A protein-transcriptome atlas of haematopoiesis across the human life span
Lead Research Organisation:
University of Cambridge
Department Name: Haematology
Abstract
The cell represents a fundamental unit of biology, as all of our organs are composed of cells, where cells with different specialized functions combine to provide overall functionality. Specialization of cells is perhaps best understood in the blood system, where red blood cells for example are dedicated to carrying oxygen round the body, while a myriad of specialized immune cells help to fight infections. A better understanding of the molecular features that characterize individual cells is not only essential for us to gain a better understanding of how the human body functions normally, but also to be able to design better drugs that can reverse the abnormal behaviour of cells, which causes many diseases including blood cancers and immune disorders.
Recent technological innovations have made it possible to map very comprehensively the activity of all genes within single cells, at a scale of thousands of cells at the same time. We propose to utilize one of the latest protocols in this field to map both messenger RNA as well as protein levels, and thus obtain especially detailed insights into the molecular make up of over 550,000 individual blood and immune cells across the human lifespan. Through integration with the wider Human Cell Atlas Initiative, our datasets will deliver an important reference, that will serve as a platform for future studies aiming to reveal the molecular alterations that cause the misbehaviour of blood cells in a broad range of disorders including blood cancers and immune diseases.
Recent technological innovations have made it possible to map very comprehensively the activity of all genes within single cells, at a scale of thousands of cells at the same time. We propose to utilize one of the latest protocols in this field to map both messenger RNA as well as protein levels, and thus obtain especially detailed insights into the molecular make up of over 550,000 individual blood and immune cells across the human lifespan. Through integration with the wider Human Cell Atlas Initiative, our datasets will deliver an important reference, that will serve as a platform for future studies aiming to reveal the molecular alterations that cause the misbehaviour of blood cells in a broad range of disorders including blood cancers and immune diseases.
Technical Summary
The recent development of Cite-Seq technology coupled with the commercialization of dedicated antibody and droplet-based sequencing reagents represent a golden opportunity to generate a comprehensive Cite-Seq dataset to complement ongoing projects across the Human Cell Atlas Initiative. We have assembled a team of PIs with expert knowledge of human fetal and adult haematopoiesis as well as single cell molecular profiling techniques, complemented with expert collaborators with specialist knowledge of experimental and computational aspects of Cite-Seq technology.
Cite-Seq technology enables the joint profiling of mRNA and protein from the same single cells using high-throughput next generation sequencing technology. The specific aims of our proposal are to (i) use Cite-Seq to generate combined protein and transcriptome profiles for over 550,000 haematopoietic progenitor and mature cells across the human lifespan, and (ii) to integrate the resulting datasets into the Human Cell Atlas data platform and establish pipelines for single cell multi-omics analysis. Subfractionation based on CD34+ and CD34- cell subsets will provide the progenitor and mature populations respectively. Samples will be obtained from fetal liver, yolk sac, and bone marrow, newborn cord blood, adult bone marrow and spleen and aged adult bone marrow. Sample acquisition will occur under already existing ethics permissions, thus ensuring that the project can start without any delay.
The proposed Cite-Seq datasets for haematopoietic progenitor and mature cells across the human lifespan will provide a multiomic resource highly complementary to currently ongoing HCA projects. Development of data analysis and data integration pipelines will furthermore provide important guidance for future adaptation of the Cite-Seq method not just to projects mapping other tissues, but also to investigators studying blood and/or immune cell disorders.
Cite-Seq technology enables the joint profiling of mRNA and protein from the same single cells using high-throughput next generation sequencing technology. The specific aims of our proposal are to (i) use Cite-Seq to generate combined protein and transcriptome profiles for over 550,000 haematopoietic progenitor and mature cells across the human lifespan, and (ii) to integrate the resulting datasets into the Human Cell Atlas data platform and establish pipelines for single cell multi-omics analysis. Subfractionation based on CD34+ and CD34- cell subsets will provide the progenitor and mature populations respectively. Samples will be obtained from fetal liver, yolk sac, and bone marrow, newborn cord blood, adult bone marrow and spleen and aged adult bone marrow. Sample acquisition will occur under already existing ethics permissions, thus ensuring that the project can start without any delay.
The proposed Cite-Seq datasets for haematopoietic progenitor and mature cells across the human lifespan will provide a multiomic resource highly complementary to currently ongoing HCA projects. Development of data analysis and data integration pipelines will furthermore provide important guidance for future adaptation of the Cite-Seq method not just to projects mapping other tissues, but also to investigators studying blood and/or immune cell disorders.
Planned Impact
Generation of a comprehensive protein-transcriptome atlas of haematopoiesis across the human lifespan is likely to have substantial impact across a range of stakeholders of MRC-funded research, as outlined below:
Human Cell Atlas Initiative: The work proposed here represents the first concerted effort to employ Cite-Seq technology in a systematic fashion to map single cell states for a major human organ across the lifespan. The resulting dataset therefore has potential to constitute a significant component of the HCA in itself. Moreover, lessons learned from computational analysis and data integration are likely to be broadly useful for future HCA-directed analysis of other organ systems, including tools that can map between spatial data (Hyperion CyTOF) and suspension cell single cell profiling by Cite-Seq, where measurement of the same proteins with both assays serves as a common denominator to facilitate data integration.
Broader biomedical research community: The open access philosophy of the HCA means that our datasets will be freely available to the broader community at the earliest opportunity. Likely applications will include the use of our dataset as a reference to assess perturbations, either experimentally induced or when studying patient samples. The computational analysis pipelines will also represent a platform for the bioinformatics community to develop tools for the analysis of single cell multiomic datasets.
Industry: The pharmaceutical and biotech industry critically depends on high-level characterisation of preclinical model systems, to enable the creation of better disease models and thus reduce the exorbitant costs associated with late stage failure in drug development programmes. Single cell molecular profiling is rapidly recognised as a potentially very powerful analytical technique for the characterisation of all biological systems, including disease and preclinical models. A particularly attractive feature of Cite-Seq in this context is the multidimensional nature of the data, including comprehensive information on protein expression.
Training: Although the experimental staff requested for this project is small, and taking advantage of existing expertise across the PIs' laboratories, there is a substantial need for training more young scientists in computational analytical techniques. In this context, the computational post offers exciting opportunities. The lead PI has a strong track record in training young bioinformaticians, evidenced for example by the fact that his former postdoc David Ruau currently fulfils the very senior role of Head of Data Science at Bayer, and his former postdoc Anagha Joshi is a full professor at the University of Bergen. Moreover, the named collaborators John Marioni and Rahul Satija are both internationally leading in the field of computational single cell biology.
General Public: Although relatively small on its own, the work proposed here will form a component of the wider HCA Initiative, which regularly receives news coverage in both the international and national press. We will work with our press and outreach teams in Cambridge and Newcastle, to reach out to the public locally and across the UK, with the overall goal of increasing the public understanding of science and the importance of public buy-in for large initiatives such as the HCA. To this end, we also aim to take advantage of occasions where the broader HCA project is in the news, so that we can highlight contributions made through MRC funding.
Human Cell Atlas Initiative: The work proposed here represents the first concerted effort to employ Cite-Seq technology in a systematic fashion to map single cell states for a major human organ across the lifespan. The resulting dataset therefore has potential to constitute a significant component of the HCA in itself. Moreover, lessons learned from computational analysis and data integration are likely to be broadly useful for future HCA-directed analysis of other organ systems, including tools that can map between spatial data (Hyperion CyTOF) and suspension cell single cell profiling by Cite-Seq, where measurement of the same proteins with both assays serves as a common denominator to facilitate data integration.
Broader biomedical research community: The open access philosophy of the HCA means that our datasets will be freely available to the broader community at the earliest opportunity. Likely applications will include the use of our dataset as a reference to assess perturbations, either experimentally induced or when studying patient samples. The computational analysis pipelines will also represent a platform for the bioinformatics community to develop tools for the analysis of single cell multiomic datasets.
Industry: The pharmaceutical and biotech industry critically depends on high-level characterisation of preclinical model systems, to enable the creation of better disease models and thus reduce the exorbitant costs associated with late stage failure in drug development programmes. Single cell molecular profiling is rapidly recognised as a potentially very powerful analytical technique for the characterisation of all biological systems, including disease and preclinical models. A particularly attractive feature of Cite-Seq in this context is the multidimensional nature of the data, including comprehensive information on protein expression.
Training: Although the experimental staff requested for this project is small, and taking advantage of existing expertise across the PIs' laboratories, there is a substantial need for training more young scientists in computational analytical techniques. In this context, the computational post offers exciting opportunities. The lead PI has a strong track record in training young bioinformaticians, evidenced for example by the fact that his former postdoc David Ruau currently fulfils the very senior role of Head of Data Science at Bayer, and his former postdoc Anagha Joshi is a full professor at the University of Bergen. Moreover, the named collaborators John Marioni and Rahul Satija are both internationally leading in the field of computational single cell biology.
General Public: Although relatively small on its own, the work proposed here will form a component of the wider HCA Initiative, which regularly receives news coverage in both the international and national press. We will work with our press and outreach teams in Cambridge and Newcastle, to reach out to the public locally and across the UK, with the overall goal of increasing the public understanding of science and the importance of public buy-in for large initiatives such as the HCA. To this end, we also aim to take advantage of occasions where the broader HCA project is in the news, so that we can highlight contributions made through MRC funding.
Title | Art Project with Blood Cancer UK and Kettle's Yard |
Description | A Pattern for Progress, was initiated as a part of the artwork commission for the Jeffrey Cheah Biomedical Centre to bring new audiences on campus into contact with our research. The public engagement team facilitated the partnership between artist Harold Offeh, the local MS Society and stem cell researchers to explore their common interests and the ensure that patient perspectives were a visible and valued part of the fabric of our new building. |
Type Of Art | Artwork |
Year Produced | 2020 |
Impact | The success of A Pattern For Progress has initiated a new wave of art collaborations with the MS Society across Cambridgeshire and East Anglia including a graffiti wall project in Peterborough, Huntington an Ely. Bob Bragger from the MS Society has become an integral part of the Institute's engagement network, speaking to researchers, funders and public engagement practitioners to share the learnings from the project. Bob has also joined our Institute Public Engagement Steering Committee to feed into future patient-led engagement approaches, and continues to connect us to other patient charities including local branches of Parkinson's UK and NHS Trusts. |
URL | https://www.stemcells.cam.ac.uk/about-us/jcbc/art/commissions/harold-offeh |
Description | Dr Nicola Wilson from the Gottgens Lab was Panel member of Wellcome Townhall meeting - London - virtual 2020 |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Membership of a guideline committee |
Description | Dr Nicola Wilson influence on local University panels |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Membership of a guideline committee |
Description | Circadian rhythms and micro-environmental signals control LT-HSC differentiation and self-renewal: the roles of TNF and melatonin |
Amount | £74,546 (GBP) |
Funding ID | 129450 |
Organisation | Weizmann UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2021 |
End | 01/2023 |
Description | Collaborative Research Grant |
Amount | £26,000 (GBP) |
Organisation | Wiener-Anspach Foundation |
Sector | Charity/Non Profit |
Country | Belgium |
Start | 09/2018 |
End | 12/2020 |
Description | Covid-related extension |
Amount | £42,071 (GBP) |
Organisation | United Kingdom Research and Innovation |
Sector | Public |
Country | United Kingdom |
Start | 04/2021 |
End | 08/2021 |
Description | Generating a global view of cell lineage trees during early mouse embryo development |
Amount | £300,000 (GBP) |
Funding ID | 215920/Z/19/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2023 |
Description | Human Cell Atlas - Development Atlas Extension |
Amount | £3,444,569 (GBP) |
Funding ID | 221052/Z/20/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Human Developmental Biology Initiative |
Amount | £10,000,000 (GBP) |
Funding ID | 215116/Z/18/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2024 |
Description | Human blood stem cell expansion: Empowering new technology for stem cell medicine |
Amount | £634,915 (GBP) |
Funding ID | MR/V005502/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2023 |
Description | Molecular mechanisms of cell fate decisions in gastrulation and early organogenesis |
Amount | £3,984,304 (GBP) |
Funding ID | 220379/B/20/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Single cell profiling of open chromatin status in human bone marrow mononuclear cells from young and old donors |
Amount | £52,779 (GBP) |
Organisation | Aging Biology Foundation Europe |
Sector | Private |
Country | Czech Republic |
Start | 03/2020 |
End | 03/2022 |
Description | A protein-transcriptome atlas of haematopoiesis across the human life span |
Organisation | Newcastle University |
Department | Institute of Cellular Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Using Cite-Seq technology to generate combined protein and transcriptome profiles for haematopoietic progenitor and mature cells across the human lifespan |
Collaborator Contribution | Providing human samples and performing Cite-Seq analysis |
Impact | The collaboration began in December 2018 and will run to April 2021. Our primary output, combined protein and transcriptome profiles for haematopoietic progenitor and mature cells across the human lifespan which will feed into the Human Cell Atlas, will be produced incrementally through the duration of the collaboration. Data will be made freely available through the Human Cell Atlas portal and the DNA sequencing databases maintained by EBI and NCBI. We also aim to publish report of our research which will demonstrate the application of Cite-Seq technology. |
Start Year | 2018 |
Description | A protein-transcriptome atlas of haematopoiesis across the human life span |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Using Cite-Seq technology to generate combined protein and transcriptome profiles for haematopoietic progenitor and mature cells across the human lifespan |
Collaborator Contribution | Providing human samples and performing Cite-Seq analysis |
Impact | The collaboration began in December 2018 and will run to April 2021. Our primary output, combined protein and transcriptome profiles for haematopoietic progenitor and mature cells across the human lifespan which will feed into the Human Cell Atlas, will be produced incrementally through the duration of the collaboration. Data will be made freely available through the Human Cell Atlas portal and the DNA sequencing databases maintained by EBI and NCBI. We also aim to publish report of our research which will demonstrate the application of Cite-Seq technology. |
Start Year | 2018 |
Description | Capturing the Early Stages of Acute Myeloid Leukaemia to Evaluate New Therapeutics |
Organisation | AstraZeneca |
Country | United Kingdom |
Sector | Private |
PI Contribution | scRNA-Seq analysis of drug treatment on mixed lineage leukaemia |
Collaborator Contribution | In vivo validation |
Impact | The collaboration began in January 2019 and will run until July 2020. Full output will not be available until late in the collaboration when we should be able to identify molecules (or combinations of molecules) that are specifically effective against leukaemic and/or pre-leukaemic cells. |
Start Year | 2019 |
Description | Human Developmental Biology Initiative |
Organisation | Babraham Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are leading the studies focusing on blood cell development during gastrulation. |
Collaborator Contribution | Our partners are leading studies focusing on the development other other cell types during gastrulation. |
Impact | Thirteen laboratories around the UK are working together to study human embryo development. The project has only just begun, but it aims to provide freely available data and produce a family tree of the cell divisions that occur during embryo development. |
Start Year | 2019 |
Description | Human Developmental Biology Initiative |
Organisation | Francis Crick Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are leading the studies focusing on blood cell development during gastrulation. |
Collaborator Contribution | Our partners are leading studies focusing on the development other other cell types during gastrulation. |
Impact | Thirteen laboratories around the UK are working together to study human embryo development. The project has only just begun, but it aims to provide freely available data and produce a family tree of the cell divisions that occur during embryo development. |
Start Year | 2019 |
Description | Human Developmental Biology Initiative |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are leading the studies focusing on blood cell development during gastrulation. |
Collaborator Contribution | Our partners are leading studies focusing on the development other other cell types during gastrulation. |
Impact | Thirteen laboratories around the UK are working together to study human embryo development. The project has only just begun, but it aims to provide freely available data and produce a family tree of the cell divisions that occur during embryo development. |
Start Year | 2019 |
Description | Human Developmental Biology Initiative |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are leading the studies focusing on blood cell development during gastrulation. |
Collaborator Contribution | Our partners are leading studies focusing on the development other other cell types during gastrulation. |
Impact | Thirteen laboratories around the UK are working together to study human embryo development. The project has only just begun, but it aims to provide freely available data and produce a family tree of the cell divisions that occur during embryo development. |
Start Year | 2019 |
Description | Human Developmental Biology Initiative |
Organisation | University of Oxford |
Department | Oxford Hub |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are leading the studies focusing on blood cell development during gastrulation. |
Collaborator Contribution | Our partners are leading studies focusing on the development other other cell types during gastrulation. |
Impact | Thirteen laboratories around the UK are working together to study human embryo development. The project has only just begun, but it aims to provide freely available data and produce a family tree of the cell divisions that occur during embryo development. |
Start Year | 2019 |
Description | Black scientists panel event - Nicola Wilson was an organiser |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Nicola Wilson organised a workshop/panel to discuss and promote black scientists in research. |
Year(s) Of Engagement Activity | 2022 |
Description | Blood Cancer Awareness Month. The Gottgens Lab were involved in advising a piece of artwork on public display in the Jeffrey Cheah Biomedical Centre |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Anna Brownsted's The Night the Mountains Moved, responds to a project bringing together patient ambassadors for Blood Cancer UK and stem cell researchers working at the Jeffrey Cheah Biomedical Centre. The artwork, an installation of prints collaged directly to the wall, is inspired by the workshop participants' animated sequences which were made with photographs from issues of National Geographic published in 1960 (the year Blood Cancer UK officially became a charity). These photographs, magnified in The Night the Mountains Moved to an extreme scale that emphasises the grain and dots of the original printing techniques, depict momentous events from that year - including the record-setting high-altitude leap into space by Joseph Kittinger. Placed alongside these are more ordinary images, lifted from the magazines' advertisements, which have been digitally manipulated into vibrant, repetitive patterns. The artwork was commissioned by the Wellcome - MRC Cambridge Stem Cell Institute as part of its Public Engagement programme, working together with Blood Cancer UK and Kettle's Yard. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.kettlesyard.co.uk/about/news/reflections-from-home-no-10-anna-brownsted-cambridge-englan... |
Description | Cambourne Crescent group visit to Cambridge Stem Cell Institute |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Nicola Wilson, Mariana Quiroga-Londono and Myriam Haltalli were involved in a visit by the Cambourne Crescent group to the Cambridge Stem Cell Institute to view and talk about our ongoing science. |
Year(s) Of Engagement Activity | 2022 |
Description | Cambourne school STEM week - Nicola Wilson was a participant |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Nicola Wilson participated at Cambourne school with the 2022 STEM week. |
Year(s) Of Engagement Activity | 2022 |
Description | Dr Nicola Wilson and Dr Fernando Calero participated in a Covid project and were interviewed on a UK and Spanish media platform |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | The largest study of its type in the UK has identified differences in the immune response to COVID-19 between asymptomatic people and those suffering more severely with the virus. Researchers at the Cambridge Stem Cell Institute are part of a team working across the University of Cambridge, Wellcome Sanger Institute, Newcastle University, University College London and EMBL's European Bioinformatics Institute (EMBL-EBI), who have found raised levels of specific immune cells in asymptomatic people with COVID-19. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood clotting symptoms, and could be used to identify potential targets for developing therapies. The research, in Nature Medicine, is one of the only studies to include people who were asymptomatic. Additional URL: https://www.newtral.es/coronavirus-asintomatico-nariz-anticuerpos/20210430/ |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.stemcells.cam.ac.uk/news/covid-19-variation-immune-response |
Description | Dr Nicola Wilson from the Gottgen Lab participated in Primary School Science Week involving 60 Year 6 children. The project was 'Make your own cell'. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Dr Wilson participated and ran a school project at a local Cambridge school in 2021. The project was entitled 'Make your own cell' |
Year(s) Of Engagement Activity | 2021 |
Description | Interview with Nature Methods |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Interview with Bertie Gottgens explaining our research to a wider audience |
Year(s) Of Engagement Activity | 2019 |
URL | https://protocolsmethods.springernature.com/users/203750-nicole-rusk/posts/43425-a-chat-with-bertie-... |
Description | Mariana Quiroga-Londono developed "Code for change", an interactive platform teaching Python through bioinformatics challenges. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Code for a Change is an online interactive platform created during COVID-19 outbreak that aims to encourage people to develop programming skills. This community offers free coding lessons in the programming language Python, a coding challenge for beginners, and the opportunity to contribute to a charitable cause. |
Year(s) Of Engagement Activity | 2021,2022 |
URL | https://www.codeforachange.com |
Description | Nature Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Description of research project |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.nature.com/articles/d41586-019-00644-6 |
Description | Newmarket Community Concert |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Sarah Kinston and Rebecca Hannah participated in a music concert in Newmarket to raise money for charity. The audience were able to talk to our representatves regarding the work at the Cambridge Stem Cell Institute after the concert. |
Year(s) Of Engagement Activity | 2022 |
Description | Responsive Research film on Prof Bertie Gottgens research |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Bertie Gottgens was involved in a short film regarding his current research. |
Year(s) Of Engagement Activity | 2022 |
Description | Single cell multiomics approaches organised by Wiley and 10x genomics |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Single cell multiomics approaches organised by Wiley and 10x genomics Presentation by Nicola Wilson: "A protein-transcriptome atlas of haematopoiesis across the human" |
Year(s) Of Engagement Activity | 2022 |
Description | Stem Cell Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Interview with Bertie Gottgens for a podcast in which we explained our research to a wider audience |
Year(s) Of Engagement Activity | 2019 |
URL | https://stemcellpodcast.com/ep-143-cell-fate-decisions-at-single-cell-resolution-featuring-dr-bertie... |
Description | Unknown Unknowns in conversation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Mariana Quiroga-Londono was a speaker at an event entitled: 'Unknown Unknowns in Conversation'. |
Year(s) Of Engagement Activity | 2022 |
Description | You Tube videos as part of the 2022 Cambridge Science Festival |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Short online interviews with Cambridge Stem Cell Institute researchers as part of the Cambridge Festival 2022. Bertie discusses his research on Covid-19 and how life as a stem cell scientist has changed during the pandemic |
Year(s) Of Engagement Activity | 2022 |