Manganese-Catalysed C-H Bond Activation Reactions of Pyridine and Imines

Lead Research Organisation: University of York
Department Name: Chemistry

Abstract

Elementally sustainable catalytic C-H bond activation of organic compounds, with suitable heteroaromatic, imine and imide moieties, exploiting the reactivity of Mn(I), will be examined. Acceptor molecules (alkynes, alkenes and carbonyls) will be used as coupling partners. Computation will enable reactivity patterns at Mn(I) to be discerned.

Catalytic and stoichiometric processes will be investigated, the latter to help aid delineation of any rate determining state(s). The project is geared towards generating synthetically useful methodologies, and valuable organic products, in a sustainable and cost effective way, which is critical for industry and academia. The research aligns with Catalysis (EPSRC priority area), Synthetic Organic Chemistry and the Dial-a-Molecule Grand Challenge.

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509413/1 30/09/2015 29/09/2020
1644906 Studentship EP/N509413/1 30/09/2015 29/09/2019 Lars Hammarback
 
Description Several key findings have been made during the project up to this date. However, this project is sponsored by the company Syngenta and through this funding the results are protected and unpublished results cannot be shared publicly at this point.
Key published results have included the use of time-resolved infra red spectroscopy to study individual steps within a catalytic cycle, namely the C-C bond formation in Mn(I)-catalysed C-H functionalisation reactions. The mechanism of these reactions has also been studied using more traditional methods and a substrate dependent catalyst activation pathway and several independent catalytic cycles has been observed for these reactions. Also, the role of acid additives in the reactions has been determined to depend on the resting state of the catalysis.
Exploitation Route Our published findings can be used in intelligent design of new catalysts for Mn(I)-catalysed C-H bond funcationalisation. There is also an opportunity for others to base further mechanistic studies on our work for similar systems.
Sectors Agriculture, Food and Drink,Chemicals,Education,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology