How does a plant immune receptor complex confer disease resistance?

Lead Research Organisation: University of East Anglia
Department Name: Sainsbury Laboratory

Abstract

Plant disease resistance genes enable plants to detect pathogen molecules, and then activate defence. How this works is not understood.

Arabidopsis RPS4 and RRS1 resistance proteins form a protein complex that activates defence upon detection of bacterial effector proteins AvrRps4 or PopP2. RRS1 acts as a sensor R-protein; when AvrRps4 or PopP2 interact with its WRKY domain, RPS4-dependent defence is activated. The main goal of the project is to understand the properties and intra-/inter-molecular interactions of the domains within the RPS4/RRS1 proteins, in order to better understand how AvrRps4 and PopP2 recognition converts an inactive complex to a defence-activating complex.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
1654289 Studentship BB/M011216/1 01/10/2015 30/09/2019 Hannah Brown
 
Description Norwich Research Park Undergraduate TSL summer school workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Lead a laboratory practical on skills and tools used in the field of plant pathology and applications of this research for 2nd year Undergraduate students completing their summer internships at the Institute. Practical was themed around my own research at looking at the activation mechanism of plant immune receptors
Year(s) Of Engagement Activity 2016
URL https://www.jic.ac.uk/training-careers/work-experience/17-and-over/undergraduate-summer-school/
 
Description Norwich Science Festival TSL stall 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Assisted in the running and organisation several plant pathology themed practicals targeted towards the general public as part of the Sainsbury Laboratory stall at the public engagement festival advertising the innovative science being conducted at the Research park and the current challenges facing global food security
Year(s) Of Engagement Activity 2016
URL http://norwichsciencefestival.co.uk/
 
Description Volunteer on TSL stall at Norwich Science Festival 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Assisted on my PhD institute's ( The Sainsbury Laboratory) stall at the Norwich science festival. Stall consisted of several plant pathology themed practicals targeted towards the general public advertising the innovative science being conducted at the Research Park and the current challenges facing global food security.
Year(s) Of Engagement Activity 2018
URL https://norwichsciencefestival.co.uk/
 
Description Women of the Future 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The event was attended by over 200 female years 10 students from schools across Norfolk and North Suffolk with the aim at encouraging girls to work to pursue STEMM careers and take STEMM subjects and A-Level and University. I participated in my institute's stall which ran plant pathology themed practicals and also featured posters of our bios showing our journey to becoming biology PhD students. We also answered career questions such as what subjects we had studied at university and what we were hoping to after our PhDs.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/training-careers/work-experience/women-of-the-future/
 
Description Women of the Future Conference 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The event was attended by 170 girls, largely year 10, from 17 schools across Norfolk and Suffolk. The event was hosted at the John Innes Centre and was designed to inspire the next generation of female STEMM professionals. As well as attending talks and Q&A sessions with researchers from the research park there was a session where the girls got to interact with a number of female PhD students from the research park to learn about their research and experience working in a STEMM profession. I partook in this session where I also presented a poster of my PhD research thus far.
Year(s) Of Engagement Activity 2016
URL https://www.jic.ac.uk/news-and-events/news/2016/11/-women-future-2016/