Studies of nutrient uptake in Mycobacterium bovis - the causative agent of bovine tuberculosis

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

Bovine tuberculosis is a disease of global importance. It is estimated that the worldwide losses to agriculture from this disease amount to $3 billion per annum. The major causative agent of bovine tuberculosis (TB) is Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex. Bovine TB is a disease of high economic relevance within livestock farming since it directly affects animal productivity and influences the export of meat and dairy products.
In this project we want to determine how M. bovis obtains and exploits essential nutrients - with the aim of determining the essentiality of these uptake systems and determining the structure, function and mechanisms of these transport systems. We will undertake a cutting-edge multidisciplinary approach to understand the key nutrient transport processes of this pathogen. This research has clear potential to impact on the agricultural industry with biotechnological applications.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
1642867 Studentship BB/M01116X/1 05/10/2015 30/05/2020 Magdalena Maria Karlikowska
 
Description EMBO Travel Support Grant
Amount € 300 (EUR)
Organisation European Molecular Biology Organisation 
Sector Charity/Non Profit
Country Germany
Start 02/2020 
End 02/2020
 
Description Flexible Talent Mobility Account 2 (FTMA2)
Amount £28,014 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 10/2020
 
Description Microbiology Society Conference Grant 2018
Amount £240 (GBP)
Funding ID GA000336 
Organisation Microbiology Society 
Sector Learned Society
Country United Kingdom
Start 04/2018 
End 04/2018
 
Description Microbiology Society Conference Grant 2020 Round 1
Amount £390 (GBP)
Funding ID GA001832 
Organisation Microbiology Society 
Sector Learned Society
Country United Kingdom
Start 02/2020 
End 02/2020
 
Description AMR Outreach Event - University of Warwick 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 80 members of general public attended for a research visit to University of Warwick. I was responsible for one of the information stations, explaining how the fluorescence microscopy works, including examples from my own research. The visit sparked questions and discussion, and the feedback received from my audience reported increased understanding and interest in the studies of Mycobacterium tuberculosis.
Year(s) Of Engagement Activity 2016
 
Description APPG TB (All Party Parliamentary Group on Global Tuberculosis) World TB Day 2016 Event at the Parliament 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Met with Nick Herbert MP and other MPs to highlight the importance of Global Fund replenishment. This had a real impact as the UK pledged a fantastic £1.1 billion in support of ending the AIDS/HIV, TB, and Malaria. Through its pledge to the Global Fund, the UK will help save 100 lives every hour from these deadly diseases.
Year(s) Of Engagement Activity 2016
 
Description New Scientist Live - London Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact University of Warwick Science Department Exhibition during the New Scientist Live. The Exhibition included various games and activities for children as well as informative posters. We also gave out prices to competition winners. In particular, I spoke to general public about the tuberculosis research at University of Warwick. By explaining the global impact of tuberculosis and raising its profile, I challenged public assumptions about the infection. The event was very successful and our university has continued to participate in the following years.
Year(s) Of Engagement Activity 2017
URL https://live.newscientist.com/new-scientist-live-2017?page=6
 
Description Skills Mentor 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Provided unbiased advice, direction and discussion for University of Warwick's MSc students related to the skills they will need as MSc students: communication, poster presentations, seminar presentations, research searches, literature searches, referencing/reference manager software etc.
Year(s) Of Engagement Activity 2019,2020
 
Description University of Warwick Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact I spoke to prospective students and their parents/guardians, throughout the day, on the global impact of Mycobacterium tuberculosis, raising its profile and challenging public assumptions about the disease. I also explained the research we are conducting at Warwick to help fight TB.
Year(s) Of Engagement Activity 2017
 
Description University of Warwick Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact I spoke to prospective students and their parents/guardians, throughout the day, on the global impact of Mycobacterium tuberculosis, raising its profile and challenging public assumptions about the disease. I also explained the research we are conducting at Warwick to help fight TB.
Year(s) Of Engagement Activity 2019
 
Description World TB Day 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact An information stand in a local shopping centre in Coventry. Together with my research team, we spread awareness of tuberculosis burden globally but also locally in West Midlands. I spoke to general public about the symptoms, prevention, diagnosis and treatment of tuberculosis. I also explained the research we are conducting at University of Warwick to help fight TB. In addition, we offered games and competitions for the younger audience.

I set up a collaboration with St Peter's Centre and FWT, a centre for woman for this event. These are not for profit organisations working with the local community, including refugees, and it allowed us to have a wider reach out. We provided them with information leaflets, which were then distributed in both centres.
Year(s) Of Engagement Activity 2017
 
Description World TB Day 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We organised two events for the World TB Day 2018. We had an information stand in the Coventry library and in the Herbert Art Gallery and Museum on separate days. Together with my research team, we spread awareness of tuberculosis burden globally but also locally in West Midlands. I spoke to general public about the symptoms, prevention, diagnosis and treatment of tuberculosis. I also explained the research we are conducting at University of Warwick to help fight TB. For the younger audience, we offered games on iPads to teach them the concept of antibiotic resistance.
Year(s) Of Engagement Activity 2018