Chemical Tools to Probe the Role of Bromodomains in the Parasite Trypanosoma cruzi

Lead Research Organisation: University of Oxford
Department Name: Oxford Chemistry

Abstract

The acetylation of lysine on histones tails is a key post-translational modification (PTM), which affects gene expression in a wide range of species. Bromodomains are readers for such PTMs, and have been shown to be ligandable targets that affect human diseases including cancer, inflammation, and diabetes. The function of bromodomains in non-human organisms is poorly understood, however, given the fundamental role played by bromodomains in regulating transcription in humans, we hypothesise that bromodomain-containing proteins will play equally important roles in other organisms. The aim of the project is to design, synthesize and optimize small molecules to probe the function of bromodomain-containing proteins from the parasite Trypanosoma cruzi.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M015157/1 30/09/2015 29/09/2019
1658843 Studentship BB/M015157/1 30/09/2015 29/09/2019 Corentine Laurin
 
Description Parasite network 
Organisation Genome Research Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017
 
Description Parasite network 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017
 
Description Parasite network 
Organisation National University of Rosario
Country Argentina 
Sector Academic/University 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017
 
Description Parasite network 
Organisation University of Georgia
Country United States 
Sector Academic/University 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017
 
Description Parasite network 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017
 
Description Parasite network 
Organisation University of Oxford
Department Structural Genomics Consortium (SGC)
Country United Kingdom 
Sector Public 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017
 
Description Parasite network 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies.
Collaborator Contribution Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies.
Impact Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology.
Start Year 2017