How do our gut bacteria communicate with the brain? (SSA)

Lead Research Organisation: University of East Anglia
Department Name: Graduate Office

Abstract

Recent studies have suggested that gut bacteria can impact neurological outcomes, altering behaviour and potentially affecting the onset and/or severity of nervous system disorders such as autism or Parkinson's diseases. However the precise mechanisms of how the intestinal microbes impact neurological function and behaviour remain largely unknown.

This PhD project will use a trans-disciplinary approach including gnotobiotic rodent models to decipher the role of mucin-degrading gut bacteria species on brain function and neurogenesis. This project will provide mechanistic insights into gut-microbiome-brain connections and help rationally design microbiota-based strategies for brain disorders.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
1772155 Studentship BB/M011216/1 01/10/2016 30/09/2020 Erika Coletto
 
Description Bursary winner for conference
Amount £257 (GBP)
Organisation Wellcome Genome Campus 
Start 12/2018 
End 12/2018
 
Description Conference- Poster presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The conference "Exploring Human Host-Microbiome Interactions in Health and Disease" was held at the Wellcome Genome Campus Conference Centre Hinxton, Cambridge and had the purpose to bring altogether the last research outcomes and discoveries in the gut microbiota field.
In particular, the meeting highlighted the critical role of gut bacteria in health and disease, exploring its impact in the gut-brain axis and colon-rectal cancer research as well as showing the new methodologies and tools to study the gut microbiota composition (16S, metatranscriptomics, metagenomics, etc).
Attending at this conference gave me the possibilities to know more about the research ongoing in the gut-brain axis and to exchange scientific idea and opinion with some of the experts of the field, giving my contribute to the information we have to date.
Year(s) Of Engagement Activity 2018
 
Description Knowledge Exchange - University of Parma Foopd Science and Technology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The activity had the purpose to exchange knowledge with the PhD students of the University of Parma. We had one day of projects presentation for both the group and then we have been show around the University and the facilities over there.
It was very interesting and it opened door for future possible collaborations.
Year(s) Of Engagement Activity 2018
 
Description Oral presentation- Microbial Interaction 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The Microbes in Norwich (MICRON) group invites all Early Career Researchers to participate in a one day workshop entitled "Microbial Interactions", which is designed to show-case the research activities of PhD students and postdocs across the Norwich Research Park (NRP) working in this broad area of microbiological research.
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/early-career-researcher-symposium-on-microbial-interactions-tickets-4...
 
Description Women of the future- School Visit (Norfolk area) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 200 girls (14-15 years old) from schools across the Norfolk county came to visit for one day the research Institutions within the Norwich Research Park to meet a great diverse group of women working in different fields. A key aim of the event was to demonstrate the huge range of opportunities available in science for women and that they are not s just for boys.
Moreover, it was important promoting equality and diversity for all the students, in turn to realise the immense value of inspiring the next generation of female STEMM professionals.
Year(s) Of Engagement Activity 2018
 
Description YOUTH STEMM AWARD- school visit (Norfolk area) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact The Youth STEMM Award (YSA),aimed to inspire and encourage secondary students (years 9-13) to become involved in STEMM subjects. In the day of the event the pupils were engaging the postgraduate students to develop knowledge and skills in key science areas.
Year(s) Of Engagement Activity 2017
URL https://ysawards.co.uk/
 
Description general public 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Soapbox science is an outreach platform for promoting women in science and the activity they do. It represents a nice way to deliver scientific knowledge to the public area and let the common people know what research is about, in a easy and accessible way for non-science people.
Using pictures, props and simple talks it was surprising see the interest of the public and the afterward awareness of related topics.
Year(s) Of Engagement Activity 2018
URL http://soapboxscience.org/