolkit
- benefits from involvement in effective shared decision making using tools like FRAX for assessing fracture risk.
- wider understanding of musculoskeletal ageing from PPI and patient engagement, VOICENorth (Quote: 'We are volunteering the accumulated knowledge we have gathered over our entire life'.)
- better information about healthy ageing and how to achieve it from better trained experts and improved personal engagement from platforms including VOICENorth online and the MOOC.- enhanced understanding of mechanisms and targets, feeding directly into accelerated novel drug identification and development
- refining outcomes and delivering interventions that improve care and both scientific and clinical practice
Impacts for health and wellbeing include:
- improved pain, function and quality of life from participation in clinical trials and accruing to the wider population once interventions are proven effective
- high standard of care related to being involved in a clinical trial
- avoidance of harm from better targeting of therapy and toxicity identification of widely used drugs, such as paracetamol
- improved treatment options and prognostication
Impacts on economic competitiveness include:
- investment in research, delivering economic benefits for the centre and wider economy by a) health gains net of the cost of delivery, b) GDP gains from the activity and further stimulated activity
- these will come from new biomarkers, assessment tools, nutritional supplements and drugs, training and engagement activity
Impacts on policy development will include:
- benefits of more effective care, driven by NICE and other guidelines
- briefing MPs; advising expert panels, select committees, the Foresight programme (such as 'Future of an Ageing Population', 2016); WHO
- collaboration and advisory work for industry, including the CIMA Industrial Strategy Board
Impacts on provision of skilled workforce will include:
- better education and proactive identification of talented scientists from early identification and support for innovation from school sixth form onwards
- enhanced awareness of musculoskeletal ageing in trainee scientists and clinicians arising from exposure to the CIMA MOOC
- support for MRes and PhD students, postdoctoral and tenured scientists, who will contribute to training the next generation, specifically training to increase understanding of PPI and engagement.
- closer industry links leading to both funding of education and scientific posts by industry and flow of highly skilled workforce between academia and industry
Benefits are targeted to the aging population and those who have conditions that are associated with accelerated ageing, for example those with systemic and local joint inflammation.
Potential impacts to the ageing population from advances in scientific knowledge include:
- direct benefits including learning and empowerment from contributing to the design and delivery of studies
- Improved ability to monitor age-related decline of the entire musculoskeletal system and the effects of potential interventions to reduce this through use of the CIMA Toolkit
- benefits from involvement in effective shared decision making using tools like FRAX for assessing fracture risk.
- wider understanding of musculoskeletal ageing from PPI and patient engagement, VOICENorth (Quote: 'We are volunteering the accumulated knowledge we have gathered over our entire life'.)
- better information about healthy ageing and how to achieve it from better trained experts and improved personal engagement from platforms including VOICENorth online and the MOOC.- enhanced understanding of mechanisms and targets, feeding directly into accelerated novel drug identification and development
- refining outcomes and delivering interventions that improve care and both scientific and clinical practice
Impacts for health and wellbeing include:
- improved pain, function and quality of life from participation in clinical trials and accruing to the wider population once interventions are proven effective
- high standard of care related to being involved in a clinical trial
- avoidance of harm from better targeting of therapy and toxicity identification of widely used drugs, such as paracetamol
- improved treatment options and prognostication
Impacts on economic competitiveness include:
- investment in research, delivering economic benefits for the centre and wider economy by a) health gains net of the cost of delivery, b) GDP gains from the activity and further stimulated activity
- these will come from new biomarkers, assessment tools, nutritional supplements and drugs, training and engagement activity
Impacts on policy development will include:
- benefits of more effective care, driven by NICE and other guidelines
- briefing MPs; advising expert panels, select committees, the Foresight programme (such as 'Future of an Ageing Population', 2016); WHO
- collaboration and advisory work for industry, including the CIMA Industrial Strategy Board
Impacts on provision of skilled workforce will include:
- better education and proactive identification of talented scientists from early identification and support for innovation from school sixth form onwards
- enhanced awareness of musculoskeletal ageing in trainee scientists and clinicians arising from exposure to the CIMA MOOC
- support for MRes and PhD students, postdoctoral and tenured scientists, who will contribute to training the next generation, specifically training to increase understanding of PPI and engagement.
- closer industry links leading to both funding of education and scientific posts by industry and flow of highly skilled workforce between academia and industry
Organisations
- University of Liverpool (Lead Research Organisation)
- NHS England (Collaboration)
- ASTON UNIVERSITY (Collaboration)
- University of Michigan (Collaboration)
- University of California, San Francisco (Collaboration)
- LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (Collaboration)
- McMaster University (Collaboration)
- Australian Catholic University (Collaboration)
- Amgen Inc (Collaboration)
- University of Sheffield (Collaboration)
- United Kingdom Research and Innovation (Collaboration)
- Florida Atlantic University (Collaboration)
- University of Belgrade (Collaboration)
- VERSUS ARTHRITIS (Collaboration)
- University of Montreal (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- UNIVERSITY OF LEEDS (Collaboration)
- Nuchido (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
- University of Bristol (Collaboration)
- University of Manchester (Collaboration)
- HARVARD UNIVERSITY (Collaboration)
- British Society of Lifestyle Medicine (Collaboration)
- Deakin University (Collaboration)
- McGill University (Collaboration)
- Vivobarefoot Ltd (Collaboration)
- Newcastle University (Collaboration)
- International Osteoporosis Foundation (Collaboration)
- NORTHUMBRIA UNIVERSITY (Collaboration)
- New Amsterdam Sciences (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- Southern Cross University (Collaboration)
- Apex Molecular (Collaboration)
- University College Ghent (Collaboration)
- Kayser Space (Collaboration)
Publications
Li CKH
(2021)
Safety and Tolerability of Subcutaneous Methotrexate in Routine Clinical Practice.
in Arthritis care & research
Brumwell A
(2022)
Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk.
in Arthritis research & therapy
Kehayova Y
(2023)
Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues
in Arthritis Research & Therapy
Hulme CH
(2018)
Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation.
in Arthritis research & therapy
Ramos-Mucci L
(2022)
The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics.
in Arthritis research & therapy
Shepherd C
(2019)
Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.
in Arthritis research & therapy
Ramos-Mucci L
(2020)
Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis.
in Arthritis research & therapy
Kung L
(2019)
Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis
in Arthritis Research & Therapy
Martins RR
(2018)
How to Catch a Smurf? - Ageing and Beyond In vivo Assessment of Intestinal Permeability in Multiple Model Organisms.
in Bio-protocol
Caraher MC
(2018)
Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a rodent model of oestrogen deficiency.
in Biochimica et biophysica acta. Molecular basis of disease
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Policy Influence Type | Contribution to a national consultation/review |
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Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
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Policy Influence Type | Participation in a guidance/advisory committee |
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Description | Schini - PHPT guidelines |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a guidance/advisory committee |
Impact | Affected clinical practice worldwide |
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Policy Influence Type | Participation in a guidance/advisory committee |
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URL | https://www.nice.org.uk/guidance/ng226 |
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Sector | Charity/Non Profit |
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Organisation | Versus Arthritis |
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End | 08/2027 |
Description | Aintree Arthritis Trust (Moots, Wright, Edwards) |
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Sector | Charity/Non Profit |
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End | 08/2026 |
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Amount | £385,108 (GBP) |
Funding ID | BB/T002115/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2019 |
End | 08/2022 |
Description | Assessing the lifetime risk of osteoarthritis acquired during foetal development |
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Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2023 |
End | 03/2025 |
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Sector | Charity/Non Profit |
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Amount | £80,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2025 |
Description | BBSRC CRISPR-interference Screening Centre (Eeden, Renshaw, Wilkinson) |
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Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | BBSRC DTP - Rice - Applying a novel PROTAC technology in stem cells to elucidate the regulatory role of transcription factors in cartilage ageing |
Amount | £120,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2022 |
Description | BBSRC In Vivo Skills award (Pekovic-Vaughan et al) |
Amount | £12,300 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | BBSRC Summer studentship (Peffers) |
Amount | £2,500 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | BBSRC-CASE - Miwa, von Zglincki, Magalhaes - Developing a multi-level pipeline for senolytics discoveries |
Amount | £95,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2022 |
End | 09/2025 |
Description | BRC MIlkMAN (Granic, Stevenson, Aspray, Sayer) |
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Sector | Private |
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Sector | Private |
Country | United States |
Start | 02/2023 |
Description | Balasubramanina, Eastell - Family mapping of previously identified HPP patients using predictive genotyping and detailed phenotyping approach |
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Organisation | Alexion Pharmaceuticals |
Sector | Private |
Country | United States |
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Sector | Charity/Non Profit |
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Start | 01/2024 |
End | 08/2026 |
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Sector | Private |
Country | United Kingdom |
Start |
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Sector | Charity/Non Profit |
Country | United Kingdom |
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Sector | Public |
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End | 05/2023 |
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Organisation | Alkaptonuria Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2020 |
End | 11/2022 |
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Amount | £1,500,000 (GBP) |
Organisation | Alkaptonuria Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 02/2027 |
Description | Bou-Gharios, Pekovic-Vaughan - Developing novel transgenic models of AKU using Nrf2-based system |
Amount | £70,000 (GBP) |
Organisation | Alkaptonuria Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2023 |
End | 04/2026 |
Description | Briggs - Defining the role of aggrecan and type IX collagen in osteoarthritis and osteochondritis dissecans through in vivo studies of genetic bone diseases |
Amount | £648,324 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2022 |
End | 07/2025 |
Description | CRISPR-based genome and epigenome perturbation in stem cells to understand and reverse osteoarthritis risk |
Amount | £120,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2023 |
End | 08/2027 |
Description | CRUK Pioneer Award (Zglinicki) |
Amount | £200,000 (GBP) |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Circadian Rhythms in the light of COVID-19: Formulating optimal time-of-day regimens for antiviral drugs using human 3D models and in silico modelling |
Amount | £343,559 (GBP) |
Funding ID | BB/W010801/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2021 |
End | 05/2024 |
Description | Circadian disruption and fibrosis progression in Systemic Sclerosis: towards improved prognosis and chrono-based therapeutic stratification |
Amount | £129,781 (GBP) |
Funding ID | CF-2021-2 133 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2022 |
End | 12/2025 |
Description | Circadian rhythms and the control of NRF2-based antioxidant signalling as a therapeutic target in dermal tissue repair and pathological wound healing |
Amount | £448,442 (GBP) |
Funding ID | MR/P003311/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2017 |
End | 01/2021 |
Description | Clegg - Tendon repair approach |
Amount | £237,000 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 03/2023 |
End | 03/2024 |
Description | Clinical Consequences of Adult-Presenting Hypophosphatasia with Special Focus on Gait, Bone Microarchitecture and Cognition: the PORTRAIT Study |
Amount | £222,719 (GBP) |
Organisation | Alexion |
Sector | Private |
Country | Germany |
Start |
Description | Co-design of community pharmacy-supported group consultations for the prevention and management of long-term conditions. |
Amount | £65,000 (GBP) |
Organisation | Northumbria University |
Sector | Academic/University |
Country | United Kingdom |
Start | 05/2023 |
End | 05/2027 |
Description | Comerford, Peffers - Identification of small non-coding RNAs in canine cranial cruciate ligament disease as diagnostic markers and therapeutic targets |
Amount | £178,604 (GBP) |
Organisation | Petplan Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2021 |
End | 10/2024 |
Description | Cristofolini - METASTRA: Computer-aided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through robust computational models validated in clinical settings |
Amount | € 6,000,000 (EUR) |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start |
Description | Cuthbertson - Multi-organ abnormality prevalence in type 2 diabetes mellitus |
Amount | £165,166 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start |
Description | D'Aout - Making better fitting leg prostheses: quantifying in-socket motion of the stump using biplanar X-Ray videography. |
Amount | £9,906 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | D'Aout - ODA Research Seed Fund |
Amount | £5,730 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | D'Aout - Translational Research Access Programme 2019 |
Amount | £62,426 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | D'Aout, Zheng, Bou-Gharios - Machine learning for automatic gait detection in mice |
Amount | £2,800 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | D'Aout- Machine learning for automatic gait detection in mice |
Amount | £2,800 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | DTP - D'Aout, Lakany, Macerollo - Remote gait evaluation for people with Parkinson's Disease |
Amount | £80,000 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Daroszewska, van t'Hof - Understanding the role of p62 deletion in Paget's disease of bone |
Amount | £46,359 (GBP) |
Organisation | Paget's Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2020 |
End | 07/2021 |
Description | Development of the UK study for the ESA FLUMIAS project: Mitochondrial hydrogen peroxide as a mediator of muscle loss under microgravity and ageing |
Amount | £272,402 (GBP) |
Funding ID | ST/X002160/1 |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 06/2022 |
End | 12/2024 |
Description | Dowager Countees Eleanor Peel Trust (Henstock) |
Amount | £13,500 (GBP) |
Organisation | The Dowager Countess Eleanor Peel Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Dunhill Medical Trust (Clegg, Screen, Thorpe) |
Amount | £250,000 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Dunhill Medical Trust (Whysall) |
Amount | £197,222 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | EU Funding Innovative Medicines Initiative |
Amount | € 12,000,000 (EUR) |
Organisation | European Commission |
Department | Innovative Medicines Initiative (IMI) |
Sector | Public |
Country | Belgium |
Start |
Description | EU Marie Curie (Bernut, Renshaw) |
Amount | £161,000 (GBP) |
Organisation | Marie Curie |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Eastell - Alexion module 2 further testing, project to support further research related to SHADES 2 grant |
Amount | £31,550 (GBP) |
Organisation | Alexion Pharmaceuticals |
Sector | Private |
Country | United States |
Start |
Description | Eastell - Gastrin receptor as a target for osteoporosis |
Amount | £30,000 (GBP) |
Organisation | CL Pharm |
Sector | Private |
Country | Korea, Republic of |
Start |
Description | Eastell - MicroRNA and bone health: prediction of fracture in older women; prediction of bone turnover in type I diabetes |
Amount | £26,528 (GBP) |
Organisation | Higher Education Funding Council for England |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 03/2022 |
Description | Eastell - Skeletal and Hypophosphataemic Events following Iron Infusion |
Amount | £45,000 (GBP) |
Organisation | Pharmacosmos A/S |
Sector | Private |
Country | Denmark |
Start | 02/2021 |
End | 07/2021 |
Description | Eastell, Fontalis - Osteoclast precursors in patients treated with denosumab |
Amount | £10,000 (GBP) |
Organisation | European Calcified Tissue Society (ECTS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2020 |
End | 08/2021 |
Description | Eastell- Clinical utility of PINP: the POSE Study |
Amount | £91,000 (GBP) |
Organisation | Roche Pharmaceuticals |
Sector | Private |
Country | Global |
Start |
Description | EcMagine': Extracellular Matrix ageing across the life course interdisciplinary research network |
Amount | £176,275 (GBP) |
Funding ID | BB/W018314/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2022 |
End | 02/2024 |
Description | Elucidating the mechanisms underlying glucose regulated autophagy in pancreatic beta-cells |
Amount | £100,000 (GBP) |
Organisation | European Association for the Study of Diabetes (EASD) |
Sector | Charity/Non Profit |
Country | Germany |
Start | 01/2023 |
End | 06/2024 |
Description | Environmental impact upon osteoarthritis risk during human skeletogenesis |
Amount | £29,510 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2023 |
End | 03/2024 |
Description | Evaluation of senolytic interventions in skin ageing |
Amount | £361,353 (GBP) |
Funding ID | BB/S006710/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2019 |
End | 01/2022 |
Description | Exploiting microvesicle small non-coding RNA and protein cargo in osteoarthritis for early diagnosis and treatment |
Amount | £272,093 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Exploiting microvesicle small non-coding RNA and protein cargo in osteoarthritis for early diagnosis and treatment' |
Amount | £272,000 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Exploiting microvesicle small non-coding RNA cargo in osteoarthritis for early diagnosis and treatment |
Amount | £272,094 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Extracellular vesicles as a treatment for osteoarthritis |
Amount | £177,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | FIDELIO |
Amount | £3,500,000 (GBP) |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start |
Description | Frontier Engineering: Progression Grant in Modelling complex and partially identified engineering problems. Application to the musculoskeletal system. |
Amount | £757,886 (GBP) |
Funding ID | EP/S032940/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2019 |
End | 08/2022 |
Description | Gastrin receptor as a target for osteoporosis (addendum) |
Amount | £120,000 (GBP) |
Organisation | CL Pharm |
Sector | Private |
Country | Korea, Republic of |
Start | 03/2024 |
End | 12/2024 |
Description | Gillen, Peffers, Archer - A pilot study to compare metabolic markers in biofluids, between surviving and non-surviving surgical colic patients' |
Amount | £10,000 (GBP) |
Organisation | Petplan Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2020 |
End | 01/2022 |
Description | HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE) |
Amount | £263,127 (GBP) |
Funding ID | BB/V019821/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 03/2024 |
Description | HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE) |
Amount | £267,412 (GBP) |
Funding ID | BB/V019821/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 04/2024 |
Description | Health Education England NE (Birrell) |
Amount | £49,500 (GBP) |
Organisation | Health Education England |
Sector | Public |
Country | United Kingdom |
Start |
Description | Healthspan screening in C. Elegans |
Amount | £30,000 (GBP) |
Organisation | European Commission |
Department | European Regional Development Fund (ERDF) |
Sector | Public |
Country | Belgium |
Start |
Description | Hedgehog signalling in ligamentocytes: the role of mechanical loading |
Amount | £10,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Hontoir, Peffers, Welting - Investigation of small non-coding RNA in ageing and osteoarthritis, in an ovine model: bringing fundamentals to a large animal model |
Amount | £213,186 (GBP) |
Organisation | Fonds de la Recherche Scientifique |
Sector | Public |
Country | Belgium |
Start | 08/2020 |
End | 09/2023 |
Description | How does ageing affect post-transcriptional gene regulation in articular cartilage? |
Amount | £238,786 (GBP) |
Funding ID | RPGF2002/217 |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2024 |
Description | Hydrogel-encapsulation for preservation of mitochondria |
Amount | £20,000 (GBP) |
Organisation | European Commission |
Department | European Regional Development Fund (ERDF) |
Sector | Public |
Country | Belgium |
Start |
Description | INSPIRE |
Amount | £10,000 (GBP) |
Organisation | Academy of Medical Sciences (AMS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Identification of cytokines that drive progression of fibrosis in Dupuytren's disease: therapeutic opportunities with biologics |
Amount | £177,383 (GBP) |
Funding ID | 21809 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2018 |
End | 07/2022 |
Description | Illix Ltd (Wright, Moots, Edwards) |
Amount | £55,994 (GBP) |
Organisation | Illix Ltd |
Sector | Private |
Country | United Kingdom |
Start |
Description | Improving osteoarthritis - Nestle collaboration |
Amount | £130,203 (GBP) |
Organisation | Nestlé (Global) |
Sector | Private |
Country | Switzerland |
Start | 07/2023 |
End | 05/2024 |
Description | In vivo thickness and dynamic behaviour of the heel fat pad during ageing: biomechanical and anthropological impact of footwear (DynPadAge) |
Amount | £398,528 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2023 |
End | 08/2025 |
Description | Innovate UK (Hill) |
Amount | £350,000 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start |
Description | Investigating the mechanisms and therapeutic potential of targeting circadian clocks in collagen VI myopathies |
Amount | £70,688 (GBP) |
Funding ID | 21GRO-PG12-0532 |
Organisation | Muscular Dystrophy UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2022 |
End | 07/2023 |
Description | Investigating the regulation and function of OA-susceptibility gene PIK3R1 isoforms |
Amount | £59,682 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2024 |
End | 07/2025 |
Description | Investigating the role of inflammageing in fracture repair. |
Amount | £399,735 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 02/2024 |
End | 01/2027 |
Description | Isanejad - Sarcopenia in Stroke |
Amount | £5,000 (GBP) |
Organisation | Centre for Integrated research into Musculoskeletal Ageing |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2023 |
End | 05/2023 |
Description | Isanejad - Testing and exploring the application of Ambient Assisted Living Technology prototype |
Amount | £9,000 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | JGW Patterson Foundation (Sorial/Loughlin/Deehan) |
Amount | £52,000 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Jackson - MicroAge II |
Amount | £1,421,000 (GBP) |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 02/2023 |
End | 02/2025 |
Description | Jackson, McArdle - Close regulation of peroxiredoxin oxidation is essential for maintenance of muscle mass and function in the elderly |
Amount | £482,609 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 12/2021 |
End | 11/2023 |
Description | Jackson, McArdle, Henstock, Hoettges - Microgravity as a model for accelerated skeletal muscle ageing (supplement) |
Amount | £22,000 (GBP) |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 01/2022 |
End | 02/2022 |
Description | Jackson, McArdle, Henstock, Hoettges, Jones - Mitochondria as a key regulator of muscle loss in microgravity and during ageing on earth (MicroAge II) - a feasibility study. |
Amount | £149,000 (GBP) |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 03/2021 |
Description | Jackson, McArdle, Henstock, Jones, Hoettges - Mitochondrial hydrogen peroxide as the mediator of skeletal muscle loss under microgravity and during ageing on earth. |
Amount | £100,059 (GBP) |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 03/2022 |
Description | Japan Partnering Award: The paraventricular nucleus of the hypothalamus; networks and mathematical models. |
Amount | £50,755 (GBP) |
Funding ID | BB/S020772/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2019 |
End | 06/2024 |
Description | KTP Senolytic drug development and Validation |
Amount | £180,643 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start |
Description | KTP award (Miwa/Zglinicki) |
Amount | £181,000 (GBP) |
Organisation | Knowledge Transfer Partnerships |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Linking epigenomics with cellular senescence to identify novel therapeutics for osteoarthritis |
Amount | £120,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2022 |
End | 08/2026 |
Description | Loughlin - Investigating the Epigenetics of Osteoarthritis Genetic Risk |
Amount | £100,000 (GGP) |
Organisation | The Ruth and Lionel Jacobson Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2021 |
End | 09/2024 |
Description | MICROAGE: Microgravity as a model for accelerated skeletal muscle ageing |
Amount | £1,207,908 (GBP) |
Funding ID | ST/S003061/1 |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 11/2018 |
End | 10/2022 |
Description | MRC (Renshaw et al) |
Amount | £686,584 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | MRC CiC - Alix, McCloskey, Paggiosi - Novel electrical impedance spectroscopy for neurological disorders |
Amount | £16,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | MRC CiC - Pratt, Anderson - Prioritising Pharmacodynamics Biomarkers of PIM Inhibition for Early Phase Repurposing Studies in Rheumatoid Arthritis. |
Amount | £72,767 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2020 |
End | 07/2021 |
Description | MRC Project grant (Renshaw) |
Amount | £691,917 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | MRC World Class Labs Capital Funding |
Amount | £83,448 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 03/2021 |
Description | MRC iCASE Studentships (Renshaw et al) |
Amount | £289,023 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | MRC/ARUK CMAR Studentship (Peffers, Jones) |
Amount | £120,000 (GBP) |
Organisation | Versus Arthritis |
Department | Arthritis Research UK Centre for Musculoskeletal Ageing Research |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Maestro Pro Multiwell microelectrode array for the University of Liverpool electrophysiology suite: Cell Physiology meets high throughput |
Amount | £310,572 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2023 |
End | 06/2024 |
Description | Mansour, Graham, Hallsworth, Birrell, Anstee et al - Evaluating the feasibility and acceptability of virtual group consultations (vGCs) for tertiary prevention in patients with non-alcoholic fatty liver disease (NAFLD) - a mixed-methods pilot study |
Amount | £51,511 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 01/2021 |
End | 06/2022 |
Description | Metabolic reprogramming of human neutrophils during inflammation |
Amount | £143,064 (GBP) |
Funding ID | 22193 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2023 |
Description | MiRNA regulation of Chondrocyte function |
Amount | £130,000 (GBP) |
Organisation | Horse Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Mir-199 inhibition to reduce musculoskeletal ageing |
Amount | £9,826 (GBP) |
Funding ID | Seedcorn2021 100249-CD1 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 03/2023 |
Description | Mitochondria as a key regulator of muscle loss in microgravity and during ageing on earth (MicroAge II) - a feasibility study |
Amount | £120,831 (GBP) |
Funding ID | ST/V003917/1 |
Organisation | Science and Technologies Facilities Council (STFC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 03/2021 |
Description | Miwa - Healthspan screening in C. Elegans ARROW Grant |
Amount | £30,000 (GBP) |
Organisation | European Commission |
Department | European Regional Development Fund (ERDF) |
Sector | Public |
Country | Belgium |
Start |
Description | Miwa - Hydrogel-encapsulation for preservation of mitochondria |
Amount | £20,000 (GBP) |
Organisation | European Commission |
Department | European Regional Development Fund (ERDF) |
Sector | Public |
Country | Belgium |
Start |
Description | Miwa, Maxwell, Hobson, Knight - Validation of in-vivo senescent cell imaging using the fluorine labelled ß-galactosidase substrate, PyGal |
Amount | £50,000 (GBP) |
Organisation | United Kingdom Research and Innovation |
Department | UK SPINE Knowledge Exchange |
Sector | Public |
Country | United Kingdom |
Start | 12/2021 |
End | 04/2022 |
Description | Molecular genetic and epigenetic analysis of the chromosome 4p16.3 osteoarthritis risk locus |
Amount | £48,722 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Multi-modal high resolution preclinical PET+SPECT+CT scanner |
Amount | £939,518 (GBP) |
Funding ID | 208389/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2018 |
End | 01/2024 |
Description | NC3R grant (Shanley) |
Amount | £389,043 (GBP) |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start |
Description | NIHR HTA (Meher, Hannan) |
Amount | £2,100,000 (GBP) |
Organisation | National Institute for Health Research |
Department | Health Technology Assessment Programme (HTA) |
Sector | Public |
Country | United Kingdom |
Start |
Description | NIHR In-Practice Fellowship 2023: Can Group Consultations Deliver Personlised Care? |
Amount | £127,090 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 08/2023 |
End | 08/2027 |
Description | NIHR Newc BRC Project Grant (Birrell) |
Amount | £60,824 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Neutrophil extracellular traps (NETs) as a therapeutic target for the treatment of auto-immune inflammatory disease |
Amount | £82,971 (GBP) |
Funding ID | 22925 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2022 |
End | 08/2023 |
Description | Newcastle Hospital Trust (Young, Loughlin) |
Amount | £44,000 (GBP) |
Organisation | Newcastle upon Tyne Hospitals NHS Foundation Trust |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Newcastle University Group Consultation Virtual Hub: Managing & Preventing Severe Disability Across the UK. |
Amount | £250,000 (GBP) |
Organisation | Sir Jules Thorn Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Nittobo Evaluation of assay (Eastell) |
Amount | £70,000 (GBP) |
Organisation | Nittobo |
Sector | Private |
Country | Japan |
Start |
Description | Optimising the functional potential of serpins to block cartilage breakdown: Implications for novel therapeutics for osteoarthritis |
Amount | £398,127 (GBP) |
Funding ID | 22418 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2020 |
End | 04/2025 |
Description | Overcoming the barriers to maximize the commercial potential for vitamin D enriched eggs |
Amount | £161,000 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start |
Description | PROvision of braces for Patients with knee OsteoArthritis (PROP OA): a randomised controlled trial |
Amount | £1,622,564 (GBP) |
Funding ID | HTA/16/160/03 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 08/2018 |
End | 11/2022 |
Description | Peckovic-Vaughan - Clocks and Exercise |
Amount | £25,000 (GBP) |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2021 |
End | 05/2022 |
Description | Peffers - Determining predictive metabolomic biomarkers for meniscal injuries in dogs with cranial cruciate ligament rupture using stifle joint synovial fluid |
Amount | £32,927 (GBP) |
Organisation | Petsavers Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Peffers - INSPIRE award |
Amount | £20,000 (GBP) |
Organisation | Academy of Medical Sciences (AMS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Peffers - Investigation of the structure and cargo of extracellular vesicles from mesenchymal stem cells used for treatment of osteoarthritis in horses |
Amount | £10,000 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Peffers -Exploring mechanisms of autologous biological therapies for tendon injury repair in the horse |
Amount | £264,725 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Peffers, Clark, Comerford, Pye - Patient involvement panel (PIP) - Horse owners, trainers, those involved in equestrian sport |
Amount | £1,200 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2021 |
End | 05/2021 |
Description | Peffers, Comerford - Determining predictive metabolomic biomarkers for meniscal injuries in dogs with cranial cruciate ligament rupture using stifle joint synovial fluid |
Amount | £32,927 (GBP) |
Organisation | Petsavers Charitable Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2020 |
End | 09/2021 |
Description | Pekovic-Vaughan - Exploring new avenues in breast caner research: redox and metabolic programming of cancer and associated adipose tissue (REFRAME) |
Amount | £21,514 (GBP) |
Organisation | Ministry of Interior of the Republic of Serbia |
Sector | Public |
Country | Serbia |
Start |
Description | Poulet - Developing a model of joint osteoarthropathy for the rare disease Alkaptonuria |
Amount | £82,446 (GBP) |
Organisation | Alkaptonuria Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2023 |
Description | Poulet - Mir-199 inhibition to reduce musculoskeletal ageing |
Amount | £4,913 (GBP) |
Organisation | Stoneygate Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Poulet - Understanding the contribution of the osteoblast lineage to cartilage and joint health |
Amount | £9,540 (GBP) |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Poulet, Whysall - Mir-199 inhibition to reduce musculoskeletal ageing |
Amount | £9,826 (GBP) |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2021 |
Description | Pratt, Anderson, Filby, Hilkens, Reynolds - A Pilot study to Resolve seronegative inflammatory arthritis by synovial deconstruction (RESONATE-Pilot) |
Amount | £62,867 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2021 |
End | 07/2022 |
Description | Pratt, Plummer, Anderson - Investigating Pathways to Immune-Mediated Pathology During Cancer Immunotherapy |
Amount | £134,695 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2023 |
Description | Precision pathobiology for disease models. |
Amount | € 998,627 (EUR) |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start |
Description | Preventing falls in older people by an innovative connected shoe: development & biomechanics study |
Amount | £74,567,600 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start |
Description | Preventing falls in older people by an innovative connected shoe: development & biomechanics study |
Amount | £575,432 (GBP) |
Funding ID | 104142 |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 02/2020 |
Description | Project MicroAge: A tissue engineered discovery platform for improving muscle responses to exercise in ageing and spaceflight |
Amount | £80,000 (GBP) |
Funding ID | 2601024 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2021 |
End | 03/2025 |
Description | Protein cargo in osteoarthritis for diagnosis and treatment |
Amount | £350,000 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2024 |
End | 12/2027 |
Description | RACE - Research into Inflammatory Arthritis Centre Versus Arthritis |
Amount | £1,999,997 (GBP) |
Funding ID | 22072 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2019 |
End | 03/2024 |
Description | Rapid integrated tendon repair system |
Amount | £98,866 (GBP) |
Funding ID | 22032 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2019 |
End | 08/2020 |
Description | Reilly - Development of a humanised 3D model for osteoporosis to replace ovariectomised animals |
Amount | £2,558 (GBP) |
Organisation | Animal Free Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2022 |
End | 08/2022 |
Description | Renshaw - Epigenetic control of neutrophil phenotype and function |
Amount | £9,640 (GBP) |
Organisation | Centre for Integrated research into Musculoskeletal Ageing |
Sector | Academic/University |
Country | United Kingdom |
Start | 03/2023 |
End | 05/2023 |
Description | Repeat physical traumas an initiator for motor neuron disease (MND): an insight from professional rugby |
Amount | £40,500 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2024 |
End | 09/2028 |
Description | Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology |
Amount | £90,000 (GBP) |
Funding ID | NC/V00199X/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 01/2024 |
Description | Rice - Genetic and epigenetic effects in development and disease of the human hip |
Amount | £509,485 (GBP) |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2021 |
End | 07/2026 |
Description | Role of fibrillin-1 in protecting against osteoarthritis |
Amount | £1,093,175 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2023 |
End | 06/2026 |
Description | Role(s) of Fibrillin-1 in post-traumatic osteoarthritis |
Amount | £58,622 (GBP) |
Funding ID | 22451 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2019 |
End | 09/2022 |
Description | Ross, Eastell - Licence arrangement for the delayed clearance of parathyroid hormone |
Amount | £240,000 (GBP) |
Organisation | Aeterna Zentaris |
Sector | Private |
Country | Canada |
Start | 03/2021 |
End | 02/2022 |
Description | Royal College Surgeons Edinburgh (Sorial/Loughlin) |
Amount | £60,000 (GBP) |
Organisation | The Royal College of Surgeons of Edinburgh |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Sarcoma UK (Peffers, Balaskas) |
Amount | £20,750 (GBP) |
Organisation | Sarcoma UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Shieh, Eastell - Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition |
Amount | £1,668,857 (GBP) |
Organisation | National Institutes of Health (NIH) |
Sector | Public |
Country | United States |
Start | 04/2020 |
End | 04/2025 |
Description | Sorial - CRISPR/Cas9 human stem-cell modulation for personalised arthritis therapeutics |
Amount | £70,733 (GBP) |
Organisation | Royal College of Surgeons of England |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Sorial - CRISPR/Cas9 human stem-cell modulation for personalised arthritis therapeutics |
Amount | £72,500 (GBP) |
Organisation | US-UK Fulbright Commission |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Staunton - DEVS Research Support bursary |
Amount | £1,978 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Staunton - ILCAMs Departmental Research Support Fund |
Amount | £2,000 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Staunton - PDRA/ECR bursary |
Amount | £5,000 (GBP) |
Organisation | Centre for Integrated research into Musculoskeletal Ageing |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Stem cells for osteoarthritis research |
Amount | £145,000 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2024 |
End | 09/2028 |
Description | TEAM study - Tissue and Explant Analysis of Medical Implant Failure |
Amount | £621,046 (GBP) |
Organisation | Newcastle upon Tyne Hospitals NHS Charity |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2024 |
End | 01/2026 |
Description | Targeting neuromuscular ageing using chrono-pharmacological approaches and novel retinoids |
Amount | £100,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2023 |
End | 09/2027 |
Description | Temporal fascia function during human growth: biomechanical modelling to predict the impact of surgical intervention |
Amount | £379,396 (GBP) |
Funding ID | BB/X006867/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2023 |
End | 03/2026 |
Description | Tew - Improving the annotation of genes across the equine genome |
Amount | £9,980 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Tew - Post transcriptional gene regulation in ageing cartilage |
Amount | £238,786 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Tew, Vasilaki - Support for five PhD Studentships in ageing research |
Amount | £200,000 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2024 |
Description | Turlo - Do platelet rich plasma (PRP) derived extracellular vesicles (Evs) contribute towards rescuing the inflammatory tendon phenotype? |
Amount | £9,200 (GBP) |
Organisation | Horserace Betting Levy Board |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Turlo - Engineering tendon tissue in vitro with platelet-rich plasma hydrogels |
Amount | £10,772 (GBP) |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | UK Space Agency MICROAGE (Jackson, McArdle, Henstock, Hoettges) |
Amount | £1,291,511 (GBP) |
Organisation | UK Space Agency |
Sector | Public |
Country | United Kingdom |
Start | 11/2018 |
End | 11/2021 |
Description | Understanding the mechanisms and therapeutic potential of targeting biological clocks in Systemic Sclerosis |
Amount | £22,998 (GBP) |
Funding ID | M709 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2017 |
End | 04/2022 |
Description | Uni of Georgia pump-priming award (Henstock) |
Amount | £1,000 (GBP) |
Organisation | University of Georgia |
Sector | Academic/University |
Country | United States |
Start |
Description | University of Liverpool (Pefers) |
Amount | £6,300 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start |
Description | Unravelling the genetic signals in osteoarthritis |
Amount | £64,899 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2024 |
End | 12/2024 |
Description | UoL DTP - Oldershaw - The immunomodulatory properties of limbal mesenchymal stem cells (MSC) - a novel cell source for the treatment of age-related macular degeneration (AMD) |
Amount | £84,000 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2025 |
Description | Using Capture C analysis and CRISPR-Cas9 mediated genomic editing to identify the target genes of OA-associated chondrogenic enhancers |
Amount | £62,179 (GBP) |
Organisation | The JGW Patterson Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Utility of PINP to monitor osteoporosis treatment in clinical practice by non-specialist practitioners, the POSE study (PINP and Osteoporosis in Sheffield Evaluation) |
Amount | £93,824 (GBP) |
Organisation | F. Hoffmann-La Roche AG |
Department | Roche Diagnostics |
Sector | Private |
Country | Global |
Start |
Description | Vasilaki - An interdisciplinary ageing alliance: cellular metabolism over a life-course in socioeconomic disadvantaged populations |
Amount | £8,231 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Vaughan - Circadian Rhythms in cardiovascular function - partially self-funded PhD studentship |
Amount | £70,000 (GBP) |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2022 |
End | 09/2025 |
Description | Vaughan - Circadian rhythms in neuromuscular function |
Amount | £180,000 (GBP) |
Organisation | Government of Libya |
Sector | Public |
Country | Libya |
Start | 08/2022 |
End | 09/2025 |
Description | Von Zglinicki - Pre-clinical validation of novel candidate senolytics |
Amount | £73,000 (GBP) |
Organisation | United Kingdom Research and Innovation |
Department | UK SPINE Knowledge Exchange |
Sector | Public |
Country | United Kingdom |
Start |
Description | Walking on ageing feet: heel impact and forefoot deformation throughout the life course. |
Amount | £42,761 (GBP) |
Organisation | University of Liverpool |
Sector | Academic/University |
Country | United Kingdom |
Start | 12/2023 |
End | 11/2026 |
Description | Wellcome Trust Summer Scholarship (Henstock) |
Amount | £2,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Whysall - Pre-clinical development of oxi-miR inhibitors for muscle wasting |
Amount | £604,672 (GBP) |
Organisation | Science Foundation Ireland (SFI) |
Sector | Charity/Non Profit |
Country | Ireland |
Start | 12/2020 |
End | 11/2023 |
Description | Whysall, McDonagh - Improving long-term patient recovery and reducing disability after COVID-19 critical illness using microRNA-based approaches |
Amount | £199,621 (GBP) |
Organisation | Health Research Board (HRB) |
Sector | Public |
Country | Ireland |
Start | 05/2020 |
End | 05/2022 |
Description | Wilkinson - A Randomized Clinical Trial of a Modular Cementless Acetabular Metal on Poly Component versus a Monoblock Cementless Titanium Shell with Ceramic on Ceramic Bearing and |
Amount | £42,689 (GBP) |
Organisation | University of Ottawa |
Department | Ottawa Health Research Institute |
Sector | Academic/University |
Country | Canada |
Start |
Description | Wilkinson - Functional genomics of osteoarthritis |
Amount | £146,312 (GBP) |
Organisation | Helmholtz Association of German Research Centres |
Department | Helmholtz Zentrum Munchen |
Sector | Academic/University |
Country | Germany |
Start |
Description | Wilkinson - MRC DiMeN DTP - Taking the bait - Exploiting new tools to capture, identify, visualise active proteinases in osteoarthritic cartilage destruction. |
Amount | £120,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2022 |
End | 09/2026 |
Description | Wilkinson - MRC IAA - Preclinical development of mesenchymal stem cell-based regenerative therapy for the treatment of human Osteoarthritis |
Amount | £75,000 (GBP) |
Organisation | University of Sheffield |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2023 |
End | 12/2023 |
Description | Wilkinson - OMOP mapping of the NJR dataset |
Amount | £70,000 (GBP) |
Organisation | Health Data Research UK |
Sector | Private |
Country | United Kingdom |
Start | 03/2023 |
End | 02/2024 |
Description | Wilkinson - Single-cell regulatory dynamics of the osteoarthritis knee joint |
Amount | £360,454 (GBP) |
Organisation | Technical University of Munich |
Sector | Academic/University |
Country | Germany |
Start | 05/2023 |
End | 05/2025 |
Description | Wilkinson - Using activity-based probes to capture active proteinases in the OA joint: new insights into active disease mechanisms |
Amount | £15,524 (GBP) |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Wilkinson, Peffers, Castenheira - Production of a patient/public leaflet to describe the biology of osteoarthritis |
Amount | £1,310 (GBP) |
Organisation | Centre for Integrated research into Musculoskeletal Ageing |
Sector | Academic/University |
Country | United Kingdom |
Start | 02/2021 |
End | 02/2022 |
Description | Wright - Neutrophil extracellular traps (NETs) as a therapeutic target for the treatment of auto-immune inflammatory disease |
Amount | £82,971 (GBP) |
Organisation | Lorna and Yuti Chernajovsky Biomedical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2022 |
End | 08/2023 |
Description | Yakomoto, Peffers, Jarad, van't Hof - Identifying age-related extracellular microenvironment in dental tissues |
Amount | £160,000 (GBP) |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2021 |
End | 09/2024 |
Description | Young investigator travel grant, ASBMR Annual Meeting, Orlando, Florida |
Amount | £0 (GBP) |
Organisation | American Society for Bone and Mineral Research |
Sector | Charity/Non Profit |
Country | United States |
Start | 08/2020 |
Description | do snoRNAs govern genotype-phenotype interactions in hypertrophic cardiomyopathy? |
Amount | £969,481 (GBP) |
Organisation | British Heart Foundation (BHF) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2023 |
End | 05/2027 |
Title | Fibrotic tissue and healthy ligament |
Description | Human tissue samples derived from surgery as well as cell cultures, tissue extracts and RNA/cDNA derived thereof. |
Type Of Material | Biological samples |
Year Produced | 2018 |
Provided To Others? | No |
Impact | Contributed to CIMA PhD completion and ongoing MRC and Versus Arthritis funded projects. |
Title | Model of age-related bone loss |
Description | Computational model to investigate age-related bone loss |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | This featured as "Model of the month" in Nov 2018 in Biomodels database |
Title | Pekovic-Vaughan - Clock luciferase reporter lung and intestinal cells |
Description | Cell line for reporting biological oscillations in real time in lung and intestinal cells. |
Type Of Material | Cell line |
Year Produced | 2023 |
Provided To Others? | No |
Impact | It will expand our ability to test time-of-day drugs and treatments in skeletal muscle cells and other cell types in vitro. |
Title | Pekovic-Vaughan - Clock luciferase reporter muscle cells |
Description | Clock luciferase reporter muscle cells used for reporting biological oscillations in real time. |
Type Of Material | Cell line |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | it will expand our ability to test time-of-day drugs and treatments in skeletal muscle cells ex vivo |
Title | characterisation of epigenomic changes during chondrogenesis |
Description | Computational model to investigate age-related changes in signalling pathways in OA |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | TBC |
Title | Characterisation of epigenomic changes during chondrogenesis |
Description | ChIP-seq data from MSC chondrogenesis |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | No |
Impact | Publication submitted |
Title | ESM Raw data from Skeletal muscle function underpins muscle spindle abundance |
Description | Muscle spindle abundance is highly variable within and across species, but we currently lack any clear picture of the mechanistic causes or consequences of this variation. Previous use of spindle abundance as a correlate for muscle function implies a mechanical underpinning to this variation, but these ideas have not been tested. Herein, we use integrated medical imaging and subject-specific musculoskeletal models to investigate the relationship between spindle abundance, muscle architecture and in vivo muscle behaviour in the human locomotor system. These analyses indicate that muscle spindle number is tightly correlated with muscle fascicle length, absolute fascicle length change, velocity of fibre lengthening and active muscle forces during walking. Novel correlations between functional indices and spindle abundance are also recovered, where muscles with a high abundance predominantly function as springs, compared to those with a lower abundance mostly functioning as brakes during walking. These data demonstrate that muscle fibre length, lengthening velocity and fibre force are key physiological signals to the central nervous system and its modulation of locomotion, and that muscle spindle abundance may be tightly correlated to how a muscle generates work. These insights may be combined with neuromechanics and robotic studies of motor control to help further tease apart the functional drivers of muscle spindle composition. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
URL | https://rs.figshare.com/articles/dataset/ESM_Raw_data_from_Skeletal_muscle_function_underpins_muscle... |
Title | ESM Raw data from Skeletal muscle function underpins muscle spindle abundance |
Description | Muscle spindle abundance is highly variable within and across species, but we currently lack any clear picture of the mechanistic causes or consequences of this variation. Previous use of spindle abundance as a correlate for muscle function implies a mechanical underpinning to this variation, but these ideas have not been tested. Herein, we use integrated medical imaging and subject-specific musculoskeletal models to investigate the relationship between spindle abundance, muscle architecture and in vivo muscle behaviour in the human locomotor system. These analyses indicate that muscle spindle number is tightly correlated with muscle fascicle length, absolute fascicle length change, velocity of fibre lengthening and active muscle forces during walking. Novel correlations between functional indices and spindle abundance are also recovered, where muscles with a high abundance predominantly function as springs, compared to those with a lower abundance mostly functioning as brakes during walking. These data demonstrate that muscle fibre length, lengthening velocity and fibre force are key physiological signals to the central nervous system and its modulation of locomotion, and that muscle spindle abundance may be tightly correlated to how a muscle generates work. These insights may be combined with neuromechanics and robotic studies of motor control to help further tease apart the functional drivers of muscle spindle composition. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
URL | https://rs.figshare.com/articles/dataset/ESM_Raw_data_from_Skeletal_muscle_function_underpins_muscle... |
Title | FRAX 2 dataset |
Description | Tool to develop an updated calculation engine for the FRAX tool |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | In process |
Title | McCloskey - FRAX 2 development |
Description | Collation of 64 international cohorts comprising approximately 2,000,000 persons and approximately 20 million person-years of observation. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
Impact | Paper describing the collection has been published (Vandenput et al, Osteoporos Int, 2022 , 33;2103-2136, DOI: 10.1007/s00198-022-06435-6). The future impact will be a complete update of the FRAX tool to include updated coefficients and additional risk factors. The more short term impact will be numerous meta-analyses of risk factors for fracture. |
URL | https://pubmed.ncbi.nlm.nih.gov/35639106/ |
Title | McCloskey - Update of FRAX dataset |
Description | Update of the fracture risk prediction tool FRAX: A systematic review of potential cohorts and analysis plan. Awaiting publication. |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | No |
Impact | No impact yet, due to be published 2022. |
Title | Pekovic-Vaughan - Mathematical model of clock oscillations |
Description | improved modelling clock oscillations from tissues |
Type Of Material | Computer model/algorithm |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | it will expand our ability to predict outcomes of time-of-day drug treatments, interventions and molecular pathway interactions |
Title | Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV |
Description | NET proteomics dataset |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | TBC |
Title | Spatio-Temporal Atlas of Bone Mineral Density Ageing |
Description | technique utilises an alternating minimisation technique to map the observed bone density measurements into a latent standardised space |
Type Of Material | Data analysis technique |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | Publication |
Title | Wilkinson, Farzi - Development of spatiotemporal map of bone ageing |
Description | ppixel based map of bone ageing in the proximal femur |
Type Of Material | Computer model/algorithm |
Year Produced | 2022 |
Provided To Others? | No |
Impact | no impacts |
Title | Wright - Changes in neutrophil gene expression in psoriatic arthritis patients in response to sekukinumab |
Description | Changes in gene expression in human peripheral blood neutrophils from patients with psoriatic arthritis (PsA) before and 12-weeks after treatment with Secukinumab (SKB, 150mg). NCBI GEO dataset GSE179800 |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | No impact yet |
URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179800 |
Title | Wright - Changes in neutrophil gene expression in psoriatic arthritis patients in response to sekukinumab |
Description | NCBI GEO dataset GSE179800 |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | Publication https://doi.org/10.1093/rheumatology/kead007 |
URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179800 |
Title | Wright - Metabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition. |
Description | Metabolic Profiling of Rheumatoid Arthritis Neutrophils following treatment with JAK inhibitors - MetaboLights dataset MTBLS4766 |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
Impact | Multiple citations of manuscript. |
URL | https://www.mdpi.com/2218-1989/12/7/650 |
Title | Wright - Metabolic profiling of rheumatoid arthritis neutrophils revels altered energy metabolism that is not affected by JAK inhibition |
Description | MetaboLights dataset MTBLS4766 (under deposition) |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | Publication https://doi.org/10.3390/metabo12070650 |
Description | Birrell - BSLM Virtual Group Consultations Webinars: Continuity of Care During Covid |
Organisation | British Society of Lifestyle Medicine |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Led by Fraser Birrell |
Collaborator Contribution | Rotation of chairs from UK, USA, Australia. International panel of experts. Sharing videos of webinars on websites, supporting spread & data sharing. |
Impact | Paper published; Multidisciplinary, including all clinical groups, management, indutry, education, research |
Start Year | 2020 |
Description | Birrell - Group Consultation Collaboration |
Organisation | Deakin University |
Country | Australia |
Sector | Academic/University |
PI Contribution | International leadership in the group consultation field |
Collaborator Contribution | Authority on renal disease and patient partnership in an Australian context |
Impact | Application for funding for AUS$2,499,263 |
Start Year | 2022 |
Description | Birrell - Informing long-term conditions policy with virtual group consultations |
Organisation | British Society of Lifestyle Medicine |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Initiated and led by Fraser Birrell |
Collaborator Contribution | International policy collaboration, sharing and knowledge exchange. |
Impact | No output yet. Multidisciplinary, including all clinical groups, lifestyle organisations, education, research |
Start Year | 2021 |
Description | Birrell - Informing long-term conditions policy with virtual group consultations |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Initiated and led by Fraser Birrell |
Collaborator Contribution | International policy collaboration, sharing and knowledge exchange. |
Impact | No output yet. Multidisciplinary, including all clinical groups, lifestyle organisations, education, research |
Start Year | 2021 |
Description | Birrell - Informing long-term conditions policy with virtual group consultations |
Organisation | NHS England |
Country | United Kingdom |
Sector | Public |
PI Contribution | Initiated and led by Fraser Birrell |
Collaborator Contribution | International policy collaboration, sharing and knowledge exchange. |
Impact | No output yet. Multidisciplinary, including all clinical groups, lifestyle organisations, education, research |
Start Year | 2021 |
Description | Birrell - Informing long-term conditions policy with virtual group consultations |
Organisation | Southern Cross University |
Country | Australia |
Sector | Academic/University |
PI Contribution | Initiated and led by Fraser Birrell |
Collaborator Contribution | International policy collaboration, sharing and knowledge exchange. |
Impact | No output yet. Multidisciplinary, including all clinical groups, lifestyle organisations, education, research |
Start Year | 2021 |
Description | Birrell - Informing long-term conditions policy with virtual group consultations |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Initiated and led by Fraser Birrell |
Collaborator Contribution | International policy collaboration, sharing and knowledge exchange. |
Impact | No output yet. Multidisciplinary, including all clinical groups, lifestyle organisations, education, research |
Start Year | 2021 |
Description | D'Aout - HOGent Belgium |
Organisation | University College Ghent |
Country | Belgium |
Sector | Academic/University |
PI Contribution | Co-investigator on MRC-funded grant |
Collaborator Contribution | Field expertise and access to native populations |
Impact | Biomechanics and anthropology |
Start Year | 2023 |
Description | D'Aout - Heel pad mechanics |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Established the partnership, will co-supervise PhD student |
Collaborator Contribution | Will co-supervise PhD student |
Impact | PhD studentship |
Start Year | 2023 |
Description | D'Aout - Heel pad mechanics |
Organisation | VivoBarefoot Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Established the partnership |
Collaborator Contribution | Provided funding for a PhD studentship |
Impact | PhD studentship |
Start Year | 2023 |
Description | F Birrell - Group consultations to promote personalised care, self-management and shared decision making |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Group consultation blog for Personalised Care Institute |
Collaborator Contribution | Input from self-care academic research unit at Imperial College London and Personalised Care Institute |
Impact | Support for in practice fellowship and group consultation for Personalised Care Institute website |
Start Year | 2024 |
Description | Hill - Newcastle collaboration TULIPS (Towards and Understanding of Life and Living on Old Age) consortium |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Data analysis of oldest old databases, publications |
Collaborator Contribution | Joint data analysis nd publications |
Impact | Collaborative meetings in Auckland (2018) and Tokyo (2019), papers in preparation for submission. |
Start Year | 2018 |
Description | IOFIFCC Working group |
Organisation | International Osteoporosis Foundation |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | Bone turnover markers, collab to produce guidelines on the use of markers |
Collaborator Contribution | As above |
Impact | As above |
Start Year | 2018 |
Description | Isanejad - Muscle biopsy metabolomics |
Organisation | McMaster University |
Country | Canada |
Sector | Academic/University |
PI Contribution | Sample processing and data analysis |
Collaborator Contribution | Muscle biopsy samples |
Impact | Manuscript in preparation |
Start Year | 2023 |
Description | Jackson - MicroAge projects |
Organisation | Kayser Space |
Country | United Kingdom |
Sector | Private |
PI Contribution | Scientific expertise and questions |
Collaborator Contribution | Hardware design and manufacture |
Impact | Successful mission to the ISS |
Start Year | 2018 |
Description | McCloskey - Amgen/UCSF CrystalBone - Predicting Short-term Fracture Risk with Deep Learning |
Organisation | Amgen Inc |
Country | United States |
Sector | Private |
PI Contribution | Research design advice, data interpretation and manuscript writing |
Collaborator Contribution | Research design and conduct, data interpretation and manuscript writing |
Impact | Not yet |
Start Year | 2019 |
Description | McCloskey - McGill gSOS - development and clinical utility of a polygenic score for a measure of bone mass |
Organisation | McGill University |
Country | Canada |
Sector | Academic/University |
PI Contribution | Assessing fracture risk by FRAX in cohorts used in discovery and validation testing of gSOS; contribution to data interpretation and report/manuscript writing |
Collaborator Contribution | Developing and validating the gSOS polygenic score. Contribution to data interpretation and report/manuscript writing |
Impact | https://doi.org/10.1101/413716 |
Start Year | 2017 |
Description | McCloskey - UKRI MRC National Musculoskeletal Ageing Network |
Organisation | University of Bristol |
Department | Musculoskeletal Research Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Established the partnership ad contributed to its mission |
Collaborator Contribution | Established the partnership ad contributed to its mission |
Impact | Publication of current landscape and research priorities fundamental to achieving healthy musculoskeletal ageing |
Start Year | 2022 |
Description | McCloskey - UKRI MRC National Musculoskeletal Ageing Network |
Organisation | University of Southampton |
Department | MRC Lifecourse Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Established the partnership ad contributed to its mission |
Collaborator Contribution | Established the partnership ad contributed to its mission |
Impact | Publication of current landscape and research priorities fundamental to achieving healthy musculoskeletal ageing |
Start Year | 2022 |
Description | McCloskey - UKRI MRC National Musculoskeletal Ageing Network |
Organisation | Versus Arthritis |
Department | Arthritis Research UK Centre for Musculoskeletal Ageing Research |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Established the partnership ad contributed to its mission |
Collaborator Contribution | Established the partnership ad contributed to its mission |
Impact | Publication of current landscape and research priorities fundamental to achieving healthy musculoskeletal ageing |
Start Year | 2022 |
Description | Oldershaw and McArdle - BBSRC-UoL International Collaboration Funding: Accelerated disruption of the neuromuscular junction (NMJ) in microgravity: a model for muscle ageing |
Organisation | University of Michigan |
Department | Molecular & Integrative Physiology |
Country | United States |
Sector | Academic/University |
PI Contribution | RO: development of protocol for the directed differentiation of human IPSCs to motor neuron, which with AM (UoL) will be combined with human muscle cells to develop a model of the neuro-muscular junction, allowing for the investigation of molecular and celular events that take place during ageing. |
Collaborator Contribution | The partners at Michigan have expertise in co-culture of non-human muscle and neuron cells to form the NMJ. The collaboration shares expertise that will used used to advance to a humanised model. |
Impact | No output yet |
Start Year | 2023 |
Description | Pease - Computational modelling of kidney fibrosis |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Supervised a post-doc to analyse data and generate a computational model to study the cross talk between angiotensin and inflammatory signalling in kidney fibrosis |
Collaborator Contribution | Data were generated in the lab of Dr Kathryn Garner to inform the computational model. |
Impact | £44,000 Kidney Research UK grant funded. Manuscript in preparation. Multidisciplinary - cell culture, bioinformatics, and computational modelling. |
Start Year | 2020 |
Description | Pease - Computational modelling of kidney fibrosis |
Organisation | Northumbria University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Supervised a post-doc to analyse data and generate a computational model to study the cross talk between angiotensin and inflammatory signalling in kidney fibrosis |
Collaborator Contribution | Data were generated in the lab of Dr Kathryn Garner to inform the computational model. |
Impact | £44,000 Kidney Research UK grant funded. Manuscript in preparation. Multidisciplinary - cell culture, bioinformatics, and computational modelling. |
Start Year | 2020 |
Description | Pekovic-Vaughn - Liverpool collaboration Mathematical modelling of non-canonical NRF2 role in circadian clock regulation |
Organisation | University of Liverpool |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | provided experimental data from various musculoskeletal tissues around the clock |
Collaborator Contribution | provided experimental data from various musculoskeletal tissues around the clock |
Impact | two papers in preparation |
Start Year | 2019 |
Description | Poulet - Florida Atlantic University New MMP13 inhibitor against osteoarthritis |
Organisation | Florida Atlantic University |
Country | United States |
Sector | Academic/University |
PI Contribution | We performed the study and analysis (involving mouse osteoarthritis induction, treatment, tissue collection and analysis). |
Collaborator Contribution | supply of treatment and expertise on kinetics of the drug. Will also analyse the serum from these mice for in vivo kinetics of the treatment. |
Impact | tbc (expected publication and future grant applications); collaboration between Biomedical scientist (mouse models of disease) and biochemist. |
Start Year | 2019 |
Description | Rice - Nuchido Senescence |
Organisation | Nuchido |
Sector | Private |
PI Contribution | Supervision of PhD student, lead on publications and experimental design |
Collaborator Contribution | Co-funded an EPSRC studentship, provided molecules for testing under an NDA |
Impact | PhD studentship |
Start Year | 2023 |
Description | Schini - FRAX tool |
Organisation | Australian Catholic University |
Country | Australia |
Sector | Academic/University |
PI Contribution | Work to improve the FRAX tool and produce publications |
Collaborator Contribution | Work to improve the FRAX tool and produce publications |
Impact | Manuscript on Parkinson's disease |
Start Year | 2022 |
Description | Schini - FRAX tool |
Organisation | University of Sheffield |
Department | WHO Collaborating Centre for Metabolic Bone Diseases |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Work to improve the FRAX tool and produce publications |
Collaborator Contribution | Work to improve the FRAX tool and produce publications |
Impact | Manuscript on Parkinson's disease |
Start Year | 2022 |
Description | Schini - FRAX tool |
Organisation | University of Southampton |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Work to improve the FRAX tool and produce publications |
Collaborator Contribution | Work to improve the FRAX tool and produce publications |
Impact | Manuscript on Parkinson's disease |
Start Year | 2022 |
Description | Schini - Phase II study of the impact of AZD4017, a selective 11ß-HSD1 inhibitor, on biochemical markers of bone turnover in post-menopausal osteopenia (The STAG study) |
Organisation | University of Leeds |
Department | Leeds School of Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Writing up results of study |
Collaborator Contribution | Writing up results of study |
Impact | Manuscript will be published once written |
Start Year | 2020 |
Description | Schini - Reference interval for albumin-adjusted calcium based on a large UK population |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analysis, interpretation and write up |
Collaborator Contribution | Interpretation and write up |
Impact | Manuscript published |
Start Year | 2019 |
Description | Schini - SABRE study |
Organisation | University of California, San Francisco |
Department | School of Medicine (UCSF) |
Country | United States |
Sector | Academic/University |
PI Contribution | Collaboration to write the FDA report to allow BMD to be a surrogate marker for osteoporosis trials |
Collaborator Contribution | Collaboration to write the FDA report to allow BMD to be a surrogate marker for osteoporosis trials |
Impact | FDA report and articles pending |
Start Year | 2022 |
Description | Staunton - Richard Robitaille |
Organisation | University of Montreal |
Country | Canada |
Sector | Academic/University |
PI Contribution | Knowledge and collaboration |
Collaborator Contribution | Knowledge and collaboration |
Impact | Sponsored Dunhill Medical Trust fellowship application (outcome pending) and tenure-track fellowship (awarded) |
Start Year | 2023 |
Description | Staunton - Roslyn Bill |
Organisation | Aston University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Knowledge and collaboration |
Collaborator Contribution | Knowledge and collaboration |
Impact | Supported Dunhill Medical Trust fellowship (outcome pending) and tenure-track fellowship (awarded) |
Start Year | 2023 |
Description | Vaughan - BBSRC-funded ECMage network |
Organisation | United Kingdom Research and Innovation |
Country | United Kingdom |
Sector | Public |
PI Contribution | resources/data/expertise |
Collaborator Contribution | resources/in kind contribution |
Impact | Further funding application to extend the network life and joint research collaborations. Maths, molecular biology, biochemistry, tissue engineering, mechano biology, chronobiology |
Start Year | 2022 |
Description | Vaughan - REFRAME redox-metabolic network |
Organisation | University of Belgrade |
Country | Serbia |
Sector | Academic/University |
PI Contribution | resources/data/expertise |
Collaborator Contribution | resources/in kind contribution |
Impact | Articles, summer exchange visits. Biochemistry, chronobiology, bioinformatics, moelcular biology |
Start Year | 2022 |
Description | Wilkinson - SerpinTrap peptides in OA models |
Organisation | Apex Molecular |
Country | United Kingdom |
Sector | Private |
PI Contribution | Concept of compound, computational biology data, acquisition of pilot funding |
Collaborator Contribution | Synthesis of proof of principle compound |
Impact | Successful award of Impact Accelerator Account (IAA) approx. £50k. Chemistry, Biology and Veterinary surgery. |
Start Year | 2022 |
Description | Wilkinson - Synthesis of a proof of principle compound |
Organisation | Apex Molecular |
Country | United Kingdom |
Sector | Private |
PI Contribution | Idea for the compound, guided the requirements for testing |
Collaborator Contribution | Expertise in chemical synthesis |
Impact | None yet, but compound has recently been delivered to UoL for testing. If successful we will seek further funding to develop a compound library (potential future co-application with Apex). |
Start Year | 2022 |
Description | Wilkinson - University of Manchester |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Tissue culture and in vitro differentiation |
Collaborator Contribution | Generation of stable cell lines |
Impact | Collaboration in progress - Cell and molecular biology, gene editing, CRISPR, stem cells, osteoblast and chondrocyte differentiation |
Start Year | 2021 |
Description | Wright - CIMA MRes project |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Transcriptomics analysis |
Collaborator Contribution | Data |
Impact | not yet |
Start Year | 2021 |
Description | Wright - CRISPR in model organisms |
Organisation | Newcastle University |
Department | Newcastle University Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Neutrophil expertise, provision of human samples |
Collaborator Contribution | Expertise in CRISPR and model organisms |
Impact | BBSRC DTP PhD project (shortlisting) |
Start Year | 2023 |
Description | Wright - Clinical Rheumatology |
Organisation | Liverpool University Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Neutrophil expertise, analysis of human samples |
Collaborator Contribution | Provision of clinical samples |
Impact | Connect Immune grant funding |
Start Year | 2022 |
Description | Wright - Clinical Rheumatology |
Organisation | University of Birmingham |
Department | Institute of Inflammation and Ageing |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Neutrophil expertise, sample analysis |
Collaborator Contribution | Provision of clinical samples (anticipated) |
Impact | Versus Arthritis grant application (under review) |
Start Year | 2022 |
Description | Wright - Kinase Biology |
Organisation | University of Liverpool |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Neutrophil expertise, provision of human samples |
Collaborator Contribution | Expertise in kinase inhibition |
Impact | Connect immune grant funding |
Start Year | 2022 |
Description | Wright - MS Metabolomics |
Organisation | University of Liverpool |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Neutrophil expertise, provision of human samples |
Collaborator Contribution | Expertise in MS analysis and data analysis |
Impact | Versus Arthritis grant application (under review) |
Start Year | 2022 |
Description | Wright - MS Phosphoproteomics |
Organisation | University of Liverpool |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Neutrophil expertise, provision of human samples |
Collaborator Contribution | Expertise in MS phosphoproteomics |
Impact | BBSRC DTP PhD project (shortlisting) |
Start Year | 2023 |
Description | Wright - Neutrophil migration assays |
Organisation | Harvard University |
Country | United States |
Sector | Academic/University |
PI Contribution | Neutrophil expertise, provision and analysis of human samples |
Collaborator Contribution | Provision of microfluidics chambers |
Impact | Dunhill medical trust grant application (under review) |
Start Year | 2023 |
Description | Wright - New Amsterdam Sciences |
Organisation | New Amsterdam Sciences |
Country | United States |
Sector | Private |
PI Contribution | Pilot experiments in neutrophils to determine effect of novel drug |
Collaborator Contribution | Provision of drug |
Impact | No impact yet |
Start Year | 2021 |
Description | Wright - Zebrafish in vivo models of ageing |
Organisation | University of Bristol |
Department | School of Physiology, Pharmacology and Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Optimisation of co-culture assays and provision of clinical samples |
Collaborator Contribution | Provision of zebrafish scales for co-culture assays |
Impact | Dunhill medical trust grant application (under review) |
Start Year | 2023 |
Description | Wright- Ogbechi transcriptomics |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Transcriptomics analysis |
Collaborator Contribution | Data |
Impact | not yet |
Start Year | 2020 |
Title | SENOLYTIC COMPOUNDS AND COMPOSITIONS |
Description | A combination with a mitochondrial uncoupler enhances the potency of senolytic drugs, especially BCL2 family-targeting drugs by orders of magnitude |
IP Reference | EP4210656 |
Protection | Patent / Patent application |
Year Protection Granted | 2023 |
Licensed | No |
Impact | No impact yet |
Title | Birrell - PROP OA Trial |
Description | NIHR HTA funded clinical trial |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2022 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Final report due 2024 |
Title | Eastell - Clinical Trial (OZPO) of netazepine. |
Description | Netazepine is a gastrin receptor antagonist in phase 2 trials funded by CL Bio |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2024 |
Development Status | Under active development/distribution |
Impact | No impact yet |
Title | Eastell - Prevention of osteoporosis using selenium |
Description | Selenium as a therapeutic intervention to prevent osteoporosis |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2022 |
Development Status | On hold |
Clinical Trial? | Yes |
Impact | Publication (DOI: 10.1002/jbmr.470). |
URL | https://pubmed.ncbi.nlm.nih.gov/36093566/ |
Title | Eastell - prevention of GIO using 11-beta HSD inhibitor |
Description | Prevention of glucocorticoid-induced osteoarthritis |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2023 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Publication (DOI: 10.1038/s41467-023-36541-w) |
URL | https://pubmed.ncbi.nlm.nih.gov/36823106/ |
Title | Eastell - prevention of osteoporosis using anti-resorptives in DM |
Description | Use of antiresorptives in DM to prevent osteoporosis - population-based cohort study using data from the Clinical Practice Research Datalink (CPRD) GOLD |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2022 |
Development Status | Under active development/distribution |
Impact | Publication (DOI: 10.1016/j.diabres.2022.109993) |
URL | https://pubmed.ncbi.nlm.nih.gov/35842030/ |
Title | Eastell - prevention of osteoporosis using vitamin D in pregnant mothers |
Description | Using vitamin D in pregnant mothers to prevent osteoporosis |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2022 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Publication (doi: 10.1002/jbm4.10651) |
URL | https://pubmed.ncbi.nlm.nih.gov/35866154/ |
Title | HPpQCT heel assessment |
Description | Protocol for scanning and analysing heel scans |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2018 |
Development Status | On hold |
Impact | Two publications |
Title | Happy Egg with added vitamin D |
Description | A vitamin D enriched egg product which was developed as a result of an Innovate funded project in 2015 Led to an additional Innovate UK funded project to explore the wider commercial potential for vitamin D enriched eggs |
Type | Preventative Intervention - Nutrition and Chemoprevention |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2018 |
Development Status | Closed |
Impact | See above |
Title | Novel anti-inflammatory compounds |
Description | Compounds originally developed in van 't Hof lab, now licensed to Modern Biosciences and Johnson & Johnson. advised on clinical trials |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2019 |
Development Status | Under active development/distribution |
Impact | TBC |
Title | Oldershaw - Clinical Trial Investigating inline dynamometry as a substitute for isometric electromechanical dynamometry for testing quadriceps strength in healthy and ACL-reconstructed individuals |
Description | Our research has shown that inline dynamometry is comparable to ED for measuring quadricep strength and so adoption of the inline device into clinical practice will enable patients to be correctly placed onto rehabilitation pathways that improve clinical outcomes and provide cost savings to the NHS by reducing longer term consequences of injury and further surgical interventions. |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Small-scale adoption |
Year Development Stage Completed | 2023 |
Development Status | Actively seeking support |
Clinical Trial? | Yes |
Impact | Device has been adopted into clinic in Liverpool Hospitals we are currently working with the manufacturer of the device to develop improvements for next generation and also monitor adoption more widely |
Title | Pekovic-Vaughan - Chrono-therapy for smarter use of retinoids |
Description | novel synthetic retinoids currently tested in preclinical models, to start clinical trials in 2024 |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2022 |
Development Status | Under active development/distribution |
Impact | this is a lead Nevrargenics product for the treatment of neurodegenerative and neuromuscular disorders-it will improve the company's delivery of the product for many people with said disorders |
URL | https://nevrargenics.com/ |
Title | Schini - Effect of AZD4017, a Selective 11ß-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia |
Description | No effect, no further development |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2022 |
Development Status | Closed |
Clinical Trial? | Yes |
Impact | Publication (doi: 10.1210/clinem/dgac100) |
URL | https://pubmed.ncbi.nlm.nih.gov/35275196/ |
Title | Schini - Utility of PINP to monitor osteoporosis treatment in primary care, the POSE study (PINP and Osteoporosis in Sheffield Evaluation) |
Description | This was a real world study to examine the cost effectiveness of using PINP in monitoring treatment for osteoporosis |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2022 |
Development Status | On hold |
Impact | Publication (doi: 10.1016/j.bone.2022.116347) |
URL | https://pubmed.ncbi.nlm.nih.gov/35134571/ |
Title | McCloskey - FRAX |
Description | Permits user to calculate individual's 10 year fracture probability (age 40-90 years) |
Type Of Technology | Webtool/Application |
Year Produced | 2008 |
Impact | Several hundred publication, incorporation into over 100 guidelines for osteoporosis management worldwide |
URL | https://frax.shef.ac.uk/FRAX/ |
Title | McCloskey - FRAXplus |
Description | Provides free access to FRAX and certain aspects of FRAXplus (e.g. registered accounts, database etc) plus optional fee-based access to FRAXplus adjustments of FRAX probabilities |
Type Of Technology | Webtool/Application |
Year Produced | 2023 |
Impact | No impacts yet |
URL | http://www.fraxplus.org |
Description | "Gene Editing: The Good, The Bad, and The Ugly" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Main purpose of activity: to share information and stimulate thinking and discussion. Results of the activity: planned for January 2022 |
Year(s) Of Engagement Activity | 2022 |
Description | BLSM hybrid annual meeting: Edinbrugh International Convention Centre & online |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Main purpose of activity: to share information, stimulate and inspire. Results of activity: Inspirational event both attended by patients and affecting many patients through the attendance of over 800 clinicians. Impact: Mean quality rating 4.46/5 99% well-organised/very well-organised. Free-text feedback was informative with 'inspiring'/inspirational' and 'uplifting' key themes. We welcomed the complaint: 'I have never seen so many bikes outside a conference venue'. |
Year(s) Of Engagement Activity | 2021 |
Description | Better Together: The Evidence Behind the Headlines A Group Consultation Public Engagement Event on Care and Research |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | An opportunity to ask health related questions, experience how a group consultation works and hear talks from experts in muskuloskeletal research. 25 attending; estimate 500 online Highly interactive session with questions from every attendeee. Excellent feedback from speakers and patients Enthusiasm for similar event at national CIMA meeting |
Year(s) Of Engagement Activity | 2019 |
Description | Birrell - British Society of Lifestyle Medicine Annual Meeting 2022 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Showcase the latest science and benefits of Lifestyle Medicine. Vibrant international conference- hosting European Lifestyle Medicine Council Impact - "98.6% rated 'well-organised' or 'very well-organised'. a. Wonderful venue. b. From THS staff - BSLM were fun, "non=boring", interesting, engaging, great conference. c. Great effort by BSLM, and a great marketing tool. Polite and friendly delegates. great mix of activities; yoga, running, sightseeing, art d. Great to involve local community - Tottenham GP, Community team, were fantastic e. Food was incredible f. Balance of speakers vs Q&A very good i.e., 3 talks then Q&A g. Balance of number of presentations great; wasn't overwhelming (unlike RCGP conference which was crazy) h. Conference app Q&A worked well i. Ticket sales, hit target. j. Health inequalities focus good. k. Involvement of grass roots clinicians v academics v policy makers v personalities was perfect. l. Sponsor involvement and feedback very positive - increased footfall and engagement." |
Year(s) Of Engagement Activity | 2022 |
Description | Birrell - British Society of Lifestyle Medicine Annual Meeting 2023 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Annual meeting to showcase the latest science and benefits of lifestyle medicine - 1067 delegates including 62 patients. Feedback was overall positive - 4.5 star average, 94% felt engaged throughout the full 3 days and 99% of delegates felt more inspired and equipped to be able to utilise lifestyle medicine. |
Year(s) Of Engagement Activity | 2023 |
Description | Birrell - DoubleDay General Medical Council meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Discussed national standards for patients as educators, mandating patients on quality panels and embedding Lifestyle Medicine/WHO core principles in Medical School curricula to ensure GMC is engaged in patient partnerships. Will be progressed in discussions at future meetings. |
Year(s) Of Engagement Activity | 2023 |
Description | Birrell - Doubleday Patient Partnership Prize-giving Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Undergraduate students |
Results and Impact | Royal Society of Medicine meeting - medical students who won the Doubleday Patient Partnership prize gave presentations. Excellent feedback from attendees. |
Year(s) Of Engagement Activity | 2023 |
Description | Birrell - Learning together - patient partnership event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Share and enhance patient partnership in education. Award Doubleday Student Essay prize (Natasha Treagust). Wonderful presentations from stellar international speakers: Prof Sir Michael Marmot, Prof Dame Clare Gerada, Dame Philippa Russell, Rachel Power, Sarah Tilsed Impact - Excellent feedback- opportunity to share content at subsequent patient events below. |
Year(s) Of Engagement Activity | 2022 |
Description | Birrell - Patients as educators events |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Re-engage patients involved in undergraduate education at Northumbria Healthcare. Wonderful , energising interactive sessions. Impact - Excellent feedback |
Year(s) Of Engagement Activity | 2022,2023 |
Description | Birrell - Virtual Group Consultations webinars: continuity of care during Covid |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Share experience of virtual group consultations. Effective benchmarking and sharing good practice. Impact - Excellent feedback with material effect on changing practice. 116 of the 718 registering for the first webinar had already conducted virtual group consultations so this empowered a step change in practice, >5,000 views of videos on catch-up, all available at https://bslm.org.uk/vgc/ |
Year(s) Of Engagement Activity | 2020,2021,2022 |
Description | CIMA patient engagement session |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Main purpose of activity: To share information. Results of activity: 2 presentations with plenty of time for Q&A, really interactive audience. |
Year(s) Of Engagement Activity | 2021 |
Description | Castanheira, Wright, Wilkinson and Peffers - Working group with patient partners |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | To develop a 'Behind rheumatoid arthritis' booklet. Co-production with patient partners of a leaflet called 'Behind rheumatoid arthritis' to explain the biology of rheumatoid arthritis Impact - None yet but will increase awareness and underrstanding of RA by a lay audience in the long term |
Year(s) Of Engagement Activity | 2022,2023 |
Description | D'Aout - PPI for UKRI application |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Discussed a UKRI grant application with a PPI group |
Year(s) Of Engagement Activity | 2023 |
Description | Dupuytren's PPI panel |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Patients heard about, provided feedback on and discussed current research, and were given tours of the laboratories. Contacts made with new surgical team via patient society, resulting in additional site being added to the study. Patients were keen to return to the next panel meeting. Researchers asked to contribute to webinar for patients. |
Year(s) Of Engagement Activity | 2019 |
Description | Dupuytren's patient involvement panel events |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | To discuss research findings and future plans and obtain patient perspectives on translation of results to treatment options as well as the wider environment influencing patient experience. The activities comprised patient involvement panel events lasting 3-4 hours and held in our research building. 6-12 patients or carers were present at each event. The president of the British Dupuytren's Society was also present, providing valuable relevant current information on clinical treatment options, research topics, broader patient perspectives and recent developments in the area. The events included an introduction to the research topic/history, presentation/discussion of research findings, discussion of preferred treatment options, and paper patient and feedback surveys. After each event participants were offered a laboratory tour which was taken up at least once by all participants and sparked additional discussions. |
Year(s) Of Engagement Activity | 2018,2019,2020 |
Description | Dupuytren's research webinar |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | To communicate current Dupuytren's research in the UK to patients ; The activity was participation in a research webinar organised by the British Dupuytren's Society. This involved a presentation broadcast to those registered for the webinar, along with presentations from 3 other research teams. The webinar was recorded and uploaded to YouTube. The estimate of the number of people reached was based on the number dialing in to the webinar plus the number of views on YouTube as of 21st April 2020. Dr Elizabeth Laird and Dr Emma Beamish gave the presentation. |
Year(s) Of Engagement Activity | 2019 |
Description | Exercise and nutrition for healthy ageing workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | share information and improve understanding ; "older adults from the local community came to talk by E Stevenson and Ellie Hayes (CIMA PhD student) Q&A afterwards. asked for further workshops and resources for the local gym " |
Year(s) Of Engagement Activity | 2019 |
Description | Genetics Matters - 3/6 scientists to participate in an activity to celebrate Rare Diseases Day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Aim was to highlight the importance of scientists, doctors, patient organisations and the public coming together to generate the critical mass and instigate change in rare disease research and in life of the patients and communities.; there were about 10 tables with scientists presenting their research, and also some charities. There was a rotating system and a new group came to our table every 15 minutes. This enabled to have a personal conversation with them about science, but also to ask them about their lives to live with a rare disease. |
Year(s) Of Engagement Activity | 2020 |
Description | Group Consultation National Spread |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | National publicity associated with RCGP meeting 5/10/18: Front page news: The Sun, Daily Telegraph, Daily Mail, BBC national news BBC1, Radio 4, online |
Year(s) Of Engagement Activity | 2018 |
Description | Hosting 6th form students lab visits |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | To discuss and demonstrate biomedical research, Lots of questions regarding research, how one does it, and its role in science teaching and in society at large. Students enthused to apply to undergraduate university courses |
Year(s) Of Engagement Activity | 2019 |
Description | Hurst - Why research is trying to MUSCLE IN on ageing |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Video production on YouTube. To increase knowledge and awareness of research into musculoskeletal ageing. |
Year(s) Of Engagement Activity | 2022 |
URL | https://t.co/fi65X2mtkv |
Description | International Paget's Disease Awereness Day |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | pariticipation through RLBUHT website and social media |
Year(s) Of Engagement Activity | 2019 |
Description | Intro to foot function and ageing for fashion students |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Liverpool university, fashion students |
Year(s) Of Engagement Activity | 2019 |
Description | Lab visits for 6th form students |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Lots of questions regarding research, how one does it, and its role in science teaching and in society at large Students enthused to apply to undergraduate university courses |
Year(s) Of Engagement Activity | 2019 |
Description | Launch of https://jointcalc.shef.ac.uk/ website - patient decision aid for joint replacement |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | to promote shared decision making, better informed decision making for patients |
Year(s) Of Engagement Activity | 2019 |
Description | MRC Festival of Medical Research workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | To share information, to stimulate thinking, and to improve understanding. Considerable Q&A regarding musculoskeletal diseases and how to maintain musculoskeletal health. Have been contacted by participants who wish to vist the lab and hear more. Have subsequently hosted a patient in the lab. |
Year(s) Of Engagement Activity | 2019 |
Description | MRC Festival of Science engagement event, Newcastle |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | 100 people attended and many asked questions on the role of nutrition, especially vitamin D in bone health |
Year(s) Of Engagement Activity | 2018 |
Description | Metabolic health, rather than weight status, contributes to endothelial dysfunction: a comparison of weight/metabolic health related phenotypes |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Metabolic health, rather than weight status, contributes to endothelial dysfunction: a comparison of weight/metabolic health related phenotypes |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.easd.org/virtualmeeting/home.html#!resources/metabolic-health-rather-than-obesity-status... |
Description | Monthly Group Consultations |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Share evidence underpinning best practice & latest research developments, 13-23 patients per clinic (1000 per year) Better understanding of core management strategy and latest evidence, translating into better care and empowerment High remission rates and evidence of enhanced self- care |
Year(s) Of Engagement Activity | 2018,2019 |
Description | Musculoskeletal biology patient involvement group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | 6 people with arthritis attended PPI meetings, academics presented project ideas, project results etc and these were discussed as a group Excellent feedback from patient group and requests for more activities |
Year(s) Of Engagement Activity | 2018,2019 |
Description | Musculoskeletal biology patient involvement group Chair and Student rep |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Discussions around musculoskeletal research plans, and dissemination of research data, increased understanding of research activities in Liverpool and CIMA; 5 people living with arthritis attended PPI meetings, academics presented project ideas, project results etc and these were discussed as a group, at Feb 20 meeting the CIMA Mres students presented their projects for discussion. Excellent feedback from patient group and requests for more activities |
Year(s) Of Engagement Activity | 2020 |
Description | Musculoskeletal biology patient involvement meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Purpose of activity: Discussions around musculoskeletal research plans, and dissemination of research data, increased understanding of research activities in ILCaMS, opportunity for CIMA Mres students to present their research to patient group. Results of activity: Excellent feedback from patient group and requests for more activities. Impact: Training for CIMA MREs students, improved understanding of MSK disease by patients, recruitment of patients for involvement in peer review of study packs for clinical trial |
Year(s) Of Engagement Activity | 2021 |
Description | Musculoskeletal biology patient involvement meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Main purpose of activity: Discussions around musculoskeletal research plans, and dissemination of research data, increased understanding of research activities in Institute of Ageing and Chronic Disease. Results of the activity: 5 people living with arthritis attended PPI meetings, academics presented project ideas, project results etc and these were discussed as a group, at Feb 20 meeting the CIMA MRes students presented their projects for discussion. Impacts: Excellent feedback from patient group and requests for more activities. |
Year(s) Of Engagement Activity | 2020 |
Description | Nutrition and healthy ageing virtual coffee morning |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | Main purpose of activity: to share information. Results of the activity: Presentations from E Stevenson and T Hill followed by discussions |
Year(s) Of Engagement Activity | 2021 |
Description | Osteoporosis 2000 Support Group talk & Q&A |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Information sharing |
Year(s) Of Engagement Activity | 2020 |
Description | PPI seminar hosted Bethan Jones UWE and her patient partner, who discussed patient participation in research |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | 2 patients have expressed a desire to partner PhD students in the institute |
Year(s) Of Engagement Activity | 2019 |
Description | Pekovic-Vaughan - Assessing sarcopenia and sleep quality in heart failure |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presented a talk on sleep quality to HF patient group as part of a workshop on lifestyle interventions in HF; this led to patient interest in the research carried out, discussion on patient experiences and the impact of medication and/or condition on sleep quality; we then formulated important research questions for further research. Patients were distributed information and resources on how to improve their sleep quality, which is a significant contributor to overall health. A follow-up workshop activity is planned in 2024. |
Year(s) Of Engagement Activity | 2023 |
Description | Pekovic-Vaughan - ECM/redox signalling axis: From cancer to tissue repair and smarter regenerative therapies |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The Biochemical Society-sponsored webinar entitled ECM/Redox Signalling Axis: From Cancer to Tissue Repair and Smarter Regenerative Therapies. >100 people attended the webinar, which sparked a discussion afterwards. The webinar recording is on the The Biochemical Society You Tube channel allowing for wider audience each and further public engagement |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.youtube.com/watch?v=QB9g_Ke531Q |
Description | Pekovic-Vaughan - Inside the Body Tardis |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Meet the Scientist event at the World Museum, Liverpool, to stimulate thinking and share information. Engaged lots of kids, parents and grandparents, measured their grip strength and heart rate in the morning and afternoon, which sparked their interest in body clocks. Invited to repeat the activity at the Museum in 2023. Also, this activity was carried out at a smaller scale in a local school as a follow-up. |
Year(s) Of Engagement Activity | 2022 |
Description | Pekovic-Vaughan - Inside the Body Tardis |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Meet the Scientist event at the World Museum, Liverpool. Engaged lots of kids, parents and grandparents, measured their grip strength and heart rate in the morning and afternoon, which sparked their interest in body clocks. Invited to repeat the activity at the Museum in 2024. Also, this activity was carried out at a smaller scale in a local school as a follow-up. |
Year(s) Of Engagement Activity | 2023 |
Description | Pekovic-Vaughan - Mechanisms and interventions in ageing |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Led one of the four round table discussions as part of the BBSCR-funded ECM Age network group to stimulate thinking and improve understanding. Led a round table discussion on the mechanisms and interventions in ageing, which stimulated participants to share their insights and experiences and inform further research. This activity will be repeated in 2023. It led to some joint pump-priming research applications with feedback from public |
Year(s) Of Engagement Activity | 2022 |
Description | Pekovic-Vaughan - Utilising chronobiology in assessing sleep quality in heart failure |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | A talk as part of a funded workshop to share information and inform decision making. Presented a talk on sleep quality to HF patient group as part of a workshop on lifestyle interventions in HF; this led to patient interest in the research carried out, discussion on patient experiences and the impact of medication and/or condition on sleep quality; we then formulated important research questions for further research. Patients were distributed information and resources on how to improve their sleep quality, which is a significant contributor to overall health. A follow-up workshop activity is planned later this year. |
Year(s) Of Engagement Activity | 2022 |
Description | Presentation on nutrition and bone health |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Main purpose of activity: Share information. Results of activity: 40 patients attended via Zoom,there was about 30 mins of questions from the audience. Impact: Feedback appeared to be very positive at the session especially during the discussion part of the talk. |
Year(s) Of Engagement Activity | 2021 |
Description | Public engagement at stand at Windsor Horse Show |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | 250 attened the stand and engeged on our equine foot balance activity engage with public interested in equine lameness and foot balance |
Year(s) Of Engagement Activity | 2019 |
Description | Public engagement stand at Liverpool Horse Show |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | 500 people attende the stand over 3 days which had a number of undergard vet students presenting vet related issues including musculoskeletal engage with potential vet students, made conatct with an undergrad who is now my Masters student, invited to give a talk at Chester University on my work |
Year(s) Of Engagement Activity | 2018 |
Description | Rice - CRISPR Cas9 Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | 50 informed lay participants attended an online lecture about the mechanism of action of CRISPR Cas9 and the ethics of genome editing technology. Gave a 40-min talk followed by a 20-min discussion. Would have been held in person if not for pandemic |
Year(s) Of Engagement Activity | 2022 |
Description | Schini - patient teaching |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation to inform patients about osteoarthritis with an opportunity to ask questions |
Year(s) Of Engagement Activity | 2022 |
Description | Senescent cells drive ageing: Kill your foes to live long |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Main purpose of activity: to stimulate thinking and improve understanding. Results of activity: 50 lay persons paid for and attended information talk and participated in a live discussion afterwards. |
Year(s) Of Engagement Activity | 2021 |
Description | Session on lessons for healthy ageing from ageing research |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Panel was Tom Kirkwood, Joao Passos, John Mathers and Malcolom Jackson |
Year(s) Of Engagement Activity | 2019 |
Description | Sky TV news item on UKSA award |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Interview with research team members and filming of laboratory activies |
Year(s) Of Engagement Activity | 2018 |
Description | Staunton - Ridgeway school careers talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Discussing career options at Ridgeway career talk |
Year(s) Of Engagement Activity | 2023 |
Description | T von Zglinicki, S Miwa - Using senolytics to cure deleterious late treatment effects. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation of research project to the Brain Tumour Charity patient involvement group. Intense discussion was stimulated. |
Year(s) Of Engagement Activity | 2023 |
Description | Talk on surgical aspects of Paget's disease |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | to share information, promoted discussion amongst participants. lecture posted on Paget's association website |
Year(s) Of Engagement Activity | 2019 |
Description | Virtual Group Consultations Webinars: Continuity of Care During Covid |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Share experience of virtual group consultations; Sharing of best practice & supporting clinical teams to deliver virtual group consultations. Each team agreeing to nominate 1-2 patient leads will feed into a creation of a global patient panel |
Year(s) Of Engagement Activity | 2020,2021 |
Description | What is Paget's Disease of Bone? |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Main purpose of the activity: To improve understanding of Paget's Disease of Bone and the treatment available Results of the activity: Improved understanding and raised awareness, which sparked participation in the Q & A session Impact: Perceived increased number of patients being referred to our Liverpool Centre of Excellence for treatment and participation in clinical studies. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=o57SbtzcgUI |
Description | What really moves you? Public lectures on the wonders of your musculoskeletal system - public talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Oral presentation to approx 60-70 general public attendees ranging in age from primary school to retired adults, followed by questions and answers |
Year(s) Of Engagement Activity | 2016 |
Description | Whysall - patient advocacy event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | discussion on diagnostic odyssey and supports for rare disorders |
Year(s) Of Engagement Activity | 2022 |
Description | Wilkinson - Design and development of a patient-focused leaflet outlining the biology behind OA and RA |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Leaflet development, presentation to and interaction with patient groups (Liverpool MSKPIP). To improve patient understanding about the biology behind musculoskeletal disease. Very positive feedback. Improved understandinf of OA as a disease. Led to successful funding of (by CIMA and faculty) of a similar leaflet to address RA. |
Year(s) Of Engagement Activity | 2021,2022,2023 |
Description | Wilkinson - Guardian Health Supplement and healthawareness.co.uk |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Description of my research in broader article about arthritis written by Versus Arthritis. |
Year(s) Of Engagement Activity | 2023 |
Description | Wilkinson - Versus Arthritis Election Manifesto segment 2024 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Provided a quote about the state of MSK funding in the UK, and the need for more govenerment funded MSK research in line with the UK ambitions as a leader in life sciences. |
Year(s) Of Engagement Activity | 2024 |
Description | Wilkinson - Versus Arthritis Winter Appeal |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | I met with a freelance writer to discuss arthritis, my research and Versus Arthritis. She drafted an appeal letter based on our discussion which I amended and commented on. I met with a photographer who took professional photographs in the lab. The letter was sent out in autumn 2023. The theme of the appeal was osteoarthritis as more than just 'wear and tear', something I (and others at UoL) have worked to improve public/patient knowledge about in our previous public engagement activities. Over £80k was raised for the charity following this campaign. |
Year(s) Of Engagement Activity | 2024 |
Description | World Arthritis Day Blog |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | TBC |
Year(s) Of Engagement Activity | 2018 |
Description | Wright - Ainsdale GP patient group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation to GP patient group - Ainsdale Medical Centre GP and Patient Participation Group "Research into the causes of, and treatments for, arthritis" Impact - new members of MKS PPI group, invitation to participate in public engagement event for world arthritis day |
Year(s) Of Engagement Activity | 2022 |
Description | Wright - Ainsdale Health Fair |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Public engagement to increase awareness of research into musculoskeletal ageing. Excellent feedback from general public and from the organiser (Mr Ken Lowe) who is a member of the PPI group detailed above. Impact - Training for PhD students and PDRAs in public engagement, increased awareness of opportunities to participate in research as a patient partner |
Year(s) Of Engagement Activity | 2022 |
Description | Wright - Ainsdale Health Fair 2023 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Ainsdale health fare runs annually to provide flu vaccinations and advice to older populations around Ainsdale, Liverpool. Dr Helen Wright ran a stall at the event, providing information about musculoskeletal health and disease. Excellent feedback from general public and from the organiser (Mr Ken Lowe) who is a member of the University of Liverpool PPI group . |
Year(s) Of Engagement Activity | 2023 |
Description | Wright - Guest lecture at the University of the 3rd Age, Bury |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Guest lecture at the University of the 3rd Age, Bury. |
Year(s) Of Engagement Activity | 2024 |
Description | Wright - Musculoskeletal biology patient involvement group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Discussions around musculoskeletal research plans, and dissemination of research data, increased understanding of research activities in ILCaMS, opportunity for CIMA MRes students to present their research to patient group. Excellent feedback from patient group and requests for more activities. Impacts - Training for CIMA MRes students, improved understanding of MSK disease by patients, recruitment of patients for involvement in peer review of study packs for clinical trial |
Year(s) Of Engagement Activity | 2022,2023 |
Description | Young, Pirog - Genetics Matter |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | 120 members of public, series of short talks followed by round table discussions and presentations, some interactive. |
Year(s) Of Engagement Activity | 2023 |
Description | Young, Pirog - Smart advances in Ageing research |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | A series of short talks were given on the theme "Smart advances in ageing research" followed by a round table discussion and presentations. |
Year(s) Of Engagement Activity | 2023 |