The interplay of wildlife, livestock and humans in African zoonotic-schistosomiasis transmission dynamics

Lead Research Organisation: Royal Veterinary College
Department Name: Pathology and Pathogen Biology

Abstract

The interplay of wildlife, livestock and humans in African zoonotic-schistosomiasis transmission dynamics

Publications

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Catalano S (2019) sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis. in International journal for parasitology. Parasites and wildlife

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Catalano S (2019) sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis. in International journal for parasitology. Parasites and wildlife

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Catalano S (2020) Multi-host transmission of Schistosoma mansoni in Senegal in Emerging Infectious Diseases

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/N503563/1 01/10/2015 30/09/2019
1659315 Studentship BB/N503563/1 01/10/2015 31/03/2019 Stefano Catalano
 
Title Science Journal for Kids article: cutting edge peer-reviewed science research papers adapted for students. 
Description adaptation of our recent Journal of Infectious Disease article into a grass-roots teen friendly version On average, the site has about 20 to 30,000 visits per month. Science Journal for Kids article: cutting edge peer-reviewed science research papers adapted for students. https://www.sciencejournalforkids.org/search-articles/what-role-do-rodents-have-in-human-snail-fever https://www.sciencejournalforkids.org/uploads/5/4/2/8/54289603/rodents-article.pdf 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2019 
Impact High profiles and commentary across social media e.g. twitter Feb 2019 • 28 days TWEET HIGHLIGHTS Top Tweet earned 3,778 impressions And a bit more to show on our new teen/grass-roots version of our wildlife reservoirs for schistsosomiais paper #ZELS pic.twitter.com/GgZN8ZdM8b Translation into French input into local schools within Senegal and Niger for grass roots public understanding 
URL https://www.sciencejournalforkids.org/search-articles/what-role-do-rodents-have-in-human-snail-fever
 
Description We have investigated the complex multi-host disease dynamics of Schistosoma spp., including the emergence of zoonotic parasitic hybrids, which remain largely unexplored in West Africa. We elucidated the role of wild small mammals as reservoir hosts of Schistosoma mansoni and accidental hosts of Schistosoma hybrids in endemic areas of Senegal. Our findings indicate that rodents may be an important local reservoir for zoonotic schistosomiasis in endemic areas of West Africa, amplifying transmission to humans and jeopardising public health campaigns for disease control.
Exploitation Route This project has the potential to inform and guide future national and international control activities and assist local communities in the fight against schistosomiasis. Our research aims to contribute to the major push to eliminate schistosomiasis as a public health problem as recently prioritized by the WHO NTD roadmap. In order to reach this goal, it is essential to identify wildlife reservoirs of schistosomiasis and the mechanisms of hybridization/introgression shaping Schistosoma spp. evolution in these hosts. Our results are of substantial applied importance by helping public health officials, policy makers, and veterinary agencies to identify the preventive measures to reduce transmission risk and to design guidelines for disease management. Better tailored policies should also lead to improved management with concurrent increase in animal health, which will in turn assist in lifting rural human populations out of poverty in both the short and the sustained longer term.
Sectors Agriculture, Food and Drink,Communities and Social Services/Policy,Education,Environment,Healthcare,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology

URL https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiy029/4819098
 
Description Our paper (Catalano, S., Sene, M., Diouf, N.D., Fall, C.B., Borlase, A., Leger, E, Ba, K., & Webster, J.P. (2018). Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa. The Journal of Infectious Diseases 218 (3) 429-433. https https://doi.org/10.1093/infdis/jiy029) was adapted into English and French Teen Science journal versions with highest recorded 2019 downloads and media coverage (https://www.sciencejournalforkids.org/search-articles/what-role-do-rodents-have-in-human-snail-fever). Furthermore, our research has been highlighted by the London Centre for Neglected Tropical Disease Research in a blog that reached non-governmental institutions and stakeholders (https://www.londonntd.org/news/schistosomiasiss-evolutionary-response-to-a-changing-world-can-we-keep-up).
First Year Of Impact 2019
Sector Communities and Social Services/Policy,Education
Impact Types Cultural,Policy & public services

 
Description One Health Fellowship for the 5th International One Health Congress (Saskatoon, Canada)
Amount £850 (GBP)
Organisation University of Saskatchewan 
Sector Academic/University
Country Canada
Start 06/2018 
End 07/2018
 
Description Data analysis 
Organisation The Wellcome Trust Sanger Institute
Department Pathogen Genomics
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Access to specimens collected during fieldwork in West Africa.
Collaborator Contribution Access to genomic data and advice on best-fit analyses for multi-host zoonotic Schistosoma parasites.
Impact The disciplines involved are mainly bioinformatics, public health and wildlife disease. Data analysis is ongoing and outputs are expected in the second half of 2019.
Start Year 2017
 
Description fieldwork IRD 
Organisation Institute of Development Research (IRD)
Department Research Institute for Development Senegal
Country Senegal 
Sector Academic/University 
PI Contribution Planning and management of fieldwork in Senegal focusing on small mammal trapping in endemic region for schistosomiasis.
Collaborator Contribution Provision of materials and guidance.
Impact Publication of scientific papers (listed in the "Publications" section.
Start Year 2016
 
Description laboratory analysis NHM 
Organisation Natural History Museum
Country United Kingdom 
Sector Public 
PI Contribution Collection of biological specimens for the current and further studies.
Collaborator Contribution Expertise on laboratory analysis of Schistosoma parasites and other trematodes.
Impact Training of personnel in both England and Senegal where fieldwork is carried.
Start Year 2016
 
Description Invited Expert Advisor presentation/working group leader. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Invited Expert Advisor /working group leader. World Health Organisation (WHO) headquarters, Geneva, Switzerland

Monitoring and Evaultion of drug efficacies in mass drug administration programmes.
Year(s) Of Engagement Activity 2018,2019,2020
 
Description Invited Guest Keynote Lecture The Royal Society, London, UK, 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Webster, J.P. (2017). A One Health approach to controlling zoonotic schistosomiasis in a changing world. (Roy's Symposium). Invited Guest Keynote Lecture The Royal Society, London, UK,
Year(s) Of Engagement Activity 2017
 
Description Invited Guest Keynote Lecture. British Society for Parasitology Autumn Symposium, Linnaen Society, London, 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Webster, J.P. (2017). Zoonotic schistosomiasis in a changing world. Invited Guest Keynote Lecture. British Society for Parasitology Autumn Symposium, Linnaen Society, London, UK (28th Sept.).
Year(s) Of Engagement Activity 2017
 
Description Invited Guest Lecture. British Society for Parasitology Spring Symposium, 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited Key Note Lecture to general scientific audience.Webster, J.P. (2018). Epidemiology an Evolution of Zoonotic schistosomiasis in Afruca: challenges for reaching the WHO elimination targets. Invited Guest Lecture. British Society for Parasitology Spring Symposium, Aberystwyth University, UK
Year(s) Of Engagement Activity 2018
 
Description WHO Schistosomiasis Guideline Development Group (GDG) - Drafting revised WHO Guidelines for Schistososomiasis 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Development of Revised Guidelines for implementation of control and elimination of schistosomiasis and verification of interruption of transmission - Expert Advisor

General scope and objectives

Currently, there is no guidance available to evaluate the interruption of schistosomiasis transmission. The existing implementation guidelines are based mainly on expert opinion and need to be revised according to the available scientific evidence.

The goal of this GDG meeting will be to provide evidence-based recommendations to countries in their efforts to control morbidity from schistosomiasis and eventually interrupt transmission. They will help countries to implement national schistosomiasis control programmes and to verify whether transmission of the disease has been interrupted in the country.
Year(s) Of Engagement Activity 2019,2020
URL https://www.who.int/schistosomiasis/news/public-consultation-experts-guideline-development-group/en/...
 
Description WHO Technical Working Group: Protocols to Verify Interruption of Transmission of Schistosomiasis. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact WHO Technical Working Group: Protocols to Verify Interruption of Transmission of Schistosomiasis.

Expert Advisor for drawing up WHO protocols and guildelines.
Year(s) Of Engagement Activity 2019,2020