Enzyme beads for controlled alcohol oxidations in chemical synthesis

Lead Research Organisation: University of Oxford
Department Name: Oxford Chemistry


Biocatalysis offers great advantages in selectivity for oxidation of primary alcohols. Alcohol dehydrogenase enzymes are available for many alcohol oxidation steps, but a barrier to their implementation is their dependence on the cofactor NAD+. This project provides a novel solution to this challenge by developing enzyme beads that recycle NAD+ to oxidise primary alcohol functionalities in controlled ways, while releasing H2 gas as a bonus byproduct. This exploits a strong synergy between new cofactor recycling routes under development in the Vincent group and robust, broad-specificity alcohol dehydrogenase enzymes developed by the industrial partner, Johnson Matthey Catalysis and Chiral Technologies.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M017095/1 01/10/2015 30/09/2019
1658860 Studentship BB/M017095/1 01/10/2015 30/09/2019 Michalis Posidias
Description We have results showing that we can increase the conversion and selectivity of alcohol to carbonyls using a number of enzymatic approaches; this is challenging to achieve with traditional chemical methods. The conversions achieved are already competitive with those described in the literature.
Exploitation Route This type of chemical reaction is useful in a number of chemical sectors for the production of pharmaceuticals and other fine chemicals.
Sectors Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL http://vincent.chem.ox.ac.uk/