A Preservation and Packaging Platform for Cell and Tissue Based Therapies
Lead Research Organisation:
Loughborough University
Department Name: Sch of Mechanical and Manufacturing Eng
Abstract
This project aims to create a preservation and packaging platform for cell and tissue based therapies, allowing UK companies to reach the European, North American and other global markets. Traditionally, preservation, storage and transportation solutions for biological entities, mostly protein-based, have involved lyophilisation (freeze drying) and/or cryopreservation. However, living cells constitute an essential part of cell therapy applications and there is a real and urgent need for packaging solutions that preserve cell viability and function post transport, and provide ease-of-use to the end-user in clinic. Validatable packaging platforms that allow improved preservation and shelf life of living products will give UK businesses the capability to reach world markets from UK sites and maximise their share of the global value chain. This project will demonstrate key components of a packaging and shipping platform for human cell and tissue based therapies.
Publications
David John Williams (Author)
(2011)
Effects of Dynamical Mechanical Forces on Human Mesenchymal Stem Cell Therapy Products
David John Williams (Author)
(2012)
Scale up and Manufacturing of Cell-Based Therapies
Nikolay Nikolaev (Author)
(2012)
Effect of Cold Storage and Mechnical Vibration on Human Mesenchymal Stem Cell Therapeutic Products Transported in Suspension
Description | This project aimed to create a preservation and packaging platform for cell and tissue based therapies, allowing UK companies to reach the European, North American and other global markets. Traditionally, preservation, storage and transportation solutions for biological entities, mostly protein-based, have involved freezing or freeze drying. However, living cells constitute an essential part of cell therapy applications and there is a real and urgent need for packaging solutions that preserve cell viability and function post transport, and provide ease-of-use to the end-user in clinic. Validatable packaging platforms that allow improved preservation and shelf life of living products will give UK businesses the capability to reach world markets from UK sites and maximise their share of the global value chain. This project has demonstrated key components of a packaging and shipping platform for human cell and tissue based therapies in particular the use of mathematical modelling for package design and the effects of temperature and vibration during cold chain shipping of therapeutic cell types. |
Exploitation Route | Mathematical models for the design of packaging have been implemented by an industrial partner. Measurement of the effects of vibration experienced by cells in transportation has identified the requirement to better understand the underlying phenomena in order to improve the design of transport systems. |
Sectors | Healthcare Pharmaceuticals and Medical Biotechnology Transport |
URL | http://www.lboro.ac.uk/research/lcbe/research/current-projects/preservation-packaging.html |
Description | Mathematical models for the design of packaging have been implemented by an industrial partner. |
First Year Of Impact | 2010 |
Sector | Healthcare,Pharmaceuticals and Medical Biotechnology,Transport |
Impact Types | Economic |
Description | CDT Capital - Atomic Force Microscope |
Amount | £120,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2015 |
End | 03/2015 |
Description | AFM characterisation of cell mechanics |
Organisation | JPK Instruments |
Country | Germany |
Sector | Private |
PI Contribution | JPK have given in-kind support of access to NanoWizard 3 BioScience AFM facilities and staff time working on characterisation of cell mechanical properties |
Start Year | 2011 |