Understanding the differential and complementary roles of SGK isoforms associated with the PI 3kinase and Akt signalling

Lead Research Organisation: University of Dundee
Department Name: School of Life Sciences

Abstract

This project work builds on previous exciting collaborative research between the Alessi lab and AstraZeneca that indicated that SGK protein kinases play critical roles in driving proliferation and survival of cancer cells (Sommer EM et al., Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors, Biochem J. 2013;452:499-508 {http://www.biochemj.org/bj/452/0499/bj4520499.htm} and Bago, R et al., Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. Biochem J. 2014 463:413-27 {http://www.biochemj.org/bj/463/0413/bj4630413.htm}.

The aim of this studentship will be to undertake research in order to define how SGK isoforms are regulated and how they function. A key question will be to determine whether inhibiting SGKs could result in a novel therapeutic strategy to better treat cancer in the future.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/N504221/1 01/10/2015 30/09/2019
1644353 Studentship BB/N504221/1 07/09/2015 06/09/2019 Hannah Tovell
 
Description MRCPPU PhD Student Profile 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact MRCPPU PhD Student and PostDoc Profiles launched in 2017. Interviews with PhD students and PostDocs in the Unit, describing their research aims and experiences in academic research. Profile of my work featured as a part of this, hosted on the MRCPPU website and shared on MRCPPU Twitter and Instagram Feeds to reach a more general public audience. Aim
Year(s) Of Engagement Activity 2017
URL https://www.ppu.mrc.ac.uk/about-us/phd-and-postdoc-profiles